Effects of timing, location and definition of reinfarction on mortality in patients with totally occluded infarct related arteries late after myocardial infarction
Identifieur interne : 001620 ( Pmc/Checkpoint ); précédent : 001619; suivant : 001621Effects of timing, location and definition of reinfarction on mortality in patients with totally occluded infarct related arteries late after myocardial infarction
Auteurs : Christopher Adlbrecht ; Kurt Huber ; Harmony R. Reynolds ; Antonio C. Carvalho ; Vladimír Džavík [Canada] ; Philippe Gabriel Steg ; Li Liu ; Paolo Marino ; Camille A. Pearte ; James M. Rankin ; Harvey D. White ; Gervasio A. Lamas ; Judith S. HochmanSource :
- International journal of cardiology [ 0167-5273 ] ; 2014.
Abstract
The Occluded Artery Trial (OAT) randomized stable patients (n=2,201) >24 hours (calendar days 3–28) after myocardial infarction (MI) with totally occluded infarct-related arteries (IRA), to percutaneous coronary intervention (PCI) with optimal medical therapy, or optimal medical therapy alone (MED). PCI had no impact on the composite of death, reinfarction, or class IV heart failure over extended follow-up of up to 9 years. We evaluated the impact of early and late reinfarction and definition of MI on subsequent mortality.
Reinfarction was adjudicated according to an adaptation of the 2007 universal definition of MI and the OAT definition (≥2 of the following - symptoms, EKG and biomarkers). Cox regression models were used to analyze the effect of post-randomization reinfarction and baseline variables on time to death.
After adjustment for baseline characteristics the 169 (PCI: n=95; MED: n=74) patients who developed reinfarction by the universal definition had a 4.15-fold (95% CI 3.03–5.69, p<0.001) increased risk of death compared to patients without reinfarction. This risk was similar for both treatment groups (interaction p=0.26) and when MI was defined by the stricter OAT criteria. Reinfarctions occurring within 6 months of randomization had similar impact on mortality as reinfarctions occurring later, and the impact of reinfarction due to the same IRA and a different epicardial vessel was similar.
For stable post-MI patients with totally occluded infarct arteries, reinfarction significantly independently increased the risk of death regardless of the initial management strategy (PCI vs. MED), reinfarction definition, location and early or late occurrence.
Url:
DOI: 10.1016/j.ijcard.2014.03.149
PubMed: 24726166
PubMed Central: 4067126
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:4067126Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of timing, location and definition of reinfarction on mortality in patients with totally occluded infarct related arteries late after myocardial infarction</title><author><name sortKey="Adlbrecht, Christopher" sort="Adlbrecht, Christopher" uniqKey="Adlbrecht C" first="Christopher" last="Adlbrecht">Christopher Adlbrecht</name><affiliation><nlm:aff id="A1">Department of Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</nlm:aff><wicri:noCountry code="subfield">Austria - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</wicri:noCountry></affiliation></author><author><name sortKey="Huber, Kurt" sort="Huber, Kurt" uniqKey="Huber K" first="Kurt" last="Huber">Kurt Huber</name><affiliation><nlm:aff id="A2">3<sup>rd</sup> Department of Internal Medicine, Cardiology and Emergency Medicine, Wilhelminenhospital, Vienna, Austria - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</nlm:aff><wicri:noCountry code="subfield">Austria - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</wicri:noCountry></affiliation></author><author><name sortKey="Reynolds, Harmony R" sort="Reynolds, Harmony R" uniqKey="Reynolds H" first="Harmony R." last="Reynolds">Harmony R. Reynolds</name><affiliation><nlm:aff id="A3">Cardiovascular Clinical Research Center, New York University School of Medicine, New York, United States of America - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</nlm:aff><wicri:noCountry code="subfield">United States of America - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</wicri:noCountry></affiliation></author><author><name sortKey="Carvalho, Antonio C" sort="Carvalho, Antonio C" uniqKey="Carvalho A" first="Antonio C." last="Carvalho">Antonio C. Carvalho</name><affiliation><nlm:aff id="A4">Hospital Sao Paulo, Moema, Sao Paulo, Brazil - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</nlm:aff><wicri:noCountry code="subfield">Brazil - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</wicri:noCountry></affiliation></author><author><name sortKey="Dzavik, Vladimir" sort="Dzavik, Vladimir" uniqKey="Dzavik V" first="Vladimír" last="Džavík">Vladimír Džavík</name><affiliation wicri:level="1"><nlm:aff id="A5">Peter Munk Cardiac Centre, University Health Network, Toronto, Canada - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</nlm:aff><country>Canada</country><wicri:regionArea>Peter Munk Cardiac Centre, University Health Network, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Steg, Philippe Gabriel" sort="Steg, Philippe Gabriel" uniqKey="Steg P" first="Philippe Gabriel" last="Steg">Philippe Gabriel Steg</name><affiliation><nlm:aff id="A6">INSERM U-698, Paris France; Université Paris-Diderot, Paris, France; Assistance Publique-Hôpitaux de Paris, Centre Hospitalier Bichat-Claude Bernard, Paris, France - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</nlm:aff><wicri:noCountry code="subfield">France - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</wicri:noCountry></affiliation></author><author><name sortKey="Liu, Li" sort="Liu, Li" uniqKey="Liu L" first="Li" last="Liu">Li Liu</name><affiliation><nlm:aff id="A7">Clinical Trial and Surveys Corp. Baltimore, United States of America - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</nlm:aff><wicri:noCountry code="subfield">United States of America - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</wicri:noCountry></affiliation></author><author><name sortKey="Marino, Paolo" sort="Marino, Paolo" uniqKey="Marino P" first="Paolo" last="Marino">Paolo Marino</name><affiliation><nlm:aff id="A8">University of Verona/Instituti Ospedalieri, Verona, Italy - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</nlm:aff><wicri:noCountry code="subfield">Italy - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</wicri:noCountry></affiliation></author><author><name sortKey="Pearte, Camille A" sort="Pearte, Camille A" uniqKey="Pearte C" first="Camille A." last="Pearte">Camille A. Pearte</name><affiliation><nlm:aff id="A9">Cardiovascular Clinical Research Center, New York University School of Medicine, New York, United States of America - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</nlm:aff><wicri:noCountry code="subfield">United States of America - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</wicri:noCountry></affiliation></author><author><name sortKey="Rankin, James M" sort="Rankin, James M" uniqKey="Rankin J" first="James M." last="Rankin">James M. Rankin</name><affiliation><nlm:aff id="A10">Perth Cardiovascular Institute, Perth, Australia - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</nlm:aff><wicri:noCountry code="subfield">Australia - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</wicri:noCountry></affiliation></author><author><name sortKey="White, Harvey D" sort="White, Harvey D" uniqKey="White H" first="Harvey D." last="White">Harvey D. White</name><affiliation><nlm:aff id="A11">Green Lane Cardiovascular Service. Auckland, New Zealand - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</nlm:aff><wicri:noCountry code="subfield">New Zealand - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</wicri:noCountry></affiliation></author><author><name sortKey="Lamas, Gervasio A" sort="Lamas, Gervasio A" uniqKey="Lamas G" first="Gervasio A." last="Lamas">Gervasio A. Lamas</name><affiliation><nlm:aff id="A11">Green Lane Cardiovascular Service. Auckland, New Zealand - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</nlm:aff><wicri:noCountry code="subfield">New Zealand - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</wicri:noCountry></affiliation></author><author><name sortKey="Hochman, Judith S" sort="Hochman, Judith S" uniqKey="Hochman J" first="Judith S." last="Hochman">Judith S. Hochman</name><affiliation><nlm:aff id="A12">Cardiovascular Clinical Research Center, New York University School of Medicine, New York, United States of America - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</nlm:aff><wicri:noCountry code="subfield">United States of America - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24726166</idno><idno type="pmc">4067126</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067126</idno><idno type="RBID">PMC:4067126</idno><idno type="doi">10.1016/j.ijcard.2014.03.149</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002013</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002013</idno><idno type="wicri:Area/Pmc/Curation">001E67</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001E67</idno><idno type="wicri:Area/Pmc/Checkpoint">001620</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001620</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effects of timing, location and definition of reinfarction on mortality in patients with totally occluded infarct related arteries late after myocardial infarction</title><author><name sortKey="Adlbrecht, Christopher" sort="Adlbrecht, Christopher" uniqKey="Adlbrecht C" first="Christopher" last="Adlbrecht">Christopher Adlbrecht</name><affiliation><nlm:aff id="A1">Department of Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</nlm:aff><wicri:noCountry code="subfield">Austria - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</wicri:noCountry></affiliation></author><author><name sortKey="Huber, Kurt" sort="Huber, Kurt" uniqKey="Huber K" first="Kurt" last="Huber">Kurt Huber</name><affiliation><nlm:aff id="A2">3<sup>rd</sup> Department of Internal Medicine, Cardiology and Emergency Medicine, Wilhelminenhospital, Vienna, Austria - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</nlm:aff><wicri:noCountry code="subfield">Austria - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</wicri:noCountry></affiliation></author><author><name sortKey="Reynolds, Harmony R" sort="Reynolds, Harmony R" uniqKey="Reynolds H" first="Harmony R." last="Reynolds">Harmony R. Reynolds</name><affiliation><nlm:aff id="A3">Cardiovascular Clinical Research Center, New York University School of Medicine, New York, United States of America - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</nlm:aff><wicri:noCountry code="subfield">United States of America - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</wicri:noCountry></affiliation></author><author><name sortKey="Carvalho, Antonio C" sort="Carvalho, Antonio C" uniqKey="Carvalho A" first="Antonio C." last="Carvalho">Antonio C. Carvalho</name><affiliation><nlm:aff id="A4">Hospital Sao Paulo, Moema, Sao Paulo, Brazil - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</nlm:aff><wicri:noCountry code="subfield">Brazil - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</wicri:noCountry></affiliation></author><author><name sortKey="Dzavik, Vladimir" sort="Dzavik, Vladimir" uniqKey="Dzavik V" first="Vladimír" last="Džavík">Vladimír Džavík</name><affiliation wicri:level="1"><nlm:aff id="A5">Peter Munk Cardiac Centre, University Health Network, Toronto, Canada - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</nlm:aff><country>Canada</country><wicri:regionArea>Peter Munk Cardiac Centre, University Health Network, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Steg, Philippe Gabriel" sort="Steg, Philippe Gabriel" uniqKey="Steg P" first="Philippe Gabriel" last="Steg">Philippe Gabriel Steg</name><affiliation><nlm:aff id="A6">INSERM U-698, Paris France; Université Paris-Diderot, Paris, France; Assistance Publique-Hôpitaux de Paris, Centre Hospitalier Bichat-Claude Bernard, Paris, France - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</nlm:aff><wicri:noCountry code="subfield">France - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</wicri:noCountry></affiliation></author><author><name sortKey="Liu, Li" sort="Liu, Li" uniqKey="Liu L" first="Li" last="Liu">Li Liu</name><affiliation><nlm:aff id="A7">Clinical Trial and Surveys Corp. Baltimore, United States of America - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</nlm:aff><wicri:noCountry code="subfield">United States of America - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</wicri:noCountry></affiliation></author><author><name sortKey="Marino, Paolo" sort="Marino, Paolo" uniqKey="Marino P" first="Paolo" last="Marino">Paolo Marino</name><affiliation><nlm:aff id="A8">University of Verona/Instituti Ospedalieri, Verona, Italy - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</nlm:aff><wicri:noCountry code="subfield">Italy - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</wicri:noCountry></affiliation></author><author><name sortKey="Pearte, Camille A" sort="Pearte, Camille A" uniqKey="Pearte C" first="Camille A." last="Pearte">Camille A. Pearte</name><affiliation><nlm:aff id="A9">Cardiovascular Clinical Research Center, New York University School of Medicine, New York, United States of America - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</nlm:aff><wicri:noCountry code="subfield">United States of America - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</wicri:noCountry></affiliation></author><author><name sortKey="Rankin, James M" sort="Rankin, James M" uniqKey="Rankin J" first="James M." last="Rankin">James M. Rankin</name><affiliation><nlm:aff id="A10">Perth Cardiovascular Institute, Perth, Australia - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</nlm:aff><wicri:noCountry code="subfield">Australia - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</wicri:noCountry></affiliation></author><author><name sortKey="White, Harvey D" sort="White, Harvey D" uniqKey="White H" first="Harvey D." last="White">Harvey D. White</name><affiliation><nlm:aff id="A11">Green Lane Cardiovascular Service. Auckland, New Zealand - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</nlm:aff><wicri:noCountry code="subfield">New Zealand - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</wicri:noCountry></affiliation></author><author><name sortKey="Lamas, Gervasio A" sort="Lamas, Gervasio A" uniqKey="Lamas G" first="Gervasio A." last="Lamas">Gervasio A. Lamas</name><affiliation><nlm:aff id="A11">Green Lane Cardiovascular Service. Auckland, New Zealand - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</nlm:aff><wicri:noCountry code="subfield">New Zealand - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</wicri:noCountry></affiliation></author><author><name sortKey="Hochman, Judith S" sort="Hochman, Judith S" uniqKey="Hochman J" first="Judith S." last="Hochman">Judith S. Hochman</name><affiliation><nlm:aff id="A12">Cardiovascular Clinical Research Center, New York University School of Medicine, New York, United States of America - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</nlm:aff><wicri:noCountry code="subfield">United States of America - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</wicri:noCountry></affiliation></author></analytic><series><title level="j">International journal of cardiology</title><idno type="ISSN">0167-5273</idno><idno type="eISSN">1874-1754</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Structured Abstract</title><sec id="S1"><title>Background</title><p id="P3">The Occluded Artery Trial (OAT) randomized stable patients (n=2,201) >24 hours (calendar days 3–28) after myocardial infarction (MI) with totally occluded infarct-related arteries (IRA), to percutaneous coronary intervention (PCI) with optimal medical therapy, or optimal medical therapy alone (MED). PCI had no impact on the composite of death, reinfarction, or class IV heart failure over extended follow-up of up to 9 years. We evaluated the impact of early and late reinfarction and definition of MI on subsequent mortality.</p></sec><sec id="S2"><title>Methods and Results</title><p id="P4">Reinfarction was adjudicated according to an adaptation of the 2007 universal definition of MI and the OAT definition (≥2 of the following - symptoms, EKG and biomarkers). Cox regression models were used to analyze the effect of post-randomization reinfarction and baseline variables on time to death.</p><p id="P5">After adjustment for baseline characteristics the 169 (PCI: n=95; MED: n=74) patients who developed reinfarction by the universal definition had a 4.15-fold (95% CI 3.03–5.69, p<0.001) increased risk of death compared to patients without reinfarction. This risk was similar for both treatment groups (interaction p=0.26) and when MI was defined by the stricter OAT criteria. Reinfarctions occurring within 6 months of randomization had similar impact on mortality as reinfarctions occurring later, and the impact of reinfarction due to the same IRA and a different epicardial vessel was similar.</p></sec><sec id="S3"><title>Conclusions</title><p id="P6">For stable post-MI patients with totally occluded infarct arteries, reinfarction significantly independently increased the risk of death regardless of the initial management strategy (PCI vs. MED), reinfarction definition, location and early or late occurrence.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8200291</journal-id><journal-id journal-id-type="pubmed-jr-id">4286</journal-id><journal-id journal-id-type="nlm-ta">Int J Cardiol</journal-id><journal-id journal-id-type="iso-abbrev">Int. J. Cardiol.</journal-id><journal-title-group><journal-title>International journal of cardiology</journal-title></journal-title-group><issn pub-type="ppub">0167-5273</issn><issn pub-type="epub">1874-1754</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24726166</article-id><article-id pub-id-type="pmc">4067126</article-id><article-id pub-id-type="doi">10.1016/j.ijcard.2014.03.149</article-id><article-id pub-id-type="manuscript">NIHMS585171</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Effects of timing, location and definition of reinfarction on mortality in patients with totally occluded infarct related arteries late after myocardial infarction</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Adlbrecht</surname><given-names>Christopher</given-names></name><degrees>MD, MBA</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Huber</surname><given-names>Kurt</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Reynolds</surname><given-names>Harmony R.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Carvalho</surname><given-names>Antonio C.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Džavík</surname><given-names>Vladimír</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Steg</surname><given-names>Philippe Gabriel</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Li</given-names></name><degrees>MS</degrees><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Marino</surname><given-names>Paolo</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Pearte</surname><given-names>Camille A.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Rankin</surname><given-names>James M.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>White</surname><given-names>Harvey D.</given-names></name><degrees>DSC</degrees><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Lamas</surname><given-names>Gervasio A.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Hochman</surname><given-names>Judith S.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A12">12</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</aff><aff id="A2"><label>2</label>3<sup>rd</sup> Department of Internal Medicine, Cardiology and Emergency Medicine, Wilhelminenhospital, Vienna, Austria - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</aff><aff id="A3"><label>3</label>Cardiovascular Clinical Research Center, New York University School of Medicine, New York, United States of America - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</aff><aff id="A4"><label>4</label>Hospital Sao Paulo, Moema, Sao Paulo, Brazil - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</aff><aff id="A5"><label>5</label>Peter Munk Cardiac Centre, University Health Network, Toronto, Canada - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</aff><aff id="A6"><label>6</label>INSERM U-698, Paris France; Université Paris-Diderot, Paris, France; Assistance Publique-Hôpitaux de Paris, Centre Hospitalier Bichat-Claude Bernard, Paris, France - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</aff><aff id="A7"><label>7</label>Clinical Trial and Surveys Corp. Baltimore, United States of America - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</aff><aff id="A8"><label>8</label>University of Verona/Instituti Ospedalieri, Verona, Italy - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</aff><aff id="A9"><label>9</label>Cardiovascular Clinical Research Center, New York University School of Medicine, New York, United States of America - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</aff><aff id="A10"><label>10</label>Perth Cardiovascular Institute, Perth, Australia - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</aff><aff id="A11"><label>11</label>Green Lane Cardiovascular Service. Auckland, New Zealand - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</aff><aff id="A12"><label>12</label>Cardiovascular Clinical Research Center, New York University School of Medicine, New York, United States of America - “This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.”</aff><author-notes><corresp id="FN1">Address for Correspondence: Judith S. Hochman, MD, NYU Cardiovascular Clinical Research Center, Leon Charney Division of Cardiology, New York University School of Medicine, 530 First Avenue, SKI-9R; New York, NY10016, Tel: 212-263-6927, Fax: 212-263-7129, <email>Judith.Hochman@nyumc.org</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>15</day><month>5</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>28</day><month>3</month><year>2014</year></pub-date><pub-date pub-type="ppub"><day>1</day><month>6</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>6</month><year>2015</year></pub-date><volume>174</volume><issue>1</issue><fpage>90</fpage><lpage>95</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.ijcard.2014.03.149</pmc-comment>
<permissions><copyright-statement>© 2014 Elsevier Ireland Ltd. All rights reserved.</copyright-statement><copyright-year>2014</copyright-year></permissions><abstract><title>Structured Abstract</title><sec id="S1"><title>Background</title><p id="P3">The Occluded Artery Trial (OAT) randomized stable patients (n=2,201) >24 hours (calendar days 3–28) after myocardial infarction (MI) with totally occluded infarct-related arteries (IRA), to percutaneous coronary intervention (PCI) with optimal medical therapy, or optimal medical therapy alone (MED). PCI had no impact on the composite of death, reinfarction, or class IV heart failure over extended follow-up of up to 9 years. We evaluated the impact of early and late reinfarction and definition of MI on subsequent mortality.</p></sec><sec id="S2"><title>Methods and Results</title><p id="P4">Reinfarction was adjudicated according to an adaptation of the 2007 universal definition of MI and the OAT definition (≥2 of the following - symptoms, EKG and biomarkers). Cox regression models were used to analyze the effect of post-randomization reinfarction and baseline variables on time to death.</p><p id="P5">After adjustment for baseline characteristics the 169 (PCI: n=95; MED: n=74) patients who developed reinfarction by the universal definition had a 4.15-fold (95% CI 3.03–5.69, p<0.001) increased risk of death compared to patients without reinfarction. This risk was similar for both treatment groups (interaction p=0.26) and when MI was defined by the stricter OAT criteria. Reinfarctions occurring within 6 months of randomization had similar impact on mortality as reinfarctions occurring later, and the impact of reinfarction due to the same IRA and a different epicardial vessel was similar.</p></sec><sec id="S3"><title>Conclusions</title><p id="P6">For stable post-MI patients with totally occluded infarct arteries, reinfarction significantly independently increased the risk of death regardless of the initial management strategy (PCI vs. MED), reinfarction definition, location and early or late occurrence.</p></sec></abstract><kwd-group><kwd>Reinfarction</kwd><kwd>late revascularization</kwd><kwd>myocardial infarction</kwd><kwd>mortality</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Adlbrecht, Christopher" sort="Adlbrecht, Christopher" uniqKey="Adlbrecht C" first="Christopher" last="Adlbrecht">Christopher Adlbrecht</name><name sortKey="Carvalho, Antonio C" sort="Carvalho, Antonio C" uniqKey="Carvalho A" first="Antonio C." last="Carvalho">Antonio C. Carvalho</name><name sortKey="Hochman, Judith S" sort="Hochman, Judith S" uniqKey="Hochman J" first="Judith S." last="Hochman">Judith S. Hochman</name><name sortKey="Huber, Kurt" sort="Huber, Kurt" uniqKey="Huber K" first="Kurt" last="Huber">Kurt Huber</name><name sortKey="Lamas, Gervasio A" sort="Lamas, Gervasio A" uniqKey="Lamas G" first="Gervasio A." last="Lamas">Gervasio A. Lamas</name><name sortKey="Liu, Li" sort="Liu, Li" uniqKey="Liu L" first="Li" last="Liu">Li Liu</name><name sortKey="Marino, Paolo" sort="Marino, Paolo" uniqKey="Marino P" first="Paolo" last="Marino">Paolo Marino</name><name sortKey="Pearte, Camille A" sort="Pearte, Camille A" uniqKey="Pearte C" first="Camille A." last="Pearte">Camille A. Pearte</name><name sortKey="Rankin, James M" sort="Rankin, James M" uniqKey="Rankin J" first="James M." last="Rankin">James M. Rankin</name><name sortKey="Reynolds, Harmony R" sort="Reynolds, Harmony R" uniqKey="Reynolds H" first="Harmony R." last="Reynolds">Harmony R. Reynolds</name><name sortKey="Steg, Philippe Gabriel" sort="Steg, Philippe Gabriel" uniqKey="Steg P" first="Philippe Gabriel" last="Steg">Philippe Gabriel Steg</name><name sortKey="White, Harvey D" sort="White, Harvey D" uniqKey="White H" first="Harvey D." last="White">Harvey D. White</name></noCountry><country name="Canada"><noRegion><name sortKey="Dzavik, Vladimir" sort="Dzavik, Vladimir" uniqKey="Dzavik V" first="Vladimír" last="Džavík">Vladimír Džavík</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001620 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 001620 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Pmc
|étape= Checkpoint
|type= RBID
|clé= PMC:4067126
|texte= Effects of timing, location and definition of reinfarction on mortality in patients with totally occluded infarct related arteries late after myocardial infarction
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:24726166" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |