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Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study

Identifieur interne : 001571 ( Pmc/Checkpoint ); précédent : 001570; suivant : 001572

Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study

Auteurs : Nichola Johnson [Royaume-Uni] ; Frank Dudbridge [Royaume-Uni] ; Nick Orr [Royaume-Uni] ; Lorna Gibson [Royaume-Uni] ; Michael E. Jones [Royaume-Uni] ; Minouk J. Schoemaker [Royaume-Uni] ; Elizabeth J. Folkerd [Royaume-Uni] ; Ben P. Haynes [Royaume-Uni] ; John L. Hopper [Australie] ; Melissa C. Southey [Australie] ; Gillian S. Dite [Australie] ; Carmel Apicella [Australie] ; Marjanka K. Schmidt [Pays-Bas] ; Annegien Broeks [Pays-Bas] ; Laura J. Van Veer [Pays-Bas] ; Femke Atsma [Pays-Bas] ; Kenneth Muir [Royaume-Uni] ; Artitaya Lophatananon [Royaume-Uni] ; Peter A. Fasching [Allemagne, États-Unis] ; Matthias W. Beckmann [Allemagne] ; Arif B. Ekici [Allemagne] ; Stefan P. Renner [Allemagne] ; Elinor Sawyer [Royaume-Uni] ; Ian Tomlinson [Royaume-Uni] ; Michael Kerin [Irlande (pays)] ; Nicola Miller [Irlande (pays)] ; Barbara Burwinkel [Allemagne] ; Frederik Marme [Allemagne] ; Andreas Schneeweiss [Allemagne] ; Christof Sohn [Allemagne] ; Pascal Guénel [France] ; Therese Truong [France] ; Emilie Cordina [France] ; Florence Menegaux [France] ; Stig E. Bojesen [Danemark] ; B Rge G. Nordestgaard [Danemark] ; Henrik Flyger [Danemark] ; Roger Milne [Espagne] ; M Pilar Zamora [Espagne] ; Jose Ignacio Arias Perez [Espagne] ; Javier Benitez [Espagne] ; Leslie Bernstein [États-Unis] ; Hoda Anton-Culver [États-Unis] ; Argyrios Ziogas [États-Unis] ; Christina Clarke Dur [États-Unis] ; Hermann Brenner [Allemagne] ; Heiko Müller [Allemagne] ; Volker Arndt [Allemagne] ; Aida Karina Dieffenbach [Allemagne] ; Alfons Meindl [Allemagne] ; Joerg Heil [Allemagne] ; Claus R. Bartram [Allemagne] ; Rita K. Schmutzler [Allemagne] ; Hiltrud Brauch [Allemagne] ; Christina Justenhoven [Allemagne] ; Yon-Dschun Ko [Allemagne]

Source :

RBID : PMC:4522594

Abstract

Introduction

We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22.1), was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age ≤50 years.

Methods

We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Association Consortium. Genotyping of rs10235235 was conducted using a custom Illumina Infinium array. Stratified analyses were conducted to determine whether this association was modified by age at diagnosis, ethnicity, age at menarche or tumor characteristics.

Results

We confirmed the association of rs10235235 with breast cancer risk for women of European ancestry but found no evidence that this association differed with age at diagnosis. Heterozygote and homozygote odds ratios (ORs) were OR = 0.98 (95% CI 0.94, 1.01; P = 0.2) and OR = 0.80 (95% CI 0.69, 0.93; P = 0.004), respectively (Ptrend = 0.02). There was no evidence of effect modification by tumor characteristics. rs10235235 was, however, associated with age at menarche in controls (Ptrend = 0.005) but not cases (Ptrend = 0.97). Consequently the association between rs10235235 and breast cancer risk differed according to age at menarche (Phet = 0.02); the rare allele of rs10235235 was associated with a reduction in breast cancer risk for women who had their menarche age ≥15 years (ORhet = 0.84, 95% CI 0.75, 0.94; ORhom = 0.81, 95% CI 0.51, 1.30; Ptrend = 0.002) but not for those who had their menarche age ≤11 years (ORhet = 1.06, 95% CI 0.95, 1.19, ORhom = 1.07, 95% CI 0.67, 1.72; Ptrend = 0.29).

Conclusions

To our knowledge rs10235235 is the first single nucleotide polymorphism to be associated with both breast cancer risk and age at menarche consistent with the well-documented association between later age at menarche and a reduction in breast cancer risk. These associations are likely mediated via an effect on circulating hormone levels.


Url:
DOI: 10.1186/bcr3662
PubMed: 24887515
PubMed Central: 4522594


Affiliations:

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PMC:4522594

Le document en format XML

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<name sortKey="Kerin, Michael" sort="Kerin, Michael" uniqKey="Kerin M" first="Michael" last="Kerin">Michael Kerin</name>
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<name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name>
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<nlm:aff id="I17">Surgery, Clinical Science Institute, Galway University Hospital and National University of Ireland, University Road, Galway, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Surgery, Clinical Science Institute, Galway University Hospital and National University of Ireland, University Road, Galway</wicri:regionArea>
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</affiliation>
</author>
<author>
<name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name>
<affiliation wicri:level="3">
<nlm:aff id="I18">Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg</wicri:regionArea>
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<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="I19">Unit Molecular Epidemiology C080, German Cancer Research Center, DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Unit Molecular Epidemiology C080, German Cancer Research Center, DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg</wicri:regionArea>
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<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
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</affiliation>
</author>
<author>
<name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name>
<affiliation wicri:level="3">
<nlm:aff id="I18">Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg</wicri:regionArea>
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<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Schneeweiss, Andreas" sort="Schneeweiss, Andreas" uniqKey="Schneeweiss A" first="Andreas" last="Schneeweiss">Andreas Schneeweiss</name>
<affiliation wicri:level="3">
<nlm:aff id="I18">Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg</wicri:regionArea>
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<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
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</affiliation>
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<author>
<name sortKey="Sohn, Christof" sort="Sohn, Christof" uniqKey="Sohn C" first="Christof" last="Sohn">Christof Sohn</name>
<affiliation wicri:level="3">
<nlm:aff id="I18">Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg</wicri:regionArea>
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<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="I20">National Center for Tumor Diseases, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>National Center for Tumor Diseases, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name>
<affiliation wicri:level="1">
<nlm:aff id="I21">Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654 Paris</wicri:regionArea>
<wicri:noRegion>75654 Paris</wicri:noRegion>
<placeName>
<settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="I22">University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654 Paris</wicri:regionArea>
<wicri:noRegion>75654 Paris</wicri:noRegion>
<placeName>
<settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Therese" last="Truong">Therese Truong</name>
<affiliation wicri:level="1">
<nlm:aff id="I21">Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654 Paris</wicri:regionArea>
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<placeName>
<settlement type="city">Paris</settlement>
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</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="I22">University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654 Paris</wicri:regionArea>
<wicri:noRegion>75654 Paris</wicri:noRegion>
<placeName>
<settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Cordina, Emilie" sort="Cordina, Emilie" uniqKey="Cordina E" first="Emilie" last="Cordina">Emilie Cordina</name>
<affiliation wicri:level="1">
<nlm:aff id="I21">Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654 Paris</wicri:regionArea>
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<placeName>
<settlement type="city">Paris</settlement>
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</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="I22">University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654 Paris</wicri:regionArea>
<wicri:noRegion>75654 Paris</wicri:noRegion>
<placeName>
<settlement type="city">Paris</settlement>
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</affiliation>
</author>
<author>
<name sortKey="Menegaux, Florence" sort="Menegaux, Florence" uniqKey="Menegaux F" first="Florence" last="Menegaux">Florence Menegaux</name>
<affiliation wicri:level="1">
<nlm:aff id="I21">Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654 Paris</wicri:regionArea>
<wicri:noRegion>75654 Paris</wicri:noRegion>
<placeName>
<settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="I22">University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654 Paris</wicri:regionArea>
<wicri:noRegion>75654 Paris</wicri:noRegion>
<placeName>
<settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
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</affiliation>
</author>
<author>
<name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E" last="Bojesen">Stig E. Bojesen</name>
<affiliation wicri:level="3">
<nlm:aff id="I23">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen</wicri:regionArea>
<placeName>
<settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="I24">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen</wicri:regionArea>
<placeName>
<settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G" last="Nordestgaard">B Rge G. Nordestgaard</name>
<affiliation wicri:level="3">
<nlm:aff id="I23">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen</wicri:regionArea>
<placeName>
<settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="I24">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen</wicri:regionArea>
<placeName>
<settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name>
<affiliation wicri:level="1">
<nlm:aff id="I25">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, Herlev, 2730 Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, Herlev, 2730 Copenhagen</wicri:regionArea>
<placeName>
<settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Milne, Roger" sort="Milne, Roger" uniqKey="Milne R" first="Roger" last="Milne">Roger Milne</name>
<affiliation wicri:level="1">
<nlm:aff id="I26">Genetic and Molecular Epidemiology Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Calle de Melchor Fernandez Almagro, 3, 28029 Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Genetic and Molecular Epidemiology Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Calle de Melchor Fernandez Almagro, 3, 28029 Madrid</wicri:regionArea>
<placeName>
<settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Zamora, M Pilar" sort="Zamora, M Pilar" uniqKey="Zamora M" first="M Pilar" last="Zamora">M Pilar Zamora</name>
<affiliation wicri:level="1">
<nlm:aff id="I27">Servicio de Oncología Médica, Hospital Universitario La Paz, Paseo de la Castellana, 261, 28046 Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Servicio de Oncología Médica, Hospital Universitario La Paz, Paseo de la Castellana, 261, 28046 Madrid</wicri:regionArea>
<placeName>
<settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Arias Perez, Jose Ignacio" sort="Arias Perez, Jose Ignacio" uniqKey="Arias Perez J" first="Jose Ignacio" last="Arias Perez">Jose Ignacio Arias Perez</name>
<affiliation wicri:level="1">
<nlm:aff id="I28">Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Avda. Dres. Fernández Vega, 107 Oviedo, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Avda. Dres. Fernández Vega, 107 Oviedo</wicri:regionArea>
<wicri:noRegion>107 Oviedo</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name>
<affiliation wicri:level="1">
<nlm:aff id="I29">Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Calle de Melchor Fernandez Almagro, 3, 28029 Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Calle de Melchor Fernandez Almagro, 3, 28029 Madrid</wicri:regionArea>
<placeName>
<settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
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</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="I30">Centro de Investigación en Red de Enfermedades Raras (CIBERER), Calle de Melchor Fernandez Almagro, 3, 28029 Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Centro de Investigación en Red de Enfermedades Raras (CIBERER), Calle de Melchor Fernandez Almagro, 3, 28029 Madrid</wicri:regionArea>
<placeName>
<settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
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</affiliation>
</author>
<author>
<name sortKey="Bernstein, Leslie" sort="Bernstein, Leslie" uniqKey="Bernstein L" first="Leslie" last="Bernstein">Leslie Bernstein</name>
<affiliation wicri:level="2">
<nlm:aff id="I31">Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA</wicri:regionArea>
<placeName>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name>
<affiliation wicri:level="1">
<nlm:aff id="I32">Department of Epidemiology, School of Medicine, 224 Irvine Hall, University of California Irvine, Irvine, California 92697-7550, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, School of Medicine, 224 Irvine Hall, University of California Irvine, Irvine, California 92697-7550</wicri:regionArea>
<wicri:noRegion>California 92697-7550</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Ziogas, Argyrios" sort="Ziogas, Argyrios" uniqKey="Ziogas A" first="Argyrios" last="Ziogas">Argyrios Ziogas</name>
<affiliation wicri:level="1">
<nlm:aff id="I32">Department of Epidemiology, School of Medicine, 224 Irvine Hall, University of California Irvine, Irvine, California 92697-7550, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, School of Medicine, 224 Irvine Hall, University of California Irvine, Irvine, California 92697-7550</wicri:regionArea>
<wicri:noRegion>California 92697-7550</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Clarke Dur, Christina" sort="Clarke Dur, Christina" uniqKey="Clarke Dur C" first="Christina" last="Clarke Dur">Christina Clarke Dur</name>
<affiliation wicri:level="1">
<nlm:aff id="I33">Cancer Prevention Institute of California, 2201 Walnut Avenue, Suite 300, Fremont, California 95438, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cancer Prevention Institute of California, 2201 Walnut Avenue, Suite 300, Fremont, California 95438</wicri:regionArea>
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</affiliation>
</author>
<author>
<name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name>
<affiliation wicri:level="3">
<nlm:aff id="I34">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg</wicri:regionArea>
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<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="I35">German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69121 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69121 Heidelberg</wicri:regionArea>
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<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
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</placeName>
</affiliation>
</author>
<author>
<name sortKey="Muller, Heiko" sort="Muller, Heiko" uniqKey="Muller H" first="Heiko" last="Müller">Heiko Müller</name>
<affiliation wicri:level="3">
<nlm:aff id="I34">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg</wicri:regionArea>
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<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
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</placeName>
</affiliation>
</author>
<author>
<name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name>
<affiliation wicri:level="3">
<nlm:aff id="I34">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg</wicri:regionArea>
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<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
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</placeName>
</affiliation>
</author>
<author>
<name sortKey="Dieffenbach, Aida Karina" sort="Dieffenbach, Aida Karina" uniqKey="Dieffenbach A" first="Aida Karina" last="Dieffenbach">Aida Karina Dieffenbach</name>
<affiliation wicri:level="3">
<nlm:aff id="I34">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg</wicri:regionArea>
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<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
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</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="I35">German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69121 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69121 Heidelberg</wicri:regionArea>
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<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
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</affiliation>
</author>
<author>
<name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name>
<affiliation wicri:level="3">
<nlm:aff id="I36">Clinic of Gynecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Ismaninger Strasse 22, D-81675 Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Clinic of Gynecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Ismaninger Strasse 22, D-81675 Munich</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
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</affiliation>
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<name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name>
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<nlm:aff id="I1">Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK</nlm:aff>
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<nlm:aff id="I3">Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK</nlm:aff>
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<wicri:regionArea>Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT</wicri:regionArea>
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<nlm:aff id="I1">Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK</nlm:aff>
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<nlm:aff id="I3">Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK</nlm:aff>
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<wicri:regionArea>Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT</wicri:regionArea>
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<nlm:aff id="I4">Division of Genetics and Epidemiology, The Institute of Cancer Research, 15 Cotswold Road, Belmont, Sutton, Surrey SM2 5NG, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
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<nlm:aff id="I4">Division of Genetics and Epidemiology, The Institute of Cancer Research, 15 Cotswold Road, Belmont, Sutton, Surrey SM2 5NG, UK</nlm:aff>
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<nlm:aff id="I5">The Academic Department of Biochemistry, The Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK</nlm:aff>
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<nlm:aff id="I11">University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Postfach 2306, D-91012 Erlangen, Germany</nlm:aff>
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<nlm:aff id="I12">David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, University of California, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA</nlm:aff>
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<nlm:aff id="I14">Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy’s & St. Thomas’ NHS Foundation Trust in partnership with King’s College London, Guy’s Hospital, Great Maze Pond, London SE1 9RT, UK</nlm:aff>
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<wicri:regionArea>Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy’s & St. Thomas’ NHS Foundation Trust in partnership with King’s College London, Guy’s Hospital, Great Maze Pond, London SE1 9RT</wicri:regionArea>
<wicri:noRegion>London SE1 9RT</wicri:noRegion>
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</author>
<author>
<name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name>
<affiliation wicri:level="4">
<nlm:aff id="I15">Welcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Welcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
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<settlement type="city">Oxford</settlement>
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<affiliation wicri:level="4">
<nlm:aff id="I16">Oxford Biomedical Research Centre, University of Oxford, The Churchill Hospital, Old Road, Headington OX3 7LE Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Biomedical Research Centre, University of Oxford, The Churchill Hospital, Old Road, Headington OX3 7LE Oxford</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
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<settlement type="city">Oxford</settlement>
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</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kerin, Michael" sort="Kerin, Michael" uniqKey="Kerin M" first="Michael" last="Kerin">Michael Kerin</name>
<affiliation wicri:level="1">
<nlm:aff id="I17">Surgery, Clinical Science Institute, Galway University Hospital and National University of Ireland, University Road, Galway, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Surgery, Clinical Science Institute, Galway University Hospital and National University of Ireland, University Road, Galway</wicri:regionArea>
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</author>
<author>
<name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name>
<affiliation wicri:level="1">
<nlm:aff id="I17">Surgery, Clinical Science Institute, Galway University Hospital and National University of Ireland, University Road, Galway, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Surgery, Clinical Science Institute, Galway University Hospital and National University of Ireland, University Road, Galway</wicri:regionArea>
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</author>
<author>
<name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name>
<affiliation wicri:level="3">
<nlm:aff id="I18">Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg</wicri:regionArea>
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<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="I19">Unit Molecular Epidemiology C080, German Cancer Research Center, DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Unit Molecular Epidemiology C080, German Cancer Research Center, DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg</wicri:regionArea>
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<name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name>
<affiliation wicri:level="3">
<nlm:aff id="I18">Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg</wicri:regionArea>
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<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
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</affiliation>
</author>
<author>
<name sortKey="Schneeweiss, Andreas" sort="Schneeweiss, Andreas" uniqKey="Schneeweiss A" first="Andreas" last="Schneeweiss">Andreas Schneeweiss</name>
<affiliation wicri:level="3">
<nlm:aff id="I18">Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg</wicri:regionArea>
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<region type="land" nuts="1">Bade-Wurtemberg</region>
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<name sortKey="Sohn, Christof" sort="Sohn, Christof" uniqKey="Sohn C" first="Christof" last="Sohn">Christof Sohn</name>
<affiliation wicri:level="3">
<nlm:aff id="I18">Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg</wicri:regionArea>
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<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
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</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="I20">National Center for Tumor Diseases, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>National Center for Tumor Diseases, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg</wicri:regionArea>
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<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name>
<affiliation wicri:level="1">
<nlm:aff id="I21">Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654 Paris</wicri:regionArea>
<wicri:noRegion>75654 Paris</wicri:noRegion>
<placeName>
<settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="I22">University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654 Paris</wicri:regionArea>
<wicri:noRegion>75654 Paris</wicri:noRegion>
<placeName>
<settlement type="city">Paris</settlement>
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</placeName>
</affiliation>
</author>
<author>
<name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Therese" last="Truong">Therese Truong</name>
<affiliation wicri:level="1">
<nlm:aff id="I21">Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654 Paris</wicri:regionArea>
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<settlement type="city">Paris</settlement>
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</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="I22">University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654 Paris</wicri:regionArea>
<wicri:noRegion>75654 Paris</wicri:noRegion>
<placeName>
<settlement type="city">Paris</settlement>
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</affiliation>
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<author>
<name sortKey="Cordina, Emilie" sort="Cordina, Emilie" uniqKey="Cordina E" first="Emilie" last="Cordina">Emilie Cordina</name>
<affiliation wicri:level="1">
<nlm:aff id="I21">Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654 Paris</wicri:regionArea>
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<settlement type="city">Paris</settlement>
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<affiliation wicri:level="1">
<nlm:aff id="I22">University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654 Paris</wicri:regionArea>
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<placeName>
<settlement type="city">Paris</settlement>
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<author>
<name sortKey="Menegaux, Florence" sort="Menegaux, Florence" uniqKey="Menegaux F" first="Florence" last="Menegaux">Florence Menegaux</name>
<affiliation wicri:level="1">
<nlm:aff id="I21">Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654 Paris</wicri:regionArea>
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<settlement type="city">Paris</settlement>
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<affiliation wicri:level="1">
<nlm:aff id="I22">University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654 Paris</wicri:regionArea>
<wicri:noRegion>75654 Paris</wicri:noRegion>
<placeName>
<settlement type="city">Paris</settlement>
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</affiliation>
</author>
<author>
<name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E" last="Bojesen">Stig E. Bojesen</name>
<affiliation wicri:level="3">
<nlm:aff id="I23">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen</wicri:regionArea>
<placeName>
<settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="I24">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen</wicri:regionArea>
<placeName>
<settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G" last="Nordestgaard">B Rge G. Nordestgaard</name>
<affiliation wicri:level="3">
<nlm:aff id="I23">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen</wicri:regionArea>
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<settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
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</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="I24">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen</wicri:regionArea>
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<settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
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</affiliation>
</author>
<author>
<name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name>
<affiliation wicri:level="1">
<nlm:aff id="I25">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, Herlev, 2730 Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, Herlev, 2730 Copenhagen</wicri:regionArea>
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<settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
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</affiliation>
</author>
<author>
<name sortKey="Milne, Roger" sort="Milne, Roger" uniqKey="Milne R" first="Roger" last="Milne">Roger Milne</name>
<affiliation wicri:level="1">
<nlm:aff id="I26">Genetic and Molecular Epidemiology Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Calle de Melchor Fernandez Almagro, 3, 28029 Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Genetic and Molecular Epidemiology Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Calle de Melchor Fernandez Almagro, 3, 28029 Madrid</wicri:regionArea>
<placeName>
<settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
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</affiliation>
</author>
<author>
<name sortKey="Zamora, M Pilar" sort="Zamora, M Pilar" uniqKey="Zamora M" first="M Pilar" last="Zamora">M Pilar Zamora</name>
<affiliation wicri:level="1">
<nlm:aff id="I27">Servicio de Oncología Médica, Hospital Universitario La Paz, Paseo de la Castellana, 261, 28046 Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Servicio de Oncología Médica, Hospital Universitario La Paz, Paseo de la Castellana, 261, 28046 Madrid</wicri:regionArea>
<placeName>
<settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
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</affiliation>
</author>
<author>
<name sortKey="Arias Perez, Jose Ignacio" sort="Arias Perez, Jose Ignacio" uniqKey="Arias Perez J" first="Jose Ignacio" last="Arias Perez">Jose Ignacio Arias Perez</name>
<affiliation wicri:level="1">
<nlm:aff id="I28">Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Avda. Dres. Fernández Vega, 107 Oviedo, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Avda. Dres. Fernández Vega, 107 Oviedo</wicri:regionArea>
<wicri:noRegion>107 Oviedo</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name>
<affiliation wicri:level="1">
<nlm:aff id="I29">Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Calle de Melchor Fernandez Almagro, 3, 28029 Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Calle de Melchor Fernandez Almagro, 3, 28029 Madrid</wicri:regionArea>
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<settlement type="city">Madrid</settlement>
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</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="I30">Centro de Investigación en Red de Enfermedades Raras (CIBERER), Calle de Melchor Fernandez Almagro, 3, 28029 Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Centro de Investigación en Red de Enfermedades Raras (CIBERER), Calle de Melchor Fernandez Almagro, 3, 28029 Madrid</wicri:regionArea>
<placeName>
<settlement type="city">Madrid</settlement>
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</affiliation>
</author>
<author>
<name sortKey="Bernstein, Leslie" sort="Bernstein, Leslie" uniqKey="Bernstein L" first="Leslie" last="Bernstein">Leslie Bernstein</name>
<affiliation wicri:level="2">
<nlm:aff id="I31">Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA</wicri:regionArea>
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<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name>
<affiliation wicri:level="1">
<nlm:aff id="I32">Department of Epidemiology, School of Medicine, 224 Irvine Hall, University of California Irvine, Irvine, California 92697-7550, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, School of Medicine, 224 Irvine Hall, University of California Irvine, Irvine, California 92697-7550</wicri:regionArea>
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</affiliation>
</author>
<author>
<name sortKey="Ziogas, Argyrios" sort="Ziogas, Argyrios" uniqKey="Ziogas A" first="Argyrios" last="Ziogas">Argyrios Ziogas</name>
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<nlm:aff id="I32">Department of Epidemiology, School of Medicine, 224 Irvine Hall, University of California Irvine, Irvine, California 92697-7550, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, School of Medicine, 224 Irvine Hall, University of California Irvine, Irvine, California 92697-7550</wicri:regionArea>
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</affiliation>
</author>
<author>
<name sortKey="Clarke Dur, Christina" sort="Clarke Dur, Christina" uniqKey="Clarke Dur C" first="Christina" last="Clarke Dur">Christina Clarke Dur</name>
<affiliation wicri:level="1">
<nlm:aff id="I33">Cancer Prevention Institute of California, 2201 Walnut Avenue, Suite 300, Fremont, California 95438, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cancer Prevention Institute of California, 2201 Walnut Avenue, Suite 300, Fremont, California 95438</wicri:regionArea>
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</affiliation>
</author>
<author>
<name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name>
<affiliation wicri:level="3">
<nlm:aff id="I34">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg</wicri:regionArea>
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<region type="land" nuts="1">Bade-Wurtemberg</region>
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</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="I35">German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69121 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69121 Heidelberg</wicri:regionArea>
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<region type="land" nuts="1">Bade-Wurtemberg</region>
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</affiliation>
</author>
<author>
<name sortKey="Muller, Heiko" sort="Muller, Heiko" uniqKey="Muller H" first="Heiko" last="Müller">Heiko Müller</name>
<affiliation wicri:level="3">
<nlm:aff id="I34">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg</wicri:regionArea>
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<region type="land" nuts="1">Bade-Wurtemberg</region>
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</affiliation>
</author>
<author>
<name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name>
<affiliation wicri:level="3">
<nlm:aff id="I34">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Dieffenbach, Aida Karina" sort="Dieffenbach, Aida Karina" uniqKey="Dieffenbach A" first="Aida Karina" last="Dieffenbach">Aida Karina Dieffenbach</name>
<affiliation wicri:level="3">
<nlm:aff id="I34">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="I35">German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69121 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69121 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name>
<affiliation wicri:level="3">
<nlm:aff id="I36">Clinic of Gynecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Ismaninger Strasse 22, D-81675 Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Clinic of Gynecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Ismaninger Strasse 22, D-81675 Munich</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Heil, Joerg" sort="Heil, Joerg" uniqKey="Heil J" first="Joerg" last="Heil">Joerg Heil</name>
<affiliation wicri:level="3">
<nlm:aff id="I18">Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Bartram, Claus R" sort="Bartram, Claus R" uniqKey="Bartram C" first="Claus R" last="Bartram">Claus R. Bartram</name>
<affiliation wicri:level="3">
<nlm:aff id="I37">Institute of Human Genetics, University of Heidelberg, Im Neuenheimer Feld 366, 69121 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Heidelberg, Im Neuenheimer Feld 366, 69121 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K" last="Schmutzler">Rita K. Schmutzler</name>
<affiliation wicri:level="3">
<nlm:aff id="I38">Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, Center of Molecular Medicine Cologne (CMMC), University Hospital of Cologne, ZMMK-Forschungsgebäude, Robert-Koch-Strasse 21, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, Center of Molecular Medicine Cologne (CMMC), University Hospital of Cologne, ZMMK-Forschungsgebäude, Robert-Koch-Strasse 21, 50931 Cologne</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Cologne</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name>
<affiliation wicri:level="3">
<nlm:aff id="I39">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Robert Bosch Stiftung GmbH, Heidehofstrasse 31, 70184 Stuttgart, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Robert Bosch Stiftung GmbH, Heidehofstrasse 31, 70184 Stuttgart</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Stuttgart</region>
<settlement type="city">Stuttgart</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="I40">University of Tübingen, Geschwister-Scholl-Platz, 72074 Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University of Tübingen, Geschwister-Scholl-Platz, 72074 Tübingen</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Justenhoven, Christina" sort="Justenhoven, Christina" uniqKey="Justenhoven C" first="Christina" last="Justenhoven">Christina Justenhoven</name>
<affiliation wicri:level="3">
<nlm:aff id="I39">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Robert Bosch Stiftung GmbH, Heidehofstrasse 31, 70184 Stuttgart, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Robert Bosch Stiftung GmbH, Heidehofstrasse 31, 70184 Stuttgart</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Stuttgart</region>
<settlement type="city">Stuttgart</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="I40">University of Tübingen, Geschwister-Scholl-Platz, 72074 Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University of Tübingen, Geschwister-Scholl-Platz, 72074 Tübingen</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name>
<affiliation wicri:level="3">
<nlm:aff id="I41">Department of Internal Medicine, Evangelische Kliniken Bonn GGmbH, Johanniter Krankenhaus, 53113 Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Internal Medicine, Evangelische Kliniken Bonn GGmbH, Johanniter Krankenhaus, 53113 Bonn</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Breast Cancer Research : BCR</title>
<idno type="ISSN">1465-5411</idno>
<idno type="eISSN">1465-542X</idno>
<imprint>
<date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass></textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<sec>
<title>Introduction</title>
<p>We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the
<italic>CYP3A</italic>
locus (7q22.1), was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age ≤50 years.</p>
</sec>
<sec>
<title>Methods</title>
<p>We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Association Consortium. Genotyping of rs10235235 was conducted using a custom Illumina Infinium array. Stratified analyses were conducted to determine whether this association was modified by age at diagnosis, ethnicity, age at menarche or tumor characteristics.</p>
</sec>
<sec>
<title>Results</title>
<p>We confirmed the association of rs10235235 with breast cancer risk for women of European ancestry but found no evidence that this association differed with age at diagnosis. Heterozygote and homozygote odds ratios (ORs) were OR = 0.98 (95% CI 0.94, 1.01;
<italic>P</italic>
= 0.2) and OR = 0.80 (95% CI 0.69, 0.93;
<italic>P</italic>
= 0.004), respectively (
<italic>P</italic>
<sub>trend</sub>
= 0.02). There was no evidence of effect modification by tumor characteristics. rs10235235 was, however, associated with age at menarche in controls (
<italic>P</italic>
<sub>trend</sub>
= 0.005) but not cases (
<italic>P</italic>
<sub>trend</sub>
= 0.97). Consequently the association between rs10235235 and breast cancer risk differed according to age at menarche (
<italic>P</italic>
<sub>het</sub>
= 0.02); the rare allele of rs10235235 was associated with a reduction in breast cancer risk for women who had their menarche age ≥15 years (OR
<sub>het</sub>
= 0.84, 95% CI 0.75, 0.94; OR
<sub>hom</sub>
= 0.81, 95% CI 0.51, 1.30;
<italic>P</italic>
<sub>trend</sub>
= 0.002) but not for those who had their menarche age ≤11 years (OR
<sub>het</sub>
= 1.06, 95% CI 0.95, 1.19, OR
<sub>hom</sub>
= 1.07, 95% CI 0.67, 1.72;
<italic>P</italic>
<sub>trend</sub>
= 0.29).</p>
</sec>
<sec>
<title>Conclusions</title>
<p>To our knowledge rs10235235 is the first single nucleotide polymorphism to be associated with both breast cancer risk and age at menarche consistent with the well-documented association between later age at menarche and a reduction in breast cancer risk. These associations are likely mediated via an effect on circulating hormone levels.</p>
</sec>
</div>
</front>
<back>
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<journal-id journal-id-type="nlm-ta">Breast Cancer Res</journal-id>
<journal-id journal-id-type="iso-abbrev">Breast Cancer Res</journal-id>
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<article-id pub-id-type="pmc">4522594</article-id>
<article-id pub-id-type="publisher-id">bcr3662</article-id>
<article-id pub-id-type="doi">10.1186/bcr3662</article-id>
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<contrib contrib-type="author" id="A26">
<name>
<surname>Miller</surname>
<given-names>Nicola</given-names>
</name>
<xref ref-type="aff" rid="I17">17</xref>
<email>nicola.miller@nuigalway.ie</email>
</contrib>
<contrib contrib-type="author" id="A27">
<name>
<surname>Burwinkel</surname>
<given-names>Barbara</given-names>
</name>
<xref ref-type="aff" rid="I18">18</xref>
<xref ref-type="aff" rid="I19">19</xref>
<email>Barbara.Burwinkel@med.uni-heidelberg.de</email>
</contrib>
<contrib contrib-type="author" id="A28">
<name>
<surname>Marme</surname>
<given-names>Frederik</given-names>
</name>
<xref ref-type="aff" rid="I18">18</xref>
<email>frederikmarme@gmail.com</email>
</contrib>
<contrib contrib-type="author" id="A29">
<name>
<surname>Schneeweiss</surname>
<given-names>Andreas</given-names>
</name>
<xref ref-type="aff" rid="I18">18</xref>
<email>Andreas.Schneeweiss@med.uni-heidelberg.de</email>
</contrib>
<contrib contrib-type="author" id="A30">
<name>
<surname>Sohn</surname>
<given-names>Christof</given-names>
</name>
<xref ref-type="aff" rid="I18">18</xref>
<xref ref-type="aff" rid="I20">20</xref>
<email>Christof.Sohn@med.uni-heidelberg.de</email>
</contrib>
<contrib contrib-type="author" id="A31">
<name>
<surname>Guénel</surname>
<given-names>Pascal</given-names>
</name>
<xref ref-type="aff" rid="I21">21</xref>
<xref ref-type="aff" rid="I22">22</xref>
<email>pascal.guenel@inserm.fr</email>
</contrib>
<contrib contrib-type="author" id="A32">
<name>
<surname>Truong</surname>
<given-names>Therese</given-names>
</name>
<xref ref-type="aff" rid="I21">21</xref>
<xref ref-type="aff" rid="I22">22</xref>
<email>therese.truong@inserm.fr</email>
</contrib>
<contrib contrib-type="author" id="A33">
<name>
<surname>Cordina</surname>
<given-names>Emilie</given-names>
</name>
<xref ref-type="aff" rid="I21">21</xref>
<xref ref-type="aff" rid="I22">22</xref>
<email>emilie.cordina@inserm.fr</email>
</contrib>
<contrib contrib-type="author" id="A34">
<name>
<surname>Menegaux</surname>
<given-names>Florence</given-names>
</name>
<xref ref-type="aff" rid="I21">21</xref>
<xref ref-type="aff" rid="I22">22</xref>
<email>florence.menegaux@inserm.fr</email>
</contrib>
<contrib contrib-type="author" id="A35">
<name>
<surname>Bojesen</surname>
<given-names>Stig E</given-names>
</name>
<xref ref-type="aff" rid="I23">23</xref>
<xref ref-type="aff" rid="I24">24</xref>
<email>stig.egil.bojesen@regionh.dk</email>
</contrib>
<contrib contrib-type="author" id="A36">
<name>
<surname>Nordestgaard</surname>
<given-names>Børge G</given-names>
</name>
<xref ref-type="aff" rid="I23">23</xref>
<xref ref-type="aff" rid="I24">24</xref>
<email>brno@heh.regionh.dk</email>
</contrib>
<contrib contrib-type="author" id="A37">
<name>
<surname>Flyger</surname>
<given-names>Henrik</given-names>
</name>
<xref ref-type="aff" rid="I25">25</xref>
<email>Henrik.Flyger@regionh.dk</email>
</contrib>
<contrib contrib-type="author" id="A38">
<name>
<surname>Milne</surname>
<given-names>Roger</given-names>
</name>
<xref ref-type="aff" rid="I26">26</xref>
<email>roger.milne@cancervic.org.au</email>
</contrib>
<contrib contrib-type="author" id="A39">
<name>
<surname>Zamora</surname>
<given-names>M Pilar</given-names>
</name>
<xref ref-type="aff" rid="I27">27</xref>
<email>zamorapilar@gmail.com</email>
</contrib>
<contrib contrib-type="author" id="A40">
<name>
<surname>Arias Perez</surname>
<given-names>Jose Ignacio</given-names>
</name>
<xref ref-type="aff" rid="I28">28</xref>
<email>jiarias@msn.com</email>
</contrib>
<contrib contrib-type="author" id="A41">
<name>
<surname>Benitez</surname>
<given-names>Javier</given-names>
</name>
<xref ref-type="aff" rid="I29">29</xref>
<xref ref-type="aff" rid="I30">30</xref>
<email>jbenitez@cnio.es</email>
</contrib>
<contrib contrib-type="author" id="A42">
<name>
<surname>Bernstein</surname>
<given-names>Leslie</given-names>
</name>
<xref ref-type="aff" rid="I31">31</xref>
<email>LBernstein@coh.org</email>
</contrib>
<contrib contrib-type="author" id="A43">
<name>
<surname>Anton-Culver</surname>
<given-names>Hoda</given-names>
</name>
<xref ref-type="aff" rid="I32">32</xref>
<email>hantoncu@uci.edu</email>
</contrib>
<contrib contrib-type="author" id="A44">
<name>
<surname>Ziogas</surname>
<given-names>Argyrios</given-names>
</name>
<xref ref-type="aff" rid="I32">32</xref>
<email>aziogas@uci.edu</email>
</contrib>
<contrib contrib-type="author" id="A45">
<name>
<surname>Clarke Dur</surname>
<given-names>Christina</given-names>
</name>
<xref ref-type="aff" rid="I33">33</xref>
<email>tina@CPIC.org</email>
</contrib>
<contrib contrib-type="author" id="A46">
<name>
<surname>Brenner</surname>
<given-names>Hermann</given-names>
</name>
<xref ref-type="aff" rid="I34">34</xref>
<xref ref-type="aff" rid="I35">35</xref>
<email>h.brenner@dkfz.de</email>
</contrib>
<contrib contrib-type="author" id="A47">
<name>
<surname>Müller</surname>
<given-names>Heiko</given-names>
</name>
<xref ref-type="aff" rid="I34">34</xref>
<email>h.mueller@dkfz.de</email>
</contrib>
<contrib contrib-type="author" id="A48">
<name>
<surname>Arndt</surname>
<given-names>Volker</given-names>
</name>
<xref ref-type="aff" rid="I34">34</xref>
<email>v.arndt@dkfz.de</email>
</contrib>
<contrib contrib-type="author" id="A49">
<name>
<surname>Dieffenbach</surname>
<given-names>Aida Karina</given-names>
</name>
<xref ref-type="aff" rid="I34">34</xref>
<xref ref-type="aff" rid="I35">35</xref>
<email>A.Dieffenbach@dkfz-heidelberg.de</email>
</contrib>
<contrib contrib-type="author" id="A50">
<name>
<surname>Meindl</surname>
<given-names>Alfons</given-names>
</name>
<xref ref-type="aff" rid="I36">36</xref>
<email>alfons.meindl@lrz.tu-muenchen.de</email>
</contrib>
<contrib contrib-type="author" id="A51">
<name>
<surname>Heil</surname>
<given-names>Joerg</given-names>
</name>
<xref ref-type="aff" rid="I18">18</xref>
<email>joerg.heil@med.uni-heidelberg.de</email>
</contrib>
<contrib contrib-type="author" id="A52">
<name>
<surname>Bartram</surname>
<given-names>Claus R</given-names>
</name>
<xref ref-type="aff" rid="I37">37</xref>
<email>cr_bartram@med.uni-heidelberg.de</email>
</contrib>
<contrib contrib-type="author" id="A53">
<name>
<surname>Schmutzler</surname>
<given-names>Rita K</given-names>
</name>
<xref ref-type="aff" rid="I38">38</xref>
<email>rita.schmutzler@uk-koeln.de</email>
</contrib>
<contrib contrib-type="author" id="A54">
<name>
<surname>Brauch</surname>
<given-names>Hiltrud</given-names>
</name>
<xref ref-type="aff" rid="I39">39</xref>
<xref ref-type="aff" rid="I40">40</xref>
<email>hiltrud.brauch@ikp-stuttgart.de</email>
</contrib>
<contrib contrib-type="author" id="A55">
<name>
<surname>Justenhoven</surname>
<given-names>Christina</given-names>
</name>
<xref ref-type="aff" rid="I39">39</xref>
<xref ref-type="aff" rid="I40">40</xref>
<email>christina.justenhoven@bioscientia.de</email>
</contrib>
<contrib contrib-type="author" id="A56">
<name>
<surname>Ko</surname>
<given-names>Yon-Dschun</given-names>
</name>
<xref ref-type="aff" rid="I41">41</xref>
<email>Yon-Dschun.Ko@ek-bonn.de</email>
</contrib>
<on-behalf-of>The GENICA (Gene Environment Interaction and Breast Cancer in Germany) Network
<xref ref-type="corresp" rid="d33e527"></xref>
</on-behalf-of>
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<contrib-group>
<contrib contrib-type="author" id="A58">
<name>
<surname>Nevanlinna</surname>
<given-names>Heli</given-names>
</name>
<xref ref-type="aff" rid="I42">42</xref>
<email>Heli.Nevanlinna@hus.fi</email>
</contrib>
<contrib contrib-type="author" id="A59">
<name>
<surname>Muranen</surname>
<given-names>Taru A</given-names>
</name>
<xref ref-type="aff" rid="I42">42</xref>
<email>taru.a.muranen@helsinki.fi</email>
</contrib>
<contrib contrib-type="author" id="A60">
<name>
<surname>Aittomäki</surname>
<given-names>Kristiina</given-names>
</name>
<xref ref-type="aff" rid="I43">43</xref>
<email>kristiina.aittomaki@hus.fi</email>
</contrib>
<contrib contrib-type="author" id="A61">
<name>
<surname>Blomqvist</surname>
<given-names>Carl</given-names>
</name>
<xref ref-type="aff" rid="I44">44</xref>
<email>carl.blomqvist@helsinki.fi</email>
</contrib>
<contrib contrib-type="author" id="A62">
<name>
<surname>Matsuo</surname>
<given-names>Keitaro</given-names>
</name>
<xref ref-type="aff" rid="I45">45</xref>
<email>kmatsuo@aichi-cc.jp</email>
</contrib>
<contrib contrib-type="author" id="A63">
<name>
<surname>Dörk</surname>
<given-names>Thilo</given-names>
</name>
<xref ref-type="aff" rid="I46">46</xref>
<email>doerk.thilo@mh-hannover.de</email>
</contrib>
<contrib contrib-type="author" id="A64">
<name>
<surname>Bogdanova</surname>
<given-names>Natalia V</given-names>
</name>
<xref ref-type="aff" rid="I47">47</xref>
<email>nata_bogdanova@yahoo.com</email>
</contrib>
<contrib contrib-type="author" id="A65">
<name>
<surname>Antonenkova</surname>
<given-names>Natalia N</given-names>
</name>
<xref ref-type="aff" rid="I48">48</xref>
<email>antonenkova.natalia.omd@tut.by</email>
</contrib>
<contrib contrib-type="author" id="A66">
<name>
<surname>Lindblom</surname>
<given-names>Annika</given-names>
</name>
<xref ref-type="aff" rid="I49">49</xref>
<email>Annika.Lindblom@ki.se</email>
</contrib>
<contrib contrib-type="author" id="A67">
<name>
<surname>Mannermaa</surname>
<given-names>Arto</given-names>
</name>
<xref ref-type="aff" rid="I50">50</xref>
<xref ref-type="aff" rid="I51">51</xref>
<xref ref-type="aff" rid="I52">52</xref>
<email>arto.mannermaa@uef.fi</email>
</contrib>
<contrib contrib-type="author" id="A68">
<name>
<surname>Kataja</surname>
<given-names>Vesa</given-names>
</name>
<xref ref-type="aff" rid="I50">50</xref>
<xref ref-type="aff" rid="I51">51</xref>
<xref ref-type="aff" rid="I53">53</xref>
<email>vesa.kataja@kuh.fi</email>
</contrib>
<contrib contrib-type="author" id="A69">
<name>
<surname>Kosma</surname>
<given-names>Veli-Matti</given-names>
</name>
<xref ref-type="aff" rid="I50">50</xref>
<xref ref-type="aff" rid="I51">51</xref>
<xref ref-type="aff" rid="I52">52</xref>
<email>veli-matti.kosma@uef.fi</email>
</contrib>
<contrib contrib-type="author" id="A70">
<name>
<surname>Hartikainen</surname>
<given-names>Jaana M</given-names>
</name>
<xref ref-type="aff" rid="I50">50</xref>
<xref ref-type="aff" rid="I51">51</xref>
<xref ref-type="aff" rid="I52">52</xref>
<email>jaana.hartikainen@uef.fi</email>
</contrib>
<contrib contrib-type="author" id="A71">
<name>
<surname>Chenevix-Trench</surname>
<given-names>Georgia</given-names>
</name>
<xref ref-type="aff" rid="I54">54</xref>
<email>Georgia.Trench@qimr.edu.au</email>
</contrib>
<contrib contrib-type="author" id="A72">
<name>
<surname>Beesley</surname>
<given-names>Jonathan</given-names>
</name>
<xref ref-type="aff" rid="I54">54</xref>
<email>Jonathan.Beesley@qimr.edu.au</email>
</contrib>
<on-behalf-of>kConFab Investigators
<xref ref-type="corresp" rid="d33e667"></xref>
</on-behalf-of>
</contrib-group>
<contrib-group>
<on-behalf-of>Australian Ovarian Cancer Study Group
<xref ref-type="corresp" rid="d33e670"></xref>
</on-behalf-of>
</contrib-group>
<contrib-group>
<contrib contrib-type="author" id="A75">
<name>
<surname>Wu</surname>
<given-names>Anna H</given-names>
</name>
<xref ref-type="aff" rid="I55">55</xref>
<email>Anna.Wu@med.usc.edu</email>
</contrib>
<contrib contrib-type="author" id="A76">
<name>
<surname>Van den Berg</surname>
<given-names>David</given-names>
</name>
<xref ref-type="aff" rid="I55">55</xref>
<email>dvandenb@usc.edu</email>
</contrib>
<contrib contrib-type="author" id="A77">
<name>
<surname>Tseng</surname>
<given-names>Chiu-Chen</given-names>
</name>
<xref ref-type="aff" rid="I55">55</xref>
<email>Chiu-chen.Tseng@med.usc.edu</email>
</contrib>
<contrib contrib-type="author" id="A78">
<name>
<surname>Lambrechts</surname>
<given-names>Diether</given-names>
</name>
<xref ref-type="aff" rid="I56">56</xref>
<xref ref-type="aff" rid="I57">57</xref>
<email>Diether.Lambrechts@vib-kuleuven.be</email>
</contrib>
<contrib contrib-type="author" id="A79">
<name>
<surname>Smeets</surname>
<given-names>Dominiek</given-names>
</name>
<xref ref-type="aff" rid="I56">56</xref>
<xref ref-type="aff" rid="I57">57</xref>
<email>Dominiek.Smeets@vib-kuleuven.be</email>
</contrib>
<contrib contrib-type="author" id="A80">
<name>
<surname>Neven</surname>
<given-names>Patrick</given-names>
</name>
<xref ref-type="aff" rid="I58">58</xref>
<email>Patrick.Neven@uzleuven.be</email>
</contrib>
<contrib contrib-type="author" id="A81">
<name>
<surname>Wildiers</surname>
<given-names>Hans</given-names>
</name>
<xref ref-type="aff" rid="I58">58</xref>
<email>Hans.Wildiers@uzleuven.be</email>
</contrib>
<contrib contrib-type="author" id="A82">
<name>
<surname>Chang-Claude</surname>
<given-names>Jenny</given-names>
</name>
<xref ref-type="aff" rid="I59">59</xref>
<email>j.chang-claude@dkfz-heidelberg.de</email>
</contrib>
<contrib contrib-type="author" id="A83">
<name>
<surname>Rudolph</surname>
<given-names>Anja</given-names>
</name>
<xref ref-type="aff" rid="I59">59</xref>
<email>a.rudolph@dkfz.de</email>
</contrib>
<contrib contrib-type="author" id="A84">
<name>
<surname>Nickels</surname>
<given-names>Stefan</given-names>
</name>
<xref ref-type="aff" rid="I59">59</xref>
<email>s.nickels@dkfz.de</email>
</contrib>
<contrib contrib-type="author" id="A85">
<name>
<surname>Flesch-Janys</surname>
<given-names>Dieter</given-names>
</name>
<xref ref-type="aff" rid="I60">60</xref>
<xref ref-type="aff" rid="I61">61</xref>
<email>flesch@uke.uni-hamburg.de</email>
</contrib>
<contrib contrib-type="author" id="A86">
<name>
<surname>Radice</surname>
<given-names>Paolo</given-names>
</name>
<xref ref-type="aff" rid="I62">62</xref>
<email>paolo.radice@istitutotumori.mi.it</email>
</contrib>
<contrib contrib-type="author" id="A87">
<name>
<surname>Peterlongo</surname>
<given-names>Paolo</given-names>
</name>
<xref ref-type="aff" rid="I62">62</xref>
<xref ref-type="aff" rid="I63">63</xref>
<email>paolo.peterlongo@ifom.eu</email>
</contrib>
<contrib contrib-type="author" id="A88">
<name>
<surname>Bonanni</surname>
<given-names>Bernardo</given-names>
</name>
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<email>bernardo.bonanni@ieo.it</email>
</contrib>
<contrib contrib-type="author" id="A89">
<name>
<surname>Pensotti</surname>
<given-names>Valeria</given-names>
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<xref ref-type="aff" rid="I63">63</xref>
<xref ref-type="aff" rid="I65">65</xref>
<email>valeria.pensotti@ifom.eu</email>
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<contrib contrib-type="author" id="A90">
<name>
<surname>Couch</surname>
<given-names>Fergus J</given-names>
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<email>couch.fergus@mayo.edu</email>
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<contrib contrib-type="author" id="A91">
<name>
<surname>Olson</surname>
<given-names>Janet E</given-names>
</name>
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<email>olsonj@mayo.edu</email>
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<contrib contrib-type="author" id="A92">
<name>
<surname>Wang</surname>
<given-names>Xianshu</given-names>
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<email>wang.xianshu@mayo.edu</email>
</contrib>
<contrib contrib-type="author" id="A93">
<name>
<surname>Fredericksen</surname>
<given-names>Zachary</given-names>
</name>
<xref ref-type="aff" rid="I67">67</xref>
<email>Zach.Fredericksen@northerntool.com</email>
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<contrib contrib-type="author" id="A94">
<name>
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<given-names>Vernon S</given-names>
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<email>pankratz.vernon@mayo.edu</email>
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<contrib contrib-type="author" id="A95">
<name>
<surname>Giles</surname>
<given-names>Graham G</given-names>
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<xref ref-type="aff" rid="I68">68</xref>
<email>Graham.Giles@cancervic.org.au</email>
</contrib>
<contrib contrib-type="author" id="A96">
<name>
<surname>Severi</surname>
<given-names>Gianluca</given-names>
</name>
<xref ref-type="aff" rid="I6">6</xref>
<xref ref-type="aff" rid="I68">68</xref>
<email>Gianluca.severi@cancervic.org.au</email>
</contrib>
<contrib contrib-type="author" id="A97">
<name>
<surname>Baglietto</surname>
<given-names>Laura</given-names>
</name>
<xref ref-type="aff" rid="I6">6</xref>
<xref ref-type="aff" rid="I68">68</xref>
<email>Laura.baglietto@cancervic.org.au</email>
</contrib>
<contrib contrib-type="author" id="A98">
<name>
<surname>Haiman</surname>
<given-names>Chris</given-names>
</name>
<xref ref-type="aff" rid="I56">56</xref>
<email>Christopher.Haiman@med.usc.edu</email>
</contrib>
<contrib contrib-type="author" id="A99">
<name>
<surname>Simard</surname>
<given-names>Jacques</given-names>
</name>
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<email>jacques.simard@crchul.ulaval.ca</email>
</contrib>
<contrib contrib-type="author" id="A100">
<name>
<surname>Goldberg</surname>
<given-names>Mark S</given-names>
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<email>mark.goldberg@mcgill.ca</email>
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<contrib contrib-type="author" id="A101">
<name>
<surname>Labrèche</surname>
<given-names>France</given-names>
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<xref ref-type="aff" rid="I70">70</xref>
<email>France.Labreche@irsst.qc.ca</email>
</contrib>
<contrib contrib-type="author" id="A102">
<name>
<surname>Dumont</surname>
<given-names>Martine</given-names>
</name>
<xref ref-type="aff" rid="I71">71</xref>
<email>martine.dumont@crchul.ulaval.ca</email>
</contrib>
<contrib contrib-type="author" id="A103">
<name>
<surname>Soucy</surname>
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<given-names>Alan</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<xref ref-type="aff" rid="I2">2</xref>
<email>Alan.Ashworth@icr.ac.uk</email>
</contrib>
<contrib contrib-type="author" id="A182">
<name>
<surname>Swerdlow</surname>
<given-names>Anthony J</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<xref ref-type="aff" rid="I2">2</xref>
<xref ref-type="aff" rid="I4">4</xref>
<email>Anthony.Swerdlow@icr.ac.uk</email>
</contrib>
<contrib contrib-type="author" id="A183">
<name>
<surname>Peto</surname>
<given-names>Julian</given-names>
</name>
<xref ref-type="aff" rid="I3">3</xref>
<email>Julian.Peto@lshtm.ac.uk</email>
</contrib>
<contrib contrib-type="author" equal-contrib="yes" id="A184">
<name>
<surname>dos Santos Silva</surname>
<given-names>Isabel</given-names>
</name>
<xref ref-type="aff" rid="I3">3</xref>
<email>Isabel.Silva@lshtm.ac.uk</email>
</contrib>
<contrib contrib-type="author" equal-contrib="yes" id="A185">
<name>
<surname>Fletcher</surname>
<given-names>Olivia</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<xref ref-type="aff" rid="I2">2</xref>
<email>Olivia.Fletcher@icr.ac.uk</email>
</contrib>
</contrib-group>
<aff id="I1">
<label>1</label>
Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK</aff>
<aff id="I2">
<label>2</label>
Division of Breast Cancer Research, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK</aff>
<aff id="I3">
<label>3</label>
Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK</aff>
<aff id="I4">
<label>4</label>
Division of Genetics and Epidemiology, The Institute of Cancer Research, 15 Cotswold Road, Belmont, Sutton, Surrey SM2 5NG, UK</aff>
<aff id="I5">
<label>5</label>
The Academic Department of Biochemistry, The Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK</aff>
<aff id="I6">
<label>6</label>
Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, 1-100 Gratton Street, Parkville, Melbourne, Victoria 3010, Australia</aff>
<aff id="I7">
<label>7</label>
Genetic Epidemiology Department, Department of Pathology, The University of Melbourne, 1-100 Gratton Street, Parkville, Melbourne, Victoria 3010, Australia</aff>
<aff id="I8">
<label>8</label>
Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands</aff>
<aff id="I9">
<label>9</label>
Sanquin, Radboud Universiteit Nijmegen, 6525 GA, Nijmegen, The Netherlands</aff>
<aff id="I10">
<label>10</label>
Warwick Medical School, University of Warwick, Coventry CV4 7AJ, UK</aff>
<aff id="I11">
<label>11</label>
University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Postfach 2306, D-91012 Erlangen, Germany</aff>
<aff id="I12">
<label>12</label>
David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, University of California, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA</aff>
<aff id="I13">
<label>13</label>
Institute of Human Genetics, Friedrich Alexander University Erlangen- Nuremberg, Schlossplatz 4, 91054 Erlangen, Germany</aff>
<aff id="I14">
<label>14</label>
Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy’s & St. Thomas’ NHS Foundation Trust in partnership with King’s College London, Guy’s Hospital, Great Maze Pond, London SE1 9RT, UK</aff>
<aff id="I15">
<label>15</label>
Welcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK</aff>
<aff id="I16">
<label>16</label>
Oxford Biomedical Research Centre, University of Oxford, The Churchill Hospital, Old Road, Headington OX3 7LE Oxford, UK</aff>
<aff id="I17">
<label>17</label>
Surgery, Clinical Science Institute, Galway University Hospital and National University of Ireland, University Road, Galway, Ireland</aff>
<aff id="I18">
<label>18</label>
Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg, Germany</aff>
<aff id="I19">
<label>19</label>
Unit Molecular Epidemiology C080, German Cancer Research Center, DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany</aff>
<aff id="I20">
<label>20</label>
National Center for Tumor Diseases, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany</aff>
<aff id="I21">
<label>21</label>
Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</aff>
<aff id="I22">
<label>22</label>
University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</aff>
<aff id="I23">
<label>23</label>
Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen, Denmark</aff>
<aff id="I24">
<label>24</label>
Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen, Denmark</aff>
<aff id="I25">
<label>25</label>
Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, Herlev, 2730 Copenhagen, Denmark</aff>
<aff id="I26">
<label>26</label>
Genetic and Molecular Epidemiology Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Calle de Melchor Fernandez Almagro, 3, 28029 Madrid, Spain</aff>
<aff id="I27">
<label>27</label>
Servicio de Oncología Médica, Hospital Universitario La Paz, Paseo de la Castellana, 261, 28046 Madrid, Spain</aff>
<aff id="I28">
<label>28</label>
Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Avda. Dres. Fernández Vega, 107 Oviedo, Spain</aff>
<aff id="I29">
<label>29</label>
Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Calle de Melchor Fernandez Almagro, 3, 28029 Madrid, Spain</aff>
<aff id="I30">
<label>30</label>
Centro de Investigación en Red de Enfermedades Raras (CIBERER), Calle de Melchor Fernandez Almagro, 3, 28029 Madrid, Spain</aff>
<aff id="I31">
<label>31</label>
Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA</aff>
<aff id="I32">
<label>32</label>
Department of Epidemiology, School of Medicine, 224 Irvine Hall, University of California Irvine, Irvine, California 92697-7550, USA</aff>
<aff id="I33">
<label>33</label>
Cancer Prevention Institute of California, 2201 Walnut Avenue, Suite 300, Fremont, California 95438, USA</aff>
<aff id="I34">
<label>34</label>
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg, Germany</aff>
<aff id="I35">
<label>35</label>
German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69121 Heidelberg, Germany</aff>
<aff id="I36">
<label>36</label>
Clinic of Gynecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Ismaninger Strasse 22, D-81675 Munich, Germany</aff>
<aff id="I37">
<label>37</label>
Institute of Human Genetics, University of Heidelberg, Im Neuenheimer Feld 366, 69121 Heidelberg, Germany</aff>
<aff id="I38">
<label>38</label>
Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, Center of Molecular Medicine Cologne (CMMC), University Hospital of Cologne, ZMMK-Forschungsgebäude, Robert-Koch-Strasse 21, 50931 Cologne, Germany</aff>
<aff id="I39">
<label>39</label>
Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Robert Bosch Stiftung GmbH, Heidehofstrasse 31, 70184 Stuttgart, Germany</aff>
<aff id="I40">
<label>40</label>
University of Tübingen, Geschwister-Scholl-Platz, 72074 Tübingen, Germany</aff>
<aff id="I41">
<label>41</label>
Department of Internal Medicine, Evangelische Kliniken Bonn GGmbH, Johanniter Krankenhaus, 53113 Bonn, Germany</aff>
<aff id="I42">
<label>42</label>
Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Haartmaninkatu 2, P.O. Box 140, FIN-00029 Helsinki, Finland</aff>
<aff id="I43">
<label>43</label>
Department of Clinical Genetics, Helsinki University Central Hospital, Haartmaninkatu 2, P.O. Box 140, FIN-00029 Helsinki, Finland</aff>
<aff id="I44">
<label>44</label>
Department of Oncology, Helsinki University Central Hospital, Haartmaninkatu 2, P.O. Box 140, FIN-00029 Helsinki, Finland</aff>
<aff id="I45">
<label>45</label>
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1-1Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan</aff>
<aff id="I46">
<label>46</label>
Department of Obstetrics and Gynaecology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany</aff>
<aff id="I47">
<label>47</label>
Department of Radiation Oncology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany</aff>
<aff id="I48">
<label>48</label>
N.N. Alexandrov Research Institute of Oncology and Medical Radiology, 223040, p. Lesnoy, Minsk, Belarus</aff>
<aff id="I49">
<label>49</label>
Department of Molecular Medicine and Surgery, Karolinska Institutet, Solnavägen 1, 171 77 Solna, Stockholm, Sweden</aff>
<aff id="I50">
<label>50</label>
School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Yliopistonranta 1, P.O. Box 1627 FI-70211 Kuopio, Finland</aff>
<aff id="I51">
<label>51</label>
Biocenter Kuopio, Cancer Center of Eastern Finland, University of Eastern Finland, Yliopistonranta 1, P.O. Box 1627 FI-70211 Kuopio, Finland</aff>
<aff id="I52">
<label>52</label>
Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, P.O. Box 100 FI-70029 Kuopio, Finland</aff>
<aff id="I53">
<label>53</label>
Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, P.O. Box 100 FI-70029 Kuopio, Finland</aff>
<aff id="I54">
<label>54</label>
Department of Genetics, Queensland Institute of Medical Research, 300 Herston Rd, Herston, Brisbane Queensland 4006, Australia</aff>
<aff id="I55">
<label>55</label>
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1975 Zonal Ave, Los Angeles, CA 90033, USA</aff>
<aff id="I56">
<label>56</label>
Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Oude Markt 13 - bus 5005, 3000 Leuven, Belgium</aff>
<aff id="I57">
<label>57</label>
Vesalius Research Center, VIB, Herestraat 49, box 912, Onderwijs & Navorsing 4, Building 404-24, 3000 Leuven, Belgium</aff>
<aff id="I58">
<label>58</label>
Multidisciplinary Breast Center, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium</aff>
<aff id="I59">
<label>59</label>
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany</aff>
<aff id="I60">
<label>60</label>
Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf, Martinistrasse 52, D - 20246 Hamburg, Germany</aff>
<aff id="I61">
<label>61</label>
Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Martinistrasse 52, D - 20246 Hamburg, Germany</aff>
<aff id="I62">
<label>62</label>
Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Via Venezian 1, 20133 Milan, Italy</aff>
<aff id="I63">
<label>63</label>
IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, Italy</aff>
<aff id="I64">
<label>64</label>
Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Via Giuseppe Ripamonti 435, 20141 Milan, Italy</aff>
<aff id="I65">
<label>65</label>
Cogentech Cancer Genetic Test Laboratory, IFOM-IEO Campus, Via Adamello16, 20139 Milan, Italy</aff>
<aff id="I66">
<label>66</label>
Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA</aff>
<aff id="I67">
<label>67</label>
Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA</aff>
<aff id="I68">
<label>68</label>
Cancer Epidemiology Centre, The Cancer Council Victoria, 615 St Kilda Road, Melbourne, Victoria 3004, Australia</aff>
<aff id="I69">
<label>69</label>
Department of Medicine, McGill University and Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital, 687 Pine Avenue West, Montréal, Québec H3A 1A1, Canada</aff>
<aff id="I70">
<label>70</label>
Department of Social and Preventive Medicine and Department of Environmental and Occupational Health at Work, University of Montréal, Marguerite d'Youville Pavilion, 2375 Côte Ste-Catherine, Suite 4095, Montréal, Québec H3T 1A8, Canada</aff>
<aff id="I71">
<label>71</label>
Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2325 Rue de l'Université, Québec City, Québec G1V 0A6, Canada</aff>
<aff id="I72">
<label>72</label>
Breast Cancer Research Unit, University of Malaya Cancer Research Institute, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia</aff>
<aff id="I73">
<label>73</label>
Cancer Research Initiatives Foundation, Sime Darby Medical Centre Subang Jaya, 1, Jalan SS 12 / 1A, 47500 Subang Jaya, Selangor Darul Ehsan, Malaysia</aff>
<aff id="I74">
<label>74</label>
Singapore Eye Research Institute, National University of Singapore, Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore 168751, Singapore</aff>
<aff id="I75">
<label>75</label>
Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, N-0310 Oslo, Norway</aff>
<aff id="I76">
<label>76</label>
Faculty of Medicine (Faculty Division Ahus), University of Oslo, Sogn Arena, Klaus Torgårds vei 3, 2. etg, 0372 Oslo, Norway</aff>
<aff id="I77">
<label>77</label>
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, 1161 21st Ave S # T1217, Nashville, TN 37232, USA</aff>
<aff id="I78">
<label>78</label>
Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu University Hospital, Kajaanintie 50, 90220 Oulu, Finland</aff>
<aff id="I79">
<label>79</label>
Department of Oncology, Oulu University Hospital, University of Oulu, Kajaanintie 50, 90220 Oulu, Finland</aff>
<aff id="I80">
<label>80</label>
Department of Surgery, Oulu University Hospital, University of Oulu, Kajaanintie 50, 90220 Oulu, Finland</aff>
<aff id="I81">
<label>81</label>
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 982 - 600 University Avenue, Toronto, Ontario M5G 1X5, Canada</aff>
<aff id="I82">
<label>82</label>
Department of Molecular Genetics, University of Toronto, Medical Science Building, Room 4386, 1 King's College Cir, Toronto, Ontario M5S 1A8, Canada</aff>
<aff id="I83">
<label>83</label>
Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, 6th floor, 155 College St, Toronto, Ontario M5T 3M7, Canada</aff>
<aff id="I84">
<label>84</label>
Ontario Cancer Genetics Network, 620 University Avenue, Toronto, Ontario M5G 2L7, Canada</aff>
<aff id="I85">
<label>85</label>
Department of Laboratory Medicine and Pathobiology, University of Toronto, Medical Sciences Building, 6th Floor, 1 King's College Cir, Toronto, Ontario M5S 1A8, Canada</aff>
<aff id="I86">
<label>86</label>
University Health Network, R. Fraser Elliott Building, 1st Floor, 190 Elizabeth St., Toronto, Ontario M5G 2C4, Canada</aff>
<aff id="I87">
<label>87</label>
Department of Human Genetics & Department of Pathology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands</aff>
<aff id="I88">
<label>88</label>
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Rockville, MD 20850, USA</aff>
<aff id="I89">
<label>89</label>
Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology, Roentena 5, 02-781 Warsaw, Poland</aff>
<aff id="I90">
<label>90</label>
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solnavägen 1, Stockholm 17177, Sweden</aff>
<aff id="I91">
<label>91</label>
Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Groene Hilledijk 301, Rotterdam, EA, 3075, The Netherlands</aff>
<aff id="I92">
<label>92</label>
Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, Groene Hilledijk 301, 3075 EA, Rotterdam, The Netherlands</aff>
<aff id="I93">
<label>93</label>
Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Groene Hilledijk 301, 3075 EA, Rotterdam, The Netherlands</aff>
<aff id="I94">
<label>94</label>
Human Genetics Division, Genome Institute of Singapore, 60 Biopolis St, Singapore 138672, Singapore</aff>
<aff id="I95">
<label>95</label>
Institute for Cancer Studies, Department of Oncology, CRUK/YCR Sheffield Cancer Research Centre, University of Sheffield, 385a Glossop Road, Sheffield S10 2HQ, UK</aff>
<aff id="I96">
<label>96</label>
Academic Unit of Surgical Oncology, Department of Oncology, CRUK/YCR Sheffield Cancer Research Centre, University of Sheffield, 385a Glossop Road, Sheffield S10 2HQ, UK</aff>
<aff id="I97">
<label>97</label>
Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, 385a Glossop Road, Sheffield S10 2HQ, UK</aff>
<aff id="I98">
<label>98</label>
International Epidemiology Institute, 1455 Research Blvd, Rockville, MD 20850, USA</aff>
<aff id="I99">
<label>99</label>
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA</aff>
<aff id="I100">
<label>100</label>
Channing Division of Network Medicine, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA</aff>
<aff id="I101">
<label>101</label>
Dana-Farber/Harvard Cancer Center, 450 Brookline Ave, Boston, MA 02215, USA</aff>
<aff id="I102">
<label>102</label>
Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK</aff>
<aff id="I103">
<label>103</label>
Seoul National University College of Medicine, Yongeon-103 Daehangno, Jongno-gu, Seoul 110-799, Korea</aff>
<aff id="I104">
<label>104</label>
Department of Preventive Medicine, Seoul National University College of Medicine, Yongeon-103 Daehangno, Jongno-gu, Seoul 110-799, Korea</aff>
<aff id="I105">
<label>105</label>
Department of Biomedical Science, Seoul National University Graduate School, Yongeon-103 Daehangno, Jongno-gu, Seoul 110-799, Korea</aff>
<aff id="I106">
<label>106</label>
Cancer Research Institute, Seoul National University, Yongeon-103 Daehangno, Jongno-gu, Seoul 110-799, Korea</aff>
<aff id="I107">
<label>107</label>
Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 1E, Kent Ridge Road, Singapore 119228, Singapore</aff>
<aff id="I108">
<label>108</label>
National University Health System, 1E, Kent Ridge Road, Singapore 119228, Singapore</aff>
<aff id="I109">
<label>109</label>
Saw Swee Hock School of Public Health, National University of Singapore, MD3, 16 Medical Drive, Singapore 117597, Singapore</aff>
<aff id="I110">
<label>110</label>
Division of General Surgery, National University Health System, 1E, Kent Ridge Road, Singapore 119228, Singapore</aff>
<aff id="I111">
<label>111</label>
Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany</aff>
<aff id="I112">
<label>112</label>
Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany</aff>
<aff id="I113">
<label>113</label>
Center for Primary Health Care Research, University of Lund, Paradisgatan 5, SE-221 00 Lund, Malmö, Sweden</aff>
<aff id="I114">
<label>114</label>
Institute of Pathology, Städtisches Klinikum Karlsruhe, Moltkestrasse 90, 76133 Karlsruhe, Germany</aff>
<aff id="I115">
<label>115</label>
Frauenklinik der Stadtklinik Baden-Baden, Balger Strasse 50, 76532 Baden-Württemberg, Germany</aff>
<aff id="I116">
<label>116</label>
Department of Genetics and Pathology, Pomeranian Medical University, Rybacka 1, 70-204 Szczecin, Poland</aff>
<aff id="I117">
<label>117</label>
Postgraduate School of Molecular Medicine, Warsaw Medical University, Żwirki i Wigury 61, 02-091 Warsaw, Poland</aff>
<aff id="I118">
<label>118</label>
National Cancer Institute, 268/1 Rama VI Road, Rajathevi, Bangkok 10400, Thailand</aff>
<aff id="I119">
<label>119</label>
International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372 Lyon, CEDEX 08, France</aff>
<aff id="I120">
<label>120</label>
Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, 410 W. 10th Avenue, Columbus, OH 43210, USA</aff>
<aff id="I121">
<label>121</label>
Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research “Demokritos”, Aghia Paraskevi Attikis 153 10, Athens, Greece</aff>
<aff id="I122">
<label>122</label>
College of Public Health, China Medical University, No.91, Hsueh-Shih Road, Taichung 40402, Taiwan</aff>
<aff id="I123">
<label>123</label>
Institute of Biomedical Sciences, Academia Sinica, 2 Academia Road, Nankang, Taipei 115, Taiwan</aff>
<aff id="I124">
<label>124</label>
Department of Surgery, Tri-Service General Hospital, No.325, Sec.2 Chenggong Road, Taipei City 114, Neihu District, Taiwan</aff>
<aff id="I125">
<label>125</label>
Department of Surgery, National Taiwan University Hospital, No.1, Changde Street, Taipei City 10048, Zhongzheng District, Taiwan</aff>
<aff id="I126">
<label>126</label>
Cancer Center, Kaohsiung Medical University Chung-Ho Memorial Hospital, No.100, Tzyou 1st Road, Kaohsiung 807, Taiwan</aff>
<aff id="I127">
<label>127</label>
Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, No.100, Tzyou 1st Road, Kaohsiung 807, Taiwan</aff>
<aff id="I128">
<label>128</label>
McGill University and Génome Québec Innovation Centre, 740, Dr. Penfield Avenue, Room 7104, Montréal, Québec H3A 0G1, Canada</aff>
<aff id="I129">
<label>129</label>
Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK</aff>
<author-notes>
<corresp id="d33e527">The GENICA (Gene Environment Interaction and Breast Cancer in Germany) Network</corresp>
<corresp id="d33e667">kConFab Investigators</corresp>
<corresp id="d33e670">Australian Ovarian Cancer Study Group</corresp>
</author-notes>
<pub-date pub-type="ppub">
<year>2014</year>
</pub-date>
<pub-date pub-type="epub">
<day>26</day>
<month>5</month>
<year>2014</year>
</pub-date>
<volume>16</volume>
<issue>3</issue>
<fpage>R51</fpage>
<lpage>R51</lpage>
<history>
<date date-type="received">
<day>4</day>
<month>7</month>
<year>2013</year>
</date>
<date date-type="accepted">
<day>24</day>
<month>4</month>
<year>2014</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright © 2014 Johnson et al.; licensee BioMed Central Ltd.</copyright-statement>
<copyright-year>2014</copyright-year>
<copyright-holder>Johnson et al.; licensee BioMed Central Ltd.</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0">
<license-p>This is an open access article distributed under the terms of the Creative Commons Attribution License (
<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<self-uri xlink:href="http://breast-cancer-research.com/content/16/3/R51"></self-uri>
<abstract>
<sec>
<title>Introduction</title>
<p>We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the
<italic>CYP3A</italic>
locus (7q22.1), was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age ≤50 years.</p>
</sec>
<sec>
<title>Methods</title>
<p>We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Association Consortium. Genotyping of rs10235235 was conducted using a custom Illumina Infinium array. Stratified analyses were conducted to determine whether this association was modified by age at diagnosis, ethnicity, age at menarche or tumor characteristics.</p>
</sec>
<sec>
<title>Results</title>
<p>We confirmed the association of rs10235235 with breast cancer risk for women of European ancestry but found no evidence that this association differed with age at diagnosis. Heterozygote and homozygote odds ratios (ORs) were OR = 0.98 (95% CI 0.94, 1.01;
<italic>P</italic>
= 0.2) and OR = 0.80 (95% CI 0.69, 0.93;
<italic>P</italic>
= 0.004), respectively (
<italic>P</italic>
<sub>trend</sub>
= 0.02). There was no evidence of effect modification by tumor characteristics. rs10235235 was, however, associated with age at menarche in controls (
<italic>P</italic>
<sub>trend</sub>
= 0.005) but not cases (
<italic>P</italic>
<sub>trend</sub>
= 0.97). Consequently the association between rs10235235 and breast cancer risk differed according to age at menarche (
<italic>P</italic>
<sub>het</sub>
= 0.02); the rare allele of rs10235235 was associated with a reduction in breast cancer risk for women who had their menarche age ≥15 years (OR
<sub>het</sub>
= 0.84, 95% CI 0.75, 0.94; OR
<sub>hom</sub>
= 0.81, 95% CI 0.51, 1.30;
<italic>P</italic>
<sub>trend</sub>
= 0.002) but not for those who had their menarche age ≤11 years (OR
<sub>het</sub>
= 1.06, 95% CI 0.95, 1.19, OR
<sub>hom</sub>
= 1.07, 95% CI 0.67, 1.72;
<italic>P</italic>
<sub>trend</sub>
= 0.29).</p>
</sec>
<sec>
<title>Conclusions</title>
<p>To our knowledge rs10235235 is the first single nucleotide polymorphism to be associated with both breast cancer risk and age at menarche consistent with the well-documented association between later age at menarche and a reduction in breast cancer risk. These associations are likely mediated via an effect on circulating hormone levels.</p>
</sec>
</abstract>
</article-meta>
</front>
</pmc>
<affiliations>
<list>
<country>
<li>Allemagne</li>
<li>Australie</li>
<li>Danemark</li>
<li>Espagne</li>
<li>France</li>
<li>Irlande (pays)</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region>
<li>Angleterre</li>
<li>Bade-Wurtemberg</li>
<li>Bavière</li>
<li>Californie</li>
<li>Communauté de Madrid</li>
<li>District de Cologne</li>
<li>District de Haute-Bavière</li>
<li>District de Karlsruhe</li>
<li>District de Moyenne-Franconie</li>
<li>District de Stuttgart</li>
<li>District de Tübingen</li>
<li>Gueldre</li>
<li>Hollande-Septentrionale</li>
<li>Hovedstaden</li>
<li>Oxfordshire</li>
<li>Rhénanie-du-Nord-Westphalie</li>
<li>Victoria (État)</li>
<li>Île-de-France</li>
</region>
<settlement>
<li>Amsterdam</li>
<li>Bonn</li>
<li>Cologne</li>
<li>Copenhague</li>
<li>Erlangen</li>
<li>Heidelberg</li>
<li>Madrid</li>
<li>Melbourne</li>
<li>Munich</li>
<li>Nimègue</li>
<li>Oxford</li>
<li>Paris</li>
<li>Stuttgart</li>
<li>Tübingen</li>
</settlement>
<orgName>
<li>Université d'Oxford</li>
<li>Université de Melbourne</li>
</orgName>
</list>
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<name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name>
</noRegion>
<name sortKey="Dudbridge, Frank" sort="Dudbridge, Frank" uniqKey="Dudbridge F" first="Frank" last="Dudbridge">Frank Dudbridge</name>
<name sortKey="Folkerd, Elizabeth J" sort="Folkerd, Elizabeth J" uniqKey="Folkerd E" first="Elizabeth J" last="Folkerd">Elizabeth J. Folkerd</name>
<name sortKey="Gibson, Lorna" sort="Gibson, Lorna" uniqKey="Gibson L" first="Lorna" last="Gibson">Lorna Gibson</name>
<name sortKey="Haynes, Ben P" sort="Haynes, Ben P" uniqKey="Haynes B" first="Ben P" last="Haynes">Ben P. Haynes</name>
<name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name>
<name sortKey="Jones, Michael E" sort="Jones, Michael E" uniqKey="Jones M" first="Michael E" last="Jones">Michael E. Jones</name>
<name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name>
<name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name>
<name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name>
<name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name>
<name sortKey="Sawyer, Elinor" sort="Sawyer, Elinor" uniqKey="Sawyer E" first="Elinor" last="Sawyer">Elinor Sawyer</name>
<name sortKey="Schoemaker, Minouk J" sort="Schoemaker, Minouk J" uniqKey="Schoemaker M" first="Minouk J" last="Schoemaker">Minouk J. Schoemaker</name>
<name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name>
<name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name>
</country>
<country name="Australie">
<region name="Victoria (État)">
<name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name>
</region>
<name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name>
<name sortKey="Dite, Gillian S" sort="Dite, Gillian S" uniqKey="Dite G" first="Gillian S" last="Dite">Gillian S. Dite</name>
<name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name>
</country>
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<region name="Hollande-Septentrionale">
<name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K" last="Schmidt">Marjanka K. Schmidt</name>
</region>
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<name sortKey="Van Veer, Laura J" sort="Van Veer, Laura J" uniqKey="Van Veer L" first="Laura J" last="Van Veer">Laura J. Van Veer</name>
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<name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W" last="Beckmann">Matthias W. Beckmann</name>
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<name sortKey="Dieffenbach, Aida Karina" sort="Dieffenbach, Aida Karina" uniqKey="Dieffenbach A" first="Aida Karina" last="Dieffenbach">Aida Karina Dieffenbach</name>
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<name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B" last="Ekici">Arif B. Ekici</name>
<name sortKey="Heil, Joerg" sort="Heil, Joerg" uniqKey="Heil J" first="Joerg" last="Heil">Joerg Heil</name>
<name sortKey="Justenhoven, Christina" sort="Justenhoven, Christina" uniqKey="Justenhoven C" first="Christina" last="Justenhoven">Christina Justenhoven</name>
<name sortKey="Justenhoven, Christina" sort="Justenhoven, Christina" uniqKey="Justenhoven C" first="Christina" last="Justenhoven">Christina Justenhoven</name>
<name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name>
<name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name>
<name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name>
<name sortKey="Muller, Heiko" sort="Muller, Heiko" uniqKey="Muller H" first="Heiko" last="Müller">Heiko Müller</name>
<name sortKey="Renner, Stefan P" sort="Renner, Stefan P" uniqKey="Renner S" first="Stefan P" last="Renner">Stefan P. Renner</name>
<name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K" last="Schmutzler">Rita K. Schmutzler</name>
<name sortKey="Schneeweiss, Andreas" sort="Schneeweiss, Andreas" uniqKey="Schneeweiss A" first="Andreas" last="Schneeweiss">Andreas Schneeweiss</name>
<name sortKey="Sohn, Christof" sort="Sohn, Christof" uniqKey="Sohn C" first="Christof" last="Sohn">Christof Sohn</name>
<name sortKey="Sohn, Christof" sort="Sohn, Christof" uniqKey="Sohn C" first="Christof" last="Sohn">Christof Sohn</name>
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<country name="États-Unis">
<region name="Californie">
<name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A" last="Fasching">Peter A. Fasching</name>
</region>
<name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name>
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<name sortKey="Clarke Dur, Christina" sort="Clarke Dur, Christina" uniqKey="Clarke Dur C" first="Christina" last="Clarke Dur">Christina Clarke Dur</name>
<name sortKey="Ziogas, Argyrios" sort="Ziogas, Argyrios" uniqKey="Ziogas A" first="Argyrios" last="Ziogas">Argyrios Ziogas</name>
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<name sortKey="Kerin, Michael" sort="Kerin, Michael" uniqKey="Kerin M" first="Michael" last="Kerin">Michael Kerin</name>
</noRegion>
<name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name>
</country>
<country name="France">
<region name="Île-de-France">
<name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name>
</region>
<name sortKey="Cordina, Emilie" sort="Cordina, Emilie" uniqKey="Cordina E" first="Emilie" last="Cordina">Emilie Cordina</name>
<name sortKey="Cordina, Emilie" sort="Cordina, Emilie" uniqKey="Cordina E" first="Emilie" last="Cordina">Emilie Cordina</name>
<name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name>
<name sortKey="Menegaux, Florence" sort="Menegaux, Florence" uniqKey="Menegaux F" first="Florence" last="Menegaux">Florence Menegaux</name>
<name sortKey="Menegaux, Florence" sort="Menegaux, Florence" uniqKey="Menegaux F" first="Florence" last="Menegaux">Florence Menegaux</name>
<name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Therese" last="Truong">Therese Truong</name>
<name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Therese" last="Truong">Therese Truong</name>
</country>
<country name="Danemark">
<region name="Hovedstaden">
<name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E" last="Bojesen">Stig E. Bojesen</name>
</region>
<name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E" last="Bojesen">Stig E. Bojesen</name>
<name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name>
<name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G" last="Nordestgaard">B Rge G. Nordestgaard</name>
<name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G" last="Nordestgaard">B Rge G. Nordestgaard</name>
</country>
<country name="Espagne">
<region name="Communauté de Madrid">
<name sortKey="Milne, Roger" sort="Milne, Roger" uniqKey="Milne R" first="Roger" last="Milne">Roger Milne</name>
</region>
<name sortKey="Arias Perez, Jose Ignacio" sort="Arias Perez, Jose Ignacio" uniqKey="Arias Perez J" first="Jose Ignacio" last="Arias Perez">Jose Ignacio Arias Perez</name>
<name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name>
<name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name>
<name sortKey="Zamora, M Pilar" sort="Zamora, M Pilar" uniqKey="Zamora M" first="M Pilar" last="Zamora">M Pilar Zamora</name>
</country>
</tree>
</affiliations>
</record>

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