Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles
Identifieur interne : 001459 ( Pmc/Checkpoint ); précédent : 001458; suivant : 001460Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles
Auteurs : Jan Lötvall [Suède] ; Andrew F. Hill [Australie] ; Fred Hochberg [États-Unis] ; Edit I. Buzás [Hongrie] ; Dolores Di Vizio [États-Unis] ; Christopher Gardiner [Royaume-Uni] ; Yong Song Gho [Corée du Sud] ; Igor V. Kurochkin [Singapour] ; Suresh Mathivanan [Australie] ; Peter Quesenberry [États-Unis] ; Susmita Sahoo [États-Unis] ; Hidetoshi Tahara [Japon] ; Marca H. Wauben [Pays-Bas] ; Kenneth W. Witwer [États-Unis] ; Clotilde Théry [France]Source :
- Journal of Extracellular Vesicles [ 2001-3078 ] ; 2014.
Abstract
Secreted membrane-enclosed vesicles, collectively called extracellular vesicles (EVs), which include exosomes, ectosomes, microvesicles, microparticles, apoptotic bodies and other EV subsets, encompass a very rapidly growing scientific field in biology and medicine. Importantly, it is currently technically challenging to obtain a totally pure EV fraction free from non-vesicular components for functional studies, and therefore there is a need to establish guidelines for analyses of these vesicles and reporting of scientific studies on EV biology. Here, the International Society for Extracellular Vesicles (ISEV) provides researchers with a minimal set of biochemical, biophysical and functional standards that should be used to attribute any specific biological cargo or functions to EVs.
Url:
DOI: 10.3402/jev.v3.26913
PubMed: 25536934
PubMed Central: 4275645
Affiliations:
- Australie, Corée du Sud, France, Hongrie, Japon, Pays-Bas, Royaume-Uni, Singapour, Suède, États-Unis
- Angleterre, Californie, Hongrie centrale, Maryland, Oxfordshire, Rhode Island, Utrecht (province), Victoria (État), État de New York, Île-de-France
- Budapest, Melbourne, Oxford, Paris, Utrecht
- Université d'Oxford, Université d'Utrecht, Université de Melbourne
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PMC:4275645Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Secreted membrane-enclosed vesicles, collectively called extracellular vesicles (EVs), which include exosomes, ectosomes, microvesicles, microparticles, apoptotic bodies and other EV subsets, encompass a very rapidly growing scientific field in biology and medicine. Importantly, it is currently technically challenging to obtain a totally pure EV fraction free from non-vesicular components for functional studies, and therefore there is a need to establish guidelines for analyses of these vesicles and reporting of scientific studies on EV biology. Here, the International Society for Extracellular Vesicles (ISEV) provides researchers with a minimal set of biochemical, biophysical and functional standards that should be used to attribute any specific biological cargo or functions to EVs.</p>
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<pmc article-type="editorial"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Extracell Vesicles</journal-id>
<journal-id journal-id-type="iso-abbrev">J Extracell Vesicles</journal-id>
<journal-id journal-id-type="publisher-id">JEV</journal-id>
<journal-title-group><journal-title>Journal of Extracellular Vesicles</journal-title>
</journal-title-group>
<issn pub-type="epub">2001-3078</issn>
<publisher><publisher-name>Co-Action Publishing</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25536934</article-id>
<article-id pub-id-type="pmc">4275645</article-id>
<article-id pub-id-type="publisher-id">26913</article-id>
<article-id pub-id-type="doi">10.3402/jev.v3.26913</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Editorial</subject>
</subj-group>
</article-categories>
<title-group><article-title>Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Lötvall</surname>
<given-names>Jan</given-names>
</name>
<xref ref-type="aff" rid="AF0001">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hill</surname>
<given-names>Andrew F.</given-names>
</name>
<xref ref-type="aff" rid="AF0002">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hochberg</surname>
<given-names>Fred</given-names>
</name>
<xref ref-type="aff" rid="AF0003">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Buzás</surname>
<given-names>Edit I.</given-names>
</name>
<xref ref-type="aff" rid="AF0004">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Di Vizio</surname>
<given-names>Dolores</given-names>
</name>
<xref ref-type="aff" rid="AF0005">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gardiner</surname>
<given-names>Christopher</given-names>
</name>
<xref ref-type="aff" rid="AF0006">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gho</surname>
<given-names>Yong Song</given-names>
</name>
<xref ref-type="aff" rid="AF0007">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kurochkin</surname>
<given-names>Igor V.</given-names>
</name>
<xref ref-type="aff" rid="AF0008">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mathivanan</surname>
<given-names>Suresh</given-names>
</name>
<xref ref-type="aff" rid="AF0009">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Quesenberry</surname>
<given-names>Peter</given-names>
</name>
<xref ref-type="aff" rid="AF0010">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sahoo</surname>
<given-names>Susmita</given-names>
</name>
<xref ref-type="aff" rid="AF0011">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tahara</surname>
<given-names>Hidetoshi</given-names>
</name>
<xref ref-type="aff" rid="AF0012">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wauben</surname>
<given-names>Marca H.</given-names>
</name>
<xref ref-type="aff" rid="AF0013">13</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Witwer</surname>
<given-names>Kenneth W.</given-names>
</name>
<xref ref-type="aff" rid="AF0014">14</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Théry</surname>
<given-names>Clotilde</given-names>
</name>
<xref ref-type="aff" rid="AF0015">15</xref>
</contrib>
</contrib-group>
<aff id="AF0001"><label>1</label>
Krefting Research Centre, University of Gothenburg, Göteborg, Sweden</aff>
<aff id="AF0002"><label>2</label>
Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Australia</aff>
<aff id="AF0003"><label>3</label>
Department of Neurosurgery, University of California at San Diego, San Diego, CA, USA</aff>
<aff id="AF0004"><label>4</label>
Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary</aff>
<aff id="AF0005"><label>5</label>
Cedars-Sinai Medical Center, Los Angeles, CA, USA</aff>
<aff id="AF0006"><label>6</label>
Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, UK</aff>
<aff id="AF0007"><label>7</label>
Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea</aff>
<aff id="AF0008"><label>8</label>
Bioinformatics Institute, Singapore, Singapore</aff>
<aff id="AF0009"><label>9</label>
Department of Biochemistry, La Trobe University, Melbourne, Australia</aff>
<aff id="AF0010"><label>10</label>
The Warren Alpert Medical School of Brown University, Providence, RI, USA</aff>
<aff id="AF0011"><label>11</label>
Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA</aff>
<aff id="AF0012"><label>12</label>
Department of Cellular and Molecular Biology, Hiroshima University Institute of Biomedical & Health Sciences, Hiroshima, Japan</aff>
<aff id="AF0013"><label>13</label>
Department of Biochemistry and Cell Biology, Faculty of Veterinary medicine, Utrecht University, Utrecht, The Netherlands</aff>
<aff id="AF0014"><label>14</label>
Department of Molecular and Comparative Pathobiology, Johns Hopkins School of Medicine, Baltimore, MD, USA</aff>
<aff id="AF0015"><label>15</label>
INSERM U932, Institut Curie, 26 rue d'Ulm, 75005, Paris, France</aff>
<author-notes><corresp id="cor1">Correspondence to: <email xlink:href="clotilde.thery@curie.fr">clotilde.thery@curie.fr</email>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>22</day>
<month>12</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="collection"><year>2014</year>
</pub-date>
<volume>3</volume>
<elocation-id content-type="doi">10.3402/jev.v3.26913</elocation-id>
<permissions><copyright-statement>© 2014 Jan Lötvall et al.</copyright-statement>
<copyright-year>2014</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-nd/3.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract><p>Secreted membrane-enclosed vesicles, collectively called extracellular vesicles (EVs), which include exosomes, ectosomes, microvesicles, microparticles, apoptotic bodies and other EV subsets, encompass a very rapidly growing scientific field in biology and medicine. Importantly, it is currently technically challenging to obtain a totally pure EV fraction free from non-vesicular components for functional studies, and therefore there is a need to establish guidelines for analyses of these vesicles and reporting of scientific studies on EV biology. Here, the International Society for Extracellular Vesicles (ISEV) provides researchers with a minimal set of biochemical, biophysical and functional standards that should be used to attribute any specific biological cargo or functions to EVs.</p>
</abstract>
<kwd-group><kwd>extracellular vesicles</kwd>
<kwd>microvesicles</kwd>
<kwd>microparticles</kwd>
<kwd>exosomes</kwd>
<kwd>ectosomes</kwd>
<kwd>extracellular RNA</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Australie</li>
<li>Corée du Sud</li>
<li>France</li>
<li>Hongrie</li>
<li>Japon</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>Singapour</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Californie</li>
<li>Hongrie centrale</li>
<li>Maryland</li>
<li>Oxfordshire</li>
<li>Rhode Island</li>
<li>Utrecht (province)</li>
<li>Victoria (État)</li>
<li>État de New York</li>
<li>Île-de-France</li>
</region>
<settlement><li>Budapest</li>
<li>Melbourne</li>
<li>Oxford</li>
<li>Paris</li>
<li>Utrecht</li>
</settlement>
<orgName><li>Université d'Oxford</li>
<li>Université d'Utrecht</li>
<li>Université de Melbourne</li>
</orgName>
</list>
<tree><country name="Suède"><noRegion><name sortKey="Lotvall, Jan" sort="Lotvall, Jan" uniqKey="Lotvall J" first="Jan" last="Lötvall">Jan Lötvall</name>
</noRegion>
</country>
<country name="Australie"><region name="Victoria (État)"><name sortKey="Hill, Andrew F" sort="Hill, Andrew F" uniqKey="Hill A" first="Andrew F." last="Hill">Andrew F. Hill</name>
</region>
<name sortKey="Mathivanan, Suresh" sort="Mathivanan, Suresh" uniqKey="Mathivanan S" first="Suresh" last="Mathivanan">Suresh Mathivanan</name>
</country>
<country name="États-Unis"><region name="Californie"><name sortKey="Hochberg, Fred" sort="Hochberg, Fred" uniqKey="Hochberg F" first="Fred" last="Hochberg">Fred Hochberg</name>
</region>
<name sortKey="Di Vizio, Dolores" sort="Di Vizio, Dolores" uniqKey="Di Vizio D" first="Dolores" last="Di Vizio">Dolores Di Vizio</name>
<name sortKey="Quesenberry, Peter" sort="Quesenberry, Peter" uniqKey="Quesenberry P" first="Peter" last="Quesenberry">Peter Quesenberry</name>
<name sortKey="Sahoo, Susmita" sort="Sahoo, Susmita" uniqKey="Sahoo S" first="Susmita" last="Sahoo">Susmita Sahoo</name>
<name sortKey="Witwer, Kenneth W" sort="Witwer, Kenneth W" uniqKey="Witwer K" first="Kenneth W." last="Witwer">Kenneth W. Witwer</name>
</country>
<country name="Hongrie"><region name="Hongrie centrale"><name sortKey="Buzas, Edit I" sort="Buzas, Edit I" uniqKey="Buzas E" first="Edit I." last="Buzás">Edit I. Buzás</name>
</region>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Gardiner, Christopher" sort="Gardiner, Christopher" uniqKey="Gardiner C" first="Christopher" last="Gardiner">Christopher Gardiner</name>
</region>
</country>
<country name="Corée du Sud"><noRegion><name sortKey="Gho, Yong Song" sort="Gho, Yong Song" uniqKey="Gho Y" first="Yong Song" last="Gho">Yong Song Gho</name>
</noRegion>
</country>
<country name="Singapour"><noRegion><name sortKey="Kurochkin, Igor V" sort="Kurochkin, Igor V" uniqKey="Kurochkin I" first="Igor V." last="Kurochkin">Igor V. Kurochkin</name>
</noRegion>
</country>
<country name="Japon"><noRegion><name sortKey="Tahara, Hidetoshi" sort="Tahara, Hidetoshi" uniqKey="Tahara H" first="Hidetoshi" last="Tahara">Hidetoshi Tahara</name>
</noRegion>
</country>
<country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Wauben, Marca H" sort="Wauben, Marca H" uniqKey="Wauben M" first="Marca H." last="Wauben">Marca H. Wauben</name>
</region>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Thery, Clotilde" sort="Thery, Clotilde" uniqKey="Thery C" first="Clotilde" last="Théry">Clotilde Théry</name>
</region>
</country>
</tree>
</affiliations>
</record>
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