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Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)

Identifieur interne : 000F78 ( Pmc/Checkpoint ); précédent : 000F77; suivant : 000F79

Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)

Auteurs : G. Davies [Royaume-Uni] ; N. Armstrong [Australie] ; J C Bis [États-Unis] ; J. Bressler [États-Unis] ; V. Chouraki [France, États-Unis] ; S. Giddaluru [Norvège] ; E. Hofer [Autriche] ; C A Ibrahim-Verbaas [Pays-Bas] ; M. Kirin [Royaume-Uni] ; J. Lahti [Finlande] ; S J Van Der Lee [Pays-Bas] ; S. Le Hellard [Norvège] ; T. Liu [Allemagne] ; R E Marioni [Royaume-Uni, Australie] ; C. Oldmeadow [Australie] ; I. Postmus [Pays-Bas] ; A V Smith [Islande] ; J A Smith [États-Unis] ; A. Thalamuthu [Australie] ; R. Thomson ; V. Vitart [Royaume-Uni] ; J. Wang [États-Unis] ; L. Yu [États-Unis] ; L. Zgaga [Irlande (pays), Croatie] ; W. Zhao [États-Unis] ; R. Boxall [Royaume-Uni] ; S E Harris [Royaume-Uni] ; W D Hill [Royaume-Uni] ; D C Liewald [Royaume-Uni] ; M. Luciano [Royaume-Uni] ; H. Adams [Pays-Bas] ; D. Ames [Australie] ; N. Amin [Pays-Bas] ; P. Amouyel [France] ; A A Assareh [Australie] ; R. Au [États-Unis] ; J T Becker [États-Unis] ; A. Beiser [États-Unis] ; C. Berr [France] ; L. Bertram [Allemagne, Royaume-Uni] ; E. Boerwinkle [États-Unis] ; B M Buckley [Irlande (pays)] ; H. Campbell [Royaume-Uni] ; J. Corley [Royaume-Uni] ; P L De Jager [États-Unis] ; C. Dufouil [France] ; J G Eriksson [Finlande] ; T. Espeseth [Norvège] ; J D Faul [États-Unis] ; I. Ford [Royaume-Uni] ; Generation Scotland [Royaume-Uni] ; R F Gottesman [États-Unis] ; M E Griswold [États-Unis] ; V. Gudnason [Islande] ; T B Harris [États-Unis] ; G. Heiss [États-Unis] ; A. Hofman [Pays-Bas] ; E G Holliday [Australie] ; J. Huffman [Royaume-Uni] ; S L R. Kardia [États-Unis] ; N. Kochan [Australie] ; D S Knopman [États-Unis] ; J B Kwok [Australie] ; J-C Lambert [France] ; T. Lee [Australie] ; G. Li [États-Unis] ; S-C Li [Allemagne] ; M. Loitfelder [Autriche] ; O L Lopez [États-Unis] ; A J Lundervold [Norvège] ; A. Lundqvist [Suède] ; K A Mather [Australie] ; S S Mirza [Pays-Bas] ; L. Nyberg [Suède] ; B A Oostra [Pays-Bas] ; A. Palotie [Royaume-Uni, Finlande] ; G. Papenberg [Allemagne, Suède] ; A. Pattie [Royaume-Uni] ; K. Petrovic [Autriche] ; O. Polasek [Croatie] ; B M Psaty [États-Unis] ; P. Redmond [Royaume-Uni] ; S. Reppermund [Australie] ; J I Rotter [États-Unis] ; H. Schmidt [Autriche] ; M. Schuur [Pays-Bas] ; P W Schofield [Australie] ; R J Scott [Australie] ; V M Steen [Norvège] ; D J Stott [Royaume-Uni] ; J C Van Swieten [Pays-Bas] ; K D Taylor [États-Unis] ; J. Trollor [Australie] ; S. Trompet [Pays-Bas] ; A G Uitterlinden [Pays-Bas] ; G. Weinstein [États-Unis] ; E. Widen [Finlande] ; B G Windham [États-Unis] ; J W Jukema [Pays-Bas] ; A F Wright [Royaume-Uni] ; M J Wright [Australie] ; Q. Yang [États-Unis] ; H. Amieva [France] ; J R Attia [Australie] ; D A Bennett [États-Unis] ; H. Brodaty [Australie] ; A J M. De Craen [Pays-Bas] ; C. Hayward [Royaume-Uni] ; M A Ikram [Pays-Bas] ; U. Lindenberger [Allemagne] ; L-G Nilsson [Suède] ; D J Porteous [Royaume-Uni] ; K. R Ikkönen [Finlande] ; I. Reinvang [Norvège] ; I. Rudan [Royaume-Uni] ; P S Sachdev [Australie] ; R. Schmidt [Autriche] ; P R Schofield [Australie] ; V. Srikanth [Australie] ; J M Starr [Royaume-Uni] ; S T Turner [États-Unis] ; D R Weir [États-Unis] ; J F Wilson [Royaume-Uni] ; C. Van Duijn [Pays-Bas] ; L. Launer [États-Unis] ; A L Fitzpatrick [États-Unis] ; S. Seshadri [États-Unis] ; T H Mosley [États-Unis] ; I J Deary [Royaume-Uni]

Source :

RBID : PMC:4356746

Abstract

General cognitive function is substantially heritable across the human life course from adolescence to old age. We investigated the genetic contribution to variation in this important, health- and well-being-related trait in middle-aged and older adults. We conducted a meta-analysis of genome-wide association studies of 31 cohorts (N=53 949) in which the participants had undertaken multiple, diverse cognitive tests. A general cognitive function phenotype was tested for, and created in each cohort by principal component analysis. We report 13 genome-wide significant single-nucleotide polymorphism (SNP) associations in three genomic regions, 6q16.1, 14q12 and 19q13.32 (best SNP and closest gene, respectively: rs10457441, P=3.93 × 10−9, MIR2113; rs17522122, P=2.55 × 10−8, AKAP6; rs10119, P=5.67 × 10−9, APOE/TOMM40). We report one gene-based significant association with the HMGN1 gene located on chromosome 21 (P=1 × 10−6). These genes have previously been associated with neuropsychiatric phenotypes. Meta-analysis results are consistent with a polygenic model of inheritance. To estimate SNP-based heritability, the genome-wide complex trait analysis procedure was applied to two large cohorts, the Atherosclerosis Risk in Communities Study (N=6617) and the Health and Retirement Study (N=5976). The proportion of phenotypic variation accounted for by all genotyped common SNPs was 29% (s.e.=5%) and 28% (s.e.=7%), respectively. Using polygenic prediction analysis, ~1.2% of the variance in general cognitive function was predicted in the Generation Scotland cohort (N=5487; P=1.5 × 10−17). In hypothesis-driven tests, there was significant association between general cognitive function and four genes previously associated with Alzheimer's disease: TOMM40, APOE, ABCG1 and MEF2C.


Url:
DOI: 10.1038/mp.2014.188
PubMed: 25644384
PubMed Central: 4356746


Affiliations:

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PMC:4356746

Le document en format XML

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<country xml:lang="fr">Norvège</country>
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<country xml:lang="fr">Norvège</country>
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<author>
<name sortKey="Hofer, E" sort="Hofer, E" uniqKey="Hofer E" first="E" last="Hofer">E. Hofer</name>
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<nlm:aff id="aff10">
<institution>Department of Neurology, Medical University of Graz</institution>
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<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<institution>Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz</institution>
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<name sortKey="Ibrahim Verbaas, C A" sort="Ibrahim Verbaas, C A" uniqKey="Ibrahim Verbaas C" first="C A" last="Ibrahim-Verbaas">C A Ibrahim-Verbaas</name>
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<institution>Department of Neurology, Erasmus University Medical Center</institution>
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</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
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</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author>
<name sortKey="Kirin, M" sort="Kirin, M" uniqKey="Kirin M" first="M" last="Kirin">M. Kirin</name>
<affiliation wicri:level="1">
<nlm:aff id="aff14">
<institution>Centre for Population Health Sciences, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author>
<name sortKey="Lahti, J" sort="Lahti, J" uniqKey="Lahti J" first="J" last="Lahti">J. Lahti</name>
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<institution>Institute of Behavioural Sciences, University of Helsinki</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<nlm:aff id="aff16">
<institution>Folkhälsan Research Centre</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<name sortKey="Van Der Lee, S J" sort="Van Der Lee, S J" uniqKey="Van Der Lee S" first="S J" last="Van Der Lee">S J Van Der Lee</name>
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, Rotterdam,
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<name sortKey="Le Hellard, S" sort="Le Hellard, S" uniqKey="Le Hellard S" first="S" last="Le Hellard">S. Le Hellard</name>
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<institution>K.G. Jebsen Centre for Psychosis Research and the Norwegian Centre for Mental Disorders Research (NORMENT), Department of Clinical Science, University of Bergen</institution>
, Bergen,
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</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<institution>Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital</institution>
, Bergen,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author>
<name sortKey="Liu, T" sort="Liu, T" uniqKey="Liu T" first="T" last="Liu">T. Liu</name>
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<nlm:aff id="aff17">
<institution>Max Planck Institute for Human Development</institution>
, Berlin,
<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff18">
<institution>Max Planck Institute for Molecular Genetics</institution>
, Berlin,
<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Marioni, R E" sort="Marioni, R E" uniqKey="Marioni R" first="R E" last="Marioni">R E Marioni</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff19">
<institution>Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff20">
<institution>Queensland Brain Institute, The University of Queensland</institution>
, Brisbane, QLD,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Oldmeadow, C" sort="Oldmeadow, C" uniqKey="Oldmeadow C" first="C" last="Oldmeadow">C. Oldmeadow</name>
<affiliation wicri:level="1">
<nlm:aff id="aff21">
<institution>Hunter Medical Research Institute and Faculty of Health, University of Newcastle</institution>
, Newcastle, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Postmus, I" sort="Postmus, I" uniqKey="Postmus I" first="I" last="Postmus">I. Postmus</name>
<affiliation wicri:level="1">
<nlm:aff id="aff22">
<institution>Department of Gerontology and Geriatrics, Leiden University Medical Center</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff23">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Smith, A V" sort="Smith, A V" uniqKey="Smith A" first="A V" last="Smith">A V Smith</name>
<affiliation wicri:level="1">
<nlm:aff id="aff24">
<institution>Icelandic Heart Association</institution>
, Kopavogur,
<country>Iceland</country>
</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff25">
<institution>University of Iceland</institution>
, Reykjavik,
<country>Iceland</country>
</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Smith, J A" sort="Smith, J A" uniqKey="Smith J" first="J A" last="Smith">J A Smith</name>
<affiliation wicri:level="1">
<nlm:aff id="aff26">
<institution>Department of Epidemiology, University of Michigan</institution>
, Ann Arbor, MI,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Thalamuthu, A" sort="Thalamuthu, A" uniqKey="Thalamuthu A" first="A" last="Thalamuthu">A. Thalamuthu</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Thomson, R" sort="Thomson, R" uniqKey="Thomson R" first="R" last="Thomson">R. Thomson</name>
<affiliation>
<nlm:aff id="aff28">
<institution>Menzies Research Institute</institution>
, Hobart,
<country>Tasmania</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Tasmania</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Vitart, V" sort="Vitart, V" uniqKey="Vitart V" first="V" last="Vitart">V. Vitart</name>
<affiliation wicri:level="1">
<nlm:aff id="aff29">
<institution>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Wang, J" sort="Wang, J" uniqKey="Wang J" first="J" last="Wang">J. Wang</name>
<affiliation wicri:level="1">
<nlm:aff id="aff30">
<institution>Framingham Heart Study</institution>
, Framingham, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff31">
<institution>Department of Biostatistics, Boston University School of Public Health</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Yu, L" sort="Yu, L" uniqKey="Yu L" first="L" last="Yu">L. Yu</name>
<affiliation wicri:level="1">
<nlm:aff id="aff32">
<institution>Rush Alzheimer's Disease Center, Rush University Medical Center</institution>
, Chicago, IL,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Zgaga, L" sort="Zgaga, L" uniqKey="Zgaga L" first="L" last="Zgaga">L. Zgaga</name>
<affiliation wicri:level="1">
<nlm:aff id="aff33">
<institution>Department of Public Health and Primary Care, Trinity College Dublin</institution>
, Dublin,
<country>Ireland</country>
</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff34">
<institution>Andrija Stampar School of Public Health, Medical School, University of Zagreb</institution>
, Zagreb,
<country>Croatia</country>
</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Zhao, W" sort="Zhao, W" uniqKey="Zhao W" first="W" last="Zhao">W. Zhao</name>
<affiliation wicri:level="1">
<nlm:aff id="aff26">
<institution>Department of Epidemiology, University of Michigan</institution>
, Ann Arbor, MI,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Boxall, R" sort="Boxall, R" uniqKey="Boxall R" first="R" last="Boxall">R. Boxall</name>
<affiliation wicri:level="1">
<nlm:aff id="aff19">
<institution>Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Harris, S E" sort="Harris, S E" uniqKey="Harris S" first="S E" last="Harris">S E Harris</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff19">
<institution>Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hill, W D" sort="Hill, W D" uniqKey="Hill W" first="W D" last="Hill">W D Hill</name>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Department of Psychology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Liewald, D C" sort="Liewald, D C" uniqKey="Liewald D" first="D C" last="Liewald">D C Liewald</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Luciano, M" sort="Luciano, M" uniqKey="Luciano M" first="M" last="Luciano">M. Luciano</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Department of Psychology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Adams, H" sort="Adams, H" uniqKey="Adams H" first="H" last="Adams">H. Adams</name>
<affiliation wicri:level="1">
<nlm:aff id="aff35">
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff36">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ames, D" sort="Ames, D" uniqKey="Ames D" first="D" last="Ames">D. Ames</name>
<affiliation wicri:level="1">
<nlm:aff id="aff37">
<institution>National Ageing Research Institute, Royal Melbourne Hospital</institution>
, Melbourne, VIC,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff38">
<institution>Academic Unit for Psychiatry of Old Age, St George's Hospital, University of Melbourne</institution>
, Kew,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Amin, N" sort="Amin, N" uniqKey="Amin N" first="N" last="Amin">N. Amin</name>
<affiliation wicri:level="1">
<nlm:aff id="aff13">
<institution>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff36">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Amouyel, P" sort="Amouyel, P" uniqKey="Amouyel P" first="P" last="Amouyel">P. Amouyel</name>
<affiliation wicri:level="1">
<nlm:aff id="aff6">
<institution>Inserm-UMR744, Institut Pasteur de Lille, Unité d'Epidémiologie et de Santé Publique</institution>
, Lille,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Assareh, A A" sort="Assareh, A A" uniqKey="Assareh A" first="A A" last="Assareh">A A Assareh</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Au, R" sort="Au, R" uniqKey="Au R" first="R" last="Au">R. Au</name>
<affiliation wicri:level="1">
<nlm:aff id="aff7">
<institution>Department of Neurology, Boston University School of Medicine</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff30">
<institution>Framingham Heart Study</institution>
, Framingham, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Becker, J T" sort="Becker, J T" uniqKey="Becker J" first="J T" last="Becker">J T Becker</name>
<affiliation wicri:level="1">
<nlm:aff id="aff39">
<institution>Department of Neurology, University of Pittsburgh</institution>
, Pittsburgh, PA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff40">
<institution>Department of Psychiatry, University of Pittsburgh</institution>
, Pittsburgh, PA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff41">
<institution>Department of Psychology, University of Pittsburgh</institution>
, Pittsburgh, PA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Beiser, A" sort="Beiser, A" uniqKey="Beiser A" first="A" last="Beiser">A. Beiser</name>
<affiliation wicri:level="1">
<nlm:aff id="aff7">
<institution>Department of Neurology, Boston University School of Medicine</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff30">
<institution>Framingham Heart Study</institution>
, Framingham, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Berr, C" sort="Berr, C" uniqKey="Berr C" first="C" last="Berr">C. Berr</name>
<affiliation wicri:level="1">
<nlm:aff id="aff42">
<institution>Inserm, U106</institution>
, Montpellier,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff43">
<institution>Université Montpellier I</institution>
, Montpellier,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Bertram, L" sort="Bertram, L" uniqKey="Bertram L" first="L" last="Bertram">L. Bertram</name>
<affiliation wicri:level="1">
<nlm:aff id="aff18">
<institution>Max Planck Institute for Molecular Genetics</institution>
, Berlin,
<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff44">
<institution>Faculty of Medicine, School of Public Health, Imperial College</institution>
, London,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Boerwinkle, E" sort="Boerwinkle, E" uniqKey="Boerwinkle E" first="E" last="Boerwinkle">E. Boerwinkle</name>
<affiliation wicri:level="1">
<nlm:aff id="aff5">
<institution>Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston</institution>
, Houston, TX,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff45">
<institution>Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Health Science Center at Houston</institution>
, Houston, TX,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff46">
<institution>Human Genome Sequencing Center, Baylor College of Medicine</institution>
, Houston, TX,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Buckley, B M" sort="Buckley, B M" uniqKey="Buckley B" first="B M" last="Buckley">B M Buckley</name>
<affiliation wicri:level="1">
<nlm:aff id="aff47">
<institution>Department of Pharmacology and Therapeutics, University College Cork</institution>
, Cork,
<country>Ireland</country>
</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Campbell, H" sort="Campbell, H" uniqKey="Campbell H" first="H" last="Campbell">H. Campbell</name>
<affiliation wicri:level="1">
<nlm:aff id="aff14">
<institution>Centre for Population Health Sciences, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Corley, J" sort="Corley, J" uniqKey="Corley J" first="J" last="Corley">J. Corley</name>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Department of Psychology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="De Jager, P L" sort="De Jager, P L" uniqKey="De Jager P" first="P L" last="De Jager">P L De Jager</name>
<affiliation wicri:level="1">
<nlm:aff id="aff48">
<institution>Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff49">
<institution>Harvard Medical School</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff50">
<institution>Program in Medical and Population Genetics, Broad Institute</institution>
, Cambridge, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Dufouil, C" sort="Dufouil, C" uniqKey="Dufouil C" first="C" last="Dufouil">C. Dufouil</name>
<affiliation wicri:level="1">
<nlm:aff id="aff51">
<institution>Inserm U708, Neuroepidemiology</institution>
, Paris,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff52">
<institution>Inserm U897, Université Bordeaux Segalen</institution>
, Bordeaux,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Eriksson, J G" sort="Eriksson, J G" uniqKey="Eriksson J" first="J G" last="Eriksson">J G Eriksson</name>
<affiliation wicri:level="1">
<nlm:aff id="aff16">
<institution>Folkhälsan Research Centre</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff53">
<institution>National Institute for Health and Welfare</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff54">
<institution>Department of General Practice and Primary health Care, University of Helsinki</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff55">
<institution>Unit of General Practice, Helsinki University Central Hospital</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Espeseth, T" sort="Espeseth, T" uniqKey="Espeseth T" first="T" last="Espeseth">T. Espeseth</name>
<affiliation wicri:level="1">
<nlm:aff id="aff56">
<institution>K.G. Jebsen Centre for Psychosis Research, Norwegian Centre For Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo</institution>
, Oslo,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff57">
<institution>Department of Psychology, University of Oslo</institution>
, Oslo,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Faul, J D" sort="Faul, J D" uniqKey="Faul J" first="J D" last="Faul">J D Faul</name>
<affiliation wicri:level="1">
<nlm:aff id="aff58">
<institution>Survey Research Center, Institute for Social Research, University of Michigan</institution>
, Ann Arbor, MI,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ford, I" sort="Ford, I" uniqKey="Ford I" first="I" last="Ford">I. Ford</name>
<affiliation wicri:level="1">
<nlm:aff id="aff59">
<institution>Robertson Center for Biostatistics</institution>
, Glasgow,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Scotland, Generation" sort="Scotland, Generation" uniqKey="Scotland G" first="Generation" last="Scotland">Generation Scotland</name>
<affiliation wicri:level="1">
<nlm:aff id="aff60">
<institution>Generation Scotland, University of Edinburgh Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Gottesman, R F" sort="Gottesman, R F" uniqKey="Gottesman R" first="R F" last="Gottesman">R F Gottesman</name>
<affiliation wicri:level="1">
<nlm:aff id="aff61">
<institution>Department of Neurology, Johns Hopkins University School of Medicine</institution>
, Baltimore, MD,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Griswold, M E" sort="Griswold, M E" uniqKey="Griswold M" first="M E" last="Griswold">M E Griswold</name>
<affiliation wicri:level="1">
<nlm:aff id="aff62">
<institution>Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center</institution>
, Jackson, MS,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Gudnason, V" sort="Gudnason, V" uniqKey="Gudnason V" first="V" last="Gudnason">V. Gudnason</name>
<affiliation wicri:level="1">
<nlm:aff id="aff24">
<institution>Icelandic Heart Association</institution>
, Kopavogur,
<country>Iceland</country>
</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff25">
<institution>University of Iceland</institution>
, Reykjavik,
<country>Iceland</country>
</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Harris, T B" sort="Harris, T B" uniqKey="Harris T" first="T B" last="Harris">T B Harris</name>
<affiliation wicri:level="1">
<nlm:aff id="aff63">
<institution>Intramural Research Program National Institutes on Aging, National Institutes of Health</institution>
, Bethesda, MD,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Heiss, G" sort="Heiss, G" uniqKey="Heiss G" first="G" last="Heiss">G. Heiss</name>
<affiliation wicri:level="1">
<nlm:aff id="aff64">
<institution>Department of Epidemiology, University of North Carolina Gillings School of Global Public Health</institution>
, Chapel Hill, NC,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hofman, A" sort="Hofman, A" uniqKey="Hofman A" first="A" last="Hofman">A. Hofman</name>
<affiliation wicri:level="1">
<nlm:aff id="aff35">
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff36">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Holliday, E G" sort="Holliday, E G" uniqKey="Holliday E" first="E G" last="Holliday">E G Holliday</name>
<affiliation wicri:level="1">
<nlm:aff id="aff21">
<institution>Hunter Medical Research Institute and Faculty of Health, University of Newcastle</institution>
, Newcastle, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Huffman, J" sort="Huffman, J" uniqKey="Huffman J" first="J" last="Huffman">J. Huffman</name>
<affiliation wicri:level="1">
<nlm:aff id="aff29">
<institution>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kardia, S L R" sort="Kardia, S L R" uniqKey="Kardia S" first="S L R" last="Kardia">S L R. Kardia</name>
<affiliation wicri:level="1">
<nlm:aff id="aff26">
<institution>Department of Epidemiology, University of Michigan</institution>
, Ann Arbor, MI,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kochan, N" sort="Kochan, N" uniqKey="Kochan N" first="N" last="Kochan">N. Kochan</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff65">
<institution>Neuropsychiatric Institute, Prince of Wales Hospital</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Knopman, D S" sort="Knopman, D S" uniqKey="Knopman D" first="D S" last="Knopman">D S Knopman</name>
<affiliation wicri:level="1">
<nlm:aff id="aff66">
<institution>Department of Neurology, Mayo Clinic</institution>
, Rochester, MN,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kwok, J B" sort="Kwok, J B" uniqKey="Kwok J" first="J B" last="Kwok">J B Kwok</name>
<affiliation wicri:level="1">
<nlm:aff id="aff67">
<institution>Neuroscience Research Australia</institution>
, Randwick, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff68">
<institution>School of Medical Sciences, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lambert, J C" sort="Lambert, J C" uniqKey="Lambert J" first="J-C" last="Lambert">J-C Lambert</name>
<affiliation wicri:level="1">
<nlm:aff id="aff6">
<institution>Inserm-UMR744, Institut Pasteur de Lille, Unité d'Epidémiologie et de Santé Publique</institution>
, Lille,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lee, T" sort="Lee, T" uniqKey="Lee T" first="T" last="Lee">T. Lee</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff65">
<institution>Neuropsychiatric Institute, Prince of Wales Hospital</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Li, G" sort="Li, G" uniqKey="Li G" first="G" last="Li">G. Li</name>
<affiliation wicri:level="1">
<nlm:aff id="aff4">
<institution>Cardiovascular Health Research Unit, Department of Medicine, University of Washington</institution>
, Seattle, WA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Li, S C" sort="Li, S C" uniqKey="Li S" first="S-C" last="Li">S-C Li</name>
<affiliation wicri:level="1">
<nlm:aff id="aff17">
<institution>Max Planck Institute for Human Development</institution>
, Berlin,
<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff69">
<institution>Technische Universität Dresden</institution>
, Dresden,
<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Loitfelder, M" sort="Loitfelder, M" uniqKey="Loitfelder M" first="M" last="Loitfelder">M. Loitfelder</name>
<affiliation wicri:level="1">
<nlm:aff id="aff10">
<institution>Department of Neurology, Medical University of Graz</institution>
, Graz,
<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lopez, O L" sort="Lopez, O L" uniqKey="Lopez O" first="O L" last="Lopez">O L Lopez</name>
<affiliation wicri:level="1">
<nlm:aff id="aff39">
<institution>Department of Neurology, University of Pittsburgh</institution>
, Pittsburgh, PA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lundervold, A J" sort="Lundervold, A J" uniqKey="Lundervold A" first="A J" last="Lundervold">A J Lundervold</name>
<affiliation wicri:level="1">
<nlm:aff id="aff70">
<institution>Department of Biological and Medical Psychology, University of Bergen</institution>
, Bergen,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff71">
<institution>Kavli Research Centre for Aging and Dementia, Haraldsplass Deaconess Hospital</institution>
, Bergen,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff72">
<institution>K.G. Jebsen Centre for Research on Neuropsychiatric Disorders, University of Bergen</institution>
, Bergen,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lundqvist, A" sort="Lundqvist, A" uniqKey="Lundqvist A" first="A" last="Lundqvist">A. Lundqvist</name>
<affiliation wicri:level="1">
<nlm:aff id="aff73">
<institution>Umeå Center for Functional Brain Imaging (UFBI), Umeå University</institution>
, Umeå,
<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Mather, K A" sort="Mather, K A" uniqKey="Mather K" first="K A" last="Mather">K A Mather</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Mirza, S S" sort="Mirza, S S" uniqKey="Mirza S" first="S S" last="Mirza">S S Mirza</name>
<affiliation wicri:level="1">
<nlm:aff id="aff35">
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff36">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Nyberg, L" sort="Nyberg, L" uniqKey="Nyberg L" first="L" last="Nyberg">L. Nyberg</name>
<affiliation wicri:level="1">
<nlm:aff id="aff73">
<institution>Umeå Center for Functional Brain Imaging (UFBI), Umeå University</institution>
, Umeå,
<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff74">
<institution>Department of Radiation Sciences, Umeå University</institution>
, Umeå,
<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff75">
<institution>Department of Integrative Medical Biology, Umeå University</institution>
, Umeå,
<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Oostra, B A" sort="Oostra, B A" uniqKey="Oostra B" first="B A" last="Oostra">B A Oostra</name>
<affiliation wicri:level="1">
<nlm:aff id="aff13">
<institution>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Palotie, A" sort="Palotie, A" uniqKey="Palotie A" first="A" last="Palotie">A. Palotie</name>
<affiliation wicri:level="1">
<nlm:aff id="aff76">
<institution>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus</institution>
, Cambridge,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff77">
<institution>Institute for Molecular Medicine Finland (FIMM), University of Helsinki</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff78">
<institution>Department of Medical Genetics, University of Helsinki and University Central Hospital</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Papenberg, G" sort="Papenberg, G" uniqKey="Papenberg G" first="G" last="Papenberg">G. Papenberg</name>
<affiliation wicri:level="1">
<nlm:aff id="aff17">
<institution>Max Planck Institute for Human Development</institution>
, Berlin,
<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff79">
<institution>Karolinska Institutet, Aging Research Center, Stockholm University</institution>
, Stockholm,
<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Pattie, A" sort="Pattie, A" uniqKey="Pattie A" first="A" last="Pattie">A. Pattie</name>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Department of Psychology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Petrovic, K" sort="Petrovic, K" uniqKey="Petrovic K" first="K" last="Petrovic">K. Petrovic</name>
<affiliation wicri:level="1">
<nlm:aff id="aff10">
<institution>Department of Neurology, Medical University of Graz</institution>
, Graz,
<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Polasek, O" sort="Polasek, O" uniqKey="Polasek O" first="O" last="Polasek">O. Polasek</name>
<affiliation wicri:level="1">
<nlm:aff id="aff80">
<institution>Faculty of Medicine, Department of Public Health, University of Split</institution>
, Split,
<country>Croatia</country>
</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Psaty, B M" sort="Psaty, B M" uniqKey="Psaty B" first="B M" last="Psaty">B M Psaty</name>
<affiliation wicri:level="1">
<nlm:aff id="aff4">
<institution>Cardiovascular Health Research Unit, Department of Medicine, University of Washington</institution>
, Seattle, WA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff81">
<institution>Deparment of Epidemiology, University of Washington</institution>
, Seattle, WA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff82">
<institution>Deparment of Health Services, University of Washington</institution>
, Seattle, WA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff83">
<institution>Group Health Research Unit, Group Health Cooperative</institution>
, Seattle, WA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Redmond, P" sort="Redmond, P" uniqKey="Redmond P" first="P" last="Redmond">P. Redmond</name>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Department of Psychology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Reppermund, S" sort="Reppermund, S" uniqKey="Reppermund S" first="S" last="Reppermund">S. Reppermund</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Rotter, J I" sort="Rotter, J I" uniqKey="Rotter J" first="J I" last="Rotter">J I Rotter</name>
<affiliation wicri:level="1">
<nlm:aff id="aff84">
<institution>Institute for Translational Genomics and Population Sciences Los Angeles BioMedical Research Institute, Harbor-UCLA Medical Center</institution>
, Los Angeles, CA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff85">
<institution>Division of Genetic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center</institution>
, Los Angeles, CA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schmidt, H" sort="Schmidt, H" uniqKey="Schmidt H" first="H" last="Schmidt">H. Schmidt</name>
<affiliation wicri:level="1">
<nlm:aff id="aff10">
<institution>Department of Neurology, Medical University of Graz</institution>
, Graz,
<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff86">
<institution>Centre for Molecular Medicine, Institute of Molecular Biology and Biochemistry, Medical University of Graz</institution>
, Graz,
<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schuur, M" sort="Schuur, M" uniqKey="Schuur M" first="M" last="Schuur">M. Schuur</name>
<affiliation wicri:level="1">
<nlm:aff id="aff12">
<institution>Department of Neurology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff13">
<institution>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schofield, P W" sort="Schofield, P W" uniqKey="Schofield P" first="P W" last="Schofield">P W Schofield</name>
<affiliation wicri:level="1">
<nlm:aff id="aff87">
<institution>School of Medicine and Public Health, University of Newcastle</institution>
, Newcastle, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Scott, R J" sort="Scott, R J" uniqKey="Scott R" first="R J" last="Scott">R J Scott</name>
<affiliation wicri:level="1">
<nlm:aff id="aff21">
<institution>Hunter Medical Research Institute and Faculty of Health, University of Newcastle</institution>
, Newcastle, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Steen, V M" sort="Steen, V M" uniqKey="Steen V" first="V M" last="Steen">V M Steen</name>
<affiliation wicri:level="1">
<nlm:aff id="aff8">
<institution>K.G. Jebsen Centre for Psychosis Research and the Norwegian Centre for Mental Disorders Research (NORMENT), Department of Clinical Science, University of Bergen</institution>
, Bergen,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff9">
<institution>Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital</institution>
, Bergen,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Stott, D J" sort="Stott, D J" uniqKey="Stott D" first="D J" last="Stott">D J Stott</name>
<affiliation wicri:level="1">
<nlm:aff id="aff88">
<institution>Institute of Cardiovascular and Medical Sciences, University of Glasgow</institution>
, Glasgow,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Van Swieten, J C" sort="Van Swieten, J C" uniqKey="Van Swieten J" first="J C" last="Van Swieten">J C Van Swieten</name>
<affiliation wicri:level="1">
<nlm:aff id="aff12">
<institution>Department of Neurology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Taylor, K D" sort="Taylor, K D" uniqKey="Taylor K" first="K D" last="Taylor">K D Taylor</name>
<affiliation wicri:level="1">
<nlm:aff id="aff84">
<institution>Institute for Translational Genomics and Population Sciences Los Angeles BioMedical Research Institute, Harbor-UCLA Medical Center</institution>
, Los Angeles, CA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff89">
<institution>Department of Pediatrics, Harbor-UCLA Medical Center</institution>
, Los Angeles, CA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Trollor, J" sort="Trollor, J" uniqKey="Trollor J" first="J" last="Trollor">J. Trollor</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff90">
<institution>Department of Developmental Disability Neuropsychiatry, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Trompet, S" sort="Trompet, S" uniqKey="Trompet S" first="S" last="Trompet">S. Trompet</name>
<affiliation wicri:level="1">
<nlm:aff id="aff22">
<institution>Department of Gerontology and Geriatrics, Leiden University Medical Center</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff91">
<institution>Department of Cardiology, Leiden University Medical Center</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Uitterlinden, A G" sort="Uitterlinden, A G" uniqKey="Uitterlinden A" first="A G" last="Uitterlinden">A G Uitterlinden</name>
<affiliation wicri:level="1">
<nlm:aff id="aff35">
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff36">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff92">
<institution>Department of Internal Medicine, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Weinstein, G" sort="Weinstein, G" uniqKey="Weinstein G" first="G" last="Weinstein">G. Weinstein</name>
<affiliation wicri:level="1">
<nlm:aff id="aff7">
<institution>Department of Neurology, Boston University School of Medicine</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff30">
<institution>Framingham Heart Study</institution>
, Framingham, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Widen, E" sort="Widen, E" uniqKey="Widen E" first="E" last="Widen">E. Widen</name>
<affiliation wicri:level="1">
<nlm:aff id="aff77">
<institution>Institute for Molecular Medicine Finland (FIMM), University of Helsinki</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Windham, B G" sort="Windham, B G" uniqKey="Windham B" first="B G" last="Windham">B G Windham</name>
<affiliation wicri:level="1">
<nlm:aff id="aff93">
<institution>Division of Geriatrics, Department of Medicine, University of Mississippi Medical Center</institution>
, Jackson, MS,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Jukema, J W" sort="Jukema, J W" uniqKey="Jukema J" first="J W" last="Jukema">J W Jukema</name>
<affiliation wicri:level="1">
<nlm:aff id="aff91">
<institution>Department of Cardiology, Leiden University Medical Center</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff94">
<institution>Durrer Center for Cardiogenetic Research</institution>
, Amsterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff95">
<institution>Interuniversity Cardiology Institute of the Netherlands</institution>
, Utrecht,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Wright, A F" sort="Wright, A F" uniqKey="Wright A" first="A F" last="Wright">A F Wright</name>
<affiliation wicri:level="1">
<nlm:aff id="aff29">
<institution>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Wright, M J" sort="Wright, M J" uniqKey="Wright M" first="M J" last="Wright">M J Wright</name>
<affiliation wicri:level="1">
<nlm:aff id="aff96">
<institution>Neuroimaging Genetics Group, QIMR Berghofer Medical Research Institute</institution>
, Brisbane, QLD,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Yang, Q" sort="Yang, Q" uniqKey="Yang Q" first="Q" last="Yang">Q. Yang</name>
<affiliation wicri:level="1">
<nlm:aff id="aff30">
<institution>Framingham Heart Study</institution>
, Framingham, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff31">
<institution>Department of Biostatistics, Boston University School of Public Health</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Amieva, H" sort="Amieva, H" uniqKey="Amieva H" first="H" last="Amieva">H. Amieva</name>
<affiliation wicri:level="1">
<nlm:aff id="aff52">
<institution>Inserm U897, Université Bordeaux Segalen</institution>
, Bordeaux,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Attia, J R" sort="Attia, J R" uniqKey="Attia J" first="J R" last="Attia">J R Attia</name>
<affiliation wicri:level="1">
<nlm:aff id="aff21">
<institution>Hunter Medical Research Institute and Faculty of Health, University of Newcastle</institution>
, Newcastle, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Bennett, D A" sort="Bennett, D A" uniqKey="Bennett D" first="D A" last="Bennett">D A Bennett</name>
<affiliation wicri:level="1">
<nlm:aff id="aff32">
<institution>Rush Alzheimer's Disease Center, Rush University Medical Center</institution>
, Chicago, IL,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Brodaty, H" sort="Brodaty, H" uniqKey="Brodaty H" first="H" last="Brodaty">H. Brodaty</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff97">
<institution>Dementia Collaborative Research Centre, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="De Craen, A J M" sort="De Craen, A J M" uniqKey="De Craen A" first="A J M" last="De Craen">A J M. De Craen</name>
<affiliation wicri:level="1">
<nlm:aff id="aff22">
<institution>Department of Gerontology and Geriatrics, Leiden University Medical Center</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff23">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hayward, C" sort="Hayward, C" uniqKey="Hayward C" first="C" last="Hayward">C. Hayward</name>
<affiliation wicri:level="1">
<nlm:aff id="aff29">
<institution>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ikram, M A" sort="Ikram, M A" uniqKey="Ikram M" first="M A" last="Ikram">M A Ikram</name>
<affiliation wicri:level="1">
<nlm:aff id="aff12">
<institution>Department of Neurology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff35">
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff36">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff98">
<institution>Department of Radiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lindenberger, U" sort="Lindenberger, U" uniqKey="Lindenberger U" first="U" last="Lindenberger">U. Lindenberger</name>
<affiliation wicri:level="1">
<nlm:aff id="aff17">
<institution>Max Planck Institute for Human Development</institution>
, Berlin,
<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Nilsson, L G" sort="Nilsson, L G" uniqKey="Nilsson L" first="L-G" last="Nilsson">L-G Nilsson</name>
<affiliation wicri:level="1">
<nlm:aff id="aff99">
<institution>ARC, Karolinska Institutet, Stockholm and UFBI, Umeå University</institution>
, Umeå,
<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Porteous, D J" sort="Porteous, D J" uniqKey="Porteous D" first="D J" last="Porteous">D J Porteous</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff19">
<institution>Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff60">
<institution>Generation Scotland, University of Edinburgh Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="R Ikkonen, K" sort="R Ikkonen, K" uniqKey="R Ikkonen K" first="K" last="R Ikkönen">K. R Ikkönen</name>
<affiliation wicri:level="1">
<nlm:aff id="aff15">
<institution>Institute of Behavioural Sciences, University of Helsinki</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Reinvang, I" sort="Reinvang, I" uniqKey="Reinvang I" first="I" last="Reinvang">I. Reinvang</name>
<affiliation wicri:level="1">
<nlm:aff id="aff57">
<institution>Department of Psychology, University of Oslo</institution>
, Oslo,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Rudan, I" sort="Rudan, I" uniqKey="Rudan I" first="I" last="Rudan">I. Rudan</name>
<affiliation wicri:level="1">
<nlm:aff id="aff14">
<institution>Centre for Population Health Sciences, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Sachdev, P S" sort="Sachdev, P S" uniqKey="Sachdev P" first="P S" last="Sachdev">P S Sachdev</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff65">
<institution>Neuropsychiatric Institute, Prince of Wales Hospital</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schmidt, R" sort="Schmidt, R" uniqKey="Schmidt R" first="R" last="Schmidt">R. Schmidt</name>
<affiliation wicri:level="1">
<nlm:aff id="aff10">
<institution>Department of Neurology, Medical University of Graz</institution>
, Graz,
<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schofield, P R" sort="Schofield, P R" uniqKey="Schofield P" first="P R" last="Schofield">P R Schofield</name>
<affiliation wicri:level="1">
<nlm:aff id="aff100">
<institution>Neuroscience Research Australia</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff101">
<institution>Faculty of Medicine, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Srikanth, V" sort="Srikanth, V" uniqKey="Srikanth V" first="V" last="Srikanth">V. Srikanth</name>
<affiliation>
<nlm:aff id="aff28">
<institution>Menzies Research Institute</institution>
, Hobart,
<country>Tasmania</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Tasmania</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff102">
<institution>Stroke and Ageing Research, Medicine, Southern Clinical School, Monash University</institution>
, Melbourne, VIC,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Starr, J M" sort="Starr, J M" uniqKey="Starr J" first="J M" last="Starr">J M Starr</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff103">
<institution>Alzheimer Scotland Dementia Research Centre, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Turner, S T" sort="Turner, S T" uniqKey="Turner S" first="S T" last="Turner">S T Turner</name>
<affiliation wicri:level="1">
<nlm:aff id="aff104">
<institution>Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic</institution>
, Rochester, MN,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Weir, D R" sort="Weir, D R" uniqKey="Weir D" first="D R" last="Weir">D R Weir</name>
<affiliation wicri:level="1">
<nlm:aff id="aff58">
<institution>Survey Research Center, Institute for Social Research, University of Michigan</institution>
, Ann Arbor, MI,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Wilson, J F" sort="Wilson, J F" uniqKey="Wilson J" first="J F" last="Wilson">J F Wilson</name>
<affiliation wicri:level="1">
<nlm:aff id="aff14">
<institution>Centre for Population Health Sciences, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Van Duijn, C" sort="Van Duijn, C" uniqKey="Van Duijn C" first="C" last="Van Duijn">C. Van Duijn</name>
<affiliation wicri:level="1">
<nlm:aff id="aff13">
<institution>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff36">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Launer, L" sort="Launer, L" uniqKey="Launer L" first="L" last="Launer">L. Launer</name>
<affiliation wicri:level="1">
<nlm:aff id="aff63">
<institution>Intramural Research Program National Institutes on Aging, National Institutes of Health</institution>
, Bethesda, MD,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Fitzpatrick, A L" sort="Fitzpatrick, A L" uniqKey="Fitzpatrick A" first="A L" last="Fitzpatrick">A L Fitzpatrick</name>
<affiliation wicri:level="1">
<nlm:aff id="aff81">
<institution>Deparment of Epidemiology, University of Washington</institution>
, Seattle, WA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff105">
<institution>Department of Global Health, University of Washington</institution>
, Seattle, WA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Seshadri, S" sort="Seshadri, S" uniqKey="Seshadri S" first="S" last="Seshadri">S. Seshadri</name>
<affiliation wicri:level="1">
<nlm:aff id="aff7">
<institution>Department of Neurology, Boston University School of Medicine</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff30">
<institution>Framingham Heart Study</institution>
, Framingham, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Mosley, T H" sort="Mosley, T H" uniqKey="Mosley T" first="T H" last="Mosley">T H Mosley</name>
<affiliation wicri:level="1">
<nlm:aff id="aff93">
<institution>Division of Geriatrics, Department of Medicine, University of Mississippi Medical Center</institution>
, Jackson, MS,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Deary, I J" sort="Deary, I J" uniqKey="Deary I" first="I J" last="Deary">I J Deary</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Department of Psychology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PMC</idno>
<idno type="pmid">25644384</idno>
<idno type="pmc">4356746</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356746</idno>
<idno type="RBID">PMC:4356746</idno>
<idno type="doi">10.1038/mp.2014.188</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">000031</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000031</idno>
<idno type="wicri:Area/Pmc/Curation">000031</idno>
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<idno type="wicri:Area/Pmc/Checkpoint">000F78</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000F78</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en" level="a" type="main">Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (
<italic>N</italic>
=53 949)</title>
<author>
<name sortKey="Davies, G" sort="Davies, G" uniqKey="Davies G" first="G" last="Davies">G. Davies</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Department of Psychology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Armstrong, N" sort="Armstrong, N" uniqKey="Armstrong N" first="N" last="Armstrong">N. Armstrong</name>
<affiliation wicri:level="1">
<nlm:aff id="aff3">
<institution>School of Mathematics and Statistics, University of Sydney</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Bis, J C" sort="Bis, J C" uniqKey="Bis J" first="J C" last="Bis">J C Bis</name>
<affiliation wicri:level="1">
<nlm:aff id="aff4">
<institution>Cardiovascular Health Research Unit, Department of Medicine, University of Washington</institution>
, Seattle, WA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Bressler, J" sort="Bressler, J" uniqKey="Bressler J" first="J" last="Bressler">J. Bressler</name>
<affiliation wicri:level="1">
<nlm:aff id="aff5">
<institution>Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston</institution>
, Houston, TX,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Chouraki, V" sort="Chouraki, V" uniqKey="Chouraki V" first="V" last="Chouraki">V. Chouraki</name>
<affiliation wicri:level="1">
<nlm:aff id="aff6">
<institution>Inserm-UMR744, Institut Pasteur de Lille, Unité d'Epidémiologie et de Santé Publique</institution>
, Lille,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff7">
<institution>Department of Neurology, Boston University School of Medicine</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Giddaluru, S" sort="Giddaluru, S" uniqKey="Giddaluru S" first="S" last="Giddaluru">S. Giddaluru</name>
<affiliation wicri:level="1">
<nlm:aff id="aff8">
<institution>K.G. Jebsen Centre for Psychosis Research and the Norwegian Centre for Mental Disorders Research (NORMENT), Department of Clinical Science, University of Bergen</institution>
, Bergen,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff9">
<institution>Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital</institution>
, Bergen,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hofer, E" sort="Hofer, E" uniqKey="Hofer E" first="E" last="Hofer">E. Hofer</name>
<affiliation wicri:level="1">
<nlm:aff id="aff10">
<institution>Department of Neurology, Medical University of Graz</institution>
, Graz,
<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff11">
<institution>Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz</institution>
, Graz,
<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ibrahim Verbaas, C A" sort="Ibrahim Verbaas, C A" uniqKey="Ibrahim Verbaas C" first="C A" last="Ibrahim-Verbaas">C A Ibrahim-Verbaas</name>
<affiliation wicri:level="1">
<nlm:aff id="aff12">
<institution>Department of Neurology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff13">
<institution>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kirin, M" sort="Kirin, M" uniqKey="Kirin M" first="M" last="Kirin">M. Kirin</name>
<affiliation wicri:level="1">
<nlm:aff id="aff14">
<institution>Centre for Population Health Sciences, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lahti, J" sort="Lahti, J" uniqKey="Lahti J" first="J" last="Lahti">J. Lahti</name>
<affiliation wicri:level="1">
<nlm:aff id="aff15">
<institution>Institute of Behavioural Sciences, University of Helsinki</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff16">
<institution>Folkhälsan Research Centre</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Van Der Lee, S J" sort="Van Der Lee, S J" uniqKey="Van Der Lee S" first="S J" last="Van Der Lee">S J Van Der Lee</name>
<affiliation wicri:level="1">
<nlm:aff id="aff13">
<institution>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Le Hellard, S" sort="Le Hellard, S" uniqKey="Le Hellard S" first="S" last="Le Hellard">S. Le Hellard</name>
<affiliation wicri:level="1">
<nlm:aff id="aff8">
<institution>K.G. Jebsen Centre for Psychosis Research and the Norwegian Centre for Mental Disorders Research (NORMENT), Department of Clinical Science, University of Bergen</institution>
, Bergen,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff9">
<institution>Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital</institution>
, Bergen,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Liu, T" sort="Liu, T" uniqKey="Liu T" first="T" last="Liu">T. Liu</name>
<affiliation wicri:level="1">
<nlm:aff id="aff17">
<institution>Max Planck Institute for Human Development</institution>
, Berlin,
<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff18">
<institution>Max Planck Institute for Molecular Genetics</institution>
, Berlin,
<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Marioni, R E" sort="Marioni, R E" uniqKey="Marioni R" first="R E" last="Marioni">R E Marioni</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff19">
<institution>Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff20">
<institution>Queensland Brain Institute, The University of Queensland</institution>
, Brisbane, QLD,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Oldmeadow, C" sort="Oldmeadow, C" uniqKey="Oldmeadow C" first="C" last="Oldmeadow">C. Oldmeadow</name>
<affiliation wicri:level="1">
<nlm:aff id="aff21">
<institution>Hunter Medical Research Institute and Faculty of Health, University of Newcastle</institution>
, Newcastle, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Postmus, I" sort="Postmus, I" uniqKey="Postmus I" first="I" last="Postmus">I. Postmus</name>
<affiliation wicri:level="1">
<nlm:aff id="aff22">
<institution>Department of Gerontology and Geriatrics, Leiden University Medical Center</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff23">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Smith, A V" sort="Smith, A V" uniqKey="Smith A" first="A V" last="Smith">A V Smith</name>
<affiliation wicri:level="1">
<nlm:aff id="aff24">
<institution>Icelandic Heart Association</institution>
, Kopavogur,
<country>Iceland</country>
</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff25">
<institution>University of Iceland</institution>
, Reykjavik,
<country>Iceland</country>
</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Smith, J A" sort="Smith, J A" uniqKey="Smith J" first="J A" last="Smith">J A Smith</name>
<affiliation wicri:level="1">
<nlm:aff id="aff26">
<institution>Department of Epidemiology, University of Michigan</institution>
, Ann Arbor, MI,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Thalamuthu, A" sort="Thalamuthu, A" uniqKey="Thalamuthu A" first="A" last="Thalamuthu">A. Thalamuthu</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Thomson, R" sort="Thomson, R" uniqKey="Thomson R" first="R" last="Thomson">R. Thomson</name>
<affiliation>
<nlm:aff id="aff28">
<institution>Menzies Research Institute</institution>
, Hobart,
<country>Tasmania</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Tasmania</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Vitart, V" sort="Vitart, V" uniqKey="Vitart V" first="V" last="Vitart">V. Vitart</name>
<affiliation wicri:level="1">
<nlm:aff id="aff29">
<institution>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Wang, J" sort="Wang, J" uniqKey="Wang J" first="J" last="Wang">J. Wang</name>
<affiliation wicri:level="1">
<nlm:aff id="aff30">
<institution>Framingham Heart Study</institution>
, Framingham, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff31">
<institution>Department of Biostatistics, Boston University School of Public Health</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Yu, L" sort="Yu, L" uniqKey="Yu L" first="L" last="Yu">L. Yu</name>
<affiliation wicri:level="1">
<nlm:aff id="aff32">
<institution>Rush Alzheimer's Disease Center, Rush University Medical Center</institution>
, Chicago, IL,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Zgaga, L" sort="Zgaga, L" uniqKey="Zgaga L" first="L" last="Zgaga">L. Zgaga</name>
<affiliation wicri:level="1">
<nlm:aff id="aff33">
<institution>Department of Public Health and Primary Care, Trinity College Dublin</institution>
, Dublin,
<country>Ireland</country>
</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff34">
<institution>Andrija Stampar School of Public Health, Medical School, University of Zagreb</institution>
, Zagreb,
<country>Croatia</country>
</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Zhao, W" sort="Zhao, W" uniqKey="Zhao W" first="W" last="Zhao">W. Zhao</name>
<affiliation wicri:level="1">
<nlm:aff id="aff26">
<institution>Department of Epidemiology, University of Michigan</institution>
, Ann Arbor, MI,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Boxall, R" sort="Boxall, R" uniqKey="Boxall R" first="R" last="Boxall">R. Boxall</name>
<affiliation wicri:level="1">
<nlm:aff id="aff19">
<institution>Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Harris, S E" sort="Harris, S E" uniqKey="Harris S" first="S E" last="Harris">S E Harris</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff19">
<institution>Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hill, W D" sort="Hill, W D" uniqKey="Hill W" first="W D" last="Hill">W D Hill</name>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Department of Psychology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Liewald, D C" sort="Liewald, D C" uniqKey="Liewald D" first="D C" last="Liewald">D C Liewald</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Luciano, M" sort="Luciano, M" uniqKey="Luciano M" first="M" last="Luciano">M. Luciano</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Department of Psychology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Adams, H" sort="Adams, H" uniqKey="Adams H" first="H" last="Adams">H. Adams</name>
<affiliation wicri:level="1">
<nlm:aff id="aff35">
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff36">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ames, D" sort="Ames, D" uniqKey="Ames D" first="D" last="Ames">D. Ames</name>
<affiliation wicri:level="1">
<nlm:aff id="aff37">
<institution>National Ageing Research Institute, Royal Melbourne Hospital</institution>
, Melbourne, VIC,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff38">
<institution>Academic Unit for Psychiatry of Old Age, St George's Hospital, University of Melbourne</institution>
, Kew,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Amin, N" sort="Amin, N" uniqKey="Amin N" first="N" last="Amin">N. Amin</name>
<affiliation wicri:level="1">
<nlm:aff id="aff13">
<institution>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff36">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Amouyel, P" sort="Amouyel, P" uniqKey="Amouyel P" first="P" last="Amouyel">P. Amouyel</name>
<affiliation wicri:level="1">
<nlm:aff id="aff6">
<institution>Inserm-UMR744, Institut Pasteur de Lille, Unité d'Epidémiologie et de Santé Publique</institution>
, Lille,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Assareh, A A" sort="Assareh, A A" uniqKey="Assareh A" first="A A" last="Assareh">A A Assareh</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Au, R" sort="Au, R" uniqKey="Au R" first="R" last="Au">R. Au</name>
<affiliation wicri:level="1">
<nlm:aff id="aff7">
<institution>Department of Neurology, Boston University School of Medicine</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff30">
<institution>Framingham Heart Study</institution>
, Framingham, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Becker, J T" sort="Becker, J T" uniqKey="Becker J" first="J T" last="Becker">J T Becker</name>
<affiliation wicri:level="1">
<nlm:aff id="aff39">
<institution>Department of Neurology, University of Pittsburgh</institution>
, Pittsburgh, PA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff40">
<institution>Department of Psychiatry, University of Pittsburgh</institution>
, Pittsburgh, PA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff41">
<institution>Department of Psychology, University of Pittsburgh</institution>
, Pittsburgh, PA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Beiser, A" sort="Beiser, A" uniqKey="Beiser A" first="A" last="Beiser">A. Beiser</name>
<affiliation wicri:level="1">
<nlm:aff id="aff7">
<institution>Department of Neurology, Boston University School of Medicine</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff30">
<institution>Framingham Heart Study</institution>
, Framingham, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Berr, C" sort="Berr, C" uniqKey="Berr C" first="C" last="Berr">C. Berr</name>
<affiliation wicri:level="1">
<nlm:aff id="aff42">
<institution>Inserm, U106</institution>
, Montpellier,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff43">
<institution>Université Montpellier I</institution>
, Montpellier,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Bertram, L" sort="Bertram, L" uniqKey="Bertram L" first="L" last="Bertram">L. Bertram</name>
<affiliation wicri:level="1">
<nlm:aff id="aff18">
<institution>Max Planck Institute for Molecular Genetics</institution>
, Berlin,
<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff44">
<institution>Faculty of Medicine, School of Public Health, Imperial College</institution>
, London,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Boerwinkle, E" sort="Boerwinkle, E" uniqKey="Boerwinkle E" first="E" last="Boerwinkle">E. Boerwinkle</name>
<affiliation wicri:level="1">
<nlm:aff id="aff5">
<institution>Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston</institution>
, Houston, TX,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff45">
<institution>Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Health Science Center at Houston</institution>
, Houston, TX,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff46">
<institution>Human Genome Sequencing Center, Baylor College of Medicine</institution>
, Houston, TX,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Buckley, B M" sort="Buckley, B M" uniqKey="Buckley B" first="B M" last="Buckley">B M Buckley</name>
<affiliation wicri:level="1">
<nlm:aff id="aff47">
<institution>Department of Pharmacology and Therapeutics, University College Cork</institution>
, Cork,
<country>Ireland</country>
</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Campbell, H" sort="Campbell, H" uniqKey="Campbell H" first="H" last="Campbell">H. Campbell</name>
<affiliation wicri:level="1">
<nlm:aff id="aff14">
<institution>Centre for Population Health Sciences, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Corley, J" sort="Corley, J" uniqKey="Corley J" first="J" last="Corley">J. Corley</name>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Department of Psychology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="De Jager, P L" sort="De Jager, P L" uniqKey="De Jager P" first="P L" last="De Jager">P L De Jager</name>
<affiliation wicri:level="1">
<nlm:aff id="aff48">
<institution>Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff49">
<institution>Harvard Medical School</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff50">
<institution>Program in Medical and Population Genetics, Broad Institute</institution>
, Cambridge, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Dufouil, C" sort="Dufouil, C" uniqKey="Dufouil C" first="C" last="Dufouil">C. Dufouil</name>
<affiliation wicri:level="1">
<nlm:aff id="aff51">
<institution>Inserm U708, Neuroepidemiology</institution>
, Paris,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff52">
<institution>Inserm U897, Université Bordeaux Segalen</institution>
, Bordeaux,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Eriksson, J G" sort="Eriksson, J G" uniqKey="Eriksson J" first="J G" last="Eriksson">J G Eriksson</name>
<affiliation wicri:level="1">
<nlm:aff id="aff16">
<institution>Folkhälsan Research Centre</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff53">
<institution>National Institute for Health and Welfare</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff54">
<institution>Department of General Practice and Primary health Care, University of Helsinki</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff55">
<institution>Unit of General Practice, Helsinki University Central Hospital</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Espeseth, T" sort="Espeseth, T" uniqKey="Espeseth T" first="T" last="Espeseth">T. Espeseth</name>
<affiliation wicri:level="1">
<nlm:aff id="aff56">
<institution>K.G. Jebsen Centre for Psychosis Research, Norwegian Centre For Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo</institution>
, Oslo,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff57">
<institution>Department of Psychology, University of Oslo</institution>
, Oslo,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Faul, J D" sort="Faul, J D" uniqKey="Faul J" first="J D" last="Faul">J D Faul</name>
<affiliation wicri:level="1">
<nlm:aff id="aff58">
<institution>Survey Research Center, Institute for Social Research, University of Michigan</institution>
, Ann Arbor, MI,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ford, I" sort="Ford, I" uniqKey="Ford I" first="I" last="Ford">I. Ford</name>
<affiliation wicri:level="1">
<nlm:aff id="aff59">
<institution>Robertson Center for Biostatistics</institution>
, Glasgow,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Scotland, Generation" sort="Scotland, Generation" uniqKey="Scotland G" first="Generation" last="Scotland">Generation Scotland</name>
<affiliation wicri:level="1">
<nlm:aff id="aff60">
<institution>Generation Scotland, University of Edinburgh Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Gottesman, R F" sort="Gottesman, R F" uniqKey="Gottesman R" first="R F" last="Gottesman">R F Gottesman</name>
<affiliation wicri:level="1">
<nlm:aff id="aff61">
<institution>Department of Neurology, Johns Hopkins University School of Medicine</institution>
, Baltimore, MD,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Griswold, M E" sort="Griswold, M E" uniqKey="Griswold M" first="M E" last="Griswold">M E Griswold</name>
<affiliation wicri:level="1">
<nlm:aff id="aff62">
<institution>Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center</institution>
, Jackson, MS,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Gudnason, V" sort="Gudnason, V" uniqKey="Gudnason V" first="V" last="Gudnason">V. Gudnason</name>
<affiliation wicri:level="1">
<nlm:aff id="aff24">
<institution>Icelandic Heart Association</institution>
, Kopavogur,
<country>Iceland</country>
</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff25">
<institution>University of Iceland</institution>
, Reykjavik,
<country>Iceland</country>
</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Harris, T B" sort="Harris, T B" uniqKey="Harris T" first="T B" last="Harris">T B Harris</name>
<affiliation wicri:level="1">
<nlm:aff id="aff63">
<institution>Intramural Research Program National Institutes on Aging, National Institutes of Health</institution>
, Bethesda, MD,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Heiss, G" sort="Heiss, G" uniqKey="Heiss G" first="G" last="Heiss">G. Heiss</name>
<affiliation wicri:level="1">
<nlm:aff id="aff64">
<institution>Department of Epidemiology, University of North Carolina Gillings School of Global Public Health</institution>
, Chapel Hill, NC,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hofman, A" sort="Hofman, A" uniqKey="Hofman A" first="A" last="Hofman">A. Hofman</name>
<affiliation wicri:level="1">
<nlm:aff id="aff35">
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff36">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Holliday, E G" sort="Holliday, E G" uniqKey="Holliday E" first="E G" last="Holliday">E G Holliday</name>
<affiliation wicri:level="1">
<nlm:aff id="aff21">
<institution>Hunter Medical Research Institute and Faculty of Health, University of Newcastle</institution>
, Newcastle, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Huffman, J" sort="Huffman, J" uniqKey="Huffman J" first="J" last="Huffman">J. Huffman</name>
<affiliation wicri:level="1">
<nlm:aff id="aff29">
<institution>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kardia, S L R" sort="Kardia, S L R" uniqKey="Kardia S" first="S L R" last="Kardia">S L R. Kardia</name>
<affiliation wicri:level="1">
<nlm:aff id="aff26">
<institution>Department of Epidemiology, University of Michigan</institution>
, Ann Arbor, MI,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kochan, N" sort="Kochan, N" uniqKey="Kochan N" first="N" last="Kochan">N. Kochan</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff65">
<institution>Neuropsychiatric Institute, Prince of Wales Hospital</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Knopman, D S" sort="Knopman, D S" uniqKey="Knopman D" first="D S" last="Knopman">D S Knopman</name>
<affiliation wicri:level="1">
<nlm:aff id="aff66">
<institution>Department of Neurology, Mayo Clinic</institution>
, Rochester, MN,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kwok, J B" sort="Kwok, J B" uniqKey="Kwok J" first="J B" last="Kwok">J B Kwok</name>
<affiliation wicri:level="1">
<nlm:aff id="aff67">
<institution>Neuroscience Research Australia</institution>
, Randwick, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff68">
<institution>School of Medical Sciences, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lambert, J C" sort="Lambert, J C" uniqKey="Lambert J" first="J-C" last="Lambert">J-C Lambert</name>
<affiliation wicri:level="1">
<nlm:aff id="aff6">
<institution>Inserm-UMR744, Institut Pasteur de Lille, Unité d'Epidémiologie et de Santé Publique</institution>
, Lille,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lee, T" sort="Lee, T" uniqKey="Lee T" first="T" last="Lee">T. Lee</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff65">
<institution>Neuropsychiatric Institute, Prince of Wales Hospital</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Li, G" sort="Li, G" uniqKey="Li G" first="G" last="Li">G. Li</name>
<affiliation wicri:level="1">
<nlm:aff id="aff4">
<institution>Cardiovascular Health Research Unit, Department of Medicine, University of Washington</institution>
, Seattle, WA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Li, S C" sort="Li, S C" uniqKey="Li S" first="S-C" last="Li">S-C Li</name>
<affiliation wicri:level="1">
<nlm:aff id="aff17">
<institution>Max Planck Institute for Human Development</institution>
, Berlin,
<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff69">
<institution>Technische Universität Dresden</institution>
, Dresden,
<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Loitfelder, M" sort="Loitfelder, M" uniqKey="Loitfelder M" first="M" last="Loitfelder">M. Loitfelder</name>
<affiliation wicri:level="1">
<nlm:aff id="aff10">
<institution>Department of Neurology, Medical University of Graz</institution>
, Graz,
<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lopez, O L" sort="Lopez, O L" uniqKey="Lopez O" first="O L" last="Lopez">O L Lopez</name>
<affiliation wicri:level="1">
<nlm:aff id="aff39">
<institution>Department of Neurology, University of Pittsburgh</institution>
, Pittsburgh, PA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lundervold, A J" sort="Lundervold, A J" uniqKey="Lundervold A" first="A J" last="Lundervold">A J Lundervold</name>
<affiliation wicri:level="1">
<nlm:aff id="aff70">
<institution>Department of Biological and Medical Psychology, University of Bergen</institution>
, Bergen,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff71">
<institution>Kavli Research Centre for Aging and Dementia, Haraldsplass Deaconess Hospital</institution>
, Bergen,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff72">
<institution>K.G. Jebsen Centre for Research on Neuropsychiatric Disorders, University of Bergen</institution>
, Bergen,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lundqvist, A" sort="Lundqvist, A" uniqKey="Lundqvist A" first="A" last="Lundqvist">A. Lundqvist</name>
<affiliation wicri:level="1">
<nlm:aff id="aff73">
<institution>Umeå Center for Functional Brain Imaging (UFBI), Umeå University</institution>
, Umeå,
<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Mather, K A" sort="Mather, K A" uniqKey="Mather K" first="K A" last="Mather">K A Mather</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Mirza, S S" sort="Mirza, S S" uniqKey="Mirza S" first="S S" last="Mirza">S S Mirza</name>
<affiliation wicri:level="1">
<nlm:aff id="aff35">
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff36">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Nyberg, L" sort="Nyberg, L" uniqKey="Nyberg L" first="L" last="Nyberg">L. Nyberg</name>
<affiliation wicri:level="1">
<nlm:aff id="aff73">
<institution>Umeå Center for Functional Brain Imaging (UFBI), Umeå University</institution>
, Umeå,
<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff74">
<institution>Department of Radiation Sciences, Umeå University</institution>
, Umeå,
<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff75">
<institution>Department of Integrative Medical Biology, Umeå University</institution>
, Umeå,
<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Oostra, B A" sort="Oostra, B A" uniqKey="Oostra B" first="B A" last="Oostra">B A Oostra</name>
<affiliation wicri:level="1">
<nlm:aff id="aff13">
<institution>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Palotie, A" sort="Palotie, A" uniqKey="Palotie A" first="A" last="Palotie">A. Palotie</name>
<affiliation wicri:level="1">
<nlm:aff id="aff76">
<institution>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus</institution>
, Cambridge,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff77">
<institution>Institute for Molecular Medicine Finland (FIMM), University of Helsinki</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff78">
<institution>Department of Medical Genetics, University of Helsinki and University Central Hospital</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Papenberg, G" sort="Papenberg, G" uniqKey="Papenberg G" first="G" last="Papenberg">G. Papenberg</name>
<affiliation wicri:level="1">
<nlm:aff id="aff17">
<institution>Max Planck Institute for Human Development</institution>
, Berlin,
<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff79">
<institution>Karolinska Institutet, Aging Research Center, Stockholm University</institution>
, Stockholm,
<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Pattie, A" sort="Pattie, A" uniqKey="Pattie A" first="A" last="Pattie">A. Pattie</name>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Department of Psychology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Petrovic, K" sort="Petrovic, K" uniqKey="Petrovic K" first="K" last="Petrovic">K. Petrovic</name>
<affiliation wicri:level="1">
<nlm:aff id="aff10">
<institution>Department of Neurology, Medical University of Graz</institution>
, Graz,
<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Polasek, O" sort="Polasek, O" uniqKey="Polasek O" first="O" last="Polasek">O. Polasek</name>
<affiliation wicri:level="1">
<nlm:aff id="aff80">
<institution>Faculty of Medicine, Department of Public Health, University of Split</institution>
, Split,
<country>Croatia</country>
</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Psaty, B M" sort="Psaty, B M" uniqKey="Psaty B" first="B M" last="Psaty">B M Psaty</name>
<affiliation wicri:level="1">
<nlm:aff id="aff4">
<institution>Cardiovascular Health Research Unit, Department of Medicine, University of Washington</institution>
, Seattle, WA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff81">
<institution>Deparment of Epidemiology, University of Washington</institution>
, Seattle, WA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff82">
<institution>Deparment of Health Services, University of Washington</institution>
, Seattle, WA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff83">
<institution>Group Health Research Unit, Group Health Cooperative</institution>
, Seattle, WA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Redmond, P" sort="Redmond, P" uniqKey="Redmond P" first="P" last="Redmond">P. Redmond</name>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Department of Psychology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Reppermund, S" sort="Reppermund, S" uniqKey="Reppermund S" first="S" last="Reppermund">S. Reppermund</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Rotter, J I" sort="Rotter, J I" uniqKey="Rotter J" first="J I" last="Rotter">J I Rotter</name>
<affiliation wicri:level="1">
<nlm:aff id="aff84">
<institution>Institute for Translational Genomics and Population Sciences Los Angeles BioMedical Research Institute, Harbor-UCLA Medical Center</institution>
, Los Angeles, CA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff85">
<institution>Division of Genetic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center</institution>
, Los Angeles, CA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schmidt, H" sort="Schmidt, H" uniqKey="Schmidt H" first="H" last="Schmidt">H. Schmidt</name>
<affiliation wicri:level="1">
<nlm:aff id="aff10">
<institution>Department of Neurology, Medical University of Graz</institution>
, Graz,
<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff86">
<institution>Centre for Molecular Medicine, Institute of Molecular Biology and Biochemistry, Medical University of Graz</institution>
, Graz,
<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schuur, M" sort="Schuur, M" uniqKey="Schuur M" first="M" last="Schuur">M. Schuur</name>
<affiliation wicri:level="1">
<nlm:aff id="aff12">
<institution>Department of Neurology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff13">
<institution>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schofield, P W" sort="Schofield, P W" uniqKey="Schofield P" first="P W" last="Schofield">P W Schofield</name>
<affiliation wicri:level="1">
<nlm:aff id="aff87">
<institution>School of Medicine and Public Health, University of Newcastle</institution>
, Newcastle, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Scott, R J" sort="Scott, R J" uniqKey="Scott R" first="R J" last="Scott">R J Scott</name>
<affiliation wicri:level="1">
<nlm:aff id="aff21">
<institution>Hunter Medical Research Institute and Faculty of Health, University of Newcastle</institution>
, Newcastle, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Steen, V M" sort="Steen, V M" uniqKey="Steen V" first="V M" last="Steen">V M Steen</name>
<affiliation wicri:level="1">
<nlm:aff id="aff8">
<institution>K.G. Jebsen Centre for Psychosis Research and the Norwegian Centre for Mental Disorders Research (NORMENT), Department of Clinical Science, University of Bergen</institution>
, Bergen,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff9">
<institution>Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital</institution>
, Bergen,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Stott, D J" sort="Stott, D J" uniqKey="Stott D" first="D J" last="Stott">D J Stott</name>
<affiliation wicri:level="1">
<nlm:aff id="aff88">
<institution>Institute of Cardiovascular and Medical Sciences, University of Glasgow</institution>
, Glasgow,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Van Swieten, J C" sort="Van Swieten, J C" uniqKey="Van Swieten J" first="J C" last="Van Swieten">J C Van Swieten</name>
<affiliation wicri:level="1">
<nlm:aff id="aff12">
<institution>Department of Neurology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Taylor, K D" sort="Taylor, K D" uniqKey="Taylor K" first="K D" last="Taylor">K D Taylor</name>
<affiliation wicri:level="1">
<nlm:aff id="aff84">
<institution>Institute for Translational Genomics and Population Sciences Los Angeles BioMedical Research Institute, Harbor-UCLA Medical Center</institution>
, Los Angeles, CA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff89">
<institution>Department of Pediatrics, Harbor-UCLA Medical Center</institution>
, Los Angeles, CA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Trollor, J" sort="Trollor, J" uniqKey="Trollor J" first="J" last="Trollor">J. Trollor</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff90">
<institution>Department of Developmental Disability Neuropsychiatry, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Trompet, S" sort="Trompet, S" uniqKey="Trompet S" first="S" last="Trompet">S. Trompet</name>
<affiliation wicri:level="1">
<nlm:aff id="aff22">
<institution>Department of Gerontology and Geriatrics, Leiden University Medical Center</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff91">
<institution>Department of Cardiology, Leiden University Medical Center</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Uitterlinden, A G" sort="Uitterlinden, A G" uniqKey="Uitterlinden A" first="A G" last="Uitterlinden">A G Uitterlinden</name>
<affiliation wicri:level="1">
<nlm:aff id="aff35">
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff36">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff92">
<institution>Department of Internal Medicine, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Weinstein, G" sort="Weinstein, G" uniqKey="Weinstein G" first="G" last="Weinstein">G. Weinstein</name>
<affiliation wicri:level="1">
<nlm:aff id="aff7">
<institution>Department of Neurology, Boston University School of Medicine</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff30">
<institution>Framingham Heart Study</institution>
, Framingham, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Widen, E" sort="Widen, E" uniqKey="Widen E" first="E" last="Widen">E. Widen</name>
<affiliation wicri:level="1">
<nlm:aff id="aff77">
<institution>Institute for Molecular Medicine Finland (FIMM), University of Helsinki</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Windham, B G" sort="Windham, B G" uniqKey="Windham B" first="B G" last="Windham">B G Windham</name>
<affiliation wicri:level="1">
<nlm:aff id="aff93">
<institution>Division of Geriatrics, Department of Medicine, University of Mississippi Medical Center</institution>
, Jackson, MS,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Jukema, J W" sort="Jukema, J W" uniqKey="Jukema J" first="J W" last="Jukema">J W Jukema</name>
<affiliation wicri:level="1">
<nlm:aff id="aff91">
<institution>Department of Cardiology, Leiden University Medical Center</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff94">
<institution>Durrer Center for Cardiogenetic Research</institution>
, Amsterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff95">
<institution>Interuniversity Cardiology Institute of the Netherlands</institution>
, Utrecht,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Wright, A F" sort="Wright, A F" uniqKey="Wright A" first="A F" last="Wright">A F Wright</name>
<affiliation wicri:level="1">
<nlm:aff id="aff29">
<institution>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Wright, M J" sort="Wright, M J" uniqKey="Wright M" first="M J" last="Wright">M J Wright</name>
<affiliation wicri:level="1">
<nlm:aff id="aff96">
<institution>Neuroimaging Genetics Group, QIMR Berghofer Medical Research Institute</institution>
, Brisbane, QLD,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Yang, Q" sort="Yang, Q" uniqKey="Yang Q" first="Q" last="Yang">Q. Yang</name>
<affiliation wicri:level="1">
<nlm:aff id="aff30">
<institution>Framingham Heart Study</institution>
, Framingham, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff31">
<institution>Department of Biostatistics, Boston University School of Public Health</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Amieva, H" sort="Amieva, H" uniqKey="Amieva H" first="H" last="Amieva">H. Amieva</name>
<affiliation wicri:level="1">
<nlm:aff id="aff52">
<institution>Inserm U897, Université Bordeaux Segalen</institution>
, Bordeaux,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Attia, J R" sort="Attia, J R" uniqKey="Attia J" first="J R" last="Attia">J R Attia</name>
<affiliation wicri:level="1">
<nlm:aff id="aff21">
<institution>Hunter Medical Research Institute and Faculty of Health, University of Newcastle</institution>
, Newcastle, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Bennett, D A" sort="Bennett, D A" uniqKey="Bennett D" first="D A" last="Bennett">D A Bennett</name>
<affiliation wicri:level="1">
<nlm:aff id="aff32">
<institution>Rush Alzheimer's Disease Center, Rush University Medical Center</institution>
, Chicago, IL,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Brodaty, H" sort="Brodaty, H" uniqKey="Brodaty H" first="H" last="Brodaty">H. Brodaty</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff97">
<institution>Dementia Collaborative Research Centre, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="De Craen, A J M" sort="De Craen, A J M" uniqKey="De Craen A" first="A J M" last="De Craen">A J M. De Craen</name>
<affiliation wicri:level="1">
<nlm:aff id="aff22">
<institution>Department of Gerontology and Geriatrics, Leiden University Medical Center</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff23">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hayward, C" sort="Hayward, C" uniqKey="Hayward C" first="C" last="Hayward">C. Hayward</name>
<affiliation wicri:level="1">
<nlm:aff id="aff29">
<institution>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ikram, M A" sort="Ikram, M A" uniqKey="Ikram M" first="M A" last="Ikram">M A Ikram</name>
<affiliation wicri:level="1">
<nlm:aff id="aff12">
<institution>Department of Neurology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff35">
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff36">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff98">
<institution>Department of Radiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lindenberger, U" sort="Lindenberger, U" uniqKey="Lindenberger U" first="U" last="Lindenberger">U. Lindenberger</name>
<affiliation wicri:level="1">
<nlm:aff id="aff17">
<institution>Max Planck Institute for Human Development</institution>
, Berlin,
<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Nilsson, L G" sort="Nilsson, L G" uniqKey="Nilsson L" first="L-G" last="Nilsson">L-G Nilsson</name>
<affiliation wicri:level="1">
<nlm:aff id="aff99">
<institution>ARC, Karolinska Institutet, Stockholm and UFBI, Umeå University</institution>
, Umeå,
<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Porteous, D J" sort="Porteous, D J" uniqKey="Porteous D" first="D J" last="Porteous">D J Porteous</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff19">
<institution>Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff60">
<institution>Generation Scotland, University of Edinburgh Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="R Ikkonen, K" sort="R Ikkonen, K" uniqKey="R Ikkonen K" first="K" last="R Ikkönen">K. R Ikkönen</name>
<affiliation wicri:level="1">
<nlm:aff id="aff15">
<institution>Institute of Behavioural Sciences, University of Helsinki</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Reinvang, I" sort="Reinvang, I" uniqKey="Reinvang I" first="I" last="Reinvang">I. Reinvang</name>
<affiliation wicri:level="1">
<nlm:aff id="aff57">
<institution>Department of Psychology, University of Oslo</institution>
, Oslo,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Rudan, I" sort="Rudan, I" uniqKey="Rudan I" first="I" last="Rudan">I. Rudan</name>
<affiliation wicri:level="1">
<nlm:aff id="aff14">
<institution>Centre for Population Health Sciences, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Sachdev, P S" sort="Sachdev, P S" uniqKey="Sachdev P" first="P S" last="Sachdev">P S Sachdev</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff65">
<institution>Neuropsychiatric Institute, Prince of Wales Hospital</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schmidt, R" sort="Schmidt, R" uniqKey="Schmidt R" first="R" last="Schmidt">R. Schmidt</name>
<affiliation wicri:level="1">
<nlm:aff id="aff10">
<institution>Department of Neurology, Medical University of Graz</institution>
, Graz,
<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schofield, P R" sort="Schofield, P R" uniqKey="Schofield P" first="P R" last="Schofield">P R Schofield</name>
<affiliation wicri:level="1">
<nlm:aff id="aff100">
<institution>Neuroscience Research Australia</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff101">
<institution>Faculty of Medicine, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Srikanth, V" sort="Srikanth, V" uniqKey="Srikanth V" first="V" last="Srikanth">V. Srikanth</name>
<affiliation>
<nlm:aff id="aff28">
<institution>Menzies Research Institute</institution>
, Hobart,
<country>Tasmania</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Tasmania</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff102">
<institution>Stroke and Ageing Research, Medicine, Southern Clinical School, Monash University</institution>
, Melbourne, VIC,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Starr, J M" sort="Starr, J M" uniqKey="Starr J" first="J M" last="Starr">J M Starr</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff103">
<institution>Alzheimer Scotland Dementia Research Centre, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Turner, S T" sort="Turner, S T" uniqKey="Turner S" first="S T" last="Turner">S T Turner</name>
<affiliation wicri:level="1">
<nlm:aff id="aff104">
<institution>Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic</institution>
, Rochester, MN,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Weir, D R" sort="Weir, D R" uniqKey="Weir D" first="D R" last="Weir">D R Weir</name>
<affiliation wicri:level="1">
<nlm:aff id="aff58">
<institution>Survey Research Center, Institute for Social Research, University of Michigan</institution>
, Ann Arbor, MI,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Wilson, J F" sort="Wilson, J F" uniqKey="Wilson J" first="J F" last="Wilson">J F Wilson</name>
<affiliation wicri:level="1">
<nlm:aff id="aff14">
<institution>Centre for Population Health Sciences, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Van Duijn, C" sort="Van Duijn, C" uniqKey="Van Duijn C" first="C" last="Van Duijn">C. Van Duijn</name>
<affiliation wicri:level="1">
<nlm:aff id="aff13">
<institution>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff36">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Launer, L" sort="Launer, L" uniqKey="Launer L" first="L" last="Launer">L. Launer</name>
<affiliation wicri:level="1">
<nlm:aff id="aff63">
<institution>Intramural Research Program National Institutes on Aging, National Institutes of Health</institution>
, Bethesda, MD,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Fitzpatrick, A L" sort="Fitzpatrick, A L" uniqKey="Fitzpatrick A" first="A L" last="Fitzpatrick">A L Fitzpatrick</name>
<affiliation wicri:level="1">
<nlm:aff id="aff81">
<institution>Deparment of Epidemiology, University of Washington</institution>
, Seattle, WA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff105">
<institution>Department of Global Health, University of Washington</institution>
, Seattle, WA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Seshadri, S" sort="Seshadri, S" uniqKey="Seshadri S" first="S" last="Seshadri">S. Seshadri</name>
<affiliation wicri:level="1">
<nlm:aff id="aff7">
<institution>Department of Neurology, Boston University School of Medicine</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff30">
<institution>Framingham Heart Study</institution>
, Framingham, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Mosley, T H" sort="Mosley, T H" uniqKey="Mosley T" first="T H" last="Mosley">T H Mosley</name>
<affiliation wicri:level="1">
<nlm:aff id="aff93">
<institution>Division of Geriatrics, Department of Medicine, University of Mississippi Medical Center</institution>
, Jackson, MS,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Deary, I J" sort="Deary, I J" uniqKey="Deary I" first="I J" last="Deary">I J Deary</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Department of Psychology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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</analytic>
<series>
<title level="j">Molecular Psychiatry</title>
<idno type="ISSN">1359-4184</idno>
<idno type="eISSN">1476-5578</idno>
<imprint>
<date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass></textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<p>General cognitive function is substantially heritable across the human life course from adolescence to old age. We investigated the genetic contribution to variation in this important, health- and well-being-related trait in middle-aged and older adults. We conducted a meta-analysis of genome-wide association studies of 31 cohorts (
<italic>N</italic>
=53 949) in which the participants had undertaken multiple, diverse cognitive tests. A general cognitive function phenotype was tested for, and created in each cohort by principal component analysis. We report 13 genome-wide significant single-nucleotide polymorphism (SNP) associations in three genomic regions, 6q16.1, 14q12 and 19q13.32 (best SNP and closest gene, respectively: rs10457441,
<italic>P</italic>
=3.93 × 10
<sup>−9</sup>
,
<italic>MIR2113</italic>
; rs17522122,
<italic>P</italic>
=2.55 × 10
<sup>−8</sup>
,
<italic>AKAP6</italic>
; rs10119,
<italic>P</italic>
=5.67 × 10
<sup>−9</sup>
,
<italic>APOE/TOMM40</italic>
). We report one gene-based significant association with the
<italic>HMGN1</italic>
gene located on chromosome 21 (
<italic>P</italic>
=1 × 10
<sup>−6</sup>
). These genes have previously been associated with neuropsychiatric phenotypes. Meta-analysis results are consistent with a polygenic model of inheritance. To estimate SNP-based heritability, the genome-wide complex trait analysis procedure was applied to two large cohorts, the Atherosclerosis Risk in Communities Study (
<italic>N</italic>
=6617) and the Health and Retirement Study (
<italic>N</italic>
=5976). The proportion of phenotypic variation accounted for by all genotyped common SNPs was 29% (s.e.=5%) and 28% (s.e.=7%), respectively. Using polygenic prediction analysis, ~1.2% of the variance in general cognitive function was predicted in the Generation Scotland cohort (
<italic>N</italic>
=5487;
<italic>P</italic>
=1.5 × 10
<sup>−17</sup>
). In hypothesis-driven tests, there was significant association between general cognitive function and four genes previously associated with Alzheimer's disease:
<italic>TOMM40</italic>
,
<italic>APOE</italic>
,
<italic>ABCG1</italic>
and
<italic>MEF2C</italic>
.</p>
</div>
</front>
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<xref ref-type="aff" rid="aff78">78</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Papenberg</surname>
<given-names>G</given-names>
</name>
<xref ref-type="aff" rid="aff17">17</xref>
<xref ref-type="aff" rid="aff79">79</xref>
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<name>
<surname>Pattie</surname>
<given-names>A</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
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<name>
<surname>Petrovic</surname>
<given-names>K</given-names>
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<xref ref-type="aff" rid="aff10">10</xref>
</contrib>
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<name>
<surname>Polasek</surname>
<given-names>O</given-names>
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<xref ref-type="aff" rid="aff80">80</xref>
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<xref ref-type="aff" rid="aff4">4</xref>
<xref ref-type="aff" rid="aff81">81</xref>
<xref ref-type="aff" rid="aff82">82</xref>
<xref ref-type="aff" rid="aff83">83</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Redmond</surname>
<given-names>P</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
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<name>
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<given-names>S</given-names>
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<xref ref-type="aff" rid="aff27">27</xref>
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<name>
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<given-names>J I</given-names>
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<xref ref-type="aff" rid="aff84">84</xref>
<xref ref-type="aff" rid="aff85">85</xref>
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<contrib contrib-type="author">
<name>
<surname>Schmidt</surname>
<given-names>H</given-names>
</name>
<xref ref-type="aff" rid="aff10">10</xref>
<xref ref-type="aff" rid="aff86">86</xref>
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<name>
<surname>Schuur</surname>
<given-names>M</given-names>
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<xref ref-type="aff" rid="aff12">12</xref>
<xref ref-type="aff" rid="aff13">13</xref>
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<name>
<surname>Schofield</surname>
<given-names>P W</given-names>
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<xref ref-type="aff" rid="aff87">87</xref>
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<name>
<surname>Scott</surname>
<given-names>R J</given-names>
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<xref ref-type="aff" rid="aff21">21</xref>
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<given-names>V M</given-names>
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<xref ref-type="aff" rid="aff8">8</xref>
<xref ref-type="aff" rid="aff9">9</xref>
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<name>
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<given-names>D J</given-names>
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<xref ref-type="aff" rid="aff88">88</xref>
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<given-names>J C</given-names>
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<xref ref-type="aff" rid="aff12">12</xref>
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<given-names>K D</given-names>
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<xref ref-type="aff" rid="aff84">84</xref>
<xref ref-type="aff" rid="aff89">89</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Trollor</surname>
<given-names>J</given-names>
</name>
<xref ref-type="aff" rid="aff27">27</xref>
<xref ref-type="aff" rid="aff90">90</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Trompet</surname>
<given-names>S</given-names>
</name>
<xref ref-type="aff" rid="aff22">22</xref>
<xref ref-type="aff" rid="aff91">91</xref>
</contrib>
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<name>
<surname>Uitterlinden</surname>
<given-names>A G</given-names>
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<xref ref-type="aff" rid="aff35">35</xref>
<xref ref-type="aff" rid="aff36">36</xref>
<xref ref-type="aff" rid="aff92">92</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Weinstein</surname>
<given-names>G</given-names>
</name>
<xref ref-type="aff" rid="aff7">7</xref>
<xref ref-type="aff" rid="aff30">30</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Widen</surname>
<given-names>E</given-names>
</name>
<xref ref-type="aff" rid="aff77">77</xref>
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<given-names>B G</given-names>
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<xref ref-type="aff" rid="aff93">93</xref>
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<given-names>J W</given-names>
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<xref ref-type="aff" rid="aff91">91</xref>
<xref ref-type="aff" rid="aff94">94</xref>
<xref ref-type="aff" rid="aff95">95</xref>
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<name>
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<given-names>A F</given-names>
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<xref ref-type="aff" rid="aff29">29</xref>
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<given-names>M J</given-names>
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<xref ref-type="aff" rid="aff96">96</xref>
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<given-names>Q</given-names>
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<xref ref-type="aff" rid="aff30">30</xref>
<xref ref-type="aff" rid="aff31">31</xref>
</contrib>
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<name>
<surname>Amieva</surname>
<given-names>H</given-names>
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<xref ref-type="aff" rid="aff52">52</xref>
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<xref ref-type="aff" rid="aff21">21</xref>
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<xref ref-type="aff" rid="aff32">32</xref>
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<given-names>H</given-names>
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<xref ref-type="aff" rid="aff27">27</xref>
<xref ref-type="aff" rid="aff97">97</xref>
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<xref ref-type="aff" rid="aff22">22</xref>
<xref ref-type="aff" rid="aff23">23</xref>
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<given-names>C</given-names>
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<xref ref-type="aff" rid="aff12">12</xref>
<xref ref-type="aff" rid="aff35">35</xref>
<xref ref-type="aff" rid="aff36">36</xref>
<xref ref-type="aff" rid="aff98">98</xref>
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<given-names>U</given-names>
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<xref ref-type="aff" rid="aff17">17</xref>
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<given-names>L-G</given-names>
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<xref ref-type="aff" rid="aff99">99</xref>
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<given-names>D J</given-names>
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<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff19">19</xref>
<xref ref-type="aff" rid="aff60">60</xref>
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<given-names>K</given-names>
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<xref ref-type="aff" rid="aff15">15</xref>
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<contrib contrib-type="author">
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<given-names>I</given-names>
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<xref ref-type="aff" rid="aff57">57</xref>
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<given-names>I</given-names>
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<xref ref-type="aff" rid="aff14">14</xref>
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<xref ref-type="aff" rid="aff27">27</xref>
<xref ref-type="aff" rid="aff65">65</xref>
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<name>
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<given-names>R</given-names>
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<xref ref-type="aff" rid="aff10">10</xref>
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<given-names>P R</given-names>
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<xref ref-type="aff" rid="aff100">100</xref>
<xref ref-type="aff" rid="aff101">101</xref>
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<name>
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<given-names>V</given-names>
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<xref ref-type="aff" rid="aff28">28</xref>
<xref ref-type="aff" rid="aff102">102</xref>
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<given-names>J M</given-names>
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<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff103">103</xref>
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<given-names>S T</given-names>
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<given-names>D R</given-names>
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<xref ref-type="aff" rid="aff58">58</xref>
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<xref ref-type="aff" rid="aff14">14</xref>
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<given-names>C</given-names>
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<xref ref-type="aff" rid="aff13">13</xref>
<xref ref-type="aff" rid="aff36">36</xref>
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<name>
<surname>Launer</surname>
<given-names>L</given-names>
</name>
<xref ref-type="aff" rid="aff63">63</xref>
</contrib>
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<name>
<surname>Fitzpatrick</surname>
<given-names>A L</given-names>
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<xref ref-type="aff" rid="aff81">81</xref>
<xref ref-type="aff" rid="aff105">105</xref>
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<name>
<surname>Seshadri</surname>
<given-names>S</given-names>
</name>
<xref ref-type="aff" rid="aff7">7</xref>
<xref ref-type="aff" rid="aff30">30</xref>
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<name>
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<given-names>T H</given-names>
<suffix>Jr</suffix>
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<xref ref-type="aff" rid="aff93">93</xref>
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<given-names>I J</given-names>
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<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
<xref ref-type="corresp" rid="caf1">*</xref>
</contrib>
<aff id="aff1">
<label>1</label>
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</aff>
<aff id="aff2">
<label>2</label>
<institution>Department of Psychology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</aff>
<aff id="aff3">
<label>3</label>
<institution>School of Mathematics and Statistics, University of Sydney</institution>
, Sydney, NSW,
<country>Australia</country>
</aff>
<aff id="aff4">
<label>4</label>
<institution>Cardiovascular Health Research Unit, Department of Medicine, University of Washington</institution>
, Seattle, WA,
<country>USA</country>
</aff>
<aff id="aff5">
<label>5</label>
<institution>Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston</institution>
, Houston, TX,
<country>USA</country>
</aff>
<aff id="aff6">
<label>6</label>
<institution>Inserm-UMR744, Institut Pasteur de Lille, Unité d'Epidémiologie et de Santé Publique</institution>
, Lille,
<country>France</country>
</aff>
<aff id="aff7">
<label>7</label>
<institution>Department of Neurology, Boston University School of Medicine</institution>
, Boston, MA,
<country>USA</country>
</aff>
<aff id="aff8">
<label>8</label>
<institution>K.G. Jebsen Centre for Psychosis Research and the Norwegian Centre for Mental Disorders Research (NORMENT), Department of Clinical Science, University of Bergen</institution>
, Bergen,
<country>Norway</country>
</aff>
<aff id="aff9">
<label>9</label>
<institution>Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital</institution>
, Bergen,
<country>Norway</country>
</aff>
<aff id="aff10">
<label>10</label>
<institution>Department of Neurology, Medical University of Graz</institution>
, Graz,
<country>Austria</country>
</aff>
<aff id="aff11">
<label>11</label>
<institution>Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz</institution>
, Graz,
<country>Austria</country>
</aff>
<aff id="aff12">
<label>12</label>
<institution>Department of Neurology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</aff>
<aff id="aff13">
<label>13</label>
<institution>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</aff>
<aff id="aff14">
<label>14</label>
<institution>Centre for Population Health Sciences, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</aff>
<aff id="aff15">
<label>15</label>
<institution>Institute of Behavioural Sciences, University of Helsinki</institution>
, Helsinki,
<country>Finland</country>
</aff>
<aff id="aff16">
<label>16</label>
<institution>Folkhälsan Research Centre</institution>
, Helsinki,
<country>Finland</country>
</aff>
<aff id="aff17">
<label>17</label>
<institution>Max Planck Institute for Human Development</institution>
, Berlin,
<country>Germany</country>
</aff>
<aff id="aff18">
<label>18</label>
<institution>Max Planck Institute for Molecular Genetics</institution>
, Berlin,
<country>Germany</country>
</aff>
<aff id="aff19">
<label>19</label>
<institution>Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital</institution>
, Edinburgh,
<country>UK</country>
</aff>
<aff id="aff20">
<label>20</label>
<institution>Queensland Brain Institute, The University of Queensland</institution>
, Brisbane, QLD,
<country>Australia</country>
</aff>
<aff id="aff21">
<label>21</label>
<institution>Hunter Medical Research Institute and Faculty of Health, University of Newcastle</institution>
, Newcastle, NSW,
<country>Australia</country>
</aff>
<aff id="aff22">
<label>22</label>
<institution>Department of Gerontology and Geriatrics, Leiden University Medical Center</institution>
, Leiden,
<country>The Netherlands</country>
</aff>
<aff id="aff23">
<label>23</label>
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</aff>
<aff id="aff24">
<label>24</label>
<institution>Icelandic Heart Association</institution>
, Kopavogur,
<country>Iceland</country>
</aff>
<aff id="aff25">
<label>25</label>
<institution>University of Iceland</institution>
, Reykjavik,
<country>Iceland</country>
</aff>
<aff id="aff26">
<label>26</label>
<institution>Department of Epidemiology, University of Michigan</institution>
, Ann Arbor, MI,
<country>USA</country>
</aff>
<aff id="aff27">
<label>27</label>
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</aff>
<aff id="aff28">
<label>28</label>
<institution>Menzies Research Institute</institution>
, Hobart,
<country>Tasmania</country>
</aff>
<aff id="aff29">
<label>29</label>
<institution>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</aff>
<aff id="aff30">
<label>30</label>
<institution>Framingham Heart Study</institution>
, Framingham, MA,
<country>USA</country>
</aff>
<aff id="aff31">
<label>31</label>
<institution>Department of Biostatistics, Boston University School of Public Health</institution>
, Boston, MA,
<country>USA</country>
</aff>
<aff id="aff32">
<label>32</label>
<institution>Rush Alzheimer's Disease Center, Rush University Medical Center</institution>
, Chicago, IL,
<country>USA</country>
</aff>
<aff id="aff33">
<label>33</label>
<institution>Department of Public Health and Primary Care, Trinity College Dublin</institution>
, Dublin,
<country>Ireland</country>
</aff>
<aff id="aff34">
<label>34</label>
<institution>Andrija Stampar School of Public Health, Medical School, University of Zagreb</institution>
, Zagreb,
<country>Croatia</country>
</aff>
<aff id="aff35">
<label>35</label>
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</aff>
<aff id="aff36">
<label>36</label>
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</aff>
<aff id="aff37">
<label>37</label>
<institution>National Ageing Research Institute, Royal Melbourne Hospital</institution>
, Melbourne, VIC,
<country>Australia</country>
</aff>
<aff id="aff38">
<label>38</label>
<institution>Academic Unit for Psychiatry of Old Age, St George's Hospital, University of Melbourne</institution>
, Kew,
<country>Australia</country>
</aff>
<aff id="aff39">
<label>39</label>
<institution>Department of Neurology, University of Pittsburgh</institution>
, Pittsburgh, PA,
<country>USA</country>
</aff>
<aff id="aff40">
<label>40</label>
<institution>Department of Psychiatry, University of Pittsburgh</institution>
, Pittsburgh, PA,
<country>USA</country>
</aff>
<aff id="aff41">
<label>41</label>
<institution>Department of Psychology, University of Pittsburgh</institution>
, Pittsburgh, PA,
<country>USA</country>
</aff>
<aff id="aff42">
<label>42</label>
<institution>Inserm, U106</institution>
, Montpellier,
<country>France</country>
</aff>
<aff id="aff43">
<label>43</label>
<institution>Université Montpellier I</institution>
, Montpellier,
<country>France</country>
</aff>
<aff id="aff44">
<label>44</label>
<institution>Faculty of Medicine, School of Public Health, Imperial College</institution>
, London,
<country>UK</country>
</aff>
<aff id="aff45">
<label>45</label>
<institution>Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Health Science Center at Houston</institution>
, Houston, TX,
<country>USA</country>
</aff>
<aff id="aff46">
<label>46</label>
<institution>Human Genome Sequencing Center, Baylor College of Medicine</institution>
, Houston, TX,
<country>USA</country>
</aff>
<aff id="aff47">
<label>47</label>
<institution>Department of Pharmacology and Therapeutics, University College Cork</institution>
, Cork,
<country>Ireland</country>
</aff>
<aff id="aff48">
<label>48</label>
<institution>Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital</institution>
, Boston, MA,
<country>USA</country>
</aff>
<aff id="aff49">
<label>49</label>
<institution>Harvard Medical School</institution>
, Boston, MA,
<country>USA</country>
</aff>
<aff id="aff50">
<label>50</label>
<institution>Program in Medical and Population Genetics, Broad Institute</institution>
, Cambridge, MA,
<country>USA</country>
</aff>
<aff id="aff51">
<label>51</label>
<institution>Inserm U708, Neuroepidemiology</institution>
, Paris,
<country>France</country>
</aff>
<aff id="aff52">
<label>52</label>
<institution>Inserm U897, Université Bordeaux Segalen</institution>
, Bordeaux,
<country>France</country>
</aff>
<aff id="aff53">
<label>53</label>
<institution>National Institute for Health and Welfare</institution>
, Helsinki,
<country>Finland</country>
</aff>
<aff id="aff54">
<label>54</label>
<institution>Department of General Practice and Primary health Care, University of Helsinki</institution>
, Helsinki,
<country>Finland</country>
</aff>
<aff id="aff55">
<label>55</label>
<institution>Unit of General Practice, Helsinki University Central Hospital</institution>
, Helsinki,
<country>Finland</country>
</aff>
<aff id="aff56">
<label>56</label>
<institution>K.G. Jebsen Centre for Psychosis Research, Norwegian Centre For Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo</institution>
, Oslo,
<country>Norway</country>
</aff>
<aff id="aff57">
<label>57</label>
<institution>Department of Psychology, University of Oslo</institution>
, Oslo,
<country>Norway</country>
</aff>
<aff id="aff58">
<label>58</label>
<institution>Survey Research Center, Institute for Social Research, University of Michigan</institution>
, Ann Arbor, MI,
<country>USA</country>
</aff>
<aff id="aff59">
<label>59</label>
<institution>Robertson Center for Biostatistics</institution>
, Glasgow,
<country>UK</country>
</aff>
<aff id="aff60">
<label>60</label>
<institution>Generation Scotland, University of Edinburgh Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital</institution>
, Edinburgh,
<country>UK</country>
</aff>
<aff id="aff61">
<label>61</label>
<institution>Department of Neurology, Johns Hopkins University School of Medicine</institution>
, Baltimore, MD,
<country>USA</country>
</aff>
<aff id="aff62">
<label>62</label>
<institution>Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center</institution>
, Jackson, MS,
<country>USA</country>
</aff>
<aff id="aff63">
<label>63</label>
<institution>Intramural Research Program National Institutes on Aging, National Institutes of Health</institution>
, Bethesda, MD,
<country>USA</country>
</aff>
<aff id="aff64">
<label>64</label>
<institution>Department of Epidemiology, University of North Carolina Gillings School of Global Public Health</institution>
, Chapel Hill, NC,
<country>USA</country>
</aff>
<aff id="aff65">
<label>65</label>
<institution>Neuropsychiatric Institute, Prince of Wales Hospital</institution>
, Sydney, NSW,
<country>Australia</country>
</aff>
<aff id="aff66">
<label>66</label>
<institution>Department of Neurology, Mayo Clinic</institution>
, Rochester, MN,
<country>USA</country>
</aff>
<aff id="aff67">
<label>67</label>
<institution>Neuroscience Research Australia</institution>
, Randwick, NSW,
<country>Australia</country>
</aff>
<aff id="aff68">
<label>68</label>
<institution>School of Medical Sciences, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</aff>
<aff id="aff69">
<label>69</label>
<institution>Technische Universität Dresden</institution>
, Dresden,
<country>Germany</country>
</aff>
<aff id="aff70">
<label>70</label>
<institution>Department of Biological and Medical Psychology, University of Bergen</institution>
, Bergen,
<country>Norway</country>
</aff>
<aff id="aff71">
<label>71</label>
<institution>Kavli Research Centre for Aging and Dementia, Haraldsplass Deaconess Hospital</institution>
, Bergen,
<country>Norway</country>
</aff>
<aff id="aff72">
<label>72</label>
<institution>K.G. Jebsen Centre for Research on Neuropsychiatric Disorders, University of Bergen</institution>
, Bergen,
<country>Norway</country>
</aff>
<aff id="aff73">
<label>73</label>
<institution>Umeå Center for Functional Brain Imaging (UFBI), Umeå University</institution>
, Umeå,
<country>Sweden</country>
</aff>
<aff id="aff74">
<label>74</label>
<institution>Department of Radiation Sciences, Umeå University</institution>
, Umeå,
<country>Sweden</country>
</aff>
<aff id="aff75">
<label>75</label>
<institution>Department of Integrative Medical Biology, Umeå University</institution>
, Umeå,
<country>Sweden</country>
</aff>
<aff id="aff76">
<label>76</label>
<institution>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus</institution>
, Cambridge,
<country>UK</country>
</aff>
<aff id="aff77">
<label>77</label>
<institution>Institute for Molecular Medicine Finland (FIMM), University of Helsinki</institution>
, Helsinki,
<country>Finland</country>
</aff>
<aff id="aff78">
<label>78</label>
<institution>Department of Medical Genetics, University of Helsinki and University Central Hospital</institution>
, Helsinki,
<country>Finland</country>
</aff>
<aff id="aff79">
<label>79</label>
<institution>Karolinska Institutet, Aging Research Center, Stockholm University</institution>
, Stockholm,
<country>Sweden</country>
</aff>
<aff id="aff80">
<label>80</label>
<institution>Faculty of Medicine, Department of Public Health, University of Split</institution>
, Split,
<country>Croatia</country>
</aff>
<aff id="aff81">
<label>81</label>
<institution>Deparment of Epidemiology, University of Washington</institution>
, Seattle, WA,
<country>USA</country>
</aff>
<aff id="aff82">
<label>82</label>
<institution>Deparment of Health Services, University of Washington</institution>
, Seattle, WA,
<country>USA</country>
</aff>
<aff id="aff83">
<label>83</label>
<institution>Group Health Research Unit, Group Health Cooperative</institution>
, Seattle, WA,
<country>USA</country>
</aff>
<aff id="aff84">
<label>84</label>
<institution>Institute for Translational Genomics and Population Sciences Los Angeles BioMedical Research Institute, Harbor-UCLA Medical Center</institution>
, Los Angeles, CA,
<country>USA</country>
</aff>
<aff id="aff85">
<label>85</label>
<institution>Division of Genetic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center</institution>
, Los Angeles, CA,
<country>USA</country>
</aff>
<aff id="aff86">
<label>86</label>
<institution>Centre for Molecular Medicine, Institute of Molecular Biology and Biochemistry, Medical University of Graz</institution>
, Graz,
<country>Austria</country>
</aff>
<aff id="aff87">
<label>87</label>
<institution>School of Medicine and Public Health, University of Newcastle</institution>
, Newcastle, NSW,
<country>Australia</country>
</aff>
<aff id="aff88">
<label>88</label>
<institution>Institute of Cardiovascular and Medical Sciences, University of Glasgow</institution>
, Glasgow,
<country>UK</country>
</aff>
<aff id="aff89">
<label>89</label>
<institution>Department of Pediatrics, Harbor-UCLA Medical Center</institution>
, Los Angeles, CA,
<country>USA</country>
</aff>
<aff id="aff90">
<label>90</label>
<institution>Department of Developmental Disability Neuropsychiatry, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</aff>
<aff id="aff91">
<label>91</label>
<institution>Department of Cardiology, Leiden University Medical Center</institution>
, Leiden,
<country>The Netherlands</country>
</aff>
<aff id="aff92">
<label>92</label>
<institution>Department of Internal Medicine, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</aff>
<aff id="aff93">
<label>93</label>
<institution>Division of Geriatrics, Department of Medicine, University of Mississippi Medical Center</institution>
, Jackson, MS,
<country>USA</country>
</aff>
<aff id="aff94">
<label>94</label>
<institution>Durrer Center for Cardiogenetic Research</institution>
, Amsterdam,
<country>The Netherlands</country>
</aff>
<aff id="aff95">
<label>95</label>
<institution>Interuniversity Cardiology Institute of the Netherlands</institution>
, Utrecht,
<country>The Netherlands</country>
</aff>
<aff id="aff96">
<label>96</label>
<institution>Neuroimaging Genetics Group, QIMR Berghofer Medical Research Institute</institution>
, Brisbane, QLD,
<country>Australia</country>
</aff>
<aff id="aff97">
<label>97</label>
<institution>Dementia Collaborative Research Centre, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</aff>
<aff id="aff98">
<label>98</label>
<institution>Department of Radiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</aff>
<aff id="aff99">
<label>99</label>
<institution>ARC, Karolinska Institutet, Stockholm and UFBI, Umeå University</institution>
, Umeå,
<country>Sweden</country>
</aff>
<aff id="aff100">
<label>100</label>
<institution>Neuroscience Research Australia</institution>
, Sydney, NSW,
<country>Australia</country>
</aff>
<aff id="aff101">
<label>101</label>
<institution>Faculty of Medicine, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</aff>
<aff id="aff102">
<label>102</label>
<institution>Stroke and Ageing Research, Medicine, Southern Clinical School, Monash University</institution>
, Melbourne, VIC,
<country>Australia</country>
</aff>
<aff id="aff103">
<label>103</label>
<institution>Alzheimer Scotland Dementia Research Centre, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</aff>
<aff id="aff104">
<label>104</label>
<institution>Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic</institution>
, Rochester, MN,
<country>USA</country>
</aff>
<aff id="aff105">
<label>105</label>
<institution>Department of Global Health, University of Washington</institution>
, Seattle, WA,
<country>USA</country>
</aff>
</contrib-group>
<author-notes>
<corresp id="caf1">
<label>*</label>
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh</institution>
, 7 George Square, Edinburgh EH8 9JZ,
<country>Scotland, UK</country>
. E-mail:
<email>i.deary@ed.ac.uk</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub">
<month>02</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub">
<day>03</day>
<month>02</month>
<year>2015</year>
</pub-date>
<volume>20</volume>
<issue>2</issue>
<fpage>183</fpage>
<lpage>192</lpage>
<history>
<date date-type="received">
<day>17</day>
<month>10</month>
<year>2014</year>
</date>
<date date-type="rev-recd">
<day>11</day>
<month>11</month>
<year>2014</year>
</date>
<date date-type="accepted">
<day>24</day>
<month>11</month>
<year>2014</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright © 2015 Macmillan Publishers Limited</copyright-statement>
<copyright-year>2015</copyright-year>
<copyright-holder>Macmillan Publishers Limited</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/">
<pmc-comment>author-paid</pmc-comment>
<license-p>This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
</license-p>
</license>
</permissions>
<abstract>
<p>General cognitive function is substantially heritable across the human life course from adolescence to old age. We investigated the genetic contribution to variation in this important, health- and well-being-related trait in middle-aged and older adults. We conducted a meta-analysis of genome-wide association studies of 31 cohorts (
<italic>N</italic>
=53 949) in which the participants had undertaken multiple, diverse cognitive tests. A general cognitive function phenotype was tested for, and created in each cohort by principal component analysis. We report 13 genome-wide significant single-nucleotide polymorphism (SNP) associations in three genomic regions, 6q16.1, 14q12 and 19q13.32 (best SNP and closest gene, respectively: rs10457441,
<italic>P</italic>
=3.93 × 10
<sup>−9</sup>
,
<italic>MIR2113</italic>
; rs17522122,
<italic>P</italic>
=2.55 × 10
<sup>−8</sup>
,
<italic>AKAP6</italic>
; rs10119,
<italic>P</italic>
=5.67 × 10
<sup>−9</sup>
,
<italic>APOE/TOMM40</italic>
). We report one gene-based significant association with the
<italic>HMGN1</italic>
gene located on chromosome 21 (
<italic>P</italic>
=1 × 10
<sup>−6</sup>
). These genes have previously been associated with neuropsychiatric phenotypes. Meta-analysis results are consistent with a polygenic model of inheritance. To estimate SNP-based heritability, the genome-wide complex trait analysis procedure was applied to two large cohorts, the Atherosclerosis Risk in Communities Study (
<italic>N</italic>
=6617) and the Health and Retirement Study (
<italic>N</italic>
=5976). The proportion of phenotypic variation accounted for by all genotyped common SNPs was 29% (s.e.=5%) and 28% (s.e.=7%), respectively. Using polygenic prediction analysis, ~1.2% of the variance in general cognitive function was predicted in the Generation Scotland cohort (
<italic>N</italic>
=5487;
<italic>P</italic>
=1.5 × 10
<sup>−17</sup>
). In hypothesis-driven tests, there was significant association between general cognitive function and four genes previously associated with Alzheimer's disease:
<italic>TOMM40</italic>
,
<italic>APOE</italic>
,
<italic>ABCG1</italic>
and
<italic>MEF2C</italic>
.</p>
</abstract>
</article-meta>
</front>
<floats-group>
<fig id="fig1">
<label>Figure 1</label>
<caption>
<p>Manhattan (
<bold>a</bold>
) and Q–Q (
<bold>b</bold>
) plots of
<italic>P</italic>
-values of the association between single-nucleotide polymorphisms (SNPs) and general cognitive function in the meta-analysis. The threshold for genome-wide significance (
<italic>P</italic>
<5 × 10
<sup>−8</sup>
) is indicated by the red line and the threshold for suggestive significance (
<italic>P</italic>
<1 × 10
<sup>−5</sup>
) is indicated by the blue line.</p>
</caption>
<graphic xlink:href="mp2014188f1"></graphic>
</fig>
<fig id="fig2">
<label>Figure 2</label>
<caption>
<p>Regional association plots of genomic regions, which demonstrated genome-wide significance (
<italic>P</italic>
<5 × 10
<sup>−8</sup>
) in the meta-analysis, for chromosomes 6 (
<bold>a</bold>
), 14 (
<bold>b</bold>
) and 19 (
<bold>c</bold>
). The circles represent each genotyped single-nucleotide polymorphism (SNP), with the color indicating pairwise linkage disequilibrium (LD) in relation to the top hit (calculated from 1000 Genomes Nov 2010 EUR); −log10
<italic>P</italic>
-values are also indicated (
<italic>y</italic>
axis). The purple diamond represents the top SNP in each region. The solid blue line indicates the recombination rate.</p>
</caption>
<graphic xlink:href="mp2014188f2"></graphic>
</fig>
<fig id="fig3">
<label>Figure 3</label>
<caption>
<p>Plot of effect size against mean age of cohort for rs10119 (top SNP
<italic>APOE/TOMM40</italic>
region). Each numbered point represents a cohort (1, RSIII; 2, ERF; 3, SPLIT; 4, GS; 5, KORCULA; 6, NCNG; 7, GENOA; 8, ORCADES; 9, RSI; 10, FHS; 11, ASPS; 12, BASEII; 13, BETULA; 14, HCS; 15, RSII; 16, HBCS; 17, LBC1936; 18, HRS; 19, OATS; 20, TASCOG; 21, 3C; 22, PROSPER-Netherlands; 23, ROS; 24, PROSPER-Scotland; 25, PROSPER-Ireland; 26, AGES; 27, LBC1921; 28, CHS; 29, MAP). Two cohorts (ARIC and Sydney MAS) did not have data available for rs10119. Dashed regression line and shaded 95% confidence interval are shown. For full details of abbreviations, see
<xref ref-type="supplementary-material" rid="sup1">Supplementary Information 2</xref>
: Cohort Abbreviations.</p>
</caption>
<graphic xlink:href="mp2014188f3"></graphic>
</fig>
<fig id="fig4">
<label>Figure 4</label>
<caption>
<p>Forest plot of four GCTA-based estimates for the single-nucleotide polymorphism (SNP)-based heritability (
<italic>x</italic>
axis) of general fluid cognitive function. The summary mean and s.e. were estimated using inverse-variance weighting. Abbreviations: ARIC, The Atherosclerosis Risk in Communities Study; CAGES, Cognitive Ageing Genetics in England and Scotland Consortium;
<sup>
<xref ref-type="bibr" rid="bib30">30</xref>
</sup>
GS, Generation Scotland.
<sup>
<xref ref-type="bibr" rid="bib78">78</xref>
</sup>
HRS, Health and Retirement Study.</p>
</caption>
<graphic xlink:href="mp2014188f4"></graphic>
</fig>
</floats-group>
</pmc>
<affiliations>
<list>
<country>
<li>Allemagne</li>
<li>Australie</li>
<li>Autriche</li>
<li>Croatie</li>
<li>Finlande</li>
<li>France</li>
<li>Irlande (pays)</li>
<li>Islande</li>
<li>Norvège</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
</list>
<tree>
<noCountry>
<name sortKey="Thomson, R" sort="Thomson, R" uniqKey="Thomson R" first="R" last="Thomson">R. Thomson</name>
</noCountry>
<country name="Royaume-Uni">
<noRegion>
<name sortKey="Davies, G" sort="Davies, G" uniqKey="Davies G" first="G" last="Davies">G. Davies</name>
</noRegion>
<name sortKey="Bertram, L" sort="Bertram, L" uniqKey="Bertram L" first="L" last="Bertram">L. Bertram</name>
<name sortKey="Boxall, R" sort="Boxall, R" uniqKey="Boxall R" first="R" last="Boxall">R. Boxall</name>
<name sortKey="Campbell, H" sort="Campbell, H" uniqKey="Campbell H" first="H" last="Campbell">H. Campbell</name>
<name sortKey="Corley, J" sort="Corley, J" uniqKey="Corley J" first="J" last="Corley">J. Corley</name>
<name sortKey="Davies, G" sort="Davies, G" uniqKey="Davies G" first="G" last="Davies">G. Davies</name>
<name sortKey="Deary, I J" sort="Deary, I J" uniqKey="Deary I" first="I J" last="Deary">I J Deary</name>
<name sortKey="Deary, I J" sort="Deary, I J" uniqKey="Deary I" first="I J" last="Deary">I J Deary</name>
<name sortKey="Ford, I" sort="Ford, I" uniqKey="Ford I" first="I" last="Ford">I. Ford</name>
<name sortKey="Harris, S E" sort="Harris, S E" uniqKey="Harris S" first="S E" last="Harris">S E Harris</name>
<name sortKey="Harris, S E" sort="Harris, S E" uniqKey="Harris S" first="S E" last="Harris">S E Harris</name>
<name sortKey="Hayward, C" sort="Hayward, C" uniqKey="Hayward C" first="C" last="Hayward">C. Hayward</name>
<name sortKey="Hill, W D" sort="Hill, W D" uniqKey="Hill W" first="W D" last="Hill">W D Hill</name>
<name sortKey="Huffman, J" sort="Huffman, J" uniqKey="Huffman J" first="J" last="Huffman">J. Huffman</name>
<name sortKey="Kirin, M" sort="Kirin, M" uniqKey="Kirin M" first="M" last="Kirin">M. Kirin</name>
<name sortKey="Liewald, D C" sort="Liewald, D C" uniqKey="Liewald D" first="D C" last="Liewald">D C Liewald</name>
<name sortKey="Luciano, M" sort="Luciano, M" uniqKey="Luciano M" first="M" last="Luciano">M. Luciano</name>
<name sortKey="Luciano, M" sort="Luciano, M" uniqKey="Luciano M" first="M" last="Luciano">M. Luciano</name>
<name sortKey="Marioni, R E" sort="Marioni, R E" uniqKey="Marioni R" first="R E" last="Marioni">R E Marioni</name>
<name sortKey="Marioni, R E" sort="Marioni, R E" uniqKey="Marioni R" first="R E" last="Marioni">R E Marioni</name>
<name sortKey="Palotie, A" sort="Palotie, A" uniqKey="Palotie A" first="A" last="Palotie">A. Palotie</name>
<name sortKey="Pattie, A" sort="Pattie, A" uniqKey="Pattie A" first="A" last="Pattie">A. Pattie</name>
<name sortKey="Porteous, D J" sort="Porteous, D J" uniqKey="Porteous D" first="D J" last="Porteous">D J Porteous</name>
<name sortKey="Porteous, D J" sort="Porteous, D J" uniqKey="Porteous D" first="D J" last="Porteous">D J Porteous</name>
<name sortKey="Porteous, D J" sort="Porteous, D J" uniqKey="Porteous D" first="D J" last="Porteous">D J Porteous</name>
<name sortKey="Redmond, P" sort="Redmond, P" uniqKey="Redmond P" first="P" last="Redmond">P. Redmond</name>
<name sortKey="Rudan, I" sort="Rudan, I" uniqKey="Rudan I" first="I" last="Rudan">I. Rudan</name>
<name sortKey="Scotland, Generation" sort="Scotland, Generation" uniqKey="Scotland G" first="Generation" last="Scotland">Generation Scotland</name>
<name sortKey="Starr, J M" sort="Starr, J M" uniqKey="Starr J" first="J M" last="Starr">J M Starr</name>
<name sortKey="Starr, J M" sort="Starr, J M" uniqKey="Starr J" first="J M" last="Starr">J M Starr</name>
<name sortKey="Stott, D J" sort="Stott, D J" uniqKey="Stott D" first="D J" last="Stott">D J Stott</name>
<name sortKey="Vitart, V" sort="Vitart, V" uniqKey="Vitart V" first="V" last="Vitart">V. Vitart</name>
<name sortKey="Wilson, J F" sort="Wilson, J F" uniqKey="Wilson J" first="J F" last="Wilson">J F Wilson</name>
<name sortKey="Wright, A F" sort="Wright, A F" uniqKey="Wright A" first="A F" last="Wright">A F Wright</name>
</country>
<country name="Australie">
<noRegion>
<name sortKey="Armstrong, N" sort="Armstrong, N" uniqKey="Armstrong N" first="N" last="Armstrong">N. Armstrong</name>
</noRegion>
<name sortKey="Ames, D" sort="Ames, D" uniqKey="Ames D" first="D" last="Ames">D. Ames</name>
<name sortKey="Ames, D" sort="Ames, D" uniqKey="Ames D" first="D" last="Ames">D. Ames</name>
<name sortKey="Assareh, A A" sort="Assareh, A A" uniqKey="Assareh A" first="A A" last="Assareh">A A Assareh</name>
<name sortKey="Attia, J R" sort="Attia, J R" uniqKey="Attia J" first="J R" last="Attia">J R Attia</name>
<name sortKey="Brodaty, H" sort="Brodaty, H" uniqKey="Brodaty H" first="H" last="Brodaty">H. Brodaty</name>
<name sortKey="Brodaty, H" sort="Brodaty, H" uniqKey="Brodaty H" first="H" last="Brodaty">H. Brodaty</name>
<name sortKey="Holliday, E G" sort="Holliday, E G" uniqKey="Holliday E" first="E G" last="Holliday">E G Holliday</name>
<name sortKey="Kochan, N" sort="Kochan, N" uniqKey="Kochan N" first="N" last="Kochan">N. Kochan</name>
<name sortKey="Kochan, N" sort="Kochan, N" uniqKey="Kochan N" first="N" last="Kochan">N. Kochan</name>
<name sortKey="Kwok, J B" sort="Kwok, J B" uniqKey="Kwok J" first="J B" last="Kwok">J B Kwok</name>
<name sortKey="Kwok, J B" sort="Kwok, J B" uniqKey="Kwok J" first="J B" last="Kwok">J B Kwok</name>
<name sortKey="Lee, T" sort="Lee, T" uniqKey="Lee T" first="T" last="Lee">T. Lee</name>
<name sortKey="Lee, T" sort="Lee, T" uniqKey="Lee T" first="T" last="Lee">T. Lee</name>
<name sortKey="Marioni, R E" sort="Marioni, R E" uniqKey="Marioni R" first="R E" last="Marioni">R E Marioni</name>
<name sortKey="Mather, K A" sort="Mather, K A" uniqKey="Mather K" first="K A" last="Mather">K A Mather</name>
<name sortKey="Oldmeadow, C" sort="Oldmeadow, C" uniqKey="Oldmeadow C" first="C" last="Oldmeadow">C. Oldmeadow</name>
<name sortKey="Reppermund, S" sort="Reppermund, S" uniqKey="Reppermund S" first="S" last="Reppermund">S. Reppermund</name>
<name sortKey="Sachdev, P S" sort="Sachdev, P S" uniqKey="Sachdev P" first="P S" last="Sachdev">P S Sachdev</name>
<name sortKey="Sachdev, P S" sort="Sachdev, P S" uniqKey="Sachdev P" first="P S" last="Sachdev">P S Sachdev</name>
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