The MTL1 Pentatricopeptide Repeat Protein Is Required for Both Translation and Splicing of the Mitochondrial NADH DEHYDROGENASE SUBUNIT7 mRNA in Arabidopsis1
Identifieur interne : 000C82 ( Pmc/Checkpoint ); précédent : 000C81; suivant : 000C83The MTL1 Pentatricopeptide Repeat Protein Is Required for Both Translation and Splicing of the Mitochondrial NADH DEHYDROGENASE SUBUNIT7 mRNA in Arabidopsis1
Auteurs : Nawel Haïli ; Noelya Planchard ; Nadège Arnal ; Martine Quadrado ; Nathalie Vrielynck ; Jennifer Dahan ; Catherine Colas Des Francs-Small ; Hakim MireauSource :
- Plant Physiology [ 0032-0889 ] ; 2015.
Abstract
A mitochondria-targeted pentatricopeptide repeat protein specifically facilitates the translation of a respiratory chain transcript without inducing any cleavage in its upstream noncoding region.
Url:
DOI: 10.1104/pp.15.01591
PubMed: 26537562
PubMed Central: 4704600
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Plant Physiol</journal-id><journal-id journal-id-type="iso-abbrev">Plant Physiol</journal-id><journal-id journal-id-type="hwp">plantphysiol</journal-id><journal-id journal-id-type="publisher-id">aspb</journal-id><journal-title-group><journal-title>Plant Physiology</journal-title></journal-title-group><issn pub-type="ppub">0032-0889</issn><issn pub-type="epub">1532-2548</issn><publisher><publisher-name>American Society of Plant Biologists</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26537562</article-id><article-id pub-id-type="pmc">4704600</article-id><article-id pub-id-type="publisher-id">PP201501591DR1</article-id><article-id pub-id-type="doi">10.1104/pp.15.01591</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject><subj-group subj-group-type="heading"><subject>Genes, Development and Evolution</subject></subj-group></subj-group></article-categories><title-group><article-title>The MTL1 Pentatricopeptide Repeat Protein Is Required for Both Translation and Splicing of the Mitochondrial <italic>NADH DEHYDROGENASE SUBUNIT7</italic> mRNA in Arabidopsis<xref ref-type="fn" rid="fn1"><sup>1</sup></xref></article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Haïli</surname><given-names>Nawel</given-names></name></contrib><contrib contrib-type="author"><name><surname>Planchard</surname><given-names>Noelya</given-names></name></contrib><contrib contrib-type="author"><name><surname>Arnal</surname><given-names>Nadège</given-names></name><xref ref-type="author-notes" rid="afn1"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Quadrado</surname><given-names>Martine</given-names></name></contrib><contrib contrib-type="author"><name><surname>Vrielynck</surname><given-names>Nathalie</given-names></name></contrib><contrib contrib-type="author"><name><surname>Dahan</surname><given-names>Jennifer</given-names></name><xref ref-type="author-notes" rid="afn2"><sup>3</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-6386-5672</contrib-id><name><surname>des Francs-Small</surname><given-names>Catherine Colas</given-names></name></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-2299-5139</contrib-id><name><surname>Mireau</surname><given-names>Hakim</given-names></name><xref ref-type="corresp" rid="cor1">*</xref></contrib><aff id="aff1">Institut Jean-Pierre Bourgin, Institut National de la Recherche Agronomique, AgroParisTech, Centre National de la Recherche Scientifique, Université Paris-Saclay, 78026 Versailles cedex, France (N.H., N.P., N.A., M.Q., N.V., J.D., H.M.);</aff><aff id="aff2">Université Paris-Sud, Université Paris-Saclay, 91405 Orsay cedex, France (N.H., N.P.); and</aff><aff id="aff3">Australian Research Council Centre of Excellence in Plant Energy Biology, University of Western Australia, Crawley, Western Australia 6009, Australia (C.C.d.F.-S.)</aff></contrib-group><author-notes><fn><p><ext-link ext-link-type="uri" xlink:href="http://www.plantphysiol.org/cgi/doi/10.1104/pp.15.01591">www.plantphysiol.org/cgi/doi/10.1104/pp.15.01591</ext-link></p></fn><fn id="afn1" fn-type="present-address"><label>2</label><p>Present address: Institut National de la Recherche Agronomique, Centre National de Ressources Génomiques Végétales, 31326 Castanet Tolosan, France.</p></fn><fn id="afn2" fn-type="present-address"><label>3</label><p>Present address: Department of Plant, Soil, and Entomological Sciences, University of Idaho, Moscow, ID 83844.</p></fn><corresp id="cor1"><label>*</label>Address correspondence to <email>hakim.mireau@versailles.inra.fr</email>.</corresp><fn id="afn3"><p>The author responsible for distribution of materials integral to the findings presented in this article in accordance with the policy described in the Instructions for Authors (<ext-link ext-link-type="uri" xlink:href="http://www.plantphysiol.org">www.plantphysiol.org</ext-link>) is: Hakim Mireau (<email>hakim.mireau@versailles.inra.fr</email>).</p></fn><fn id="afn4"><p>N.H. performed most of the experiments; N.P. performed part of the experiments; J.D. performed part of the experiments; C.C.d.F.-S. performed part of the experiments; N.A. provided technical assistance to N.H. and J.D.; M.Q. provided technical assistance to N.H., J.D., and N.P.; H.M. conceived the project, supervised the experiments, and wrote the article with contributions of all the authors.</p></fn></author-notes><pmc-comment>Fake ppub date generated by PMC from publisher
pub-date/@pub-type='epub-ppub' </pmc-comment>
<pub-date pub-type="ppub"><month>1</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>4</day><month>11</month><year>2015</year></pub-date><volume>170</volume><issue>1</issue><fpage>354</fpage><lpage>366</lpage><history><date date-type="received"><day>08</day><month>10</month><year>2015</year></date><date date-type="accepted"><day>03</day><month>11</month><year>2015</year></date></history><permissions><copyright-statement>© 2016 American Society of Plant Biologists. All Rights Reserved.</copyright-statement><copyright-year>2016</copyright-year></permissions><self-uri xlink:role="icon" xlink:href="PP_PP201501591DR1_ic1.gif"></self-uri><abstract abstract-type="precis"><p>A mitochondria-targeted pentatricopeptide repeat protein specifically facilitates the translation of a respiratory chain transcript without inducing any cleavage in its upstream noncoding region.</p></abstract><abstract><p>Mitochondrial translation involves a complex interplay of ancient bacteria-like features and host-derived functionalities. Although the basic components of the mitochondrial translation apparatus have been recognized, very few protein factors aiding in recruiting ribosomes on mitochondria-encoded messenger RNA (mRNAs) have been identified in higher plants. In this study, we describe the identification of the Arabidopsis (<italic>Arabidopsis thaliana</italic>) MITOCHONDRIAL TRANSLATION FACTOR1 (MTL1) protein, a new member of the Pentatricopeptide Repeat family, and show that it is essential for the translation of the mitochondrial <italic>NADH dehydrogenase subunit7</italic> (<italic>nad7</italic>) mRNA. We demonstrate that <italic>mtl1</italic> mutant plants fail to accumulate the Nad7 protein, even though the <italic>nad7</italic> mature mRNA is produced and bears the same 5′ and 3′ extremities as in wild-type plants. We next observed that polysome association of <italic>nad7</italic> mature mRNA is specifically disrupted in <italic>mtl1</italic> mutants, indicating that the absence of Nad7 results from a lack of translation of <italic>nad7</italic> mRNA. These findings illustrate that mitochondrial translation requires the intervention of gene-specific nucleus-encoded PPR trans-factors and that their action does not necessarily involve the 5′ processing of their target mRNA, as observed previously. Interestingly, a partial decrease in <italic>nad7</italic> intron 2 splicing was also detected in <italic>mtl1</italic> mutants, suggesting that MTL1 is also involved in group II intron splicing. However, this second function appears to be less essential for <italic>nad7</italic> expression than its role in translation. MTL1 will be instrumental to understand the multifunctionality of PPR proteins and the mechanisms governing mRNA translation and intron splicing in plant mitochondria.</p></abstract><counts><fig-count count="5"></fig-count><table-count count="0"></table-count><equation-count count="0"></equation-count><ref-count count="61"></ref-count><page-count count="13"></page-count></counts><custom-meta-group><custom-meta><meta-name> DJS Export </meta-name><meta-value>v1</meta-value></custom-meta></custom-meta-group></article-meta><notes><glossary><title>Glossary</title><def-list><def-item><term id="term1">SD</term><def id="def1"><p>Shine and Dalgarno</p></def></def-item><def-item><term id="term2">T-DNA</term><def id="def2"><p>transfer DNA</p></def></def-item><def-item><term id="term3">RT</term><def id="def3"><p>reverse transcription</p></def></def-item><def-item><term id="term4">Col-0</term><def id="def4"><p>Columbia-0</p></def></def-item><def-item><term id="term5">cDNA</term><def id="def5"><p>complementary DNA</p></def></def-item></def-list></glossary></notes></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Arnal, Nadege" sort="Arnal, Nadege" uniqKey="Arnal N" first="Nadège" last="Arnal">Nadège Arnal</name><name sortKey="Dahan, Jennifer" sort="Dahan, Jennifer" uniqKey="Dahan J" first="Jennifer" last="Dahan">Jennifer Dahan</name><name sortKey="Des Francs Small, Catherine Colas" sort="Des Francs Small, Catherine Colas" uniqKey="Des Francs Small C" first="Catherine Colas" last="Des Francs-Small">Catherine Colas Des Francs-Small</name><name sortKey="Haili, Nawel" sort="Haili, Nawel" uniqKey="Haili N" first="Nawel" last="Haïli">Nawel Haïli</name><name sortKey="Mireau, Hakim" sort="Mireau, Hakim" uniqKey="Mireau H" first="Hakim" last="Mireau">Hakim Mireau</name><name sortKey="Planchard, Noelya" sort="Planchard, Noelya" uniqKey="Planchard N" first="Noelya" last="Planchard">Noelya Planchard</name><name sortKey="Quadrado, Martine" sort="Quadrado, Martine" uniqKey="Quadrado M" first="Martine" last="Quadrado">Martine Quadrado</name><name sortKey="Vrielynck, Nathalie" sort="Vrielynck, Nathalie" uniqKey="Vrielynck N" first="Nathalie" last="Vrielynck">Nathalie Vrielynck</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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