LIN28B is over-expressed in specific subtypes of pediatric leukemia and regulates lncRNA H19
Identifieur interne : 000B97 ( Pmc/Checkpoint ); précédent : 000B96; suivant : 000B98LIN28B is over-expressed in specific subtypes of pediatric leukemia and regulates lncRNA H19
Auteurs : Hetty H. Helsmoortel [Belgique] ; Barbara De Moerloose [Belgique] ; Tim Pieters [Belgique] ; Farzaneh Ghazavi [Belgique] ; Silvia Bresolin [Italie] ; Hélène Cavé [France] ; Andrica De Vries [Pays-Bas] ; Valerie De Haas [Pays-Bas] ; Christian Flotho [Allemagne] ; Veerle Labarque [Belgique] ; Charlotte Niemeyer [Allemagne] ; Pascale De Paepe [Belgique] ; Nadine Van Roy [Belgique] ; Jan Stary [République tchèque] ; Marry M. Van Den Heuvel-Eibrink [Pays-Bas] ; Yves Benoit [Belgique] ; Johannes Schulte [Allemagne] ; Steven Goossens [Belgique] ; Geert Berx [Belgique] ; Jody J. Haigh [Australie] ; Frank Speleman [Belgique] ; Pieter Van Vlierberghe [Belgique] ; Tim Lammens [Belgique]Source :
- Haematologica [ 0390-6078 ] ; 2016.
Url:
DOI: 10.3324/haematol.2016.143818
PubMed: 26969084
PubMed Central: 5013963
Affiliations:
- Allemagne, Australie, Belgique, France, Italie, Pays-Bas, République tchèque
- Bade-Wurtemberg, Bohême centrale, District de Karlsruhe, Hollande-Méridionale, Province de Flandre-Orientale, Région flamande, Utrecht (province), Île-de-France
- Gand, Heidelberg, Paris, Prague, Rotterdam, Utrecht
- Université de Gand
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xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University</wicri:regionArea><placeName><settlement type="city">Gand</settlement><region>Région flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName><orgName type="university">Université de Gand</orgName></affiliation></author><author><name sortKey="Bresolin, Silvia" sort="Bresolin, Silvia" uniqKey="Bresolin S" first="Silvia" last="Bresolin">Silvia Bresolin</name><affiliation wicri:level="1"><nlm:aff id="af5-101e240">Department of Women and Child Health, University of Padova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Women and Child Health, University of Padova</wicri:regionArea><wicri:noRegion>University of Padova</wicri:noRegion></affiliation></author><author><name sortKey="Cave, Helene" sort="Cave, Helene" uniqKey="Cave H" first="Hélène" last="Cavé">Hélène Cavé</name><affiliation wicri:level="3"><nlm:aff id="af6-101e240">Department of Genetics, University Hospital of Robert Debré and Paris-Diderot University, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Genetics, University Hospital of Robert Debré and Paris-Diderot University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="De Vries, Andrica" sort="De Vries, Andrica" uniqKey="De Vries A" first="Andrica" last="De Vries">Andrica De Vries</name><affiliation wicri:level="3"><nlm:aff id="af7-101e240">Department of Paediatric Oncology/Haematology, Erasmus MC-Sophia Children’s Hospital, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Paediatric Oncology/Haematology, Erasmus MC-Sophia Children’s Hospital, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="De Haas, Valerie" sort="De Haas, Valerie" uniqKey="De Haas V" first="Valerie" last="De Haas">Valerie De Haas</name><affiliation wicri:level="1"><nlm:aff id="af8-101e240">Dutch Childhood Oncology Group (DCOG), the Hague, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Dutch Childhood Oncology Group (DCOG), the Hague</wicri:regionArea><wicri:noRegion>the Hague</wicri:noRegion></affiliation></author><author><name sortKey="Flotho, Christian" sort="Flotho, Christian" uniqKey="Flotho C" first="Christian" last="Flotho">Christian Flotho</name><affiliation wicri:level="1"><nlm:aff id="af9-101e240">Department of Paediatrics and Adolescent Medicine, Division of Paediatric Haematology and Oncology, University of Freiburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Paediatrics and Adolescent Medicine, Division of Paediatric Haematology and Oncology, University of Freiburg</wicri:regionArea><wicri:noRegion>University of Freiburg</wicri:noRegion><wicri:noRegion>University of Freiburg</wicri:noRegion><wicri:noRegion>University of Freiburg</wicri:noRegion></affiliation></author><author><name sortKey="Labarque, Veerle" sort="Labarque, Veerle" uniqKey="Labarque V" first="Veerle" last="Labarque">Veerle Labarque</name><affiliation wicri:level="1"><nlm:aff id="af10-101e240">Pediatric Haemato-Oncology, University Hospitals Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Pediatric Haemato-Oncology, University Hospitals Leuven</wicri:regionArea><wicri:noRegion>University Hospitals Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Niemeyer, Charlotte" sort="Niemeyer, Charlotte" uniqKey="Niemeyer C" first="Charlotte" last="Niemeyer">Charlotte Niemeyer</name><affiliation wicri:level="1"><nlm:aff id="af9-101e240">Department of Paediatrics and Adolescent Medicine, Division of Paediatric Haematology and Oncology, University of Freiburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Paediatrics and Adolescent Medicine, Division of Paediatric Haematology and Oncology, University of Freiburg</wicri:regionArea><wicri:noRegion>University of Freiburg</wicri:noRegion><wicri:noRegion>University of Freiburg</wicri:noRegion><wicri:noRegion>University of Freiburg</wicri:noRegion></affiliation></author><author><name sortKey="De Paepe, Pascale" sort="De Paepe, Pascale" uniqKey="De Paepe P" first="Pascale" last="De Paepe">Pascale De Paepe</name><affiliation wicri:level="1"><nlm:aff id="af11-101e240">Pathological Anatomy, AZ Sint Jan Bruges, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Pathological Anatomy, AZ Sint Jan Bruges</wicri:regionArea><wicri:noRegion>AZ Sint Jan Bruges</wicri:noRegion></affiliation></author><author><name sortKey="Van Roy, Nadine" sort="Van Roy, Nadine" uniqKey="Van Roy N" first="Nadine" last="Van Roy">Nadine Van Roy</name><affiliation wicri:level="4"><nlm:aff id="af2-101e240">Center for Medical Genetics, Ghent University, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University</wicri:regionArea><placeName><settlement type="city">Gand</settlement><region>Région flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName><orgName type="university">Université de Gand</orgName></affiliation></author><author><name sortKey="Stary, Jan" sort="Stary, Jan" uniqKey="Stary J" first="Jan" last="Stary">Jan Stary</name><affiliation wicri:level="3"><nlm:aff id="af12-101e240">Department of Paediatric Haematology/Oncology, Charles University and University Hospital Motol, Prague, Czech Republic</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Paediatric Haematology/Oncology, Charles University and University Hospital Motol, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Van Den Heuvel Eibrink, Marry M" sort="Van Den Heuvel Eibrink, Marry M" uniqKey="Van Den Heuvel Eibrink M" first="Marry M." last="Van Den Heuvel-Eibrink">Marry M. Van Den Heuvel-Eibrink</name><affiliation wicri:level="1"><nlm:aff id="af8-101e240">Dutch Childhood Oncology Group (DCOG), the Hague, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Dutch Childhood Oncology Group (DCOG), the Hague</wicri:regionArea><wicri:noRegion>the Hague</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="af13-101e240">Princess Maxima Center for Paediatric Oncology, Utrecht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Princess Maxima Center for Paediatric Oncology, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Benoit, Yves" sort="Benoit, Yves" uniqKey="Benoit Y" first="Yves" last="Benoit">Yves Benoit</name><affiliation wicri:level="1"><nlm:aff id="af1-101e240">Department of Paediatric Haematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Paediatric Haematology-Oncology and Stem Cell Transplantation, Ghent University Hospital</wicri:regionArea><wicri:noRegion>Ghent University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Schulte, Johannes" sort="Schulte, Johannes" uniqKey="Schulte J" first="Johannes" last="Schulte">Johannes Schulte</name><affiliation wicri:level="3"><nlm:aff id="af14-101e240">Division of Neuroblastoma Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Neuroblastoma Genomics, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="af15-101e240">Department of Paediatric Oncology and Haematology, University Children’s Hospital Essen, Essen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Paediatric Oncology and Haematology, University Children’s Hospital Essen, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af16-101e240">German Consortium for Translational Cancer Research (DKTK), Essen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Consortium for Translational Cancer Research (DKTK), Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af17-101e240">Translational Neuro-Oncology, West German Cancer Center (WTZ), University Hospital Essen, University Duisburg-Essen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Translational Neuro-Oncology, West German Cancer Center (WTZ), University Hospital Essen, University Duisburg-Essen</wicri:regionArea><wicri:noRegion>University Duisburg-Essen</wicri:noRegion><wicri:noRegion>University Duisburg-Essen</wicri:noRegion><wicri:noRegion>University Duisburg-Essen</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af18-101e240">Centre for Medical Biotechnology, University Duisburg-Essen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Centre for Medical Biotechnology, University Duisburg-Essen</wicri:regionArea><wicri:noRegion>University Duisburg-Essen</wicri:noRegion><wicri:noRegion>University Duisburg-Essen</wicri:noRegion><wicri:noRegion>University Duisburg-Essen</wicri:noRegion></affiliation></author><author><name sortKey="Goossens, Steven" sort="Goossens, Steven" uniqKey="Goossens S" first="Steven" last="Goossens">Steven Goossens</name><affiliation wicri:level="4"><nlm:aff id="af3-101e240">Unit for Molecular and Cellular Oncology, VIB Inflammation Research Center, Ghent University, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Unit for Molecular and Cellular Oncology, VIB Inflammation Research Center, Ghent University</wicri:regionArea><placeName><settlement type="city">Gand</settlement><region>Région flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName><orgName type="university">Université de Gand</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="af4-101e240">Department of Biomedical Molecular Biology, Ghent University, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Biomedical Molecular Biology, Ghent University</wicri:regionArea><placeName><settlement type="city">Gand</settlement><region>Région flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName><orgName type="university">Université de Gand</orgName></affiliation></author><author><name sortKey="Berx, Geert" sort="Berx, Geert" uniqKey="Berx G" first="Geert" last="Berx">Geert Berx</name><affiliation wicri:level="4"><nlm:aff id="af3-101e240">Unit for Molecular and Cellular Oncology, VIB Inflammation Research Center, Ghent University, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Unit for Molecular and Cellular Oncology, VIB Inflammation Research Center, Ghent University</wicri:regionArea><placeName><settlement type="city">Gand</settlement><region>Région flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName><orgName type="university">Université de Gand</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="af4-101e240">Department of Biomedical Molecular Biology, Ghent University, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Biomedical Molecular Biology, Ghent University</wicri:regionArea><placeName><settlement type="city">Gand</settlement><region>Région flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName><orgName type="university">Université de Gand</orgName></affiliation></author><author><name sortKey="Haigh, Jody J" sort="Haigh, Jody J" uniqKey="Haigh J" first="Jody J." last="Haigh">Jody J. Haigh</name><affiliation wicri:level="1"><nlm:aff id="af19-101e240">Mammalian Functional Genetics Laboratory, Division of Blood Cancers, Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Mammalian Functional Genetics Laboratory, Division of Blood Cancers, Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Speleman, Frank" sort="Speleman, Frank" uniqKey="Speleman F" first="Frank" last="Speleman">Frank Speleman</name><affiliation wicri:level="4"><nlm:aff id="af2-101e240">Center for Medical Genetics, Ghent University, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University</wicri:regionArea><placeName><settlement type="city">Gand</settlement><region>Région flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName><orgName type="university">Université de Gand</orgName></affiliation></author><author><name sortKey="Van Vlierberghe, Pieter" sort="Van Vlierberghe, Pieter" uniqKey="Van Vlierberghe P" first="Pieter" last="Van Vlierberghe">Pieter Van Vlierberghe</name><affiliation wicri:level="4"><nlm:aff id="af2-101e240">Center for Medical Genetics, Ghent University, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University</wicri:regionArea><placeName><settlement type="city">Gand</settlement><region>Région flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName><orgName type="university">Université de Gand</orgName></affiliation></author><author><name sortKey="Lammens, Tim" sort="Lammens, Tim" uniqKey="Lammens T" first="Tim" last="Lammens">Tim Lammens</name><affiliation wicri:level="1"><nlm:aff id="af1-101e240">Department of Paediatric Haematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Paediatric Haematology-Oncology and Stem Cell Transplantation, Ghent University Hospital</wicri:regionArea><wicri:noRegion>Ghent University Hospital</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26969084</idno><idno type="pmc">5013963</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013963</idno><idno type="RBID">PMC:5013963</idno><idno type="doi">10.3324/haematol.2016.143818</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">001306</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001306</idno><idno type="wicri:Area/Pmc/Curation">001166</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001166</idno><idno type="wicri:Area/Pmc/Checkpoint">000B97</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000B97</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>LIN28B</italic> is over-expressed in specific subtypes of pediatric leukemia and regulates lncRNA <italic>H19</italic></title><author><name sortKey="Helsmoortel, Hetty H" sort="Helsmoortel, Hetty H" uniqKey="Helsmoortel H" first="Hetty H." last="Helsmoortel">Hetty H. Helsmoortel</name><affiliation wicri:level="1"><nlm:aff id="af1-101e240">Department of Paediatric Haematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Paediatric Haematology-Oncology and Stem Cell Transplantation, Ghent University Hospital</wicri:regionArea><wicri:noRegion>Ghent University Hospital</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="af2-101e240">Center for Medical Genetics, Ghent University, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University</wicri:regionArea><placeName><settlement type="city">Gand</settlement><region>Région flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName><orgName type="university">Université de Gand</orgName></affiliation></author><author><name sortKey="De Moerloose, Barbara" sort="De Moerloose, Barbara" uniqKey="De Moerloose B" first="Barbara" last="De Moerloose">Barbara De Moerloose</name><affiliation wicri:level="1"><nlm:aff id="af1-101e240">Department of Paediatric Haematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Paediatric Haematology-Oncology and Stem Cell Transplantation, Ghent University Hospital</wicri:regionArea><wicri:noRegion>Ghent University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Pieters, Tim" sort="Pieters, Tim" uniqKey="Pieters T" first="Tim" last="Pieters">Tim Pieters</name><affiliation wicri:level="4"><nlm:aff id="af2-101e240">Center for Medical Genetics, Ghent University, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University</wicri:regionArea><placeName><settlement type="city">Gand</settlement><region>Région flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName><orgName type="university">Université de Gand</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="af3-101e240">Unit for Molecular and Cellular Oncology, VIB Inflammation Research Center, Ghent University, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Unit for Molecular and Cellular Oncology, VIB Inflammation Research Center, Ghent University</wicri:regionArea><placeName><settlement type="city">Gand</settlement><region>Région flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName><orgName type="university">Université de Gand</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="af4-101e240">Department of Biomedical Molecular Biology, Ghent University, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Biomedical Molecular Biology, Ghent University</wicri:regionArea><placeName><settlement type="city">Gand</settlement><region>Région flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName><orgName type="university">Université de Gand</orgName></affiliation></author><author><name sortKey="Ghazavi, Farzaneh" sort="Ghazavi, Farzaneh" uniqKey="Ghazavi F" first="Farzaneh" last="Ghazavi">Farzaneh Ghazavi</name><affiliation wicri:level="1"><nlm:aff id="af1-101e240">Department of Paediatric Haematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Paediatric Haematology-Oncology and Stem Cell Transplantation, Ghent University Hospital</wicri:regionArea><wicri:noRegion>Ghent University Hospital</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="af2-101e240">Center for Medical Genetics, Ghent University, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University</wicri:regionArea><placeName><settlement type="city">Gand</settlement><region>Région flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName><orgName type="university">Université de Gand</orgName></affiliation></author><author><name sortKey="Bresolin, Silvia" sort="Bresolin, Silvia" uniqKey="Bresolin S" first="Silvia" last="Bresolin">Silvia Bresolin</name><affiliation wicri:level="1"><nlm:aff id="af5-101e240">Department of Women and Child Health, University of Padova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Women and Child Health, University of Padova</wicri:regionArea><wicri:noRegion>University of Padova</wicri:noRegion></affiliation></author><author><name sortKey="Cave, Helene" sort="Cave, Helene" uniqKey="Cave H" first="Hélène" last="Cavé">Hélène Cavé</name><affiliation wicri:level="3"><nlm:aff id="af6-101e240">Department of Genetics, University Hospital of Robert Debré and Paris-Diderot University, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Genetics, University Hospital of Robert Debré and Paris-Diderot University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="De Vries, Andrica" sort="De Vries, Andrica" uniqKey="De Vries A" first="Andrica" last="De Vries">Andrica De Vries</name><affiliation wicri:level="3"><nlm:aff id="af7-101e240">Department of Paediatric Oncology/Haematology, Erasmus MC-Sophia Children’s Hospital, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Paediatric Oncology/Haematology, Erasmus MC-Sophia Children’s Hospital, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="De Haas, Valerie" sort="De Haas, Valerie" uniqKey="De Haas V" first="Valerie" last="De Haas">Valerie De Haas</name><affiliation wicri:level="1"><nlm:aff id="af8-101e240">Dutch Childhood Oncology Group (DCOG), the Hague, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Dutch Childhood Oncology Group (DCOG), the Hague</wicri:regionArea><wicri:noRegion>the Hague</wicri:noRegion></affiliation></author><author><name sortKey="Flotho, Christian" sort="Flotho, Christian" uniqKey="Flotho C" first="Christian" last="Flotho">Christian Flotho</name><affiliation wicri:level="1"><nlm:aff id="af9-101e240">Department of Paediatrics and Adolescent Medicine, Division of Paediatric Haematology and Oncology, University of Freiburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Paediatrics and Adolescent Medicine, Division of Paediatric Haematology and Oncology, University of Freiburg</wicri:regionArea><wicri:noRegion>University of Freiburg</wicri:noRegion><wicri:noRegion>University of Freiburg</wicri:noRegion><wicri:noRegion>University of Freiburg</wicri:noRegion></affiliation></author><author><name sortKey="Labarque, Veerle" sort="Labarque, Veerle" uniqKey="Labarque V" first="Veerle" last="Labarque">Veerle Labarque</name><affiliation wicri:level="1"><nlm:aff id="af10-101e240">Pediatric Haemato-Oncology, University Hospitals Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Pediatric Haemato-Oncology, University Hospitals Leuven</wicri:regionArea><wicri:noRegion>University Hospitals Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Niemeyer, Charlotte" sort="Niemeyer, Charlotte" uniqKey="Niemeyer C" first="Charlotte" last="Niemeyer">Charlotte Niemeyer</name><affiliation wicri:level="1"><nlm:aff id="af9-101e240">Department of Paediatrics and Adolescent Medicine, Division of Paediatric Haematology and Oncology, University of Freiburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Paediatrics and Adolescent Medicine, Division of Paediatric Haematology and Oncology, University of Freiburg</wicri:regionArea><wicri:noRegion>University of Freiburg</wicri:noRegion><wicri:noRegion>University of Freiburg</wicri:noRegion><wicri:noRegion>University of Freiburg</wicri:noRegion></affiliation></author><author><name sortKey="De Paepe, Pascale" sort="De Paepe, Pascale" uniqKey="De Paepe P" first="Pascale" last="De Paepe">Pascale De Paepe</name><affiliation wicri:level="1"><nlm:aff id="af11-101e240">Pathological Anatomy, AZ Sint Jan Bruges, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Pathological Anatomy, AZ Sint Jan Bruges</wicri:regionArea><wicri:noRegion>AZ Sint Jan Bruges</wicri:noRegion></affiliation></author><author><name sortKey="Van Roy, Nadine" sort="Van Roy, Nadine" uniqKey="Van Roy N" first="Nadine" last="Van Roy">Nadine Van Roy</name><affiliation wicri:level="4"><nlm:aff id="af2-101e240">Center for Medical Genetics, Ghent University, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University</wicri:regionArea><placeName><settlement type="city">Gand</settlement><region>Région flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName><orgName type="university">Université de Gand</orgName></affiliation></author><author><name sortKey="Stary, Jan" sort="Stary, Jan" uniqKey="Stary J" first="Jan" last="Stary">Jan Stary</name><affiliation wicri:level="3"><nlm:aff id="af12-101e240">Department of Paediatric Haematology/Oncology, Charles University and University Hospital Motol, Prague, Czech Republic</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Paediatric Haematology/Oncology, Charles University and University Hospital Motol, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Van Den Heuvel Eibrink, Marry M" sort="Van Den Heuvel Eibrink, Marry M" uniqKey="Van Den Heuvel Eibrink M" first="Marry M." last="Van Den Heuvel-Eibrink">Marry M. Van Den Heuvel-Eibrink</name><affiliation wicri:level="1"><nlm:aff id="af8-101e240">Dutch Childhood Oncology Group (DCOG), the Hague, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Dutch Childhood Oncology Group (DCOG), the Hague</wicri:regionArea><wicri:noRegion>the Hague</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="af13-101e240">Princess Maxima Center for Paediatric Oncology, Utrecht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Princess Maxima Center for Paediatric Oncology, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Benoit, Yves" sort="Benoit, Yves" uniqKey="Benoit Y" first="Yves" last="Benoit">Yves Benoit</name><affiliation wicri:level="1"><nlm:aff id="af1-101e240">Department of Paediatric Haematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Paediatric Haematology-Oncology and Stem Cell Transplantation, Ghent University Hospital</wicri:regionArea><wicri:noRegion>Ghent University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Schulte, Johannes" sort="Schulte, Johannes" uniqKey="Schulte J" first="Johannes" last="Schulte">Johannes Schulte</name><affiliation wicri:level="3"><nlm:aff id="af14-101e240">Division of Neuroblastoma Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Neuroblastoma Genomics, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="af15-101e240">Department of Paediatric Oncology and Haematology, University Children’s Hospital Essen, Essen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Paediatric Oncology and Haematology, University Children’s Hospital Essen, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af16-101e240">German Consortium for Translational Cancer Research (DKTK), Essen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Consortium for Translational Cancer Research (DKTK), Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af17-101e240">Translational Neuro-Oncology, West German Cancer Center (WTZ), University Hospital Essen, University Duisburg-Essen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Translational Neuro-Oncology, West German Cancer Center (WTZ), University Hospital Essen, University Duisburg-Essen</wicri:regionArea><wicri:noRegion>University Duisburg-Essen</wicri:noRegion><wicri:noRegion>University Duisburg-Essen</wicri:noRegion><wicri:noRegion>University Duisburg-Essen</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af18-101e240">Centre for Medical Biotechnology, University Duisburg-Essen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Centre for Medical Biotechnology, University Duisburg-Essen</wicri:regionArea><wicri:noRegion>University Duisburg-Essen</wicri:noRegion><wicri:noRegion>University Duisburg-Essen</wicri:noRegion><wicri:noRegion>University Duisburg-Essen</wicri:noRegion></affiliation></author><author><name sortKey="Goossens, Steven" sort="Goossens, Steven" uniqKey="Goossens S" first="Steven" last="Goossens">Steven Goossens</name><affiliation wicri:level="4"><nlm:aff id="af3-101e240">Unit for Molecular and Cellular Oncology, VIB Inflammation Research Center, Ghent University, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Unit for Molecular and Cellular Oncology, VIB Inflammation Research Center, Ghent University</wicri:regionArea><placeName><settlement type="city">Gand</settlement><region>Région flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName><orgName type="university">Université de Gand</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="af4-101e240">Department of Biomedical Molecular Biology, Ghent University, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Biomedical Molecular Biology, Ghent University</wicri:regionArea><placeName><settlement type="city">Gand</settlement><region>Région flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName><orgName type="university">Université de Gand</orgName></affiliation></author><author><name sortKey="Berx, Geert" sort="Berx, Geert" uniqKey="Berx G" first="Geert" last="Berx">Geert Berx</name><affiliation wicri:level="4"><nlm:aff id="af3-101e240">Unit for Molecular and Cellular Oncology, VIB Inflammation Research Center, Ghent University, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Unit for Molecular and Cellular Oncology, VIB Inflammation Research Center, Ghent University</wicri:regionArea><placeName><settlement type="city">Gand</settlement><region>Région flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName><orgName type="university">Université de Gand</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="af4-101e240">Department of Biomedical Molecular Biology, Ghent University, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Biomedical Molecular Biology, Ghent University</wicri:regionArea><placeName><settlement type="city">Gand</settlement><region>Région flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName><orgName type="university">Université de Gand</orgName></affiliation></author><author><name sortKey="Haigh, Jody J" sort="Haigh, Jody J" uniqKey="Haigh J" first="Jody J." last="Haigh">Jody J. Haigh</name><affiliation wicri:level="1"><nlm:aff id="af19-101e240">Mammalian Functional Genetics Laboratory, Division of Blood Cancers, Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Mammalian Functional Genetics Laboratory, Division of Blood Cancers, Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Speleman, Frank" sort="Speleman, Frank" uniqKey="Speleman F" first="Frank" last="Speleman">Frank Speleman</name><affiliation wicri:level="4"><nlm:aff id="af2-101e240">Center for Medical Genetics, Ghent University, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University</wicri:regionArea><placeName><settlement type="city">Gand</settlement><region>Région flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName><orgName type="university">Université de Gand</orgName></affiliation></author><author><name sortKey="Van Vlierberghe, Pieter" sort="Van Vlierberghe, Pieter" uniqKey="Van Vlierberghe P" first="Pieter" last="Van Vlierberghe">Pieter Van Vlierberghe</name><affiliation wicri:level="4"><nlm:aff id="af2-101e240">Center for Medical Genetics, Ghent University, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University</wicri:regionArea><placeName><settlement type="city">Gand</settlement><region>Région flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName><orgName type="university">Université de Gand</orgName></affiliation></author><author><name sortKey="Lammens, Tim" sort="Lammens, Tim" uniqKey="Lammens T" first="Tim" last="Lammens">Tim Lammens</name><affiliation wicri:level="1"><nlm:aff id="af1-101e240">Department of Paediatric Haematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Paediatric Haematology-Oncology and Stem Cell Transplantation, Ghent University Hospital</wicri:regionArea><wicri:noRegion>Ghent University Hospital</wicri:noRegion></affiliation></author></analytic><series><title level="j">Haematologica</title><idno type="ISSN">0390-6078</idno><idno type="eISSN">1592-8721</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader></TEI><pmc article-type="letter"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Haematologica</journal-id><journal-id journal-id-type="iso-abbrev">Haematologica</journal-id><journal-id journal-id-type="hwp">haematol</journal-id><journal-id journal-id-type="publisher-id">Haematologica</journal-id><journal-title-group><journal-title>Haematologica</journal-title></journal-title-group><issn pub-type="ppub">0390-6078</issn><issn pub-type="epub">1592-8721</issn><publisher><publisher-name>Ferrata Storti Foundation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26969084</article-id><article-id pub-id-type="pmc">5013963</article-id><article-id pub-id-type="doi">10.3324/haematol.2016.143818</article-id><article-id pub-id-type="publisher-id">101e240</article-id><article-categories><subj-group subj-group-type="heading"><subject>Online Only Articles</subject></subj-group></article-categories><title-group><article-title><italic>LIN28B</italic> is over-expressed in specific subtypes of pediatric leukemia and regulates lncRNA <italic>H19</italic></article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Helsmoortel</surname><given-names>Hetty H.</given-names></name><xref ref-type="aff" rid="af1-101e240">1</xref><xref ref-type="aff" rid="af2-101e240">2</xref></contrib><contrib contrib-type="author"><name><surname>De Moerloose</surname><given-names>Barbara</given-names></name><xref ref-type="aff" rid="af1-101e240">1</xref></contrib><contrib contrib-type="author"><name><surname>Pieters</surname><given-names>Tim</given-names></name><xref ref-type="aff" rid="af2-101e240">2</xref><xref ref-type="aff" rid="af3-101e240">3</xref><xref ref-type="aff" rid="af4-101e240">4</xref></contrib><contrib contrib-type="author"><name><surname>Ghazavi</surname><given-names>Farzaneh</given-names></name><xref ref-type="aff" rid="af1-101e240">1</xref><xref ref-type="aff" rid="af2-101e240">2</xref></contrib><contrib contrib-type="author"><name><surname>Bresolin</surname><given-names>Silvia</given-names></name><xref ref-type="aff" rid="af5-101e240">5</xref></contrib><contrib contrib-type="author"><name><surname>Cavé</surname><given-names>Hélène</given-names></name><xref ref-type="aff" rid="af6-101e240">6</xref></contrib><contrib contrib-type="author"><name><surname>de Vries</surname><given-names>Andrica</given-names></name><xref ref-type="aff" rid="af7-101e240">7</xref></contrib><contrib contrib-type="author"><name><surname>de Haas</surname><given-names>Valerie</given-names></name><xref ref-type="aff" rid="af8-101e240">8</xref></contrib><contrib contrib-type="author"><name><surname>Flotho</surname><given-names>Christian</given-names></name><xref ref-type="aff" rid="af9-101e240">9</xref></contrib><contrib contrib-type="author"><name><surname>Labarque</surname><given-names>Veerle</given-names></name><xref ref-type="aff" rid="af10-101e240">10</xref></contrib><contrib contrib-type="author"><name><surname>Niemeyer</surname><given-names>Charlotte</given-names></name><xref ref-type="aff" rid="af9-101e240">9</xref></contrib><contrib contrib-type="author"><name><surname>De Paepe</surname><given-names>Pascale</given-names></name><xref ref-type="aff" rid="af11-101e240">11</xref></contrib><contrib contrib-type="author"><name><surname>Van Roy</surname><given-names>Nadine</given-names></name><xref ref-type="aff" rid="af2-101e240">2</xref></contrib><contrib contrib-type="author"><name><surname>Stary</surname><given-names>Jan</given-names></name><xref ref-type="aff" rid="af12-101e240">12</xref></contrib><contrib contrib-type="author"><name><surname>van den Heuvel-Eibrink</surname><given-names>Marry M.</given-names></name><xref ref-type="aff" rid="af8-101e240">8</xref><xref ref-type="aff" rid="af13-101e240">13</xref></contrib><contrib contrib-type="author"><name><surname>Benoit</surname><given-names>Yves</given-names></name><xref ref-type="aff" rid="af1-101e240">1</xref></contrib><contrib contrib-type="author"><name><surname>Schulte</surname><given-names>Johannes</given-names></name><xref ref-type="aff" rid="af14-101e240">14</xref><xref ref-type="aff" rid="af15-101e240">15</xref><xref ref-type="aff" rid="af16-101e240">16</xref><xref ref-type="aff" rid="af17-101e240">17</xref><xref ref-type="aff" rid="af18-101e240">18</xref></contrib><contrib contrib-type="author"><name><surname>Goossens</surname><given-names>Steven</given-names></name><xref ref-type="aff" rid="af3-101e240">3</xref><xref ref-type="aff" rid="af4-101e240">4</xref></contrib><contrib contrib-type="author"><name><surname>Berx</surname><given-names>Geert</given-names></name><xref ref-type="aff" rid="af3-101e240">3</xref><xref ref-type="aff" rid="af4-101e240">4</xref></contrib><contrib contrib-type="author"><name><surname>Haigh</surname><given-names>Jody J.</given-names></name><xref ref-type="aff" rid="af19-101e240">19</xref></contrib><contrib contrib-type="author"><name><surname>Speleman</surname><given-names>Frank</given-names></name><xref ref-type="aff" rid="af2-101e240">2</xref></contrib><contrib contrib-type="author"><name><surname>Van Vlierberghe</surname><given-names>Pieter</given-names></name><xref ref-type="aff" rid="af2-101e240">2</xref><xref ref-type="author-notes" rid="fn1-101e240">*</xref></contrib><contrib contrib-type="author"><name><surname>Lammens</surname><given-names>Tim</given-names></name><xref ref-type="aff" rid="af1-101e240">1</xref><xref ref-type="author-notes" rid="fn1-101e240">*</xref><xref ref-type="corresp" rid="c1-101e240"></xref></contrib></contrib-group><aff id="af1-101e240"><label>1</label>Department of Paediatric Haematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Belgium</aff><aff id="af2-101e240"><label>2</label>Center for Medical Genetics, Ghent University, Belgium</aff><aff id="af3-101e240"><label>3</label>Unit for Molecular and Cellular Oncology, VIB Inflammation Research Center, Ghent University, Belgium</aff><aff id="af4-101e240"><label>4</label>Department of Biomedical Molecular Biology, Ghent University, Belgium</aff><aff id="af5-101e240"><label>5</label>Department of Women and Child Health, University of Padova, Italy</aff><aff id="af6-101e240"><label>6</label>Department of Genetics, University Hospital of Robert Debré and Paris-Diderot University, Paris, France</aff><aff id="af7-101e240"><label>7</label>Department of Paediatric Oncology/Haematology, Erasmus MC-Sophia Children’s Hospital, Rotterdam, the Netherlands</aff><aff id="af8-101e240"><label>8</label>Dutch Childhood Oncology Group (DCOG), the Hague, the Netherlands</aff><aff id="af9-101e240"><label>9</label>Department of Paediatrics and Adolescent Medicine, Division of Paediatric Haematology and Oncology, University of Freiburg, Germany</aff><aff id="af10-101e240"><label>10</label>Pediatric Haemato-Oncology, University Hospitals Leuven, Belgium</aff><aff id="af11-101e240"><label>11</label>Pathological Anatomy, AZ Sint Jan Bruges, Belgium</aff><aff id="af12-101e240"><label>12</label>Department of Paediatric Haematology/Oncology, Charles University and University Hospital Motol, Prague, Czech Republic</aff><aff id="af13-101e240"><label>13</label>Princess Maxima Center for Paediatric Oncology, Utrecht, the Netherlands</aff><aff id="af14-101e240"><label>14</label>Division of Neuroblastoma Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="af15-101e240"><label>15</label>Department of Paediatric Oncology and Haematology, University Children’s Hospital Essen, Essen, Germany</aff><aff id="af16-101e240"><label>16</label>German Consortium for Translational Cancer Research (DKTK), Essen, Germany</aff><aff id="af17-101e240"><label>17</label>Translational Neuro-Oncology, West German Cancer Center (WTZ), University Hospital Essen, University Duisburg-Essen, Germany</aff><aff id="af18-101e240"><label>18</label>Centre for Medical Biotechnology, University Duisburg-Essen, Germany</aff><aff id="af19-101e240"><label>19</label>Mammalian Functional Genetics Laboratory, Division of Blood Cancers, Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia</aff><author-notes><corresp id="c1-101e240">Correspondence: <email>Tim.Lammens@UGent.be</email></corresp><fn id="fn1-101e240"><label>*</label><p>PVV and TL contributed equally to this work</p></fn></author-notes><pub-date pub-type="ppub"><month>6</month><year>2016</year></pub-date><volume>101</volume><issue>6</issue><fpage>e240</fpage><lpage>e244</lpage><permissions><copyright-statement>Copyright© Ferrata Storti Foundation</copyright-statement><copyright-year>2016</copyright-year></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="101e240.pdf"></self-uri><kwd-group><kwd>pediatric leukemia</kwd><kwd>LIN28B overexpression</kwd><kwd>IncRNA H19 regulation</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>République tchèque</li></country><region><li>Bade-Wurtemberg</li><li>Bohême centrale</li><li>District de Karlsruhe</li><li>Hollande-Méridionale</li><li>Province de Flandre-Orientale</li><li>Région flamande</li><li>Utrecht (province)</li><li>Île-de-France</li></region><settlement><li>Gand</li><li>Heidelberg</li><li>Paris</li><li>Prague</li><li>Rotterdam</li><li>Utrecht</li></settlement><orgName><li>Université de Gand</li></orgName></list><tree><country name="Belgique"><noRegion><name sortKey="Helsmoortel, Hetty H" sort="Helsmoortel, Hetty H" uniqKey="Helsmoortel H" first="Hetty H." last="Helsmoortel">Hetty H. Helsmoortel</name></noRegion><name sortKey="Benoit, Yves" sort="Benoit, Yves" uniqKey="Benoit Y" first="Yves" last="Benoit">Yves Benoit</name><name sortKey="Berx, Geert" sort="Berx, Geert" uniqKey="Berx G" first="Geert" last="Berx">Geert Berx</name><name sortKey="Berx, Geert" sort="Berx, Geert" uniqKey="Berx G" first="Geert" last="Berx">Geert Berx</name><name sortKey="De Moerloose, Barbara" sort="De Moerloose, Barbara" uniqKey="De Moerloose B" first="Barbara" last="De Moerloose">Barbara De Moerloose</name><name sortKey="De Paepe, Pascale" sort="De Paepe, Pascale" uniqKey="De Paepe P" first="Pascale" last="De Paepe">Pascale De Paepe</name><name sortKey="Ghazavi, Farzaneh" sort="Ghazavi, Farzaneh" uniqKey="Ghazavi F" first="Farzaneh" last="Ghazavi">Farzaneh Ghazavi</name><name sortKey="Ghazavi, Farzaneh" sort="Ghazavi, Farzaneh" uniqKey="Ghazavi F" first="Farzaneh" last="Ghazavi">Farzaneh Ghazavi</name><name sortKey="Goossens, Steven" sort="Goossens, Steven" uniqKey="Goossens S" first="Steven" last="Goossens">Steven Goossens</name><name sortKey="Goossens, Steven" sort="Goossens, Steven" uniqKey="Goossens S" first="Steven" last="Goossens">Steven Goossens</name><name sortKey="Helsmoortel, Hetty H" sort="Helsmoortel, Hetty H" uniqKey="Helsmoortel H" first="Hetty H." last="Helsmoortel">Hetty H. Helsmoortel</name><name sortKey="Labarque, Veerle" sort="Labarque, Veerle" uniqKey="Labarque V" first="Veerle" last="Labarque">Veerle Labarque</name><name sortKey="Lammens, Tim" sort="Lammens, Tim" uniqKey="Lammens T" first="Tim" last="Lammens">Tim Lammens</name><name sortKey="Pieters, Tim" sort="Pieters, Tim" uniqKey="Pieters T" first="Tim" last="Pieters">Tim Pieters</name><name sortKey="Pieters, Tim" sort="Pieters, Tim" uniqKey="Pieters T" first="Tim" last="Pieters">Tim Pieters</name><name sortKey="Pieters, Tim" sort="Pieters, Tim" uniqKey="Pieters T" first="Tim" last="Pieters">Tim Pieters</name><name sortKey="Speleman, Frank" sort="Speleman, Frank" uniqKey="Speleman F" first="Frank" last="Speleman">Frank Speleman</name><name sortKey="Van Roy, Nadine" sort="Van Roy, Nadine" uniqKey="Van Roy N" first="Nadine" last="Van Roy">Nadine Van Roy</name><name sortKey="Van Vlierberghe, Pieter" sort="Van Vlierberghe, Pieter" uniqKey="Van Vlierberghe P" first="Pieter" last="Van Vlierberghe">Pieter Van Vlierberghe</name></country><country name="Italie"><noRegion><name sortKey="Bresolin, Silvia" sort="Bresolin, Silvia" uniqKey="Bresolin S" first="Silvia" last="Bresolin">Silvia Bresolin</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Cave, Helene" sort="Cave, Helene" uniqKey="Cave H" first="Hélène" last="Cavé">Hélène Cavé</name></region></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="De Vries, Andrica" sort="De Vries, Andrica" uniqKey="De Vries A" first="Andrica" last="De Vries">Andrica De Vries</name></region><name sortKey="De Haas, Valerie" sort="De Haas, Valerie" uniqKey="De Haas V" first="Valerie" last="De Haas">Valerie De Haas</name><name sortKey="Van Den Heuvel Eibrink, Marry M" sort="Van Den Heuvel Eibrink, Marry M" uniqKey="Van Den Heuvel Eibrink M" first="Marry M." last="Van Den Heuvel-Eibrink">Marry M. Van Den Heuvel-Eibrink</name><name sortKey="Van Den Heuvel Eibrink, Marry M" sort="Van Den Heuvel Eibrink, Marry M" uniqKey="Van Den Heuvel Eibrink M" first="Marry M." last="Van Den Heuvel-Eibrink">Marry M. Van Den Heuvel-Eibrink</name></country><country name="Allemagne"><noRegion><name sortKey="Flotho, Christian" sort="Flotho, Christian" uniqKey="Flotho C" first="Christian" last="Flotho">Christian Flotho</name></noRegion><name sortKey="Niemeyer, Charlotte" sort="Niemeyer, Charlotte" uniqKey="Niemeyer C" first="Charlotte" last="Niemeyer">Charlotte Niemeyer</name><name sortKey="Schulte, Johannes" sort="Schulte, Johannes" uniqKey="Schulte J" first="Johannes" last="Schulte">Johannes Schulte</name><name sortKey="Schulte, Johannes" sort="Schulte, Johannes" uniqKey="Schulte J" first="Johannes" last="Schulte">Johannes Schulte</name><name sortKey="Schulte, Johannes" sort="Schulte, Johannes" uniqKey="Schulte J" first="Johannes" last="Schulte">Johannes Schulte</name><name sortKey="Schulte, Johannes" sort="Schulte, Johannes" uniqKey="Schulte J" first="Johannes" last="Schulte">Johannes Schulte</name><name sortKey="Schulte, Johannes" sort="Schulte, Johannes" uniqKey="Schulte J" first="Johannes" last="Schulte">Johannes Schulte</name></country><country name="République tchèque"><region name="Bohême centrale"><name sortKey="Stary, Jan" sort="Stary, Jan" uniqKey="Stary J" first="Jan" last="Stary">Jan Stary</name></region></country><country name="Australie"><noRegion><name sortKey="Haigh, Jody J" sort="Haigh, Jody J" uniqKey="Haigh J" first="Jody J." last="Haigh">Jody J. 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