Associations Between Retinal Pigment Epithelium and Drusen Volume Changes During the Lifecycle of Large Drusenoid Pigment Epithelial Detachments
Identifieur interne : 000B09 ( Pmc/Checkpoint ); précédent : 000B08; suivant : 000B10Associations Between Retinal Pigment Epithelium and Drusen Volume Changes During the Lifecycle of Large Drusenoid Pigment Epithelial Detachments
Auteurs : Chandrakumar Balaratnasingam [États-Unis, Australie] ; Lawrence A. Yannuzzi [États-Unis] ; Christine A. Curcio [États-Unis] ; William H. Morgan [États-Unis] ; Giuseppe Querques [France, Italie] ; Vittorio Capuano [France] ; Eric Souied [France, Italie] ; Jesse Jung [États-Unis] ; K. Bailey Freund [États-Unis]Source :
- Investigative Ophthalmology & Visual Science [ 0146-0404 ] ; 2016.
Abstract
Drusenoid pigment epithelial detachments (PEDs) are a defined path to atrophy in age-related macular degeneration (AMD). We analyzed the relationships between retinal pigment epithelium (RPE) and drusen volume changes during the PED lifecycle, using spectral-domain optical coherence tomography (SD-OCT).
Twenty-one cases of drusenoid PED tracked using SD-OCT through periods of growth and collapse were evaluated. Volumetric calculations and piece-wise linear regression analysis were used to determine the breakpoint between growth and collapse. Spectral-domain OCT scans were independently evaluated for the appearance of intraretinal hyperreflective foci, acquired vitelliform lesions (AVLs), and disruptions to the RPE+basal lamina band. Timing of these events with respect to the breakpoint was statistically evaluated. Morphometric characteristics of drusenoid PEDs were correlated with rate of PED collapse and final visual acuity.
Mean age of subjects was 75.3 years and mean period of follow up was 4.1 years (median 4.5 years; range, 0.6–6.6 years). The lifecycle of drusenoid PEDs was asymmetric, in that the rate of collapse (0.199 mm3/month) is significantly faster (
Spectral-domain OCT signatures, plausibly attributable to anteriorly migrated RPE and disintegration of the RPE layer, precede or occur simultaneously with changes in volume of drusenoid PED during the lifecycle of this lesion.
Url:
DOI: 10.1167/iovs.16-19816
PubMed: 27760262
PubMed Central: 5072538
Affiliations:
- Australie, France, Italie, États-Unis
- Alabama, Californie, Lombardie, État de New York, Île-de-France
- Créteil, Milan
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Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2">Vitreous-Retina-Macula Consultants of New York, New York, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vitreous-Retina-Macula Consultants of New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff8">East Bay Retina Consultants, Inc., Oakland, California, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>East Bay Retina Consultants, Inc., Oakland, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Freund, K Bailey" sort="Freund, K Bailey" uniqKey="Freund K" first="K. Bailey" last="Freund">K. Bailey Freund</name><affiliation wicri:level="2"><nlm:aff id="aff1">LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="aff3">Department of Ophthalmology, New York University School of Medicine, New York, New York, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, New York University School of Medicine, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27760262</idno><idno type="pmc">5072538</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072538</idno><idno type="RBID">PMC:5072538</idno><idno type="doi">10.1167/iovs.16-19816</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">002616</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002616</idno><idno type="wicri:Area/Pmc/Curation">002466</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002466</idno><idno type="wicri:Area/Pmc/Checkpoint">000B09</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000B09</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Associations Between Retinal Pigment Epithelium and Drusen Volume Changes During the Lifecycle of Large Drusenoid Pigment Epithelial Detachments</title><author><name sortKey="Balaratnasingam, Chandrakumar" sort="Balaratnasingam, Chandrakumar" uniqKey="Balaratnasingam C" first="Chandrakumar" last="Balaratnasingam">Chandrakumar Balaratnasingam</name><affiliation wicri:level="2"><nlm:aff id="aff1">LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Physiology and Pharmacology, Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Physiology and Pharmacology, Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth</wicri:regionArea><wicri:noRegion>Perth</wicri:noRegion></affiliation></author><author><name sortKey="Yannuzzi, Lawrence A" sort="Yannuzzi, Lawrence A" uniqKey="Yannuzzi L" first="Lawrence A." last="Yannuzzi">Lawrence A. Yannuzzi</name><affiliation wicri:level="2"><nlm:aff id="aff1">LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2">Vitreous-Retina-Macula Consultants of New York, New York, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vitreous-Retina-Macula Consultants of New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Curcio, Christine A" sort="Curcio, Christine A" uniqKey="Curcio C" first="Christine A." last="Curcio">Christine A. Curcio</name><affiliation wicri:level="2"><nlm:aff id="aff5">Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, Alabama, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, Alabama</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Morgan, William H" sort="Morgan, William H" uniqKey="Morgan W" first="William H." last="Morgan">William H. Morgan</name><affiliation wicri:level="2"><nlm:aff id="aff3">Department of Ophthalmology, New York University School of Medicine, New York, New York, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, New York University School of Medicine, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Querques, Giuseppe" sort="Querques, Giuseppe" uniqKey="Querques G" first="Giuseppe" last="Querques">Giuseppe Querques</name><affiliation wicri:level="3"><nlm:aff id="aff6">Department of Ophthalmology, Hospital Intercommunal de Creteil, University Paris Est Creteil, Creteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Ophthalmology, Hospital Intercommunal de Creteil, University Paris Est Creteil, Creteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff7">Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Capuano, Vittorio" sort="Capuano, Vittorio" uniqKey="Capuano V" first="Vittorio" last="Capuano">Vittorio Capuano</name><affiliation wicri:level="3"><nlm:aff id="aff6">Department of Ophthalmology, Hospital Intercommunal de Creteil, University Paris Est Creteil, Creteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Ophthalmology, Hospital Intercommunal de Creteil, University Paris Est Creteil, Creteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Souied, Eric" sort="Souied, Eric" uniqKey="Souied E" first="Eric" last="Souied">Eric Souied</name><affiliation wicri:level="3"><nlm:aff id="aff6">Department of Ophthalmology, Hospital Intercommunal de Creteil, University Paris Est Creteil, Creteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Ophthalmology, Hospital Intercommunal de Creteil, University Paris Est Creteil, Creteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff7">Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Jung, Jesse" sort="Jung, Jesse" uniqKey="Jung J" first="Jesse" last="Jung">Jesse Jung</name><affiliation wicri:level="2"><nlm:aff id="aff1">LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2">Vitreous-Retina-Macula Consultants of New York, New York, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vitreous-Retina-Macula Consultants of New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff8">East Bay Retina Consultants, Inc., Oakland, California, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>East Bay Retina Consultants, Inc., Oakland, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Freund, K Bailey" sort="Freund, K Bailey" uniqKey="Freund K" first="K. Bailey" last="Freund">K. Bailey Freund</name><affiliation wicri:level="2"><nlm:aff id="aff1">LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="aff3">Department of Ophthalmology, New York University School of Medicine, New York, New York, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, New York University School of Medicine, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j">Investigative Ophthalmology & Visual Science</title><idno type="ISSN">0146-0404</idno><idno type="eISSN">1552-5783</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Purpose</title><p>Drusenoid pigment epithelial detachments (PEDs) are a defined path to atrophy in age-related macular degeneration (AMD). We analyzed the relationships between retinal pigment epithelium (RPE) and drusen volume changes during the PED lifecycle, using spectral-domain optical coherence tomography (SD-OCT).</p></sec><sec id="st2"><title>Methods</title><p>Twenty-one cases of drusenoid PED tracked using SD-OCT through periods of growth and collapse were evaluated. Volumetric calculations and piece-wise linear regression analysis were used to determine the breakpoint between growth and collapse. Spectral-domain OCT scans were independently evaluated for the appearance of intraretinal hyperreflective foci, acquired vitelliform lesions (AVLs), and disruptions to the RPE+basal lamina band. Timing of these events with respect to the breakpoint was statistically evaluated. Morphometric characteristics of drusenoid PEDs were correlated with rate of PED collapse and final visual acuity.</p></sec><sec id="st3"><title>Results</title><p>Mean age of subjects was 75.3 years and mean period of follow up was 4.1 years (median 4.5 years; range, 0.6–6.6 years). The lifecycle of drusenoid PEDs was asymmetric, in that the rate of collapse (0.199 mm<sup>3</sup>/month) is significantly faster (<italic>P</italic> < 0.001) than the rate of growth (0.022 mm<sup>3</sup>/month). Appearance of intraretinal hyperreflective foci and AVLs preceded the breakpoint (both <italic>P</italic> < 0.001). The timing of disruptions to the RPE+basal lamina band did not differ from the breakpoint (<italic>P</italic> = 0.510). Maximal height, volume, and diameter of drusenoid PEDs were inversely correlated with final visual acuity (all <italic>P</italic> < 0.001) and positively correlated with the rate of PED collapse (all <italic>P</italic> < 0.001).</p></sec><sec id="st4"><title>Conclusions</title><p>Spectral-domain OCT signatures, plausibly attributable to anteriorly migrated RPE and disintegration of the RPE layer, precede or occur simultaneously with changes in volume of drusenoid PED during the lifecycle of this lesion.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Klein, R" uniqKey="Klein R">R, Klein</name></author><author><name sortKey="Klein, Be" uniqKey="Klein B">BE, Klein</name></author><author><name sortKey="Tomany, Sc" uniqKey="Tomany S">SC, Tomany</name></author><author><name sortKey="Meuer, Sm" uniqKey="Meuer S">SM, Meuer</name></author><author><name sortKey="Huang, Gh" uniqKey="Huang G">GH. Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cukras, C" uniqKey="Cukras C">C, Cukras</name></author><author><name sortKey="Agron, E" uniqKey="Agron E">E, Agron</name></author><author><name sortKey="Klein, Ml" uniqKey="Klein M">ML, Klein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mrejen, S" uniqKey="Mrejen S">S, Mrejen</name></author><author><name sortKey="Sarraf, D" uniqKey="Sarraf D">D, Sarraf</name></author><author><name sortKey="Mukkamala, Sk" uniqKey="Mukkamala S">SK, Mukkamala</name></author><author><name sortKey="Freund, Kb" uniqKey="Freund K">KB. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Invest Ophthalmol Vis Sci</journal-id><journal-id journal-id-type="iso-abbrev">Invest. Ophthalmol. Vis. Sci</journal-id><journal-id journal-id-type="hwp">iovs</journal-id><journal-id journal-id-type="pmc">iovs</journal-id><journal-id journal-id-type="publisher-id">iovs</journal-id><journal-title-group><journal-title>Investigative Ophthalmology & Visual Science</journal-title></journal-title-group><issn pub-type="ppub">0146-0404</issn><issn pub-type="epub">1552-5783</issn><publisher><publisher-name>The Association for Research in Vision and Ophthalmology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27760262</article-id><article-id pub-id-type="pmc">5072538</article-id><article-id pub-id-type="doi">10.1167/iovs.16-19816</article-id><article-id pub-id-type="sici">iovs-57-11-41</article-id><article-id pub-id-type="publisher-id">IOVS-16-19816</article-id><article-categories><subj-group subj-group-type="heading"><subject>Retina</subject></subj-group></article-categories><title-group><article-title>Associations Between Retinal Pigment Epithelium and Drusen Volume Changes During the Lifecycle of Large Drusenoid Pigment Epithelial Detachments</article-title><alt-title alt-title-type="runhead">RPE and Lifecycle of Drusenoid PEDs</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Balaratnasingam</surname><given-names>Chandrakumar</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2"></xref><xref ref-type="aff" rid="aff3"></xref><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Yannuzzi</surname><given-names>Lawrence A.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Curcio</surname><given-names>Christine A.</given-names></name><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Morgan</surname><given-names>William H.</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Querques</surname><given-names>Giuseppe</given-names></name><xref ref-type="aff" rid="aff6">6</xref><xref ref-type="aff" rid="aff7">7</xref></contrib><contrib contrib-type="author"><name><surname>Capuano</surname><given-names>Vittorio</given-names></name><xref ref-type="aff" rid="aff6">6</xref></contrib><contrib contrib-type="author"><name><surname>Souied</surname><given-names>Eric</given-names></name><xref ref-type="aff" rid="aff6">6</xref><xref ref-type="aff" rid="aff7">7</xref></contrib><contrib contrib-type="author"><name><surname>Jung</surname><given-names>Jesse</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff8">8</xref></contrib><contrib contrib-type="author"><name><surname>Freund</surname><given-names>K. Bailey</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2"></xref><xref ref-type="aff" rid="aff3">3</xref></contrib><aff id="aff1"><label>1</label>LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, United States</aff><aff id="aff2"><label>2</label>Vitreous-Retina-Macula Consultants of New York, New York, United States</aff><aff id="aff3"><label>3</label>Department of Ophthalmology, New York University School of Medicine, New York, New York, United States</aff><aff id="aff4"><label>4</label>Department of Physiology and Pharmacology, Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Australia</aff><aff id="aff5"><label>5</label>Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, Alabama, United States</aff><aff id="aff6"><label>6</label>Department of Ophthalmology, Hospital Intercommunal de Creteil, University Paris Est Creteil, Creteil, France</aff><aff id="aff7"><label>7</label>Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy</aff><aff id="aff8"><label>8</label>East Bay Retina Consultants, Inc., Oakland, California, United States</aff></contrib-group><author-notes><corresp id="cor1">Correspondence: K. Bailey Freund, Vitreous Retina Macula Consultants of New York, 460 Park Avenue, 5th Floor, New York, NY 10022, USA; <email>kbfnyf@aol.com</email>.</corresp></author-notes><pub-date pub-type="ppub"><month>10</month><year>2016</year></pub-date><volume>57</volume><issue>13</issue><fpage>5479</fpage><lpage>5489</lpage><history><date date-type="received"><day>25</day><month>4</month><year>2016</year></date><date date-type="accepted"><day>4</day><month>9</month><year>2016</year></date></history><permissions><license license-type="cc-by-nc-nd" xlink:href="http://creativecommons.org/licenses/by-nc-nd/4.0/"><license-p>This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.</license-p></license></permissions><self-uri xlink:title="pdf" xlink:href="i1552-5783-57-13-5479.pdf"></self-uri><abstract><sec id="st1"><title>Purpose</title><p>Drusenoid pigment epithelial detachments (PEDs) are a defined path to atrophy in age-related macular degeneration (AMD). We analyzed the relationships between retinal pigment epithelium (RPE) and drusen volume changes during the PED lifecycle, using spectral-domain optical coherence tomography (SD-OCT).</p></sec><sec id="st2"><title>Methods</title><p>Twenty-one cases of drusenoid PED tracked using SD-OCT through periods of growth and collapse were evaluated. Volumetric calculations and piece-wise linear regression analysis were used to determine the breakpoint between growth and collapse. Spectral-domain OCT scans were independently evaluated for the appearance of intraretinal hyperreflective foci, acquired vitelliform lesions (AVLs), and disruptions to the RPE+basal lamina band. Timing of these events with respect to the breakpoint was statistically evaluated. Morphometric characteristics of drusenoid PEDs were correlated with rate of PED collapse and final visual acuity.</p></sec><sec id="st3"><title>Results</title><p>Mean age of subjects was 75.3 years and mean period of follow up was 4.1 years (median 4.5 years; range, 0.6–6.6 years). The lifecycle of drusenoid PEDs was asymmetric, in that the rate of collapse (0.199 mm<sup>3</sup>/month) is significantly faster (<italic>P</italic> < 0.001) than the rate of growth (0.022 mm<sup>3</sup>/month). Appearance of intraretinal hyperreflective foci and AVLs preceded the breakpoint (both <italic>P</italic> < 0.001). The timing of disruptions to the RPE+basal lamina band did not differ from the breakpoint (<italic>P</italic> = 0.510). Maximal height, volume, and diameter of drusenoid PEDs were inversely correlated with final visual acuity (all <italic>P</italic> < 0.001) and positively correlated with the rate of PED collapse (all <italic>P</italic> < 0.001).</p></sec><sec id="st4"><title>Conclusions</title><p>Spectral-domain OCT signatures, plausibly attributable to anteriorly migrated RPE and disintegration of the RPE layer, precede or occur simultaneously with changes in volume of drusenoid PED during the lifecycle of this lesion.</p></sec></abstract><kwd-group><title>Keywords</title><kwd>AMD</kwd><kwd>drusen</kwd><kwd>geographic atrophy</kwd><kwd>pigment epithelial detachment</kwd><kwd>retinal pigment epithelium</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Australie</li><li>France</li><li>Italie</li><li>États-Unis</li></country><region><li>Alabama</li><li>Californie</li><li>Lombardie</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Créteil</li><li>Milan</li></settlement></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Balaratnasingam, Chandrakumar" sort="Balaratnasingam, Chandrakumar" uniqKey="Balaratnasingam C" first="Chandrakumar" last="Balaratnasingam">Chandrakumar Balaratnasingam</name></region><name sortKey="Curcio, Christine A" sort="Curcio, Christine A" uniqKey="Curcio C" first="Christine A." last="Curcio">Christine A. Curcio</name><name sortKey="Freund, K Bailey" sort="Freund, K Bailey" uniqKey="Freund K" first="K. Bailey" last="Freund">K. Bailey Freund</name><name sortKey="Freund, K Bailey" sort="Freund, K Bailey" uniqKey="Freund K" first="K. Bailey" last="Freund">K. Bailey Freund</name><name sortKey="Jung, Jesse" sort="Jung, Jesse" uniqKey="Jung J" first="Jesse" last="Jung">Jesse Jung</name><name sortKey="Jung, Jesse" sort="Jung, Jesse" uniqKey="Jung J" first="Jesse" last="Jung">Jesse Jung</name><name sortKey="Jung, Jesse" sort="Jung, Jesse" uniqKey="Jung J" first="Jesse" last="Jung">Jesse Jung</name><name sortKey="Morgan, William H" sort="Morgan, William H" uniqKey="Morgan W" first="William H." last="Morgan">William H. Morgan</name><name sortKey="Yannuzzi, Lawrence A" sort="Yannuzzi, Lawrence A" uniqKey="Yannuzzi L" first="Lawrence A." last="Yannuzzi">Lawrence A. Yannuzzi</name><name sortKey="Yannuzzi, Lawrence A" sort="Yannuzzi, Lawrence A" uniqKey="Yannuzzi L" first="Lawrence A." last="Yannuzzi">Lawrence A. Yannuzzi</name></country><country name="Australie"><noRegion><name sortKey="Balaratnasingam, Chandrakumar" sort="Balaratnasingam, Chandrakumar" uniqKey="Balaratnasingam C" first="Chandrakumar" last="Balaratnasingam">Chandrakumar Balaratnasingam</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Querques, Giuseppe" sort="Querques, Giuseppe" uniqKey="Querques G" first="Giuseppe" last="Querques">Giuseppe Querques</name></region><name sortKey="Capuano, Vittorio" sort="Capuano, Vittorio" uniqKey="Capuano V" first="Vittorio" last="Capuano">Vittorio Capuano</name><name sortKey="Souied, Eric" sort="Souied, Eric" uniqKey="Souied E" first="Eric" last="Souied">Eric Souied</name></country><country name="Italie"><region name="Lombardie"><name sortKey="Querques, Giuseppe" sort="Querques, Giuseppe" uniqKey="Querques G" first="Giuseppe" last="Querques">Giuseppe Querques</name></region><name sortKey="Souied, Eric" sort="Souied, Eric" uniqKey="Souied E" first="Eric" last="Souied">Eric Souied</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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