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Characterization of leukemias with ETV6-ABL1 fusion

Identifieur interne : 000A78 ( Pmc/Checkpoint ); précédent : 000A77; suivant : 000A79

Characterization of leukemias with ETV6-ABL1 fusion

Auteurs : Marketa Zaliova [République tchèque] ; Anthony V. Moorman [Royaume-Uni] ; Giovanni Cazzaniga [Italie] ; Martin Stanulla [Allemagne] ; Richard C. Harvey [États-Unis] ; Kathryn G. Roberts [États-Unis] ; Sue L. Heatley [Australie] ; Mignon L. Loh [États-Unis] ; Marina Konopleva [États-Unis] ; I-Ming Chen [États-Unis] ; Olga Zimmermannova [République tchèque] ; Claire Schwab [Royaume-Uni] ; Owen Smith [Irlande (pays)] ; Marie-Joelle Mozziconacci [France] ; Christian Chabannon [France] ; Myungshin Kim [Corée du Sud] ; J. H. Frederik Falkenburg [Pays-Bas] ; Alice Norton [Royaume-Uni] ; Karen Marshall [Royaume-Uni] ; Oskar A. Haas [Autriche] ; Julia Starkova [République tchèque] ; Jan Stuchly [République tchèque] ; Stephen P. Hunger [États-Unis] ; Deborah White [Australie] ; Charles G. Mullighan [États-Unis] ; Cheryl L. Willman [États-Unis] ; Jan Stary [République tchèque] ; Jan Trka [République tchèque] ; Jan Zuna [République tchèque]

Source :

RBID : PMC:5060025

Abstract

To characterize the incidence, clinical features and genetics of ETV6-ABL1 leukemias, representing targetable kinase-activating lesions, we analyzed 44 new and published cases of ETV6-ABL1-positive hematologic malignancies [22 cases of acute lymphoblastic leukemia (13 children, 9 adults) and 22 myeloid malignancies (18 myeloproliferative neoplasms, 4 acute myeloid leukemias)]. The presence of the ETV6-ABL1 fusion was ascertained by cytogenetics, fluorescence in-situ hybridization, reverse transcriptase-polymerase chain reaction and RNA sequencing. Genomic and gene expression profiling was performed by single nucleotide polymorphism and expression arrays. Systematic screening of more than 4,500 cases revealed that in acute lymphoblastic leukemia ETV6-ABL1 is rare in childhood (0.17% cases) and slightly more common in adults (0.38%). There is no systematic screening of myeloproliferative neoplasms; however, the number of ETV6-ABL1-positive cases and the relative incidence of acute lymphoblastic leukemia and myeloproliferative neoplasms suggest that in adulthood ETV6-ABL1 is more common in BCR-ABL1-negative chronic myeloid leukemia-like myeloproliferations than in acute lymphoblastic leukemia. The genomic profile of ETV6-ABL1 acute lymphoblastic leukemia resembled that of BCR-ABL1 and BCR-ABL1-like cases with 80% of patients having concurrent CDKN2A/B and IKZF1 deletions. In the gene expression profiling all the ETV6-ABL1-positive samples clustered in close vicinity to BCR-ABL1 cases. All but one of the cases of ETV6-ABL1 acute lymphoblastic leukemia were classified as BCR-ABL1-like by a standardized assay. Over 60% of patients died, irrespectively of the disease or age subgroup examined. In conclusion, ETV6-ABL1 fusion occurs in both lymphoid and myeloid leukemias; the genomic profile and clinical behavior resemble BCR-ABL1-positive malignancies, including the unfavorable prognosis, particularly of acute leukemias. The poor outcome suggests that treatment with tyrosine kinase inhibitors should be considered for patients with this fusion.


Url:
DOI: 10.3324/haematol.2016.144345
PubMed: 27229714
PubMed Central: 5060025


Affiliations:


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PMC:5060025

Le document en format XML

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<name sortKey="Cazzaniga, Giovanni" sort="Cazzaniga, Giovanni" uniqKey="Cazzaniga G" first="Giovanni" last="Cazzaniga">Giovanni Cazzaniga</name>
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<name sortKey="Roberts, Kathryn G" sort="Roberts, Kathryn G" uniqKey="Roberts K" first="Kathryn G." last="Roberts">Kathryn G. Roberts</name>
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<name sortKey="Heatley, Sue L" sort="Heatley, Sue L" uniqKey="Heatley S" first="Sue L." last="Heatley">Sue L. Heatley</name>
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<name sortKey="Loh, Mignon L" sort="Loh, Mignon L" uniqKey="Loh M" first="Mignon L." last="Loh">Mignon L. Loh</name>
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<name sortKey="Konopleva, Marina" sort="Konopleva, Marina" uniqKey="Konopleva M" first="Marina" last="Konopleva">Marina Konopleva</name>
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<name sortKey="Chen, I Ming" sort="Chen, I Ming" uniqKey="Chen I" first="I-Ming" last="Chen">I-Ming Chen</name>
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<name sortKey="Zimmermannova, Olga" sort="Zimmermannova, Olga" uniqKey="Zimmermannova O" first="Olga" last="Zimmermannova">Olga Zimmermannova</name>
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Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic</nlm:aff>
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<name sortKey="Schwab, Claire" sort="Schwab, Claire" uniqKey="Schwab C" first="Claire" last="Schwab">Claire Schwab</name>
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<name sortKey="Smith, Owen" sort="Smith, Owen" uniqKey="Smith O" first="Owen" last="Smith">Owen Smith</name>
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<wicri:regionArea>Department of Haematology, Our Lady’s Children’s Hospital, Dublin</wicri:regionArea>
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<name sortKey="Mozziconacci, Marie Joelle" sort="Mozziconacci, Marie Joelle" uniqKey="Mozziconacci M" first="Marie-Joelle" last="Mozziconacci">Marie-Joelle Mozziconacci</name>
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<name sortKey="Chabannon, Christian" sort="Chabannon, Christian" uniqKey="Chabannon C" first="Christian" last="Chabannon">Christian Chabannon</name>
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<nlm:aff id="af12-1011082">Department of Hematology, Institut Paoli Calmettes, Marseille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Hematology, Institut Paoli Calmettes, Marseille</wicri:regionArea>
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<name sortKey="Kim, Myungshin" sort="Kim, Myungshin" uniqKey="Kim M" first="Myungshin" last="Kim">Myungshin Kim</name>
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<nlm:aff id="af13-1011082">Department of Laboratory Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Laboratory Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul</wicri:regionArea>
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<settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
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<name sortKey="Frederik Falkenburg, J H" sort="Frederik Falkenburg, J H" uniqKey="Frederik Falkenburg J" first="J. H." last="Frederik Falkenburg">J. H. Frederik Falkenburg</name>
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<nlm:aff id="af14-1011082">Department of Hematology, Leiden University Medical Center, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
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<wicri:noRegion>Leiden University Medical Center</wicri:noRegion>
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<name sortKey="Norton, Alice" sort="Norton, Alice" uniqKey="Norton A" first="Alice" last="Norton">Alice Norton</name>
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<nlm:aff id="af15-1011082">Birmingham Children’s Hospital, NHS Foundation Trust, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Birmingham Children’s Hospital, NHS Foundation Trust</wicri:regionArea>
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<name sortKey="Marshall, Karen" sort="Marshall, Karen" uniqKey="Marshall K" first="Karen" last="Marshall">Karen Marshall</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cytogenetics, Leicester Royal Infirmary NHS Trust</wicri:regionArea>
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<name sortKey="Haas, Oskar A" sort="Haas, Oskar A" uniqKey="Haas O" first="Oskar A." last="Haas">Oskar A. Haas</name>
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<name sortKey="Starkova, Julia" sort="Starkova, Julia" uniqKey="Starkova J" first="Julia" last="Starkova">Julia Starkova</name>
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<nlm:aff id="af1-1011082">CLIP, Department of Pediatric Hematology and Oncology, 2
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Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic</nlm:aff>
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<name sortKey="Stuchly, Jan" sort="Stuchly, Jan" uniqKey="Stuchly J" first="Jan" last="Stuchly">Jan Stuchly</name>
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<nlm:aff id="af1-1011082">CLIP, Department of Pediatric Hematology and Oncology, 2
<sup>nd</sup>
Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea> Faculty of Medicine, Charles University and University Hospital Motol, Prague</wicri:regionArea>
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<name sortKey="Hunger, Stephen P" sort="Hunger, Stephen P" uniqKey="Hunger S" first="Stephen P." last="Hunger">Stephen P. Hunger</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics and the Center for Childhood Cancer Research, Children’s Hospital of Philadelphia and the University of Pennsylvania Perelman School of Medicine, PA</wicri:regionArea>
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<region type="state">Pennsylvanie</region>
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<author>
<name sortKey="White, Deborah" sort="White, Deborah" uniqKey="White D" first="Deborah" last="White">Deborah White</name>
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<country xml:lang="fr">Australie</country>
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<wicri:noRegion>Adelaide</wicri:noRegion>
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<author>
<name sortKey="Mullighan, Charles G" sort="Mullighan, Charles G" uniqKey="Mullighan C" first="Charles G." last="Mullighan">Charles G. Mullighan</name>
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<nlm:aff id="af6-1011082">Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN, USA</nlm:aff>
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<wicri:regionArea>Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN</wicri:regionArea>
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<region type="state">Tennessee</region>
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<name sortKey="Willman, Cheryl L" sort="Willman, Cheryl L" uniqKey="Willman C" first="Cheryl L." last="Willman">Cheryl L. Willman</name>
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<nlm:aff id="af5-1011082">University of New Mexico Cancer Center, Albuquerque, NM, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of New Mexico Cancer Center, Albuquerque, NM</wicri:regionArea>
<placeName>
<region type="state">Nouveau-Mexique</region>
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<name sortKey="Stary, Jan" sort="Stary, Jan" uniqKey="Stary J" first="Jan" last="Stary">Jan Stary</name>
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<nlm:aff id="af1-1011082">CLIP, Department of Pediatric Hematology and Oncology, 2
<sup>nd</sup>
Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic</nlm:aff>
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<wicri:regionArea> Faculty of Medicine, Charles University and University Hospital Motol, Prague</wicri:regionArea>
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<name sortKey="Trka, Jan" sort="Trka, Jan" uniqKey="Trka J" first="Jan" last="Trka">Jan Trka</name>
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<sup>nd</sup>
Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic</nlm:aff>
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<name sortKey="Zuna, Jan" sort="Zuna, Jan" uniqKey="Zuna J" first="Jan" last="Zuna">Jan Zuna</name>
<affiliation wicri:level="3">
<nlm:aff id="af1-1011082">CLIP, Department of Pediatric Hematology and Oncology, 2
<sup>nd</sup>
Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea> Faculty of Medicine, Charles University and University Hospital Motol, Prague</wicri:regionArea>
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<settlement type="city">Prague</settlement>
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<title xml:lang="en" level="a" type="main">Characterization of leukemias with
<italic>ETV6-ABL1</italic>
fusion</title>
<author>
<name sortKey="Zaliova, Marketa" sort="Zaliova, Marketa" uniqKey="Zaliova M" first="Marketa" last="Zaliova">Marketa Zaliova</name>
<affiliation wicri:level="3">
<nlm:aff id="af1-1011082">CLIP, Department of Pediatric Hematology and Oncology, 2
<sup>nd</sup>
Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea> Faculty of Medicine, Charles University and University Hospital Motol, Prague</wicri:regionArea>
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<settlement type="city">Prague</settlement>
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</placeName>
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<name sortKey="Moorman, Anthony V" sort="Moorman, Anthony V" uniqKey="Moorman A" first="Anthony V." last="Moorman">Anthony V. Moorman</name>
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<nlm:aff id="af2-1011082">Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne</wicri:regionArea>
<wicri:noRegion>Newcastle upon Tyne</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Cazzaniga, Giovanni" sort="Cazzaniga, Giovanni" uniqKey="Cazzaniga G" first="Giovanni" last="Cazzaniga">Giovanni Cazzaniga</name>
<affiliation wicri:level="1">
<nlm:aff id="af3-1011082">Centro Ricerca Tettamanti, Clinica Pediatrica, Università di Milano-Bicocca, Fondazione MBBM/Ospedale San Gerardo, Monza, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Centro Ricerca Tettamanti, Clinica Pediatrica, Università di Milano-Bicocca, Fondazione MBBM/Ospedale San Gerardo, Monza</wicri:regionArea>
<wicri:noRegion>Monza</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Stanulla, Martin" sort="Stanulla, Martin" uniqKey="Stanulla M" first="Martin" last="Stanulla">Martin Stanulla</name>
<affiliation wicri:level="1">
<nlm:aff id="af4-1011082">Pediatric Hematology and Oncology, Hannover Medical School, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Pediatric Hematology and Oncology, Hannover Medical School</wicri:regionArea>
<wicri:noRegion>Hannover Medical School</wicri:noRegion>
<wicri:noRegion>Hannover Medical School</wicri:noRegion>
<wicri:noRegion>Hannover Medical School</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Harvey, Richard C" sort="Harvey, Richard C" uniqKey="Harvey R" first="Richard C." last="Harvey">Richard C. Harvey</name>
<affiliation wicri:level="2">
<nlm:aff id="af5-1011082">University of New Mexico Cancer Center, Albuquerque, NM, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of New Mexico Cancer Center, Albuquerque, NM</wicri:regionArea>
<placeName>
<region type="state">Nouveau-Mexique</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Roberts, Kathryn G" sort="Roberts, Kathryn G" uniqKey="Roberts K" first="Kathryn G." last="Roberts">Kathryn G. Roberts</name>
<affiliation wicri:level="2">
<nlm:aff id="af6-1011082">Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN</wicri:regionArea>
<placeName>
<region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Heatley, Sue L" sort="Heatley, Sue L" uniqKey="Heatley S" first="Sue L." last="Heatley">Sue L. Heatley</name>
<affiliation wicri:level="1">
<nlm:aff id="af7-1011082">South Australia Health and Medical Research Institute, Adelaide, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>South Australia Health and Medical Research Institute, Adelaide</wicri:regionArea>
<wicri:noRegion>Adelaide</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Loh, Mignon L" sort="Loh, Mignon L" uniqKey="Loh M" first="Mignon L." last="Loh">Mignon L. Loh</name>
<affiliation wicri:level="2">
<nlm:aff id="af8-1011082">Department of Pediatrics, Hematology-Oncology, Benioff Children’s Hospital, and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, Hematology-Oncology, Benioff Children’s Hospital, and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA</wicri:regionArea>
<placeName>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Konopleva, Marina" sort="Konopleva, Marina" uniqKey="Konopleva M" first="Marina" last="Konopleva">Marina Konopleva</name>
<affiliation wicri:level="2">
<nlm:aff id="af9-1011082">Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX</wicri:regionArea>
<placeName>
<region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Chen, I Ming" sort="Chen, I Ming" uniqKey="Chen I" first="I-Ming" last="Chen">I-Ming Chen</name>
<affiliation wicri:level="2">
<nlm:aff id="af5-1011082">University of New Mexico Cancer Center, Albuquerque, NM, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of New Mexico Cancer Center, Albuquerque, NM</wicri:regionArea>
<placeName>
<region type="state">Nouveau-Mexique</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Zimmermannova, Olga" sort="Zimmermannova, Olga" uniqKey="Zimmermannova O" first="Olga" last="Zimmermannova">Olga Zimmermannova</name>
<affiliation wicri:level="3">
<nlm:aff id="af1-1011082">CLIP, Department of Pediatric Hematology and Oncology, 2
<sup>nd</sup>
Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea> Faculty of Medicine, Charles University and University Hospital Motol, Prague</wicri:regionArea>
<placeName>
<settlement type="city">Prague</settlement>
<region type="région" nuts="2">Bohême centrale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Schwab, Claire" sort="Schwab, Claire" uniqKey="Schwab C" first="Claire" last="Schwab">Claire Schwab</name>
<affiliation wicri:level="1">
<nlm:aff id="af2-1011082">Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne</wicri:regionArea>
<wicri:noRegion>Newcastle upon Tyne</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Smith, Owen" sort="Smith, Owen" uniqKey="Smith O" first="Owen" last="Smith">Owen Smith</name>
<affiliation wicri:level="1">
<nlm:aff id="af10-1011082">Department of Haematology, Our Lady’s Children’s Hospital, Dublin, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Department of Haematology, Our Lady’s Children’s Hospital, Dublin</wicri:regionArea>
<wicri:noRegion>Dublin</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Mozziconacci, Marie Joelle" sort="Mozziconacci, Marie Joelle" uniqKey="Mozziconacci M" first="Marie-Joelle" last="Mozziconacci">Marie-Joelle Mozziconacci</name>
<affiliation wicri:level="3">
<nlm:aff id="af11-1011082">Department of Cancer Biology, Institut Paoli Calmettes, Marseille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Cancer Biology, Institut Paoli Calmettes, Marseille</wicri:regionArea>
<placeName>
<region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Chabannon, Christian" sort="Chabannon, Christian" uniqKey="Chabannon C" first="Christian" last="Chabannon">Christian Chabannon</name>
<affiliation wicri:level="3">
<nlm:aff id="af12-1011082">Department of Hematology, Institut Paoli Calmettes, Marseille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Hematology, Institut Paoli Calmettes, Marseille</wicri:regionArea>
<placeName>
<region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kim, Myungshin" sort="Kim, Myungshin" uniqKey="Kim M" first="Myungshin" last="Kim">Myungshin Kim</name>
<affiliation wicri:level="3">
<nlm:aff id="af13-1011082">Department of Laboratory Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Laboratory Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul</wicri:regionArea>
<placeName>
<settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Frederik Falkenburg, J H" sort="Frederik Falkenburg, J H" uniqKey="Frederik Falkenburg J" first="J. H." last="Frederik Falkenburg">J. H. Frederik Falkenburg</name>
<affiliation wicri:level="1">
<nlm:aff id="af14-1011082">Department of Hematology, Leiden University Medical Center, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Hematology, Leiden University Medical Center</wicri:regionArea>
<wicri:noRegion>Leiden University Medical Center</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Norton, Alice" sort="Norton, Alice" uniqKey="Norton A" first="Alice" last="Norton">Alice Norton</name>
<affiliation wicri:level="1">
<nlm:aff id="af15-1011082">Birmingham Children’s Hospital, NHS Foundation Trust, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Birmingham Children’s Hospital, NHS Foundation Trust</wicri:regionArea>
<wicri:noRegion>NHS Foundation Trust</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Marshall, Karen" sort="Marshall, Karen" uniqKey="Marshall K" first="Karen" last="Marshall">Karen Marshall</name>
<affiliation wicri:level="1">
<nlm:aff id="af16-1011082">Department of Cytogenetics, Leicester Royal Infirmary NHS Trust, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cytogenetics, Leicester Royal Infirmary NHS Trust</wicri:regionArea>
<wicri:noRegion>Leicester Royal Infirmary NHS Trust</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Haas, Oskar A" sort="Haas, Oskar A" uniqKey="Haas O" first="Oskar A." last="Haas">Oskar A. Haas</name>
<affiliation wicri:level="3">
<nlm:aff id="af17-1011082">St. Anna Children’s Hospital, Childrens Cancer Research Institute, Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>St. Anna Children’s Hospital, Childrens Cancer Research Institute, Vienna</wicri:regionArea>
<placeName>
<settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Starkova, Julia" sort="Starkova, Julia" uniqKey="Starkova J" first="Julia" last="Starkova">Julia Starkova</name>
<affiliation wicri:level="3">
<nlm:aff id="af1-1011082">CLIP, Department of Pediatric Hematology and Oncology, 2
<sup>nd</sup>
Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea> Faculty of Medicine, Charles University and University Hospital Motol, Prague</wicri:regionArea>
<placeName>
<settlement type="city">Prague</settlement>
<region type="région" nuts="2">Bohême centrale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Stuchly, Jan" sort="Stuchly, Jan" uniqKey="Stuchly J" first="Jan" last="Stuchly">Jan Stuchly</name>
<affiliation wicri:level="3">
<nlm:aff id="af1-1011082">CLIP, Department of Pediatric Hematology and Oncology, 2
<sup>nd</sup>
Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea> Faculty of Medicine, Charles University and University Hospital Motol, Prague</wicri:regionArea>
<placeName>
<settlement type="city">Prague</settlement>
<region type="région" nuts="2">Bohême centrale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hunger, Stephen P" sort="Hunger, Stephen P" uniqKey="Hunger S" first="Stephen P." last="Hunger">Stephen P. Hunger</name>
<affiliation wicri:level="2">
<nlm:aff id="af18-1011082">Department of Pediatrics and the Center for Childhood Cancer Research, Children’s Hospital of Philadelphia and the University of Pennsylvania Perelman School of Medicine, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics and the Center for Childhood Cancer Research, Children’s Hospital of Philadelphia and the University of Pennsylvania Perelman School of Medicine, PA</wicri:regionArea>
<placeName>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="White, Deborah" sort="White, Deborah" uniqKey="White D" first="Deborah" last="White">Deborah White</name>
<affiliation wicri:level="1">
<nlm:aff id="af7-1011082">South Australia Health and Medical Research Institute, Adelaide, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>South Australia Health and Medical Research Institute, Adelaide</wicri:regionArea>
<wicri:noRegion>Adelaide</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Mullighan, Charles G" sort="Mullighan, Charles G" uniqKey="Mullighan C" first="Charles G." last="Mullighan">Charles G. Mullighan</name>
<affiliation wicri:level="2">
<nlm:aff id="af6-1011082">Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN</wicri:regionArea>
<placeName>
<region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Willman, Cheryl L" sort="Willman, Cheryl L" uniqKey="Willman C" first="Cheryl L." last="Willman">Cheryl L. Willman</name>
<affiliation wicri:level="2">
<nlm:aff id="af5-1011082">University of New Mexico Cancer Center, Albuquerque, NM, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of New Mexico Cancer Center, Albuquerque, NM</wicri:regionArea>
<placeName>
<region type="state">Nouveau-Mexique</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Stary, Jan" sort="Stary, Jan" uniqKey="Stary J" first="Jan" last="Stary">Jan Stary</name>
<affiliation wicri:level="3">
<nlm:aff id="af1-1011082">CLIP, Department of Pediatric Hematology and Oncology, 2
<sup>nd</sup>
Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea> Faculty of Medicine, Charles University and University Hospital Motol, Prague</wicri:regionArea>
<placeName>
<settlement type="city">Prague</settlement>
<region type="région" nuts="2">Bohême centrale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Trka, Jan" sort="Trka, Jan" uniqKey="Trka J" first="Jan" last="Trka">Jan Trka</name>
<affiliation wicri:level="3">
<nlm:aff id="af1-1011082">CLIP, Department of Pediatric Hematology and Oncology, 2
<sup>nd</sup>
Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea> Faculty of Medicine, Charles University and University Hospital Motol, Prague</wicri:regionArea>
<placeName>
<settlement type="city">Prague</settlement>
<region type="région" nuts="2">Bohême centrale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Zuna, Jan" sort="Zuna, Jan" uniqKey="Zuna J" first="Jan" last="Zuna">Jan Zuna</name>
<affiliation wicri:level="3">
<nlm:aff id="af1-1011082">CLIP, Department of Pediatric Hematology and Oncology, 2
<sup>nd</sup>
Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea> Faculty of Medicine, Charles University and University Hospital Motol, Prague</wicri:regionArea>
<placeName>
<settlement type="city">Prague</settlement>
<region type="région" nuts="2">Bohême centrale</region>
</placeName>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Haematologica</title>
<idno type="ISSN">0390-6078</idno>
<idno type="eISSN">1592-8721</idno>
<imprint>
<date when="2016">2016</date>
</imprint>
</series>
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<front>
<div type="abstract" xml:lang="en">
<p>To characterize the incidence, clinical features and genetics of
<italic>ETV6-ABL1</italic>
leukemias, representing targetable kinase-activating lesions, we analyzed 44 new and published cases of
<italic>ETV6-ABL1</italic>
-positive hematologic malignancies [22 cases of acute lymphoblastic leukemia (13 children, 9 adults) and 22 myeloid malignancies (18 myeloproliferative neoplasms, 4 acute myeloid leukemias)]. The presence of the
<italic>ETV6-ABL1</italic>
fusion was ascertained by cytogenetics, fluorescence
<italic>in-situ</italic>
hybridization, reverse transcriptase-polymerase chain reaction and RNA sequencing. Genomic and gene expression profiling was performed by single nucleotide polymorphism and expression arrays. Systematic screening of more than 4,500 cases revealed that in acute lymphoblastic leukemia
<italic>ETV6-ABL1</italic>
is rare in childhood (0.17% cases) and slightly more common in adults (0.38%). There is no systematic screening of myeloproliferative neoplasms; however, the number of
<italic>ETV6-ABL1</italic>
-positive cases and the relative incidence of acute lymphoblastic leukemia and myeloproliferative neoplasms suggest that in adulthood
<italic>ETV6-ABL1</italic>
is more common in
<italic>BCR-ABL1</italic>
-negative chronic myeloid leukemia-like myeloproliferations than in acute lymphoblastic leukemia. The genomic profile of
<italic>ETV6-ABL1</italic>
acute lymphoblastic leukemia resembled that of
<italic>BCR-ABL1</italic>
and
<italic>BCR-ABL1</italic>
-like cases with 80% of patients having concurrent
<italic>CDKN2A/B</italic>
and
<italic>IKZF1</italic>
deletions. In the gene expression profiling all the
<italic>ETV6-ABL1</italic>
-positive samples clustered in close vicinity to
<italic>BCR-ABL1</italic>
cases. All but one of the cases of
<italic>ETV6-ABL1</italic>
acute lymphoblastic leukemia were classified as
<italic>BCR-ABL1</italic>
-like by a standardized assay. Over 60% of patients died, irrespectively of the disease or age subgroup examined. In conclusion,
<italic>ETV6-ABL1</italic>
fusion occurs in both lymphoid and myeloid leukemias; the genomic profile and clinical behavior resemble
<italic>BCR-ABL1</italic>
-positive malignancies, including the unfavorable prognosis, particularly of acute leukemias. The poor outcome suggests that treatment with tyrosine kinase inhibitors should be considered for patients with this fusion.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article">
<pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">Haematologica</journal-id>
<journal-id journal-id-type="iso-abbrev">Haematologica</journal-id>
<journal-id journal-id-type="hwp">haematol</journal-id>
<journal-id journal-id-type="publisher-id">Haematologica</journal-id>
<journal-title-group>
<journal-title>Haematologica</journal-title>
</journal-title-group>
<issn pub-type="ppub">0390-6078</issn>
<issn pub-type="epub">1592-8721</issn>
<publisher>
<publisher-name>Ferrata Storti Foundation</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">27229714</article-id>
<article-id pub-id-type="pmc">5060025</article-id>
<article-id pub-id-type="doi">10.3324/haematol.2016.144345</article-id>
<article-id pub-id-type="publisher-id">1011082</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Articles</subject>
<subj-group subj-group-type="heading">
<subject>Acute Lymphoblastic Leukemia</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Characterization of leukemias with
<italic>ETV6-ABL1</italic>
fusion</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Zaliova</surname>
<given-names>Marketa</given-names>
</name>
<xref ref-type="aff" rid="af1-1011082">1</xref>
<xref ref-type="corresp" rid="c1-1011082"></xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Moorman</surname>
<given-names>Anthony V.</given-names>
</name>
<xref ref-type="aff" rid="af2-1011082">2</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Cazzaniga</surname>
<given-names>Giovanni</given-names>
</name>
<xref ref-type="aff" rid="af3-1011082">3</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Stanulla</surname>
<given-names>Martin</given-names>
</name>
<xref ref-type="aff" rid="af4-1011082">4</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Harvey</surname>
<given-names>Richard C.</given-names>
</name>
<xref ref-type="aff" rid="af5-1011082">5</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Roberts</surname>
<given-names>Kathryn G.</given-names>
</name>
<xref ref-type="aff" rid="af6-1011082">6</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Heatley</surname>
<given-names>Sue L.</given-names>
</name>
<xref ref-type="aff" rid="af7-1011082">7</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Loh</surname>
<given-names>Mignon L.</given-names>
</name>
<xref ref-type="aff" rid="af8-1011082">8</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Konopleva</surname>
<given-names>Marina</given-names>
</name>
<xref ref-type="aff" rid="af9-1011082">9</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Chen</surname>
<given-names>I-Ming</given-names>
</name>
<xref ref-type="aff" rid="af5-1011082">5</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Zimmermannova</surname>
<given-names>Olga</given-names>
</name>
<xref ref-type="aff" rid="af1-1011082">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Schwab</surname>
<given-names>Claire</given-names>
</name>
<xref ref-type="aff" rid="af2-1011082">2</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Smith</surname>
<given-names>Owen</given-names>
</name>
<xref ref-type="aff" rid="af10-1011082">10</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Mozziconacci</surname>
<given-names>Marie-Joelle</given-names>
</name>
<xref ref-type="aff" rid="af11-1011082">11</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Chabannon</surname>
<given-names>Christian</given-names>
</name>
<xref ref-type="aff" rid="af12-1011082">12</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Kim</surname>
<given-names>Myungshin</given-names>
</name>
<xref ref-type="aff" rid="af13-1011082">13</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Frederik Falkenburg</surname>
<given-names>J. H.</given-names>
</name>
<xref ref-type="aff" rid="af14-1011082">14</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Norton</surname>
<given-names>Alice</given-names>
</name>
<xref ref-type="aff" rid="af15-1011082">15</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Marshall</surname>
<given-names>Karen</given-names>
</name>
<xref ref-type="aff" rid="af16-1011082">16</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Haas</surname>
<given-names>Oskar A.</given-names>
</name>
<xref ref-type="aff" rid="af17-1011082">17</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Starkova</surname>
<given-names>Julia</given-names>
</name>
<xref ref-type="aff" rid="af1-1011082">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Stuchly</surname>
<given-names>Jan</given-names>
</name>
<xref ref-type="aff" rid="af1-1011082">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hunger</surname>
<given-names>Stephen P.</given-names>
</name>
<xref ref-type="aff" rid="af18-1011082">18</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>White</surname>
<given-names>Deborah</given-names>
</name>
<xref ref-type="aff" rid="af7-1011082">7</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Mullighan</surname>
<given-names>Charles G.</given-names>
</name>
<xref ref-type="aff" rid="af6-1011082">6</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Willman</surname>
<given-names>Cheryl L.</given-names>
</name>
<xref ref-type="aff" rid="af5-1011082">5</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Stary</surname>
<given-names>Jan</given-names>
</name>
<xref ref-type="aff" rid="af1-1011082">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Trka</surname>
<given-names>Jan</given-names>
</name>
<xref ref-type="aff" rid="af1-1011082">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Zuna</surname>
<given-names>Jan</given-names>
</name>
<xref ref-type="aff" rid="af1-1011082">1</xref>
<xref ref-type="corresp" rid="c1-1011082"></xref>
</contrib>
</contrib-group>
<aff id="af1-1011082">
<label>1</label>
CLIP, Department of Pediatric Hematology and Oncology, 2
<sup>nd</sup>
Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic</aff>
<aff id="af2-1011082">
<label>2</label>
Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK</aff>
<aff id="af3-1011082">
<label>3</label>
Centro Ricerca Tettamanti, Clinica Pediatrica, Università di Milano-Bicocca, Fondazione MBBM/Ospedale San Gerardo, Monza, Italy</aff>
<aff id="af4-1011082">
<label>4</label>
Pediatric Hematology and Oncology, Hannover Medical School, Germany</aff>
<aff id="af5-1011082">
<label>5</label>
University of New Mexico Cancer Center, Albuquerque, NM, USA</aff>
<aff id="af6-1011082">
<label>6</label>
Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN, USA</aff>
<aff id="af7-1011082">
<label>7</label>
South Australia Health and Medical Research Institute, Adelaide, Australia</aff>
<aff id="af8-1011082">
<label>8</label>
Department of Pediatrics, Hematology-Oncology, Benioff Children’s Hospital, and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA</aff>
<aff id="af9-1011082">
<label>9</label>
Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA</aff>
<aff id="af10-1011082">
<label>10</label>
Department of Haematology, Our Lady’s Children’s Hospital, Dublin, Ireland</aff>
<aff id="af11-1011082">
<label>11</label>
Department of Cancer Biology, Institut Paoli Calmettes, Marseille, France</aff>
<aff id="af12-1011082">
<label>12</label>
Department of Hematology, Institut Paoli Calmettes, Marseille, France</aff>
<aff id="af13-1011082">
<label>13</label>
Department of Laboratory Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea</aff>
<aff id="af14-1011082">
<label>14</label>
Department of Hematology, Leiden University Medical Center, The Netherlands</aff>
<aff id="af15-1011082">
<label>15</label>
Birmingham Children’s Hospital, NHS Foundation Trust, UK</aff>
<aff id="af16-1011082">
<label>16</label>
Department of Cytogenetics, Leicester Royal Infirmary NHS Trust, UK</aff>
<aff id="af17-1011082">
<label>17</label>
St. Anna Children’s Hospital, Childrens Cancer Research Institute, Vienna, Austria</aff>
<aff id="af18-1011082">
<label>18</label>
Department of Pediatrics and the Center for Childhood Cancer Research, Children’s Hospital of Philadelphia and the University of Pennsylvania Perelman School of Medicine, PA, USA</aff>
<author-notes>
<corresp id="c1-1011082">Correspondence:
<email>marketa.zaliova@lfmotol.cuni.cz</email>
or
<email>jan.zuna@lfmotol.cuni.cz</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub">
<month>9</month>
<year>2016</year>
</pub-date>
<volume>101</volume>
<issue>9</issue>
<fpage>1082</fpage>
<lpage>1093</lpage>
<history>
<date date-type="received">
<day>12</day>
<month>2</month>
<year>2016</year>
</date>
<date date-type="accepted">
<day>18</day>
<month>5</month>
<year>2016</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright© Ferrata Storti Foundation</copyright-statement>
<copyright-year>2016</copyright-year>
</permissions>
<self-uri content-type="pdf" xlink:type="simple" xlink:href="1011082.pdf"></self-uri>
<abstract>
<p>To characterize the incidence, clinical features and genetics of
<italic>ETV6-ABL1</italic>
leukemias, representing targetable kinase-activating lesions, we analyzed 44 new and published cases of
<italic>ETV6-ABL1</italic>
-positive hematologic malignancies [22 cases of acute lymphoblastic leukemia (13 children, 9 adults) and 22 myeloid malignancies (18 myeloproliferative neoplasms, 4 acute myeloid leukemias)]. The presence of the
<italic>ETV6-ABL1</italic>
fusion was ascertained by cytogenetics, fluorescence
<italic>in-situ</italic>
hybridization, reverse transcriptase-polymerase chain reaction and RNA sequencing. Genomic and gene expression profiling was performed by single nucleotide polymorphism and expression arrays. Systematic screening of more than 4,500 cases revealed that in acute lymphoblastic leukemia
<italic>ETV6-ABL1</italic>
is rare in childhood (0.17% cases) and slightly more common in adults (0.38%). There is no systematic screening of myeloproliferative neoplasms; however, the number of
<italic>ETV6-ABL1</italic>
-positive cases and the relative incidence of acute lymphoblastic leukemia and myeloproliferative neoplasms suggest that in adulthood
<italic>ETV6-ABL1</italic>
is more common in
<italic>BCR-ABL1</italic>
-negative chronic myeloid leukemia-like myeloproliferations than in acute lymphoblastic leukemia. The genomic profile of
<italic>ETV6-ABL1</italic>
acute lymphoblastic leukemia resembled that of
<italic>BCR-ABL1</italic>
and
<italic>BCR-ABL1</italic>
-like cases with 80% of patients having concurrent
<italic>CDKN2A/B</italic>
and
<italic>IKZF1</italic>
deletions. In the gene expression profiling all the
<italic>ETV6-ABL1</italic>
-positive samples clustered in close vicinity to
<italic>BCR-ABL1</italic>
cases. All but one of the cases of
<italic>ETV6-ABL1</italic>
acute lymphoblastic leukemia were classified as
<italic>BCR-ABL1</italic>
-like by a standardized assay. Over 60% of patients died, irrespectively of the disease or age subgroup examined. In conclusion,
<italic>ETV6-ABL1</italic>
fusion occurs in both lymphoid and myeloid leukemias; the genomic profile and clinical behavior resemble
<italic>BCR-ABL1</italic>
-positive malignancies, including the unfavorable prognosis, particularly of acute leukemias. The poor outcome suggests that treatment with tyrosine kinase inhibitors should be considered for patients with this fusion.</p>
</abstract>
</article-meta>
</front>
</pmc>
<affiliations>
<list>
<country>
<li>Allemagne</li>
<li>Australie</li>
<li>Autriche</li>
<li>Corée du Sud</li>
<li>France</li>
<li>Irlande (pays)</li>
<li>Italie</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>République tchèque</li>
<li>États-Unis</li>
</country>
<region>
<li>Bohême centrale</li>
<li>Californie</li>
<li>Nouveau-Mexique</li>
<li>Pennsylvanie</li>
<li>Provence-Alpes-Côte d'Azur</li>
<li>Région capitale de Séoul</li>
<li>Tennessee</li>
<li>Texas</li>
<li>Vienne (Autriche)</li>
</region>
<settlement>
<li>Marseille</li>
<li>Prague</li>
<li>Séoul</li>
<li>Vienne (Autriche)</li>
</settlement>
</list>
<tree>
<country name="République tchèque">
<region name="Bohême centrale">
<name sortKey="Zaliova, Marketa" sort="Zaliova, Marketa" uniqKey="Zaliova M" first="Marketa" last="Zaliova">Marketa Zaliova</name>
</region>
<name sortKey="Starkova, Julia" sort="Starkova, Julia" uniqKey="Starkova J" first="Julia" last="Starkova">Julia Starkova</name>
<name sortKey="Stary, Jan" sort="Stary, Jan" uniqKey="Stary J" first="Jan" last="Stary">Jan Stary</name>
<name sortKey="Stuchly, Jan" sort="Stuchly, Jan" uniqKey="Stuchly J" first="Jan" last="Stuchly">Jan Stuchly</name>
<name sortKey="Trka, Jan" sort="Trka, Jan" uniqKey="Trka J" first="Jan" last="Trka">Jan Trka</name>
<name sortKey="Zimmermannova, Olga" sort="Zimmermannova, Olga" uniqKey="Zimmermannova O" first="Olga" last="Zimmermannova">Olga Zimmermannova</name>
<name sortKey="Zuna, Jan" sort="Zuna, Jan" uniqKey="Zuna J" first="Jan" last="Zuna">Jan Zuna</name>
</country>
<country name="Royaume-Uni">
<noRegion>
<name sortKey="Moorman, Anthony V" sort="Moorman, Anthony V" uniqKey="Moorman A" first="Anthony V." last="Moorman">Anthony V. Moorman</name>
</noRegion>
<name sortKey="Marshall, Karen" sort="Marshall, Karen" uniqKey="Marshall K" first="Karen" last="Marshall">Karen Marshall</name>
<name sortKey="Norton, Alice" sort="Norton, Alice" uniqKey="Norton A" first="Alice" last="Norton">Alice Norton</name>
<name sortKey="Schwab, Claire" sort="Schwab, Claire" uniqKey="Schwab C" first="Claire" last="Schwab">Claire Schwab</name>
</country>
<country name="Italie">
<noRegion>
<name sortKey="Cazzaniga, Giovanni" sort="Cazzaniga, Giovanni" uniqKey="Cazzaniga G" first="Giovanni" last="Cazzaniga">Giovanni Cazzaniga</name>
</noRegion>
</country>
<country name="Allemagne">
<noRegion>
<name sortKey="Stanulla, Martin" sort="Stanulla, Martin" uniqKey="Stanulla M" first="Martin" last="Stanulla">Martin Stanulla</name>
</noRegion>
</country>
<country name="États-Unis">
<region name="Nouveau-Mexique">
<name sortKey="Harvey, Richard C" sort="Harvey, Richard C" uniqKey="Harvey R" first="Richard C." last="Harvey">Richard C. Harvey</name>
</region>
<name sortKey="Chen, I Ming" sort="Chen, I Ming" uniqKey="Chen I" first="I-Ming" last="Chen">I-Ming Chen</name>
<name sortKey="Hunger, Stephen P" sort="Hunger, Stephen P" uniqKey="Hunger S" first="Stephen P." last="Hunger">Stephen P. Hunger</name>
<name sortKey="Konopleva, Marina" sort="Konopleva, Marina" uniqKey="Konopleva M" first="Marina" last="Konopleva">Marina Konopleva</name>
<name sortKey="Loh, Mignon L" sort="Loh, Mignon L" uniqKey="Loh M" first="Mignon L." last="Loh">Mignon L. Loh</name>
<name sortKey="Mullighan, Charles G" sort="Mullighan, Charles G" uniqKey="Mullighan C" first="Charles G." last="Mullighan">Charles G. Mullighan</name>
<name sortKey="Roberts, Kathryn G" sort="Roberts, Kathryn G" uniqKey="Roberts K" first="Kathryn G." last="Roberts">Kathryn G. Roberts</name>
<name sortKey="Willman, Cheryl L" sort="Willman, Cheryl L" uniqKey="Willman C" first="Cheryl L." last="Willman">Cheryl L. Willman</name>
</country>
<country name="Australie">
<noRegion>
<name sortKey="Heatley, Sue L" sort="Heatley, Sue L" uniqKey="Heatley S" first="Sue L." last="Heatley">Sue L. Heatley</name>
</noRegion>
<name sortKey="White, Deborah" sort="White, Deborah" uniqKey="White D" first="Deborah" last="White">Deborah White</name>
</country>
<country name="Irlande (pays)">
<noRegion>
<name sortKey="Smith, Owen" sort="Smith, Owen" uniqKey="Smith O" first="Owen" last="Smith">Owen Smith</name>
</noRegion>
</country>
<country name="France">
<region name="Provence-Alpes-Côte d'Azur">
<name sortKey="Mozziconacci, Marie Joelle" sort="Mozziconacci, Marie Joelle" uniqKey="Mozziconacci M" first="Marie-Joelle" last="Mozziconacci">Marie-Joelle Mozziconacci</name>
</region>
<name sortKey="Chabannon, Christian" sort="Chabannon, Christian" uniqKey="Chabannon C" first="Christian" last="Chabannon">Christian Chabannon</name>
</country>
<country name="Corée du Sud">
<region name="Région capitale de Séoul">
<name sortKey="Kim, Myungshin" sort="Kim, Myungshin" uniqKey="Kim M" first="Myungshin" last="Kim">Myungshin Kim</name>
</region>
</country>
<country name="Pays-Bas">
<noRegion>
<name sortKey="Frederik Falkenburg, J H" sort="Frederik Falkenburg, J H" uniqKey="Frederik Falkenburg J" first="J. H." last="Frederik Falkenburg">J. H. Frederik Falkenburg</name>
</noRegion>
</country>
<country name="Autriche">
<region name="Vienne (Autriche)">
<name sortKey="Haas, Oskar A" sort="Haas, Oskar A" uniqKey="Haas O" first="Oskar A." last="Haas">Oskar A. Haas</name>
</region>
</country>
</tree>
</affiliations>
</record>

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