Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
Identifieur interne : 000917 ( Pmc/Checkpoint ); précédent : 000916; suivant : 000918Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
Auteurs : Cristian Pattaro [Italie] ; Alexander Teumer [Allemagne] ; Mathias Gorski [Allemagne] ; Audrey Y. Chu [États-Unis] ; Man Li [États-Unis] ; Vladan Mijatovic [Italie] ; Maija Garnaas [États-Unis] ; Adrienne Tin [États-Unis] ; Rossella Sorice [Italie] ; Yong Li [Allemagne] ; Daniel Taliun [Italie] ; Matthias Olden [Allemagne] ; Meredith Foster [États-Unis] ; Qiong Yang [États-Unis] ; Ming-Huei Chen [États-Unis] ; Tune H. Pers [États-Unis] ; Andrew D. Johnson [États-Unis] ; Yi-An Ko [États-Unis] ; Christian Fuchsberger [Italie] ; Bamidele Tayo [États-Unis] ; Michael Nalls [États-Unis] ; Mary F. Feitosa [États-Unis] ; Aaron Isaacs [Pays-Bas] ; Abbas Dehghan [Pays-Bas] ; Pio D'Adamo [Italie] ; Adebowale Adeyemo [États-Unis] ; Aida Karina Dieffenbach [Allemagne] ; Alan B. Zonderman [États-Unis] ; Ilja M. Nolte [Pays-Bas] ; Peter J. Van Der Most [Pays-Bas] ; Alan F. Wright [Royaume-Uni] ; Alan R. Shuldiner [États-Unis] ; Alanna C. Morrison [États-Unis] ; Albert Hofman [Pays-Bas] ; Albert V. Smith [Islande] ; Albert W. Dreisbach [États-Unis] ; Andre Franke [Allemagne] ; Andre G. Uitterlinden [Pays-Bas] ; Andres Metspalu [Estonie] ; Anke Tonjes [Allemagne] ; Antonio Lupo [Italie] ; Antonietta Robino [Italie] ; Sa Johansson [Suède] ; Ayse Demirkan [Pays-Bas] ; Barbara Kollerits [Autriche] ; Barry I. Freedman [États-Unis] ; Belen Ponte [Suisse] ; Ben A. Oostra [Pays-Bas] ; Bernhard Paulweber [Autriche] ; Bernhard K. Kr Mer [Allemagne] ; Braxton D. Mitchell [États-Unis] ; Brendan M. Buckley [Irlande (pays)] ; Carmen A. Peralta [États-Unis] ; Caroline Hayward [Royaume-Uni] ; Catherine Helmer [France] ; Charles N. Rotimi [États-Unis] ; Christian M. Shaffer [États-Unis] ; Christian Müller [Allemagne] ; Cinzia Sala [Italie] ; Cornelia M. Van Duijn [Pays-Bas] ; Aude Saint-Pierre [Italie, France] ; Daniel Ackermann [Suisse] ; Daniel Shriner [États-Unis] ; Daniela Ruggiero [Italie] ; Daniela Toniolo [Italie] ; Yingchang Lu [États-Unis] ; Daniele Cusi [Italie] ; Darina Czamara [Allemagne] ; David Ellinghaus [Allemagne] ; David S. Siscovick [États-Unis] ; Douglas Ruderfer [États-Unis] ; Christian Gieger [Allemagne] ; Harald Grallert [Allemagne] ; Elena Rochtchina [Australie] ; Elizabeth J. Atkinson [États-Unis] ; Elizabeth G. Holliday [Australie] ; Eric Boerwinkle [États-Unis] ; Erika Salvi [Italie] ; Erwin P. Bottinger [États-Unis] ; Federico Murgia [Italie] ; Fernando Rivadeneira [Pays-Bas] ; Florian Ernst [Allemagne] ; Florian Kronenberg [Autriche] ; Frank B. Hu [États-Unis] ; Gerjan J. Navis [Pays-Bas] ; Gary C. Curhan [États-Unis] ; George B. Ehret [Suisse] ; Georg Homuth [Allemagne] ; Stefan Coassin [Autriche] ; Gian-Andri Thun [Suisse] ; Giorgio Pistis [Italie] ; Giovanni Gambaro [Italie] ; Giovanni Malerba [Italie] ; Grant W. Montgomery [Australie] ; Gudny Eiriksdottir [Islande] ; Gunnar Jacobs [Allemagne] ; Guo Li [États-Unis] ; H-Erich Wichmann [Allemagne] ; Harry Campbell [Royaume-Uni] ; Helena Schmidt [Autriche] ; Henri Wallaschofski [Allemagne] ; Henry Völzke [Allemagne] ; Hermann Brenner [Allemagne] ; Heyo K. Kroemer [Allemagne] ; Holly Kramer [États-Unis] ; Honghuang Lin [États-Unis] ; I. Mateo Leach [Pays-Bas] ; Ian Ford [Royaume-Uni] ; Idris Guessous [Suisse, États-Unis] ; Igor Rudan [Royaume-Uni] ; Inga Prokopenko [Royaume-Uni] ; Ingrid Borecki [États-Unis] ; Iris M. Heid [Allemagne] ; Ivana Kolcic [Croatie] ; Ivana Persico [Italie] ; J. Wouter Jukema [Pays-Bas] ; James F. Wilson [Royaume-Uni] ; Janine F. Felix [Pays-Bas] ; Jasmin Divers [États-Unis] ; Jean-Charles Lambert [France] ; Jeanette M. Stafford [États-Unis] ; Jean-Michel Gaspoz [Suisse] ; Jennifer A. Smith [États-Unis] ; Jessica D. Faul [États-Unis] ; Jie Jin Wang [Australie] ; Jingzhong Ding [États-Unis] ; Joel N. Hirschhorn [États-Unis] ; John Attia [États-Unis, Australie] ; John B. Whitfield [Australie] ; John Chalmers [Australie] ; Jorma Viikari [Finlande] ; Josef Coresh [États-Unis] ; Joshua C. Denny [États-Unis] ; Juha Karjalainen [Pays-Bas] ; Jyotika K. Fernandes [États-Unis] ; Karlhans Endlich [Allemagne] ; Katja Butterbach [Allemagne] ; Keith L. Keene [États-Unis] ; Kurt Lohman [États-Unis] ; Laura Portas [Italie] ; Lenore J. Launer [États-Unis] ; Leo-Pekka Lyytik Inen [Finlande] ; Loic Yengo [France] ; Lude Franke [Pays-Bas] ; Luigi Ferrucci [États-Unis] ; Lynda M. Rose [États-Unis] ; Lyudmyla Kedenko [Autriche] ; Madhumathi Rao [États-Unis] ; Maksim Struchalin [Pays-Bas] ; Marcus E. Kleber [Allemagne] ; Margherita Cavalieri [Autriche] ; Margot Haun [Autriche] ; Marilyn C. Cornelis [États-Unis] ; Marina Ciullo [Italie] ; Mario Pirastu [Italie] ; Mariza De Andrade [États-Unis] ; Mark A. Mcevoy [Australie] ; Mark Woodward [États-Unis, Australie, Finlande, Royaume-Uni] ; Martin Adam [Suisse] ; Massimiliano Cocca [Italie] ; Matthias Nauck [Allemagne] ; Medea Imboden [Suisse] ; Melanie Waldenberger [Allemagne] ; Menno Pruijm [Suisse] ; Marie Metzger [France] ; Michael Stumvoll [Allemagne] ; Michele K. Evans [États-Unis] ; Michele M. Sale [États-Unis] ; Mika K Hönen [Finlande] ; Mladen Boban [Croatie] ; Murielle Bochud [Suisse] ; Myriam Rheinberger [Allemagne] ; Niek Verweij [Pays-Bas] ; Nabila Bouatia-Naji [France] ; Nicholas G. Martin [Australie, États-Unis] ; Nick Hastie [Royaume-Uni] ; Nicole Probst-Hensch [Suisse] ; Nicole Soranzo [Royaume-Uni] ; Olivier Devuyst [Suisse] ; Olli Raitakari [Finlande] ; Omri Gottesman [États-Unis] ; Oscar H. Franco [Pays-Bas] ; Ozren Polasek [Croatie] ; Paolo Gasparini [Italie] ; Patricia B. Munroe [Royaume-Uni] ; Paul M. Ridker [États-Unis] ; Paul Mitchell [Australie] ; Paul Muntner [États-Unis] ; Christa Meisinger [Allemagne] ; Johannes H. Smit [Pays-Bas] ; Peter Kovacs [Allemagne] ; Philipp S. Wild [Allemagne] ; Philippe Froguel [France] ; Rainer Rettig [Allemagne] ; Reedik M Gi [Estonie] ; Reiner Biffar [Allemagne] ; Reinhold Schmidt [Autriche] ; Rita P. S. Middelberg [Australie] ; Robert J. Carroll [États-Unis] ; Brenda W. Penninx [Pays-Bas] ; Rodney J. Scott [Australie] ; Ronit Katz [États-Unis] ; Sanaz Sedaghat [Pays-Bas] ; Sarah H. Wild [Royaume-Uni] ; Sharon L. R. Kardia [États-Unis] ; Sheila Ulivi [Italie] ; Shih-Jen Hwang [États-Unis] ; Stefan Enroth [Suède] ; Stefan Kloiber [Allemagne] ; Stella Trompet [Pays-Bas] ; Benedicte Stengel [France] ; Stephen J. Hancock [Australie] ; Stephen T. Turner [États-Unis] ; Sylvia E. Rosas [États-Unis] ; Sylvia Stracke [France, Allemagne] ; Tamara B. Harris [États-Unis] ; Tanja Zeller [Allemagne] ; Tatijana Zemunik [Croatie] ; Terho Lehtim Ki [Finlande] ; Thomas Illig [Allemagne] ; Thor Aspelund [Islande] ; Tiit Nikopensius [Estonie] ; Tonu Esko [États-Unis, Estonie] ; Toshiko Tanaka [États-Unis] ; Ulf Gyllensten [Suède] ; Uwe Völker [Allemagne] ; Valur Emilsson [Islande] ; Veronique Vitart [Royaume-Uni] ; Ville Aalto [Finlande] ; Vilmundur Gudnason [Islande] ; Vincent Chouraki [France] ; Wei-Min Chen [États-Unis] ; Wilmar Igl [Suède] ; Winfried M Rz [Allemagne] ; Wolfgang Koenig [Allemagne] ; Wolfgang Lieb [Allemagne] ; Ruth J. F. Loos [États-Unis] ; Yongmei Liu [États-Unis] ; Harold Snieder [Pays-Bas] ; Peter P. Pramstaller [Italie, Allemagne] ; Afshin Parsa [États-Unis] ; Jeffrey R. O'Connell [États-Unis] ; Katalin Susztak [États-Unis] ; Pavel Hamet [Canada] ; Johanne Tremblay [Canada] ; Ian H. De Boer [États-Unis] ; Carsten A. Böger [Allemagne] ; Wolfram Goessling [États-Unis] ; Daniel I. Chasman [États-Unis] ; Anna Köttgen [États-Unis, Allemagne] ; W. H. Linda Kao [États-Unis] ; Caroline S. Fox [États-Unis]Source :
- Nature Communications [ 2041-1723 ] ; 2016.
Abstract
Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways.
Url:
DOI: 10.1038/ncomms10023
PubMed: 26831199
PubMed Central: 4735748
Affiliations:
- Allemagne, Australie, Autriche, Canada, Croatie, Estonie, Finlande, France, Irlande (pays), Islande, Italie, Pays-Bas, Royaume-Uni, Suisse, Suède, États-Unis
- Hambourg
- Hambourg
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PMC:4735748Le document en format XML
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Pers</name><affiliation wicri:level="1"><nlm:aff id="a15"><institution>Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital</institution>, 300 Longwood Avenue, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a16"><institution>Medical and Population Genetics Program, Broad Institute of MIT and Harvard</institution>, Cambridge, Massachusetts 2142,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Johnson, Andrew D" sort="Johnson, Andrew D" uniqKey="Johnson A" first="Andrew D." last="Johnson">Andrew D. Johnson</name><affiliation wicri:level="1"><nlm:aff id="a17"><institution>NHLBI's Framingham Heart Study and the Center for Population Studies</institution>, 73 Mt Wayte Avenue, Suite 2, Framingham, Massachusetts 01702,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ko, Yi An" sort="Ko, Yi An" uniqKey="Ko Y" first="Yi-An" last="Ko">Yi-An Ko</name><affiliation wicri:level="1"><nlm:aff id="a18"><institution>Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania</institution>, 415 Curie Boulevard, 405B Clinical Research Building, Philadelphia, Pennsylvania 19104-4539,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fuchsberger, Christian" sort="Fuchsberger, Christian" uniqKey="Fuchsberger C" first="Christian" last="Fuchsberger">Christian Fuchsberger</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck</institution>, Via Galvani 31, Bolzano 39100,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tayo, Bamidele" sort="Tayo, Bamidele" uniqKey="Tayo B" first="Bamidele" last="Tayo">Bamidele Tayo</name><affiliation wicri:level="1"><nlm:aff id="a19"><institution>Department of Public Health Sciences, Loyola Medical Center</institution>, 2160 S First Avenue, Maywood, Illinois 60153,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nalls, Michael" sort="Nalls, Michael" uniqKey="Nalls M" first="Michael" last="Nalls">Michael Nalls</name><affiliation wicri:level="1"><nlm:aff id="a20"><institution>Laboratory of Neurogenetics</institution>, Building 35—Porter Building, 1A1015, National Institute on Aging/NIH, Bethesda, Maryland 20892,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Feitosa, Mary F" sort="Feitosa, Mary F" uniqKey="Feitosa M" first="Mary F." last="Feitosa">Mary F. Feitosa</name><affiliation wicri:level="1"><nlm:aff id="a21"><institution>Division of Statistical Genomics, Washington University School of Medicine</institution>, 4444 Forest Park Boulevard, Box 8506, St Louis, Missouri 63108,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Isaacs, Aaron" sort="Isaacs, Aaron" uniqKey="Isaacs A" first="Aaron" last="Isaacs">Aaron Isaacs</name><affiliation wicri:level="1"><nlm:aff id="a22"><institution>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center</institution>, Dr Molewaterplein 50, PO Box 2040, Rotterdam 3000 CA,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a23"><institution>Centre for Medical Systems Biology Leiden</institution>, Dr Molewaterplein 50, PO Box 2040, Rotterdam 3000 CA,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name><affiliation wicri:level="1"><nlm:aff id="a24"><institution>Department of Epidemiology, Erasmus University Medical Center</institution>, PO Box 2040, Rotterdam 3000 CA,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="D Adamo, Pio" sort="D Adamo, Pio" uniqKey="D Adamo P" first="Pio" last="D'Adamo">Pio D'Adamo</name><affiliation wicri:level="1"><nlm:aff id="a25"><institution>Institute for Maternal and Child Health—IRCCS "Burlo Garofolo" and University of Trieste</institution>, via dell'Istria 65/1, Trieste 34137,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Adeyemo, Adebowale" sort="Adeyemo, Adebowale" uniqKey="Adeyemo A" first="Adebowale" last="Adeyemo">Adebowale Adeyemo</name><affiliation wicri:level="1"><nlm:aff id="a26"><institution>Center for Research on Genomics and Global Health, National Human Genome Research Institute</institution>, Building 12A, Room 4047, 12 South Dr, MSC 5635, Bethesda, Maryland 20892-5635,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dieffenbach, Aida Karina" sort="Dieffenbach, Aida Karina" uniqKey="Dieffenbach A" first="Aida Karina" last="Dieffenbach">Aida Karina Dieffenbach</name><affiliation wicri:level="1"><nlm:aff id="a27"><institution>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)</institution>, Im Neuenheimer Feld 581, Heidelberg 69120,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a28"><institution>German Cancer Consortium (DKTK)</institution>, Im Neuenheimer Feld 581, Heidelberg 69120,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zonderman, Alan B" sort="Zonderman, Alan B" uniqKey="Zonderman A" first="Alan B." last="Zonderman">Alan B. Zonderman</name><affiliation wicri:level="1"><nlm:aff id="a29"><institution>Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, NIH Biomedical Center</institution>, 251 Bayview Boulevard, Suite 100, Baltimore, Maryland 21224,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nolte, Ilja M" sort="Nolte, Ilja M" uniqKey="Nolte I" first="Ilja M." last="Nolte">Ilja M. Nolte</name><affiliation wicri:level="1"><nlm:aff id="a30"><institution>Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen</institution>, PO Box 30001, Groningen 9700 RB,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Most, Peter J" sort="Van Der Most, Peter J" uniqKey="Van Der Most P" first="Peter J." last="Van Der Most">Peter J. Van Der Most</name><affiliation wicri:level="1"><nlm:aff id="a30"><institution>Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen</institution>, PO Box 30001, Groningen 9700 RB,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F." last="Wright">Alan F. Wright</name><affiliation wicri:level="1"><nlm:aff id="a31"><institution>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>, Crewe Road, Edinburgh EH4 2XU,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R." last="Shuldiner">Alan R. Shuldiner</name><affiliation wicri:level="1"><nlm:aff id="a32"><institution>Department of Medicine, University of Maryland School of Medicine</institution>, 685 West Baltimore Street, Baltimore, Maryland 21201,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a33"><institution>Geriatric Research and Education Clinical Center, Veterans Administration Medical Center</institution>, 10 North Greene Street, Baltimore, Maryland 21201,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Morrison, Alanna C" sort="Morrison, Alanna C" uniqKey="Morrison A" first="Alanna C." last="Morrison">Alanna C. Morrison</name><affiliation wicri:level="1"><nlm:aff id="a34"><institution>Human Genetics Center, University of Texas Health Science Center at Houston</institution>, 1200 Pressler St Suite 453E, Houston, Texas 77030,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="1"><nlm:aff id="a24"><institution>Department of Epidemiology, Erasmus University Medical Center</institution>, PO Box 2040, Rotterdam 3000 CA,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V." last="Smith">Albert V. Smith</name><affiliation wicri:level="1"><nlm:aff id="a35"><institution>Icelandic Heart Association, Research Institute</institution>, Holtasmari 1, Kopavogur 201,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a36"><institution>University of Iceland</institution>, Sæmundargötu 2, Reykjavik 101,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dreisbach, Albert W" sort="Dreisbach, Albert W" uniqKey="Dreisbach A" first="Albert W." last="Dreisbach">Albert W. Dreisbach</name><affiliation wicri:level="1"><nlm:aff id="a37"><institution>Division of Nephrology, University of Mississippi</institution>, 2500 North State Street, Jackson, Mississippi 39216,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Franke, Andre" sort="Franke, Andre" uniqKey="Franke A" first="Andre" last="Franke">Andre Franke</name><affiliation wicri:level="1"><nlm:aff id="a38"><institution>Institute of Clinical Molecular Biology, Christian-Albrechts University of Kiel</institution>, Schittenhelmstraße 12, Kiel 24105,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><affiliation wicri:level="1"><nlm:aff id="a39"><institution>Department of Internal Medicine, Erasmus University Medical Center</institution>, PO Box 1738, Rotterdam 3000 DR,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation wicri:level="1"><nlm:aff id="a40"><institution>Estonian Genome Center of University of Tartu (EGCUT)</institution>, Riia 23B, Tartu 51010,<country>Estonia</country></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a41"><institution>Institute of Molecular and Cell Biology, University of Tartu and Estonian Biocenter</institution>, Riia 23, Tartu 51010,<country>Estonia</country></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tonjes, Anke" sort="Tonjes, Anke" uniqKey="Tonjes A" first="Anke" last="Tonjes">Anke Tonjes</name><affiliation wicri:level="1"><nlm:aff id="a42"><institution>Department of Medicine, University of Leipzig</institution>, Liebigstraße 18, Leipzig 04103,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lupo, Antonio" sort="Lupo, Antonio" uniqKey="Lupo A" first="Antonio" last="Lupo">Antonio Lupo</name><affiliation wicri:level="1"><nlm:aff id="a43"><institution>Division of Nephrology, Department of Medicine, University of Verona</institution>, Piazzale Aristide Stefani 1, Verona 37126,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Robino, Antonietta" sort="Robino, Antonietta" uniqKey="Robino A" first="Antonietta" last="Robino">Antonietta Robino</name><affiliation wicri:level="1"><nlm:aff id="a25"><institution>Institute for Maternal and Child Health—IRCCS "Burlo Garofolo" and University of Trieste</institution>, via dell'Istria 65/1, Trieste 34137,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name><affiliation wicri:level="1"><nlm:aff id="a44"><institution>Uppsala University, Department of Immunology, Genetics and Pathology, Biomedical Center, SciLifeLab, Uppsala University</institution>, Uppsala SE- 75108,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Demirkan, Ayse" sort="Demirkan, Ayse" uniqKey="Demirkan A" first="Ayse" last="Demirkan">Ayse Demirkan</name><affiliation wicri:level="1"><nlm:aff id="a22"><institution>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center</institution>, Dr Molewaterplein 50, PO Box 2040, Rotterdam 3000 CA,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kollerits, Barbara" sort="Kollerits, Barbara" uniqKey="Kollerits B" first="Barbara" last="Kollerits">Barbara Kollerits</name><affiliation wicri:level="1"><nlm:aff id="a45"><institution>Innsbruck Medical University, Division of Genetic Epidemiology</institution>, Schoepfstraße 41, Innsbruck 6020,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Freedman, Barry I" sort="Freedman, Barry I" uniqKey="Freedman B" first="Barry I." last="Freedman">Barry I. Freedman</name><affiliation wicri:level="1"><nlm:aff id="a46"><institution>Internal Medicine Department, Wake Forest School of Medicine</institution>, Medical Center Boulevard, Winston-Salem, North Carolina 27157-1053,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ponte, Belen" sort="Ponte, Belen" uniqKey="Ponte B" first="Belen" last="Ponte">Belen Ponte</name><affiliation wicri:level="1"><nlm:aff id="a47"><institution>Nephrology Division, Department of Specialties of Internal Medicine, Geneva University Hospital</institution>, 4 rue Gabrielle-Perret-Gentil, Geneve 1211,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name><affiliation wicri:level="1"><nlm:aff id="a48"><institution>Department of Clinical Genetics, Erasmus University Medical Center</institution>, Dr Molewaterplein 50, PO Box 2040, Rotterdam 3000 CA,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Paulweber, Bernhard" sort="Paulweber, Bernhard" uniqKey="Paulweber B" first="Bernhard" last="Paulweber">Bernhard Paulweber</name><affiliation wicri:level="1"><nlm:aff id="a49"><institution>First Department of Internal Medicine, Paracelsus Medical University/Salzburger Landeskliniken</institution>, Müllner Hauptstraße 48, Salzburg 5020,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kr Mer, Bernhard K" sort="Kr Mer, Bernhard K" uniqKey="Kr Mer B" first="Bernhard K." last="Kr Mer">Bernhard K. Kr Mer</name><affiliation wicri:level="1"><nlm:aff id="a50"><institution>University Medical Centre Mannheim, 5th Department of Medicine, University of Heidelberg</institution>, Theodor Kutzer Ufer 1-3, Mannheim 68167,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name><affiliation wicri:level="1"><nlm:aff id="a32"><institution>Department of Medicine, University of Maryland School of Medicine</institution>, 685 West Baltimore Street, Baltimore, Maryland 21201,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a33"><institution>Geriatric Research and Education Clinical Center, Veterans Administration Medical Center</institution>, 10 North Greene Street, Baltimore, Maryland 21201,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Buckley, Brendan M" sort="Buckley, Brendan M" uniqKey="Buckley B" first="Brendan M." last="Buckley">Brendan M. Buckley</name><affiliation wicri:level="1"><nlm:aff id="a51"><institution>Department of Pharmacology and Therapeutics, University College Cork, Clinical Investigations Building</institution>, Western Rd, Cork,<country>Ireland</country></nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peralta, Carmen A" sort="Peralta, Carmen A" uniqKey="Peralta C" first="Carmen A." last="Peralta">Carmen A. Peralta</name><affiliation wicri:level="1"><nlm:aff id="a52"><institution>Division of Nephrology, University of California, San Francisco Medical School and San Francisco VA Medical Center</institution>, 4150 Clement Street, San Francisco, California 94121,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation wicri:level="1"><nlm:aff id="a31"><institution>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>, Crewe Road, Edinburgh EH4 2XU,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Helmer, Catherine" sort="Helmer, Catherine" uniqKey="Helmer C" first="Catherine" last="Helmer">Catherine Helmer</name><affiliation wicri:level="1"><nlm:aff id="a53"><institution>INSERM, ISPED, Centre INSERM U897—Epidemiologie-Biostatistique</institution>, Bordeaux F-33000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a54"><institution>Université Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique</institution>, Bordeaux F-33000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rotimi, Charles N" sort="Rotimi, Charles N" uniqKey="Rotimi C" first="Charles N." last="Rotimi">Charles N. Rotimi</name><affiliation wicri:level="1"><nlm:aff id="a26"><institution>Center for Research on Genomics and Global Health, National Human Genome Research Institute</institution>, Building 12A, Room 4047, 12 South Dr, MSC 5635, Bethesda, Maryland 20892-5635,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shaffer, Christian M" sort="Shaffer, Christian M" uniqKey="Shaffer C" first="Christian M." last="Shaffer">Christian M. Shaffer</name><affiliation wicri:level="1"><nlm:aff id="a55"><institution>Vanderbilt University School of Medicine</institution>, 2215-B Garland Avenue 1224—MRB4 (Light Hall)Nashville, Tennessee 37232,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Muller, Christian" sort="Muller, Christian" uniqKey="Muller C" first="Christian" last="Müller">Christian Müller</name><affiliation wicri:level="1"><nlm:aff id="a56"><institution>University Heart Center Hamburg, Clinic for general and interventional cardiology</institution>, Martinistraße 52, Hamburg 20246,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a57"><institution>German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Lübeck/Kiel</institution>, Martinistraße 52, Hamburg 20246, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>, Martinistraße 52, Hamburg 20246</wicri:regionArea><wicri:noRegion>20246</wicri:noRegion><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Sala, Cinzia" sort="Sala, Cinzia" uniqKey="Sala C" first="Cinzia" last="Sala">Cinzia Sala</name><affiliation wicri:level="1"><nlm:aff id="a58"><institution>Division of Genetics and Cell Biology, San Raffaele Scientific Institute</institution>, Via Olgettina 58, Milano 20132,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><affiliation wicri:level="1"><nlm:aff id="a22"><institution>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center</institution>, Dr Molewaterplein 50, PO Box 2040, Rotterdam 3000 CA,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Saint Pierre, Aude" sort="Saint Pierre, Aude" uniqKey="Saint Pierre A" first="Aude" last="Saint-Pierre">Aude Saint-Pierre</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck</institution>, Via Galvani 31, Bolzano 39100,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a59"><institution>INSERM U1078, Etablissement Français du Sang</institution>, 46 rue Félix Le Dantec, CS 51819, Brest Cedex 2 29218,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ackermann, Daniel" sort="Ackermann, Daniel" uniqKey="Ackermann D" first="Daniel" last="Ackermann">Daniel Ackermann</name><affiliation wicri:level="1"><nlm:aff id="a47"><institution>Nephrology Division, Department of Specialties of Internal Medicine, Geneva University Hospital</institution>, 4 rue Gabrielle-Perret-Gentil, Geneve 1211,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shriner, Daniel" sort="Shriner, Daniel" uniqKey="Shriner D" first="Daniel" last="Shriner">Daniel Shriner</name><affiliation wicri:level="1"><nlm:aff id="a26"><institution>Center for Research on Genomics and Global Health, National Human Genome Research Institute</institution>, Building 12A, Room 4047, 12 South Dr, MSC 5635, Bethesda, Maryland 20892-5635,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ruggiero, Daniela" sort="Ruggiero, Daniela" uniqKey="Ruggiero D" first="Daniela" last="Ruggiero">Daniela Ruggiero</name><affiliation wicri:level="1"><nlm:aff id="a10"><institution>Institute of Genetics and Biophysics "Adriano Buzzati-Traverso"—CNR</institution>, Via P. Castellino 111, Napoli 80131,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Toniolo, Daniela" sort="Toniolo, Daniela" uniqKey="Toniolo D" first="Daniela" last="Toniolo">Daniela Toniolo</name><affiliation wicri:level="1"><nlm:aff id="a58"><institution>Division of Genetics and Cell Biology, San Raffaele Scientific Institute</institution>, Via Olgettina 58, Milano 20132,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a60"><institution>Institute of Molecular Genetics-CNR</institution>, Via Abbiategrasso 207, Pavia 27100,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lu, Yingchang" sort="Lu, Yingchang" uniqKey="Lu Y" first="Yingchang" last="Lu">Yingchang Lu</name><affiliation wicri:level="1"><nlm:aff id="a61"><institution>The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai</institution>, New York, New York 10029,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cusi, Daniele" sort="Cusi, Daniele" uniqKey="Cusi D" first="Daniele" last="Cusi">Daniele Cusi</name><affiliation wicri:level="1"><nlm:aff id="a62"><institution>Department of Health Sciences, University of Milano</institution>, Via Antonio di Rudinì 8, Milano 20142,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Czamara, Darina" sort="Czamara, Darina" uniqKey="Czamara D" first="Darina" last="Czamara">Darina Czamara</name><affiliation wicri:level="1"><nlm:aff id="a63"><institution>Max Planck Institute of Psychiatry</institution>, Kraepelinstraße 2–10, Munich 80804,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ellinghaus, David" sort="Ellinghaus, David" uniqKey="Ellinghaus D" first="David" last="Ellinghaus">David Ellinghaus</name><affiliation wicri:level="1"><nlm:aff id="a38"><institution>Institute of Clinical Molecular Biology, Christian-Albrechts University of Kiel</institution>, Schittenhelmstraße 12, Kiel 24105,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S." last="Siscovick">David S. Siscovick</name><affiliation wicri:level="1"><nlm:aff id="a64"><institution>Cardiovascular Health Research Unit, Departments of Epidemiology and Medicine, University of Washington</institution>, 1730 Minor Ave, Suite 1360, Seattle, Washington 98101,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ruderfer, Douglas" sort="Ruderfer, Douglas" uniqKey="Ruderfer D" first="Douglas" last="Ruderfer">Douglas Ruderfer</name><affiliation wicri:level="1"><nlm:aff id="a65"><institution>Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai</institution>, New York, New York 10029,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation wicri:level="1"><nlm:aff id="a66"><institution>Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health</institution>, Ingolstaedter Landstraße 1, 85764 Neuherberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Grallert, Harald" sort="Grallert, Harald" uniqKey="Grallert H" first="Harald" last="Grallert">Harald Grallert</name><affiliation wicri:level="1"><nlm:aff id="a67"><institution>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health</institution>, Ingolstaedter Landstraße 1, 85764 Neuherberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a68"><institution>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health</institution>, 85764 Neuherberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a69"><institution>German Center for Diabetes Research (DZD)</institution>, Ingolstaedter Landstraße 1, Neuherberg 85764,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rochtchina, Elena" sort="Rochtchina, Elena" uniqKey="Rochtchina E" first="Elena" last="Rochtchina">Elena Rochtchina</name><affiliation wicri:level="1"><nlm:aff id="a70"><institution>Westmead Millennium Institute, Centre for Vision Research, University of Sydney</institution>, C24 Westmead Hospital, New South Wales 2145,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Atkinson, Elizabeth J" sort="Atkinson, Elizabeth J" uniqKey="Atkinson E" first="Elizabeth J." last="Atkinson">Elizabeth J. Atkinson</name><affiliation wicri:level="1"><nlm:aff id="a71"><institution>Division of Biomedical Statistics and Informatics, Mayo Clinic</institution>, 200 First Street SW, Rochester, Minnesota 55905,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name><affiliation wicri:level="1"><nlm:aff id="a72"><institution>Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, HMRI Building1, Kookaburra Circuit</institution>, New Lambton New South Wales 2305,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a73"><institution>Clinical Research Design, Information Technology and Statistical Support, Hunter Medical Research Institute, Newcastle</institution>, 1 Kookaburra Circuit, New Lambton Heights, New South Wales 2305,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation wicri:level="1"><nlm:aff id="a34"><institution>Human Genetics Center, University of Texas Health Science Center at Houston</institution>, 1200 Pressler St Suite 453E, Houston, Texas 77030,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Salvi, Erika" sort="Salvi, Erika" uniqKey="Salvi E" first="Erika" last="Salvi">Erika Salvi</name><affiliation wicri:level="1"><nlm:aff id="a62"><institution>Department of Health Sciences, University of Milano</institution>, Via Antonio di Rudinì 8, Milano 20142,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bottinger, Erwin P" sort="Bottinger, Erwin P" uniqKey="Bottinger E" first="Erwin P." last="Bottinger">Erwin P. Bottinger</name><affiliation wicri:level="1"><nlm:aff id="a61"><institution>The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai</institution>, New York, New York 10029,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Murgia, Federico" sort="Murgia, Federico" uniqKey="Murgia F" first="Federico" last="Murgia">Federico Murgia</name><affiliation wicri:level="1"><nlm:aff id="a74"><institution>Institute of Population Genetics—CNR</institution>, Traversa La Crucca 3, 07040 Reg. Baldinca, Li Punti, Sassari,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation wicri:level="1"><nlm:aff id="a39"><institution>Department of Internal Medicine, Erasmus University Medical Center</institution>, PO Box 1738, Rotterdam 3000 DR,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ernst, Florian" sort="Ernst, Florian" uniqKey="Ernst F" first="Florian" last="Ernst">Florian Ernst</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald</institution>, Friedrich-Loeffler-Straße 15a, Greifswald 17487,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kronenberg, Florian" sort="Kronenberg, Florian" uniqKey="Kronenberg F" first="Florian" last="Kronenberg">Florian Kronenberg</name><affiliation wicri:level="1"><nlm:aff id="a45"><institution>Innsbruck Medical University, Division of Genetic Epidemiology</institution>, Schoepfstraße 41, Innsbruck 6020,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hu, Frank B" sort="Hu, Frank B" uniqKey="Hu F" first="Frank B." last="Hu">Frank B. Hu</name><affiliation wicri:level="1"><nlm:aff id="a75"><institution>Department of Nutrition, Harvard School of Public Health</institution>, 665 Huntington Avenue, Building 2, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Navis, Gerjan J" sort="Navis, Gerjan J" uniqKey="Navis G" first="Gerjan J." last="Navis">Gerjan J. Navis</name><affiliation wicri:level="1"><nlm:aff id="a76"><institution>Department of Internal Medicine, University Medical Center Groningen, University of Groningen</institution>, Hanzeplein 1, Groningen 9713 GZ,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Curhan, Gary C" sort="Curhan, Gary C" uniqKey="Curhan G" first="Gary C." last="Curhan">Gary C. Curhan</name><affiliation wicri:level="1"><nlm:aff id="a77"><institution>Brigham and Women's Hospital and Channing Laboratory, Harvard Medical School</institution>, 181 Longwood Avenue, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ehret, George B" sort="Ehret, George B" uniqKey="Ehret G" first="George B." last="Ehret">George B. Ehret</name><affiliation wicri:level="1"><nlm:aff id="a78"><institution>Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospitals</institution>, Rue Gabrielle-Perret-Gentil 4, Geneva 1205,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald</institution>, Friedrich-Loeffler-Straße 15a, Greifswald 17487,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Coassin, Stefan" sort="Coassin, Stefan" uniqKey="Coassin S" first="Stefan" last="Coassin">Stefan Coassin</name><affiliation wicri:level="1"><nlm:aff id="a45"><institution>Innsbruck Medical University, Division of Genetic Epidemiology</institution>, Schoepfstraße 41, Innsbruck 6020,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Thun, Gian Andri" sort="Thun, Gian Andri" uniqKey="Thun G" first="Gian-Andri" last="Thun">Gian-Andri Thun</name><affiliation wicri:level="1"><nlm:aff id="a79"><institution>Swiss Tropical and Public Health Institute</institution>, PO Box 4002, Basel,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a80"><institution>University of Basel</institution>, Petersplatz 1, Basel 4003,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pistis, Giorgio" sort="Pistis, Giorgio" uniqKey="Pistis G" first="Giorgio" last="Pistis">Giorgio Pistis</name><affiliation wicri:level="1"><nlm:aff id="a58"><institution>Division of Genetics and Cell Biology, San Raffaele Scientific Institute</institution>, Via Olgettina 58, Milano 20132,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gambaro, Giovanni" sort="Gambaro, Giovanni" uniqKey="Gambaro G" first="Giovanni" last="Gambaro">Giovanni Gambaro</name><affiliation wicri:level="1"><nlm:aff id="a81"><institution>Division of Nephrology, Department of Internal Medicine and Medical Specialties, Columbus-Gemelli University Hospital, Catholic University</institution>, Via Moscati 31, Rome 00168,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Malerba, Giovanni" sort="Malerba, Giovanni" uniqKey="Malerba G" first="Giovanni" last="Malerba">Giovanni Malerba</name><affiliation wicri:level="1"><nlm:aff id="a8"><institution>Department of Life and Reproduction Sciences, University of Verona</institution>, Strada Le Grazie 8, Verona 37134,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><affiliation wicri:level="1"><nlm:aff id="a82"><institution>Genetic Epidemiology, Queensland Institute of Medical Research, QIMR, PO Royal Brisbane Hospital</institution>, Queensland 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name><affiliation wicri:level="1"><nlm:aff id="a35"><institution>Icelandic Heart Association, Research Institute</institution>, Holtasmari 1, Kopavogur 201,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jacobs, Gunnar" sort="Jacobs, Gunnar" uniqKey="Jacobs G" first="Gunnar" last="Jacobs">Gunnar Jacobs</name><affiliation wicri:level="1"><nlm:aff id="a83"><institution>Institute of Epidemiology and Biobank popgen, Christian-Albrechts University</institution>, Niemannsweg 11, Kiel 24105,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Li, Guo" sort="Li, Guo" uniqKey="Li G" first="Guo" last="Li">Guo Li</name><affiliation wicri:level="1"><nlm:aff id="a64"><institution>Cardiovascular Health Research Unit, Departments of Epidemiology and Medicine, University of Washington</institution>, 1730 Minor Ave, Suite 1360, Seattle, Washington 98101,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H-Erich" last="Wichmann">H-Erich Wichmann</name><affiliation wicri:level="1"><nlm:aff id="a84"><institution>Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health</institution>, Ingolstädter Landstraße 1, Neuherberg 85764,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a85"><institution>Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Ingolstädter Landstrasse 1</institution>, 85764 Neuherberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a86"><institution>Klinikum Grosshadern</institution>, Ingolstädter Landstraße 1, Neuherberg 85764,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation wicri:level="1"><nlm:aff id="a87"><institution>Centre for Population Health Sciences, University of Edinburgh</institution>, Teviot Place, Edinburgh, EH8 9AG Scotland,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><affiliation wicri:level="1"><nlm:aff id="a88"><institution>Austrian Stroke Prevention Study, Institute of Molecular Biology and Biochemistry, Department of Neurology, Medical University Graz</institution>, Harrachgasse 21, Graz 8010,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wallaschofski, Henri" sort="Wallaschofski, Henri" uniqKey="Wallaschofski H" first="Henri" last="Wallaschofski">Henri Wallaschofski</name><affiliation wicri:level="1"><nlm:aff id="a89"><institution>Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald</institution>, Ferdinand-Sauerbruch-Straße, Greifswald 17475,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a90"><institution>German Center for Cardiovascular Research (DZHK)</institution>, Partner site Greifswald, Ferdinand-Sauerbruch-Straße, Greifswald 17475,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Institute for Community Medicine, University of Greifswald</institution>, Walther-Rathenau-Strasse 48, Greifswald 17487,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a90"><institution>German Center for Cardiovascular Research (DZHK)</institution>, Partner site Greifswald, Ferdinand-Sauerbruch-Straße, Greifswald 17475,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="1"><nlm:aff id="a27"><institution>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)</institution>, Im Neuenheimer Feld 581, Heidelberg 69120,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a28"><institution>German Cancer Consortium (DKTK)</institution>, Im Neuenheimer Feld 581, Heidelberg 69120,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kroemer, Heyo K" sort="Kroemer, Heyo K" uniqKey="Kroemer H" first="Heyo K." last="Kroemer">Heyo K. Kroemer</name><affiliation wicri:level="1"><nlm:aff id="a91"><institution>Institute of Pharmacology, University of Greifswald</institution>, Friedrich-Loeffler-Straße 23d, Greifswald 17487,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kramer, Holly" sort="Kramer, Holly" uniqKey="Kramer H" first="Holly" last="Kramer">Holly Kramer</name><affiliation wicri:level="1"><nlm:aff id="a19"><institution>Department of Public Health Sciences, Loyola Medical Center</institution>, 2160 S First Avenue, Maywood, Illinois 60153,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lin, Honghuang" sort="Lin, Honghuang" uniqKey="Lin H" first="Honghuang" last="Lin">Honghuang Lin</name><affiliation wicri:level="1"><nlm:aff id="a92"><institution>Boston University School of Medicine</institution>, 72 East Concord Street, B-616, Boston, Massachusetts 02118,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Leach, I Mateo" sort="Leach, I Mateo" uniqKey="Leach I" first="I. Mateo" last="Leach">I. Mateo Leach</name><affiliation wicri:level="1"><nlm:aff id="a93"><institution>Department of Cardiology, University Medical Center Groningen, University of Groningen</institution>, PO Box 30.001, Groningen 9700 RB,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name><affiliation wicri:level="1"><nlm:aff id="a94"><institution>Robertson Centre for Biostatistics, University of Glasgow</institution>, R1122B Level 11, Robertson Centre, Boyd Orr Building, Glasgow G12 8QQ,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Guessous, Idris" sort="Guessous, Idris" uniqKey="Guessous I" first="Idris" last="Guessous">Idris Guessous</name><affiliation wicri:level="1"><nlm:aff id="a95"><institution>Division of Primary Care Medicine, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals, Faculty of Medicine, University of Geneva</institution>, Geneva 1211,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a96"><institution>Community Prevention Unit, University Institute of Social and Preventive Medicine, Lausanne University Hospital</institution>, Route de la Corniche 10, Lausanne 1010,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a97"><institution>Department of Epidemiology, Rollins School of Public Health, Emory University</institution>, 1518 Clifton Road, NE, Atlanta, Georgia 30322,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation wicri:level="1"><nlm:aff id="a87"><institution>Centre for Population Health Sciences, University of Edinburgh</institution>, Teviot Place, Edinburgh, EH8 9AG Scotland,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation wicri:level="1"><nlm:aff id="a98"><institution>Department of Genomics of Common Disease, School of Public Health, Imperial College London</institution>, London W12 0NN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Borecki, Ingrid" sort="Borecki, Ingrid" uniqKey="Borecki I" first="Ingrid" last="Borecki">Ingrid Borecki</name><affiliation wicri:level="1"><nlm:aff id="a21"><institution>Division of Statistical Genomics, Washington University School of Medicine</institution>, 4444 Forest Park Boulevard, Box 8506, St Louis, Missouri 63108,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Heid, Iris M" sort="Heid, Iris M" uniqKey="Heid I" first="Iris M." last="Heid">Iris M. Heid</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg</institution>, Franz-Josef-Strauß-Allee 11, Regensburg 93053,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a66"><institution>Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health</institution>, Ingolstaedter Landstraße 1, 85764 Neuherberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kolcic, Ivana" sort="Kolcic, Ivana" uniqKey="Kolcic I" first="Ivana" last="Kolcic">Ivana Kolcic</name><affiliation wicri:level="1"><nlm:aff id="a99"><institution>Croatian Centre for Global Health, University of Split Medical School</institution>, Šoltanska 2, Split 21000,<country>Croatia</country></nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Persico, Ivana" sort="Persico, Ivana" uniqKey="Persico I" first="Ivana" last="Persico">Ivana Persico</name><affiliation wicri:level="1"><nlm:aff id="a74"><institution>Institute of Population Genetics—CNR</institution>, Traversa La Crucca 3, 07040 Reg. Baldinca, Li Punti, Sassari,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name><affiliation wicri:level="1"><nlm:aff id="a100"><institution>Department of Cardiology, Leiden University Medical Center</institution>, PO Box 9600, Leiden 2300 RC,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a101"><institution>Interuniversity Cardiology Institute of the Netherlands (ICIN)</institution>, Moreelsepark 1, Utrecht 3511 EP,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a102"><institution>Einthoven Laboratory for Experimental Vascular Medicine</institution>, Albinusdreef 2, Leiden 2333 ZA,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a103"><institution>Durrer Center for Cardiogenetic Research</institution>, Meibergdreef 9, Amsterdam 1105 AZ,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name><affiliation wicri:level="1"><nlm:aff id="a87"><institution>Centre for Population Health Sciences, University of Edinburgh</institution>, Teviot Place, Edinburgh, EH8 9AG Scotland,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Felix, Janine F" sort="Felix, Janine F" uniqKey="Felix J" first="Janine F." last="Felix">Janine F. Felix</name><affiliation wicri:level="1"><nlm:aff id="a24"><institution>Department of Epidemiology, Erasmus University Medical Center</institution>, PO Box 2040, Rotterdam 3000 CA,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Divers, Jasmin" sort="Divers, Jasmin" uniqKey="Divers J" first="Jasmin" last="Divers">Jasmin Divers</name><affiliation wicri:level="1"><nlm:aff id="a104"><institution>Division of Public Health Sciences, Department of Biostatistical Sciences, Wake Forest University Health Sciences</institution>, 2326 Medical Center Boulevard, Winston-Salem, North Carolina 27157-1063,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation wicri:level="1"><nlm:aff id="a105"><institution>INSERM U744, Institut Pasteur de Lille</institution>, 1 rue du Pr, Calmette, Lille Cédex 59019,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stafford, Jeanette M" sort="Stafford, Jeanette M" uniqKey="Stafford J" first="Jeanette M." last="Stafford">Jeanette M. Stafford</name><affiliation wicri:level="1"><nlm:aff id="a104"><institution>Division of Public Health Sciences, Department of Biostatistical Sciences, Wake Forest University Health Sciences</institution>, 2326 Medical Center Boulevard, Winston-Salem, North Carolina 27157-1063,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gaspoz, Jean Michel" sort="Gaspoz, Jean Michel" uniqKey="Gaspoz J" first="Jean-Michel" last="Gaspoz">Jean-Michel Gaspoz</name><affiliation wicri:level="1"><nlm:aff id="a95"><institution>Division of Primary Care Medicine, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals, Faculty of Medicine, University of Geneva</institution>, Geneva 1211,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Smith, Jennifer A" sort="Smith, Jennifer A" uniqKey="Smith J" first="Jennifer A." last="Smith">Jennifer A. Smith</name><affiliation wicri:level="1"><nlm:aff id="a106"><institution>Department of Epidemiology, School of Public Health, University of Michigan</institution>, 1415 Washington Heights, Ann Arbor, Michigan 48109-2029,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Faul, Jessica D" sort="Faul, Jessica D" uniqKey="Faul J" first="Jessica D." last="Faul">Jessica D. Faul</name><affiliation wicri:level="1"><nlm:aff id="a107"><institution>Survey Research Center, Institute for Social Research, University of Michigan</institution>, 426 Thompson Street, #3456, Ann Arbor, Michigan 48104,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name><affiliation wicri:level="1"><nlm:aff id="a108"><institution>Centre for Vision Research, Westmead Millennium Institute, University of Sydney</institution>, C24 Westmead Hospital, New South Wales 2145,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ding, Jingzhong" sort="Ding, Jingzhong" uniqKey="Ding J" first="Jingzhong" last="Ding">Jingzhong Ding</name><affiliation wicri:level="1"><nlm:aff id="a109"><institution>Wake Forest School of Medicine, Department of Internal Medicine/Geriatrics</institution>, Medical center Boulevard, Winston-Salem, North Carolina 27157,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N." last="Hirschhorn">Joel N. Hirschhorn</name><affiliation wicri:level="1"><nlm:aff id="a15"><institution>Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital</institution>, 300 Longwood Avenue, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a16"><institution>Medical and Population Genetics Program, Broad Institute of MIT and Harvard</institution>, Cambridge, Massachusetts 2142,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a110"><institution>Department of Genetics, Harvard Medical School</institution>, 77 Avenue Louis Pasteur, NRB 0330, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Attia, John" sort="Attia, John" uniqKey="Attia J" first="John" last="Attia">John Attia</name><affiliation wicri:level="1"><nlm:aff id="a71"><institution>Division of Biomedical Statistics and Informatics, Mayo Clinic</institution>, 200 First Street SW, Rochester, Minnesota 55905,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a72"><institution>Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, HMRI Building1, Kookaburra Circuit</institution>, New Lambton New South Wales 2305,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John B." last="Whitfield">John B. Whitfield</name><affiliation wicri:level="1"><nlm:aff id="a82"><institution>Genetic Epidemiology, Queensland Institute of Medical Research, QIMR, PO Royal Brisbane Hospital</institution>, Queensland 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name><affiliation wicri:level="1"><nlm:aff id="a111"><institution>University of Sydney, The George Institute for Global Health</institution>, Level 10, King George V Building, 83-117 Missenden Road, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Viikari, Jorma" sort="Viikari, Jorma" uniqKey="Viikari J" first="Jorma" last="Viikari">Jorma Viikari</name><affiliation wicri:level="1"><nlm:aff id="a112"><institution>Department of Medicine, University of Turku, Turku University Hospital</institution>, PO Box 52, Turku 20521,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Coresh, Josef" sort="Coresh, Josef" uniqKey="Coresh J" first="Josef" last="Coresh">Josef Coresh</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health</institution>, 615 North Wolfe Street, Baltimore, Maryland 21205,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a113"><institution>Welch Center for Prevention, Epidemiology and Clinical Research</institution>, 2024 East Monument St, Suite 2-600, Baltimore, Maryland 21287,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Denny, Joshua C" sort="Denny, Joshua C" uniqKey="Denny J" first="Joshua C." last="Denny">Joshua C. Denny</name><affiliation wicri:level="1"><nlm:aff id="a114"><institution>Vanderbilt University School of Medicine</institution>, 448 Eskind Biomedical Library, 2209 Garland Avenue, Nashville, Tennessee 37212,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Karjalainen, Juha" sort="Karjalainen, Juha" uniqKey="Karjalainen J" first="Juha" last="Karjalainen">Juha Karjalainen</name><affiliation wicri:level="1"><nlm:aff id="a115"><institution>Department of Genetics, University of Groningen, University Medical Centre Groningen</institution>, PO Box 72, Groningen 9700 AB,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fernandes, Jyotika K" sort="Fernandes, Jyotika K" uniqKey="Fernandes J" first="Jyotika K." last="Fernandes">Jyotika K. Fernandes</name><affiliation wicri:level="1"><nlm:aff id="a116"><institution>Division of Endocrinology, Medical University of South Carolina</institution>, 171 Ashley Avenue, Charleston, South Carolina 29425,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Endlich, Karlhans" sort="Endlich, Karlhans" uniqKey="Endlich K" first="Karlhans" last="Endlich">Karlhans Endlich</name><affiliation wicri:level="1"><nlm:aff id="a117"><institution>Institute of Anatomy and Cell Biology, University of Greifswald</institution>, Friedrich-Loeffler-Straße 23c, Greifswald 17487,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Butterbach, Katja" sort="Butterbach, Katja" uniqKey="Butterbach K" first="Katja" last="Butterbach">Katja Butterbach</name><affiliation wicri:level="1"><nlm:aff id="a27"><institution>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)</institution>, Im Neuenheimer Feld 581, Heidelberg 69120,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Keene, Keith L" sort="Keene, Keith L" uniqKey="Keene K" first="Keith L." last="Keene">Keith L. Keene</name><affiliation wicri:level="1"><nlm:aff id="a118"><institution>Center for Health Disparities, Department of Biology, East Carolina University</institution>, 1001 East 10th Street, N209 Howell Science Complex Mailstop 551, Greenville, North Carolina 27858,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lohman, Kurt" sort="Lohman, Kurt" uniqKey="Lohman K" first="Kurt" last="Lohman">Kurt Lohman</name><affiliation wicri:level="1"><nlm:aff id="a46"><institution>Internal Medicine Department, Wake Forest School of Medicine</institution>, Medical Center Boulevard, Winston-Salem, North Carolina 27157-1053,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Portas, Laura" sort="Portas, Laura" uniqKey="Portas L" first="Laura" last="Portas">Laura Portas</name><affiliation wicri:level="1"><nlm:aff id="a74"><institution>Institute of Population Genetics—CNR</institution>, Traversa La Crucca 3, 07040 Reg. Baldinca, Li Punti, Sassari,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name><affiliation wicri:level="1"><nlm:aff id="a119"><institution>Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Gateway Building</institution>, 3C309, 7201 Winsconsin Avenue, Bethesda, Maryland 20892-9205,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lyytik Inen, Leo Pekka" sort="Lyytik Inen, Leo Pekka" uniqKey="Lyytik Inen L" first="Leo-Pekka" last="Lyytik Inen">Leo-Pekka Lyytik Inen</name><affiliation wicri:level="1"><nlm:aff id="a120"><institution>Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere, School of Medicine</institution>, Tampere 33520,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yengo, Loic" sort="Yengo, Loic" uniqKey="Yengo L" first="Loic" last="Yengo">Loic Yengo</name><affiliation wicri:level="1"><nlm:aff id="a121"><institution>CNRS UMR 8199</institution>, 1 Rue du Professeur Calmette, Lille 59000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a122"><institution>Lille Pasteur Institute</institution>, 1 Rue du Professeur Calmette, Lille 59000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a123"><institution>Lille II University</institution>, 42 Rue paul Duez, Lille 59000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Franke, Lude" sort="Franke, Lude" uniqKey="Franke L" first="Lude" last="Franke">Lude Franke</name><affiliation wicri:level="1"><nlm:aff id="a115"><institution>Department of Genetics, University of Groningen, University Medical Centre Groningen</institution>, PO Box 72, Groningen 9700 AB,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation wicri:level="1"><nlm:aff id="a124"><institution>Clinical Research Branch, National Institute on Aging</institution>, 251 Bayview Blvd, Baltimore, Maryland 21250,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rose, Lynda M" sort="Rose, Lynda M" uniqKey="Rose L" first="Lynda M." last="Rose">Lynda M. Rose</name><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Preventive Medicine, Brigham and Women's Hospital</institution>, 900 Commonwealth Avenue East, Boston, Massachusetts 02215,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kedenko, Lyudmyla" sort="Kedenko, Lyudmyla" uniqKey="Kedenko L" first="Lyudmyla" last="Kedenko">Lyudmyla Kedenko</name><affiliation wicri:level="1"><nlm:aff id="a49"><institution>First Department of Internal Medicine, Paracelsus Medical University/Salzburger Landeskliniken</institution>, Müllner Hauptstraße 48, Salzburg 5020,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rao, Madhumathi" sort="Rao, Madhumathi" uniqKey="Rao M" first="Madhumathi" last="Rao">Madhumathi Rao</name><affiliation wicri:level="1"><nlm:aff id="a12"><institution>Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Tufts Medical Center</institution>, Boston, Massachusetts 02111,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Struchalin, Maksim" sort="Struchalin, Maksim" uniqKey="Struchalin M" first="Maksim" last="Struchalin">Maksim Struchalin</name><affiliation wicri:level="1"><nlm:aff id="a125"><institution>Department of Epidemiology and Biostatistics, Erasmus University Medical Center</institution>, Dr Molewaterplein, Rotterdam 50-603015 GE,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a126"><institution>Department of Forensic Molecular Biology, Erasmus University Medical Center</institution>, Dr Molewaterplein, Rotterdam 50-603015 GE,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kleber, Marcus E" sort="Kleber, Marcus E" uniqKey="Kleber M" first="Marcus E." last="Kleber">Marcus E. Kleber</name><affiliation wicri:level="1"><nlm:aff id="a127"><institution>Medical Clinic V, Medical Faculty Mannheim, Heidelberg University</institution>, Theodor-Kutzer-Ufer 1-3, Mannheim 68167,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cavalieri, Margherita" sort="Cavalieri, Margherita" uniqKey="Cavalieri M" first="Margherita" last="Cavalieri">Margherita Cavalieri</name><affiliation wicri:level="1"><nlm:aff id="a128"><institution>Austrian Stroke Prevention Study, Department of Neurology, Division of Special Neurology, Medical University Graz</institution>, Auenbruggerplatz 22, Graz 8036,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Haun, Margot" sort="Haun, Margot" uniqKey="Haun M" first="Margot" last="Haun">Margot Haun</name><affiliation wicri:level="1"><nlm:aff id="a45"><institution>Innsbruck Medical University, Division of Genetic Epidemiology</institution>, Schoepfstraße 41, Innsbruck 6020,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cornelis, Marilyn C" sort="Cornelis, Marilyn C" uniqKey="Cornelis M" first="Marilyn C." last="Cornelis">Marilyn C. Cornelis</name><affiliation wicri:level="1"><nlm:aff id="a75"><institution>Department of Nutrition, Harvard School of Public Health</institution>, 665 Huntington Avenue, Building 2, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ciullo, Marina" sort="Ciullo, Marina" uniqKey="Ciullo M" first="Marina" last="Ciullo">Marina Ciullo</name><affiliation wicri:level="1"><nlm:aff id="a10"><institution>Institute of Genetics and Biophysics "Adriano Buzzati-Traverso"—CNR</institution>, Via P. Castellino 111, Napoli 80131,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pirastu, Mario" sort="Pirastu, Mario" uniqKey="Pirastu M" first="Mario" last="Pirastu">Mario Pirastu</name><affiliation wicri:level="1"><nlm:aff id="a74"><institution>Institute of Population Genetics—CNR</institution>, Traversa La Crucca 3, 07040 Reg. Baldinca, Li Punti, Sassari,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De Andrade, Mariza" sort="De Andrade, Mariza" uniqKey="De Andrade M" first="Mariza" last="De Andrade">Mariza De Andrade</name><affiliation wicri:level="1"><nlm:aff id="a71"><institution>Division of Biomedical Statistics and Informatics, Mayo Clinic</institution>, 200 First Street SW, Rochester, Minnesota 55905,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mcevoy, Mark A" sort="Mcevoy, Mark A" uniqKey="Mcevoy M" first="Mark A." last="Mcevoy">Mark A. Mcevoy</name><affiliation wicri:level="1"><nlm:aff id="a129"><institution>Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Hunter Medical Research Institute, John Hunter Hospital</institution>, Locked Bag 1, HRMC, New South Wales 2310,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health</institution>, 615 North Wolfe Street, Baltimore, Maryland 21205,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a111"><institution>University of Sydney, The George Institute for Global Health</institution>, Level 10, King George V Building, 83-117 Missenden Road, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a112"><institution>Department of Medicine, University of Turku, Turku University Hospital</institution>, PO Box 52, Turku 20521,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a130"><institution>The George Institute for Global Health, Nuffield Department of Population Health, University of Oxford</institution>, Old Road Campus, Roosevelt Drive, Oxford OX3 7LF,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Adam, Martin" sort="Adam, Martin" uniqKey="Adam M" first="Martin" last="Adam">Martin Adam</name><affiliation wicri:level="1"><nlm:aff id="a79"><institution>Swiss Tropical and Public Health Institute</institution>, PO Box 4002, Basel,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a80"><institution>University of Basel</institution>, Petersplatz 1, Basel 4003,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cocca, Massimiliano" sort="Cocca, Massimiliano" uniqKey="Cocca M" first="Massimiliano" last="Cocca">Massimiliano Cocca</name><affiliation wicri:level="1"><nlm:aff id="a58"><institution>Division of Genetics and Cell Biology, San Raffaele Scientific Institute</institution>, Via Olgettina 58, Milano 20132,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nauck, Matthias" sort="Nauck, Matthias" uniqKey="Nauck M" first="Matthias" last="Nauck">Matthias Nauck</name><affiliation wicri:level="1"><nlm:aff id="a89"><institution>Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald</institution>, Ferdinand-Sauerbruch-Straße, Greifswald 17475,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a90"><institution>German Center for Cardiovascular Research (DZHK)</institution>, Partner site Greifswald, Ferdinand-Sauerbruch-Straße, Greifswald 17475,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Imboden, Medea" sort="Imboden, Medea" uniqKey="Imboden M" first="Medea" last="Imboden">Medea Imboden</name><affiliation wicri:level="1"><nlm:aff id="a79"><institution>Swiss Tropical and Public Health Institute</institution>, PO Box 4002, Basel,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a80"><institution>University of Basel</institution>, Petersplatz 1, Basel 4003,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Waldenberger, Melanie" sort="Waldenberger, Melanie" uniqKey="Waldenberger M" first="Melanie" last="Waldenberger">Melanie Waldenberger</name><affiliation wicri:level="1"><nlm:aff id="a67"><institution>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health</institution>, Ingolstaedter Landstraße 1, 85764 Neuherberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pruijm, Menno" sort="Pruijm, Menno" uniqKey="Pruijm M" first="Menno" last="Pruijm">Menno Pruijm</name><affiliation wicri:level="1"><nlm:aff id="a131"><institution>Service of Nephrology, Lausanne University Hospital</institution>, Rue du Bugnon 17, Lausanne 1005,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Metzger, Marie" sort="Metzger, Marie" uniqKey="Metzger M" first="Marie" last="Metzger">Marie Metzger</name><affiliation wicri:level="1"><nlm:aff id="a132"><institution>Inserm UMRS 1018, CESP Team 10, Université Paris-Sud</institution>, 16 avenue Paul Vaillant Couturier, Villejuif 94807,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stumvoll, Michael" sort="Stumvoll, Michael" uniqKey="Stumvoll M" first="Michael" last="Stumvoll">Michael Stumvoll</name><affiliation wicri:level="1"><nlm:aff id="a42"><institution>Department of Medicine, University of Leipzig</institution>, Liebigstraße 18, Leipzig 04103,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Evans, Michele K" sort="Evans, Michele K" uniqKey="Evans M" first="Michele K." last="Evans">Michele K. Evans</name><affiliation wicri:level="1"><nlm:aff id="a133"><institution>Health Disparities Research Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, NIH Biomedical Center</institution>, 251 Bayview Boulevard, Suite 100, Baltimore, Maryland 21224,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sale, Michele M" sort="Sale, Michele M" uniqKey="Sale M" first="Michele M." last="Sale">Michele M. Sale</name><affiliation wicri:level="1"><nlm:aff id="a134"><institution>Center for Public Health Genomics, Department of Medicine (Cardiovascular Medicine), University of Virginia</institution>, PO Box 800717, Charlottesville, Virginia 22908,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation wicri:level="1"><nlm:aff id="a135"><institution>Department of Clinical Physiology, Tampere University Hospital, University of Tampere, School of Medicine</institution>, Tampere 33521,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boban, Mladen" sort="Boban, Mladen" uniqKey="Boban M" first="Mladen" last="Boban">Mladen Boban</name><affiliation wicri:level="1"><nlm:aff id="a99"><institution>Croatian Centre for Global Health, University of Split Medical School</institution>, Šoltanska 2, Split 21000,<country>Croatia</country></nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bochud, Murielle" sort="Bochud, Murielle" uniqKey="Bochud M" first="Murielle" last="Bochud">Murielle Bochud</name><affiliation wicri:level="1"><nlm:aff id="a136"><institution>University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne</institution>, Route de la Corniche 2, Epalinges CH-1066,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rheinberger, Myriam" sort="Rheinberger, Myriam" uniqKey="Rheinberger M" first="Myriam" last="Rheinberger">Myriam Rheinberger</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Department of Nephrology, University Hospital Regensburg</institution>, Franz-Josef-Strauß-Allee 11, Regensburg 93053,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Verweij, Niek" sort="Verweij, Niek" uniqKey="Verweij N" first="Niek" last="Verweij">Niek Verweij</name><affiliation wicri:level="1"><nlm:aff id="a93"><institution>Department of Cardiology, University Medical Center Groningen, University of Groningen</institution>, PO Box 30.001, Groningen 9700 RB,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bouatia Naji, Nabila" sort="Bouatia Naji, Nabila" uniqKey="Bouatia Naji N" first="Nabila" last="Bouatia-Naji">Nabila Bouatia-Naji</name><affiliation wicri:level="1"><nlm:aff id="a137"><institution>INSERM UMR970, Paris Cardiovascular Research Center (PARCC)</institution>, 56 rue Leblanc, Paris F-75015,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a138"><institution>Paris Descartes University, Faculty of medicine, Paris Cité Sorbonne</institution>, 12 Rue de l'école de Médecine, Paris F-75006,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation wicri:level="1"><nlm:aff id="a82"><institution>Genetic Epidemiology, Queensland Institute of Medical Research, QIMR, PO Royal Brisbane Hospital</institution>, Queensland 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a139"><institution>Brigham and Women's Hospital, Harvard Medical School</institution>, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hastie, Nick" sort="Hastie, Nick" uniqKey="Hastie N" first="Nick" last="Hastie">Nick Hastie</name><affiliation wicri:level="1"><nlm:aff id="a31"><institution>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>, Crewe Road, Edinburgh EH4 2XU,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Probst Hensch, Nicole" sort="Probst Hensch, Nicole" uniqKey="Probst Hensch N" first="Nicole" last="Probst-Hensch">Nicole Probst-Hensch</name><affiliation wicri:level="1"><nlm:aff id="a79"><institution>Swiss Tropical and Public Health Institute</institution>, PO Box 4002, Basel,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a80"><institution>University of Basel</institution>, Petersplatz 1, Basel 4003,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation wicri:level="1"><nlm:aff id="a140"><institution>Wellcome Trust Sanger Institute</institution>, Hinxton CB10 1HH,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Devuyst, Olivier" sort="Devuyst, Olivier" uniqKey="Devuyst O" first="Olivier" last="Devuyst">Olivier Devuyst</name><affiliation wicri:level="1"><nlm:aff id="a141"><institution>University of Zurich, Institute of Physiology, Mechanisms of Inherited Kidney Disorders Group</institution>, Winterthurerstrasse 190, Zürich 8057,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><affiliation wicri:level="1"><nlm:aff id="a142"><institution>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku University Hospital, Department of Clinical Physiology</institution>, PO Box 52, Turku 20521,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gottesman, Omri" sort="Gottesman, Omri" uniqKey="Gottesman O" first="Omri" last="Gottesman">Omri Gottesman</name><affiliation wicri:level="1"><nlm:aff id="a61"><institution>The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai</institution>, New York, New York 10029,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H." last="Franco">Oscar H. Franco</name><affiliation wicri:level="1"><nlm:aff id="a24"><institution>Department of Epidemiology, Erasmus University Medical Center</institution>, PO Box 2040, Rotterdam 3000 CA,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name><affiliation wicri:level="1"><nlm:aff id="a99"><institution>Croatian Centre for Global Health, University of Split Medical School</institution>, Šoltanska 2, Split 21000,<country>Croatia</country></nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gasparini, Paolo" sort="Gasparini, Paolo" uniqKey="Gasparini P" first="Paolo" last="Gasparini">Paolo Gasparini</name><affiliation wicri:level="1"><nlm:aff id="a25"><institution>Institute for Maternal and Child Health—IRCCS "Burlo Garofolo" and University of Trieste</institution>, via dell'Istria 65/1, Trieste 34137,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Munroe, Patricia B" sort="Munroe, Patricia B" uniqKey="Munroe P" first="Patricia B." last="Munroe">Patricia B. Munroe</name><affiliation wicri:level="1"><nlm:aff id="a143"><institution>Department Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London</institution>, London EC1M 6BQ,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a144"><institution>NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London</institution>, London EC1M 6BQ,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M." last="Ridker">Paul M. Ridker</name><affiliation wicri:level="1"><nlm:aff id="a145"><institution>Harvard Medical School</institution>, 900 Commonwealth Avenue East, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name><affiliation wicri:level="1"><nlm:aff id="a108"><institution>Centre for Vision Research, Westmead Millennium Institute, University of Sydney</institution>, C24 Westmead Hospital, New South Wales 2145,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Muntner, Paul" sort="Muntner, Paul" uniqKey="Muntner P" first="Paul" last="Muntner">Paul Muntner</name><affiliation wicri:level="1"><nlm:aff id="a146"><institution>University of Alabama at Birmingham, Department of Medicine</institution>, 1530 3rd Avenue, South Birmingham, Alabama 35294-0022,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a147"><institution>University of Alabama at Birmingham, Department of Epidemiology</institution>, 1530 3rd Avenue, South Birmingham, Alabama 35294-0022,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Meisinger, Christa" sort="Meisinger, Christa" uniqKey="Meisinger C" first="Christa" last="Meisinger">Christa Meisinger</name><affiliation wicri:level="1"><nlm:aff id="a68"><institution>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health</institution>, 85764 Neuherberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Smit, Johannes H" sort="Smit, Johannes H" uniqKey="Smit J" first="Johannes H." last="Smit">Johannes H. Smit</name><affiliation wicri:level="1"><nlm:aff id="a148"><institution>Department of Psychiatry and EMGO+ Institute, VU University Medical Center</institution>, A.J. Ernststraat 1187, Amsterdam 1081 HL,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kovacs, Peter" sort="Kovacs, Peter" uniqKey="Kovacs P" first="Peter" last="Kovacs">Peter Kovacs</name><affiliation wicri:level="1"><nlm:aff id="a149"><institution>IFB AdiposityDiseases, University of Leipzig</institution>, Liebigstraße 21, Leipzig 04103,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wild, Philipp S" sort="Wild, Philipp S" uniqKey="Wild P" first="Philipp S." last="Wild">Philipp S. Wild</name><affiliation wicri:level="1"><nlm:aff id="a150"><institution>Medical University Center Mainz</institution>, Langenbeckstraße 1, Mainz 55131,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation wicri:level="1"><nlm:aff id="a121"><institution>CNRS UMR 8199</institution>, 1 Rue du Professeur Calmette, Lille 59000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a122"><institution>Lille Pasteur Institute</institution>, 1 Rue du Professeur Calmette, Lille 59000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a123"><institution>Lille II University</institution>, 42 Rue paul Duez, Lille 59000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rettig, Rainer" sort="Rettig, Rainer" uniqKey="Rettig R" first="Rainer" last="Rettig">Rainer Rettig</name><affiliation wicri:level="1"><nlm:aff id="a151"><institution>Institute of Physiology, University of Greifswald</institution>, Greifswald 17487,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name><affiliation wicri:level="1"><nlm:aff id="a40"><institution>Estonian Genome Center of University of Tartu (EGCUT)</institution>, Riia 23B, Tartu 51010,<country>Estonia</country></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Biffar, Reiner" sort="Biffar, Reiner" uniqKey="Biffar R" first="Reiner" last="Biffar">Reiner Biffar</name><affiliation wicri:level="1"><nlm:aff id="a152"><institution>Clinic for Prosthodontic Dentistry, Gerostomatology and Material Science, University of Greifswald</institution>, Rotgerberstraße 8, Greifswald 17475,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation wicri:level="1"><nlm:aff id="a128"><institution>Austrian Stroke Prevention Study, Department of Neurology, Division of Special Neurology, Medical University Graz</institution>, Auenbruggerplatz 22, Graz 8036,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Middelberg, Rita P S" sort="Middelberg, Rita P S" uniqKey="Middelberg R" first="Rita P. S." last="Middelberg">Rita P. S. Middelberg</name><affiliation wicri:level="1"><nlm:aff id="a82"><institution>Genetic Epidemiology, Queensland Institute of Medical Research, QIMR, PO Royal Brisbane Hospital</institution>, Queensland 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Carroll, Robert J" sort="Carroll, Robert J" uniqKey="Carroll R" first="Robert J." last="Carroll">Robert J. Carroll</name><affiliation wicri:level="1"><nlm:aff id="a114"><institution>Vanderbilt University School of Medicine</institution>, 448 Eskind Biomedical Library, 2209 Garland Avenue, Nashville, Tennessee 37212,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Penninx, Brenda W" sort="Penninx, Brenda W" uniqKey="Penninx B" first="Brenda W." last="Penninx">Brenda W. Penninx</name><affiliation wicri:level="1"><nlm:aff id="a148"><institution>Department of Psychiatry and EMGO+ Institute, VU University Medical Center</institution>, A.J. Ernststraat 1187, Amsterdam 1081 HL,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J." last="Scott">Rodney J. Scott</name><affiliation wicri:level="1"><nlm:aff id="a153"><institution>School of Biomedical Sciences and Pharmacy, University of Newcastle, Hunter Medical Research Institute, John Hunter Hospital</institution>, Locked Bag 1, HRMC, New South Wales 2310,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Katz, Ronit" sort="Katz, Ronit" uniqKey="Katz R" first="Ronit" last="Katz">Ronit Katz</name><affiliation wicri:level="1"><nlm:aff id="a154"><institution>Kidney Research Institute, University of Washington</institution>, Box 359606, 325 9th Avenue, Seattle, Washington 98104,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sedaghat, Sanaz" sort="Sedaghat, Sanaz" uniqKey="Sedaghat S" first="Sanaz" last="Sedaghat">Sanaz Sedaghat</name><affiliation wicri:level="1"><nlm:aff id="a24"><institution>Department of Epidemiology, Erasmus University Medical Center</institution>, PO Box 2040, Rotterdam 3000 CA,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H." last="Wild">Sarah H. Wild</name><affiliation wicri:level="1"><nlm:aff id="a87"><institution>Centre for Population Health Sciences, University of Edinburgh</institution>, Teviot Place, Edinburgh, EH8 9AG Scotland,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kardia, Sharon L R" sort="Kardia, Sharon L R" uniqKey="Kardia S" first="Sharon L. R." last="Kardia">Sharon L. R. Kardia</name><affiliation wicri:level="1"><nlm:aff id="a106"><institution>Department of Epidemiology, School of Public Health, University of Michigan</institution>, 1415 Washington Heights, Ann Arbor, Michigan 48109-2029,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ulivi, Sheila" sort="Ulivi, Sheila" uniqKey="Ulivi S" first="Sheila" last="Ulivi">Sheila Ulivi</name><affiliation wicri:level="1"><nlm:aff id="a155"><institution>Institute for Maternal and Child Health—IRCCS "Burlo Garofolo"</institution>, Via dell'Istria 65, Trieste 34137,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hwang, Shih Jen" sort="Hwang, Shih Jen" uniqKey="Hwang S" first="Shih-Jen" last="Hwang">Shih-Jen Hwang</name><affiliation wicri:level="1"><nlm:aff id="a17"><institution>NHLBI's Framingham Heart Study and the Center for Population Studies</institution>, 73 Mt Wayte Avenue, Suite 2, Framingham, Massachusetts 01702,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Enroth, Stefan" sort="Enroth, Stefan" uniqKey="Enroth S" first="Stefan" last="Enroth">Stefan Enroth</name><affiliation wicri:level="1"><nlm:aff id="a44"><institution>Uppsala University, Department of Immunology, Genetics and Pathology, Biomedical Center, SciLifeLab, Uppsala University</institution>, Uppsala SE- 75108,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kloiber, Stefan" sort="Kloiber, Stefan" uniqKey="Kloiber S" first="Stefan" last="Kloiber">Stefan Kloiber</name><affiliation wicri:level="1"><nlm:aff id="a63"><institution>Max Planck Institute of Psychiatry</institution>, Kraepelinstraße 2–10, Munich 80804,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name><affiliation wicri:level="1"><nlm:aff id="a100"><institution>Department of Cardiology, Leiden University Medical Center</institution>, PO Box 9600, Leiden 2300 RC,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stengel, Benedicte" sort="Stengel, Benedicte" uniqKey="Stengel B" first="Benedicte" last="Stengel">Benedicte Stengel</name><affiliation wicri:level="1"><nlm:aff id="a132"><institution>Inserm UMRS 1018, CESP Team 10, Université Paris-Sud</institution>, 16 avenue Paul Vaillant Couturier, Villejuif 94807,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hancock, Stephen J" sort="Hancock, Stephen J" uniqKey="Hancock S" first="Stephen J." last="Hancock">Stephen J. Hancock</name><affiliation wicri:level="1"><nlm:aff id="a72"><institution>Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, HMRI Building1, Kookaburra Circuit</institution>, New Lambton New South Wales 2305,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a73"><institution>Clinical Research Design, Information Technology and Statistical Support, Hunter Medical Research Institute, Newcastle</institution>, 1 Kookaburra Circuit, New Lambton Heights, New South Wales 2305,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Turner, Stephen T" sort="Turner, Stephen T" uniqKey="Turner S" first="Stephen T." last="Turner">Stephen T. Turner</name><affiliation wicri:level="1"><nlm:aff id="a156"><institution>Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic</institution>, 200 First Street SW, Rochester, Minnesota 55905,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rosas, Sylvia E" sort="Rosas, Sylvia E" uniqKey="Rosas S" first="Sylvia E." last="Rosas">Sylvia E. Rosas</name><affiliation wicri:level="1"><nlm:aff id="a18"><institution>Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania</institution>, 415 Curie Boulevard, 405B Clinical Research Building, Philadelphia, Pennsylvania 19104-4539,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stracke, Sylvia" sort="Stracke, Sylvia" uniqKey="Stracke S" first="Sylvia" last="Stracke">Sylvia Stracke</name><affiliation wicri:level="1"><nlm:aff id="a105"><institution>INSERM U744, Institut Pasteur de Lille</institution>, 1 rue du Pr, Calmette, Lille Cédex 59019,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a157"><institution>Clinic for Internal Medicine A, University of Greifswald</institution>, Friedrich-Loeffler-Straße 23a, Greifswald 17475,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation wicri:level="1"><nlm:aff id="a119"><institution>Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Gateway Building</institution>, 3C309, 7201 Winsconsin Avenue, Bethesda, Maryland 20892-9205,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zeller, Tanja" sort="Zeller, Tanja" uniqKey="Zeller T" first="Tanja" last="Zeller">Tanja Zeller</name><affiliation wicri:level="1"><nlm:aff id="a56"><institution>University Heart Center Hamburg, Clinic for general and interventional cardiology</institution>, Martinistraße 52, Hamburg 20246,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a57"><institution>German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Lübeck/Kiel</institution>, Martinistraße 52, Hamburg 20246, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>, Martinistraße 52, Hamburg 20246</wicri:regionArea><wicri:noRegion>20246</wicri:noRegion><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Zemunik, Tatijana" sort="Zemunik, Tatijana" uniqKey="Zemunik T" first="Tatijana" last="Zemunik">Tatijana Zemunik</name><affiliation wicri:level="1"><nlm:aff id="a99"><institution>Croatian Centre for Global Health, University of Split Medical School</institution>, Šoltanska 2, Split 21000,<country>Croatia</country></nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation wicri:level="1"><nlm:aff id="a120"><institution>Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere, School of Medicine</institution>, Tampere 33520,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name><affiliation wicri:level="1"><nlm:aff id="a68"><institution>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health</institution>, 85764 Neuherberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Aspelund, Thor" sort="Aspelund, Thor" uniqKey="Aspelund T" first="Thor" last="Aspelund">Thor Aspelund</name><affiliation wicri:level="1"><nlm:aff id="a35"><institution>Icelandic Heart Association, Research Institute</institution>, Holtasmari 1, Kopavogur 201,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a36"><institution>University of Iceland</institution>, Sæmundargötu 2, Reykjavik 101,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nikopensius, Tiit" sort="Nikopensius, Tiit" uniqKey="Nikopensius T" first="Tiit" last="Nikopensius">Tiit Nikopensius</name><affiliation wicri:level="1"><nlm:aff id="a40"><institution>Estonian Genome Center of University of Tartu (EGCUT)</institution>, Riia 23B, Tartu 51010,<country>Estonia</country></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a41"><institution>Institute of Molecular and Cell Biology, University of Tartu and Estonian Biocenter</institution>, Riia 23, Tartu 51010,<country>Estonia</country></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Esko, Tonu" sort="Esko, Tonu" uniqKey="Esko T" first="Tonu" last="Esko">Tonu Esko</name><affiliation wicri:level="1"><nlm:aff id="a15"><institution>Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital</institution>, 300 Longwood Avenue, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a40"><institution>Estonian Genome Center of University of Tartu (EGCUT)</institution>, Riia 23B, Tartu 51010,<country>Estonia</country></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a41"><institution>Institute of Molecular and Cell Biology, University of Tartu and Estonian Biocenter</institution>, Riia 23, Tartu 51010,<country>Estonia</country></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name><affiliation wicri:level="1"><nlm:aff id="a124"><institution>Clinical Research Branch, National Institute on Aging</institution>, 251 Bayview Blvd, Baltimore, Maryland 21250,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><affiliation wicri:level="1"><nlm:aff id="a44"><institution>Uppsala University, Department of Immunology, Genetics and Pathology, Biomedical Center, SciLifeLab, Uppsala University</institution>, Uppsala SE- 75108,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald</institution>, Friedrich-Loeffler-Straße 15a, Greifswald 17487,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a90"><institution>German Center for Cardiovascular Research (DZHK)</institution>, Partner site Greifswald, Ferdinand-Sauerbruch-Straße, Greifswald 17475,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Emilsson, Valur" sort="Emilsson, Valur" uniqKey="Emilsson V" first="Valur" last="Emilsson">Valur Emilsson</name><affiliation wicri:level="1"><nlm:aff id="a35"><institution>Icelandic Heart Association, Research Institute</institution>, Holtasmari 1, Kopavogur 201,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a158"><institution>Faculty of Pharmaceutical Sciences, University of Iceland</institution>, Sæmundargata 2, Reykjavik 101,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><affiliation wicri:level="1"><nlm:aff id="a31"><institution>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>, Crewe Road, Edinburgh EH4 2XU,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Aalto, Ville" sort="Aalto, Ville" uniqKey="Aalto V" first="Ville" last="Aalto">Ville Aalto</name><affiliation wicri:level="1"><nlm:aff id="a159"><institution>Department of Clinical Physiology, Turku University Hospital, Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku</institution>, PO Box 52, Turku 20521,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation wicri:level="1"><nlm:aff id="a35"><institution>Icelandic Heart Association, Research Institute</institution>, Holtasmari 1, Kopavogur 201,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a36"><institution>University of Iceland</institution>, Sæmundargötu 2, Reykjavik 101,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chouraki, Vincent" sort="Chouraki, Vincent" uniqKey="Chouraki V" first="Vincent" last="Chouraki">Vincent Chouraki</name><affiliation wicri:level="1"><nlm:aff id="a105"><institution>INSERM U744, Institut Pasteur de Lille</institution>, 1 rue du Pr, Calmette, Lille Cédex 59019,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Wei Min" sort="Chen, Wei Min" uniqKey="Chen W" first="Wei-Min" last="Chen">Wei-Min Chen</name><affiliation wicri:level="1"><nlm:aff id="a134"><institution>Center for Public Health Genomics, Department of Medicine (Cardiovascular Medicine), University of Virginia</institution>, PO Box 800717, Charlottesville, Virginia 22908,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Igl, Wilmar" sort="Igl, Wilmar" uniqKey="Igl W" first="Wilmar" last="Igl">Wilmar Igl</name><affiliation wicri:level="1"><nlm:aff id="a44"><institution>Uppsala University, Department of Immunology, Genetics and Pathology, Biomedical Center, SciLifeLab, Uppsala University</institution>, Uppsala SE- 75108,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="M Rz, Winfried" sort="M Rz, Winfried" uniqKey="M Rz W" first="Winfried" last="M Rz">Winfried M Rz</name><affiliation wicri:level="1"><nlm:aff id="a160"><institution>Synlab Academy, Synlab Services GmbH</institution>, Oberer Eselsberg 45, Ulm 89081,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name><affiliation wicri:level="1"><nlm:aff id="a161"><institution>Department of Internal Medicine II—Cardiology, University of Ulm Medical Centre</institution>, Albert-Einstein-Allee 23, Ulm 89081,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lieb, Wolfgang" sort="Lieb, Wolfgang" uniqKey="Lieb W" first="Wolfgang" last="Lieb">Wolfgang Lieb</name><affiliation wicri:level="1"><nlm:aff id="a83"><institution>Institute of Epidemiology and Biobank popgen, Christian-Albrechts University</institution>, Niemannsweg 11, Kiel 24105,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J. F." last="Loos">Ruth J. F. Loos</name><affiliation wicri:level="1"><nlm:aff id="a61"><institution>The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai</institution>, New York, New York 10029,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a162"><institution>The Mindich Child Health and Development Institute, Ichan School of Medicine at Mount Sinai</institution>, New York, New York 10029,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name><affiliation wicri:level="1"><nlm:aff id="a46"><institution>Internal Medicine Department, Wake Forest School of Medicine</institution>, Medical Center Boulevard, Winston-Salem, North Carolina 27157-1053,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Snieder, Harold" sort="Snieder, Harold" uniqKey="Snieder H" first="Harold" last="Snieder">Harold Snieder</name><affiliation wicri:level="1"><nlm:aff id="a30"><institution>Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen</institution>, PO Box 30001, Groningen 9700 RB,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck</institution>, Via Galvani 31, Bolzano 39100,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a163"><institution>Department of Neurology, General Central Hospital</institution>, Via Lorenz Bohler 5, Bolzano 39100,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a164"><institution>Department of Neurology, University of Lübeck</institution>, Ratzeburger Allee 160, Lübeck 23538,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Parsa, Afshin" sort="Parsa, Afshin" uniqKey="Parsa A" first="Afshin" last="Parsa">Afshin Parsa</name><affiliation wicri:level="1"><nlm:aff id="a165"><institution>University of Maryland Medical School, Division of Nephrology</institution>, 685 W. Baltimore Street, MSTF 314, Baltimore, Maryland 21201,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="O Connell, Jeffrey R" sort="O Connell, Jeffrey R" uniqKey="O Connell J" first="Jeffrey R." last="O'Connell">Jeffrey R. O'Connell</name><affiliation wicri:level="1"><nlm:aff id="a32"><institution>Department of Medicine, University of Maryland School of Medicine</institution>, 685 West Baltimore Street, Baltimore, Maryland 21201,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Susztak, Katalin" sort="Susztak, Katalin" uniqKey="Susztak K" first="Katalin" last="Susztak">Katalin Susztak</name><affiliation wicri:level="1"><nlm:aff id="a18"><institution>Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania</institution>, 415 Curie Boulevard, 405B Clinical Research Building, Philadelphia, Pennsylvania 19104-4539,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hamet, Pavel" sort="Hamet, Pavel" uniqKey="Hamet P" first="Pavel" last="Hamet">Pavel Hamet</name><affiliation wicri:level="1"><nlm:aff id="a166"><institution>CRCHUM, University of Montreal, CHUM Research Center, Technopôle Angus</institution>, 900 Saint-Denis, Montreal, Québec,<country>Canada</country> H2X 0A9</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tremblay, Johanne" sort="Tremblay, Johanne" uniqKey="Tremblay J" first="Johanne" last="Tremblay">Johanne Tremblay</name><affiliation wicri:level="1"><nlm:aff id="a166"><institution>CRCHUM, University of Montreal, CHUM Research Center, Technopôle Angus</institution>, 900 Saint-Denis, Montreal, Québec,<country>Canada</country> H2X 0A9</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De Boer, Ian H" sort="De Boer, Ian H" uniqKey="De Boer I" first="Ian H." last="De Boer">Ian H. De Boer</name><affiliation wicri:level="1"><nlm:aff id="a154"><institution>Kidney Research Institute, University of Washington</institution>, Box 359606, 325 9th Avenue, Seattle, Washington 98104,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boger, Carsten A" sort="Boger, Carsten A" uniqKey="Boger C" first="Carsten A." last="Böger">Carsten A. Böger</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Department of Nephrology, University Hospital Regensburg</institution>, Franz-Josef-Strauß-Allee 11, Regensburg 93053,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Goessling, Wolfram" sort="Goessling, Wolfram" uniqKey="Goessling W" first="Wolfram" last="Goessling">Wolfram Goessling</name><affiliation wicri:level="1"><nlm:aff id="a9"><institution>Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School</institution>, New Research Building77 Avenue Louis Pasteur, Room 458, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Preventive Medicine, Brigham and Women's Hospital</institution>, 900 Commonwealth Avenue East, Boston, Massachusetts 02215,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a145"><institution>Harvard Medical School</institution>, 900 Commonwealth Avenue East, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kottgen, Anna" sort="Kottgen, Anna" uniqKey="Kottgen A" first="Anna" last="Köttgen">Anna Köttgen</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health</institution>, 615 North Wolfe Street, Baltimore, Maryland 21205,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a11"><institution>Department of Internal Medicine IV, University Hospital Freiburg</institution>, Berliner Allee 29, Freiburg 79110,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kao, W H Linda" sort="Kao, W H Linda" uniqKey="Kao W" first="W. H. Linda" last="Kao">W. H. Linda Kao</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health</institution>, 615 North Wolfe Street, Baltimore, Maryland 21205,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a113"><institution>Welch Center for Prevention, Epidemiology and Clinical Research</institution>, 2024 East Monument St, Suite 2-600, Baltimore, Maryland 21287,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fox, Caroline S" sort="Fox, Caroline S" uniqKey="Fox C" first="Caroline S." last="Fox">Caroline S. Fox</name><affiliation wicri:level="1"><nlm:aff id="a17"><institution>NHLBI's Framingham Heart Study and the Center for Population Studies</institution>, 73 Mt Wayte Avenue, Suite 2, Framingham, Massachusetts 01702,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a167"><institution>Division of Endocrinology, Brigham and Women s Hospital, Harvard Medical School</institution>, 221 Longwood Avenue, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26831199</idno><idno type="pmc">4735748</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735748</idno><idno type="RBID">PMC:4735748</idno><idno type="doi">10.1038/ncomms10023</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000755</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000755</idno><idno type="wicri:Area/Pmc/Curation">000754</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000754</idno><idno type="wicri:Area/Pmc/Checkpoint">000917</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000917</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function</title><author><name sortKey="Pattaro, Cristian" sort="Pattaro, Cristian" uniqKey="Pattaro C" first="Cristian" last="Pattaro">Cristian Pattaro</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck</institution>, Via Galvani 31, Bolzano 39100,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald</institution>, Friedrich-Loeffler-Straße 15a, Greifswald 17487,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Institute for Community Medicine, University of Greifswald</institution>, Walther-Rathenau-Strasse 48, Greifswald 17487,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gorski, Mathias" sort="Gorski, Mathias" uniqKey="Gorski M" first="Mathias" last="Gorski">Mathias Gorski</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg</institution>, Franz-Josef-Strauß-Allee 11, Regensburg 93053,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Department of Nephrology, University Hospital Regensburg</institution>, Franz-Josef-Strauß-Allee 11, Regensburg 93053,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chu, Audrey Y" sort="Chu, Audrey Y" uniqKey="Chu A" first="Audrey Y." last="Chu">Audrey Y. Chu</name><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Preventive Medicine, Brigham and Women's Hospital</institution>, 900 Commonwealth Avenue East, Boston, Massachusetts 02215,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Li, Man" sort="Li, Man" uniqKey="Li M" first="Man" last="Li">Man Li</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health</institution>, 615 North Wolfe Street, Baltimore, Maryland 21205,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mijatovic, Vladan" sort="Mijatovic, Vladan" uniqKey="Mijatovic V" first="Vladan" last="Mijatovic">Vladan Mijatovic</name><affiliation wicri:level="1"><nlm:aff id="a8"><institution>Department of Life and Reproduction Sciences, University of Verona</institution>, Strada Le Grazie 8, Verona 37134,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Garnaas, Maija" sort="Garnaas, Maija" uniqKey="Garnaas M" first="Maija" last="Garnaas">Maija Garnaas</name><affiliation wicri:level="1"><nlm:aff id="a9"><institution>Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School</institution>, New Research Building77 Avenue Louis Pasteur, Room 458, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tin, Adrienne" sort="Tin, Adrienne" uniqKey="Tin A" first="Adrienne" last="Tin">Adrienne Tin</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health</institution>, 615 North Wolfe Street, Baltimore, Maryland 21205,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sorice, Rossella" sort="Sorice, Rossella" uniqKey="Sorice R" first="Rossella" last="Sorice">Rossella Sorice</name><affiliation wicri:level="1"><nlm:aff id="a10"><institution>Institute of Genetics and Biophysics "Adriano Buzzati-Traverso"—CNR</institution>, Via P. Castellino 111, Napoli 80131,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Li, Yong" sort="Li, Yong" uniqKey="Li Y" first="Yong" last="Li">Yong Li</name><affiliation wicri:level="1"><nlm:aff id="a11"><institution>Department of Internal Medicine IV, University Hospital Freiburg</institution>, Berliner Allee 29, Freiburg 79110,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Taliun, Daniel" sort="Taliun, Daniel" uniqKey="Taliun D" first="Daniel" last="Taliun">Daniel Taliun</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck</institution>, Via Galvani 31, Bolzano 39100,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Olden, Matthias" sort="Olden, Matthias" uniqKey="Olden M" first="Matthias" last="Olden">Matthias Olden</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg</institution>, Franz-Josef-Strauß-Allee 11, Regensburg 93053,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Department of Nephrology, University Hospital Regensburg</institution>, Franz-Josef-Strauß-Allee 11, Regensburg 93053,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Foster, Meredith" sort="Foster, Meredith" uniqKey="Foster M" first="Meredith" last="Foster">Meredith Foster</name><affiliation wicri:level="1"><nlm:aff id="a12"><institution>Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Tufts Medical Center</institution>, Boston, Massachusetts 02111,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name><affiliation wicri:level="1"><nlm:aff id="a13"><institution>Department of Biostatistics, Boston University School of Public Health</institution>, 715 Albany Street, Boston, Massachusetts 02118,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Ming Huei" sort="Chen, Ming Huei" uniqKey="Chen M" first="Ming-Huei" last="Chen">Ming-Huei Chen</name><affiliation wicri:level="1"><nlm:aff id="a13"><institution>Department of Biostatistics, Boston University School of Public Health</institution>, 715 Albany Street, Boston, Massachusetts 02118,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a14"><institution>Department of Neurology, Boston University School of Medicine</institution>, 72 East Concord ST B603, Boston, Massachusetts 02118,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pers, Tune H" sort="Pers, Tune H" uniqKey="Pers T" first="Tune H." last="Pers">Tune H. Pers</name><affiliation wicri:level="1"><nlm:aff id="a15"><institution>Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital</institution>, 300 Longwood Avenue, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a16"><institution>Medical and Population Genetics Program, Broad Institute of MIT and Harvard</institution>, Cambridge, Massachusetts 2142,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Johnson, Andrew D" sort="Johnson, Andrew D" uniqKey="Johnson A" first="Andrew D." last="Johnson">Andrew D. Johnson</name><affiliation wicri:level="1"><nlm:aff id="a17"><institution>NHLBI's Framingham Heart Study and the Center for Population Studies</institution>, 73 Mt Wayte Avenue, Suite 2, Framingham, Massachusetts 01702,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ko, Yi An" sort="Ko, Yi An" uniqKey="Ko Y" first="Yi-An" last="Ko">Yi-An Ko</name><affiliation wicri:level="1"><nlm:aff id="a18"><institution>Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania</institution>, 415 Curie Boulevard, 405B Clinical Research Building, Philadelphia, Pennsylvania 19104-4539,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fuchsberger, Christian" sort="Fuchsberger, Christian" uniqKey="Fuchsberger C" first="Christian" last="Fuchsberger">Christian Fuchsberger</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck</institution>, Via Galvani 31, Bolzano 39100,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tayo, Bamidele" sort="Tayo, Bamidele" uniqKey="Tayo B" first="Bamidele" last="Tayo">Bamidele Tayo</name><affiliation wicri:level="1"><nlm:aff id="a19"><institution>Department of Public Health Sciences, Loyola Medical Center</institution>, 2160 S First Avenue, Maywood, Illinois 60153,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nalls, Michael" sort="Nalls, Michael" uniqKey="Nalls M" first="Michael" last="Nalls">Michael Nalls</name><affiliation wicri:level="1"><nlm:aff id="a20"><institution>Laboratory of Neurogenetics</institution>, Building 35—Porter Building, 1A1015, National Institute on Aging/NIH, Bethesda, Maryland 20892,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Feitosa, Mary F" sort="Feitosa, Mary F" uniqKey="Feitosa M" first="Mary F." last="Feitosa">Mary F. Feitosa</name><affiliation wicri:level="1"><nlm:aff id="a21"><institution>Division of Statistical Genomics, Washington University School of Medicine</institution>, 4444 Forest Park Boulevard, Box 8506, St Louis, Missouri 63108,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Isaacs, Aaron" sort="Isaacs, Aaron" uniqKey="Isaacs A" first="Aaron" last="Isaacs">Aaron Isaacs</name><affiliation wicri:level="1"><nlm:aff id="a22"><institution>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center</institution>, Dr Molewaterplein 50, PO Box 2040, Rotterdam 3000 CA,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a23"><institution>Centre for Medical Systems Biology Leiden</institution>, Dr Molewaterplein 50, PO Box 2040, Rotterdam 3000 CA,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name><affiliation wicri:level="1"><nlm:aff id="a24"><institution>Department of Epidemiology, Erasmus University Medical Center</institution>, PO Box 2040, Rotterdam 3000 CA,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="D Adamo, Pio" sort="D Adamo, Pio" uniqKey="D Adamo P" first="Pio" last="D'Adamo">Pio D'Adamo</name><affiliation wicri:level="1"><nlm:aff id="a25"><institution>Institute for Maternal and Child Health—IRCCS "Burlo Garofolo" and University of Trieste</institution>, via dell'Istria 65/1, Trieste 34137,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Adeyemo, Adebowale" sort="Adeyemo, Adebowale" uniqKey="Adeyemo A" first="Adebowale" last="Adeyemo">Adebowale Adeyemo</name><affiliation wicri:level="1"><nlm:aff id="a26"><institution>Center for Research on Genomics and Global Health, National Human Genome Research Institute</institution>, Building 12A, Room 4047, 12 South Dr, MSC 5635, Bethesda, Maryland 20892-5635,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dieffenbach, Aida Karina" sort="Dieffenbach, Aida Karina" uniqKey="Dieffenbach A" first="Aida Karina" last="Dieffenbach">Aida Karina Dieffenbach</name><affiliation wicri:level="1"><nlm:aff id="a27"><institution>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)</institution>, Im Neuenheimer Feld 581, Heidelberg 69120,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a28"><institution>German Cancer Consortium (DKTK)</institution>, Im Neuenheimer Feld 581, Heidelberg 69120,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zonderman, Alan B" sort="Zonderman, Alan B" uniqKey="Zonderman A" first="Alan B." last="Zonderman">Alan B. Zonderman</name><affiliation wicri:level="1"><nlm:aff id="a29"><institution>Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, NIH Biomedical Center</institution>, 251 Bayview Boulevard, Suite 100, Baltimore, Maryland 21224,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nolte, Ilja M" sort="Nolte, Ilja M" uniqKey="Nolte I" first="Ilja M." last="Nolte">Ilja M. Nolte</name><affiliation wicri:level="1"><nlm:aff id="a30"><institution>Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen</institution>, PO Box 30001, Groningen 9700 RB,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Most, Peter J" sort="Van Der Most, Peter J" uniqKey="Van Der Most P" first="Peter J." last="Van Der Most">Peter J. Van Der Most</name><affiliation wicri:level="1"><nlm:aff id="a30"><institution>Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen</institution>, PO Box 30001, Groningen 9700 RB,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F." last="Wright">Alan F. Wright</name><affiliation wicri:level="1"><nlm:aff id="a31"><institution>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>, Crewe Road, Edinburgh EH4 2XU,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R." last="Shuldiner">Alan R. Shuldiner</name><affiliation wicri:level="1"><nlm:aff id="a32"><institution>Department of Medicine, University of Maryland School of Medicine</institution>, 685 West Baltimore Street, Baltimore, Maryland 21201,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a33"><institution>Geriatric Research and Education Clinical Center, Veterans Administration Medical Center</institution>, 10 North Greene Street, Baltimore, Maryland 21201,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Morrison, Alanna C" sort="Morrison, Alanna C" uniqKey="Morrison A" first="Alanna C." last="Morrison">Alanna C. Morrison</name><affiliation wicri:level="1"><nlm:aff id="a34"><institution>Human Genetics Center, University of Texas Health Science Center at Houston</institution>, 1200 Pressler St Suite 453E, Houston, Texas 77030,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="1"><nlm:aff id="a24"><institution>Department of Epidemiology, Erasmus University Medical Center</institution>, PO Box 2040, Rotterdam 3000 CA,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V." last="Smith">Albert V. Smith</name><affiliation wicri:level="1"><nlm:aff id="a35"><institution>Icelandic Heart Association, Research Institute</institution>, Holtasmari 1, Kopavogur 201,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a36"><institution>University of Iceland</institution>, Sæmundargötu 2, Reykjavik 101,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dreisbach, Albert W" sort="Dreisbach, Albert W" uniqKey="Dreisbach A" first="Albert W." last="Dreisbach">Albert W. Dreisbach</name><affiliation wicri:level="1"><nlm:aff id="a37"><institution>Division of Nephrology, University of Mississippi</institution>, 2500 North State Street, Jackson, Mississippi 39216,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Franke, Andre" sort="Franke, Andre" uniqKey="Franke A" first="Andre" last="Franke">Andre Franke</name><affiliation wicri:level="1"><nlm:aff id="a38"><institution>Institute of Clinical Molecular Biology, Christian-Albrechts University of Kiel</institution>, Schittenhelmstraße 12, Kiel 24105,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><affiliation wicri:level="1"><nlm:aff id="a39"><institution>Department of Internal Medicine, Erasmus University Medical Center</institution>, PO Box 1738, Rotterdam 3000 DR,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation wicri:level="1"><nlm:aff id="a40"><institution>Estonian Genome Center of University of Tartu (EGCUT)</institution>, Riia 23B, Tartu 51010,<country>Estonia</country></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a41"><institution>Institute of Molecular and Cell Biology, University of Tartu and Estonian Biocenter</institution>, Riia 23, Tartu 51010,<country>Estonia</country></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tonjes, Anke" sort="Tonjes, Anke" uniqKey="Tonjes A" first="Anke" last="Tonjes">Anke Tonjes</name><affiliation wicri:level="1"><nlm:aff id="a42"><institution>Department of Medicine, University of Leipzig</institution>, Liebigstraße 18, Leipzig 04103,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lupo, Antonio" sort="Lupo, Antonio" uniqKey="Lupo A" first="Antonio" last="Lupo">Antonio Lupo</name><affiliation wicri:level="1"><nlm:aff id="a43"><institution>Division of Nephrology, Department of Medicine, University of Verona</institution>, Piazzale Aristide Stefani 1, Verona 37126,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Robino, Antonietta" sort="Robino, Antonietta" uniqKey="Robino A" first="Antonietta" last="Robino">Antonietta Robino</name><affiliation wicri:level="1"><nlm:aff id="a25"><institution>Institute for Maternal and Child Health—IRCCS "Burlo Garofolo" and University of Trieste</institution>, via dell'Istria 65/1, Trieste 34137,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name><affiliation wicri:level="1"><nlm:aff id="a44"><institution>Uppsala University, Department of Immunology, Genetics and Pathology, Biomedical Center, SciLifeLab, Uppsala University</institution>, Uppsala SE- 75108,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Demirkan, Ayse" sort="Demirkan, Ayse" uniqKey="Demirkan A" first="Ayse" last="Demirkan">Ayse Demirkan</name><affiliation wicri:level="1"><nlm:aff id="a22"><institution>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center</institution>, Dr Molewaterplein 50, PO Box 2040, Rotterdam 3000 CA,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kollerits, Barbara" sort="Kollerits, Barbara" uniqKey="Kollerits B" first="Barbara" last="Kollerits">Barbara Kollerits</name><affiliation wicri:level="1"><nlm:aff id="a45"><institution>Innsbruck Medical University, Division of Genetic Epidemiology</institution>, Schoepfstraße 41, Innsbruck 6020,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Freedman, Barry I" sort="Freedman, Barry I" uniqKey="Freedman B" first="Barry I." last="Freedman">Barry I. Freedman</name><affiliation wicri:level="1"><nlm:aff id="a46"><institution>Internal Medicine Department, Wake Forest School of Medicine</institution>, Medical Center Boulevard, Winston-Salem, North Carolina 27157-1053,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ponte, Belen" sort="Ponte, Belen" uniqKey="Ponte B" first="Belen" last="Ponte">Belen Ponte</name><affiliation wicri:level="1"><nlm:aff id="a47"><institution>Nephrology Division, Department of Specialties of Internal Medicine, Geneva University Hospital</institution>, 4 rue Gabrielle-Perret-Gentil, Geneve 1211,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name><affiliation wicri:level="1"><nlm:aff id="a48"><institution>Department of Clinical Genetics, Erasmus University Medical Center</institution>, Dr Molewaterplein 50, PO Box 2040, Rotterdam 3000 CA,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Paulweber, Bernhard" sort="Paulweber, Bernhard" uniqKey="Paulweber B" first="Bernhard" last="Paulweber">Bernhard Paulweber</name><affiliation wicri:level="1"><nlm:aff id="a49"><institution>First Department of Internal Medicine, Paracelsus Medical University/Salzburger Landeskliniken</institution>, Müllner Hauptstraße 48, Salzburg 5020,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kr Mer, Bernhard K" sort="Kr Mer, Bernhard K" uniqKey="Kr Mer B" first="Bernhard K." last="Kr Mer">Bernhard K. Kr Mer</name><affiliation wicri:level="1"><nlm:aff id="a50"><institution>University Medical Centre Mannheim, 5th Department of Medicine, University of Heidelberg</institution>, Theodor Kutzer Ufer 1-3, Mannheim 68167,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name><affiliation wicri:level="1"><nlm:aff id="a32"><institution>Department of Medicine, University of Maryland School of Medicine</institution>, 685 West Baltimore Street, Baltimore, Maryland 21201,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a33"><institution>Geriatric Research and Education Clinical Center, Veterans Administration Medical Center</institution>, 10 North Greene Street, Baltimore, Maryland 21201,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Buckley, Brendan M" sort="Buckley, Brendan M" uniqKey="Buckley B" first="Brendan M." last="Buckley">Brendan M. Buckley</name><affiliation wicri:level="1"><nlm:aff id="a51"><institution>Department of Pharmacology and Therapeutics, University College Cork, Clinical Investigations Building</institution>, Western Rd, Cork,<country>Ireland</country></nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peralta, Carmen A" sort="Peralta, Carmen A" uniqKey="Peralta C" first="Carmen A." last="Peralta">Carmen A. Peralta</name><affiliation wicri:level="1"><nlm:aff id="a52"><institution>Division of Nephrology, University of California, San Francisco Medical School and San Francisco VA Medical Center</institution>, 4150 Clement Street, San Francisco, California 94121,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation wicri:level="1"><nlm:aff id="a31"><institution>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>, Crewe Road, Edinburgh EH4 2XU,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Helmer, Catherine" sort="Helmer, Catherine" uniqKey="Helmer C" first="Catherine" last="Helmer">Catherine Helmer</name><affiliation wicri:level="1"><nlm:aff id="a53"><institution>INSERM, ISPED, Centre INSERM U897—Epidemiologie-Biostatistique</institution>, Bordeaux F-33000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a54"><institution>Université Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique</institution>, Bordeaux F-33000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rotimi, Charles N" sort="Rotimi, Charles N" uniqKey="Rotimi C" first="Charles N." last="Rotimi">Charles N. Rotimi</name><affiliation wicri:level="1"><nlm:aff id="a26"><institution>Center for Research on Genomics and Global Health, National Human Genome Research Institute</institution>, Building 12A, Room 4047, 12 South Dr, MSC 5635, Bethesda, Maryland 20892-5635,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shaffer, Christian M" sort="Shaffer, Christian M" uniqKey="Shaffer C" first="Christian M." last="Shaffer">Christian M. Shaffer</name><affiliation wicri:level="1"><nlm:aff id="a55"><institution>Vanderbilt University School of Medicine</institution>, 2215-B Garland Avenue 1224—MRB4 (Light Hall)Nashville, Tennessee 37232,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Muller, Christian" sort="Muller, Christian" uniqKey="Muller C" first="Christian" last="Müller">Christian Müller</name><affiliation wicri:level="1"><nlm:aff id="a56"><institution>University Heart Center Hamburg, Clinic for general and interventional cardiology</institution>, Martinistraße 52, Hamburg 20246,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a57"><institution>German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Lübeck/Kiel</institution>, Martinistraße 52, Hamburg 20246, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>, Martinistraße 52, Hamburg 20246</wicri:regionArea><wicri:noRegion>20246</wicri:noRegion><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Sala, Cinzia" sort="Sala, Cinzia" uniqKey="Sala C" first="Cinzia" last="Sala">Cinzia Sala</name><affiliation wicri:level="1"><nlm:aff id="a58"><institution>Division of Genetics and Cell Biology, San Raffaele Scientific Institute</institution>, Via Olgettina 58, Milano 20132,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><affiliation wicri:level="1"><nlm:aff id="a22"><institution>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center</institution>, Dr Molewaterplein 50, PO Box 2040, Rotterdam 3000 CA,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Saint Pierre, Aude" sort="Saint Pierre, Aude" uniqKey="Saint Pierre A" first="Aude" last="Saint-Pierre">Aude Saint-Pierre</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck</institution>, Via Galvani 31, Bolzano 39100,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a59"><institution>INSERM U1078, Etablissement Français du Sang</institution>, 46 rue Félix Le Dantec, CS 51819, Brest Cedex 2 29218,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ackermann, Daniel" sort="Ackermann, Daniel" uniqKey="Ackermann D" first="Daniel" last="Ackermann">Daniel Ackermann</name><affiliation wicri:level="1"><nlm:aff id="a47"><institution>Nephrology Division, Department of Specialties of Internal Medicine, Geneva University Hospital</institution>, 4 rue Gabrielle-Perret-Gentil, Geneve 1211,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shriner, Daniel" sort="Shriner, Daniel" uniqKey="Shriner D" first="Daniel" last="Shriner">Daniel Shriner</name><affiliation wicri:level="1"><nlm:aff id="a26"><institution>Center for Research on Genomics and Global Health, National Human Genome Research Institute</institution>, Building 12A, Room 4047, 12 South Dr, MSC 5635, Bethesda, Maryland 20892-5635,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ruggiero, Daniela" sort="Ruggiero, Daniela" uniqKey="Ruggiero D" first="Daniela" last="Ruggiero">Daniela Ruggiero</name><affiliation wicri:level="1"><nlm:aff id="a10"><institution>Institute of Genetics and Biophysics "Adriano Buzzati-Traverso"—CNR</institution>, Via P. Castellino 111, Napoli 80131,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Toniolo, Daniela" sort="Toniolo, Daniela" uniqKey="Toniolo D" first="Daniela" last="Toniolo">Daniela Toniolo</name><affiliation wicri:level="1"><nlm:aff id="a58"><institution>Division of Genetics and Cell Biology, San Raffaele Scientific Institute</institution>, Via Olgettina 58, Milano 20132,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a60"><institution>Institute of Molecular Genetics-CNR</institution>, Via Abbiategrasso 207, Pavia 27100,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lu, Yingchang" sort="Lu, Yingchang" uniqKey="Lu Y" first="Yingchang" last="Lu">Yingchang Lu</name><affiliation wicri:level="1"><nlm:aff id="a61"><institution>The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai</institution>, New York, New York 10029,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cusi, Daniele" sort="Cusi, Daniele" uniqKey="Cusi D" first="Daniele" last="Cusi">Daniele Cusi</name><affiliation wicri:level="1"><nlm:aff id="a62"><institution>Department of Health Sciences, University of Milano</institution>, Via Antonio di Rudinì 8, Milano 20142,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Czamara, Darina" sort="Czamara, Darina" uniqKey="Czamara D" first="Darina" last="Czamara">Darina Czamara</name><affiliation wicri:level="1"><nlm:aff id="a63"><institution>Max Planck Institute of Psychiatry</institution>, Kraepelinstraße 2–10, Munich 80804,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ellinghaus, David" sort="Ellinghaus, David" uniqKey="Ellinghaus D" first="David" last="Ellinghaus">David Ellinghaus</name><affiliation wicri:level="1"><nlm:aff id="a38"><institution>Institute of Clinical Molecular Biology, Christian-Albrechts University of Kiel</institution>, Schittenhelmstraße 12, Kiel 24105,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S." last="Siscovick">David S. Siscovick</name><affiliation wicri:level="1"><nlm:aff id="a64"><institution>Cardiovascular Health Research Unit, Departments of Epidemiology and Medicine, University of Washington</institution>, 1730 Minor Ave, Suite 1360, Seattle, Washington 98101,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ruderfer, Douglas" sort="Ruderfer, Douglas" uniqKey="Ruderfer D" first="Douglas" last="Ruderfer">Douglas Ruderfer</name><affiliation wicri:level="1"><nlm:aff id="a65"><institution>Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai</institution>, New York, New York 10029,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation wicri:level="1"><nlm:aff id="a66"><institution>Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health</institution>, Ingolstaedter Landstraße 1, 85764 Neuherberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Grallert, Harald" sort="Grallert, Harald" uniqKey="Grallert H" first="Harald" last="Grallert">Harald Grallert</name><affiliation wicri:level="1"><nlm:aff id="a67"><institution>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health</institution>, Ingolstaedter Landstraße 1, 85764 Neuherberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a68"><institution>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health</institution>, 85764 Neuherberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a69"><institution>German Center for Diabetes Research (DZD)</institution>, Ingolstaedter Landstraße 1, Neuherberg 85764,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rochtchina, Elena" sort="Rochtchina, Elena" uniqKey="Rochtchina E" first="Elena" last="Rochtchina">Elena Rochtchina</name><affiliation wicri:level="1"><nlm:aff id="a70"><institution>Westmead Millennium Institute, Centre for Vision Research, University of Sydney</institution>, C24 Westmead Hospital, New South Wales 2145,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Atkinson, Elizabeth J" sort="Atkinson, Elizabeth J" uniqKey="Atkinson E" first="Elizabeth J." last="Atkinson">Elizabeth J. Atkinson</name><affiliation wicri:level="1"><nlm:aff id="a71"><institution>Division of Biomedical Statistics and Informatics, Mayo Clinic</institution>, 200 First Street SW, Rochester, Minnesota 55905,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name><affiliation wicri:level="1"><nlm:aff id="a72"><institution>Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, HMRI Building1, Kookaburra Circuit</institution>, New Lambton New South Wales 2305,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a73"><institution>Clinical Research Design, Information Technology and Statistical Support, Hunter Medical Research Institute, Newcastle</institution>, 1 Kookaburra Circuit, New Lambton Heights, New South Wales 2305,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation wicri:level="1"><nlm:aff id="a34"><institution>Human Genetics Center, University of Texas Health Science Center at Houston</institution>, 1200 Pressler St Suite 453E, Houston, Texas 77030,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Salvi, Erika" sort="Salvi, Erika" uniqKey="Salvi E" first="Erika" last="Salvi">Erika Salvi</name><affiliation wicri:level="1"><nlm:aff id="a62"><institution>Department of Health Sciences, University of Milano</institution>, Via Antonio di Rudinì 8, Milano 20142,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bottinger, Erwin P" sort="Bottinger, Erwin P" uniqKey="Bottinger E" first="Erwin P." last="Bottinger">Erwin P. Bottinger</name><affiliation wicri:level="1"><nlm:aff id="a61"><institution>The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai</institution>, New York, New York 10029,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Murgia, Federico" sort="Murgia, Federico" uniqKey="Murgia F" first="Federico" last="Murgia">Federico Murgia</name><affiliation wicri:level="1"><nlm:aff id="a74"><institution>Institute of Population Genetics—CNR</institution>, Traversa La Crucca 3, 07040 Reg. Baldinca, Li Punti, Sassari,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation wicri:level="1"><nlm:aff id="a39"><institution>Department of Internal Medicine, Erasmus University Medical Center</institution>, PO Box 1738, Rotterdam 3000 DR,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ernst, Florian" sort="Ernst, Florian" uniqKey="Ernst F" first="Florian" last="Ernst">Florian Ernst</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald</institution>, Friedrich-Loeffler-Straße 15a, Greifswald 17487,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kronenberg, Florian" sort="Kronenberg, Florian" uniqKey="Kronenberg F" first="Florian" last="Kronenberg">Florian Kronenberg</name><affiliation wicri:level="1"><nlm:aff id="a45"><institution>Innsbruck Medical University, Division of Genetic Epidemiology</institution>, Schoepfstraße 41, Innsbruck 6020,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hu, Frank B" sort="Hu, Frank B" uniqKey="Hu F" first="Frank B." last="Hu">Frank B. Hu</name><affiliation wicri:level="1"><nlm:aff id="a75"><institution>Department of Nutrition, Harvard School of Public Health</institution>, 665 Huntington Avenue, Building 2, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Navis, Gerjan J" sort="Navis, Gerjan J" uniqKey="Navis G" first="Gerjan J." last="Navis">Gerjan J. Navis</name><affiliation wicri:level="1"><nlm:aff id="a76"><institution>Department of Internal Medicine, University Medical Center Groningen, University of Groningen</institution>, Hanzeplein 1, Groningen 9713 GZ,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Curhan, Gary C" sort="Curhan, Gary C" uniqKey="Curhan G" first="Gary C." last="Curhan">Gary C. Curhan</name><affiliation wicri:level="1"><nlm:aff id="a77"><institution>Brigham and Women's Hospital and Channing Laboratory, Harvard Medical School</institution>, 181 Longwood Avenue, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ehret, George B" sort="Ehret, George B" uniqKey="Ehret G" first="George B." last="Ehret">George B. Ehret</name><affiliation wicri:level="1"><nlm:aff id="a78"><institution>Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospitals</institution>, Rue Gabrielle-Perret-Gentil 4, Geneva 1205,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald</institution>, Friedrich-Loeffler-Straße 15a, Greifswald 17487,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Coassin, Stefan" sort="Coassin, Stefan" uniqKey="Coassin S" first="Stefan" last="Coassin">Stefan Coassin</name><affiliation wicri:level="1"><nlm:aff id="a45"><institution>Innsbruck Medical University, Division of Genetic Epidemiology</institution>, Schoepfstraße 41, Innsbruck 6020,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Thun, Gian Andri" sort="Thun, Gian Andri" uniqKey="Thun G" first="Gian-Andri" last="Thun">Gian-Andri Thun</name><affiliation wicri:level="1"><nlm:aff id="a79"><institution>Swiss Tropical and Public Health Institute</institution>, PO Box 4002, Basel,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a80"><institution>University of Basel</institution>, Petersplatz 1, Basel 4003,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pistis, Giorgio" sort="Pistis, Giorgio" uniqKey="Pistis G" first="Giorgio" last="Pistis">Giorgio Pistis</name><affiliation wicri:level="1"><nlm:aff id="a58"><institution>Division of Genetics and Cell Biology, San Raffaele Scientific Institute</institution>, Via Olgettina 58, Milano 20132,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gambaro, Giovanni" sort="Gambaro, Giovanni" uniqKey="Gambaro G" first="Giovanni" last="Gambaro">Giovanni Gambaro</name><affiliation wicri:level="1"><nlm:aff id="a81"><institution>Division of Nephrology, Department of Internal Medicine and Medical Specialties, Columbus-Gemelli University Hospital, Catholic University</institution>, Via Moscati 31, Rome 00168,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Malerba, Giovanni" sort="Malerba, Giovanni" uniqKey="Malerba G" first="Giovanni" last="Malerba">Giovanni Malerba</name><affiliation wicri:level="1"><nlm:aff id="a8"><institution>Department of Life and Reproduction Sciences, University of Verona</institution>, Strada Le Grazie 8, Verona 37134,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><affiliation wicri:level="1"><nlm:aff id="a82"><institution>Genetic Epidemiology, Queensland Institute of Medical Research, QIMR, PO Royal Brisbane Hospital</institution>, Queensland 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name><affiliation wicri:level="1"><nlm:aff id="a35"><institution>Icelandic Heart Association, Research Institute</institution>, Holtasmari 1, Kopavogur 201,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jacobs, Gunnar" sort="Jacobs, Gunnar" uniqKey="Jacobs G" first="Gunnar" last="Jacobs">Gunnar Jacobs</name><affiliation wicri:level="1"><nlm:aff id="a83"><institution>Institute of Epidemiology and Biobank popgen, Christian-Albrechts University</institution>, Niemannsweg 11, Kiel 24105,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Li, Guo" sort="Li, Guo" uniqKey="Li G" first="Guo" last="Li">Guo Li</name><affiliation wicri:level="1"><nlm:aff id="a64"><institution>Cardiovascular Health Research Unit, Departments of Epidemiology and Medicine, University of Washington</institution>, 1730 Minor Ave, Suite 1360, Seattle, Washington 98101,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H-Erich" last="Wichmann">H-Erich Wichmann</name><affiliation wicri:level="1"><nlm:aff id="a84"><institution>Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health</institution>, Ingolstädter Landstraße 1, Neuherberg 85764,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a85"><institution>Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Ingolstädter Landstrasse 1</institution>, 85764 Neuherberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a86"><institution>Klinikum Grosshadern</institution>, Ingolstädter Landstraße 1, Neuherberg 85764,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation wicri:level="1"><nlm:aff id="a87"><institution>Centre for Population Health Sciences, University of Edinburgh</institution>, Teviot Place, Edinburgh, EH8 9AG Scotland,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><affiliation wicri:level="1"><nlm:aff id="a88"><institution>Austrian Stroke Prevention Study, Institute of Molecular Biology and Biochemistry, Department of Neurology, Medical University Graz</institution>, Harrachgasse 21, Graz 8010,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wallaschofski, Henri" sort="Wallaschofski, Henri" uniqKey="Wallaschofski H" first="Henri" last="Wallaschofski">Henri Wallaschofski</name><affiliation wicri:level="1"><nlm:aff id="a89"><institution>Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald</institution>, Ferdinand-Sauerbruch-Straße, Greifswald 17475,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a90"><institution>German Center for Cardiovascular Research (DZHK)</institution>, Partner site Greifswald, Ferdinand-Sauerbruch-Straße, Greifswald 17475,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Institute for Community Medicine, University of Greifswald</institution>, Walther-Rathenau-Strasse 48, Greifswald 17487,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a90"><institution>German Center for Cardiovascular Research (DZHK)</institution>, Partner site Greifswald, Ferdinand-Sauerbruch-Straße, Greifswald 17475,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="1"><nlm:aff id="a27"><institution>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)</institution>, Im Neuenheimer Feld 581, Heidelberg 69120,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a28"><institution>German Cancer Consortium (DKTK)</institution>, Im Neuenheimer Feld 581, Heidelberg 69120,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kroemer, Heyo K" sort="Kroemer, Heyo K" uniqKey="Kroemer H" first="Heyo K." last="Kroemer">Heyo K. Kroemer</name><affiliation wicri:level="1"><nlm:aff id="a91"><institution>Institute of Pharmacology, University of Greifswald</institution>, Friedrich-Loeffler-Straße 23d, Greifswald 17487,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kramer, Holly" sort="Kramer, Holly" uniqKey="Kramer H" first="Holly" last="Kramer">Holly Kramer</name><affiliation wicri:level="1"><nlm:aff id="a19"><institution>Department of Public Health Sciences, Loyola Medical Center</institution>, 2160 S First Avenue, Maywood, Illinois 60153,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lin, Honghuang" sort="Lin, Honghuang" uniqKey="Lin H" first="Honghuang" last="Lin">Honghuang Lin</name><affiliation wicri:level="1"><nlm:aff id="a92"><institution>Boston University School of Medicine</institution>, 72 East Concord Street, B-616, Boston, Massachusetts 02118,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Leach, I Mateo" sort="Leach, I Mateo" uniqKey="Leach I" first="I. Mateo" last="Leach">I. Mateo Leach</name><affiliation wicri:level="1"><nlm:aff id="a93"><institution>Department of Cardiology, University Medical Center Groningen, University of Groningen</institution>, PO Box 30.001, Groningen 9700 RB,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name><affiliation wicri:level="1"><nlm:aff id="a94"><institution>Robertson Centre for Biostatistics, University of Glasgow</institution>, R1122B Level 11, Robertson Centre, Boyd Orr Building, Glasgow G12 8QQ,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Guessous, Idris" sort="Guessous, Idris" uniqKey="Guessous I" first="Idris" last="Guessous">Idris Guessous</name><affiliation wicri:level="1"><nlm:aff id="a95"><institution>Division of Primary Care Medicine, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals, Faculty of Medicine, University of Geneva</institution>, Geneva 1211,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a96"><institution>Community Prevention Unit, University Institute of Social and Preventive Medicine, Lausanne University Hospital</institution>, Route de la Corniche 10, Lausanne 1010,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a97"><institution>Department of Epidemiology, Rollins School of Public Health, Emory University</institution>, 1518 Clifton Road, NE, Atlanta, Georgia 30322,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation wicri:level="1"><nlm:aff id="a87"><institution>Centre for Population Health Sciences, University of Edinburgh</institution>, Teviot Place, Edinburgh, EH8 9AG Scotland,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation wicri:level="1"><nlm:aff id="a98"><institution>Department of Genomics of Common Disease, School of Public Health, Imperial College London</institution>, London W12 0NN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Borecki, Ingrid" sort="Borecki, Ingrid" uniqKey="Borecki I" first="Ingrid" last="Borecki">Ingrid Borecki</name><affiliation wicri:level="1"><nlm:aff id="a21"><institution>Division of Statistical Genomics, Washington University School of Medicine</institution>, 4444 Forest Park Boulevard, Box 8506, St Louis, Missouri 63108,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Heid, Iris M" sort="Heid, Iris M" uniqKey="Heid I" first="Iris M." last="Heid">Iris M. Heid</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg</institution>, Franz-Josef-Strauß-Allee 11, Regensburg 93053,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a66"><institution>Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health</institution>, Ingolstaedter Landstraße 1, 85764 Neuherberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kolcic, Ivana" sort="Kolcic, Ivana" uniqKey="Kolcic I" first="Ivana" last="Kolcic">Ivana Kolcic</name><affiliation wicri:level="1"><nlm:aff id="a99"><institution>Croatian Centre for Global Health, University of Split Medical School</institution>, Šoltanska 2, Split 21000,<country>Croatia</country></nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Persico, Ivana" sort="Persico, Ivana" uniqKey="Persico I" first="Ivana" last="Persico">Ivana Persico</name><affiliation wicri:level="1"><nlm:aff id="a74"><institution>Institute of Population Genetics—CNR</institution>, Traversa La Crucca 3, 07040 Reg. Baldinca, Li Punti, Sassari,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name><affiliation wicri:level="1"><nlm:aff id="a100"><institution>Department of Cardiology, Leiden University Medical Center</institution>, PO Box 9600, Leiden 2300 RC,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a101"><institution>Interuniversity Cardiology Institute of the Netherlands (ICIN)</institution>, Moreelsepark 1, Utrecht 3511 EP,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a102"><institution>Einthoven Laboratory for Experimental Vascular Medicine</institution>, Albinusdreef 2, Leiden 2333 ZA,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a103"><institution>Durrer Center for Cardiogenetic Research</institution>, Meibergdreef 9, Amsterdam 1105 AZ,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name><affiliation wicri:level="1"><nlm:aff id="a87"><institution>Centre for Population Health Sciences, University of Edinburgh</institution>, Teviot Place, Edinburgh, EH8 9AG Scotland,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Felix, Janine F" sort="Felix, Janine F" uniqKey="Felix J" first="Janine F." last="Felix">Janine F. Felix</name><affiliation wicri:level="1"><nlm:aff id="a24"><institution>Department of Epidemiology, Erasmus University Medical Center</institution>, PO Box 2040, Rotterdam 3000 CA,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Divers, Jasmin" sort="Divers, Jasmin" uniqKey="Divers J" first="Jasmin" last="Divers">Jasmin Divers</name><affiliation wicri:level="1"><nlm:aff id="a104"><institution>Division of Public Health Sciences, Department of Biostatistical Sciences, Wake Forest University Health Sciences</institution>, 2326 Medical Center Boulevard, Winston-Salem, North Carolina 27157-1063,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation wicri:level="1"><nlm:aff id="a105"><institution>INSERM U744, Institut Pasteur de Lille</institution>, 1 rue du Pr, Calmette, Lille Cédex 59019,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stafford, Jeanette M" sort="Stafford, Jeanette M" uniqKey="Stafford J" first="Jeanette M." last="Stafford">Jeanette M. Stafford</name><affiliation wicri:level="1"><nlm:aff id="a104"><institution>Division of Public Health Sciences, Department of Biostatistical Sciences, Wake Forest University Health Sciences</institution>, 2326 Medical Center Boulevard, Winston-Salem, North Carolina 27157-1063,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gaspoz, Jean Michel" sort="Gaspoz, Jean Michel" uniqKey="Gaspoz J" first="Jean-Michel" last="Gaspoz">Jean-Michel Gaspoz</name><affiliation wicri:level="1"><nlm:aff id="a95"><institution>Division of Primary Care Medicine, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals, Faculty of Medicine, University of Geneva</institution>, Geneva 1211,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Smith, Jennifer A" sort="Smith, Jennifer A" uniqKey="Smith J" first="Jennifer A." last="Smith">Jennifer A. Smith</name><affiliation wicri:level="1"><nlm:aff id="a106"><institution>Department of Epidemiology, School of Public Health, University of Michigan</institution>, 1415 Washington Heights, Ann Arbor, Michigan 48109-2029,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Faul, Jessica D" sort="Faul, Jessica D" uniqKey="Faul J" first="Jessica D." last="Faul">Jessica D. Faul</name><affiliation wicri:level="1"><nlm:aff id="a107"><institution>Survey Research Center, Institute for Social Research, University of Michigan</institution>, 426 Thompson Street, #3456, Ann Arbor, Michigan 48104,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name><affiliation wicri:level="1"><nlm:aff id="a108"><institution>Centre for Vision Research, Westmead Millennium Institute, University of Sydney</institution>, C24 Westmead Hospital, New South Wales 2145,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ding, Jingzhong" sort="Ding, Jingzhong" uniqKey="Ding J" first="Jingzhong" last="Ding">Jingzhong Ding</name><affiliation wicri:level="1"><nlm:aff id="a109"><institution>Wake Forest School of Medicine, Department of Internal Medicine/Geriatrics</institution>, Medical center Boulevard, Winston-Salem, North Carolina 27157,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N." last="Hirschhorn">Joel N. Hirschhorn</name><affiliation wicri:level="1"><nlm:aff id="a15"><institution>Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital</institution>, 300 Longwood Avenue, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a16"><institution>Medical and Population Genetics Program, Broad Institute of MIT and Harvard</institution>, Cambridge, Massachusetts 2142,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a110"><institution>Department of Genetics, Harvard Medical School</institution>, 77 Avenue Louis Pasteur, NRB 0330, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Attia, John" sort="Attia, John" uniqKey="Attia J" first="John" last="Attia">John Attia</name><affiliation wicri:level="1"><nlm:aff id="a71"><institution>Division of Biomedical Statistics and Informatics, Mayo Clinic</institution>, 200 First Street SW, Rochester, Minnesota 55905,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a72"><institution>Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, HMRI Building1, Kookaburra Circuit</institution>, New Lambton New South Wales 2305,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John B." last="Whitfield">John B. Whitfield</name><affiliation wicri:level="1"><nlm:aff id="a82"><institution>Genetic Epidemiology, Queensland Institute of Medical Research, QIMR, PO Royal Brisbane Hospital</institution>, Queensland 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name><affiliation wicri:level="1"><nlm:aff id="a111"><institution>University of Sydney, The George Institute for Global Health</institution>, Level 10, King George V Building, 83-117 Missenden Road, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Viikari, Jorma" sort="Viikari, Jorma" uniqKey="Viikari J" first="Jorma" last="Viikari">Jorma Viikari</name><affiliation wicri:level="1"><nlm:aff id="a112"><institution>Department of Medicine, University of Turku, Turku University Hospital</institution>, PO Box 52, Turku 20521,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Coresh, Josef" sort="Coresh, Josef" uniqKey="Coresh J" first="Josef" last="Coresh">Josef Coresh</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health</institution>, 615 North Wolfe Street, Baltimore, Maryland 21205,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a113"><institution>Welch Center for Prevention, Epidemiology and Clinical Research</institution>, 2024 East Monument St, Suite 2-600, Baltimore, Maryland 21287,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Denny, Joshua C" sort="Denny, Joshua C" uniqKey="Denny J" first="Joshua C." last="Denny">Joshua C. Denny</name><affiliation wicri:level="1"><nlm:aff id="a114"><institution>Vanderbilt University School of Medicine</institution>, 448 Eskind Biomedical Library, 2209 Garland Avenue, Nashville, Tennessee 37212,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Karjalainen, Juha" sort="Karjalainen, Juha" uniqKey="Karjalainen J" first="Juha" last="Karjalainen">Juha Karjalainen</name><affiliation wicri:level="1"><nlm:aff id="a115"><institution>Department of Genetics, University of Groningen, University Medical Centre Groningen</institution>, PO Box 72, Groningen 9700 AB,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fernandes, Jyotika K" sort="Fernandes, Jyotika K" uniqKey="Fernandes J" first="Jyotika K." last="Fernandes">Jyotika K. Fernandes</name><affiliation wicri:level="1"><nlm:aff id="a116"><institution>Division of Endocrinology, Medical University of South Carolina</institution>, 171 Ashley Avenue, Charleston, South Carolina 29425,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Endlich, Karlhans" sort="Endlich, Karlhans" uniqKey="Endlich K" first="Karlhans" last="Endlich">Karlhans Endlich</name><affiliation wicri:level="1"><nlm:aff id="a117"><institution>Institute of Anatomy and Cell Biology, University of Greifswald</institution>, Friedrich-Loeffler-Straße 23c, Greifswald 17487,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Butterbach, Katja" sort="Butterbach, Katja" uniqKey="Butterbach K" first="Katja" last="Butterbach">Katja Butterbach</name><affiliation wicri:level="1"><nlm:aff id="a27"><institution>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)</institution>, Im Neuenheimer Feld 581, Heidelberg 69120,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Keene, Keith L" sort="Keene, Keith L" uniqKey="Keene K" first="Keith L." last="Keene">Keith L. Keene</name><affiliation wicri:level="1"><nlm:aff id="a118"><institution>Center for Health Disparities, Department of Biology, East Carolina University</institution>, 1001 East 10th Street, N209 Howell Science Complex Mailstop 551, Greenville, North Carolina 27858,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lohman, Kurt" sort="Lohman, Kurt" uniqKey="Lohman K" first="Kurt" last="Lohman">Kurt Lohman</name><affiliation wicri:level="1"><nlm:aff id="a46"><institution>Internal Medicine Department, Wake Forest School of Medicine</institution>, Medical Center Boulevard, Winston-Salem, North Carolina 27157-1053,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Portas, Laura" sort="Portas, Laura" uniqKey="Portas L" first="Laura" last="Portas">Laura Portas</name><affiliation wicri:level="1"><nlm:aff id="a74"><institution>Institute of Population Genetics—CNR</institution>, Traversa La Crucca 3, 07040 Reg. Baldinca, Li Punti, Sassari,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name><affiliation wicri:level="1"><nlm:aff id="a119"><institution>Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Gateway Building</institution>, 3C309, 7201 Winsconsin Avenue, Bethesda, Maryland 20892-9205,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lyytik Inen, Leo Pekka" sort="Lyytik Inen, Leo Pekka" uniqKey="Lyytik Inen L" first="Leo-Pekka" last="Lyytik Inen">Leo-Pekka Lyytik Inen</name><affiliation wicri:level="1"><nlm:aff id="a120"><institution>Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere, School of Medicine</institution>, Tampere 33520,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yengo, Loic" sort="Yengo, Loic" uniqKey="Yengo L" first="Loic" last="Yengo">Loic Yengo</name><affiliation wicri:level="1"><nlm:aff id="a121"><institution>CNRS UMR 8199</institution>, 1 Rue du Professeur Calmette, Lille 59000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a122"><institution>Lille Pasteur Institute</institution>, 1 Rue du Professeur Calmette, Lille 59000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a123"><institution>Lille II University</institution>, 42 Rue paul Duez, Lille 59000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Franke, Lude" sort="Franke, Lude" uniqKey="Franke L" first="Lude" last="Franke">Lude Franke</name><affiliation wicri:level="1"><nlm:aff id="a115"><institution>Department of Genetics, University of Groningen, University Medical Centre Groningen</institution>, PO Box 72, Groningen 9700 AB,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation wicri:level="1"><nlm:aff id="a124"><institution>Clinical Research Branch, National Institute on Aging</institution>, 251 Bayview Blvd, Baltimore, Maryland 21250,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rose, Lynda M" sort="Rose, Lynda M" uniqKey="Rose L" first="Lynda M." last="Rose">Lynda M. Rose</name><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Preventive Medicine, Brigham and Women's Hospital</institution>, 900 Commonwealth Avenue East, Boston, Massachusetts 02215,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kedenko, Lyudmyla" sort="Kedenko, Lyudmyla" uniqKey="Kedenko L" first="Lyudmyla" last="Kedenko">Lyudmyla Kedenko</name><affiliation wicri:level="1"><nlm:aff id="a49"><institution>First Department of Internal Medicine, Paracelsus Medical University/Salzburger Landeskliniken</institution>, Müllner Hauptstraße 48, Salzburg 5020,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rao, Madhumathi" sort="Rao, Madhumathi" uniqKey="Rao M" first="Madhumathi" last="Rao">Madhumathi Rao</name><affiliation wicri:level="1"><nlm:aff id="a12"><institution>Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Tufts Medical Center</institution>, Boston, Massachusetts 02111,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Struchalin, Maksim" sort="Struchalin, Maksim" uniqKey="Struchalin M" first="Maksim" last="Struchalin">Maksim Struchalin</name><affiliation wicri:level="1"><nlm:aff id="a125"><institution>Department of Epidemiology and Biostatistics, Erasmus University Medical Center</institution>, Dr Molewaterplein, Rotterdam 50-603015 GE,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a126"><institution>Department of Forensic Molecular Biology, Erasmus University Medical Center</institution>, Dr Molewaterplein, Rotterdam 50-603015 GE,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kleber, Marcus E" sort="Kleber, Marcus E" uniqKey="Kleber M" first="Marcus E." last="Kleber">Marcus E. Kleber</name><affiliation wicri:level="1"><nlm:aff id="a127"><institution>Medical Clinic V, Medical Faculty Mannheim, Heidelberg University</institution>, Theodor-Kutzer-Ufer 1-3, Mannheim 68167,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cavalieri, Margherita" sort="Cavalieri, Margherita" uniqKey="Cavalieri M" first="Margherita" last="Cavalieri">Margherita Cavalieri</name><affiliation wicri:level="1"><nlm:aff id="a128"><institution>Austrian Stroke Prevention Study, Department of Neurology, Division of Special Neurology, Medical University Graz</institution>, Auenbruggerplatz 22, Graz 8036,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Haun, Margot" sort="Haun, Margot" uniqKey="Haun M" first="Margot" last="Haun">Margot Haun</name><affiliation wicri:level="1"><nlm:aff id="a45"><institution>Innsbruck Medical University, Division of Genetic Epidemiology</institution>, Schoepfstraße 41, Innsbruck 6020,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cornelis, Marilyn C" sort="Cornelis, Marilyn C" uniqKey="Cornelis M" first="Marilyn C." last="Cornelis">Marilyn C. Cornelis</name><affiliation wicri:level="1"><nlm:aff id="a75"><institution>Department of Nutrition, Harvard School of Public Health</institution>, 665 Huntington Avenue, Building 2, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ciullo, Marina" sort="Ciullo, Marina" uniqKey="Ciullo M" first="Marina" last="Ciullo">Marina Ciullo</name><affiliation wicri:level="1"><nlm:aff id="a10"><institution>Institute of Genetics and Biophysics "Adriano Buzzati-Traverso"—CNR</institution>, Via P. Castellino 111, Napoli 80131,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pirastu, Mario" sort="Pirastu, Mario" uniqKey="Pirastu M" first="Mario" last="Pirastu">Mario Pirastu</name><affiliation wicri:level="1"><nlm:aff id="a74"><institution>Institute of Population Genetics—CNR</institution>, Traversa La Crucca 3, 07040 Reg. Baldinca, Li Punti, Sassari,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De Andrade, Mariza" sort="De Andrade, Mariza" uniqKey="De Andrade M" first="Mariza" last="De Andrade">Mariza De Andrade</name><affiliation wicri:level="1"><nlm:aff id="a71"><institution>Division of Biomedical Statistics and Informatics, Mayo Clinic</institution>, 200 First Street SW, Rochester, Minnesota 55905,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mcevoy, Mark A" sort="Mcevoy, Mark A" uniqKey="Mcevoy M" first="Mark A." last="Mcevoy">Mark A. Mcevoy</name><affiliation wicri:level="1"><nlm:aff id="a129"><institution>Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Hunter Medical Research Institute, John Hunter Hospital</institution>, Locked Bag 1, HRMC, New South Wales 2310,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health</institution>, 615 North Wolfe Street, Baltimore, Maryland 21205,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a111"><institution>University of Sydney, The George Institute for Global Health</institution>, Level 10, King George V Building, 83-117 Missenden Road, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a112"><institution>Department of Medicine, University of Turku, Turku University Hospital</institution>, PO Box 52, Turku 20521,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a130"><institution>The George Institute for Global Health, Nuffield Department of Population Health, University of Oxford</institution>, Old Road Campus, Roosevelt Drive, Oxford OX3 7LF,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Adam, Martin" sort="Adam, Martin" uniqKey="Adam M" first="Martin" last="Adam">Martin Adam</name><affiliation wicri:level="1"><nlm:aff id="a79"><institution>Swiss Tropical and Public Health Institute</institution>, PO Box 4002, Basel,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a80"><institution>University of Basel</institution>, Petersplatz 1, Basel 4003,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cocca, Massimiliano" sort="Cocca, Massimiliano" uniqKey="Cocca M" first="Massimiliano" last="Cocca">Massimiliano Cocca</name><affiliation wicri:level="1"><nlm:aff id="a58"><institution>Division of Genetics and Cell Biology, San Raffaele Scientific Institute</institution>, Via Olgettina 58, Milano 20132,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nauck, Matthias" sort="Nauck, Matthias" uniqKey="Nauck M" first="Matthias" last="Nauck">Matthias Nauck</name><affiliation wicri:level="1"><nlm:aff id="a89"><institution>Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald</institution>, Ferdinand-Sauerbruch-Straße, Greifswald 17475,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a90"><institution>German Center for Cardiovascular Research (DZHK)</institution>, Partner site Greifswald, Ferdinand-Sauerbruch-Straße, Greifswald 17475,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Imboden, Medea" sort="Imboden, Medea" uniqKey="Imboden M" first="Medea" last="Imboden">Medea Imboden</name><affiliation wicri:level="1"><nlm:aff id="a79"><institution>Swiss Tropical and Public Health Institute</institution>, PO Box 4002, Basel,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a80"><institution>University of Basel</institution>, Petersplatz 1, Basel 4003,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Waldenberger, Melanie" sort="Waldenberger, Melanie" uniqKey="Waldenberger M" first="Melanie" last="Waldenberger">Melanie Waldenberger</name><affiliation wicri:level="1"><nlm:aff id="a67"><institution>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health</institution>, Ingolstaedter Landstraße 1, 85764 Neuherberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pruijm, Menno" sort="Pruijm, Menno" uniqKey="Pruijm M" first="Menno" last="Pruijm">Menno Pruijm</name><affiliation wicri:level="1"><nlm:aff id="a131"><institution>Service of Nephrology, Lausanne University Hospital</institution>, Rue du Bugnon 17, Lausanne 1005,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Metzger, Marie" sort="Metzger, Marie" uniqKey="Metzger M" first="Marie" last="Metzger">Marie Metzger</name><affiliation wicri:level="1"><nlm:aff id="a132"><institution>Inserm UMRS 1018, CESP Team 10, Université Paris-Sud</institution>, 16 avenue Paul Vaillant Couturier, Villejuif 94807,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stumvoll, Michael" sort="Stumvoll, Michael" uniqKey="Stumvoll M" first="Michael" last="Stumvoll">Michael Stumvoll</name><affiliation wicri:level="1"><nlm:aff id="a42"><institution>Department of Medicine, University of Leipzig</institution>, Liebigstraße 18, Leipzig 04103,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Evans, Michele K" sort="Evans, Michele K" uniqKey="Evans M" first="Michele K." last="Evans">Michele K. Evans</name><affiliation wicri:level="1"><nlm:aff id="a133"><institution>Health Disparities Research Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, NIH Biomedical Center</institution>, 251 Bayview Boulevard, Suite 100, Baltimore, Maryland 21224,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sale, Michele M" sort="Sale, Michele M" uniqKey="Sale M" first="Michele M." last="Sale">Michele M. Sale</name><affiliation wicri:level="1"><nlm:aff id="a134"><institution>Center for Public Health Genomics, Department of Medicine (Cardiovascular Medicine), University of Virginia</institution>, PO Box 800717, Charlottesville, Virginia 22908,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation wicri:level="1"><nlm:aff id="a135"><institution>Department of Clinical Physiology, Tampere University Hospital, University of Tampere, School of Medicine</institution>, Tampere 33521,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boban, Mladen" sort="Boban, Mladen" uniqKey="Boban M" first="Mladen" last="Boban">Mladen Boban</name><affiliation wicri:level="1"><nlm:aff id="a99"><institution>Croatian Centre for Global Health, University of Split Medical School</institution>, Šoltanska 2, Split 21000,<country>Croatia</country></nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bochud, Murielle" sort="Bochud, Murielle" uniqKey="Bochud M" first="Murielle" last="Bochud">Murielle Bochud</name><affiliation wicri:level="1"><nlm:aff id="a136"><institution>University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne</institution>, Route de la Corniche 2, Epalinges CH-1066,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rheinberger, Myriam" sort="Rheinberger, Myriam" uniqKey="Rheinberger M" first="Myriam" last="Rheinberger">Myriam Rheinberger</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Department of Nephrology, University Hospital Regensburg</institution>, Franz-Josef-Strauß-Allee 11, Regensburg 93053,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Verweij, Niek" sort="Verweij, Niek" uniqKey="Verweij N" first="Niek" last="Verweij">Niek Verweij</name><affiliation wicri:level="1"><nlm:aff id="a93"><institution>Department of Cardiology, University Medical Center Groningen, University of Groningen</institution>, PO Box 30.001, Groningen 9700 RB,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bouatia Naji, Nabila" sort="Bouatia Naji, Nabila" uniqKey="Bouatia Naji N" first="Nabila" last="Bouatia-Naji">Nabila Bouatia-Naji</name><affiliation wicri:level="1"><nlm:aff id="a137"><institution>INSERM UMR970, Paris Cardiovascular Research Center (PARCC)</institution>, 56 rue Leblanc, Paris F-75015,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a138"><institution>Paris Descartes University, Faculty of medicine, Paris Cité Sorbonne</institution>, 12 Rue de l'école de Médecine, Paris F-75006,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation wicri:level="1"><nlm:aff id="a82"><institution>Genetic Epidemiology, Queensland Institute of Medical Research, QIMR, PO Royal Brisbane Hospital</institution>, Queensland 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a139"><institution>Brigham and Women's Hospital, Harvard Medical School</institution>, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hastie, Nick" sort="Hastie, Nick" uniqKey="Hastie N" first="Nick" last="Hastie">Nick Hastie</name><affiliation wicri:level="1"><nlm:aff id="a31"><institution>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>, Crewe Road, Edinburgh EH4 2XU,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Probst Hensch, Nicole" sort="Probst Hensch, Nicole" uniqKey="Probst Hensch N" first="Nicole" last="Probst-Hensch">Nicole Probst-Hensch</name><affiliation wicri:level="1"><nlm:aff id="a79"><institution>Swiss Tropical and Public Health Institute</institution>, PO Box 4002, Basel,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a80"><institution>University of Basel</institution>, Petersplatz 1, Basel 4003,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation wicri:level="1"><nlm:aff id="a140"><institution>Wellcome Trust Sanger Institute</institution>, Hinxton CB10 1HH,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Devuyst, Olivier" sort="Devuyst, Olivier" uniqKey="Devuyst O" first="Olivier" last="Devuyst">Olivier Devuyst</name><affiliation wicri:level="1"><nlm:aff id="a141"><institution>University of Zurich, Institute of Physiology, Mechanisms of Inherited Kidney Disorders Group</institution>, Winterthurerstrasse 190, Zürich 8057,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><affiliation wicri:level="1"><nlm:aff id="a142"><institution>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku University Hospital, Department of Clinical Physiology</institution>, PO Box 52, Turku 20521,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gottesman, Omri" sort="Gottesman, Omri" uniqKey="Gottesman O" first="Omri" last="Gottesman">Omri Gottesman</name><affiliation wicri:level="1"><nlm:aff id="a61"><institution>The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai</institution>, New York, New York 10029,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H." last="Franco">Oscar H. Franco</name><affiliation wicri:level="1"><nlm:aff id="a24"><institution>Department of Epidemiology, Erasmus University Medical Center</institution>, PO Box 2040, Rotterdam 3000 CA,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name><affiliation wicri:level="1"><nlm:aff id="a99"><institution>Croatian Centre for Global Health, University of Split Medical School</institution>, Šoltanska 2, Split 21000,<country>Croatia</country></nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gasparini, Paolo" sort="Gasparini, Paolo" uniqKey="Gasparini P" first="Paolo" last="Gasparini">Paolo Gasparini</name><affiliation wicri:level="1"><nlm:aff id="a25"><institution>Institute for Maternal and Child Health—IRCCS "Burlo Garofolo" and University of Trieste</institution>, via dell'Istria 65/1, Trieste 34137,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Munroe, Patricia B" sort="Munroe, Patricia B" uniqKey="Munroe P" first="Patricia B." last="Munroe">Patricia B. Munroe</name><affiliation wicri:level="1"><nlm:aff id="a143"><institution>Department Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London</institution>, London EC1M 6BQ,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a144"><institution>NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London</institution>, London EC1M 6BQ,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M." last="Ridker">Paul M. Ridker</name><affiliation wicri:level="1"><nlm:aff id="a145"><institution>Harvard Medical School</institution>, 900 Commonwealth Avenue East, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name><affiliation wicri:level="1"><nlm:aff id="a108"><institution>Centre for Vision Research, Westmead Millennium Institute, University of Sydney</institution>, C24 Westmead Hospital, New South Wales 2145,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Muntner, Paul" sort="Muntner, Paul" uniqKey="Muntner P" first="Paul" last="Muntner">Paul Muntner</name><affiliation wicri:level="1"><nlm:aff id="a146"><institution>University of Alabama at Birmingham, Department of Medicine</institution>, 1530 3rd Avenue, South Birmingham, Alabama 35294-0022,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a147"><institution>University of Alabama at Birmingham, Department of Epidemiology</institution>, 1530 3rd Avenue, South Birmingham, Alabama 35294-0022,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Meisinger, Christa" sort="Meisinger, Christa" uniqKey="Meisinger C" first="Christa" last="Meisinger">Christa Meisinger</name><affiliation wicri:level="1"><nlm:aff id="a68"><institution>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health</institution>, 85764 Neuherberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Smit, Johannes H" sort="Smit, Johannes H" uniqKey="Smit J" first="Johannes H." last="Smit">Johannes H. Smit</name><affiliation wicri:level="1"><nlm:aff id="a148"><institution>Department of Psychiatry and EMGO+ Institute, VU University Medical Center</institution>, A.J. Ernststraat 1187, Amsterdam 1081 HL,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kovacs, Peter" sort="Kovacs, Peter" uniqKey="Kovacs P" first="Peter" last="Kovacs">Peter Kovacs</name><affiliation wicri:level="1"><nlm:aff id="a149"><institution>IFB AdiposityDiseases, University of Leipzig</institution>, Liebigstraße 21, Leipzig 04103,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wild, Philipp S" sort="Wild, Philipp S" uniqKey="Wild P" first="Philipp S." last="Wild">Philipp S. Wild</name><affiliation wicri:level="1"><nlm:aff id="a150"><institution>Medical University Center Mainz</institution>, Langenbeckstraße 1, Mainz 55131,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation wicri:level="1"><nlm:aff id="a121"><institution>CNRS UMR 8199</institution>, 1 Rue du Professeur Calmette, Lille 59000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a122"><institution>Lille Pasteur Institute</institution>, 1 Rue du Professeur Calmette, Lille 59000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a123"><institution>Lille II University</institution>, 42 Rue paul Duez, Lille 59000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rettig, Rainer" sort="Rettig, Rainer" uniqKey="Rettig R" first="Rainer" last="Rettig">Rainer Rettig</name><affiliation wicri:level="1"><nlm:aff id="a151"><institution>Institute of Physiology, University of Greifswald</institution>, Greifswald 17487,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name><affiliation wicri:level="1"><nlm:aff id="a40"><institution>Estonian Genome Center of University of Tartu (EGCUT)</institution>, Riia 23B, Tartu 51010,<country>Estonia</country></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Biffar, Reiner" sort="Biffar, Reiner" uniqKey="Biffar R" first="Reiner" last="Biffar">Reiner Biffar</name><affiliation wicri:level="1"><nlm:aff id="a152"><institution>Clinic for Prosthodontic Dentistry, Gerostomatology and Material Science, University of Greifswald</institution>, Rotgerberstraße 8, Greifswald 17475,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation wicri:level="1"><nlm:aff id="a128"><institution>Austrian Stroke Prevention Study, Department of Neurology, Division of Special Neurology, Medical University Graz</institution>, Auenbruggerplatz 22, Graz 8036,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Middelberg, Rita P S" sort="Middelberg, Rita P S" uniqKey="Middelberg R" first="Rita P. S." last="Middelberg">Rita P. S. Middelberg</name><affiliation wicri:level="1"><nlm:aff id="a82"><institution>Genetic Epidemiology, Queensland Institute of Medical Research, QIMR, PO Royal Brisbane Hospital</institution>, Queensland 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Carroll, Robert J" sort="Carroll, Robert J" uniqKey="Carroll R" first="Robert J." last="Carroll">Robert J. Carroll</name><affiliation wicri:level="1"><nlm:aff id="a114"><institution>Vanderbilt University School of Medicine</institution>, 448 Eskind Biomedical Library, 2209 Garland Avenue, Nashville, Tennessee 37212,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Penninx, Brenda W" sort="Penninx, Brenda W" uniqKey="Penninx B" first="Brenda W." last="Penninx">Brenda W. Penninx</name><affiliation wicri:level="1"><nlm:aff id="a148"><institution>Department of Psychiatry and EMGO+ Institute, VU University Medical Center</institution>, A.J. Ernststraat 1187, Amsterdam 1081 HL,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J." last="Scott">Rodney J. Scott</name><affiliation wicri:level="1"><nlm:aff id="a153"><institution>School of Biomedical Sciences and Pharmacy, University of Newcastle, Hunter Medical Research Institute, John Hunter Hospital</institution>, Locked Bag 1, HRMC, New South Wales 2310,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Katz, Ronit" sort="Katz, Ronit" uniqKey="Katz R" first="Ronit" last="Katz">Ronit Katz</name><affiliation wicri:level="1"><nlm:aff id="a154"><institution>Kidney Research Institute, University of Washington</institution>, Box 359606, 325 9th Avenue, Seattle, Washington 98104,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sedaghat, Sanaz" sort="Sedaghat, Sanaz" uniqKey="Sedaghat S" first="Sanaz" last="Sedaghat">Sanaz Sedaghat</name><affiliation wicri:level="1"><nlm:aff id="a24"><institution>Department of Epidemiology, Erasmus University Medical Center</institution>, PO Box 2040, Rotterdam 3000 CA,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H." last="Wild">Sarah H. Wild</name><affiliation wicri:level="1"><nlm:aff id="a87"><institution>Centre for Population Health Sciences, University of Edinburgh</institution>, Teviot Place, Edinburgh, EH8 9AG Scotland,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kardia, Sharon L R" sort="Kardia, Sharon L R" uniqKey="Kardia S" first="Sharon L. R." last="Kardia">Sharon L. R. Kardia</name><affiliation wicri:level="1"><nlm:aff id="a106"><institution>Department of Epidemiology, School of Public Health, University of Michigan</institution>, 1415 Washington Heights, Ann Arbor, Michigan 48109-2029,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ulivi, Sheila" sort="Ulivi, Sheila" uniqKey="Ulivi S" first="Sheila" last="Ulivi">Sheila Ulivi</name><affiliation wicri:level="1"><nlm:aff id="a155"><institution>Institute for Maternal and Child Health—IRCCS "Burlo Garofolo"</institution>, Via dell'Istria 65, Trieste 34137,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hwang, Shih Jen" sort="Hwang, Shih Jen" uniqKey="Hwang S" first="Shih-Jen" last="Hwang">Shih-Jen Hwang</name><affiliation wicri:level="1"><nlm:aff id="a17"><institution>NHLBI's Framingham Heart Study and the Center for Population Studies</institution>, 73 Mt Wayte Avenue, Suite 2, Framingham, Massachusetts 01702,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Enroth, Stefan" sort="Enroth, Stefan" uniqKey="Enroth S" first="Stefan" last="Enroth">Stefan Enroth</name><affiliation wicri:level="1"><nlm:aff id="a44"><institution>Uppsala University, Department of Immunology, Genetics and Pathology, Biomedical Center, SciLifeLab, Uppsala University</institution>, Uppsala SE- 75108,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kloiber, Stefan" sort="Kloiber, Stefan" uniqKey="Kloiber S" first="Stefan" last="Kloiber">Stefan Kloiber</name><affiliation wicri:level="1"><nlm:aff id="a63"><institution>Max Planck Institute of Psychiatry</institution>, Kraepelinstraße 2–10, Munich 80804,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name><affiliation wicri:level="1"><nlm:aff id="a100"><institution>Department of Cardiology, Leiden University Medical Center</institution>, PO Box 9600, Leiden 2300 RC,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stengel, Benedicte" sort="Stengel, Benedicte" uniqKey="Stengel B" first="Benedicte" last="Stengel">Benedicte Stengel</name><affiliation wicri:level="1"><nlm:aff id="a132"><institution>Inserm UMRS 1018, CESP Team 10, Université Paris-Sud</institution>, 16 avenue Paul Vaillant Couturier, Villejuif 94807,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hancock, Stephen J" sort="Hancock, Stephen J" uniqKey="Hancock S" first="Stephen J." last="Hancock">Stephen J. Hancock</name><affiliation wicri:level="1"><nlm:aff id="a72"><institution>Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, HMRI Building1, Kookaburra Circuit</institution>, New Lambton New South Wales 2305,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a73"><institution>Clinical Research Design, Information Technology and Statistical Support, Hunter Medical Research Institute, Newcastle</institution>, 1 Kookaburra Circuit, New Lambton Heights, New South Wales 2305,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Turner, Stephen T" sort="Turner, Stephen T" uniqKey="Turner S" first="Stephen T." last="Turner">Stephen T. Turner</name><affiliation wicri:level="1"><nlm:aff id="a156"><institution>Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic</institution>, 200 First Street SW, Rochester, Minnesota 55905,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rosas, Sylvia E" sort="Rosas, Sylvia E" uniqKey="Rosas S" first="Sylvia E." last="Rosas">Sylvia E. Rosas</name><affiliation wicri:level="1"><nlm:aff id="a18"><institution>Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania</institution>, 415 Curie Boulevard, 405B Clinical Research Building, Philadelphia, Pennsylvania 19104-4539,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stracke, Sylvia" sort="Stracke, Sylvia" uniqKey="Stracke S" first="Sylvia" last="Stracke">Sylvia Stracke</name><affiliation wicri:level="1"><nlm:aff id="a105"><institution>INSERM U744, Institut Pasteur de Lille</institution>, 1 rue du Pr, Calmette, Lille Cédex 59019,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a157"><institution>Clinic for Internal Medicine A, University of Greifswald</institution>, Friedrich-Loeffler-Straße 23a, Greifswald 17475,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation wicri:level="1"><nlm:aff id="a119"><institution>Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Gateway Building</institution>, 3C309, 7201 Winsconsin Avenue, Bethesda, Maryland 20892-9205,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zeller, Tanja" sort="Zeller, Tanja" uniqKey="Zeller T" first="Tanja" last="Zeller">Tanja Zeller</name><affiliation wicri:level="1"><nlm:aff id="a56"><institution>University Heart Center Hamburg, Clinic for general and interventional cardiology</institution>, Martinistraße 52, Hamburg 20246,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a57"><institution>German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Lübeck/Kiel</institution>, Martinistraße 52, Hamburg 20246, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>, Martinistraße 52, Hamburg 20246</wicri:regionArea><wicri:noRegion>20246</wicri:noRegion><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Zemunik, Tatijana" sort="Zemunik, Tatijana" uniqKey="Zemunik T" first="Tatijana" last="Zemunik">Tatijana Zemunik</name><affiliation wicri:level="1"><nlm:aff id="a99"><institution>Croatian Centre for Global Health, University of Split Medical School</institution>, Šoltanska 2, Split 21000,<country>Croatia</country></nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation wicri:level="1"><nlm:aff id="a120"><institution>Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere, School of Medicine</institution>, Tampere 33520,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name><affiliation wicri:level="1"><nlm:aff id="a68"><institution>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health</institution>, 85764 Neuherberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Aspelund, Thor" sort="Aspelund, Thor" uniqKey="Aspelund T" first="Thor" last="Aspelund">Thor Aspelund</name><affiliation wicri:level="1"><nlm:aff id="a35"><institution>Icelandic Heart Association, Research Institute</institution>, Holtasmari 1, Kopavogur 201,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a36"><institution>University of Iceland</institution>, Sæmundargötu 2, Reykjavik 101,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nikopensius, Tiit" sort="Nikopensius, Tiit" uniqKey="Nikopensius T" first="Tiit" last="Nikopensius">Tiit Nikopensius</name><affiliation wicri:level="1"><nlm:aff id="a40"><institution>Estonian Genome Center of University of Tartu (EGCUT)</institution>, Riia 23B, Tartu 51010,<country>Estonia</country></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a41"><institution>Institute of Molecular and Cell Biology, University of Tartu and Estonian Biocenter</institution>, Riia 23, Tartu 51010,<country>Estonia</country></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Esko, Tonu" sort="Esko, Tonu" uniqKey="Esko T" first="Tonu" last="Esko">Tonu Esko</name><affiliation wicri:level="1"><nlm:aff id="a15"><institution>Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital</institution>, 300 Longwood Avenue, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a40"><institution>Estonian Genome Center of University of Tartu (EGCUT)</institution>, Riia 23B, Tartu 51010,<country>Estonia</country></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a41"><institution>Institute of Molecular and Cell Biology, University of Tartu and Estonian Biocenter</institution>, Riia 23, Tartu 51010,<country>Estonia</country></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name><affiliation wicri:level="1"><nlm:aff id="a124"><institution>Clinical Research Branch, National Institute on Aging</institution>, 251 Bayview Blvd, Baltimore, Maryland 21250,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><affiliation wicri:level="1"><nlm:aff id="a44"><institution>Uppsala University, Department of Immunology, Genetics and Pathology, Biomedical Center, SciLifeLab, Uppsala University</institution>, Uppsala SE- 75108,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald</institution>, Friedrich-Loeffler-Straße 15a, Greifswald 17487,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a90"><institution>German Center for Cardiovascular Research (DZHK)</institution>, Partner site Greifswald, Ferdinand-Sauerbruch-Straße, Greifswald 17475,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Emilsson, Valur" sort="Emilsson, Valur" uniqKey="Emilsson V" first="Valur" last="Emilsson">Valur Emilsson</name><affiliation wicri:level="1"><nlm:aff id="a35"><institution>Icelandic Heart Association, Research Institute</institution>, Holtasmari 1, Kopavogur 201,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a158"><institution>Faculty of Pharmaceutical Sciences, University of Iceland</institution>, Sæmundargata 2, Reykjavik 101,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><affiliation wicri:level="1"><nlm:aff id="a31"><institution>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>, Crewe Road, Edinburgh EH4 2XU,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Aalto, Ville" sort="Aalto, Ville" uniqKey="Aalto V" first="Ville" last="Aalto">Ville Aalto</name><affiliation wicri:level="1"><nlm:aff id="a159"><institution>Department of Clinical Physiology, Turku University Hospital, Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku</institution>, PO Box 52, Turku 20521,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation wicri:level="1"><nlm:aff id="a35"><institution>Icelandic Heart Association, Research Institute</institution>, Holtasmari 1, Kopavogur 201,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a36"><institution>University of Iceland</institution>, Sæmundargötu 2, Reykjavik 101,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chouraki, Vincent" sort="Chouraki, Vincent" uniqKey="Chouraki V" first="Vincent" last="Chouraki">Vincent Chouraki</name><affiliation wicri:level="1"><nlm:aff id="a105"><institution>INSERM U744, Institut Pasteur de Lille</institution>, 1 rue du Pr, Calmette, Lille Cédex 59019,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Wei Min" sort="Chen, Wei Min" uniqKey="Chen W" first="Wei-Min" last="Chen">Wei-Min Chen</name><affiliation wicri:level="1"><nlm:aff id="a134"><institution>Center for Public Health Genomics, Department of Medicine (Cardiovascular Medicine), University of Virginia</institution>, PO Box 800717, Charlottesville, Virginia 22908,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Igl, Wilmar" sort="Igl, Wilmar" uniqKey="Igl W" first="Wilmar" last="Igl">Wilmar Igl</name><affiliation wicri:level="1"><nlm:aff id="a44"><institution>Uppsala University, Department of Immunology, Genetics and Pathology, Biomedical Center, SciLifeLab, Uppsala University</institution>, Uppsala SE- 75108,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="M Rz, Winfried" sort="M Rz, Winfried" uniqKey="M Rz W" first="Winfried" last="M Rz">Winfried M Rz</name><affiliation wicri:level="1"><nlm:aff id="a160"><institution>Synlab Academy, Synlab Services GmbH</institution>, Oberer Eselsberg 45, Ulm 89081,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name><affiliation wicri:level="1"><nlm:aff id="a161"><institution>Department of Internal Medicine II—Cardiology, University of Ulm Medical Centre</institution>, Albert-Einstein-Allee 23, Ulm 89081,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lieb, Wolfgang" sort="Lieb, Wolfgang" uniqKey="Lieb W" first="Wolfgang" last="Lieb">Wolfgang Lieb</name><affiliation wicri:level="1"><nlm:aff id="a83"><institution>Institute of Epidemiology and Biobank popgen, Christian-Albrechts University</institution>, Niemannsweg 11, Kiel 24105,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J. F." last="Loos">Ruth J. F. Loos</name><affiliation wicri:level="1"><nlm:aff id="a61"><institution>The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai</institution>, New York, New York 10029,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a162"><institution>The Mindich Child Health and Development Institute, Ichan School of Medicine at Mount Sinai</institution>, New York, New York 10029,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name><affiliation wicri:level="1"><nlm:aff id="a46"><institution>Internal Medicine Department, Wake Forest School of Medicine</institution>, Medical Center Boulevard, Winston-Salem, North Carolina 27157-1053,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Snieder, Harold" sort="Snieder, Harold" uniqKey="Snieder H" first="Harold" last="Snieder">Harold Snieder</name><affiliation wicri:level="1"><nlm:aff id="a30"><institution>Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen</institution>, PO Box 30001, Groningen 9700 RB,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck</institution>, Via Galvani 31, Bolzano 39100,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a163"><institution>Department of Neurology, General Central Hospital</institution>, Via Lorenz Bohler 5, Bolzano 39100,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a164"><institution>Department of Neurology, University of Lübeck</institution>, Ratzeburger Allee 160, Lübeck 23538,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Parsa, Afshin" sort="Parsa, Afshin" uniqKey="Parsa A" first="Afshin" last="Parsa">Afshin Parsa</name><affiliation wicri:level="1"><nlm:aff id="a165"><institution>University of Maryland Medical School, Division of Nephrology</institution>, 685 W. Baltimore Street, MSTF 314, Baltimore, Maryland 21201,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="O Connell, Jeffrey R" sort="O Connell, Jeffrey R" uniqKey="O Connell J" first="Jeffrey R." last="O'Connell">Jeffrey R. O'Connell</name><affiliation wicri:level="1"><nlm:aff id="a32"><institution>Department of Medicine, University of Maryland School of Medicine</institution>, 685 West Baltimore Street, Baltimore, Maryland 21201,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Susztak, Katalin" sort="Susztak, Katalin" uniqKey="Susztak K" first="Katalin" last="Susztak">Katalin Susztak</name><affiliation wicri:level="1"><nlm:aff id="a18"><institution>Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania</institution>, 415 Curie Boulevard, 405B Clinical Research Building, Philadelphia, Pennsylvania 19104-4539,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hamet, Pavel" sort="Hamet, Pavel" uniqKey="Hamet P" first="Pavel" last="Hamet">Pavel Hamet</name><affiliation wicri:level="1"><nlm:aff id="a166"><institution>CRCHUM, University of Montreal, CHUM Research Center, Technopôle Angus</institution>, 900 Saint-Denis, Montreal, Québec,<country>Canada</country> H2X 0A9</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tremblay, Johanne" sort="Tremblay, Johanne" uniqKey="Tremblay J" first="Johanne" last="Tremblay">Johanne Tremblay</name><affiliation wicri:level="1"><nlm:aff id="a166"><institution>CRCHUM, University of Montreal, CHUM Research Center, Technopôle Angus</institution>, 900 Saint-Denis, Montreal, Québec,<country>Canada</country> H2X 0A9</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De Boer, Ian H" sort="De Boer, Ian H" uniqKey="De Boer I" first="Ian H." last="De Boer">Ian H. De Boer</name><affiliation wicri:level="1"><nlm:aff id="a154"><institution>Kidney Research Institute, University of Washington</institution>, Box 359606, 325 9th Avenue, Seattle, Washington 98104,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boger, Carsten A" sort="Boger, Carsten A" uniqKey="Boger C" first="Carsten A." last="Böger">Carsten A. Böger</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Department of Nephrology, University Hospital Regensburg</institution>, Franz-Josef-Strauß-Allee 11, Regensburg 93053,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Goessling, Wolfram" sort="Goessling, Wolfram" uniqKey="Goessling W" first="Wolfram" last="Goessling">Wolfram Goessling</name><affiliation wicri:level="1"><nlm:aff id="a9"><institution>Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School</institution>, New Research Building77 Avenue Louis Pasteur, Room 458, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Preventive Medicine, Brigham and Women's Hospital</institution>, 900 Commonwealth Avenue East, Boston, Massachusetts 02215,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a145"><institution>Harvard Medical School</institution>, 900 Commonwealth Avenue East, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kottgen, Anna" sort="Kottgen, Anna" uniqKey="Kottgen A" first="Anna" last="Köttgen">Anna Köttgen</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health</institution>, 615 North Wolfe Street, Baltimore, Maryland 21205,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a11"><institution>Department of Internal Medicine IV, University Hospital Freiburg</institution>, Berliner Allee 29, Freiburg 79110,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kao, W H Linda" sort="Kao, W H Linda" uniqKey="Kao W" first="W. H. Linda" last="Kao">W. H. Linda Kao</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health</institution>, 615 North Wolfe Street, Baltimore, Maryland 21205,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a113"><institution>Welch Center for Prevention, Epidemiology and Clinical Research</institution>, 2024 East Monument St, Suite 2-600, Baltimore, Maryland 21287,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fox, Caroline S" sort="Fox, Caroline S" uniqKey="Fox C" first="Caroline S." last="Fox">Caroline S. Fox</name><affiliation wicri:level="1"><nlm:aff id="a17"><institution>NHLBI's Framingham Heart Study and the Center for Population Studies</institution>, 73 Mt Wayte Avenue, Suite 2, Framingham, Massachusetts 01702,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a167"><institution>Division of Endocrinology, Brigham and Women s Hospital, Harvard Medical School</institution>, 221 Longwood Avenue, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Nature Communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. 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rid="a158">158</xref></contrib><contrib contrib-type="author"><name><surname>Vitart</surname><given-names>Veronique</given-names></name><xref ref-type="aff" rid="a31">31</xref></contrib><contrib contrib-type="author"><name><surname>Aalto</surname><given-names>Ville</given-names></name><xref ref-type="aff" rid="a159">159</xref></contrib><contrib contrib-type="author"><name><surname>Gudnason</surname><given-names>Vilmundur</given-names></name><xref ref-type="aff" rid="a35">35</xref><xref ref-type="aff" rid="a36">36</xref></contrib><contrib contrib-type="author"><name><surname>Chouraki</surname><given-names>Vincent</given-names></name><xref ref-type="aff" rid="a105">105</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Wei-Min</given-names></name><xref ref-type="aff" rid="a134">134</xref></contrib><contrib contrib-type="author"><name><surname>Igl</surname><given-names>Wilmar</given-names></name><xref ref-type="aff" rid="a44">44</xref></contrib><contrib contrib-type="author"><name><surname>März</surname><given-names>Winfried</given-names></name><xref ref-type="aff" rid="a160">160</xref></contrib><contrib contrib-type="author"><name><surname>Koenig</surname><given-names>Wolfgang</given-names></name><xref ref-type="aff" rid="a161">161</xref></contrib><contrib contrib-type="author"><name><surname>Lieb</surname><given-names>Wolfgang</given-names></name><xref ref-type="aff" rid="a83">83</xref></contrib><contrib contrib-type="author"><name><surname>Loos</surname><given-names>Ruth J. F.</given-names></name><xref ref-type="aff" rid="a61">61</xref><xref ref-type="aff" rid="a162">162</xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Yongmei</given-names></name><xref ref-type="aff" rid="a46">46</xref></contrib><contrib contrib-type="author"><name><surname>Snieder</surname><given-names>Harold</given-names></name><xref ref-type="aff" rid="a30">30</xref></contrib><contrib contrib-type="author"><name><surname>Pramstaller</surname><given-names>Peter P.</given-names></name><xref ref-type="aff" rid="a1">1</xref><xref ref-type="aff" rid="a163">163</xref><xref ref-type="aff" rid="a164">164</xref></contrib><contrib contrib-type="author"><name><surname>Parsa</surname><given-names>Afshin</given-names></name><xref ref-type="aff" rid="a165">165</xref></contrib><contrib contrib-type="author"><name><surname>O'Connell</surname><given-names>Jeffrey R.</given-names></name><xref ref-type="aff" rid="a32">32</xref></contrib><contrib contrib-type="author"><name><surname>Susztak</surname><given-names>Katalin</given-names></name><xref ref-type="aff" rid="a18">18</xref></contrib><contrib contrib-type="author"><name><surname>Hamet</surname><given-names>Pavel</given-names></name><xref ref-type="aff" rid="a166">166</xref></contrib><contrib contrib-type="author"><name><surname>Tremblay</surname><given-names>Johanne</given-names></name><xref ref-type="aff" rid="a166">166</xref></contrib><contrib contrib-type="author"><name><surname>de Boer</surname><given-names>Ian H.</given-names></name><xref ref-type="aff" rid="a154">154</xref></contrib><contrib contrib-type="author"><name><surname>Böger</surname><given-names>Carsten A.</given-names></name><xref ref-type="aff" rid="a5">5</xref><xref ref-type="author-notes" rid="n2">†</xref></contrib><contrib contrib-type="author"><name><surname>Goessling</surname><given-names>Wolfram</given-names></name><xref ref-type="aff" rid="a9">9</xref><xref ref-type="author-notes" rid="n2">†</xref><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0001-9972-1569</contrib-id></contrib><contrib contrib-type="author"><name><surname>Chasman</surname><given-names>Daniel I.</given-names></name><xref ref-type="aff" rid="a6">6</xref><xref ref-type="aff" rid="a145">145</xref><xref ref-type="author-notes" rid="n2">†</xref></contrib><contrib contrib-type="author"><name><surname>Köttgen</surname><given-names>Anna</given-names></name><xref ref-type="corresp" rid="c2">b</xref><xref ref-type="aff" rid="a7">7</xref><xref ref-type="aff" rid="a11">11</xref><xref ref-type="author-notes" rid="n2">†</xref></contrib><contrib contrib-type="author"><name><surname>Kao</surname><given-names>W. H. Linda</given-names></name><xref ref-type="aff" rid="a7">7</xref><xref ref-type="aff" rid="a113">113</xref><xref ref-type="author-notes" rid="n2">†</xref><xref ref-type="author-notes" rid="n4">§</xref></contrib><contrib contrib-type="author"><name><surname>Fox</surname><given-names>Caroline S.</given-names></name><xref ref-type="corresp" rid="c3">c</xref><xref ref-type="aff" rid="a17">17</xref><xref ref-type="aff" rid="a167">167</xref><xref ref-type="author-notes" rid="n2">†</xref></contrib><aff id="a1"><label>1</label><institution>Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck</institution>, Via Galvani 31, Bolzano 39100,<country>Italy</country></aff><aff id="a2"><label>2</label><institution>Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald</institution>, Friedrich-Loeffler-Straße 15a, Greifswald 17487,<country>Germany</country></aff><aff id="a3"><label>3</label><institution>Institute for Community Medicine, University of Greifswald</institution>, Walther-Rathenau-Strasse 48, Greifswald 17487,<country>Germany</country></aff><aff id="a4"><label>4</label><institution>Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg</institution>, Franz-Josef-Strauß-Allee 11, Regensburg 93053,<country>Germany</country></aff><aff id="a5"><label>5</label><institution>Department of Nephrology, University Hospital Regensburg</institution>, Franz-Josef-Strauß-Allee 11, Regensburg 93053,<country>Germany</country></aff><aff id="a6"><label>6</label><institution>Preventive Medicine, Brigham and Women's Hospital</institution>, 900 Commonwealth Avenue East, Boston, Massachusetts 02215,<country>USA</country></aff><aff id="a7"><label>7</label><institution>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health</institution>, 615 North Wolfe Street, Baltimore, Maryland 21205,<country>USA</country></aff><aff id="a8"><label>8</label><institution>Department of Life and Reproduction Sciences, University of Verona</institution>, Strada Le Grazie 8, Verona 37134,<country>Italy</country></aff><aff id="a9"><label>9</label><institution>Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School</institution>, New Research Building77 Avenue Louis Pasteur, Room 458, Boston, Massachusetts 02115,<country>USA</country></aff><aff id="a10"><label>10</label><institution>Institute of Genetics and Biophysics "Adriano Buzzati-Traverso"—CNR</institution>, Via P. Castellino 111, Napoli 80131,<country>Italy</country></aff><aff id="a11"><label>11</label><institution>Department of Internal Medicine IV, University Hospital Freiburg</institution>, Berliner Allee 29, Freiburg 79110,<country>Germany</country></aff><aff id="a12"><label>12</label><institution>Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Tufts Medical Center</institution>, Boston, Massachusetts 02111,<country>USA</country></aff><aff id="a13"><label>13</label><institution>Department of Biostatistics, Boston University School of Public Health</institution>, 715 Albany Street, Boston, Massachusetts 02118,<country>USA</country></aff><aff id="a14"><label>14</label><institution>Department of Neurology, Boston University School of Medicine</institution>, 72 East Concord ST B603, Boston, Massachusetts 02118,<country>USA</country></aff><aff id="a15"><label>15</label><institution>Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital</institution>, 300 Longwood Avenue, Boston, Massachusetts 02115,<country>USA</country></aff><aff id="a16"><label>16</label><institution>Medical and Population Genetics Program, Broad Institute of MIT and Harvard</institution>, Cambridge, Massachusetts 2142,<country>USA</country></aff><aff id="a17"><label>17</label><institution>NHLBI's Framingham Heart Study and the Center for Population Studies</institution>, 73 Mt Wayte Avenue, Suite 2, Framingham, Massachusetts 01702,<country>USA</country></aff><aff id="a18"><label>18</label><institution>Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania</institution>, 415 Curie Boulevard, 405B Clinical Research Building, Philadelphia, Pennsylvania 19104-4539,<country>USA</country></aff><aff id="a19"><label>19</label><institution>Department of Public Health Sciences, Loyola Medical Center</institution>, 2160 S First Avenue, Maywood, Illinois 60153,<country>USA</country></aff><aff id="a20"><label>20</label><institution>Laboratory of Neurogenetics</institution>, Building 35—Porter Building, 1A1015, National Institute on Aging/NIH, Bethesda, Maryland 20892,<country>USA</country></aff><aff id="a21"><label>21</label><institution>Division of Statistical Genomics, Washington University School of Medicine</institution>, 4444 Forest Park Boulevard, Box 8506, St Louis, Missouri 63108,<country>USA</country></aff><aff id="a22"><label>22</label><institution>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center</institution>, Dr Molewaterplein 50, PO Box 2040, Rotterdam 3000 CA,<country>The Netherlands</country></aff><aff id="a23"><label>23</label><institution>Centre for Medical Systems Biology Leiden</institution>, Dr Molewaterplein 50, PO Box 2040, Rotterdam 3000 CA,<country>The Netherlands</country></aff><aff id="a24"><label>24</label><institution>Department of Epidemiology, Erasmus University Medical Center</institution>, PO Box 2040, Rotterdam 3000 CA,<country>The Netherlands</country></aff><aff id="a25"><label>25</label><institution>Institute for Maternal and Child Health—IRCCS "Burlo Garofolo" and University of Trieste</institution>, via dell'Istria 65/1, Trieste 34137,<country>Italy</country></aff><aff id="a26"><label>26</label><institution>Center for Research on Genomics and Global Health, National Human Genome Research Institute</institution>, Building 12A, Room 4047, 12 South Dr, MSC 5635, Bethesda, Maryland 20892-5635,<country>USA</country></aff><aff id="a27"><label>27</label><institution>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)</institution>, Im Neuenheimer Feld 581, Heidelberg 69120,<country>Germany</country></aff><aff id="a28"><label>28</label><institution>German Cancer Consortium (DKTK)</institution>, Im Neuenheimer Feld 581, Heidelberg 69120,<country>Germany</country></aff><aff id="a29"><label>29</label><institution>Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, NIH Biomedical Center</institution>, 251 Bayview Boulevard, Suite 100, Baltimore, Maryland 21224,<country>USA</country></aff><aff id="a30"><label>30</label><institution>Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen</institution>, PO Box 30001, Groningen 9700 RB,<country>The Netherlands</country></aff><aff id="a31"><label>31</label><institution>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>, Crewe Road, Edinburgh EH4 2XU,<country>UK</country></aff><aff id="a32"><label>32</label><institution>Department of Medicine, University of Maryland School of Medicine</institution>, 685 West Baltimore Street, Baltimore, Maryland 21201,<country>USA</country></aff><aff id="a33"><label>33</label><institution>Geriatric Research and Education Clinical Center, Veterans Administration Medical Center</institution>, 10 North Greene Street, Baltimore, Maryland 21201,<country>USA</country></aff><aff id="a34"><label>34</label><institution>Human Genetics Center, University of Texas Health Science Center at Houston</institution>, 1200 Pressler St Suite 453E, Houston, Texas 77030,<country>USA</country></aff><aff id="a35"><label>35</label><institution>Icelandic Heart Association, Research Institute</institution>, Holtasmari 1, Kopavogur 201,<country>Iceland</country></aff><aff id="a36"><label>36</label><institution>University of Iceland</institution>, Sæmundargötu 2, Reykjavik 101,<country>Iceland</country></aff><aff id="a37"><label>37</label><institution>Division of Nephrology, University of Mississippi</institution>, 2500 North State Street, Jackson, Mississippi 39216,<country>USA</country></aff><aff id="a38"><label>38</label><institution>Institute of Clinical Molecular Biology, Christian-Albrechts University of Kiel</institution>, Schittenhelmstraße 12, Kiel 24105,<country>Germany</country></aff><aff id="a39"><label>39</label><institution>Department of Internal Medicine, Erasmus University Medical Center</institution>, PO Box 1738, Rotterdam 3000 DR,<country>The Netherlands</country></aff><aff id="a40"><label>40</label><institution>Estonian Genome Center of University of Tartu (EGCUT)</institution>, Riia 23B, Tartu 51010,<country>Estonia</country></aff><aff id="a41"><label>41</label><institution>Institute of Molecular and Cell Biology, University of Tartu and Estonian Biocenter</institution>, Riia 23, Tartu 51010,<country>Estonia</country></aff><aff id="a42"><label>42</label><institution>Department of Medicine, University of Leipzig</institution>, Liebigstraße 18, Leipzig 04103,<country>Germany</country></aff><aff id="a43"><label>43</label><institution>Division of Nephrology, Department of Medicine, University of Verona</institution>, Piazzale Aristide Stefani 1, Verona 37126,<country>Italy</country></aff><aff id="a44"><label>44</label><institution>Uppsala University, Department of Immunology, Genetics and Pathology, Biomedical Center, SciLifeLab, Uppsala University</institution>, Uppsala SE- 75108,<country>Sweden</country></aff><aff id="a45"><label>45</label><institution>Innsbruck Medical University, Division of Genetic Epidemiology</institution>, Schoepfstraße 41, Innsbruck 6020,<country>Austria</country></aff><aff id="a46"><label>46</label><institution>Internal Medicine Department, Wake Forest School of Medicine</institution>, Medical Center Boulevard, Winston-Salem, North Carolina 27157-1053,<country>USA</country></aff><aff id="a47"><label>47</label><institution>Nephrology Division, Department of Specialties of Internal Medicine, Geneva University Hospital</institution>, 4 rue Gabrielle-Perret-Gentil, Geneve 1211,<country>Switzerland</country></aff><aff id="a48"><label>48</label><institution>Department of Clinical Genetics, Erasmus University Medical Center</institution>, Dr Molewaterplein 50, PO Box 2040, Rotterdam 3000 CA,<country>The Netherlands</country></aff><aff id="a49"><label>49</label><institution>First Department of Internal Medicine, Paracelsus Medical University/Salzburger Landeskliniken</institution>, Müllner Hauptstraße 48, Salzburg 5020,<country>Austria</country></aff><aff id="a50"><label>50</label><institution>University Medical Centre Mannheim, 5th Department of Medicine, University of Heidelberg</institution>, Theodor Kutzer Ufer 1-3, Mannheim 68167,<country>Germany</country></aff><aff id="a51"><label>51</label><institution>Department of Pharmacology and Therapeutics, University College Cork, Clinical Investigations Building</institution>, Western Rd, Cork,<country>Ireland</country></aff><aff id="a52"><label>52</label><institution>Division of Nephrology, University of California, San Francisco Medical School and San Francisco VA Medical Center</institution>, 4150 Clement Street, San Francisco, California 94121,<country>USA</country></aff><aff id="a53"><label>53</label><institution>INSERM, ISPED, Centre INSERM U897—Epidemiologie-Biostatistique</institution>, Bordeaux F-33000,<country>France</country></aff><aff id="a54"><label>54</label><institution>Université Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique</institution>, Bordeaux F-33000,<country>France</country></aff><aff id="a55"><label>55</label><institution>Vanderbilt University School of Medicine</institution>, 2215-B Garland Avenue 1224—MRB4 (Light Hall)Nashville, Tennessee 37232,<country>USA</country></aff><aff id="a56"><label>56</label><institution>University Heart Center Hamburg, Clinic for general and interventional cardiology</institution>, Martinistraße 52, Hamburg 20246,<country>Germany</country></aff><aff id="a57"><label>57</label><institution>German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Lübeck/Kiel</institution>, Martinistraße 52, Hamburg 20246, Germany</aff><aff id="a58"><label>58</label><institution>Division of Genetics and Cell Biology, San Raffaele Scientific Institute</institution>, Via Olgettina 58, Milano 20132,<country>Italy</country></aff><aff id="a59"><label>59</label><institution>INSERM U1078, Etablissement Français du Sang</institution>, 46 rue Félix Le Dantec, CS 51819, Brest Cedex 2 29218,<country>France</country></aff><aff id="a60"><label>60</label><institution>Institute of Molecular Genetics-CNR</institution>, Via Abbiategrasso 207, Pavia 27100,<country>Italy</country></aff><aff id="a61"><label>61</label><institution>The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai</institution>, New York, New York 10029,<country>USA</country></aff><aff id="a62"><label>62</label><institution>Department of Health Sciences, University of Milano</institution>, Via Antonio di Rudinì 8, Milano 20142,<country>Italy</country></aff><aff id="a63"><label>63</label><institution>Max Planck Institute of Psychiatry</institution>, Kraepelinstraße 2–10, Munich 80804,<country>Germany</country></aff><aff id="a64"><label>64</label><institution>Cardiovascular Health Research Unit, Departments of Epidemiology and Medicine, University of Washington</institution>, 1730 Minor Ave, Suite 1360, Seattle, Washington 98101,<country>USA</country></aff><aff id="a65"><label>65</label><institution>Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai</institution>, New York, New York 10029,<country>USA</country></aff><aff id="a66"><label>66</label><institution>Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health</institution>, Ingolstaedter Landstraße 1, 85764 Neuherberg,<country>Germany</country></aff><aff id="a67"><label>67</label><institution>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health</institution>, Ingolstaedter Landstraße 1, 85764 Neuherberg,<country>Germany</country></aff><aff id="a68"><label>68</label><institution>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health</institution>, 85764 Neuherberg,<country>Germany</country></aff><aff id="a69"><label>69</label><institution>German Center for Diabetes Research (DZD)</institution>, Ingolstaedter Landstraße 1, Neuherberg 85764,<country>Germany</country></aff><aff id="a70"><label>70</label><institution>Westmead Millennium Institute, Centre for Vision Research, University of Sydney</institution>, C24 Westmead Hospital, New South Wales 2145,<country>Australia</country></aff><aff id="a71"><label>71</label><institution>Division of Biomedical Statistics and Informatics, Mayo Clinic</institution>, 200 First Street SW, Rochester, Minnesota 55905,<country>USA</country></aff><aff id="a72"><label>72</label><institution>Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, HMRI Building1, Kookaburra Circuit</institution>, New Lambton New South Wales 2305,<country>Australia</country></aff><aff id="a73"><label>73</label><institution>Clinical Research Design, Information Technology and Statistical Support, Hunter Medical Research Institute, Newcastle</institution>, 1 Kookaburra Circuit, New Lambton Heights, New South Wales 2305,<country>Australia</country></aff><aff id="a74"><label>74</label><institution>Institute of Population Genetics—CNR</institution>, Traversa La Crucca 3, 07040 Reg. Baldinca, Li Punti, Sassari,<country>Italy</country></aff><aff id="a75"><label>75</label><institution>Department of Nutrition, Harvard School of Public Health</institution>, 665 Huntington Avenue, Building 2, Boston, Massachusetts 02115,<country>USA</country></aff><aff id="a76"><label>76</label><institution>Department of Internal Medicine, University Medical Center Groningen, University of Groningen</institution>, Hanzeplein 1, Groningen 9713 GZ,<country>The Netherlands</country></aff><aff id="a77"><label>77</label><institution>Brigham and Women's Hospital and Channing Laboratory, Harvard Medical School</institution>, 181 Longwood Avenue, Boston, Massachusetts 02115,<country>USA</country></aff><aff id="a78"><label>78</label><institution>Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospitals</institution>, Rue Gabrielle-Perret-Gentil 4, Geneva 1205,<country>Switzerland</country></aff><aff id="a79"><label>79</label><institution>Swiss Tropical and Public Health Institute</institution>, PO Box 4002, Basel,<country>Switzerland</country></aff><aff id="a80"><label>80</label><institution>University of Basel</institution>, Petersplatz 1, Basel 4003,<country>Switzerland</country></aff><aff id="a81"><label>81</label><institution>Division of Nephrology, Department of Internal Medicine and Medical Specialties, Columbus-Gemelli University Hospital, Catholic University</institution>, Via Moscati 31, Rome 00168,<country>Italy</country></aff><aff id="a82"><label>82</label><institution>Genetic Epidemiology, Queensland Institute of Medical Research, QIMR, PO Royal Brisbane Hospital</institution>, Queensland 4029,<country>Australia</country></aff><aff id="a83"><label>83</label><institution>Institute of Epidemiology and Biobank popgen, Christian-Albrechts University</institution>, Niemannsweg 11, Kiel 24105,<country>Germany</country></aff><aff id="a84"><label>84</label><institution>Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health</institution>, Ingolstädter Landstraße 1, Neuherberg 85764,<country>Germany</country></aff><aff id="a85"><label>85</label><institution>Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Ingolstädter Landstrasse 1</institution>, 85764 Neuherberg,<country>Germany</country></aff><aff id="a86"><label>86</label><institution>Klinikum Grosshadern</institution>, Ingolstädter Landstraße 1, Neuherberg 85764,<country>Germany</country></aff><aff id="a87"><label>87</label><institution>Centre for Population Health Sciences, University of Edinburgh</institution>, Teviot Place, Edinburgh, EH8 9AG Scotland,<country>UK</country></aff><aff id="a88"><label>88</label><institution>Austrian Stroke Prevention Study, Institute of Molecular Biology and Biochemistry, Department of Neurology, Medical University Graz</institution>, Harrachgasse 21, Graz 8010,<country>Austria</country></aff><aff id="a89"><label>89</label><institution>Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald</institution>, Ferdinand-Sauerbruch-Straße, Greifswald 17475,<country>Germany</country></aff><aff id="a90"><label>90</label><institution>German Center for Cardiovascular Research (DZHK)</institution>, Partner site Greifswald, Ferdinand-Sauerbruch-Straße, Greifswald 17475,<country>Germany</country></aff><aff id="a91"><label>91</label><institution>Institute of Pharmacology, University of Greifswald</institution>, Friedrich-Loeffler-Straße 23d, Greifswald 17487,<country>Germany</country></aff><aff id="a92"><label>92</label><institution>Boston University School of Medicine</institution>, 72 East Concord Street, B-616, Boston, Massachusetts 02118,<country>USA</country></aff><aff id="a93"><label>93</label><institution>Department of Cardiology, University Medical Center Groningen, University of Groningen</institution>, PO Box 30.001, Groningen 9700 RB,<country>The Netherlands</country></aff><aff id="a94"><label>94</label><institution>Robertson Centre for Biostatistics, University of Glasgow</institution>, R1122B Level 11, Robertson Centre, Boyd Orr Building, Glasgow G12 8QQ,<country>UK</country></aff><aff id="a95"><label>95</label><institution>Division of Primary Care Medicine, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals, Faculty of Medicine, University of Geneva</institution>, Geneva 1211,<country>Switzerland</country></aff><aff id="a96"><label>96</label><institution>Community Prevention Unit, University Institute of Social and Preventive Medicine, Lausanne University Hospital</institution>, Route de la Corniche 10, Lausanne 1010,<country>Switzerland</country></aff><aff id="a97"><label>97</label><institution>Department of Epidemiology, Rollins School of Public Health, Emory University</institution>, 1518 Clifton Road, NE, Atlanta, Georgia 30322,<country>USA</country></aff><aff id="a98"><label>98</label><institution>Department of Genomics of Common Disease, School of Public Health, Imperial College London</institution>, London W12 0NN,<country>UK</country></aff><aff id="a99"><label>99</label><institution>Croatian Centre for Global Health, University of Split Medical School</institution>, Šoltanska 2, Split 21000,<country>Croatia</country></aff><aff id="a100"><label>100</label><institution>Department of Cardiology, Leiden University Medical Center</institution>, PO Box 9600, Leiden 2300 RC,<country>The Netherlands</country></aff><aff id="a101"><label>101</label><institution>Interuniversity Cardiology Institute of the Netherlands (ICIN)</institution>, Moreelsepark 1, Utrecht 3511 EP,<country>The Netherlands</country></aff><aff id="a102"><label>102</label><institution>Einthoven Laboratory for Experimental Vascular Medicine</institution>, Albinusdreef 2, Leiden 2333 ZA,<country>The Netherlands</country></aff><aff id="a103"><label>103</label><institution>Durrer Center for Cardiogenetic Research</institution>, Meibergdreef 9, Amsterdam 1105 AZ,<country>The Netherlands</country></aff><aff id="a104"><label>104</label><institution>Division of Public Health Sciences, Department of Biostatistical Sciences, Wake Forest University Health Sciences</institution>, 2326 Medical Center Boulevard, Winston-Salem, North Carolina 27157-1063,<country>USA</country></aff><aff id="a105"><label>105</label><institution>INSERM U744, Institut Pasteur de Lille</institution>, 1 rue du Pr, Calmette, Lille Cédex 59019,<country>France</country></aff><aff id="a106"><label>106</label><institution>Department of Epidemiology, School of Public Health, University of Michigan</institution>, 1415 Washington Heights, Ann Arbor, Michigan 48109-2029,<country>USA</country></aff><aff id="a107"><label>107</label><institution>Survey Research Center, Institute for Social Research, University of Michigan</institution>, 426 Thompson Street, #3456, Ann Arbor, Michigan 48104,<country>USA</country></aff><aff id="a108"><label>108</label><institution>Centre for Vision Research, Westmead Millennium Institute, University of Sydney</institution>, C24 Westmead Hospital, New South Wales 2145,<country>Australia</country></aff><aff id="a109"><label>109</label><institution>Wake Forest School of Medicine, Department of Internal Medicine/Geriatrics</institution>, Medical center Boulevard, Winston-Salem, North Carolina 27157,<country>USA</country></aff><aff id="a110"><label>110</label><institution>Department of Genetics, Harvard Medical School</institution>, 77 Avenue Louis Pasteur, NRB 0330, Boston, Massachusetts 02115,<country>USA</country></aff><aff id="a111"><label>111</label><institution>University of Sydney, The George Institute for Global Health</institution>, Level 10, King George V Building, 83-117 Missenden Road, Camperdown, New South Wales 2050,<country>Australia</country></aff><aff id="a112"><label>112</label><institution>Department of Medicine, University of Turku, Turku University Hospital</institution>, PO Box 52, Turku 20521,<country>Finland</country></aff><aff id="a113"><label>113</label><institution>Welch Center for Prevention, Epidemiology and Clinical Research</institution>, 2024 East Monument St, Suite 2-600, Baltimore, Maryland 21287,<country>USA</country></aff><aff id="a114"><label>114</label><institution>Vanderbilt University School of Medicine</institution>, 448 Eskind Biomedical Library, 2209 Garland Avenue, Nashville, Tennessee 37212,<country>USA</country></aff><aff id="a115"><label>115</label><institution>Department of Genetics, University of Groningen, University Medical Centre Groningen</institution>, PO Box 72, Groningen 9700 AB,<country>The Netherlands</country></aff><aff id="a116"><label>116</label><institution>Division of Endocrinology, Medical University of South Carolina</institution>, 171 Ashley Avenue, Charleston, South Carolina 29425,<country>USA</country></aff><aff id="a117"><label>117</label><institution>Institute of Anatomy and Cell Biology, University of Greifswald</institution>, Friedrich-Loeffler-Straße 23c, Greifswald 17487,<country>Germany</country></aff><aff id="a118"><label>118</label><institution>Center for Health Disparities, Department of Biology, East Carolina University</institution>, 1001 East 10th Street, N209 Howell Science Complex Mailstop 551, Greenville, North Carolina 27858,<country>USA</country></aff><aff id="a119"><label>119</label><institution>Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Gateway Building</institution>, 3C309, 7201 Winsconsin Avenue, Bethesda, Maryland 20892-9205,<country>USA</country></aff><aff id="a120"><label>120</label><institution>Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere, School of Medicine</institution>, Tampere 33520,<country>Finland</country></aff><aff id="a121"><label>121</label><institution>CNRS UMR 8199</institution>, 1 Rue du Professeur Calmette, Lille 59000,<country>France</country></aff><aff id="a122"><label>122</label><institution>Lille Pasteur Institute</institution>, 1 Rue du Professeur Calmette, Lille 59000,<country>France</country></aff><aff id="a123"><label>123</label><institution>Lille II University</institution>, 42 Rue paul Duez, Lille 59000,<country>France</country></aff><aff id="a124"><label>124</label><institution>Clinical Research Branch, National Institute on Aging</institution>, 251 Bayview Blvd, Baltimore, Maryland 21250,<country>USA</country></aff><aff id="a125"><label>125</label><institution>Department of Epidemiology and Biostatistics, Erasmus University Medical Center</institution>, Dr Molewaterplein, Rotterdam 50-603015 GE,<country>The Netherlands</country></aff><aff id="a126"><label>126</label><institution>Department of Forensic Molecular Biology, Erasmus University Medical Center</institution>, Dr Molewaterplein, Rotterdam 50-603015 GE,<country>The Netherlands</country></aff><aff id="a127"><label>127</label><institution>Medical Clinic V, Medical Faculty Mannheim, Heidelberg University</institution>, Theodor-Kutzer-Ufer 1-3, Mannheim 68167,<country>Germany</country></aff><aff id="a128"><label>128</label><institution>Austrian Stroke Prevention Study, Department of Neurology, Division of Special Neurology, Medical University Graz</institution>, Auenbruggerplatz 22, Graz 8036,<country>Austria</country></aff><aff id="a129"><label>129</label><institution>Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Hunter Medical Research Institute, John Hunter Hospital</institution>, Locked Bag 1, HRMC, New South Wales 2310,<country>Australia</country></aff><aff id="a130"><label>130</label><institution>The George Institute for Global Health, Nuffield Department of Population Health, University of Oxford</institution>, Old Road Campus, Roosevelt Drive, Oxford OX3 7LF,<country>UK</country></aff><aff id="a131"><label>131</label><institution>Service of Nephrology, Lausanne University Hospital</institution>, Rue du Bugnon 17, Lausanne 1005,<country>Switzerland</country></aff><aff id="a132"><label>132</label><institution>Inserm UMRS 1018, CESP Team 10, Université Paris-Sud</institution>, 16 avenue Paul Vaillant Couturier, Villejuif 94807,<country>France</country></aff><aff id="a133"><label>133</label><institution>Health Disparities Research Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, NIH Biomedical Center</institution>, 251 Bayview Boulevard, Suite 100, Baltimore, Maryland 21224,<country>USA</country></aff><aff id="a134"><label>134</label><institution>Center for Public Health Genomics, Department of Medicine (Cardiovascular Medicine), University of Virginia</institution>, PO Box 800717, Charlottesville, Virginia 22908,<country>USA</country></aff><aff id="a135"><label>135</label><institution>Department of Clinical Physiology, Tampere University Hospital, University of Tampere, School of Medicine</institution>, Tampere 33521,<country>Finland</country></aff><aff id="a136"><label>136</label><institution>University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne</institution>, Route de la Corniche 2, Epalinges CH-1066,<country>Switzerland</country></aff><aff id="a137"><label>137</label><institution>INSERM UMR970, Paris Cardiovascular Research Center (PARCC)</institution>, 56 rue Leblanc, Paris F-75015,<country>France</country></aff><aff id="a138"><label>138</label><institution>Paris Descartes University, Faculty of medicine, Paris Cité Sorbonne</institution>, 12 Rue de l'école de Médecine, Paris F-75006,<country>France</country></aff><aff id="a139"><label>139</label><institution>Brigham and Women's Hospital, Harvard Medical School</institution>, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115,<country>USA</country></aff><aff id="a140"><label>140</label><institution>Wellcome Trust Sanger Institute</institution>, Hinxton CB10 1HH,<country>UK</country></aff><aff id="a141"><label>141</label><institution>University of Zurich, Institute of Physiology, Mechanisms of Inherited Kidney Disorders Group</institution>, Winterthurerstrasse 190, Zürich 8057,<country>Switzerland</country></aff><aff id="a142"><label>142</label><institution>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku University Hospital, Department of Clinical Physiology</institution>, PO Box 52, Turku 20521,<country>Finland</country></aff><aff id="a143"><label>143</label><institution>Department Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London</institution>, London EC1M 6BQ,<country>UK</country></aff><aff id="a144"><label>144</label><institution>NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London</institution>, London EC1M 6BQ,<country>UK</country></aff><aff id="a145"><label>145</label><institution>Harvard Medical School</institution>, 900 Commonwealth Avenue East, Boston, Massachusetts 02115,<country>USA</country></aff><aff id="a146"><label>146</label><institution>University of Alabama at Birmingham, Department of Medicine</institution>, 1530 3rd Avenue, South Birmingham, Alabama 35294-0022,<country>USA</country></aff><aff id="a147"><label>147</label><institution>University of Alabama at Birmingham, Department of Epidemiology</institution>, 1530 3rd Avenue, South Birmingham, Alabama 35294-0022,<country>USA</country></aff><aff id="a148"><label>148</label><institution>Department of Psychiatry and EMGO+ Institute, VU University Medical Center</institution>, A.J. Ernststraat 1187, Amsterdam 1081 HL,<country>The Netherlands</country></aff><aff id="a149"><label>149</label><institution>IFB AdiposityDiseases, University of Leipzig</institution>, Liebigstraße 21, Leipzig 04103,<country>Germany</country></aff><aff id="a150"><label>150</label><institution>Medical University Center Mainz</institution>, Langenbeckstraße 1, Mainz 55131,<country>Germany</country></aff><aff id="a151"><label>151</label><institution>Institute of Physiology, University of Greifswald</institution>, Greifswald 17487,<country>Germany</country></aff><aff id="a152"><label>152</label><institution>Clinic for Prosthodontic Dentistry, Gerostomatology and Material Science, University of Greifswald</institution>, Rotgerberstraße 8, Greifswald 17475,<country>Germany</country></aff><aff id="a153"><label>153</label><institution>School of Biomedical Sciences and Pharmacy, University of Newcastle, Hunter Medical Research Institute, John Hunter Hospital</institution>, Locked Bag 1, HRMC, New South Wales 2310,<country>Australia</country></aff><aff id="a154"><label>154</label><institution>Kidney Research Institute, University of Washington</institution>, Box 359606, 325 9th Avenue, Seattle, Washington 98104,<country>USA</country></aff><aff id="a155"><label>155</label><institution>Institute for Maternal and Child Health—IRCCS "Burlo Garofolo"</institution>, Via dell'Istria 65, Trieste 34137,<country>Italy</country></aff><aff id="a156"><label>156</label><institution>Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic</institution>, 200 First Street SW, Rochester, Minnesota 55905,<country>USA</country></aff><aff id="a157"><label>157</label><institution>Clinic for Internal Medicine A, University of Greifswald</institution>, Friedrich-Loeffler-Straße 23a, Greifswald 17475,<country>Germany</country></aff><aff id="a158"><label>158</label><institution>Faculty of Pharmaceutical Sciences, University of Iceland</institution>, Sæmundargata 2, Reykjavik 101,<country>Iceland</country></aff><aff id="a159"><label>159</label><institution>Department of Clinical Physiology, Turku University Hospital, Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku</institution>, PO Box 52, Turku 20521,<country>Finland</country></aff><aff id="a160"><label>160</label><institution>Synlab Academy, Synlab Services GmbH</institution>, Oberer Eselsberg 45, Ulm 89081,<country>Germany</country></aff><aff id="a161"><label>161</label><institution>Department of Internal Medicine II—Cardiology, University of Ulm Medical Centre</institution>, Albert-Einstein-Allee 23, Ulm 89081,<country>Germany</country></aff><aff id="a162"><label>162</label><institution>The Mindich Child Health and Development Institute, Ichan School of Medicine at Mount Sinai</institution>, New York, New York 10029,<country>USA</country></aff><aff id="a163"><label>163</label><institution>Department of Neurology, General Central Hospital</institution>, Via Lorenz Bohler 5, Bolzano 39100,<country>Italy</country></aff><aff id="a164"><label>164</label><institution>Department of Neurology, University of Lübeck</institution>, Ratzeburger Allee 160, Lübeck 23538,<country>Germany</country></aff><aff id="a165"><label>165</label><institution>University of Maryland Medical School, Division of Nephrology</institution>, 685 W. Baltimore Street, MSTF 314, Baltimore, Maryland 21201,<country>USA</country></aff><aff id="a166"><label>166</label><institution>CRCHUM, University of Montreal, CHUM Research Center, Technopôle Angus</institution>, 900 Saint-Denis, Montreal, Québec,<country>Canada</country> H2X 0A9</aff><aff id="a167"><label>167</label><institution>Division of Endocrinology, Brigham and Women s Hospital, Harvard Medical School</institution>, 221 Longwood Avenue, Boston, Massachusetts 02115,<country>USA</country></aff><aff id="a168"><label>168</label><institution>Center for Statistical Genetics, Department of Biostatistics, University of Michigan, School of Public Health</institution>, Ann Arbor, Michigan 48103,<country>USA</country></aff><aff id="a169"><label>169</label><institution>Department of Nutrition, University of North Carolina</institution>, Chapel Hill, North Carolina 27599,<country>USA</country></aff><aff id="a170"><label>170</label><institution>Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge, CB1 8RN,<country>UK</country></aff><aff id="a171"><label>171</label><institution>Department of Medicine, Harvard Medical School</institution>, Boston, Massachusetts 02115,<country>USA</country></aff><aff id="a172"><label>172</label><institution>Department of Genetics, Harvard Medical School</institution>, Boston, Massachusetts 02115,<country>USA</country></aff><aff id="a173"><label>173</label><institution>Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine</institution>, Baltimore, Maryland 21205,<country>USA</country></aff><aff id="a174"><label>174</label><institution>Center for Human Genetic Research, Cardiovascular Research Center, Massachusetts General Hospital</institution>, Boston, Massachusetts 02114,<country>USA</country></aff><aff id="a175"><label>175</label><institution>Geriatric Rehabilitation Unit, Azienda Sanitaria Firenze (ASF)</institution>, 50125 Florence,<country>Italy</country></aff><aff id="a176"><label>176</label><institution>Département de Génétique Médicale, Université de Lausanne</institution>, Lausanne 1015,<country>Switzerland</country></aff><aff id="a177"><label>177</label><institution>Pathology and Laboratory Medicine, University of Western Australia</institution>, 6009 Crawley, Western Australia,<country>Australia</country></aff><aff id="a178"><label>178</label><institution>Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California</institution>, Los Angeles, California 90033,<country>USA</country></aff><aff id="a179"><label>179</label><institution>Cardiovascular Health Research Unit, Department of Medicine, University of Washington</institution>, Seattle 98195, Washington,<country>USA</country></aff><aff id="a180"><label>180</label><institution>National Human Genome Research Institute, National Institutes of Health</institution>, Bethesda, Maryland 20892,<country>USA</country></aff><aff id="a181"><label>181</label><institution>Department of Medicine III, Medical Faculty Carl Gustav Carus at the Technical University of Dresden</institution>, Dresden 01307,<country>Germany</country></aff><aff id="a182"><label>182</label><institution>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht</institution>, Heidelberglaan 100, Utrecht 3508 GA,<country>The Netherlands</country></aff><aff id="a183"><label>183</label><institution>Leibniz-Institute for Arteriosclerosis Research, Department of Molecular Genetics of Cardiovascular Disease, University of Münster</institution>, Münster,<country>Germany</country></aff><aff id="a184"><label>184</label><institution>University Hospital Münster, Internal Medicine D</institution>, Münster,<country>Germany</country></aff><aff id="a185"><label>185</label><institution>Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital</institution>, Leicester LE3 9QP,<country>UK</country></aff><aff id="a186"><label>186</label><institution>Clinical Pharmacology Unit, University of Cambridge, Addenbrookes Hospital</institution>, Hills Road, Cambridge CB2 2QQ,<country>UK</country></aff><aff id="a187"><label>187</label><institution>Department of Health Sciences, University of Leicester</institution>, University Rd, Leicester LE1 7RH,<country>UK</country></aff><aff id="a188"><label>188</label><institution>Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine</institution>, London WC1E 7HT,<country>UK</country></aff><aff id="a189"><label>189</label><institution>Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London</institution>, London EC1M 6BQ,<country>UK</country></aff><aff id="a190"><label>190</label><institution>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</institution>, Norfolk Place, London W2 1PG,<country>UK</country></aff><aff id="a191"><label>191</label><institution>Centre for Cellular and Molecular Biology (CCMB), Council of Scientific and Industrial Research (CSIR)</institution>, Uppal Road, Hyderabad 500 007,<country>India</country></aff><aff id="a192"><label>192</label><institution>University of Maryland, School of Medicine</institution>, Baltimore, Maryland 21201,<country>USA</country></aff><aff id="a193"><label>193</label><institution>School of Science and Engineering, University of Ballarat</institution>, Ballarat 3353,<country>Australia</country></aff><aff id="a194"><label>194</label><institution>International Centre for Circulatory Health, National Heart & Lung Institute, Imperial College</institution>, London,<country>UK</country></aff><aff id="a195"><label>195</label><institution>Center for Genome Science, National Institute of Health</institution>, Seoul,<country>Korea</country></aff><aff id="a196"><label>196</label><institution>Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford</institution>, Oxford OX3 7LF,<country>UK</country></aff><aff id="a197"><label>197</label><institution>University of Dundee, Ninewells Hospital & Medical School</institution>, Dundee DD1 9SY,<country>UK</country></aff><aff id="a198"><label>198</label><institution>Centre for Cardiovascular Genetics, University College London</institution>, London WC1E 6JF,<country>UK</country></aff><aff id="a199"><label>199</label><institution>Centre for Genetic Epidemiology and Biostatistics, University of Western Australia</institution>, Crawley, Western Australia,<country>Australia</country></aff><aff id="a200"><label>200</label><institution>Department of Preventive Medicine and Epidemiology, Loyola University Medical School</institution>, Maywood, Illinois,<country>USA</country></aff><aff id="a201"><label>201</label><institution>Tuscany Regional Health Agency</institution>, Florence,<country>Italy</country></aff><aff id="a202"><label>202</label><institution>Department of Internal Medicine B, Ernst-Moritz-Arndt-University Greifswald</institution>, Greifswald 17487,<country>Germany</country></aff><aff id="a203"><label>203</label><institution>Occupational and Environmental Medicine, Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg</institution>, Gothenburg 40530,<country>Sweden</country></aff><aff id="a204"><label>204</label><institution>MRC Centre for Causal Analyses in Translational Epidemiology, School of Social & Community Medicine, University of Bristol</institution>, Bristol BS8 2BN,<country>UK</country></aff><aff id="a205"><label>205</label><institution>BHF Glasgow Cardiovascular Research Centre, University of Glasgow</institution>, 126 University Place, Glasgow G12 8TA,<country>UK</country></aff><aff id="a206"><label>206</label><institution>Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia</institution>, 30912 Augusta, Georgia,<country>USA</country></aff><aff id="a207"><label>207</label><institution>Cardiovascular Epidemiology and Genetics, Institut Municipal d'Investigacio Medica, Barcelona Biomedical Research Park</institution>, 88 Doctor Aiguader, Barcelona 08003,<country>Spain</country></aff><aff id="a208"><label>208</label><institution>Medizinische Klinik II, Universität zu Lübeck</institution>, 23562 Lübeck,<country>Germany</country></aff><aff id="a209"><label>209</label><institution>Department of Statistics, Pontificia Universidad Catolica de Chile, Vicun˜a Mackena</institution>, Santiago 4860,<country>Chile</country></aff><aff id="a210"><label>210</label><institution>Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford</institution>, Oxford OX3 7BN,<country>UK</country></aff><aff id="a211"><label>211</label><institution>Department of Clinical Sciences, Lund University</institution>, SE-205 02 Malmö,<country>Sweden</country></aff><aff id="a212"><label>212</label><institution>Tropical Medicine Research Institute, University of the West Indies</institution>, Mona, Kingston,<country>Jamaica</country></aff><aff id="a213"><label>213</label><institution>Department of Medicine, University of Mississippi Medical Center</institution>, 2500 North State St, Jackson, Mississippi 39216,<country>USA</country></aff><aff id="a214"><label>214</label><institution>Genetics of Complex Traits, Peninsula Medical School, University of Exeter</institution>, EX1 2LU Exeter,<country>UK</country></aff><aff id="a215"><label>215</label><institution>U557 Institut National de la Santé et de la Recherche Médicale, U1125 Institut National de la Recherche Agronomique, Université Paris 13</institution>, F-93017 Bobigny,<country>France</country></aff><aff id="a216"><label>216</label><institution>Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan Medical Center</institution>, Ann Arbor 48108, Michigan,<country>USA</country></aff><aff id="a217"><label>217</label><institution>Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health</institution>, Bethesda, Maryland 20892,<country>USA</country></aff><aff id="a218"><label>218</label><institution>Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital</institution>, SE-205 02 Malmö,<country>Sweden</country></aff><aff id="a219"><label>219</label><institution>Human Genetics Foundation (HUGEF)</institution>, Via Lagrange 35, Torino 10123,<country>Italy</country></aff><aff id="a220"><label>220</label><institution>Medical Genetics Institute, Cedars-Sinai Medical Center</institution>, Los Angeles, 90048 California,<country>USA</country></aff><aff id="a221"><label>221</label><institution>Division of Community Health Sciences, St George's University of London</institution>, London SW17 0RE,<country>UK</country></aff><aff id="a222"><label>222</label><institution>Atherosclerosis Research Unit, Department of Medicine, Karolinska Institute</institution>, SE-171 77 Stockholm, Sweden</aff><aff id="a223"><label>223</label><institution>MRC Unit for Lifelong Health & Ageing</institution>, London WC1B 5JU,<country>UK</country></aff><aff id="a224"><label>224</label><institution>Institute of Clinical Medicine/Obstetrics and Gynecology, University of Oulu</institution>, 90014 Oulu,<country>Finland</country></aff><aff id="a225"><label>225</label><institution>Centre National de Génotypage, Commissariat de L'Energie Atomique, Institut de Génomique</institution>, 91000 Evry,<country>France</country></aff><aff id="a226"><label>226</label><institution>Department of Epidemiology, University of Washington, Seattle</institution>, Washington 98195,<country>USA</country></aff><aff id="a227"><label>227</label><institution>Epidemiology Public Health, UCL</institution>, London WC1E 6BT,<country>UK</country></aff><aff id="a228"><label>228</label><institution>William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London</institution>, London EC1M 6BQ,<country>UK</country></aff><aff id="a229"><label>229</label><institution>Cardiovascular Genetics, University of Utah, School of Medicine</institution>, Salt Lake City, 84132 Utah,<country>USA</country></aff><aff id="a230"><label>230</label><institution>HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology</institution>, Levanger 7600,<country>Norway</country></aff><aff id="a231"><label>231</label><institution>Department of Community Health Sciences, Aga Khan University</institution>, 74800 Karachi,<country>Pakistan</country></aff><aff id="a232"><label>232</label><institution>Department of Medicine, Aga Khan University</institution>, 74800 Karachi,<country>Pakistan</country></aff><aff id="a233"><label>233</label><institution>Department of Genomic Medicine, National Cerebral and Cardiovascular Research Center</institution>, Suita 565-8565,<country>Japan</country></aff><aff id="a234"><label>234</label><institution>Department of Preventive Cardiology, National Cerebral and Cardiovascular Research Center</institution>, Suita 565-8565,<country>Japan</country></aff><aff id="a235"><label>235</label><institution>Medical Population Genetics, Broad Institute of Harvard and MIT, 5 Cambridge Center</institution>, Cambridge, Massachusetts 02142,<country>USA</country></aff><aff id="a236"><label>236</label><institution>Division of Non-communicable disease Epidemiology, The London School of Hygiene and Tropical Medicine London</institution>, Keppel Street, London WC1E 7HT,<country>UK</country></aff><aff id="a237"><label>237</label><institution>Department of Health Science, Shiga University of Medical Science</institution>, Otsu 520-2192,<country>Japan</country></aff><aff id="a238"><label>238</label><institution>National Heart and Lung Institute, Imperial College London</institution>, London W12 0HS,<country>UK</country></aff><aff id="a239"><label>239</label><institution>Diabetes Unit, KEM Hospital and Research Centre, Rasta Peth</institution>, Pune, 411011 Maharashtra,<country>India</country></aff><aff id="a240"><label>240</label><institution>Genetic Epidemiology Group, Epidemiology and Public Health, UCL</institution>, London WC1E 6BT,<country>UK</country></aff><aff id="a241"><label>241</label><institution>Department of Medicine, University of Kuopio, Kuopio University Hospital</institution>, Kuopio 70210,<country>Finland</country></aff><aff id="a242"><label>242</label><institution>Studies Coordinating Centre, Division of Hypertension and Cardiac Rehabilitation, Department of Cardiovascular Diseases, University of Leuven</institution>, Campus Sint Rafaël, Kapucijnenvoer 35, Block D, Box 7001, Leuven 3000,<country>Belgium</country></aff><aff id="a243"><label>243</label><institution>Institute of Molecular and Cell Biology, University of Tartu</institution>, Riia 23, Tartu 51010,<country>Estonia</country></aff><aff id="a244"><label>244</label><institution>Finnish Institute of Occupational Health, Finnish Institute of Occupational Health</institution>, Aapistie 1, Oulu 90220,<country>Finland</country></aff><aff id="a245"><label>245</label><institution>Gerontology Research Center, National Institute on Aging</institution>, Baltimore, Maryland 21224,<country>USA</country></aff><aff id="a246"><label>246</label><institution>Wake Forest University Health Sciences</institution>, Winston-Salem, North Carolina 27157,<country>USA</country></aff><aff id="a247"><label>247</label><institution>National Heart, Lung and Blood Institute Framingham Heart Study</institution>, Framingham, 01702-5827 Massachusetts,<country>USA</country></aff><aff id="a248"><label>248</label><institution>Office of Population Studies Foundation, University of San Carlos</institution>, Talamban, Cebu 6000,<country>Philippines</country></aff><aff id="a249"><label>249</label><institution>Department of Epidemiology and Biostatistics, Case Western Reserve University</institution>, 2103 Cornell Road, Cleveland, Ohio 44106,<country>USA</country></aff><aff id="a250"><label>250</label><institution>Department of Medicine and Neurology, University ofWashington</institution>, Seattle, Washington 98195,<country>USA</country></aff><aff id="a251"><label>251</label><institution>MRC Epidemiology Unit, Institute of Metabolic Science</institution>, Cambridge CB2 0QQ,<country>UK</country></aff><aff id="a252"><label>252</label><institution>Department of Twin Research and Genetic Epidemiology, King's College London</institution>, SE1 7EH London,<country>UK</country></aff><aff id="a253"><label>253</label><institution>Department of Genetics, Biology and Biochemistry, University of Torino</institution>, Via Santena 19, Torino 10126,<country>Italy</country></aff><aff id="a254"><label>254</label><institution>ALSPAC Laboratory, University of Bristol</institution>, Bristol BS8 2BN,<country>UK</country></aff><aff id="a255"><label>255</label><institution>Institute of Human Genetics, Helmholtz Zentrum Munich, German Research Centre for Environmental Health</institution>, Neuherberg 85764,<country>Germany</country></aff><aff id="a256"><label>256</label><institution>U872 Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers</institution>, 75006 Paris,<country>France</country></aff><aff id="a257"><label>257</label><institution>Mayo Clinic</institution>, Jacksonville, 32224 Florida,<country>USA</country></aff><aff id="a258"><label>258</label><institution>Department of Basic Medical Research and Education, Ehime University Graduate School of Medicine</institution>, Toon 791-0295,<country>Japan</country></aff><aff id="a259"><label>259</label><institution>Department of Geriatric Medicine, Ehime University Graduate School of Medicine</institution>, Toon 791-0295,<country>Japan</country></aff><aff id="a260"><label>260</label><institution>Department of Genetics, University of North Carolina</institution>, Chapel Hill, North Carolina 27599,<country>USA</country></aff><aff id="a261"><label>261</label><institution>Division of Genetics, GlaxoSmithKline</institution>, Philadelphia, Pennsylvania 19101,<country>USA</country></aff><aff id="a262"><label>262</label><institution>Department of Primary Care and Population Health, UCL</institution>, London NW3 2PF,<country>UK</country></aff><aff id="a263"><label>263</label><institution>Department of Medicine (Geriatrics), University of Mississippi Medical Center</institution>, Jackson, 39216 Mississippi,<country>USA</country></aff><aff id="a264"><label>264</label><institution>Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH</institution>, Baltimore, 21224-6825 Maryland,<country>USA</country></aff><aff id="a265"><label>265</label><institution>Department of Geriatric Medicine, Osaka University Graduate School of Medicine</institution>, Suita 565-0871,<country>Japan</country></aff><aff id="a266"><label>266</label><institution>Tohoku University, Graduate School of Pharmaceutical Sciences and Medicine</institution>, Sendai 980-8578,<country>Japan</country></aff><aff id="a267"><label>267</label><institution>Genome Institute of Singapore, Agency for Science, Technology and Research</institution>, Singapore 138672,<country>Singapore</country></aff><aff id="a268"><label>268</label><institution>Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato</institution>, 09042 Monserrato, Cagliari, Italy</aff><aff id="a269"><label>269</label><institution>Columbia University</institution>, New York, 10027 New York,<country>USA</country></aff><aff id="a270"><label>270</label><institution>Amgen</institution>, 1 Kendall Square, Building 100, Cambridge, Massachusetts 02139,<country>USA</country></aff><aff id="a271"><label>271</label><institution>National Institute for Health and Welfare</institution>, Helsinki 00271,<country>Finland</country></aff><aff id="a272"><label>272</label><institution>Merck Research Laboratory</institution>, 126 East Lincoln Avenue, Rahway, New Jersey 07065,<country>USA</country></aff><aff id="a273"><label>273</label><institution>South Asia Network for Chronic Disease, Public Health Foundation of India</institution>, C-1/52, SDA, New Delhi 100016,<country>India</country></aff><aff id="a274"><label>274</label><institution>Division of Biostatistics, Washington University School of Medicine</institution>, Saint Louis, Missouri 63110,<country>USA</country></aff><aff id="a275"><label>275</label><institution>Center for Non-Communicable Diseases</institution>, 74800 Karachi,<country>Pakistan</country></aff><aff id="a276"><label>276</label><institution>Department of Biostatistics, University of Washington</institution>, Seattle, 98105 Washington,<country>USA</country></aff><aff id="a277"><label>277</label><institution>Department of Emergency and Cardiovascular Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg</institution>, Gothenburg 41685,<country>Sweden</country></aff><aff id="a278"><label>278</label><institution>Epidemiology & Prevention, Division of Public Health Sciences, Wake Forest University, School of Medicine</institution>, Winston-Salem, North Carolina 27157,<country>USA</country></aff><aff id="a279"><label>279</label><institution>University of Ibadan</institution>, PMB 5017 Ibadan,<country>Nigeria</country></aff><aff id="a280"><label>280</label><institution>Prevention and Care of Diabetes, Department of Medicine III, Medical Faculty Carl Gustav Carus at the Technical University of Dresden</institution>, Dresden 01307,<country>Germany</country></aff><aff id="a281"><label>281</label><institution>Department of Laboratory Medicine, Institute of Human Genetics, University of California, San Francisco</institution>, 513 Parnassus Avenue, San Francisco, California 94143,<country>USA</country></aff><aff id="a282"><label>282</label><institution>Imperial College Cerebrovascular Unit (ICCRU), Imperial College</institution>, London W6 8RF,<country>UK</country></aff><aff id="a283"><label>283</label><institution>Centre for Molecular Epidemiology, Yong Loo Lin School of Medicine, National University of Singapore</institution>, Singapore 117597,<country>Singapore</country></aff><aff id="a284"><label>284</label><institution>Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore</institution>, Singapore 119074,<country>Singapore</country></aff><aff id="a285"><label>285</label><institution>Faculty of Medicine, University of Split</institution>, 21000 Split,<country>Croatia</country></aff><aff id="a286"><label>286</label><institution>Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo</institution>, Oslo 0317,<country>Norway</country></aff><aff id="a287"><label>287</label><institution>Diabetes Prevention Unit, National Institute for Health and Welfare</institution>, Helsinki 00271,<country>Finland</country></aff><aff id="a288"><label>288</label><institution>Lifestyle-related Disease Prevention Center, Shiga University of Medical Science</institution>, Otsu 520-2192,<country>Japan</country></aff><aff id="a289"><label>289</label><institution>Department of Medical Science and Cardiorenal Medicine, Yokohama City University School of Medicine</institution>, Yokohama 236-0004,<country>Japan</country></aff><aff id="a290"><label>290</label><institution>Tallinn University of Technology, Institute of Biomedical Engineering</institution>, Ehitajate tee 5, Tallinn 19086,<country>Estonia</country></aff><aff id="a291"><label>291</label><institution>Department of Epidemiology and Public Health, Imperial College, Norfolk Place</institution>, London W2 1PG,<country>UK</country></aff><aff id="a292"><label>292</label><institution>Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois</institution>, Lausanne 1011,<country>Switzerland</country></aff><aff id="a293"><label>293</label><institution>Department of Medicine, Johns Hopkins University</institution>, Baltimore, 21205 Maryland,<country>USA</country></aff><aff id="a294"><label>294</label><institution>Lapland Central Hospital, Department of Physiatrics</institution>, Box 8041, Rovaniemi 96101,<country>Finland</country></aff><aff id="a295"><label>295</label><institution>Department of Internal Medicine, Diabetology, and Nephrology, Medical University of Silesia</institution></aff><aff id="a296"><label>296</label><institution>Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></aff><aff id="a297"><label>297</label><institution>Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University</institution>, Tokyo 113-8510,<country>Japan</country></aff><aff id="a298"><label>298</label><institution>Institute of Biomedical Sciences, Academia Sinica</institution>, Taipei 115,<country>Taiwan</country></aff><aff id="a299"><label>299</label><institution>School of Chinese Medicine, China Medical University</institution>, Taichung 404,<country>Taiwan</country></aff><aff id="a300"><label>300</label><institution>Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College</institution>, Beijing 100037,<country>China</country></aff><aff id="a301"><label>301</label><institution>Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine</institution>, Tokyo 162-8655,<country>Japan</country></aff><aff id="a302"><label>302</label><institution>Laboratory for Endocrinology and Metabolism, RIKEN Center for Integrative Medical Sciences</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></aff><aff id="a303"><label>303</label><institution>Laboratory for Medical Informatics, RIKEN Center for Integrative Medical Sciences</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></aff><aff id="a304"><label>304</label><institution>Saw Swee Hock School of Public Health, National University of Singapore</institution>, Singapore 119077,<country>Singapore</country></aff><aff id="a305"><label>305</label><institution>Department of Medicine, Khoo Teck Puat Hospital</institution>, Singapore 768828,<country>Singapore</country></aff><aff id="a306"><label>306</label><institution>Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore</institution>, Singapore 117597,<country>Singapore</country></aff><aff id="a307"><label>307</label><institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>, Singapore 168751,<country>Singapore</country></aff><aff id="a308"><label>308</label><institution>Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</institution>, Singapore 117597,<country>Singapore</country></aff><aff id="a309"><label>309</label><institution>Centre for Eye Research Australia, University of Melbourne</institution>, East Melbourne, 3002 Victoria,<country>Australia</country></aff><aff id="a310"><label>310</label><institution>Center for Human Genetics, Duke University Medical Center</institution>, Durham, 27710 North Carolina,<country>USA</country></aff><aff id="a311"><label>311</label><institution>Department of Statistics and Applied Probability, National University of Singapore</institution>, Singapore 117546,<country>Singapore</country></aff><aff id="a312"><label>312</label><institution>NUS Graduate School for Integrative Science and Engineering, National University of Singapore</institution>, Singapore 119077,<country>Singapore</country></aff><aff id="a313"><label>313</label><institution>Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex</institution>, 187 Chungcheongbuk-do,<country>Korea</country></aff><aff id="a314"><label>314</label><institution>Department of Preventive Medicine, Seoul National University College of Medicine</institution>, Seoul 08826,<country>Korea</country></aff><aff id="a315"><label>315</label><institution>Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine</institution>, New Orleans, 70112 Louisiana,<country>USA</country></aff><aff id="a316"><label>316</label><institution>Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine</institution>, Suita, Osaka 565-0871,<country>Japan</country></aff><aff id="a317"><label>317</label><institution>Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine</institution>, Suita, Osaka 565-0871,<country>Japan</country></aff><aff id="a318"><label>318</label><institution>Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo</institution>, Tokyo 113-0033,<country>Japan</country></aff><aff id="a319"><label>319</label><institution>Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></aff><aff id="a320"><label>320</label><institution>Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo</institution>, Tokyo 108-8639,<country>Japan</country></aff><aff id="a321"><label>321</label><institution>Laboratory for International Alliance, RIKEN Center for Integrative Medical Sciences</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></aff><aff id="a322"><label>322</label><institution>Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></aff><aff id="a323"><label>323</label><institution>The Cardiovascular Institute, University of Pennsylvania</institution>, Philadelphia, Pennsylvania 19104,<country>USA</country></aff><aff id="a324"><label>324</label><institution>Institut für integrative und experimentelle Genomik, Universität zu Lübeck</institution>, Lübeck 23562,<country>Germany</country></aff><aff id="a325"><label>325</label><institution>Deutsches Herzzentrum München, Technische Universität München</institution>, München 80636,<country>Germany</country></aff><aff id="a326"><label>326</label><institution>Department of Medicine, Stanford University School of Medicine</institution>, Stanford, 94305-5101 California,<country>USA</country></aff><aff id="a327"><label>327</label><institution>Division of Cardiovascular and Neuronal Remodelling, Multidisciplinary Cardiovascular Research Centre, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds</institution>, Leeds LS2 9JT,<country>UK</country></aff><aff id="a328"><label>328</label><institution>Klinik und Poliklinik für Innere Medizin II, Universität Regensburg</institution>, 93053 Regensburg,<country>Germany</country></aff><aff id="a329"><label>329</label><institution>Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck</institution>, 23562 Lübeck,<country>Germany</country></aff><aff id="a330"><label>330</label><institution>Science Center, Tampere University Hospital</institution>, Tampere 33521,<country>Finland</country></aff><aff id="a331"><label>331</label><institution>The John & Jennifer Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute</institution>, Ottawa, Ontario K1Y 4W7,<country>Canada</country></aff><aff id="a332"><label>332</label><institution>deCODE Genetics</institution>, Reykjavik 101,<country>Iceland</country></aff><aff id="a333"><label>333</label><institution>Faculty of Medicine, University of Iceland</institution>, Reykjavik 101,<country>Iceland</country></aff><aff id="a334"><label>334</label><institution>Hudson Alpha Institute</institution>, Huntsville, 35806 Alabama,<country>USA</country></aff><aff id="a335"><label>335</label><institution>Cardiovascular Research Methods Centre, University of Ottawa Heart Institute</institution>, 40 Ruskin Street, Ottawa, Ontario K1Y 4W7,<country>Canada</country></aff><aff id="a336"><label>336</label><institution>The Blavatnik School of Computer Science, Department of Molecular Microbiology and Biotechnology, Tel-Aviv University</institution>, Tel-Aviv 6997801,<country>Israel</country></aff><aff id="a337"><label>337</label><institution>The International Computer Science Institute</institution>, Berkeley, 94704 California,<country>USA</country></aff><aff id="a338"><label>338</label><institution>Biostatistics and Epidemiology, University of Pennsylvania</institution>, Philadelphia, 19104 Pennsylvania,<country>USA</country></aff><aff id="a339"><label>339</label><institution>Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital</institution>, Boston, 02114 Massachusetts,<country>USA</country></aff><aff id="a340"><label>340</label><institution>Center for Human Genetic Research, Massachusetts General Hospital</institution>, Boston, 02114 Massachusetts,<country>USA</country></aff><aff id="a341"><label>341</label><institution>Division of Research, Kaiser Permanente</institution>, Oakland, 94611 California,<country>USA</country></aff><aff id="a342"><label>342</label><institution>Institute for Human Genetics, University of California, San Francisco</institution>, San Francisco, 94143 California,<country>USA</country></aff><aff id="a343"><label>343</label><institution>Department of Cardiovascular Medicine</institution>, Cleveland Clinic 7255 Old Oak Blvd, Cleveland, Ohio 44130,<country>USA</country></aff><aff id="a344"><label>344</label><institution>Medizinische Klinik und Poliklinik, Johannes-Gutenberg Universität Mainz, Universitätsmedizin</institution>, 55122 Mainz,<country>Germany</country></aff><aff id="a345"><label>345</label><institution>Institut für Klinische Chemie und Laboratoriumsmediizin, Johannes-Gutenberg Universität Mainz, Universitätsmedizin</institution>, 55122 Mainz,<country>Germany</country></aff><aff id="a346"><label>346</label><institution>INSERM UMRS 937, Pierre and Marie Curie University (UPMC, Paris 6) and Medical School</institution>, 75005 Paris,<country>France</country></aff><aff id="a347"><label>347</label><institution>Boston University, School of Public Health</institution>, Boston, 02118 Massachusetts,<country>USA</country></aff><aff id="a348"><label>348</label><institution>University of Minnesota School of Public Health, Division of Epidemiology and Community Health, School of Public Health (A.R.F.)</institution>, Minneapolis, 55454 Minnesota,<country>USA</country></aff><aff id="a349"><label>349</label><institution>University of Washington, Department of Internal Medicine</institution>, Seattle, 98195-6420 Washington,<country>USA</country></aff><aff id="a350"><label>350</label><institution>University of Texas, School of Public Health</institution>, Houston, 77030 Texas,<country>USA</country></aff><aff id="a351"><label>351</label><institution>Department of Medicine, Landspitali University Hospital</institution>, Reykjavik 101,<country>Iceland</country></aff><aff id="a352"><label>352</label><institution>Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health</institution>, 85764 Neuherberg,<country>Germany</country></aff><aff id="a353"><label>353</label><institution>Division of Endocrinology and Diabetes, Graduate School of Molecular Endocrinology and Diabetes, University of Ulm</institution>, 89069 Ulm,<country>Germany</country></aff><aff id="a354"><label>354</label><institution>Division of Endocrinology, Department of Medicine, Medical University of Graz</institution>, 8010 Graz,<country>Austria</country></aff><aff id="a355"><label>355</label><institution>Synlab Center of Laboratory Diagnostics Heidelberg</institution>, 69037 Heidelberg,<country>Germany</country></aff><aff id="a356"><label>356</label><institution>Division of Clinical Chemistry, Department of Medicine, Albert Ludwigs University</institution>, 79085 Freiburg,<country>Germany</country></aff><aff id="a357"><label>357</label><institution>Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz</institution>, 8010 Graz,<country>Austria</country></aff><aff id="a358"><label>358</label><institution>Cardiology Group Frankfurt-Sachsenhausen</institution>, 60594 Frankfurt,<country>Germany</country></aff><aff id="a359"><label>359</label><institution>The Center for Applied Genomics, Children's Hospital of Philadelphia</institution>, 19104 Philadelphia, Pennsylvania,<country>USA</country></aff><aff id="a360"><label>360</label><institution>Cardiovascular Research Institute, Medstar Health Research Institute, Washington Hospital Center</institution>, Washington, DC 20010,<country>USA</country></aff><aff id="a361"><label>361</label><institution>Genetics Division and Drug Discovery, GlaxoSmithKline</institution>, King of Prussia, Pennsylvania 19406,<country>USA</country></aff><aff id="a362"><label>362</label><institution>The Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania</institution>, Philadelphia, 19104-5158 Pennsylvania,<country>USA</country></aff><aff id="a363"><label>363</label><institution>Department of Cardiovascular Surgery, University of Leicester</institution>, Leicester LE1 7RH,<country>UK</country></aff><aff id="a364"><label>364</label><institution>Division of Cardiovascular and Diabetes Research, Multidisciplinary Cardiovascular Research Centre, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds</institution>, Leeds LS2 9JT,<country>UK</country></aff><aff id="a365"><label>365</label><institution>LIGHT Research Institute, Faculty of Medicine and Health, University of Leeds</institution>, Leeds LS2 9JT,<country>UK</country></aff><aff id="a366"><label>366</label><institution>Department of Medicine, University of North Carolina at Chapel Hill</institution>, North Carolina 27516,<country>USA</country></aff><aff id="a367"><label>367</label><institution>Department of Epidemiology, University of North Carolina at Chapel Hill</institution>, North Carolina 27599-7435,<country>USA</country></aff><aff id="a368"><label>368</label><institution>National Institute of Environmental Health Sciences, Research Triangle Park</institution>, North Carolina 27709,<country>USA</country></aff><aff id="a369"><label>369</label><institution>Department of Biostatistics, University of North Carolina at Chapel Hill</institution>, North Carolina 27514,<country>USA</country></aff><aff id="a370"><label>370</label><institution>University of Texas, Houston Health Science Center</institution>, Houston, Texas 77030,<country>USA</country></aff><aff id="a371"><label>371</label><institution>Texas Heart Institute</institution>, Houston, Texas 77225-0345,<country>USA</country></aff><aff id="a372"><label>372</label><institution>Department of Internal Medicine, Division of Cardiology, Medical University Graz</institution>, Graz 8036,<country>Austria</country></aff><aff id="a373"><label>373</label><institution>Department of Medical Sciences, Uppsala University</institution>, Uppsala 75185,<country>Sweden</country></aff><aff id="a374"><label>374</label><institution>Division of Cardiovascular Diseases, Mayo Clinic</institution>, Rochester, Minnesota 55905,<country>USA</country></aff><aff id="a375"><label>375</label><institution>Institute of Medical Epidemiology, Biostatistics and Informatics, Martin Luther University of Halle-Wittenberg, Halle-Wittenberg</institution>, Halle (Saale) 06097,<country>Germany</country></aff><aff id="a376"><label>376</label><institution>Department of Cardiology, Erasmus University Medical Center</institution>, Rotterdam 3000 CA,<country>The Netherlands</country></aff><aff id="a377"><label>377</label><institution>Medical Clinic 2, University of Lübeck</institution>, Lübeck 23538,<country>Germany</country></aff><aff id="a378"><label>378</label><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institute</institution>, Stockholm 17177,<country>Sweden</country></aff><aff id="a379"><label>379</label><institution>Martin Luther University, Halle-Wittenberg</institution>, Halle (Saale) 06097,<country>Germany</country></aff><aff id="a380"><label>380</label><institution>Department of Epidemiology, University of Alabama at Birmingham</institution>, Birmingham, Alabama 35294-0022,<country>USA</country></aff><aff id="a381"><label>381</label><institution>Division of Cardiology, University of Maryland Hospital</institution>, Baltimore, Maryland 21201,<country>USA</country></aff><aff id="a382"><label>382</label><institution>Institute of Medical Biometry, Epidemiology, and Informatics, Johannes Gutenberg University</institution>, Mainz 55101,<country>Germany</country></aff><aff id="a383"><label>383</label><institution>Institute for Community Medicine, Ernst-Moritz-Arndt-Universität</institution>, Greifswald 17475,<country>Germany</country></aff></contrib-group><author-notes><corresp id="c1"><label>a</label><email>cristian.pattaro@eurac.edu</email></corresp><corresp id="c2"><label>b</label><email>anna.koettgen@uniklinik-freiburg.de</email></corresp><corresp id="c3"><label>c</label><email>foxca@nhlbi.nih.gov</email></corresp><fn id="n1"><label>*</label><p>These authors contributed equally to this work</p></fn><fn id="n2"><label>†</label><p>These authors jointly supervised this work</p></fn><fn id="n3"><label>‡</label><p>A full list of consortium members appears at the end of the paper</p></fn><fn id="n4"><label>§</label><p>deceased</p></fn></author-notes><pub-date pub-type="epub"><day>21</day><month>01</month><year>2016</year></pub-date><pub-date pub-type="collection"><year>2016</year></pub-date><volume>7</volume><elocation-id>10023</elocation-id><history><date date-type="received"><day>12</day><month>03</month><year>2015</year></date><date date-type="accepted"><day>27</day><month>10</month><year>2015</year></date></history><permissions><copyright-statement>Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.</copyright-statement><copyright-year>2016</copyright-year><copyright-holder>Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><pmc-comment>author-paid</pmc-comment>
<license-p>This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link></license-p></license></permissions><abstract><p>Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways.</p></abstract><abstract abstract-type="web-summary"><p><inline-graphic id="i1" xlink:href="ncomms10023-i1.jpg"></inline-graphic>Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro <italic>et al</italic>. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode proteins potentially related to kidney development.</p></abstract></article-meta></front><floats-group><fig id="f1"><label>Figure 1</label><caption><title>Discovery stage genome-wide association analysis.</title><p>Manhattan plots for eGFRcrea, CKD and eGFRcys. Previously reported loci are highlighted in light blue (grey labels). (<bold>a</bold>) Novel loci uncovered for eGFRcrea in the overall and in the non-diabetes groups are highlighted in blue and green, respectively. (<bold>b</bold>) Results from CKD analysis with highlighted known and novel loci for eGFRcrea. (<bold>c</bold>) Results from eGFRcys with highlighted known and novel loci for eGFRcrea and known eGFRcys loci.</p></caption><graphic xlink:href="ncomms10023-f1"></graphic></fig><fig id="f2"><label>Figure 2</label><caption><title>Association eGFRcrea loci in subjects with and without diabetes.</title><p>Novel (<bold>a</bold>) and known (<bold>b</bold>) loci were considered. Displayed are effects and their 95% confidence intervals on ln(eGFRcrea). Results are sorted by increasing effects in the diabetes group. The majority of loci demonstrated similar effect sizes in the diabetes as compared with non-diabetes strata. SNP-specific information and detailed sample sizes are reported in <xref ref-type="supplementary-material" rid="S1">Supplementary Table 5</xref>.</p></caption><graphic xlink:href="ncomms10023-f2"></graphic></fig><fig id="f3"><label>Figure 3</label><caption><title>Bioinformatic analysis of eGFR-associated SNPs.</title><p>Connection of eGFR-associated SNPs to gene expression and variant function across a variety of tissues, pathways and regulatory marks was considered. (<bold>a</bold>) The DEPICT method shows that implicated eGFR-associated genes are highly expressed in particular tissues, including kidney and urinary tract. Shown are permutation test <italic>P</italic> values (see Methods). (<bold>b</bold>) Enrichment of eGFRcrea-associated SNPs in DHS according to discovery <italic>P</italic> value threshold. SNPs from the eGFR discovery genome-wide scan meeting a series of <italic>P</italic> value thresholds in the range 10<sup>−4</sup>–10<sup>−16</sup> preferentially map to DHSs, when compared with a set of control SNPs, in 6 of 123 cell types. Represented are main effects odds ratios from a logistic mixed effect model. Cell types indicated with coloured lines had nominally significant enrichment (* indicate <italic>P</italic> values <0.05) at the <italic>P</italic> value <10<sup>−16</sup> threshold and/or were derived from renal tissues (H7esDiffa2d: H7 embryonic stem cells, differentiated 2 days with BMP4, activin A and bFGF; Hae, amniotic epithelial cells; Hrce, renal cortical epithelial cells; Hre, renal epithelial cells; Hrgec, renal glomerular endothelial cells; Rptec, renal proximal tubule epithelial cells; Saec, small airway epithelial cells). (<bold>c</bold>) ENCODE/Chromatin ChIP-seq mapping: known and replicated novel eGFRcrea-associated SNPs and their perfect proxies were annotated based on genomic location using chromatin annotation maps from different tissues including adult kidney epithelial cells. <italic>P</italic> values from Fishers' exact tests for 2 × 2 tables are reported (significance level=5.6 × 10<sup>−3</sup>, see Methods). There is significant enrichment of variants mapping to enhancer regions specifically in kidney but not other non-renal tissues.</p></caption><graphic xlink:href="ncomms10023-f3"></graphic></fig><fig id="f4"><label>Figure 4</label><caption><title>Gene set overlap analysis.</title><p>The 19 reconstituted gene sets with <italic>P</italic> value<10<sup>−5</sup> were considered. Their overlap was estimated by computing the pairwise Pearson correlation coefficient <italic>ρ</italic> between each pair of gene sets followed by discretization into one of three bins: 0.3≤<italic>ρ</italic><0.5, low overlap; 0.5≤<italic>ρ</italic><0.7, medium overlap; <italic>ρ</italic>⩾0.7, high overlap. Overlap is shown by edges between gene set nodes and edges representing overlap corresponding to <italic>ρ</italic><0.3 are not shown. The network was drawn with Cytoscape<xref ref-type="bibr" rid="b48">48</xref>.</p></caption><graphic xlink:href="ncomms10023-f4"></graphic></fig><table-wrap position="float" id="t1"><label>Table 1</label><caption><title>The 24 novel SNPs associated with eGFRcrea in European ancestry individuals.</title></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col><col align="char" char="."></col><col align="char" char="."></col><col align="left"></col><col align="left"></col><col align="left"></col><col align="char" char="."></col><col align="left"></col><col align="char" char="."></col><col align="left"></col><col align="char" char="."></col><col align="left"></col><col align="char" char="."></col></colgroup><thead valign="bottom"><tr><th align="left" valign="top" charoff="50"><bold>SNP ID</bold><xref ref-type="fn" rid="t1-fn2">*</xref></th><th align="center" valign="top" char="." charoff="50"><bold>Chr.</bold></th><th align="center" valign="top" char="." charoff="50"><bold>Position (bp)</bold><xref ref-type="fn" rid="t1-fn3">†</xref></th><th align="left" valign="top" charoff="50"><bold>Locus name</bold><xref ref-type="fn" rid="t1-fn4">‡</xref></th><th align="center" valign="top" charoff="50"><bold>Effect/Non effect allele (EAF)</bold></th><th align="left" valign="top" charoff="50"><bold>SNP function</bold><xref ref-type="fn" rid="t1-fn5">§</xref></th><th colspan="2" align="center" valign="top" char="." charoff="50"><bold>Stage 1 (discovery)</bold><xref ref-type="fn" rid="t1-fn6">||</xref></th><th colspan="2" align="center" valign="top" char="." charoff="50"><bold>Stage 2 (replication)</bold></th><th colspan="3" align="center" valign="top" char="." charoff="50"><bold>Combined analysis</bold><xref ref-type="fn" rid="t1-fn7">¶</xref></th></tr></thead><tbody valign="top"><tr><td align="left" valign="top" charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td><td align="left" valign="top" charoff="50"> </td><td align="left" valign="top" charoff="50"> </td><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" char="." charoff="50"><bold>Beta</bold></td><td align="left" valign="top" charoff="50"><italic><bold>P</bold></italic><bold>value</bold></td><td align="center" valign="top" char="." charoff="50"><bold>Beta</bold></td><td align="left" valign="top" charoff="50"><italic><bold>q</bold></italic><bold>-value</bold></td><td align="center" valign="top" char="." charoff="50"><bold>Beta</bold></td><td align="left" valign="top" charoff="50"><italic><bold>P</bold></italic><bold>value</bold><xref ref-type="fn" rid="t1-fn8">#</xref></td><td align="char" valign="top" char="." charoff="50"><italic><bold>I</bold></italic><sup><bold>2</bold></sup><bold>%</bold><xref ref-type="fn" rid="t1-fn9">**</xref></td></tr><tr><td colspan="13" align="center" valign="top" charoff="50"><italic>The eight loci whose smallest P value was observed in the ‘no diabetes' group</italic></td></tr><tr><td align="left" valign="top" charoff="50"> rs3850625</td><td align="char" valign="top" char="." charoff="50">1</td><td align="char" valign="top" char="." charoff="50">201,016,296</td><td align="left" valign="top" charoff="50"><italic>CACNA1S</italic></td><td align="left" valign="top" charoff="50">A/G (0.12)</td><td align="left" valign="top" charoff="50">Exonic, nonsyn. SNV</td><td align="char" valign="top" char="." charoff="50">0.0080</td><td align="left" valign="top" charoff="50">2.55E−09</td><td align="char" valign="top" char="." charoff="50">0.0071</td><td align="left" valign="top" charoff="50">5.46E−03</td><td align="char" valign="top" char="." charoff="50">0.0083</td><td align="left" valign="top" charoff="50">6.82E−11</td><td align="char" valign="top" char="." charoff="50">0</td></tr><tr><td align="left" valign="top" charoff="50"> rs2712184</td><td align="char" valign="top" char="." charoff="50">2</td><td align="char" valign="top" char="." charoff="50">217,682,779</td><td align="left" valign="top" charoff="50"><italic>IGFBP5</italic></td><td align="left" valign="top" charoff="50">A/C (0.58)</td><td align="left" valign="top" charoff="50">Intergenic</td><td align="char" valign="top" char="." charoff="50">−0.0049</td><td align="left" valign="top" charoff="50">1.65E−08</td><td align="char" valign="top" char="." charoff="50">−0.0055</td><td align="left" valign="top" charoff="50">2.06E−03</td><td align="char" valign="top" char="." charoff="50">−0.0053</td><td align="left" valign="top" charoff="50">1.33E−10</td><td align="char" valign="top" char="." charoff="50">0</td></tr><tr><td align="left" valign="top" charoff="50"> rs9682041</td><td align="char" valign="top" char="." charoff="50">3</td><td align="char" valign="top" char="." charoff="50">170,091,902</td><td align="left" valign="top" charoff="50"><italic>SKIL</italic></td><td align="left" valign="top" charoff="50">T/C (0.87)</td><td align="left" valign="top" charoff="50">Intronic</td><td align="char" valign="top" char="." charoff="50">−0.0067</td><td align="left" valign="top" charoff="50">1.36E−07</td><td align="char" valign="top" char="." charoff="50">−0.0046</td><td align="left" valign="top" charoff="50">2.33E−02</td><td align="char" valign="top" char="." charoff="50">−0.0068</td><td align="left" valign="top" charoff="50">2.58E−08</td><td align="char" valign="top" char="." charoff="50">2</td></tr><tr><td align="left" valign="top" charoff="50"> rs10513801</td><td align="char" valign="top" char="." charoff="50">3</td><td align="char" valign="top" char="." charoff="50">185,822,353</td><td align="left" valign="top" charoff="50"><italic>ETV5</italic></td><td align="left" valign="top" charoff="50">T/G (0.87)</td><td align="left" valign="top" charoff="50">Intronic</td><td align="char" valign="top" char="." charoff="50">0.0070</td><td align="left" valign="top" charoff="50">3.80E−09</td><td align="char" valign="top" char="." charoff="50">0.0046</td><td align="left" valign="top" charoff="50">1.79E−02</td><td align="char" valign="top" char="." charoff="50">0.0072</td><td align="left" valign="top" charoff="50">1.03E−09</td><td align="char" valign="top" char="." charoff="50">0</td></tr><tr><td align="left" valign="top" charoff="50"> rs10994860</td><td align="char" valign="top" char="." charoff="50">10</td><td align="char" valign="top" char="." charoff="50">52,645,424</td><td align="left" valign="top" charoff="50"><italic>A1CF</italic></td><td align="left" valign="top" charoff="50">T/C (0.19)</td><td align="left" valign="top" charoff="50">UTR5</td><td align="char" valign="top" char="." charoff="50">0.0075</td><td align="left" valign="top" charoff="50">1.00E−11</td><td align="char" valign="top" char="." charoff="50">0.0061</td><td align="left" valign="top" charoff="50">5.46E−03</td><td align="char" valign="top" char="." charoff="50">0.0077</td><td align="left" valign="top" charoff="50">1.07E−12</td><td align="char" valign="top" char="." charoff="50">2</td></tr><tr><td align="left" valign="top" charoff="50"> rs163160</td><td align="char" valign="top" char="." charoff="50">11</td><td align="char" valign="top" char="." charoff="50">2,789,955</td><td align="left" valign="top" charoff="50"><italic>KCNQ1</italic></td><td align="left" valign="top" charoff="50">A/G (0.82)</td><td align="left" valign="top" charoff="50">Intronic</td><td align="char" valign="top" char="." charoff="50">0.0067</td><td align="left" valign="top" charoff="50">9.02E−09</td><td align="char" valign="top" char="." charoff="50">0.0050</td><td align="left" valign="top" charoff="50">9.89E−03</td><td align="char" valign="top" char="." charoff="50">0.0065</td><td align="left" valign="top" charoff="50">2.26E−09</td><td align="char" valign="top" char="." charoff="50">14</td></tr><tr><td align="left" valign="top" charoff="50"> rs164748</td><td align="char" valign="top" char="." charoff="50">16</td><td align="char" valign="top" char="." charoff="50">89,708,292</td><td align="left" valign="top" charoff="50"><italic>DPEP1</italic></td><td align="left" valign="top" charoff="50">C/G (0.53)</td><td align="left" valign="top" charoff="50">Intergenic</td><td align="char" valign="top" char="." charoff="50">0.0047</td><td align="left" valign="top" charoff="50">9.92E−09</td><td align="char" valign="top" char="." charoff="50">0.0019</td><td align="left" valign="top" charoff="50">4.19E−02</td><td align="char" valign="top" char="." charoff="50">0.0046</td><td align="left" valign="top" charoff="50">1.95E−08</td><td align="char" valign="top" char="." charoff="50">17</td></tr><tr><td align="left" valign="top" charoff="50"> rs8091180</td><td align="char" valign="top" char="." charoff="50">18</td><td align="char" valign="top" char="." charoff="50">77,164,243</td><td align="left" valign="top" charoff="50"><italic>NFATC1</italic></td><td align="left" valign="top" charoff="50">A/G (0.56)</td><td align="left" valign="top" charoff="50">Intronic</td><td align="char" valign="top" char="." charoff="50">−0.0054</td><td align="left" valign="top" charoff="50">1.43E−08</td><td align="char" valign="top" char="." charoff="50">−0.0052</td><td align="left" valign="top" charoff="50">5.46E−03</td><td align="char" valign="top" char="." charoff="50">−0.0060</td><td align="left" valign="top" charoff="50">1.28E−09</td><td align="char" valign="top" char="." charoff="50">0</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td><td align="left" valign="top" charoff="50"> </td><td align="left" valign="top" charoff="50"> </td><td align="left" valign="top" charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td><td align="left" valign="top" charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td><td align="left" valign="top" charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td><td align="left" valign="top" charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td></tr><tr><td colspan="13" align="center" valign="top" charoff="50"><italic>The 16 loci whose smallest P value was observed in the ‘overall' group</italic></td></tr><tr><td align="left" valign="top" charoff="50"> rs12136063</td><td align="char" valign="top" char="." charoff="50">1</td><td align="char" valign="top" char="." charoff="50">110,014,170</td><td align="left" valign="top" charoff="50"><italic>SYPL2</italic></td><td align="left" valign="top" charoff="50">A/G (0.70)</td><td align="left" valign="top" charoff="50">Intronic</td><td align="char" valign="top" char="." charoff="50">0.0049</td><td align="left" valign="top" charoff="50">2.33E−07</td><td align="char" valign="top" char="." charoff="50">0.0028</td><td align="left" valign="top" charoff="50">2.31E−02</td><td align="char" valign="top" char="." charoff="50">0.0045</td><td align="left" valign="top" charoff="50">4.71E−08</td><td align="char" valign="top" char="." charoff="50">0</td></tr><tr><td align="left" valign="top" charoff="50"> rs2802729</td><td align="char" valign="top" char="." charoff="50">1</td><td align="char" valign="top" char="." charoff="50">243,501,763</td><td align="left" valign="top" charoff="50"><italic>SDCCAG8</italic></td><td align="left" valign="top" charoff="50">A/C (0.43)</td><td align="left" valign="top" charoff="50">Intronic</td><td align="char" valign="top" char="." charoff="50">−0.0050</td><td align="left" valign="top" charoff="50">7.37E−08</td><td align="char" valign="top" char="." charoff="50">−0.0029</td><td align="left" valign="top" charoff="50">2.05E−02</td><td align="char" valign="top" char="." charoff="50">−0.0046</td><td align="left" valign="top" charoff="50">2.20E−08</td><td align="char" valign="top" char="." charoff="50">9</td></tr><tr><td align="left" valign="top" charoff="50"> rs4667594</td><td align="char" valign="top" char="." charoff="50">2</td><td align="char" valign="top" char="." charoff="50">170,008,506</td><td align="left" valign="top" charoff="50"><italic>LRP2</italic></td><td align="left" valign="top" charoff="50">A/T (0.53)</td><td align="left" valign="top" charoff="50">Intronic</td><td align="char" valign="top" char="." charoff="50">−0.0045</td><td align="left" valign="top" charoff="50">2.37E−07</td><td align="char" valign="top" char="." charoff="50">−0.0043</td><td align="left" valign="top" charoff="50">5.62E−03</td><td align="char" valign="top" char="." charoff="50">−0.0044</td><td align="left" valign="top" charoff="50">3.52E−08</td><td align="char" valign="top" char="." charoff="50">4</td></tr><tr><td align="left" valign="top" charoff="50"> rs6795744<xref ref-type="fn" rid="t1-fn10">‡‡</xref></td><td align="char" valign="top" char="." charoff="50">3</td><td align="char" valign="top" char="." charoff="50">13,906,850</td><td align="left" valign="top" charoff="50"><italic>WNT7A</italic></td><td align="left" valign="top" charoff="50">A/G (0.15)</td><td align="left" valign="top" charoff="50">Intronic</td><td align="char" valign="top" char="." charoff="50">0.0071</td><td align="left" valign="top" charoff="50">9.60E−09</td><td align="char" valign="top" char="." charoff="50">0.0019</td><td align="left" valign="top" charoff="50">5.15E−02</td><td align="char" valign="top" char="." charoff="50">0.0060</td><td align="left" valign="top" charoff="50">3.33E−08</td><td align="char" valign="top" char="." charoff="50">18</td></tr><tr><td align="left" valign="top" charoff="50"> rs228611</td><td align="char" valign="top" char="." charoff="50">4</td><td align="char" valign="top" char="." charoff="50">103,561,709</td><td align="left" valign="top" charoff="50"><italic>NFKB1</italic></td><td align="left" valign="top" charoff="50">A/G (0.47)</td><td align="left" valign="top" charoff="50">Intronic</td><td align="char" valign="top" char="." charoff="50">−0.0055</td><td align="left" valign="top" charoff="50">4.66E−10</td><td align="char" valign="top" char="." charoff="50">−0.0060</td><td align="left" valign="top" charoff="50">8.91E−04</td><td align="char" valign="top" char="." charoff="50">−0.0056</td><td align="left" valign="top" charoff="50">3.58E−12</td><td align="char" valign="top" char="." charoff="50">3</td></tr><tr><td align="left" valign="top" charoff="50"> rs7759001</td><td align="char" valign="top" char="." charoff="50">6</td><td align="char" valign="top" char="." charoff="50">27,341,409</td><td align="left" valign="top" charoff="50"><italic>ZNF204</italic></td><td align="left" valign="top" charoff="50">A/G (0.76)</td><td align="left" valign="top" charoff="50">ncRNA intronic</td><td align="char" valign="top" char="." charoff="50">−0.0053</td><td align="left" valign="top" charoff="50">2.64E−07</td><td align="char" valign="top" char="." charoff="50">−0.0045</td><td align="left" valign="top" charoff="50">9.10E−03</td><td align="char" valign="top" char="." charoff="50">−0.0051</td><td align="left" valign="top" charoff="50">1.75E−08</td><td align="char" valign="top" char="." charoff="50">0</td></tr><tr><td align="left" valign="top" charoff="50"> rs10277115</td><td align="char" valign="top" char="." charoff="50">7</td><td align="char" valign="top" char="." charoff="50">1,285,195</td><td align="left" valign="top" charoff="50"><italic>UNCX</italic></td><td align="left" valign="top" charoff="50">A/T (0.23)</td><td align="left" valign="top" charoff="50">Intergenic</td><td align="char" valign="top" char="." charoff="50">0.0095</td><td align="left" valign="top" charoff="50">1.05E−10</td><td align="char" valign="top" char="." charoff="50">0.0079</td><td align="left" valign="top" charoff="50">9.03E−04</td><td align="char" valign="top" char="." charoff="50">0.0090</td><td align="left" valign="top" charoff="50">8.72E−14</td><td align="char" valign="top" char="." charoff="50">0</td></tr><tr><td align="left" valign="top" charoff="50"> rs3750082</td><td align="char" valign="top" char="." charoff="50">7</td><td align="char" valign="top" char="." charoff="50">32,919,927</td><td align="left" valign="top" charoff="50"><italic>KBTBD2</italic></td><td align="left" valign="top" charoff="50">A/T (0.33)</td><td align="left" valign="top" charoff="50">Intronic</td><td align="char" valign="top" char="." charoff="50">0.0049</td><td align="left" valign="top" charoff="50">2.52E−07</td><td align="char" valign="top" char="." charoff="50">0.0031</td><td align="left" valign="top" charoff="50">1.96E−02</td><td align="char" valign="top" char="." charoff="50">0.0045</td><td align="left" valign="top" charoff="50">3.22E−08</td><td align="char" valign="top" char="." charoff="50">2</td></tr><tr><td align="left" valign="top" charoff="50"> rs6459680</td><td align="char" valign="top" char="." charoff="50">7</td><td align="char" valign="top" char="." charoff="50">156,258,568</td><td align="left" valign="top" charoff="50"><italic>RNF32</italic></td><td align="left" valign="top" charoff="50">T/G (0.74)</td><td align="left" valign="top" charoff="50">Intergenic</td><td align="char" valign="top" char="." charoff="50">−0.0065</td><td align="left" valign="top" charoff="50">1.96E−10</td><td align="char" valign="top" char="." charoff="50">−0.0019</td><td align="left" valign="top" charoff="50">4.62E−02</td><td align="char" valign="top" char="." charoff="50">−0.0055</td><td align="left" valign="top" charoff="50">1.07E−09</td><td align="char" valign="top" char="." charoff="50">0</td></tr><tr><td align="left" valign="top" charoff="50"> rs4014195</td><td align="char" valign="top" char="." charoff="50">11</td><td align="char" valign="top" char="." charoff="50">65,506,822</td><td align="left" valign="top" charoff="50"><italic>AP5B1</italic></td><td align="left" valign="top" charoff="50">C/G (0.64)</td><td align="left" valign="top" charoff="50">Intergenic</td><td align="char" valign="top" char="." charoff="50">0.0061</td><td align="left" valign="top" charoff="50">2.19E−11</td><td align="char" valign="top" char="." charoff="50">0.0034</td><td align="left" valign="top" charoff="50">1.42E−02</td><td align="char" valign="top" char="." charoff="50">0.0055</td><td align="left" valign="top" charoff="50">1.10E−11</td><td align="char" valign="top" char="." charoff="50">0</td></tr><tr><td align="left" valign="top" charoff="50"> rs10491967</td><td align="char" valign="top" char="." charoff="50">12</td><td align="char" valign="top" char="." charoff="50">3,368,093</td><td align="left" valign="top" charoff="50"><italic>TSPAN9</italic></td><td align="left" valign="top" charoff="50">A/G (0.10)</td><td align="left" valign="top" charoff="50">Intronic</td><td align="char" valign="top" char="." charoff="50">−0.0092</td><td align="left" valign="top" charoff="50">3.03E−10</td><td align="char" valign="top" char="." charoff="50">−0.0106</td><td align="left" valign="top" charoff="50">3.93E−04</td><td align="char" valign="top" char="." charoff="50">−0.0095</td><td align="left" valign="top" charoff="50">5.18E−14</td><td align="char" valign="top" char="." charoff="50">0</td></tr><tr><td align="left" valign="top" charoff="50"> rs7956634</td><td align="char" valign="top" char="." charoff="50">12</td><td align="char" valign="top" char="." charoff="50">15,321,194</td><td align="left" valign="top" charoff="50"><italic>PTPRO</italic></td><td align="left" valign="top" charoff="50">T/C (0.81)</td><td align="left" valign="top" charoff="50">Intronic</td><td align="char" valign="top" char="." charoff="50">−0.0068</td><td align="left" valign="top" charoff="50">2.46E−09</td><td align="char" valign="top" char="." charoff="50">−0.0069</td><td align="left" valign="top" charoff="50">1.51E−03</td><td align="char" valign="top" char="." charoff="50">−0.0068</td><td align="left" valign="top" charoff="50">7.17E−12</td><td align="char" valign="top" char="." charoff="50">0</td></tr><tr><td align="left" valign="top" charoff="50"> rs1106766</td><td align="char" valign="top" char="." charoff="50">12</td><td align="char" valign="top" char="." charoff="50">57,809,456</td><td align="left" valign="top" charoff="50"><italic>INHBC</italic></td><td align="left" valign="top" charoff="50">T/C (0.22)</td><td align="left" valign="top" charoff="50">Intergenic</td><td align="char" valign="top" char="." charoff="50">0.0062</td><td align="left" valign="top" charoff="50">4.67E−08</td><td align="char" valign="top" char="." charoff="50">0.0058</td><td align="left" valign="top" charoff="50">8.79E−03</td><td align="char" valign="top" char="." charoff="50">0.0061</td><td align="left" valign="top" charoff="50">2.41E−09</td><td align="char" valign="top" char="." charoff="50">9</td></tr><tr><td align="left" valign="top" charoff="50"> rs11666497</td><td align="char" valign="top" char="." charoff="50">19</td><td align="char" valign="top" char="." charoff="50">38,464,262</td><td align="left" valign="top" charoff="50"><italic>SIPA1L3</italic></td><td align="left" valign="top" charoff="50">T/C (0.18)</td><td align="left" valign="top" charoff="50">Intronic</td><td align="char" valign="top" char="." charoff="50">−0.0064</td><td align="left" valign="top" charoff="50">8.58E−08</td><td align="char" valign="top" char="." charoff="50">−0.0041</td><td align="left" valign="top" charoff="50">1.53E−02</td><td align="char" valign="top" char="." charoff="50">−0.0058</td><td align="left" valign="top" charoff="50">4.25E−08</td><td align="char" valign="top" char="." charoff="50">24</td></tr><tr><td align="left" valign="top" charoff="50"> rs6088580</td><td align="char" valign="top" char="." charoff="50">20</td><td align="char" valign="top" char="." charoff="50">33,285,053</td><td align="left" valign="top" charoff="50"><italic>TP53INP2</italic></td><td align="left" valign="top" charoff="50">C/G (0.47)</td><td align="left" valign="top" charoff="50">Intergenic</td><td align="char" valign="top" char="." charoff="50">−0.0055</td><td align="left" valign="top" charoff="50">7.17E−10</td><td align="char" valign="top" char="." charoff="50">−0.0027</td><td align="left" valign="top" charoff="50">2.31E−02</td><td align="char" valign="top" char="." charoff="50">−0.0049</td><td align="left" valign="top" charoff="50">1.79E−09</td><td align="char" valign="top" char="." charoff="50">0</td></tr><tr><td align="left" valign="top" charoff="50"> rs17216707</td><td align="char" valign="top" char="." charoff="50">20</td><td align="char" valign="top" char="." charoff="50">52,732,362</td><td align="left" valign="top" charoff="50"><italic>BCAS1</italic></td><td align="left" valign="top" charoff="50">T/C (0.79)</td><td align="left" valign="top" charoff="50">Intergenic</td><td align="char" valign="top" char="." charoff="50">−0.0084</td><td align="left" valign="top" charoff="50">5.96E−13</td><td align="char" valign="top" char="." charoff="50">−0.0051</td><td align="left" valign="top" charoff="50">6.69E−03</td><td align="char" valign="top" char="." charoff="50">−0.0077</td><td align="left" valign="top" charoff="50">8.83E−15</td><td align="char" valign="top" char="." charoff="50">1</td></tr></tbody></table><table-wrap-foot><fn id="t1-fn1"><p>bp, basepairs; Chr, chromosome; EAF, effect allele frequency; eGFRcrea, eGFR based on serum creatinine; GWAS, genome-wide association studies; SNP, single-nucleotide polymorphism; UTR, untranslated region.</p></fn><fn id="t1-fn2"><p><sup>*</sup>SNPs are grouped by the stratum where the smallest <italic>P</italic> value in the discovery and combined analysis was observed. In the ‘no diabetes' group, sample size/number of studies were equal to 118,448/45, 36,433/13 and 154,881/58, in the discovery, replication and combined analyses, respectively. In the ‘overall' group, the numbers for the three analyses were equal to 133,413/48, 42,116/14 and 175,579/62, respectively.</p></fn><fn id="t1-fn3"><p><sup>†</sup>On the basis of RefSeq genes (build 37).</p></fn><fn id="t1-fn4"><p><sup>‡</sup>Conventional locus name based on relevant genes in the region as identified by bioinformatic investigation (<xref ref-type="supplementary-material" rid="S1">Supplementary Table 12</xref>) or closest gene. A complete overview of the genes in each locus is given in the regional association plots (<xref ref-type="supplementary-material" rid="S1">Supplementary Fig. 4</xref>).</p></fn><fn id="t1-fn5"><p><sup>§</sup>SNP function is derived from NCBI RefSeq genes and may not correspond to the named gene.</p></fn><fn id="t1-fn6"><p><sup>||</sup>Twice genomic-control (GC) corrected <italic>P</italic> value from discovery GWAS meta-analysis: at the individual study level and after the meta-analysis.</p></fn><fn id="t1-fn7"><p><sup>¶</sup>For random-effect estimate, see <xref ref-type="supplementary-material" rid="S1">Supplementary Table 4</xref>.</p></fn><fn id="t1-fn8"><p><sup>#</sup><italic>P</italic> value of the meta-analysis of the twice GC-corrected discovery meta-analysis results and replication studies.</p></fn><fn id="t1-fn9"><p><sup>**</sup>Between-study heterogeneity, as assessed by the I<sup>2</sup>. Q statistic <italic>P</italic> value >0.05 for all SNPs, except rs11666497 (<italic>SIPA1L3</italic>, <italic>P</italic> value=0.04).</p></fn><fn id="t1-fn10"><p><sup>‡‡</sup>For this SNP, the conditions for replication were not all met (<italic>q</italic>-value >0.05 in the replication stage).</p></fn></table-wrap-foot></table-wrap></floats-group></pmc><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Canada</li><li>Croatie</li><li>Estonie</li><li>Finlande</li><li>France</li><li>Irlande (pays)</li><li>Islande</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suisse</li><li>Suède</li><li>États-Unis</li></country><region><li>Hambourg</li></region><settlement><li>Hambourg</li></settlement></list><tree><country name="Italie"><noRegion><name sortKey="Pattaro, Cristian" sort="Pattaro, Cristian" uniqKey="Pattaro C" first="Cristian" last="Pattaro">Cristian Pattaro</name></noRegion><name sortKey="Ciullo, Marina" sort="Ciullo, Marina" uniqKey="Ciullo M" first="Marina" last="Ciullo">Marina Ciullo</name><name sortKey="Cocca, Massimiliano" sort="Cocca, Massimiliano" uniqKey="Cocca M" first="Massimiliano" last="Cocca">Massimiliano Cocca</name><name sortKey="Cusi, Daniele" sort="Cusi, Daniele" uniqKey="Cusi D" first="Daniele" last="Cusi">Daniele Cusi</name><name sortKey="D Adamo, Pio" sort="D Adamo, Pio" uniqKey="D Adamo P" first="Pio" last="D'Adamo">Pio D'Adamo</name><name sortKey="Fuchsberger, Christian" sort="Fuchsberger, Christian" uniqKey="Fuchsberger C" first="Christian" last="Fuchsberger">Christian Fuchsberger</name><name sortKey="Gambaro, Giovanni" sort="Gambaro, Giovanni" uniqKey="Gambaro G" first="Giovanni" last="Gambaro">Giovanni Gambaro</name><name sortKey="Gasparini, Paolo" sort="Gasparini, Paolo" uniqKey="Gasparini P" first="Paolo" last="Gasparini">Paolo Gasparini</name><name sortKey="Lupo, Antonio" sort="Lupo, Antonio" uniqKey="Lupo A" first="Antonio" last="Lupo">Antonio Lupo</name><name sortKey="Malerba, Giovanni" sort="Malerba, Giovanni" uniqKey="Malerba G" first="Giovanni" last="Malerba">Giovanni Malerba</name><name sortKey="Mijatovic, Vladan" sort="Mijatovic, Vladan" uniqKey="Mijatovic V" first="Vladan" last="Mijatovic">Vladan Mijatovic</name><name sortKey="Murgia, Federico" sort="Murgia, Federico" uniqKey="Murgia F" first="Federico" last="Murgia">Federico Murgia</name><name sortKey="Persico, Ivana" sort="Persico, Ivana" uniqKey="Persico I" first="Ivana" last="Persico">Ivana Persico</name><name sortKey="Pirastu, Mario" sort="Pirastu, Mario" uniqKey="Pirastu M" first="Mario" last="Pirastu">Mario Pirastu</name><name sortKey="Pistis, Giorgio" sort="Pistis, Giorgio" uniqKey="Pistis G" first="Giorgio" last="Pistis">Giorgio Pistis</name><name sortKey="Portas, Laura" sort="Portas, Laura" uniqKey="Portas L" first="Laura" last="Portas">Laura Portas</name><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name><name sortKey="Robino, Antonietta" sort="Robino, Antonietta" uniqKey="Robino A" first="Antonietta" last="Robino">Antonietta Robino</name><name sortKey="Ruggiero, Daniela" sort="Ruggiero, Daniela" uniqKey="Ruggiero D" first="Daniela" last="Ruggiero">Daniela Ruggiero</name><name sortKey="Saint Pierre, Aude" sort="Saint Pierre, Aude" uniqKey="Saint Pierre A" first="Aude" last="Saint-Pierre">Aude Saint-Pierre</name><name sortKey="Sala, Cinzia" sort="Sala, Cinzia" uniqKey="Sala C" first="Cinzia" last="Sala">Cinzia Sala</name><name sortKey="Salvi, Erika" sort="Salvi, Erika" uniqKey="Salvi E" first="Erika" last="Salvi">Erika Salvi</name><name sortKey="Sorice, Rossella" sort="Sorice, Rossella" uniqKey="Sorice R" first="Rossella" last="Sorice">Rossella Sorice</name><name sortKey="Taliun, Daniel" sort="Taliun, Daniel" uniqKey="Taliun D" first="Daniel" last="Taliun">Daniel Taliun</name><name sortKey="Toniolo, Daniela" sort="Toniolo, Daniela" uniqKey="Toniolo D" first="Daniela" last="Toniolo">Daniela Toniolo</name><name sortKey="Toniolo, Daniela" sort="Toniolo, Daniela" uniqKey="Toniolo D" first="Daniela" last="Toniolo">Daniela Toniolo</name><name sortKey="Ulivi, Sheila" sort="Ulivi, Sheila" uniqKey="Ulivi S" first="Sheila" last="Ulivi">Sheila Ulivi</name></country><country name="Allemagne"><noRegion><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name></noRegion><name sortKey="Biffar, Reiner" sort="Biffar, Reiner" uniqKey="Biffar R" first="Reiner" last="Biffar">Reiner Biffar</name><name sortKey="Boger, Carsten A" sort="Boger, Carsten A" uniqKey="Boger C" first="Carsten A." last="Böger">Carsten A. Böger</name><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><name sortKey="Butterbach, Katja" sort="Butterbach, Katja" uniqKey="Butterbach K" first="Katja" last="Butterbach">Katja Butterbach</name><name sortKey="Czamara, Darina" sort="Czamara, Darina" uniqKey="Czamara D" first="Darina" last="Czamara">Darina Czamara</name><name sortKey="Dieffenbach, Aida Karina" sort="Dieffenbach, Aida Karina" uniqKey="Dieffenbach A" first="Aida Karina" last="Dieffenbach">Aida Karina Dieffenbach</name><name sortKey="Dieffenbach, Aida Karina" sort="Dieffenbach, Aida Karina" uniqKey="Dieffenbach A" first="Aida Karina" last="Dieffenbach">Aida Karina Dieffenbach</name><name sortKey="Ellinghaus, David" sort="Ellinghaus, David" uniqKey="Ellinghaus D" first="David" last="Ellinghaus">David Ellinghaus</name><name sortKey="Endlich, Karlhans" sort="Endlich, Karlhans" uniqKey="Endlich K" first="Karlhans" last="Endlich">Karlhans Endlich</name><name sortKey="Ernst, Florian" sort="Ernst, Florian" uniqKey="Ernst F" first="Florian" last="Ernst">Florian Ernst</name><name sortKey="Franke, Andre" sort="Franke, Andre" uniqKey="Franke A" first="Andre" last="Franke">Andre Franke</name><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><name sortKey="Gorski, Mathias" sort="Gorski, Mathias" uniqKey="Gorski M" first="Mathias" last="Gorski">Mathias Gorski</name><name sortKey="Gorski, Mathias" sort="Gorski, Mathias" uniqKey="Gorski M" first="Mathias" last="Gorski">Mathias Gorski</name><name sortKey="Grallert, Harald" sort="Grallert, Harald" uniqKey="Grallert H" first="Harald" last="Grallert">Harald Grallert</name><name sortKey="Grallert, Harald" sort="Grallert, Harald" uniqKey="Grallert H" first="Harald" last="Grallert">Harald Grallert</name><name sortKey="Grallert, Harald" sort="Grallert, Harald" uniqKey="Grallert H" first="Harald" last="Grallert">Harald Grallert</name><name sortKey="Heid, Iris M" sort="Heid, Iris M" uniqKey="Heid I" first="Iris M." last="Heid">Iris M. Heid</name><name sortKey="Heid, Iris M" sort="Heid, Iris M" uniqKey="Heid I" first="Iris M." last="Heid">Iris M. Heid</name><name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name><name sortKey="Jacobs, Gunnar" sort="Jacobs, Gunnar" uniqKey="Jacobs G" first="Gunnar" last="Jacobs">Gunnar Jacobs</name><name sortKey="Kleber, Marcus E" sort="Kleber, Marcus E" uniqKey="Kleber M" first="Marcus E." last="Kleber">Marcus E. Kleber</name><name sortKey="Kloiber, Stefan" sort="Kloiber, Stefan" uniqKey="Kloiber S" first="Stefan" last="Kloiber">Stefan Kloiber</name><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name><name sortKey="Kottgen, Anna" sort="Kottgen, Anna" uniqKey="Kottgen A" first="Anna" last="Köttgen">Anna Köttgen</name><name sortKey="Kovacs, Peter" sort="Kovacs, Peter" uniqKey="Kovacs P" first="Peter" last="Kovacs">Peter Kovacs</name><name sortKey="Kr Mer, Bernhard K" sort="Kr Mer, Bernhard K" uniqKey="Kr Mer B" first="Bernhard K." last="Kr Mer">Bernhard K. Kr Mer</name><name sortKey="Kroemer, Heyo K" sort="Kroemer, Heyo K" uniqKey="Kroemer H" first="Heyo K." last="Kroemer">Heyo K. Kroemer</name><name sortKey="Li, Yong" sort="Li, Yong" uniqKey="Li Y" first="Yong" last="Li">Yong Li</name><name sortKey="Lieb, Wolfgang" sort="Lieb, Wolfgang" uniqKey="Lieb W" first="Wolfgang" last="Lieb">Wolfgang Lieb</name><name sortKey="M Rz, Winfried" sort="M Rz, Winfried" uniqKey="M Rz W" first="Winfried" last="M Rz">Winfried M Rz</name><name sortKey="Meisinger, Christa" sort="Meisinger, Christa" uniqKey="Meisinger C" first="Christa" last="Meisinger">Christa Meisinger</name><name sortKey="Muller, Christian" sort="Muller, Christian" uniqKey="Muller C" first="Christian" last="Müller">Christian Müller</name><name sortKey="Muller, Christian" sort="Muller, Christian" uniqKey="Muller C" first="Christian" last="Müller">Christian Müller</name><name sortKey="Nauck, Matthias" sort="Nauck, Matthias" uniqKey="Nauck M" first="Matthias" last="Nauck">Matthias Nauck</name><name sortKey="Nauck, Matthias" sort="Nauck, Matthias" uniqKey="Nauck M" first="Matthias" last="Nauck">Matthias Nauck</name><name sortKey="Olden, Matthias" sort="Olden, Matthias" uniqKey="Olden M" first="Matthias" last="Olden">Matthias Olden</name><name sortKey="Olden, Matthias" sort="Olden, Matthias" uniqKey="Olden M" first="Matthias" last="Olden">Matthias Olden</name><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name><name sortKey="Rettig, Rainer" sort="Rettig, Rainer" uniqKey="Rettig R" first="Rainer" last="Rettig">Rainer Rettig</name><name sortKey="Rheinberger, Myriam" sort="Rheinberger, Myriam" uniqKey="Rheinberger M" first="Myriam" last="Rheinberger">Myriam Rheinberger</name><name sortKey="Stracke, Sylvia" sort="Stracke, Sylvia" uniqKey="Stracke S" first="Sylvia" last="Stracke">Sylvia Stracke</name><name sortKey="Stumvoll, Michael" sort="Stumvoll, Michael" uniqKey="Stumvoll M" first="Michael" last="Stumvoll">Michael Stumvoll</name><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><name sortKey="Tonjes, Anke" sort="Tonjes, Anke" uniqKey="Tonjes A" first="Anke" last="Tonjes">Anke Tonjes</name><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><name sortKey="Waldenberger, Melanie" sort="Waldenberger, Melanie" uniqKey="Waldenberger M" first="Melanie" last="Waldenberger">Melanie Waldenberger</name><name sortKey="Wallaschofski, Henri" sort="Wallaschofski, Henri" uniqKey="Wallaschofski H" first="Henri" last="Wallaschofski">Henri Wallaschofski</name><name sortKey="Wallaschofski, Henri" sort="Wallaschofski, Henri" uniqKey="Wallaschofski H" first="Henri" last="Wallaschofski">Henri Wallaschofski</name><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H-Erich" last="Wichmann">H-Erich Wichmann</name><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H-Erich" last="Wichmann">H-Erich Wichmann</name><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H-Erich" last="Wichmann">H-Erich Wichmann</name><name sortKey="Wild, Philipp S" sort="Wild, Philipp S" uniqKey="Wild P" first="Philipp S." last="Wild">Philipp S. Wild</name><name sortKey="Zeller, Tanja" sort="Zeller, Tanja" uniqKey="Zeller T" first="Tanja" last="Zeller">Tanja Zeller</name><name sortKey="Zeller, Tanja" sort="Zeller, Tanja" uniqKey="Zeller T" first="Tanja" last="Zeller">Tanja Zeller</name></country><country name="États-Unis"><noRegion><name sortKey="Chu, Audrey Y" sort="Chu, Audrey Y" uniqKey="Chu A" first="Audrey Y." last="Chu">Audrey Y. Chu</name></noRegion><name sortKey="Adeyemo, Adebowale" sort="Adeyemo, Adebowale" uniqKey="Adeyemo A" first="Adebowale" last="Adeyemo">Adebowale Adeyemo</name><name sortKey="Atkinson, Elizabeth J" sort="Atkinson, Elizabeth J" uniqKey="Atkinson E" first="Elizabeth J." last="Atkinson">Elizabeth J. Atkinson</name><name sortKey="Attia, John" sort="Attia, John" uniqKey="Attia J" first="John" last="Attia">John Attia</name><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><name sortKey="Borecki, Ingrid" sort="Borecki, Ingrid" uniqKey="Borecki I" first="Ingrid" last="Borecki">Ingrid Borecki</name><name sortKey="Bottinger, Erwin P" sort="Bottinger, Erwin P" uniqKey="Bottinger E" first="Erwin P." last="Bottinger">Erwin P. Bottinger</name><name sortKey="Carroll, Robert J" sort="Carroll, Robert J" uniqKey="Carroll R" first="Robert J." last="Carroll">Robert J. Carroll</name><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name><name sortKey="Chen, Ming Huei" sort="Chen, Ming Huei" uniqKey="Chen M" first="Ming-Huei" last="Chen">Ming-Huei Chen</name><name sortKey="Chen, Ming Huei" sort="Chen, Ming Huei" uniqKey="Chen M" first="Ming-Huei" last="Chen">Ming-Huei Chen</name><name sortKey="Chen, Wei Min" sort="Chen, Wei Min" uniqKey="Chen W" first="Wei-Min" last="Chen">Wei-Min Chen</name><name sortKey="Coresh, Josef" sort="Coresh, Josef" uniqKey="Coresh J" first="Josef" last="Coresh">Josef Coresh</name><name sortKey="Coresh, Josef" sort="Coresh, Josef" uniqKey="Coresh J" first="Josef" last="Coresh">Josef Coresh</name><name sortKey="Cornelis, Marilyn C" sort="Cornelis, Marilyn C" uniqKey="Cornelis M" first="Marilyn C." last="Cornelis">Marilyn C. Cornelis</name><name sortKey="Curhan, Gary C" sort="Curhan, Gary C" uniqKey="Curhan G" first="Gary C." last="Curhan">Gary C. Curhan</name><name sortKey="De Andrade, Mariza" sort="De Andrade, Mariza" uniqKey="De Andrade M" first="Mariza" last="De Andrade">Mariza De Andrade</name><name sortKey="De Boer, Ian H" sort="De Boer, Ian H" uniqKey="De Boer I" first="Ian H." last="De Boer">Ian H. De Boer</name><name sortKey="Denny, Joshua C" sort="Denny, Joshua C" uniqKey="Denny J" first="Joshua C." last="Denny">Joshua C. Denny</name><name sortKey="Ding, Jingzhong" sort="Ding, Jingzhong" uniqKey="Ding J" first="Jingzhong" last="Ding">Jingzhong Ding</name><name sortKey="Divers, Jasmin" sort="Divers, Jasmin" uniqKey="Divers J" first="Jasmin" last="Divers">Jasmin Divers</name><name sortKey="Dreisbach, Albert W" sort="Dreisbach, Albert W" uniqKey="Dreisbach A" first="Albert W." last="Dreisbach">Albert W. Dreisbach</name><name sortKey="Esko, Tonu" sort="Esko, Tonu" uniqKey="Esko T" first="Tonu" last="Esko">Tonu Esko</name><name sortKey="Evans, Michele K" sort="Evans, Michele K" uniqKey="Evans M" first="Michele K." last="Evans">Michele K. Evans</name><name sortKey="Faul, Jessica D" sort="Faul, Jessica D" uniqKey="Faul J" first="Jessica D." last="Faul">Jessica D. Faul</name><name sortKey="Feitosa, Mary F" sort="Feitosa, Mary F" uniqKey="Feitosa M" first="Mary F." last="Feitosa">Mary F. Feitosa</name><name sortKey="Fernandes, Jyotika K" sort="Fernandes, Jyotika K" uniqKey="Fernandes J" first="Jyotika K." last="Fernandes">Jyotika K. Fernandes</name><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><name sortKey="Foster, Meredith" sort="Foster, Meredith" uniqKey="Foster M" first="Meredith" last="Foster">Meredith Foster</name><name sortKey="Fox, Caroline S" sort="Fox, Caroline S" uniqKey="Fox C" first="Caroline S." last="Fox">Caroline S. Fox</name><name sortKey="Fox, Caroline S" sort="Fox, Caroline S" uniqKey="Fox C" first="Caroline S." last="Fox">Caroline S. Fox</name><name sortKey="Freedman, Barry I" sort="Freedman, Barry I" uniqKey="Freedman B" first="Barry I." last="Freedman">Barry I. Freedman</name><name sortKey="Garnaas, Maija" sort="Garnaas, Maija" uniqKey="Garnaas M" first="Maija" last="Garnaas">Maija Garnaas</name><name sortKey="Goessling, Wolfram" sort="Goessling, Wolfram" uniqKey="Goessling W" first="Wolfram" last="Goessling">Wolfram Goessling</name><name sortKey="Gottesman, Omri" sort="Gottesman, Omri" uniqKey="Gottesman O" first="Omri" last="Gottesman">Omri Gottesman</name><name sortKey="Guessous, Idris" sort="Guessous, Idris" uniqKey="Guessous I" first="Idris" last="Guessous">Idris Guessous</name><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N." last="Hirschhorn">Joel N. Hirschhorn</name><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N." last="Hirschhorn">Joel N. Hirschhorn</name><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N." last="Hirschhorn">Joel N. Hirschhorn</name><name sortKey="Hu, Frank B" sort="Hu, Frank B" uniqKey="Hu F" first="Frank B." last="Hu">Frank B. Hu</name><name sortKey="Hwang, Shih Jen" sort="Hwang, Shih Jen" uniqKey="Hwang S" first="Shih-Jen" last="Hwang">Shih-Jen Hwang</name><name sortKey="Johnson, Andrew D" sort="Johnson, Andrew D" uniqKey="Johnson A" first="Andrew D." last="Johnson">Andrew D. Johnson</name><name sortKey="Kao, W H Linda" sort="Kao, W H Linda" uniqKey="Kao W" first="W. H. Linda" last="Kao">W. H. Linda Kao</name><name sortKey="Kao, W H Linda" sort="Kao, W H Linda" uniqKey="Kao W" first="W. H. Linda" last="Kao">W. H. Linda Kao</name><name sortKey="Kardia, Sharon L R" sort="Kardia, Sharon L R" uniqKey="Kardia S" first="Sharon L. R." last="Kardia">Sharon L. R. Kardia</name><name sortKey="Katz, Ronit" sort="Katz, Ronit" uniqKey="Katz R" first="Ronit" last="Katz">Ronit Katz</name><name sortKey="Keene, Keith L" sort="Keene, Keith L" uniqKey="Keene K" first="Keith L." last="Keene">Keith L. Keene</name><name sortKey="Ko, Yi An" sort="Ko, Yi An" uniqKey="Ko Y" first="Yi-An" last="Ko">Yi-An Ko</name><name sortKey="Kottgen, Anna" sort="Kottgen, Anna" uniqKey="Kottgen A" first="Anna" last="Köttgen">Anna Köttgen</name><name sortKey="Kramer, Holly" sort="Kramer, Holly" uniqKey="Kramer H" first="Holly" last="Kramer">Holly Kramer</name><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name><name sortKey="Li, Guo" sort="Li, Guo" uniqKey="Li G" first="Guo" last="Li">Guo Li</name><name sortKey="Li, Man" sort="Li, Man" uniqKey="Li M" first="Man" last="Li">Man Li</name><name sortKey="Lin, Honghuang" sort="Lin, Honghuang" uniqKey="Lin H" first="Honghuang" last="Lin">Honghuang Lin</name><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name><name sortKey="Lohman, Kurt" sort="Lohman, Kurt" uniqKey="Lohman K" first="Kurt" last="Lohman">Kurt Lohman</name><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J. F." last="Loos">Ruth J. F. Loos</name><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J. F." last="Loos">Ruth J. F. Loos</name><name sortKey="Lu, Yingchang" sort="Lu, Yingchang" uniqKey="Lu Y" first="Yingchang" last="Lu">Yingchang Lu</name><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name><name sortKey="Morrison, Alanna C" sort="Morrison, Alanna C" uniqKey="Morrison A" first="Alanna C." last="Morrison">Alanna C. Morrison</name><name sortKey="Muntner, Paul" sort="Muntner, Paul" uniqKey="Muntner P" first="Paul" last="Muntner">Paul Muntner</name><name sortKey="Muntner, Paul" sort="Muntner, Paul" uniqKey="Muntner P" first="Paul" last="Muntner">Paul Muntner</name><name sortKey="Nalls, Michael" sort="Nalls, Michael" uniqKey="Nalls M" first="Michael" last="Nalls">Michael Nalls</name><name sortKey="O Connell, Jeffrey R" sort="O Connell, Jeffrey R" uniqKey="O Connell J" first="Jeffrey R." last="O'Connell">Jeffrey R. O'Connell</name><name sortKey="Parsa, Afshin" sort="Parsa, Afshin" uniqKey="Parsa A" first="Afshin" last="Parsa">Afshin Parsa</name><name sortKey="Peralta, Carmen A" sort="Peralta, Carmen A" uniqKey="Peralta C" first="Carmen A." last="Peralta">Carmen A. Peralta</name><name sortKey="Pers, Tune H" sort="Pers, Tune H" uniqKey="Pers T" first="Tune H." last="Pers">Tune H. Pers</name><name sortKey="Pers, Tune H" sort="Pers, Tune H" uniqKey="Pers T" first="Tune H." last="Pers">Tune H. Pers</name><name sortKey="Rao, Madhumathi" sort="Rao, Madhumathi" uniqKey="Rao M" first="Madhumathi" last="Rao">Madhumathi Rao</name><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M." last="Ridker">Paul M. Ridker</name><name sortKey="Rosas, Sylvia E" sort="Rosas, Sylvia E" uniqKey="Rosas S" first="Sylvia E." last="Rosas">Sylvia E. Rosas</name><name sortKey="Rose, Lynda M" sort="Rose, Lynda M" uniqKey="Rose L" first="Lynda M." last="Rose">Lynda M. Rose</name><name sortKey="Rotimi, Charles N" sort="Rotimi, Charles N" uniqKey="Rotimi C" first="Charles N." last="Rotimi">Charles N. Rotimi</name><name sortKey="Ruderfer, Douglas" sort="Ruderfer, Douglas" uniqKey="Ruderfer D" first="Douglas" last="Ruderfer">Douglas Ruderfer</name><name sortKey="Sale, Michele M" sort="Sale, Michele M" uniqKey="Sale M" first="Michele M." last="Sale">Michele M. Sale</name><name sortKey="Shaffer, Christian M" sort="Shaffer, Christian M" uniqKey="Shaffer C" first="Christian M." last="Shaffer">Christian M. Shaffer</name><name sortKey="Shriner, Daniel" sort="Shriner, Daniel" uniqKey="Shriner D" first="Daniel" last="Shriner">Daniel Shriner</name><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R." last="Shuldiner">Alan R. Shuldiner</name><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R." last="Shuldiner">Alan R. Shuldiner</name><name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S." last="Siscovick">David S. Siscovick</name><name sortKey="Smith, Jennifer A" sort="Smith, Jennifer A" uniqKey="Smith J" first="Jennifer A." last="Smith">Jennifer A. Smith</name><name sortKey="Stafford, Jeanette M" sort="Stafford, Jeanette M" uniqKey="Stafford J" first="Jeanette M." last="Stafford">Jeanette M. Stafford</name><name sortKey="Susztak, Katalin" sort="Susztak, Katalin" uniqKey="Susztak K" first="Katalin" last="Susztak">Katalin Susztak</name><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name><name sortKey="Tayo, Bamidele" sort="Tayo, Bamidele" uniqKey="Tayo B" first="Bamidele" last="Tayo">Bamidele Tayo</name><name sortKey="Tin, Adrienne" sort="Tin, Adrienne" uniqKey="Tin A" first="Adrienne" last="Tin">Adrienne Tin</name><name sortKey="Turner, Stephen T" sort="Turner, Stephen T" uniqKey="Turner S" first="Stephen T." last="Turner">Stephen T. Turner</name><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name><name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name><name sortKey="Zonderman, Alan B" sort="Zonderman, Alan B" uniqKey="Zonderman A" first="Alan B." last="Zonderman">Alan B. Zonderman</name></country><country name="Pays-Bas"><noRegion><name sortKey="Isaacs, Aaron" sort="Isaacs, Aaron" uniqKey="Isaacs A" first="Aaron" last="Isaacs">Aaron Isaacs</name></noRegion><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name><name sortKey="Demirkan, Ayse" sort="Demirkan, Ayse" uniqKey="Demirkan A" first="Ayse" last="Demirkan">Ayse Demirkan</name><name sortKey="Felix, Janine F" sort="Felix, Janine F" uniqKey="Felix J" first="Janine F." last="Felix">Janine F. Felix</name><name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H." last="Franco">Oscar H. Franco</name><name sortKey="Franke, Lude" sort="Franke, Lude" uniqKey="Franke L" first="Lude" last="Franke">Lude Franke</name><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><name sortKey="Isaacs, Aaron" sort="Isaacs, Aaron" uniqKey="Isaacs A" first="Aaron" last="Isaacs">Aaron Isaacs</name><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name><name sortKey="Karjalainen, Juha" sort="Karjalainen, Juha" uniqKey="Karjalainen J" first="Juha" last="Karjalainen">Juha Karjalainen</name><name sortKey="Leach, I Mateo" sort="Leach, I Mateo" uniqKey="Leach I" first="I. Mateo" last="Leach">I. Mateo Leach</name><name sortKey="Navis, Gerjan J" sort="Navis, Gerjan J" uniqKey="Navis G" first="Gerjan J." last="Navis">Gerjan J. Navis</name><name sortKey="Nolte, Ilja M" sort="Nolte, Ilja M" uniqKey="Nolte I" first="Ilja M." last="Nolte">Ilja M. Nolte</name><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name><name sortKey="Penninx, Brenda W" sort="Penninx, Brenda W" uniqKey="Penninx B" first="Brenda W." last="Penninx">Brenda W. Penninx</name><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><name sortKey="Sedaghat, Sanaz" sort="Sedaghat, Sanaz" uniqKey="Sedaghat S" first="Sanaz" last="Sedaghat">Sanaz Sedaghat</name><name sortKey="Smit, Johannes H" sort="Smit, Johannes H" uniqKey="Smit J" first="Johannes H." last="Smit">Johannes H. Smit</name><name sortKey="Snieder, Harold" sort="Snieder, Harold" uniqKey="Snieder H" first="Harold" last="Snieder">Harold Snieder</name><name sortKey="Struchalin, Maksim" sort="Struchalin, Maksim" uniqKey="Struchalin M" first="Maksim" last="Struchalin">Maksim Struchalin</name><name sortKey="Struchalin, Maksim" sort="Struchalin, Maksim" uniqKey="Struchalin M" first="Maksim" last="Struchalin">Maksim Struchalin</name><name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><name sortKey="Van Der Most, Peter J" sort="Van Der Most, Peter J" uniqKey="Van Der Most P" first="Peter J." last="Van Der Most">Peter J. Van Der Most</name><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><name sortKey="Verweij, Niek" sort="Verweij, Niek" uniqKey="Verweij N" first="Niek" last="Verweij">Niek Verweij</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F." last="Wright">Alan F. Wright</name></noRegion><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name><name sortKey="Hastie, Nick" sort="Hastie, Nick" uniqKey="Hastie N" first="Nick" last="Hastie">Nick Hastie</name><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><name sortKey="Munroe, Patricia B" sort="Munroe, Patricia B" uniqKey="Munroe P" first="Patricia B." last="Munroe">Patricia B. 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