Immuno-psychiatry: an agenda for clinical practice and innovative research
Identifieur interne : 000855 ( Pmc/Checkpoint ); précédent : 000854; suivant : 000856Immuno-psychiatry: an agenda for clinical practice and innovative research
Auteurs : Marion Leboyer [France] ; Michael Berk [Australie] ; Robert H. Yolken [États-Unis] ; Ryad Tamouza [France] ; David Kupfer [États-Unis] ; Laurent Groc [France]Source :
- BMC Medicine [ 1741-7015 ] ; 2016.
Abstract
The diagnostic scheme for psychiatric disorders is currently based purely on descriptive nomenclature given that biomarkers subtypes and clearly defined causal mechanisms are lacking for the vast majority of disorders. The emerging field of “immuno-psychiatry” has the potential to widen the exploration of a mechanism-based nosology, possibly leading to the discovery of more effective personalised treatment strategies.
Disturbances in immuno-inflammatory and related systems have been implicated in the aetiology, pathophysiology, phenomenology and comorbidity of several psychiatric disorders, including major mood disorders and schizophrenia. A fundamental challenge in their clinical management is to identify bio-signatures that might indicate risk, state, trait, prognosis or theragnosis. Here, we provide the rationale for a clinical and research agenda to refine future clinical practice and conceptual views, and to delineate pathways toward innovative treatment discovery.
The development of bio-signatures will allow clinicians to tailor interventions to the abovementioned biomarker subtypes – a major translational goal for research in this field.
Url:
DOI: 10.1186/s12916-016-0712-5
PubMed: 27788673
PubMed Central: 5084344
Affiliations:
- Australie, France, États-Unis
- Maryland, Pennsylvanie, Victoria (État), Île-de-France
- Baltimore, Créteil, Melbourne, Paris
- Université de Melbourne
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>The diagnostic scheme for psychiatric disorders is currently based purely on descriptive nomenclature given that biomarkers subtypes and clearly defined causal mechanisms are lacking for the vast majority of disorders. The emerging field of “immuno-psychiatry” has the potential to widen the exploration of a mechanism-based nosology, possibly leading to the discovery of more effective personalised treatment strategies.</p>
</sec>
<sec><title>Discussion</title>
<p>Disturbances in immuno-inflammatory and related systems have been implicated in the aetiology, pathophysiology, phenomenology and comorbidity of several psychiatric disorders, including major mood disorders and schizophrenia. A fundamental challenge in their clinical management is to identify bio-signatures that might indicate risk, state, trait, prognosis or theragnosis. Here, we provide the rationale for a clinical and research agenda to refine future clinical practice and conceptual views, and to delineate pathways toward innovative treatment discovery.</p>
</sec>
<sec><title>Conclusion</title>
<p>The development of bio-signatures will allow clinicians to tailor interventions to the abovementioned biomarker subtypes – a major translational goal for research in this field.</p>
</sec>
</div>
</front>
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<pmc article-type="editorial"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Med</journal-id>
<journal-id journal-id-type="iso-abbrev">BMC Med</journal-id>
<journal-title-group><journal-title>BMC Medicine</journal-title>
</journal-title-group>
<issn pub-type="epub">1741-7015</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
<publisher-loc>London</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">27788673</article-id>
<article-id pub-id-type="pmc">5084344</article-id>
<article-id pub-id-type="publisher-id">712</article-id>
<article-id pub-id-type="doi">10.1186/s12916-016-0712-5</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Opinion</subject>
</subj-group>
</article-categories>
<title-group><article-title>Immuno-psychiatry: an agenda for clinical practice and innovative research</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Leboyer</surname>
<given-names>Marion</given-names>
</name>
<address><email>marion.leboyer@inserm.fr</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff2">2</xref>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Berk</surname>
<given-names>Michael</given-names>
</name>
<xref ref-type="aff" rid="Aff4">4</xref>
<xref ref-type="aff" rid="Aff5">5</xref>
<xref ref-type="aff" rid="Aff6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yolken</surname>
<given-names>Robert H.</given-names>
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<xref ref-type="aff" rid="Aff7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tamouza</surname>
<given-names>Ryad</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
<xref ref-type="aff" rid="Aff8">8</xref>
<xref ref-type="aff" rid="Aff9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kupfer</surname>
<given-names>David</given-names>
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<xref ref-type="aff" rid="Aff10">10</xref>
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<contrib contrib-type="author" corresp="yes"><name><surname>Groc</surname>
<given-names>Laurent</given-names>
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<address><email>laurent.groc@u-bordeaux.fr</email>
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<xref ref-type="aff" rid="Aff2">2</xref>
<xref ref-type="aff" rid="Aff3">3</xref>
<xref ref-type="aff" rid="Aff11">11</xref>
</contrib>
<aff id="Aff1"><label>1</label>
Psychiatry Department, University Paris-Est-Créteil, Mondor hospital, AP-HP, DHU PePSY, Translational Psychiatry laboratory, INSERM U955, Paris, France</aff>
<aff id="Aff2"><label>2</label>
Fondation FondaMental, Creteil, France</aff>
<aff id="Aff3"><label>3</label>
University of Bordeaux, UMR 5297, 33000 Bordeaux, France</aff>
<aff id="Aff4"><label>4</label>
Deakin University, IMPACT Strategic Research Centre (Barwon Health), School of Medicine, Geelong, VIC Australia</aff>
<aff id="Aff5"><label>5</label>
The Florey Institute of Neuroscience and Mental Health, Orygen, National Centre of Excellence for Youth Mental Health, Parkville, VIC Australia</aff>
<aff id="Aff6"><label>6</label>
Department of Psychiatry, University of Melbourne, Royal Melbourne Hospital, Parkville, VIC Australia</aff>
<aff id="Aff7"><label>7</label>
Stanley Division of Developmental Neurovirology, The Johns Hopkins University School of Medicine, Baltimore, USA</aff>
<aff id="Aff8"><label>8</label>
INSERM, U1160, Hôpital Saint Louis, Paris, F75010 France</aff>
<aff id="Aff9"><label>9</label>
Laboratoire Jean Dausset, LabexTransplantex, Hôpital Saint Louis, Paris, F75010 France</aff>
<aff id="Aff10"><label>10</label>
Departments of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA USA</aff>
<aff id="Aff11"><label>11</label>
Interdisciplinary Institute for Neuroscience, CNRS UMR 5297, 33077 Bordeaux, France</aff>
</contrib-group>
<pub-date pub-type="epub"><day>28</day>
<month>10</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>28</day>
<month>10</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="collection"><year>2016</year>
</pub-date>
<volume>14</volume>
<elocation-id>173</elocation-id>
<history><date date-type="received"><day>6</day>
<month>8</month>
<year>2016</year>
</date>
<date date-type="accepted"><day>4</day>
<month>10</month>
<year>2016</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s). 2016</copyright-statement>
<license license-type="OpenAccess"><license-p><bold>Open Access</bold>
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>
) applies to the data made available in this article, unless otherwise stated.</license-p>
</license>
</permissions>
<abstract id="Abs1"><sec><title>Background</title>
<p>The diagnostic scheme for psychiatric disorders is currently based purely on descriptive nomenclature given that biomarkers subtypes and clearly defined causal mechanisms are lacking for the vast majority of disorders. The emerging field of “immuno-psychiatry” has the potential to widen the exploration of a mechanism-based nosology, possibly leading to the discovery of more effective personalised treatment strategies.</p>
</sec>
<sec><title>Discussion</title>
<p>Disturbances in immuno-inflammatory and related systems have been implicated in the aetiology, pathophysiology, phenomenology and comorbidity of several psychiatric disorders, including major mood disorders and schizophrenia. A fundamental challenge in their clinical management is to identify bio-signatures that might indicate risk, state, trait, prognosis or theragnosis. Here, we provide the rationale for a clinical and research agenda to refine future clinical practice and conceptual views, and to delineate pathways toward innovative treatment discovery.</p>
</sec>
<sec><title>Conclusion</title>
<p>The development of bio-signatures will allow clinicians to tailor interventions to the abovementioned biomarker subtypes – a major translational goal for research in this field.</p>
</sec>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>Personalised psychiatry</kwd>
<kwd>Immune inflammation</kwd>
<kwd>Biomarkers</kwd>
<kwd>Biological pathways</kwd>
<kwd>Translational research</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2016</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Australie</li>
<li>France</li>
<li>États-Unis</li>
</country>
<region><li>Maryland</li>
<li>Pennsylvanie</li>
<li>Victoria (État)</li>
<li>Île-de-France</li>
</region>
<settlement><li>Baltimore</li>
<li>Créteil</li>
<li>Melbourne</li>
<li>Paris</li>
</settlement>
<orgName><li>Université de Melbourne</li>
</orgName>
</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Leboyer, Marion" sort="Leboyer, Marion" uniqKey="Leboyer M" first="Marion" last="Leboyer">Marion Leboyer</name>
</region>
<name sortKey="Groc, Laurent" sort="Groc, Laurent" uniqKey="Groc L" first="Laurent" last="Groc">Laurent Groc</name>
<name sortKey="Groc, Laurent" sort="Groc, Laurent" uniqKey="Groc L" first="Laurent" last="Groc">Laurent Groc</name>
<name sortKey="Groc, Laurent" sort="Groc, Laurent" uniqKey="Groc L" first="Laurent" last="Groc">Laurent Groc</name>
<name sortKey="Leboyer, Marion" sort="Leboyer, Marion" uniqKey="Leboyer M" first="Marion" last="Leboyer">Marion Leboyer</name>
<name sortKey="Leboyer, Marion" sort="Leboyer, Marion" uniqKey="Leboyer M" first="Marion" last="Leboyer">Marion Leboyer</name>
<name sortKey="Tamouza, Ryad" sort="Tamouza, Ryad" uniqKey="Tamouza R" first="Ryad" last="Tamouza">Ryad Tamouza</name>
</country>
<country name="Australie"><region name="Victoria (État)"><name sortKey="Berk, Michael" sort="Berk, Michael" uniqKey="Berk M" first="Michael" last="Berk">Michael Berk</name>
</region>
</country>
<country name="États-Unis"><region name="Maryland"><name sortKey="Yolken, Robert H" sort="Yolken, Robert H" uniqKey="Yolken R" first="Robert H." last="Yolken">Robert H. Yolken</name>
</region>
<name sortKey="Kupfer, David" sort="Kupfer, David" uniqKey="Kupfer D" first="David" last="Kupfer">David Kupfer</name>
</country>
</tree>
</affiliations>
</record>
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