Neutrophil-derived microparticles are released into the coronary circulation following percutaneous coronary intervention in acute coronary syndrome patients
Identifieur interne : 000183 ( Pmc/Checkpoint ); précédent : 000182; suivant : 000184Neutrophil-derived microparticles are released into the coronary circulation following percutaneous coronary intervention in acute coronary syndrome patients
Auteurs : Gonzalo J. Martínez [Australie, Chili] ; Jennifer Y. Barraclough [Australie] ; Shirley Nakhla [Australie] ; Vivian Kienzle [Australie] ; Stacy Robertson [Australie] ; Ziad Mallat [France, Royaume-Uni] ; David S. Celermajer [Australie] ; Sanjay Patel [Australie]Source :
- Bioscience Reports [ 0144-8463 ] ; 2017.
Abstract
To evaluate (i) local coronary and systemic levels of microparticles (MP) in acute coronary syndrome (ACS) and stable angina pectoris (SAP) patients and (ii) their release after plaque disruption with percutaneous coronary intervention (PCI). MP are small vesicles originating from plasma membranes of cells after activation or apoptosis and are implicated in the pathogenesis of atherosclerosis. Neutrophils play a role in plaque destabilization and shed neutrophil-derived MP that have the potential to drive significant proinflammatory and thrombotic downstream effects. Eight ACS and eight SAP patients were included. Coronary sinus (CS) samples pre-intervention (CS1), 45 s following balloon angioplasty (CS2) and at 45 s intervals following stent deployment (CS3, CS4 and CS5), together with peripheral vein samples, pre- and post-PCI were analysed for neutrophil-derived (CD66b+), endothelial-derived (CD144+), platelet-derived (CD41a+), monocyte-derived (CD14+) and apoptotic (Annexin V+) MP. ELISA for interleukin (IL)-6, myeloperoxidase (MPO) and P-selectin was also performed. CD66b+ MP levels were similar in both groups pre-intervention. Post-PCI, CS levels rose significantly in ACS but not SAP patients (ACS area under the curve (AUC): 549 ± 83, SAP AUC: 24 ± 29,
Url:
DOI: 10.1042/BSR20160430
PubMed: 27913753
PubMed Central: 5240586
Affiliations:
- Australie, Chili, France, Royaume-Uni
- Angleterre, Angleterre de l'Est, Nouvelle-Galles du Sud, Île-de-France
- Cambridge, Paris, Sydney
- Université de Cambridge, Université de Sydney
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Martínez</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Sydney Medical School, The University of Sydney, New South Wales, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, The University of Sydney, New South Wales</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">División de Enfermedades Cardiovasculares, Pontificia Universidad Católica de Chile, Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>División de Enfermedades Cardiovasculares, Pontificia Universidad Católica de Chile, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Barraclough, Jennifer Y" sort="Barraclough, Jennifer Y" uniqKey="Barraclough J" first="Jennifer Y." last="Barraclough">Jennifer Y. Barraclough</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Sydney Medical School, The University of Sydney, New South Wales, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, The University of Sydney, New South Wales</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Heart Research Institute, Sydney, New South Wales, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Heart Research Institute, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Nakhla, Shirley" sort="Nakhla, Shirley" uniqKey="Nakhla S" first="Shirley" last="Nakhla">Shirley Nakhla</name><affiliation wicri:level="1"><nlm:aff id="A4">Heart Research Institute, Sydney, New South Wales, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Heart Research Institute, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Kienzle, Vivian" sort="Kienzle, Vivian" uniqKey="Kienzle V" first="Vivian" last="Kienzle">Vivian Kienzle</name><affiliation wicri:level="1"><nlm:aff id="A4">Heart Research Institute, Sydney, New South Wales, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Heart Research Institute, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Robertson, Stacy" sort="Robertson, Stacy" uniqKey="Robertson S" first="Stacy" last="Robertson">Stacy Robertson</name><affiliation wicri:level="4"><nlm:aff id="A2">Sydney Medical School, The University of Sydney, New South Wales, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, The University of Sydney, New South Wales</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Heart Research Institute, Sydney, New South Wales, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Heart Research Institute, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Mallat, Ziad" sort="Mallat, Ziad" uniqKey="Mallat Z" first="Ziad" last="Mallat">Ziad Mallat</name><affiliation wicri:level="3"><nlm:aff id="A5">Institut National de la Santé et de la Recherche Médicale (INSERM), Paris Cardiovascular Research Center, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale (INSERM), Paris Cardiovascular Research Center, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A6">Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke’s Hospital, Cambridge, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke’s Hospital, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Celermajer, David S" sort="Celermajer, David S" uniqKey="Celermajer D" first="David S." last="Celermajer">David S. Celermajer</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Sydney Medical School, The University of Sydney, New South Wales, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, The University of Sydney, New South Wales</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Heart Research Institute, Sydney, New South Wales, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Heart Research Institute, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Patel, Sanjay" sort="Patel, Sanjay" uniqKey="Patel S" first="Sanjay" last="Patel">Sanjay Patel</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Sydney Medical School, The University of Sydney, New South Wales, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, The University of Sydney, New South Wales</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Heart Research Institute, Sydney, New South Wales, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Heart Research Institute, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author></analytic><series><title level="j">Bioscience Reports</title><idno type="ISSN">0144-8463</idno><idno type="eISSN">1573-4935</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>To evaluate (i) local coronary and systemic levels of microparticles (MP) in acute coronary syndrome (ACS) and stable angina pectoris (SAP) patients and (ii) their release after plaque disruption with percutaneous coronary intervention (PCI). MP are small vesicles originating from plasma membranes of cells after activation or apoptosis and are implicated in the pathogenesis of atherosclerosis. Neutrophils play a role in plaque destabilization and shed neutrophil-derived MP that have the potential to drive significant proinflammatory and thrombotic downstream effects. Eight ACS and eight SAP patients were included. Coronary sinus (CS) samples pre-intervention (CS1), 45 s following balloon angioplasty (CS2) and at 45 s intervals following stent deployment (CS3, CS4 and CS5), together with peripheral vein samples, pre- and post-PCI were analysed for neutrophil-derived (CD66b+), endothelial-derived (CD144+), platelet-derived (CD41a+), monocyte-derived (CD14+) and apoptotic (Annexin V+) MP. ELISA for interleukin (IL)-6, myeloperoxidase (MPO) and P-selectin was also performed. CD66b+ MP levels were similar in both groups pre-intervention. Post-PCI, CS levels rose significantly in ACS but not SAP patients (ACS area under the curve (AUC): 549 ± 83, SAP AUC: 24 ± 29, <italic>P</italic><0.01). CS CD41a+, CD144+, CD14+ and Annexin V+ MP levels did not differ between groups. Acute neutrophil-derived MP release post-PCI occurs in ACS compared with stable patients, likely to be reflective of plaque MP content in vulnerable lesions.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Angelillo Scherrer, A" uniqKey="Angelillo Scherrer A">A. Angelillo-Scherrer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chironi, G" uniqKey="Chironi G">G. Chironi</name></author><author><name sortKey="Simon, A" uniqKey="Simon A">A. Simon</name></author><author><name sortKey="Hugel, B" uniqKey="Hugel B">B. Hugel</name></author><author><name sortKey="Del Pino, M" uniqKey="Del Pino M">M. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Biosci Rep</journal-id><journal-id journal-id-type="iso-abbrev">Biosci. Rep</journal-id><journal-id journal-id-type="hwp">ppbioscirep</journal-id><journal-id journal-id-type="publisher-id">BSR</journal-id><journal-title-group><journal-title>Bioscience Reports</journal-title></journal-title-group><issn pub-type="ppub">0144-8463</issn><issn pub-type="epub">1573-4935</issn><publisher><publisher-name>Portland Press Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27913753</article-id><article-id pub-id-type="pmc">5240586</article-id><article-id pub-id-type="doi">10.1042/BSR20160430</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Articles</subject></subj-group><subj-group subj-group-type="overline"><subject>Research Article</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>40</subject></subj-group></article-categories><title-group><article-title>Neutrophil-derived microparticles are released into the coronary circulation following percutaneous coronary intervention in acute coronary syndrome patients</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Martínez</surname><given-names>Gonzalo J.</given-names></name><xref ref-type="aff" rid="A1"><sup>1</sup></xref><xref ref-type="aff" rid="A2"><sup>2</sup></xref><xref ref-type="aff" rid="A3"><sup>3</sup></xref><xref ref-type="author-notes" rid="afn1">*</xref></contrib><contrib contrib-type="author"><name><surname>Barraclough</surname><given-names>Jennifer Y.</given-names></name><xref ref-type="aff" rid="A1"><sup>1</sup></xref><xref ref-type="aff" rid="A2"><sup>2</sup></xref><xref ref-type="aff" rid="A4"><sup>4</sup></xref><xref ref-type="author-notes" rid="afn1">*</xref></contrib><contrib contrib-type="author"><name><surname>Nakhla</surname><given-names>Shirley</given-names></name><xref ref-type="aff" rid="A4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kienzle</surname><given-names>Vivian</given-names></name><xref ref-type="aff" rid="A4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Robertson</surname><given-names>Stacy</given-names></name><xref ref-type="aff" rid="A2"><sup>2</sup></xref><xref ref-type="aff" rid="A4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mallat</surname><given-names>Ziad</given-names></name><xref ref-type="aff" rid="A5"><sup>5</sup></xref><xref ref-type="aff" rid="A6"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Celermajer</surname><given-names>David S.</given-names></name><xref ref-type="aff" rid="A1"><sup>1</sup></xref><xref ref-type="aff" rid="A2"><sup>2</sup></xref><xref ref-type="aff" rid="A4"><sup>4</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Patel</surname><given-names>Sanjay</given-names></name><xref ref-type="corresp" rid="COR1"></xref><xref ref-type="aff" rid="A1"><sup>1</sup></xref><xref ref-type="aff" rid="A2"><sup>2</sup></xref><xref ref-type="aff" rid="A4"><sup>4</sup></xref></contrib><aff id="A1"><label>1</label>Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia</aff><aff id="A2"><label>2</label>Sydney Medical School, The University of Sydney, New South Wales, Australia</aff><aff id="A3"><label>3</label>División de Enfermedades Cardiovasculares, Pontificia Universidad Católica de Chile, Santiago, Chile</aff><aff id="A4"><label>4</label>Heart Research Institute, Sydney, New South Wales, Australia</aff><aff id="A5"><label>5</label>Institut National de la Santé et de la Recherche Médicale (INSERM), Paris Cardiovascular Research Center, Paris, France</aff><aff id="A6"><label>6</label>Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke’s Hospital, Cambridge, United Kingdom</aff></contrib-group><author-notes><corresp id="COR1"><bold>Correspondence:</bold> Sanjay Patel (<email>sanjay.patel@hri.org.au</email>)</corresp><fn id="afn1" fn-type="equal"><label>*</label><p>These authors contributed equally to this work.</p></fn></author-notes><pub-date pub-type="epreprint"><day>02</day><month>12</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>17</day><month>1</month><year>2017</year></pub-date><pub-date pub-type="collection"><day>28</day><month>2</month><year>2017</year></pub-date><volume>37</volume><issue>1</issue><elocation-id>BSR20160430</elocation-id><history><date date-type="received"><day>10</day><month>8</month><year>2016</year></date><date date-type="rev-recd"><day>20</day><month>11</month><year>2016</year></date><date date-type="accepted"><day>01</day><month>12</month><year>2016</year></date></history><permissions><copyright-statement>© 2017 The Author(s)</copyright-statement><copyright-year>2017</copyright-year><license license-type="open-access"><ali:license_ref>http://creativecommons.org/licenses/by/4.0/</ali:license_ref><license-p>This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License 4.0 (CC BY)</ext-link>.</license-p></license></permissions><self-uri xlink:title="pdf" xlink:href="BSR-2016-0430-T.pdf"></self-uri><abstract><p>To evaluate (i) local coronary and systemic levels of microparticles (MP) in acute coronary syndrome (ACS) and stable angina pectoris (SAP) patients and (ii) their release after plaque disruption with percutaneous coronary intervention (PCI). MP are small vesicles originating from plasma membranes of cells after activation or apoptosis and are implicated in the pathogenesis of atherosclerosis. Neutrophils play a role in plaque destabilization and shed neutrophil-derived MP that have the potential to drive significant proinflammatory and thrombotic downstream effects. Eight ACS and eight SAP patients were included. Coronary sinus (CS) samples pre-intervention (CS1), 45 s following balloon angioplasty (CS2) and at 45 s intervals following stent deployment (CS3, CS4 and CS5), together with peripheral vein samples, pre- and post-PCI were analysed for neutrophil-derived (CD66b+), endothelial-derived (CD144+), platelet-derived (CD41a+), monocyte-derived (CD14+) and apoptotic (Annexin V+) MP. ELISA for interleukin (IL)-6, myeloperoxidase (MPO) and P-selectin was also performed. CD66b+ MP levels were similar in both groups pre-intervention. Post-PCI, CS levels rose significantly in ACS but not SAP patients (ACS area under the curve (AUC): 549 ± 83, SAP AUC: 24 ± 29, <italic>P</italic><0.01). CS CD41a+, CD144+, CD14+ and Annexin V+ MP levels did not differ between groups. Acute neutrophil-derived MP release post-PCI occurs in ACS compared with stable patients, likely to be reflective of plaque MP content in vulnerable lesions.</p></abstract><kwd-group><kwd>Microparticles</kwd><kwd>Neutrophils</kwd><kwd>Acute Coronary Syndromes</kwd></kwd-group><counts><page-count count="12"></page-count></counts></article-meta></front></pmc><affiliations><list><country><li>Australie</li><li>Chili</li><li>France</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Nouvelle-Galles du Sud</li><li>Île-de-France</li></region><settlement><li>Cambridge</li><li>Paris</li><li>Sydney</li></settlement><orgName><li>Université de Cambridge</li><li>Université de Sydney</li></orgName></list><tree><country name="Australie"><noRegion><name sortKey="Martinez, Gonzalo J" sort="Martinez, Gonzalo J" uniqKey="Martinez G" first="Gonzalo J." last="Martínez">Gonzalo J. Martínez</name></noRegion><name sortKey="Barraclough, Jennifer Y" sort="Barraclough, Jennifer Y" uniqKey="Barraclough J" first="Jennifer Y." last="Barraclough">Jennifer Y. Barraclough</name><name sortKey="Barraclough, Jennifer Y" sort="Barraclough, Jennifer Y" uniqKey="Barraclough J" first="Jennifer Y." last="Barraclough">Jennifer Y. Barraclough</name><name sortKey="Barraclough, Jennifer Y" sort="Barraclough, Jennifer Y" uniqKey="Barraclough J" first="Jennifer Y." last="Barraclough">Jennifer Y. Barraclough</name><name sortKey="Celermajer, David S" sort="Celermajer, David S" uniqKey="Celermajer D" first="David S." last="Celermajer">David S. Celermajer</name><name sortKey="Celermajer, David S" sort="Celermajer, David S" uniqKey="Celermajer D" first="David S." last="Celermajer">David S. Celermajer</name><name sortKey="Celermajer, David S" sort="Celermajer, David S" uniqKey="Celermajer D" first="David S." last="Celermajer">David S. Celermajer</name><name sortKey="Kienzle, Vivian" sort="Kienzle, Vivian" uniqKey="Kienzle V" first="Vivian" last="Kienzle">Vivian Kienzle</name><name sortKey="Martinez, Gonzalo J" sort="Martinez, Gonzalo J" uniqKey="Martinez G" first="Gonzalo J." last="Martínez">Gonzalo J. Martínez</name><name sortKey="Nakhla, Shirley" sort="Nakhla, Shirley" uniqKey="Nakhla S" first="Shirley" last="Nakhla">Shirley Nakhla</name><name sortKey="Patel, Sanjay" sort="Patel, Sanjay" uniqKey="Patel S" first="Sanjay" last="Patel">Sanjay Patel</name><name sortKey="Patel, Sanjay" sort="Patel, Sanjay" uniqKey="Patel S" first="Sanjay" last="Patel">Sanjay Patel</name><name sortKey="Patel, Sanjay" sort="Patel, Sanjay" uniqKey="Patel S" first="Sanjay" last="Patel">Sanjay Patel</name><name sortKey="Robertson, Stacy" sort="Robertson, Stacy" uniqKey="Robertson S" first="Stacy" last="Robertson">Stacy Robertson</name><name sortKey="Robertson, Stacy" sort="Robertson, Stacy" uniqKey="Robertson S" first="Stacy" last="Robertson">Stacy Robertson</name></country><country name="Chili"><noRegion><name sortKey="Martinez, Gonzalo J" sort="Martinez, Gonzalo J" uniqKey="Martinez G" first="Gonzalo J." last="Martínez">Gonzalo J. Martínez</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Mallat, Ziad" sort="Mallat, Ziad" uniqKey="Mallat Z" first="Ziad" last="Mallat">Ziad Mallat</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Mallat, Ziad" sort="Mallat, Ziad" uniqKey="Mallat Z" first="Ziad" last="Mallat">Ziad Mallat</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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