SIRT1 activation mediates heat-induced survival of UVB damaged Keratinocytes
Identifieur interne : 000099 ( Pmc/Checkpoint ); précédent : 000098; suivant : 000100SIRT1 activation mediates heat-induced survival of UVB damaged Keratinocytes
Auteurs : Leslie Calapre ; Elin S. Gray ; Sandrine Kurdykowski [France] ; Anthony David [France] ; Pascal Descargues [France] ; Mel ZimanSource :
- BMC Dermatology [ 1471-5945 ] ; 2017.
Abstract
Exposure to heat stress after UVB irradiation induces a reduction of apoptosis, resulting in survival of DNA damaged human keratinocytes. This heat-mediated evasion of apoptosis appears to be mediated by activation of SIRT1 and inactivation of p53 signalling. In this study, we assessed the role of SIRT1 in the inactivation of p53 signalling and impairment of DNA damage response in UVB
Activation of SIRT1 after multiple UVB
This study demonstrate that heat-induced SIRT1 activation mediates survival of DNA damaged keratinocytes through deacetylation of p53 after exposure to UVB
The online version of this article (doi:10.1186/s12895-017-0060-y) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s12895-017-0060-y
PubMed: 28601088
PubMed Central: 5466784
Affiliations:
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">SIRT1 activation mediates heat-induced survival of UVB damaged Keratinocytes</title>
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<series><title level="j">BMC Dermatology</title>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Exposure to heat stress after UVB irradiation induces a reduction of apoptosis, resulting in survival of DNA damaged human keratinocytes. This heat-mediated evasion of apoptosis appears to be mediated by activation of SIRT1 and inactivation of p53 signalling. In this study, we assessed the role of SIRT1 in the inactivation of p53 signalling and impairment of DNA damage response in UVB <italic>plus</italic>
heat exposed keratinocytes.</p>
</sec>
<sec><title>Results</title>
<p>Activation of SIRT1 after multiple UVB <italic>plus</italic>
heat exposures resulted in increased p53 deacetylation at K382, which is known to affect its binding to specific target genes. Accordingly, we noted decreased apoptosis and down regulation of the p53 targeted pro-apoptotic gene <italic>BAX</italic>
and the DNA repair genes <italic>ERCC1</italic>
and <italic>XPC</italic>
after UVB <italic>plus</italic>
heat treatments. In addition, UVB <italic>plus</italic>
heat induced increased expression of the cell survival gene <italic>Survivin</italic>
and the proliferation marker Ki67. Notably, keratinocytes exposed to UVB <italic>plus</italic>
heat in the presence of the SIRT1 inhibitor, Ex-527, showed a similar phenotype to those exposed to UV alone; i.e. an increase in p53 acetylation, increased apoptosis and low levels of <italic>Survivin</italic>
.</p>
</sec>
<sec><title>Conclusion</title>
<p>This study demonstrate that heat-induced SIRT1 activation mediates survival of DNA damaged keratinocytes through deacetylation of p53 after exposure to UVB <italic>plus</italic>
heat</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1186/s12895-017-0060-y) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Madan, V" uniqKey="Madan V">V Madan</name>
</author>
<author><name sortKey="Lear, Jt" uniqKey="Lear J">JT Lear</name>
</author>
<author><name sortKey="Szeimies, Rm" uniqKey="Szeimies R">RM Szeimies</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Welsh, Mm" uniqKey="Welsh M">MM Welsh</name>
</author>
<author><name sortKey="Karagas, Mr" uniqKey="Karagas M">MR Karagas</name>
</author>
<author><name sortKey="Kuriger, Jk" uniqKey="Kuriger J">JK Kuriger</name>
</author>
<author><name sortKey="Houseman, A" uniqKey="Houseman A">A Houseman</name>
</author>
<author><name sortKey="Spencer, Sk" uniqKey="Spencer S">SK Spencer</name>
</author>
<author><name sortKey="Perry, Ae" uniqKey="Perry A">AE Perry</name>
</author>
<author><name sortKey="Nelson, Hh" uniqKey="Nelson H">HH Nelson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, L" uniqKey="Liu L">L Liu</name>
</author>
<author><name sortKey="Rezvani, Hr" uniqKey="Rezvani H">HR Rezvani</name>
</author>
<author><name sortKey="Back, Jh" uniqKey="Back J">JH Back</name>
</author>
<author><name sortKey="Hosseini, M" uniqKey="Hosseini M">M Hosseini</name>
</author>
<author><name sortKey="Tang, X" uniqKey="Tang X">X Tang</name>
</author>
<author><name sortKey="Zhu, Y" uniqKey="Zhu Y">Y Zhu</name>
</author>
<author><name sortKey="Mahfouf, W" uniqKey="Mahfouf W">W Mahfouf</name>
</author>
<author><name sortKey="Raad, H" uniqKey="Raad H">H Raad</name>
</author>
<author><name sortKey="Raji, G" uniqKey="Raji G">G Raji</name>
</author>
<author><name sortKey="Athar, M" uniqKey="Athar M">M Athar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Herbert, Kj" uniqKey="Herbert K">KJ Herbert</name>
</author>
<author><name sortKey="Cook, Al" uniqKey="Cook A">AL Cook</name>
</author>
<author><name sortKey="Snow, Et" uniqKey="Snow E">ET Snow</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Der Leun, Jc" uniqKey="Van Der Leun J">JC van der Leun</name>
</author>
<author><name sortKey="Piacentini, Rd" uniqKey="Piacentini R">RD Piacentini</name>
</author>
<author><name sortKey="De Gruijl, Fr" uniqKey="De Gruijl F">FR de Gruijl</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Freedman, Dm" uniqKey="Freedman D">DM Freedman</name>
</author>
<author><name sortKey="Kitahara, C" uniqKey="Kitahara C">C Kitahara</name>
</author>
<author><name sortKey="Linet, M" uniqKey="Linet M">M Linet</name>
</author>
<author><name sortKey="Alexander, B" uniqKey="Alexander B">B Alexander</name>
</author>
<author><name sortKey="Neta, G" uniqKey="Neta G">G Neta</name>
</author>
<author><name sortKey="Little, M" uniqKey="Little M">M Little</name>
</author>
<author><name sortKey="Cahoon, E" uniqKey="Cahoon E">E Cahoon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Calapre, L" uniqKey="Calapre L">L Calapre</name>
</author>
<author><name sortKey="Gray, Es" uniqKey="Gray E">ES Gray</name>
</author>
<author><name sortKey="Ziman, M" uniqKey="Ziman M">M Ziman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maytin, Ev" uniqKey="Maytin E">EV Maytin</name>
</author>
<author><name sortKey="Wimberly, Jm" uniqKey="Wimberly J">JM Wimberly</name>
</author>
<author><name sortKey="Kane, Ks" uniqKey="Kane K">KS Kane</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Trautinger, F" uniqKey="Trautinger F">F Trautinger</name>
</author>
<author><name sortKey="Kindas Mugge, I" uniqKey="Kindas Mugge I">I Kindas-Mugge</name>
</author>
<author><name sortKey="Barlan, B" uniqKey="Barlan B">B Barlan</name>
</author>
<author><name sortKey="Neuner, P" uniqKey="Neuner P">P Neuner</name>
</author>
<author><name sortKey="Knobler, Rm" uniqKey="Knobler R">RM Knobler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kane, Ks" uniqKey="Kane K">KS Kane</name>
</author>
<author><name sortKey="Maytin, Ev" uniqKey="Maytin E">EV Maytin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maytin, Ev" uniqKey="Maytin E">EV Maytin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jantschitsch, C" uniqKey="Jantschitsch C">C Jantschitsch</name>
</author>
<author><name sortKey="Kindas Mugge, I" uniqKey="Kindas Mugge I">I Kindas-Mugge</name>
</author>
<author><name sortKey="Metze, D" uniqKey="Metze D">D Metze</name>
</author>
<author><name sortKey="Amann, G" uniqKey="Amann G">G Amann</name>
</author>
<author><name sortKey="Micksche, M" uniqKey="Micksche M">M Micksche</name>
</author>
<author><name sortKey="Trautinger, F" uniqKey="Trautinger F">F Trautinger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jantschitsch, C" uniqKey="Jantschitsch C">C Jantschitsch</name>
</author>
<author><name sortKey="Trautinger, F" uniqKey="Trautinger F">F Trautinger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Calapre, L" uniqKey="Calapre L">L Calapre</name>
</author>
<author><name sortKey="Gray, Es" uniqKey="Gray E">ES Gray</name>
</author>
<author><name sortKey="Kurdykowski, S" uniqKey="Kurdykowski S">S Kurdykowski</name>
</author>
<author><name sortKey="David, A" uniqKey="David A">A David</name>
</author>
<author><name sortKey="Hart, P" uniqKey="Hart P">P Hart</name>
</author>
<author><name sortKey="Descargues, P" uniqKey="Descargues P">P Descargues</name>
</author>
<author><name sortKey="Ziman, M" uniqKey="Ziman M">M Ziman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jang, Sy" uniqKey="Jang S">SY Jang</name>
</author>
<author><name sortKey="Kim, Sy" uniqKey="Kim S">SY Kim</name>
</author>
<author><name sortKey="Bae, Ys" uniqKey="Bae Y">YS Bae</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, Dh" uniqKey="Kim D">DH Kim</name>
</author>
<author><name sortKey="Jung, Yj" uniqKey="Jung Y">YJ Jung</name>
</author>
<author><name sortKey="Lee, Je" uniqKey="Lee J">JE Lee</name>
</author>
<author><name sortKey="Lee, As" uniqKey="Lee A">AS Lee</name>
</author>
<author><name sortKey="Kang, Kp" uniqKey="Kang K">KP Kang</name>
</author>
<author><name sortKey="Lee, S" uniqKey="Lee S">S Lee</name>
</author>
<author><name sortKey="Park, Sk" uniqKey="Park S">SK Park</name>
</author>
<author><name sortKey="Han, Mk" uniqKey="Han M">MK Han</name>
</author>
<author><name sortKey="Lee, Sy" uniqKey="Lee S">SY Lee</name>
</author>
<author><name sortKey="Ramkumar, Km" uniqKey="Ramkumar K">KM Ramkumar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kume, S" uniqKey="Kume S">S Kume</name>
</author>
<author><name sortKey="Haneda, M" uniqKey="Haneda M">M Haneda</name>
</author>
<author><name sortKey="Kanasaki, K" uniqKey="Kanasaki K">K Kanasaki</name>
</author>
<author><name sortKey="Sugimoto, T" uniqKey="Sugimoto T">T Sugimoto</name>
</author>
<author><name sortKey="Araki, S" uniqKey="Araki S">S Araki</name>
</author>
<author><name sortKey="Isono, M" uniqKey="Isono M">M Isono</name>
</author>
<author><name sortKey="Isshiki, K" uniqKey="Isshiki K">K Isshiki</name>
</author>
<author><name sortKey="Uzu, T" uniqKey="Uzu T">T Uzu</name>
</author>
<author><name sortKey="Kashiwagi, A" uniqKey="Kashiwagi A">A Kashiwagi</name>
</author>
<author><name sortKey="Koya, D" uniqKey="Koya D">D Koya</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Donmez, G" uniqKey="Donmez G">G Donmez</name>
</author>
<author><name sortKey="Arun, A" uniqKey="Arun A">A Arun</name>
</author>
<author><name sortKey="Chung, Cy" uniqKey="Chung C">CY Chung</name>
</author>
<author><name sortKey="Mclean, Pj" uniqKey="Mclean P">PJ McLean</name>
</author>
<author><name sortKey="Lindquist, S" uniqKey="Lindquist S">S Lindquist</name>
</author>
<author><name sortKey="Guarente, L" uniqKey="Guarente L">L Guarente</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Westerheide, Sd" uniqKey="Westerheide S">SD Westerheide</name>
</author>
<author><name sortKey="Anckar, J" uniqKey="Anckar J">J Anckar</name>
</author>
<author><name sortKey="Stevens, Sm" uniqKey="Stevens S">SM Stevens</name>
</author>
<author><name sortKey="Sistonen, L" uniqKey="Sistonen L">L Sistonen</name>
</author>
<author><name sortKey="Morimoto, Ri" uniqKey="Morimoto R">RI Morimoto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chou, Ww" uniqKey="Chou W">WW Chou</name>
</author>
<author><name sortKey="Chen, Kc" uniqKey="Chen K">KC Chen</name>
</author>
<author><name sortKey="Wang, Ys" uniqKey="Wang Y">YS Wang</name>
</author>
<author><name sortKey="Wang, Jy" uniqKey="Wang J">JY Wang</name>
</author>
<author><name sortKey="Liang, Cl" uniqKey="Liang C">CL Liang</name>
</author>
<author><name sortKey="Juo, Sh" uniqKey="Juo S">SH Juo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gonfloni, S" uniqKey="Gonfloni S">S Gonfloni</name>
</author>
<author><name sortKey="Iannizzotto, V" uniqKey="Iannizzotto V">V Iannizzotto</name>
</author>
<author><name sortKey="Maiani, E" uniqKey="Maiani E">E Maiani</name>
</author>
<author><name sortKey="Bellusci, G" uniqKey="Bellusci G">G Bellusci</name>
</author>
<author><name sortKey="Ciccone, S" uniqKey="Ciccone S">S Ciccone</name>
</author>
<author><name sortKey="Diederich, M" uniqKey="Diederich M">M Diederich</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wilking, Mj" uniqKey="Wilking M">MJ Wilking</name>
</author>
<author><name sortKey="Singh, C" uniqKey="Singh C">C Singh</name>
</author>
<author><name sortKey="Nihal, M" uniqKey="Nihal M">M Nihal</name>
</author>
<author><name sortKey="Zhong, W" uniqKey="Zhong W">W Zhong</name>
</author>
<author><name sortKey="Ahmad, N" uniqKey="Ahmad N">N Ahmad</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lou, G" uniqKey="Lou G">G Lou</name>
</author>
<author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name>
</author>
<author><name sortKey="Wu, S" uniqKey="Wu S">S Wu</name>
</author>
<author><name sortKey="Xue, J" uniqKey="Xue J">J Xue</name>
</author>
<author><name sortKey="Yang, F" uniqKey="Yang F">F Yang</name>
</author>
<author><name sortKey="Fu, H" uniqKey="Fu H">H Fu</name>
</author>
<author><name sortKey="Zheng, M" uniqKey="Zheng M">M Zheng</name>
</author>
<author><name sortKey="Chen, Z" uniqKey="Chen Z">Z Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Raynes, R" uniqKey="Raynes R">R Raynes</name>
</author>
<author><name sortKey="Brunquell, J" uniqKey="Brunquell J">J Brunquell</name>
</author>
<author><name sortKey="Westerheide, Sd" uniqKey="Westerheide S">SD Westerheide</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Glozak, Ma" uniqKey="Glozak M">MA Glozak</name>
</author>
<author><name sortKey="Seto, E" uniqKey="Seto E">E Seto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cao, C" uniqKey="Cao C">C Cao</name>
</author>
<author><name sortKey="Lu, S" uniqKey="Lu S">S Lu</name>
</author>
<author><name sortKey="Kivlin, R" uniqKey="Kivlin R">R Kivlin</name>
</author>
<author><name sortKey="Wallin, B" uniqKey="Wallin B">B Wallin</name>
</author>
<author><name sortKey="Card, E" uniqKey="Card E">E Card</name>
</author>
<author><name sortKey="Bagdasarian, A" uniqKey="Bagdasarian A">A Bagdasarian</name>
</author>
<author><name sortKey="Tamakloe, T" uniqKey="Tamakloe T">T Tamakloe</name>
</author>
<author><name sortKey="Wang, Wj" uniqKey="Wang W">WJ Wang</name>
</author>
<author><name sortKey="Song, X" uniqKey="Song X">X Song</name>
</author>
<author><name sortKey="Chu, Wm" uniqKey="Chu W">WM Chu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Leeuwen, Im" uniqKey="Van Leeuwen I">IM van Leeuwen</name>
</author>
<author><name sortKey="Higgins, M" uniqKey="Higgins M">M Higgins</name>
</author>
<author><name sortKey="Campbell, J" uniqKey="Campbell J">J Campbell</name>
</author>
<author><name sortKey="Mccarthy, Ar" uniqKey="Mccarthy A">AR McCarthy</name>
</author>
<author><name sortKey="Sachweh, Mc" uniqKey="Sachweh M">MC Sachweh</name>
</author>
<author><name sortKey="Navarro, Am" uniqKey="Navarro A">AM Navarro</name>
</author>
<author><name sortKey="Lain, S" uniqKey="Lain S">S Lain</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xu, Y" uniqKey="Xu Y">Y Xu</name>
</author>
<author><name sortKey="Li, N" uniqKey="Li N">N Li</name>
</author>
<author><name sortKey="Xiang, R" uniqKey="Xiang R">R Xiang</name>
</author>
<author><name sortKey="Sun, P" uniqKey="Sun P">P Sun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chakraborty, A" uniqKey="Chakraborty A">A Chakraborty</name>
</author>
<author><name sortKey="Uechi, T" uniqKey="Uechi T">T Uechi</name>
</author>
<author><name sortKey="Kenmochi, N" uniqKey="Kenmochi N">N Kenmochi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chipuk, Je" uniqKey="Chipuk J">JE Chipuk</name>
</author>
<author><name sortKey="Green, Dr" uniqKey="Green D">DR Green</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Winter, M" uniqKey="Winter M">M Winter</name>
</author>
<author><name sortKey="Moser, Ma" uniqKey="Moser M">MA Moser</name>
</author>
<author><name sortKey="Meunier, D" uniqKey="Meunier D">D Meunier</name>
</author>
<author><name sortKey="Fischer, C" uniqKey="Fischer C">C Fischer</name>
</author>
<author><name sortKey="Machat, G" uniqKey="Machat G">G Machat</name>
</author>
<author><name sortKey="Mattes, K" uniqKey="Mattes K">K Mattes</name>
</author>
<author><name sortKey="Lichtenberger, Bm" uniqKey="Lichtenberger B">BM Lichtenberger</name>
</author>
<author><name sortKey="Brunmeir, R" uniqKey="Brunmeir R">R Brunmeir</name>
</author>
<author><name sortKey="Weissmann, S" uniqKey="Weissmann S">S Weissmann</name>
</author>
<author><name sortKey="Murko, C" uniqKey="Murko C">C Murko</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Murphy, M" uniqKey="Murphy M">M Murphy</name>
</author>
<author><name sortKey="Mabruk, Mj" uniqKey="Mabruk M">MJ Mabruk</name>
</author>
<author><name sortKey="Lenane, P" uniqKey="Lenane P">P Lenane</name>
</author>
<author><name sortKey="Liew, A" uniqKey="Liew A">A Liew</name>
</author>
<author><name sortKey="Mccann, P" uniqKey="Mccann P">P McCann</name>
</author>
<author><name sortKey="Buckley, A" uniqKey="Buckley A">A Buckley</name>
</author>
<author><name sortKey="O Flatharta, C" uniqKey="O Flatharta C">C O Flatharta</name>
</author>
<author><name sortKey="Hevey, D" uniqKey="Hevey D">D Hevey</name>
</author>
<author><name sortKey="Billet, P" uniqKey="Billet P">P Billet</name>
</author>
<author><name sortKey="Robertson, W" uniqKey="Robertson W">W Robertson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="D Costa, Am" uniqKey="D Costa A">AM D'Costa</name>
</author>
<author><name sortKey="Denning, Mf" uniqKey="Denning M">MF Denning</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Piao, Mj" uniqKey="Piao M">MJ Piao</name>
</author>
<author><name sortKey="Hyun, Yj" uniqKey="Hyun Y">YJ Hyun</name>
</author>
<author><name sortKey="Cho, Sj" uniqKey="Cho S">SJ Cho</name>
</author>
<author><name sortKey="Kang, Hk" uniqKey="Kang H">HK Kang</name>
</author>
<author><name sortKey="Yoo, Es" uniqKey="Yoo E">ES Yoo</name>
</author>
<author><name sortKey="Koh, Ys" uniqKey="Koh Y">YS Koh</name>
</author>
<author><name sortKey="Lee, Nh" uniqKey="Lee N">NH Lee</name>
</author>
<author><name sortKey="Ko, Mh" uniqKey="Ko M">MH Ko</name>
</author>
<author><name sortKey="Hyun, Jw" uniqKey="Hyun J">JW Hyun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, Jt" uniqKey="Lee J">JT Lee</name>
</author>
<author><name sortKey="Gu, W" uniqKey="Gu W">W Gu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, Wy" uniqKey="Chen W">WY Chen</name>
</author>
<author><name sortKey="Wang, Dh" uniqKey="Wang D">DH Wang</name>
</author>
<author><name sortKey="Yen, Rc" uniqKey="Yen R">RC Yen</name>
</author>
<author><name sortKey="Luo, J" uniqKey="Luo J">J Luo</name>
</author>
<author><name sortKey="Gu, W" uniqKey="Gu W">W Gu</name>
</author>
<author><name sortKey="Baylin, Sb" uniqKey="Baylin S">SB Baylin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rezvani, Hr" uniqKey="Rezvani H">HR Rezvani</name>
</author>
<author><name sortKey="Rossignol, R" uniqKey="Rossignol R">R Rossignol</name>
</author>
<author><name sortKey="Ali, N" uniqKey="Ali N">N Ali</name>
</author>
<author><name sortKey="Benard, G" uniqKey="Benard G">G Benard</name>
</author>
<author><name sortKey="Tang, X" uniqKey="Tang X">X Tang</name>
</author>
<author><name sortKey="Yang, Hs" uniqKey="Yang H">HS Yang</name>
</author>
<author><name sortKey="Jouary, T" uniqKey="Jouary T">T Jouary</name>
</author>
<author><name sortKey="De Verneuil, H" uniqKey="De Verneuil H">H de Verneuil</name>
</author>
<author><name sortKey="Taieb, A" uniqKey="Taieb A">A Taieb</name>
</author>
<author><name sortKey="Kim, Al" uniqKey="Kim A">AL Kim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bria, E" uniqKey="Bria E">E Bria</name>
</author>
<author><name sortKey="Furlanetto, J" uniqKey="Furlanetto J">J Furlanetto</name>
</author>
<author><name sortKey="Carbognin, L" uniqKey="Carbognin L">L Carbognin</name>
</author>
<author><name sortKey="Brunelli, M" uniqKey="Brunelli M">M Brunelli</name>
</author>
<author><name sortKey="Caliolo, C" uniqKey="Caliolo C">C Caliolo</name>
</author>
<author><name sortKey="Nortilli, R" uniqKey="Nortilli R">R Nortilli</name>
</author>
<author><name sortKey="Massari, F" uniqKey="Massari F">F Massari</name>
</author>
<author><name sortKey="Pedron, S" uniqKey="Pedron S">S Pedron</name>
</author>
<author><name sortKey="Manfrin, E" uniqKey="Manfrin E">E Manfrin</name>
</author>
<author><name sortKey="Pellini, F" uniqKey="Pellini F">F Pellini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Katzenberger, T" uniqKey="Katzenberger T">T Katzenberger</name>
</author>
<author><name sortKey="Petzoldt, C" uniqKey="Petzoldt C">C Petzoldt</name>
</author>
<author><name sortKey="Holler, S" uniqKey="Holler S">S Holler</name>
</author>
<author><name sortKey="Mader, U" uniqKey="Mader U">U Mader</name>
</author>
<author><name sortKey="Kalla, J" uniqKey="Kalla J">J Kalla</name>
</author>
<author><name sortKey="Adam, P" uniqKey="Adam P">P Adam</name>
</author>
<author><name sortKey="Ott, Mm" uniqKey="Ott M">MM Ott</name>
</author>
<author><name sortKey="Muller Hermelink, Hk" uniqKey="Muller Hermelink H">HK Muller-Hermelink</name>
</author>
<author><name sortKey="Rosenwald, A" uniqKey="Rosenwald A">A Rosenwald</name>
</author>
<author><name sortKey="Ott, G" uniqKey="Ott G">G Ott</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kanitakis, J" uniqKey="Kanitakis J">J Kanitakis</name>
</author>
<author><name sortKey="Narvaez, D" uniqKey="Narvaez D">D Narvaez</name>
</author>
<author><name sortKey="Euvrard, S" uniqKey="Euvrard S">S Euvrard</name>
</author>
<author><name sortKey="Faure, M" uniqKey="Faure M">M Faure</name>
</author>
<author><name sortKey="Claudy, A" uniqKey="Claudy A">A Claudy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Putri, Ri" uniqKey="Putri R">RI Putri</name>
</author>
<author><name sortKey="Siregar, Nc" uniqKey="Siregar N">NC Siregar</name>
</author>
<author><name sortKey="Siregar, B" uniqKey="Siregar B">B Siregar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gertz, M" uniqKey="Gertz M">M Gertz</name>
</author>
<author><name sortKey="Fischer, F" uniqKey="Fischer F">F Fischer</name>
</author>
<author><name sortKey="Nguyen, Gt" uniqKey="Nguyen G">GT Nguyen</name>
</author>
<author><name sortKey="Lakshminarasimhan, M" uniqKey="Lakshminarasimhan M">M Lakshminarasimhan</name>
</author>
<author><name sortKey="Schutkowski, M" uniqKey="Schutkowski M">M Schutkowski</name>
</author>
<author><name sortKey="Weyand, M" uniqKey="Weyand M">M Weyand</name>
</author>
<author><name sortKey="Steegborn, C" uniqKey="Steegborn C">C Steegborn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Peck, B" uniqKey="Peck B">B Peck</name>
</author>
<author><name sortKey="Chen, Cy" uniqKey="Chen C">CY Chen</name>
</author>
<author><name sortKey="Ho, Kk" uniqKey="Ho K">KK Ho</name>
</author>
<author><name sortKey="Di Fruscia, P" uniqKey="Di Fruscia P">P Di Fruscia</name>
</author>
<author><name sortKey="Myatt, Ss" uniqKey="Myatt S">SS Myatt</name>
</author>
<author><name sortKey="Coombes, Rc" uniqKey="Coombes R">RC Coombes</name>
</author>
<author><name sortKey="Fuchter, Mj" uniqKey="Fuchter M">MJ Fuchter</name>
</author>
<author><name sortKey="Hsiao, Cd" uniqKey="Hsiao C">CD Hsiao</name>
</author>
<author><name sortKey="Lam, Ew" uniqKey="Lam E">EW Lam</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ido, Y" uniqKey="Ido Y">Y Ido</name>
</author>
<author><name sortKey="Duranton, A" uniqKey="Duranton A">A Duranton</name>
</author>
<author><name sortKey="Lan, F" uniqKey="Lan F">F Lan</name>
</author>
<author><name sortKey="Weikel, Ka" uniqKey="Weikel K">KA Weikel</name>
</author>
<author><name sortKey="Breton, L" uniqKey="Breton L">L Breton</name>
</author>
<author><name sortKey="Ruderman, Nb" uniqKey="Ruderman N">NB Ruderman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Solomon, Jm" uniqKey="Solomon J">JM Solomon</name>
</author>
<author><name sortKey="Pasupuleti, R" uniqKey="Pasupuleti R">R Pasupuleti</name>
</author>
<author><name sortKey="Xu, L" uniqKey="Xu L">L Xu</name>
</author>
<author><name sortKey="Mcdonagh, T" uniqKey="Mcdonagh T">T McDonagh</name>
</author>
<author><name sortKey="Curtis, R" uniqKey="Curtis R">R Curtis</name>
</author>
<author><name sortKey="Distefano, Ps" uniqKey="Distefano P">PS DiStefano</name>
</author>
<author><name sortKey="Huber, Lj" uniqKey="Huber L">LJ Huber</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cheng, Hl" uniqKey="Cheng H">HL Cheng</name>
</author>
<author><name sortKey="Mostoslavsky, R" uniqKey="Mostoslavsky R">R Mostoslavsky</name>
</author>
<author><name sortKey="Saito, S" uniqKey="Saito S">S Saito</name>
</author>
<author><name sortKey="Manis, Jp" uniqKey="Manis J">JP Manis</name>
</author>
<author><name sortKey="Gu, Y" uniqKey="Gu Y">Y Gu</name>
</author>
<author><name sortKey="Patel, P" uniqKey="Patel P">P Patel</name>
</author>
<author><name sortKey="Bronson, R" uniqKey="Bronson R">R Bronson</name>
</author>
<author><name sortKey="Appella, E" uniqKey="Appella E">E Appella</name>
</author>
<author><name sortKey="Alt, Fw" uniqKey="Alt F">FW Alt</name>
</author>
<author><name sortKey="Chua, Kf" uniqKey="Chua K">KF Chua</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Botta, G" uniqKey="Botta G">G Botta</name>
</author>
<author><name sortKey="De Santis, Lp" uniqKey="De Santis L">LP De Santis</name>
</author>
<author><name sortKey="Saladino, R" uniqKey="Saladino R">R Saladino</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, Dj" uniqKey="Liu D">DJ Liu</name>
</author>
<author><name sortKey="Hammer, D" uniqKey="Hammer D">D Hammer</name>
</author>
<author><name sortKey="Komlos, D" uniqKey="Komlos D">D Komlos</name>
</author>
<author><name sortKey="Chen, Ky" uniqKey="Chen K">KY Chen</name>
</author>
<author><name sortKey="Firestein, Bl" uniqKey="Firestein B">BL Firestein</name>
</author>
<author><name sortKey="Liu, Ay" uniqKey="Liu A">AY Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yi, J" uniqKey="Yi J">J Yi</name>
</author>
<author><name sortKey="Luo, J" uniqKey="Luo J">J Luo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Amundson, Sa" uniqKey="Amundson S">SA Amundson</name>
</author>
<author><name sortKey="Patterson, A" uniqKey="Patterson A">A Patterson</name>
</author>
<author><name sortKey="Do, Kt" uniqKey="Do K">KT Do</name>
</author>
<author><name sortKey="Fornace, Aj" uniqKey="Fornace A">AJ Fornace</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ford, Jm" uniqKey="Ford J">JM Ford</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fitch, Me" uniqKey="Fitch M">ME Fitch</name>
</author>
<author><name sortKey="Cross, Iv" uniqKey="Cross I">IV Cross</name>
</author>
<author><name sortKey="Ford, Jm" uniqKey="Ford J">JM Ford</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Min, Jh" uniqKey="Min J">JH Min</name>
</author>
<author><name sortKey="Pavletich, Np" uniqKey="Pavletich N">NP Pavletich</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sugasawa, K" uniqKey="Sugasawa K">K Sugasawa</name>
</author>
<author><name sortKey="Okamoto, T" uniqKey="Okamoto T">T Okamoto</name>
</author>
<author><name sortKey="Shimizu, Y" uniqKey="Shimizu Y">Y Shimizu</name>
</author>
<author><name sortKey="Masutani, C" uniqKey="Masutani C">C Masutani</name>
</author>
<author><name sortKey="Iwai, S" uniqKey="Iwai S">S Iwai</name>
</author>
<author><name sortKey="Hanaoka, F" uniqKey="Hanaoka F">F Hanaoka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Adimoolam, S" uniqKey="Adimoolam S">S Adimoolam</name>
</author>
<author><name sortKey="Ford, Jm" uniqKey="Ford J">JM Ford</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tan, T" uniqKey="Tan T">T Tan</name>
</author>
<author><name sortKey="Chu, G" uniqKey="Chu G">G Chu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Barckhausen, C" uniqKey="Barckhausen C">C Barckhausen</name>
</author>
<author><name sortKey="Roos, Wp" uniqKey="Roos W">WP Roos</name>
</author>
<author><name sortKey="Naumann, Sc" uniqKey="Naumann S">SC Naumann</name>
</author>
<author><name sortKey="Kaina, B" uniqKey="Kaina B">B Kaina</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Martincorena, I" uniqKey="Martincorena I">I Martincorena</name>
</author>
<author><name sortKey="Roshan, A" uniqKey="Roshan A">A Roshan</name>
</author>
<author><name sortKey="Gerstung, M" uniqKey="Gerstung M">M Gerstung</name>
</author>
<author><name sortKey="Ellis, P" uniqKey="Ellis P">P Ellis</name>
</author>
<author><name sortKey="Van Loo, P" uniqKey="Van Loo P">P Van Loo</name>
</author>
<author><name sortKey="Mclaren, S" uniqKey="Mclaren S">S McLaren</name>
</author>
<author><name sortKey="Wedge, Dc" uniqKey="Wedge D">DC Wedge</name>
</author>
<author><name sortKey="Fullam, A" uniqKey="Fullam A">A Fullam</name>
</author>
<author><name sortKey="Alexandrov, Lb" uniqKey="Alexandrov L">LB Alexandrov</name>
</author>
<author><name sortKey="Tubio, Jm" uniqKey="Tubio J">JM Tubio</name>
</author>
</analytic>
</biblStruct>
</listBibl>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Dermatol</journal-id>
<journal-id journal-id-type="iso-abbrev">BMC Dermatol</journal-id>
<journal-title-group><journal-title>BMC Dermatology</journal-title>
</journal-title-group>
<issn pub-type="epub">1471-5945</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
<publisher-loc>London</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">28601088</article-id>
<article-id pub-id-type="pmc">5466784</article-id>
<article-id pub-id-type="publisher-id">60</article-id>
<article-id pub-id-type="doi">10.1186/s12895-017-0060-y</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>SIRT1 activation mediates heat-induced survival of UVB damaged Keratinocytes</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0001-7595-6523</contrib-id>
<name><surname>Calapre</surname>
<given-names>Leslie</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gray</surname>
<given-names>Elin S.</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kurdykowski</surname>
<given-names>Sandrine</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>David</surname>
<given-names>Anthony</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Descargues</surname>
<given-names>Pascal</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Ziman</surname>
<given-names>Mel</given-names>
</name>
<address><phone>+61 8 6304 5716</phone>
<email>m.ziman@ecu.edu.au</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<aff id="Aff1"><label>1</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0389 4302</institution-id>
<institution-id institution-id-type="GRID">grid.1038.a</institution-id>
<institution>School of Medical Science,</institution>
<institution>Edith Cowan University,</institution>
</institution-wrap>
270 Joondalup Drive, Joondalup, Perth, WA 6027 Australia</aff>
<aff id="Aff2"><label>2</label>
GENOSKIN Centre Pierre Potier, Oncopole, Toulouse, France</aff>
<aff id="Aff3"><label>3</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7910</institution-id>
<institution-id institution-id-type="GRID">grid.1012.2</institution-id>
<institution>School of Pathology and Laboratory Medicine,</institution>
<institution>University of Western Australia,</institution>
</institution-wrap>
Crawley, WA Australia</aff>
</contrib-group>
<pub-date pub-type="epub"><day>10</day>
<month>6</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>10</day>
<month>6</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="collection"><year>2017</year>
</pub-date>
<volume>17</volume>
<elocation-id>8</elocation-id>
<history><date date-type="received"><day>2</day>
<month>12</month>
<year>2016</year>
</date>
<date date-type="accepted"><day>2</day>
<month>6</month>
<year>2017</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s). 2017</copyright-statement>
<license license-type="OpenAccess"><license-p><bold>Open Access</bold>
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>
) applies to the data made available in this article, unless otherwise stated.</license-p>
</license>
</permissions>
<abstract id="Abs1"><sec><title>Background</title>
<p>Exposure to heat stress after UVB irradiation induces a reduction of apoptosis, resulting in survival of DNA damaged human keratinocytes. This heat-mediated evasion of apoptosis appears to be mediated by activation of SIRT1 and inactivation of p53 signalling. In this study, we assessed the role of SIRT1 in the inactivation of p53 signalling and impairment of DNA damage response in UVB <italic>plus</italic>
heat exposed keratinocytes.</p>
</sec>
<sec><title>Results</title>
<p>Activation of SIRT1 after multiple UVB <italic>plus</italic>
heat exposures resulted in increased p53 deacetylation at K382, which is known to affect its binding to specific target genes. Accordingly, we noted decreased apoptosis and down regulation of the p53 targeted pro-apoptotic gene <italic>BAX</italic>
and the DNA repair genes <italic>ERCC1</italic>
and <italic>XPC</italic>
after UVB <italic>plus</italic>
heat treatments. In addition, UVB <italic>plus</italic>
heat induced increased expression of the cell survival gene <italic>Survivin</italic>
and the proliferation marker Ki67. Notably, keratinocytes exposed to UVB <italic>plus</italic>
heat in the presence of the SIRT1 inhibitor, Ex-527, showed a similar phenotype to those exposed to UV alone; i.e. an increase in p53 acetylation, increased apoptosis and low levels of <italic>Survivin</italic>
.</p>
</sec>
<sec><title>Conclusion</title>
<p>This study demonstrate that heat-induced SIRT1 activation mediates survival of DNA damaged keratinocytes through deacetylation of p53 after exposure to UVB <italic>plus</italic>
heat</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1186/s12895-017-0060-y) contains supplementary material, which is available to authorized users.</p>
</sec>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>Heat stress</kwd>
<kwd>UVB</kwd>
<kwd>Keratinocytes</kwd>
<kwd>Apoptosis</kwd>
<kwd>p53</kwd>
<kwd>SIRT1</kwd>
<kwd>p53 deacetylation</kwd>
</kwd-group>
<funding-group><award-group><funding-source><institution-wrap><institution-id institution-id-type="FundRef">http://dx.doi.org/10.13039/501100001798</institution-id>
<institution>Edith Cowan University</institution>
</institution-wrap>
</funding-source>
</award-group>
</funding-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2017</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>France</li>
</country>
<region><li>Midi-Pyrénées</li>
<li>Occitanie (région administrative)</li>
</region>
<settlement><li>Toulouse</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Calapre, Leslie" sort="Calapre, Leslie" uniqKey="Calapre L" first="Leslie" last="Calapre">Leslie Calapre</name>
<name sortKey="Gray, Elin S" sort="Gray, Elin S" uniqKey="Gray E" first="Elin S." last="Gray">Elin S. Gray</name>
<name sortKey="Ziman, Mel" sort="Ziman, Mel" uniqKey="Ziman M" first="Mel" last="Ziman">Mel Ziman</name>
</noCountry>
<country name="France"><region name="Occitanie (région administrative)"><name sortKey="Kurdykowski, Sandrine" sort="Kurdykowski, Sandrine" uniqKey="Kurdykowski S" first="Sandrine" last="Kurdykowski">Sandrine Kurdykowski</name>
</region>
<name sortKey="David, Anthony" sort="David, Anthony" uniqKey="David A" first="Anthony" last="David">Anthony David</name>
<name sortKey="Descargues, Pascal" sort="Descargues, Pascal" uniqKey="Descargues P" first="Pascal" last="Descargues">Pascal Descargues</name>
</country>
</tree>
</affiliations>
</record>
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