AustralieFrV1, PascalFrancis, Curation, bibRecord, 006700

Identification of the multiple endocrine neoplasia type 1 (MEN1) gene

Identifieur interne : 006700 ( PascalFrancis/Curation ); précédent : 006699; suivant : 006701

Identification of the multiple endocrine neoplasia type 1 (MEN1) gene

Auteurs : I. Lemmens [Belgique] ; W. J. M. Van De Ven [Belgique] ; K. Kas [Belgique] ; C. X. Zhang [France] ; S. Giraud [France] ; V. Wautot [France] ; N. Buisson [France] ; K. De Witte [France] ; J. Salandre [France] ; G. Lenoir [France] ; M. Pugeat [France] ; A. Calender [France] ; F. Parente [France] ; D. Quincey [France] ; P. Gaudray [France] ; M. J. De Wit [Pays-Bas] ; C. J. M. Lips [Pays-Bas] ; J. W. M. Höppener [Pays-Bas] ; S. Khodaei [Suède] ; A. L. Grant [Suède] ; G. Weber [Suède] ; S. Kytöl [Suède, Finlande] ; B. T. Teh [Suède] ; F. Farnebo [Suède] ; C. Phelan [Suède] ; N. Hayward [Australie] ; C. Larsson [Suède] ; A. A. J. Pannett [Royaume-Uni] ; S. A. Forbes [Royaume-Uni] ; J. H. D. Bassett [Royaume-Uni] ; R. V. Thakker [Royaume-Uni]

Source :

Human molecular genetics [ 0964-6906 ] ; 1997.

RBID : Pascal:97-0389518

Descripteurs français

Pascal (Inist)
- Homme, Génétique, Chromosome C11, Carte génétique, Mutation, Gène suppresseur tumeur, Expression génique, Hyperparathyroïdie, Polyadénomatose endocrinienne I.
Wicri :
- topic : Homme, Génétique.

English descriptors

KwdEn :
- Chromosome C11, Gene expression, Genetic mapping, Genetics, Human, Hyperparathyroidism, Multiple endocrine neoplasia type I, Mutation, Tumor suppressor gene.

Abstract

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterised by tumours of the parathyroids, pancreas and anterior pituitary that represents one of the familial cancer syndromes. The MEN1 locus has been previously localised to chromosome 11q13, and a <300 kb gene-rich region flanked centromerically by PYGM and telomerically by D11S1783 defined by combined meiotic and tumour deletion mapping studies. Two candidate genes, ZFM1 and PPP2RSB, from this region have been previously excluded, and in order to identify additional candidate genes we used a BAC to isolate cDNAs from a bovine parathyroid cDNA library by direct selection. One of the novel genes that we identified, SCG2, proved to be identical to the recently published MEN1 gene, which is likely to be a tumour suppressor gene. The SCG2 transcript was 2.9 kb in all tissues with an additional 4.2 kb transcript also being present in the pancreas and thymus. Mutational analysis of SCG2 in 10 unrelated MEN1 families identified one polymorphism and nine different heterozygous mutations (one missense, four non-sense, one insertional and three deletional frameshifts) that segregated with the disease, hence providing an independent confirmation for the identification of the MEN1 gene.

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A14	`05`			`@1 Instabilité et altérations des Génomes, UNSA/CNRS UMR 6549, Avenue de Valombrose @2 06107 Nice @3 FRA @Z 13 aut. @Z 14 aut. @Z 15 aut.`
A14	`06`			`@1 Utrecht University Hospital, Departments of Internal Medicine and Pathology, H04-313, PO Box 85500, Heidelberglaan 100 @2 3508 GA Utrecht @3 NLD @Z 16 aut. @Z 17 aut. @Z 18 aut.`
A14	`07`			`@1 Department of Molecular Medicine, Karolinska Hospital, Clinical Genetics Unit, CMM L8:02 @2 171 76 Stockholm @3 SWE @Z 19 aut. @Z 20 aut. @Z 21 aut.`
A14	`08`			`@1 Department of Molecular Medicine, Endocrine tumour unit, Karolinska Hospital, CMM L8:01 @2 171 76 Stockholm @3 SWE @Z 22 aut. @Z 23 aut. @Z 24 aut. @Z 25 aut. @Z 27 aut.`
A14	`09`			`@1 Department of Clinical Genetics, Oulu University Hospital @2 Oulu @3 FIN @Z 22 aut.`
A14	`10`			`@1 Queensland Institute of Medical Research, Human Genetics Laboratory @2 Herston 4029, Queensland @3 AUS @Z 26 aut.`
A14	`11`			`@1 MRC Molecular Endocrinology Group, MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road @2 London W12 0NN @3 GBR @Z 28 aut. @Z 29 aut. @Z 30 aut. @Z 31 aut.`
A17	`01`	`1`		`@1 The European Consortium on MEN1 @3 INC`
A20				`@1 1177-1183`
A21				`@1 1997`
A23	`01`			`@0 ENG`
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C01	`01`		`ENG`	@0 Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterised by tumours of the parathyroids, pancreas and anterior pituitary that represents one of the familial cancer syndromes. The MEN1 locus has been previously localised to chromosome 11q13, and a <300 kb gene-rich region flanked centromerically by PYGM and telomerically by D11S1783 defined by combined meiotic and tumour deletion mapping studies. Two candidate genes, ZFM1 and PPP2RSB, from this region have been previously excluded, and in order to identify additional candidate genes we used a BAC to isolate cDNAs from a bovine parathyroid cDNA library by direct selection. One of the novel genes that we identified, SCG2, proved to be identical to the recently published MEN1 gene, which is likely to be a tumour suppressor gene. The SCG2 transcript was 2.9 kb in all tissues with an additional 4.2 kb transcript also being present in the pancreas and thymus. Mutational analysis of SCG2 in 10 unrelated MEN1 families identified one polymorphism and nine different heterozygous mutations (one missense, four non-sense, one insertional and three deletional frameshifts) that segregated with the disease, hence providing an independent confirmation for the identification of the MEN1 gene.
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Le document en format XML

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<author><name sortKey="Quincey, D" sort="Quincey, D" uniqKey="Quincey D" first="D." last="Quincey">D. Quincey</name>
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<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
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</author>
<author><name sortKey="Gaudray, P" sort="Gaudray, P" uniqKey="Gaudray P" first="P." last="Gaudray">P. Gaudray</name>
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<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
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<country>France</country>
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</author>
<author><name sortKey="De Wit, M J" sort="De Wit, M J" uniqKey="De Wit M" first="M. J." last="De Wit">M. J. De Wit</name>
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<sZ>16 aut.</sZ>
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<author><name sortKey="Lips, C J M" sort="Lips, C J M" uniqKey="Lips C" first="C. J. M." last="Lips">C. J. M. Lips</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Utrecht University Hospital, Departments of Internal Medicine and Pathology, H04-313, PO Box 85500, Heidelberglaan 100</s1>
<s2>3508 GA Utrecht</s2>
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<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
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<author><name sortKey="Hoppener, J W M" sort="Hoppener, J W M" uniqKey="Hoppener J" first="J. W. M." last="Höppener">J. W. M. Höppener</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Utrecht University Hospital, Departments of Internal Medicine and Pathology, H04-313, PO Box 85500, Heidelberglaan 100</s1>
<s2>3508 GA Utrecht</s2>
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<sZ>16 aut.</sZ>
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<country>Pays-Bas</country>
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<author><name sortKey="Khodaei, S" sort="Khodaei, S" uniqKey="Khodaei S" first="S." last="Khodaei">S. Khodaei</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Molecular Medicine, Karolinska Hospital, Clinical Genetics Unit, CMM L8:02</s1>
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<author><name sortKey="Grant, A L" sort="Grant, A L" uniqKey="Grant A" first="A. L." last="Grant">A. L. Grant</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Molecular Medicine, Karolinska Hospital, Clinical Genetics Unit, CMM L8:02</s1>
<s2>171 76 Stockholm</s2>
<s3>SWE</s3>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
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<country>Suède</country>
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</author>
<author><name sortKey="Weber, G" sort="Weber, G" uniqKey="Weber G" first="G." last="Weber">G. Weber</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Molecular Medicine, Karolinska Hospital, Clinical Genetics Unit, CMM L8:02</s1>
<s2>171 76 Stockholm</s2>
<s3>SWE</s3>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
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<country>Suède</country>
</affiliation>
</author>
<author><name sortKey="Kytol, S" sort="Kytol, S" uniqKey="Kytol S" first="S." last="Kytöl">S. Kytöl</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Molecular Medicine, Endocrine tumour unit, Karolinska Hospital, CMM L8:01</s1>
<s2>171 76 Stockholm</s2>
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<sZ>24 aut.</sZ>
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<country>Suède</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Clinical Genetics, Oulu University Hospital</s1>
<s2>Oulu</s2>
<s3>FIN</s3>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
</affiliation>
</author>
<author><name sortKey="Teh, B T" sort="Teh, B T" uniqKey="Teh B" first="B. T." last="Teh">B. T. Teh</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Molecular Medicine, Endocrine tumour unit, Karolinska Hospital, CMM L8:01</s1>
<s2>171 76 Stockholm</s2>
<s3>SWE</s3>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
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<country>Suède</country>
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<author><name sortKey="Farnebo, F" sort="Farnebo, F" uniqKey="Farnebo F" first="F." last="Farnebo">F. Farnebo</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Molecular Medicine, Endocrine tumour unit, Karolinska Hospital, CMM L8:01</s1>
<s2>171 76 Stockholm</s2>
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<sZ>23 aut.</sZ>
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<country>Suède</country>
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<author><name sortKey="Phelan, C" sort="Phelan, C" uniqKey="Phelan C" first="C." last="Phelan">C. Phelan</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Molecular Medicine, Endocrine tumour unit, Karolinska Hospital, CMM L8:01</s1>
<s2>171 76 Stockholm</s2>
<s3>SWE</s3>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>27 aut.</sZ>
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<country>Suède</country>
</affiliation>
</author>
<author><name sortKey="Hayward, N" sort="Hayward, N" uniqKey="Hayward N" first="N." last="Hayward">N. Hayward</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Queensland Institute of Medical Research, Human Genetics Laboratory</s1>
<s2> Herston 4029, Queensland</s2>
<s3>AUS</s3>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Australie</country>
</affiliation>
</author>
<author><name sortKey="Larsson, C" sort="Larsson, C" uniqKey="Larsson C" first="C." last="Larsson">C. Larsson</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Molecular Medicine, Endocrine tumour unit, Karolinska Hospital, CMM L8:01</s1>
<s2>171 76 Stockholm</s2>
<s3>SWE</s3>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>Suède</country>
</affiliation>
</author>
<author><name sortKey="Pannett, A A J" sort="Pannett, A A J" uniqKey="Pannett A" first="A. A. J." last="Pannett">A. A. J. Pannett</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>MRC Molecular Endocrinology Group, MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road</s1>
<s2>London W12 0NN</s2>
<s3>GBR</s3>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author><name sortKey="Forbes, S A" sort="Forbes, S A" uniqKey="Forbes S" first="S. A." last="Forbes">S. A. Forbes</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>MRC Molecular Endocrinology Group, MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road</s1>
<s2>London W12 0NN</s2>
<s3>GBR</s3>
<sZ>28 aut.</sZ>
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<sZ>30 aut.</sZ>
<sZ>31 aut.</sZ>
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<country>Royaume-Uni</country>
</affiliation>
</author>
<author><name sortKey="Bassett, J H D" sort="Bassett, J H D" uniqKey="Bassett J" first="J. H. D." last="Bassett">J. H. D. Bassett</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>MRC Molecular Endocrinology Group, MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road</s1>
<s2>London W12 0NN</s2>
<s3>GBR</s3>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author><name sortKey="Thakker, R V" sort="Thakker, R V" uniqKey="Thakker R" first="R. V." last="Thakker">R. V. Thakker</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>MRC Molecular Endocrinology Group, MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road</s1>
<s2>London W12 0NN</s2>
<s3>GBR</s3>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">97-0389518</idno>
<date when="1997">1997</date>
<idno type="stanalyst">PASCAL 97-0389518 INIST</idno>
<idno type="RBID">Pascal:97-0389518</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">006969</idno>
<idno type="wicri:Area/PascalFrancis/Curation">006700</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Identification of the multiple endocrine neoplasia type 1 (MEN1) gene</title>
<author><name sortKey="Lemmens, I" sort="Lemmens, I" uniqKey="Lemmens I" first="I." last="Lemmens">I. Lemmens</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory for Molecular Oncology and Flanders Interuniversity Institute for Biotechnology, Center for Human Genetics, KU Leuven, Herestraat 49</s1>
<s2>3000 Leuven</s2>
<s3>BEL</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Belgique</country>
</affiliation>
</author>
<author><name sortKey="Van De Ven, W J M" sort="Van De Ven, W J M" uniqKey="Van De Ven W" first="W. J. M." last="Van De Ven">W. J. M. Van De Ven</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory for Molecular Oncology and Flanders Interuniversity Institute for Biotechnology, Center for Human Genetics, KU Leuven, Herestraat 49</s1>
<s2>3000 Leuven</s2>
<s3>BEL</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Belgique</country>
</affiliation>
</author>
<author><name sortKey="Kas, K" sort="Kas, K" uniqKey="Kas K" first="K." last="Kas">K. Kas</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory for Molecular Oncology and Flanders Interuniversity Institute for Biotechnology, Center for Human Genetics, KU Leuven, Herestraat 49</s1>
<s2>3000 Leuven</s2>
<s3>BEL</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Belgique</country>
</affiliation>
</author>
<author><name sortKey="Zhang, C X" sort="Zhang, C X" uniqKey="Zhang C" first="C. X." last="Zhang">C. X. Zhang</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>GENEM 1 (Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1): Genetic Unit, Hôpital Edouard Herriot,</s1>
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<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
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<country>France</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>GENEM 1 (Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1):Laboratory of genetics and cancer, CNRS UMR5641, Medical University Claude Bernard Lyon 1</s1>
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<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
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</affiliation>
</author>
<author><name sortKey="Giraud, S" sort="Giraud, S" uniqKey="Giraud S" first="S." last="Giraud">S. Giraud</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>GENEM 1 (Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1): Genetic Unit, Hôpital Edouard Herriot,</s1>
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<country>France</country>
</affiliation>
</author>
<author><name sortKey="Wautot, V" sort="Wautot, V" uniqKey="Wautot V" first="V." last="Wautot">V. Wautot</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>GENEM 1 (Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1):Laboratory of genetics and cancer, CNRS UMR5641, Medical University Claude Bernard Lyon 1</s1>
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<country>France</country>
</affiliation>
</author>
<author><name sortKey="Buisson, N" sort="Buisson, N" uniqKey="Buisson N" first="N." last="Buisson">N. Buisson</name>
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<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>GENEM 1 (Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1):Laboratory of genetics and cancer, CNRS UMR5641, Medical University Claude Bernard Lyon 1</s1>
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<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
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<country>France</country>
</affiliation>
</author>
<author><name sortKey="De Witte, K" sort="De Witte, K" uniqKey="De Witte K" first="K." last="De Witte">K. De Witte</name>
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<sZ>12 aut.</sZ>
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<country>France</country>
</affiliation>
</author>
<author><name sortKey="Salandre, J" sort="Salandre, J" uniqKey="Salandre J" first="J." last="Salandre">J. Salandre</name>
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<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
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<country>France</country>
</affiliation>
</author>
<author><name sortKey="Lenoir, G" sort="Lenoir, G" uniqKey="Lenoir G" first="G." last="Lenoir">G. Lenoir</name>
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<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
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<country>France</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>GENEM 1 (Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1):Laboratory of genetics and cancer, CNRS UMR5641, Medical University Claude Bernard Lyon 1</s1>
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<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
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<country>France</country>
</affiliation>
</author>
<author><name sortKey="Pugeat, M" sort="Pugeat, M" uniqKey="Pugeat M" first="M." last="Pugeat">M. Pugeat</name>
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<s3>FRA</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Calender, A" sort="Calender, A" uniqKey="Calender A" first="A." last="Calender">A. Calender</name>
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<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>GENEM 1 (Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1):Laboratory of genetics and cancer, CNRS UMR5641, Medical University Claude Bernard Lyon 1</s1>
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<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
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</affiliation>
</author>
<author><name sortKey="Parente, F" sort="Parente, F" uniqKey="Parente F" first="F." last="Parente">F. Parente</name>
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<sZ>14 aut.</sZ>
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</affiliation>
</author>
<author><name sortKey="Quincey, D" sort="Quincey, D" uniqKey="Quincey D" first="D." last="Quincey">D. Quincey</name>
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<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
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<country>France</country>
</affiliation>
</author>
<author><name sortKey="Gaudray, P" sort="Gaudray, P" uniqKey="Gaudray P" first="P." last="Gaudray">P. Gaudray</name>
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<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
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<country>France</country>
</affiliation>
</author>
<author><name sortKey="De Wit, M J" sort="De Wit, M J" uniqKey="De Wit M" first="M. J." last="De Wit">M. J. De Wit</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Utrecht University Hospital, Departments of Internal Medicine and Pathology, H04-313, PO Box 85500, Heidelberglaan 100</s1>
<s2>3508 GA Utrecht</s2>
<s3>NLD</s3>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
</affiliation>
</author>
<author><name sortKey="Lips, C J M" sort="Lips, C J M" uniqKey="Lips C" first="C. J. M." last="Lips">C. J. M. Lips</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Utrecht University Hospital, Departments of Internal Medicine and Pathology, H04-313, PO Box 85500, Heidelberglaan 100</s1>
<s2>3508 GA Utrecht</s2>
<s3>NLD</s3>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
</affiliation>
</author>
<author><name sortKey="Hoppener, J W M" sort="Hoppener, J W M" uniqKey="Hoppener J" first="J. W. M." last="Höppener">J. W. M. Höppener</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Utrecht University Hospital, Departments of Internal Medicine and Pathology, H04-313, PO Box 85500, Heidelberglaan 100</s1>
<s2>3508 GA Utrecht</s2>
<s3>NLD</s3>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
</affiliation>
</author>
<author><name sortKey="Khodaei, S" sort="Khodaei, S" uniqKey="Khodaei S" first="S." last="Khodaei">S. Khodaei</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Molecular Medicine, Karolinska Hospital, Clinical Genetics Unit, CMM L8:02</s1>
<s2>171 76 Stockholm</s2>
<s3>SWE</s3>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Suède</country>
</affiliation>
</author>
<author><name sortKey="Grant, A L" sort="Grant, A L" uniqKey="Grant A" first="A. L." last="Grant">A. L. Grant</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Molecular Medicine, Karolinska Hospital, Clinical Genetics Unit, CMM L8:02</s1>
<s2>171 76 Stockholm</s2>
<s3>SWE</s3>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Suède</country>
</affiliation>
</author>
<author><name sortKey="Weber, G" sort="Weber, G" uniqKey="Weber G" first="G." last="Weber">G. Weber</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Molecular Medicine, Karolinska Hospital, Clinical Genetics Unit, CMM L8:02</s1>
<s2>171 76 Stockholm</s2>
<s3>SWE</s3>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Suède</country>
</affiliation>
</author>
<author><name sortKey="Kytol, S" sort="Kytol, S" uniqKey="Kytol S" first="S." last="Kytöl">S. Kytöl</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Molecular Medicine, Endocrine tumour unit, Karolinska Hospital, CMM L8:01</s1>
<s2>171 76 Stockholm</s2>
<s3>SWE</s3>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>Suède</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Clinical Genetics, Oulu University Hospital</s1>
<s2>Oulu</s2>
<s3>FIN</s3>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
</affiliation>
</author>
<author><name sortKey="Teh, B T" sort="Teh, B T" uniqKey="Teh B" first="B. T." last="Teh">B. T. Teh</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Molecular Medicine, Endocrine tumour unit, Karolinska Hospital, CMM L8:01</s1>
<s2>171 76 Stockholm</s2>
<s3>SWE</s3>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>Suède</country>
</affiliation>
</author>
<author><name sortKey="Farnebo, F" sort="Farnebo, F" uniqKey="Farnebo F" first="F." last="Farnebo">F. Farnebo</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Molecular Medicine, Endocrine tumour unit, Karolinska Hospital, CMM L8:01</s1>
<s2>171 76 Stockholm</s2>
<s3>SWE</s3>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>Suède</country>
</affiliation>
</author>
<author><name sortKey="Phelan, C" sort="Phelan, C" uniqKey="Phelan C" first="C." last="Phelan">C. Phelan</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Molecular Medicine, Endocrine tumour unit, Karolinska Hospital, CMM L8:01</s1>
<s2>171 76 Stockholm</s2>
<s3>SWE</s3>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>Suède</country>
</affiliation>
</author>
<author><name sortKey="Hayward, N" sort="Hayward, N" uniqKey="Hayward N" first="N." last="Hayward">N. Hayward</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Queensland Institute of Medical Research, Human Genetics Laboratory</s1>
<s2> Herston 4029, Queensland</s2>
<s3>AUS</s3>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Australie</country>
</affiliation>
</author>
<author><name sortKey="Larsson, C" sort="Larsson, C" uniqKey="Larsson C" first="C." last="Larsson">C. Larsson</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Molecular Medicine, Endocrine tumour unit, Karolinska Hospital, CMM L8:01</s1>
<s2>171 76 Stockholm</s2>
<s3>SWE</s3>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>Suède</country>
</affiliation>
</author>
<author><name sortKey="Pannett, A A J" sort="Pannett, A A J" uniqKey="Pannett A" first="A. A. J." last="Pannett">A. A. J. Pannett</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>MRC Molecular Endocrinology Group, MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road</s1>
<s2>London W12 0NN</s2>
<s3>GBR</s3>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author><name sortKey="Forbes, S A" sort="Forbes, S A" uniqKey="Forbes S" first="S. A." last="Forbes">S. A. Forbes</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>MRC Molecular Endocrinology Group, MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road</s1>
<s2>London W12 0NN</s2>
<s3>GBR</s3>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author><name sortKey="Bassett, J H D" sort="Bassett, J H D" uniqKey="Bassett J" first="J. H. D." last="Bassett">J. H. D. Bassett</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>MRC Molecular Endocrinology Group, MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road</s1>
<s2>London W12 0NN</s2>
<s3>GBR</s3>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author><name sortKey="Thakker, R V" sort="Thakker, R V" uniqKey="Thakker R" first="R. V." last="Thakker">R. V. Thakker</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>MRC Molecular Endocrinology Group, MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road</s1>
<s2>London W12 0NN</s2>
<s3>GBR</s3>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Human molecular genetics</title>
<title level="j" type="abbreviated">Hum. mol. genet.</title>
<idno type="ISSN">0964-6906</idno>
<imprint><date when="1997">1997</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Human molecular genetics</title>
<title level="j" type="abbreviated">Hum. mol. genet.</title>
<idno type="ISSN">0964-6906</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Chromosome C11</term>
<term>Gene expression</term>
<term>Genetic mapping</term>
<term>Genetics</term>
<term>Human</term>
<term>Hyperparathyroidism</term>
<term>Multiple endocrine neoplasia type I</term>
<term>Mutation</term>
<term>Tumor suppressor gene</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Homme</term>
<term>Génétique</term>
<term>Chromosome C11</term>
<term>Carte génétique</term>
<term>Mutation</term>
<term>Gène suppresseur tumeur</term>
<term>Expression génique</term>
<term>Hyperparathyroïdie</term>
<term>Polyadénomatose endocrinienne I</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
<term>Génétique</term>
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<front><div type="abstract" xml:lang="en">Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterised by tumours of the parathyroids, pancreas and anterior pituitary that represents one of the familial cancer syndromes. The MEN1 locus has been previously localised to chromosome 11q13, and a <300 kb gene-rich region flanked centromerically by PYGM and telomerically by D11S1783 defined by combined meiotic and tumour deletion mapping studies. Two candidate genes, ZFM1 and PPP2RSB, from this region have been previously excluded, and in order to identify additional candidate genes we used a BAC to isolate cDNAs from a bovine parathyroid cDNA library by direct selection. One of the novel genes that we identified, SCG2, proved to be identical to the recently published MEN1 gene, which is likely to be a tumour suppressor gene. The SCG2 transcript was 2.9 kb in all tissues with an additional 4.2 kb transcript also being present in the pancreas and thymus. Mutational analysis of SCG2 in 10 unrelated MEN1 families identified one polymorphism and nine different heterozygous mutations (one missense, four non-sense, one insertional and three deletional frameshifts) that segregated with the disease, hence providing an independent confirmation for the identification of the MEN1 gene.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0964-6906</s0>
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</fA03>
<fA05><s2>6</s2>
</fA05>
<fA06><s2>7</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Identification of the multiple endocrine neoplasia type 1 (MEN1) gene</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>LEMMENS (I.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>VAN DE VEN (W. J. M.)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>KAS (K.)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>ZHANG (C. X.)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>GIRAUD (S.)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>WAUTOT (V.)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>BUISSON (N.)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>DE WITTE (K.)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>SALANDRE (J.)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>LENOIR (G.)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>PUGEAT (M.)</s1>
</fA11>
<fA11 i1="12" i2="1"><s1>CALENDER (A.)</s1>
</fA11>
<fA11 i1="13" i2="1"><s1>PARENTE (F.)</s1>
</fA11>
<fA11 i1="14" i2="1"><s1>QUINCEY (D.)</s1>
</fA11>
<fA11 i1="15" i2="1"><s1>GAUDRAY (P.)</s1>
</fA11>
<fA11 i1="16" i2="1"><s1>DE WIT (M. J.)</s1>
</fA11>
<fA11 i1="17" i2="1"><s1>LIPS (C. J. M.)</s1>
</fA11>
<fA11 i1="18" i2="1"><s1>HÖPPENER (J. W. M.)</s1>
</fA11>
<fA11 i1="19" i2="1"><s1>KHODAEI (S.)</s1>
</fA11>
<fA11 i1="20" i2="1"><s1>GRANT (A. L.)</s1>
</fA11>
<fA11 i1="21" i2="1"><s1>WEBER (G.)</s1>
</fA11>
<fA11 i1="22" i2="1"><s1>KYTÖLÄ (S.)</s1>
</fA11>
<fA11 i1="23" i2="1"><s1>TEH (B. T.)</s1>
</fA11>
<fA11 i1="24" i2="1"><s1>FARNEBO (F.)</s1>
</fA11>
<fA11 i1="25" i2="1"><s1>PHELAN (C.)</s1>
</fA11>
<fA11 i1="26" i2="1"><s1>HAYWARD (N.)</s1>
</fA11>
<fA11 i1="27" i2="1"><s1>LARSSON (C.)</s1>
</fA11>
<fA11 i1="28" i2="1"><s1>PANNETT (A. A. J.)</s1>
</fA11>
<fA11 i1="29" i2="1"><s1>FORBES (S. A.)</s1>
</fA11>
<fA11 i1="30" i2="1"><s1>BASSETT (J. H. D.)</s1>
</fA11>
<fA11 i1="31" i2="1"><s1>THAKKER (R. V.)</s1>
</fA11>
<fA14 i1="01"><s1>Laboratory for Molecular Oncology and Flanders Interuniversity Institute for Biotechnology, Center for Human Genetics, KU Leuven, Herestraat 49</s1>
<s2>3000 Leuven</s2>
<s3>BEL</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>GENEM 1 (Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1): Genetic Unit, Hôpital Edouard Herriot,</s1>
<s2>Lyon</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>GENEM 1 (Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1):Laboratory of genetics and cancer, CNRS UMR5641, Medical University Claude Bernard Lyon 1</s1>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>GENEM 1 (Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1):Endocrinology Unit, Hôpital de l'Antiquaille</s1>
<s2>69 Lyon</s2>
<s3>FRA</s3>
<sZ>11 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Instabilité et altérations des Génomes, UNSA/CNRS UMR 6549, Avenue de Valombrose</s1>
<s2>06107 Nice</s2>
<s3>FRA</s3>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Utrecht University Hospital, Departments of Internal Medicine and Pathology, H04-313, PO Box 85500, Heidelberglaan 100</s1>
<s2>3508 GA Utrecht</s2>
<s3>NLD</s3>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>Department of Molecular Medicine, Karolinska Hospital, Clinical Genetics Unit, CMM L8:02</s1>
<s2>171 76 Stockholm</s2>
<s3>SWE</s3>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</fA14>
<fA14 i1="08"><s1>Department of Molecular Medicine, Endocrine tumour unit, Karolinska Hospital, CMM L8:01</s1>
<s2>171 76 Stockholm</s2>
<s3>SWE</s3>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>27 aut.</sZ>
</fA14>
<fA14 i1="09"><s1>Department of Clinical Genetics, Oulu University Hospital</s1>
<s2>Oulu</s2>
<s3>FIN</s3>
<sZ>22 aut.</sZ>
</fA14>
<fA14 i1="10"><s1>Queensland Institute of Medical Research, Human Genetics Laboratory</s1>
<s2> Herston 4029, Queensland</s2>
<s3>AUS</s3>
<sZ>26 aut.</sZ>
</fA14>
<fA14 i1="11"><s1>MRC Molecular Endocrinology Group, MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road</s1>
<s2>London W12 0NN</s2>
<s3>GBR</s3>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
<sZ>31 aut.</sZ>
</fA14>
<fA17 i1="01" i2="1"><s1>The European Consortium on MEN1</s1>
<s3>INC</s3>
</fA17>
<fA20><s1>1177-1183</s1>
</fA20>
<fA21><s1>1997</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
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<s2>22540</s2>
<s5>354000067240670270</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 1997 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>30 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>97-0389518</s0>
</fA47>
<fA60><s1>P</s1>
<s3>C</s3>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Human molecular genetics</s0>
</fA64>
<fA66 i1="01"><s0>GBR</s0>
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<fC01 i1="01" l="ENG"><s0>Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterised by tumours of the parathyroids, pancreas and anterior pituitary that represents one of the familial cancer syndromes. The MEN1 locus has been previously localised to chromosome 11q13, and a <300 kb gene-rich region flanked centromerically by PYGM and telomerically by D11S1783 defined by combined meiotic and tumour deletion mapping studies. Two candidate genes, ZFM1 and PPP2RSB, from this region have been previously excluded, and in order to identify additional candidate genes we used a BAC to isolate cDNAs from a bovine parathyroid cDNA library by direct selection. One of the novel genes that we identified, SCG2, proved to be identical to the recently published MEN1 gene, which is likely to be a tumour suppressor gene. The SCG2 transcript was 2.9 kb in all tissues with an additional 4.2 kb transcript also being present in the pancreas and thymus. Mutational analysis of SCG2 in 10 unrelated MEN1 families identified one polymorphism and nine different heterozygous mutations (one missense, four non-sense, one insertional and three deletional frameshifts) that segregated with the disease, hence providing an independent confirmation for the identification of the MEN1 gene.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B21C02</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Homme</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Human</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Hombre</s0>
<s5>01</s5>
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<fC03 i1="02" i2="X" l="FRE"><s0>Génétique</s0>
<s5>02</s5>
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<s5>02</s5>
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<fC03 i1="02" i2="X" l="SPA"><s0>Genética</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Chromosome C11</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Chromosome C11</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Cromosoma C11</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Carte génétique</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Genetic mapping</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Mapa genético</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Mutation</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Mutation</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Mutación</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Gène suppresseur tumeur</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Tumor suppressor gene</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Gen supresor tumor</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Expression génique</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Gene expression</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Expresión genética</s0>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Hyperparathyroïdie</s0>
<s5>14</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Hyperparathyroidism</s0>
<s5>14</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Hiperparatiroidismo</s0>
<s5>14</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Polyadénomatose endocrinienne I</s0>
<s5>15</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Multiple endocrine neoplasia type I</s0>
<s5>15</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Neoplasia endocrina múltiple tipo I</s0>
<s5>15</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Endocrinopathie</s0>
<s5>47</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Endocrinopathy</s0>
<s5>47</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Endocrinopatía</s0>
<s5>47</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Parathyroïde pathologie</s0>
<s5>48</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Parathyroid diseases</s0>
<s5>48</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Paratiroides patología</s0>
<s5>48</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Tumeur bénigne</s0>
<s5>58</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Benign neoplasm</s0>
<s5>58</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Tumor benigno</s0>
<s5>58</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Maladie héréditaire</s0>
<s5>59</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Genetic disease</s0>
<s5>59</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Enfermedad hereditaria</s0>
<s5>59</s5>
</fC07>
<fN21><s1>237</s1>
</fN21>
</pA>
</standard>
</inist>
</record>

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   |texte=   Identification of the multiple endocrine neoplasia type 1 (MEN1) gene
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	Serveur d'exploration sur les relations entre la France et l'Australie
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Identification of the multiple endocrine neoplasia type 1 (MEN1) gene

Identification of the multiple endocrine neoplasia type 1 (MEN1) gene

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