The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length
Identifieur interne : 005E05 ( PascalFrancis/Curation ); précédent : 005E04; suivant : 005E06The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length
Auteurs : Mark M. Iles [Royaume-Uni] ; D. Timothy Bishop [Royaume-Uni] ; John C. Taylor [Royaume-Uni] ; Nicholas K. Hayward [Australie] ; Myriam Brossard [France] ; Anne E. Cust [Australie] ; Alison M. Dunning [Royaume-Uni] ; Jeffrey E. Lee [États-Unis] ; Eric K. Moses [Australie] ; Lars A. Akslen [Norvège] ; Per A. Andresen [Norvège] ; Marie-Françoise Avril [France] ; Esther Azizi [Israël] ; Giovanna Bianchi Scarra [Italie] ; Kevin M. Brown [États-Unis] ; Tadeusz Debniak ; David E. Elder ; Eitan Friedman [Israël, Italie] ; Paola Ghiorzo [Italie] ; Elizabeth M. Gillanders ; Alisa M. Goldstein [États-Unis] ; Nelleke A. Gruis ; Johan Hansson ; Mark Harland [Royaume-Uni] ; Per Helsing [Norvège] ; Marko Hocevar ; Veronica Höiom ; Christian Ingvar ; Peter A. Kanetsky ; Mariateresa Landi [États-Unis] ; Julie Lang ; G. Mark Lathrop ; Jan Lubinski ; Rona M. Mackie ; Nicholas G. Martin [Australie] ; Anders Molven [Norvège] ; Grant W. Montgomery [Australie] ; Srdjan Novakovic ; H Kan Olsson ; Susana Puig ; Joan Anton Puig-Butille ; Graham L. Radford-Smith [Australie] ; Juliette Randerson-Mor [Royaume-Uni] ; Nienke Van Der Stoep ; Remco Van Doorn ; David C. Whiteman [Australie] ; Stuart Macgregor [Australie] ; Karen A. Pooley ; Sarah V. Ward [Australie] ; Graham J. Mann ; Christopher I. Amos ; Paul D. P. Pharaoh [Royaume-Uni] ; Florence Demenais [France] ; Matthew H. Law [Australie] ; Julia A. Newton Bishop ; Jennifer H. Barrett [Royaume-Uni]Source :
- Journal of the National Cancer Institute [ 0027-8874 ] ; 2014.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Génétique, Association.
English descriptors
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Abstract
Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11108 case patients and 13933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (P = 8.92×10-9, two-sided) with melanoma risk.
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Elder</name></author><author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name><affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Oncogenics Unit, Tel Hashomer, Sackler Faculty of Medicine</s1><s2>Tel Aviv</s2><s3>ISR</s3><sZ>13 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Israël</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Department of Internal Medicine and Medical Specialties, University of Genoa</s1><s2>Genoa</s2><s3>ITA</s3><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Italie</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="24"><s1>Laboratory of Genetics of Rare Hereditary Cancers, San Martino-IST Research Hospital</s1><s2>Genoa</s2><s3>ITA</s3><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Ghiorzo, Paola" sort="Ghiorzo, Paola" uniqKey="Ghiorzo P" first="Paola" last="Ghiorzo">Paola Ghiorzo</name><affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Department of Internal Medicine and Medical Specialties, University of Genoa</s1><s2>Genoa</s2><s3>ITA</s3><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Italie</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="24"><s1>Laboratory of Genetics of Rare Hereditary Cancers, San Martino-IST Research Hospital</s1><s2>Genoa</s2><s3>ITA</s3><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Gillanders, Elizabeth M" sort="Gillanders, Elizabeth M" uniqKey="Gillanders E" first="Elizabeth M." last="Gillanders">Elizabeth M. Gillanders</name></author><author><name sortKey="Goldstein, Alisa M" sort="Goldstein, Alisa M" uniqKey="Goldstein A" first="Alisa M." last="Goldstein">Alisa M. Goldstein</name><affiliation wicri:level="1"><inist:fA14 i1="25"><s1>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health</s1><s2>Bethesda, MD</s2><s3>USA</s3><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Gruis, Nelleke A" sort="Gruis, Nelleke A" uniqKey="Gruis N" first="Nelleke A." last="Gruis">Nelleke A. Gruis</name></author><author><name sortKey="Hansson, Johan" sort="Hansson, Johan" uniqKey="Hansson J" first="Johan" last="Hansson">Johan Hansson</name></author><author><name sortKey="Harland, Mark" sort="Harland, Mark" uniqKey="Harland M" first="Mark" last="Harland">Mark Harland</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds Cancer Research UK Centre, University of Leeds</s1><s2>Leeds</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>43 aut.</sZ><sZ>56 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Helsing, Per" sort="Helsing, Per" uniqKey="Helsing P" first="Per" last="Helsing">Per Helsing</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Department of Dermatology, Oslo University Hospital</s1><s2>Rikshospitalet, Oslo</s2><s3>NOR</s3><sZ>25 aut.</sZ></inist:fA14><country>Norvège</country></affiliation></author><author><name sortKey="Hocevar, Marko" sort="Hocevar, Marko" uniqKey="Hocevar M" first="Marko" last="Hocevar">Marko Hocevar</name></author><author><name sortKey="Hoiom, Veronica" sort="Hoiom, Veronica" uniqKey="Hoiom V" first="Veronica" last="Höiom">Veronica Höiom</name></author><author><name sortKey="Ingvar, Christian" sort="Ingvar, Christian" uniqKey="Ingvar C" first="Christian" last="Ingvar">Christian Ingvar</name></author><author><name sortKey="Kanetsky, Peter A" sort="Kanetsky, Peter A" uniqKey="Kanetsky P" first="Peter A." last="Kanetsky">Peter A. Kanetsky</name></author><author><name sortKey="Landi, Mariateresa" sort="Landi, Mariateresa" uniqKey="Landi M" first="Mariateresa" last="Landi">Mariateresa Landi</name><affiliation wicri:level="1"><inist:fA14 i1="25"><s1>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health</s1><s2>Bethesda, MD</s2><s3>USA</s3><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Lang, Julie" sort="Lang, Julie" uniqKey="Lang J" first="Julie" last="Lang">Julie Lang</name></author><author><name sortKey="Lathrop, G Mark" sort="Lathrop, G Mark" uniqKey="Lathrop G" first="G. Mark" last="Lathrop">G. Mark Lathrop</name></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name></author><author><name sortKey="Mackie, Rona M" sort="Mackie, Rona M" uniqKey="Mackie R" first="Rona M." last="Mackie">Rona M. Mackie</name></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Genetic Epidemiology, QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>35 aut.</sZ></inist:fA14><country>Australie</country></affiliation></author><author><name sortKey="Molven, Anders" sort="Molven, Anders" uniqKey="Molven A" first="Anders" last="Molven">Anders Molven</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen</s1><s2>Bergen</s2><s3>NOR</s3><sZ>36 aut.</sZ></inist:fA14><country>Norvège</country></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Molecular Epidemiology, QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>37 aut.</sZ></inist:fA14><country>Australie</country></affiliation></author><author><name sortKey="Novakovic, Srdjan" sort="Novakovic, Srdjan" uniqKey="Novakovic S" first="Srdjan" last="Novakovic">Srdjan Novakovic</name></author><author><name sortKey="Olsson, H Kan" sort="Olsson, H Kan" uniqKey="Olsson H" first="H Kan" last="Olsson">H Kan Olsson</name></author><author><name sortKey="Puig, Susana" sort="Puig, Susana" uniqKey="Puig S" first="Susana" last="Puig">Susana Puig</name></author><author><name sortKey="Puig Butille, Joan Anton" sort="Puig Butille, Joan Anton" uniqKey="Puig Butille J" first="Joan Anton" last="Puig-Butille">Joan Anton Puig-Butille</name></author><author><name sortKey="Radford Smith, Graham L" sort="Radford Smith, Graham L" uniqKey="Radford Smith G" first="Graham L." last="Radford-Smith">Graham L. Radford-Smith</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Inflammatory Bowel Diseases Laboratory, QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>42 aut.</sZ></inist:fA14><country>Australie</country></affiliation></author><author><name sortKey="Randerson Mor, Juliette" sort="Randerson Mor, Juliette" uniqKey="Randerson Mor J" first="Juliette" last="Randerson-Mor">Juliette Randerson-Mor</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds Cancer Research UK Centre, University of Leeds</s1><s2>Leeds</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>43 aut.</sZ><sZ>56 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Van Der Stoep, Nienke" sort="Van Der Stoep, Nienke" uniqKey="Van Der Stoep N" first="Nienke" last="Van Der Stoep">Nienke Van Der Stoep</name></author><author><name sortKey="Van Doorn, Remco" sort="Van Doorn, Remco" uniqKey="Van Doorn R" first="Remco" last="Van Doorn">Remco Van Doorn</name></author><author><name sortKey="Whiteman, David C" sort="Whiteman, David C" uniqKey="Whiteman D" first="David C." last="Whiteman">David C. Whiteman</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Cancer Control Group, QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>46 aut.</sZ></inist:fA14><country>Australie</country></affiliation></author><author><name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Statistical Genetics, QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>47 aut.</sZ><sZ>54 aut.</sZ></inist:fA14><country>Australie</country></affiliation></author><author><name sortKey="Pooley, Karen A" sort="Pooley, Karen A" uniqKey="Pooley K" first="Karen A." last="Pooley">Karen A. Pooley</name></author><author><name sortKey="Ward, Sarah V" sort="Ward, Sarah V" uniqKey="Ward S" first="Sarah V." last="Ward">Sarah V. Ward</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Centre for Genetic Origins of Health and Disease, Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia</s1><s2>Crawley</s2><s3>AUS</s3><sZ>9 aut.</sZ><sZ>49 aut.</sZ></inist:fA14><country>Australie</country></affiliation></author><author><name sortKey="Mann, Graham J" sort="Mann, Graham J" uniqKey="Mann G" first="Graham J." last="Mann">Graham J. Mann</name></author><author><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I." last="Amos">Christopher I. Amos</name></author><author><name sortKey="Pharaoh, Paul D P" sort="Pharaoh, Paul D P" uniqKey="Pharaoh P" first="Paul D. P." last="Pharaoh">Paul D. P. Pharaoh</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Oncology, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Demenais, Florence" sort="Demenais, Florence" uniqKey="Demenais F" first="Florence" last="Demenais">Florence Demenais</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>INSERM, UMR-946, Genetic Variation and Human Diseases Unit</s1><s2>Paris</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>53 aut.</sZ></inist:fA14><country>France</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie</s1><s2>Paris</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>53 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Law, Matthew H" sort="Law, Matthew H" uniqKey="Law M" first="Matthew H." last="Law">Matthew H. Law</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Statistical Genetics, QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>47 aut.</sZ><sZ>54 aut.</sZ></inist:fA14><country>Australie</country></affiliation></author><author><name sortKey="Newton Bishop, Julia A" sort="Newton Bishop, Julia A" uniqKey="Newton Bishop J" first="Julia A." last="Newton Bishop">Julia A. Newton Bishop</name></author><author><name sortKey="Barrett, Jennifer H" sort="Barrett, Jennifer H" uniqKey="Barrett J" first="Jennifer H." last="Barrett">Jennifer H. Barrett</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds Cancer Research UK Centre, University of Leeds</s1><s2>Leeds</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>43 aut.</sZ><sZ>56 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">15-0030914</idno><date when="2014">2014</date><idno type="stanalyst">PASCAL 15-0030914 INIST</idno><idno type="RBID">Pascal:15-0030914</idno><idno type="wicri:Area/PascalFrancis/Corpus">000048</idno><idno type="wicri:Area/PascalFrancis/Curation">005E05</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length</title><author><name sortKey="Iles, Mark M" sort="Iles, Mark M" uniqKey="Iles M" first="Mark M." last="Iles">Mark M. Iles</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds Cancer Research UK Centre, University of Leeds</s1><s2>Leeds</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>43 aut.</sZ><sZ>56 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Bishop, D Timothy" sort="Bishop, D Timothy" uniqKey="Bishop D" first="D. Timothy" last="Bishop">D. Timothy Bishop</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds Cancer Research UK Centre, University of Leeds</s1><s2>Leeds</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>43 aut.</sZ><sZ>56 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Taylor, John C" sort="Taylor, John C" uniqKey="Taylor J" first="John C." last="Taylor">John C. Taylor</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds Cancer Research UK Centre, University of Leeds</s1><s2>Leeds</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>43 aut.</sZ><sZ>56 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Hayward, Nicholas K" sort="Hayward, Nicholas K" uniqKey="Hayward N" first="Nicholas K." last="Hayward">Nicholas K. Hayward</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Oncogenomics, QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>4 aut.</sZ></inist:fA14><country>Australie</country></affiliation></author><author><name sortKey="Brossard, Myriam" sort="Brossard, Myriam" uniqKey="Brossard M" first="Myriam" last="Brossard">Myriam Brossard</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>INSERM, UMR-946, Genetic Variation and Human Diseases Unit</s1><s2>Paris</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>53 aut.</sZ></inist:fA14><country>France</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie</s1><s2>Paris</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>53 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Cust, Anne E" sort="Cust, Anne E" uniqKey="Cust A" first="Anne E." last="Cust">Anne E. Cust</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Cancer Epidemiology and Services Research, Sydney School of Public Health, University of Sydney</s1><s3>AUS</s3><sZ>6 aut.</sZ></inist:fA14><country>Australie</country></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Oncology, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Lee, Jeffrey E" sort="Lee, Jeffrey E" uniqKey="Lee J" first="Jeffrey E." last="Lee">Jeffrey E. Lee</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Surgical Oncology, University of Texas MD Anderson Cancer Center</s1><s2>Houston, TX</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Moses, Eric K" sort="Moses, Eric K" uniqKey="Moses E" first="Eric K." last="Moses">Eric K. Moses</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Centre for Genetic Origins of Health and Disease, Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia</s1><s2>Crawley</s2><s3>AUS</s3><sZ>9 aut.</sZ><sZ>49 aut.</sZ></inist:fA14><country>Australie</country></affiliation></author><author><name sortKey="Akslen, Lars A" sort="Akslen, Lars A" uniqKey="Akslen L" first="Lars A." last="Akslen">Lars A. Akslen</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Centre for Cancer Biomarkers CCBIO, Department of Clinical Medicine, University of Bergen</s1><s2>Bergen</s2><s3>NOR</s3><sZ>10 aut.</sZ></inist:fA14><country>Norvège</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Pathology, Haukeland University Hospital</s1><s2>Bergen</s2><s3>NOR</s3><sZ>10 aut.</sZ></inist:fA14><country>Norvège</country></affiliation></author><author><name sortKey="Andresen, Per A" sort="Andresen, Per A" uniqKey="Andresen P" first="Per A." last="Andresen">Per A. Andresen</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Department of Pathology, Molecular Pathology, Oslo University Hospital</s1><s2>Rikshospitalet, Oslo</s2><s3>NOR</s3><sZ>11 aut.</sZ></inist:fA14><country>Norvège</country></affiliation></author><author><name sortKey="Avril, Marie Francoise" sort="Avril, Marie Francoise" uniqKey="Avril M" first="Marie-Françoise" last="Avril">Marie-Françoise Avril</name><affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Assistance Publique-Hôpitaux de Paris, Hôpital Cochin, Service de Dermatologie, Université Paris Descartes</s1><s2>Paris</s2><s3>FRA</s3><sZ>12 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Azizi, Esther" sort="Azizi, Esther" uniqKey="Azizi E" first="Esther" last="Azizi">Esther Azizi</name><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Department of Dermatology, Tel Hashomer, Sackler Faculty of Medicine</s1><s2>Tel Aviv</s2><s3>ISR</s3><sZ>13 aut.</sZ></inist:fA14><country>Israël</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Oncogenics Unit, Tel Hashomer, Sackler Faculty of Medicine</s1><s2>Tel Aviv</s2><s3>ISR</s3><sZ>13 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Israël</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="22"><s1>Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine</s1><s2>Tel Aviv</s2><s3>ISR</s3><sZ>13 aut.</sZ></inist:fA14><country>Israël</country></affiliation></author><author><name sortKey="Scarra, Giovanna Bianchi" sort="Scarra, Giovanna Bianchi" uniqKey="Scarra G" first="Giovanna Bianchi" last="Scarra">Giovanna Bianchi Scarra</name><affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Department of Internal Medicine and Medical Specialties, University of Genoa</s1><s2>Genoa</s2><s3>ITA</s3><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Italie</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="24"><s1>Laboratory of Genetics of Rare Hereditary Cancers, San Martino-IST Research Hospital</s1><s2>Genoa</s2><s3>ITA</s3><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Brown, Kevin M" sort="Brown, Kevin M" uniqKey="Brown K" first="Kevin M." last="Brown">Kevin M. Brown</name><affiliation wicri:level="1"><inist:fA14 i1="25"><s1>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health</s1><s2>Bethesda, MD</s2><s3>USA</s3><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Debniak, Tadeusz" sort="Debniak, Tadeusz" uniqKey="Debniak T" first="Tadeusz" last="Debniak">Tadeusz Debniak</name></author><author><name sortKey="Elder, David E" sort="Elder, David E" uniqKey="Elder D" first="David E." last="Elder">David E. Elder</name></author><author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name><affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Oncogenics Unit, Tel Hashomer, Sackler Faculty of Medicine</s1><s2>Tel Aviv</s2><s3>ISR</s3><sZ>13 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Israël</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Department of Internal Medicine and Medical Specialties, University of Genoa</s1><s2>Genoa</s2><s3>ITA</s3><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Italie</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="24"><s1>Laboratory of Genetics of Rare Hereditary Cancers, San Martino-IST Research Hospital</s1><s2>Genoa</s2><s3>ITA</s3><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Ghiorzo, Paola" sort="Ghiorzo, Paola" uniqKey="Ghiorzo P" first="Paola" last="Ghiorzo">Paola Ghiorzo</name><affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Department of Internal Medicine and Medical Specialties, University of Genoa</s1><s2>Genoa</s2><s3>ITA</s3><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Italie</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="24"><s1>Laboratory of Genetics of Rare Hereditary Cancers, San Martino-IST Research Hospital</s1><s2>Genoa</s2><s3>ITA</s3><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Gillanders, Elizabeth M" sort="Gillanders, Elizabeth M" uniqKey="Gillanders E" first="Elizabeth M." last="Gillanders">Elizabeth M. Gillanders</name></author><author><name sortKey="Goldstein, Alisa M" sort="Goldstein, Alisa M" uniqKey="Goldstein A" first="Alisa M." last="Goldstein">Alisa M. Goldstein</name><affiliation wicri:level="1"><inist:fA14 i1="25"><s1>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health</s1><s2>Bethesda, MD</s2><s3>USA</s3><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Gruis, Nelleke A" sort="Gruis, Nelleke A" uniqKey="Gruis N" first="Nelleke A." last="Gruis">Nelleke A. Gruis</name></author><author><name sortKey="Hansson, Johan" sort="Hansson, Johan" uniqKey="Hansson J" first="Johan" last="Hansson">Johan Hansson</name></author><author><name sortKey="Harland, Mark" sort="Harland, Mark" uniqKey="Harland M" first="Mark" last="Harland">Mark Harland</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds Cancer Research UK Centre, University of Leeds</s1><s2>Leeds</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>43 aut.</sZ><sZ>56 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Helsing, Per" sort="Helsing, Per" uniqKey="Helsing P" first="Per" last="Helsing">Per Helsing</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Department of Dermatology, Oslo University Hospital</s1><s2>Rikshospitalet, Oslo</s2><s3>NOR</s3><sZ>25 aut.</sZ></inist:fA14><country>Norvège</country></affiliation></author><author><name sortKey="Hocevar, Marko" sort="Hocevar, Marko" uniqKey="Hocevar M" first="Marko" last="Hocevar">Marko Hocevar</name></author><author><name sortKey="Hoiom, Veronica" sort="Hoiom, Veronica" uniqKey="Hoiom V" first="Veronica" last="Höiom">Veronica Höiom</name></author><author><name sortKey="Ingvar, Christian" sort="Ingvar, Christian" uniqKey="Ingvar C" first="Christian" last="Ingvar">Christian Ingvar</name></author><author><name sortKey="Kanetsky, Peter A" sort="Kanetsky, Peter A" uniqKey="Kanetsky P" first="Peter A." last="Kanetsky">Peter A. Kanetsky</name></author><author><name sortKey="Landi, Mariateresa" sort="Landi, Mariateresa" uniqKey="Landi M" first="Mariateresa" last="Landi">Mariateresa Landi</name><affiliation wicri:level="1"><inist:fA14 i1="25"><s1>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health</s1><s2>Bethesda, MD</s2><s3>USA</s3><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Lang, Julie" sort="Lang, Julie" uniqKey="Lang J" first="Julie" last="Lang">Julie Lang</name></author><author><name sortKey="Lathrop, G Mark" sort="Lathrop, G Mark" uniqKey="Lathrop G" first="G. Mark" last="Lathrop">G. Mark Lathrop</name></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name></author><author><name sortKey="Mackie, Rona M" sort="Mackie, Rona M" uniqKey="Mackie R" first="Rona M." last="Mackie">Rona M. Mackie</name></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Genetic Epidemiology, QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>35 aut.</sZ></inist:fA14><country>Australie</country></affiliation></author><author><name sortKey="Molven, Anders" sort="Molven, Anders" uniqKey="Molven A" first="Anders" last="Molven">Anders Molven</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen</s1><s2>Bergen</s2><s3>NOR</s3><sZ>36 aut.</sZ></inist:fA14><country>Norvège</country></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Molecular Epidemiology, QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>37 aut.</sZ></inist:fA14><country>Australie</country></affiliation></author><author><name sortKey="Novakovic, Srdjan" sort="Novakovic, Srdjan" uniqKey="Novakovic S" first="Srdjan" last="Novakovic">Srdjan Novakovic</name></author><author><name sortKey="Olsson, H Kan" sort="Olsson, H Kan" uniqKey="Olsson H" first="H Kan" last="Olsson">H Kan Olsson</name></author><author><name sortKey="Puig, Susana" sort="Puig, Susana" uniqKey="Puig S" first="Susana" last="Puig">Susana Puig</name></author><author><name sortKey="Puig Butille, Joan Anton" sort="Puig Butille, Joan Anton" uniqKey="Puig Butille J" first="Joan Anton" last="Puig-Butille">Joan Anton Puig-Butille</name></author><author><name sortKey="Radford Smith, Graham L" sort="Radford Smith, Graham L" uniqKey="Radford Smith G" first="Graham L." last="Radford-Smith">Graham L. Radford-Smith</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Inflammatory Bowel Diseases Laboratory, QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>42 aut.</sZ></inist:fA14><country>Australie</country></affiliation></author><author><name sortKey="Randerson Mor, Juliette" sort="Randerson Mor, Juliette" uniqKey="Randerson Mor J" first="Juliette" last="Randerson-Mor">Juliette Randerson-Mor</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds Cancer Research UK Centre, University of Leeds</s1><s2>Leeds</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>43 aut.</sZ><sZ>56 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Van Der Stoep, Nienke" sort="Van Der Stoep, Nienke" uniqKey="Van Der Stoep N" first="Nienke" last="Van Der Stoep">Nienke Van Der Stoep</name></author><author><name sortKey="Van Doorn, Remco" sort="Van Doorn, Remco" uniqKey="Van Doorn R" first="Remco" last="Van Doorn">Remco Van Doorn</name></author><author><name sortKey="Whiteman, David C" sort="Whiteman, David C" uniqKey="Whiteman D" first="David C." last="Whiteman">David C. Whiteman</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Cancer Control Group, QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>46 aut.</sZ></inist:fA14><country>Australie</country></affiliation></author><author><name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Statistical Genetics, QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>47 aut.</sZ><sZ>54 aut.</sZ></inist:fA14><country>Australie</country></affiliation></author><author><name sortKey="Pooley, Karen A" sort="Pooley, Karen A" uniqKey="Pooley K" first="Karen A." last="Pooley">Karen A. Pooley</name></author><author><name sortKey="Ward, Sarah V" sort="Ward, Sarah V" uniqKey="Ward S" first="Sarah V." last="Ward">Sarah V. Ward</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Centre for Genetic Origins of Health and Disease, Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia</s1><s2>Crawley</s2><s3>AUS</s3><sZ>9 aut.</sZ><sZ>49 aut.</sZ></inist:fA14><country>Australie</country></affiliation></author><author><name sortKey="Mann, Graham J" sort="Mann, Graham J" uniqKey="Mann G" first="Graham J." last="Mann">Graham J. Mann</name></author><author><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I." last="Amos">Christopher I. Amos</name></author><author><name sortKey="Pharaoh, Paul D P" sort="Pharaoh, Paul D P" uniqKey="Pharaoh P" first="Paul D. P." last="Pharaoh">Paul D. P. Pharaoh</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Oncology, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Demenais, Florence" sort="Demenais, Florence" uniqKey="Demenais F" first="Florence" last="Demenais">Florence Demenais</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>INSERM, UMR-946, Genetic Variation and Human Diseases Unit</s1><s2>Paris</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>53 aut.</sZ></inist:fA14><country>France</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie</s1><s2>Paris</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>53 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Law, Matthew H" sort="Law, Matthew H" uniqKey="Law M" first="Matthew H." last="Law">Matthew H. Law</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Statistical Genetics, QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>47 aut.</sZ><sZ>54 aut.</sZ></inist:fA14><country>Australie</country></affiliation></author><author><name sortKey="Newton Bishop, Julia A" sort="Newton Bishop, Julia A" uniqKey="Newton Bishop J" first="Julia A." last="Newton Bishop">Julia A. Newton Bishop</name></author><author><name sortKey="Barrett, Jennifer H" sort="Barrett, Jennifer H" uniqKey="Barrett J" first="Jennifer H." last="Barrett">Jennifer H. Barrett</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds Cancer Research UK Centre, University of Leeds</s1><s2>Leeds</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>43 aut.</sZ><sZ>56 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author></analytic><series><title level="j" type="main">Journal of the National Cancer Institute</title><title level="j" type="abbreviated">J. Natl. Cancer Inst.</title><idno type="ISSN">0027-8874</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of the National Cancer Institute</title><title level="j" type="abbreviated">J. Natl. Cancer Inst.</title><idno type="ISSN">0027-8874</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Association</term><term>Cancerology</term><term>Gene</term><term>Genetics</term><term>Length</term><term>Malignant melanoma</term><term>Risk</term><term>Risk factor</term><term>Telomere</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Mélanome malin</term><term>Facteur risque</term><term>Risque</term><term>Gène</term><term>Génétique</term><term>Association</term><term>Télomère</term><term>Longueur</term><term>Cancérologie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Génétique</term><term>Association</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11108 case patients and 13933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (P = 8.92×10<sup>-9</sup>, two-sided) with melanoma risk.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0027-8874</s0></fA01><fA03 i2="1"><s0>J. Natl. Cancer Inst.</s0></fA03><fA05><s2>106</s2></fA05><fA06><s2>10</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length</s1></fA08><fA11 i1="01" i2="1"><s1>ILES (Mark M.)</s1></fA11><fA11 i1="02" i2="1"><s1>BISHOP (D. Timothy)</s1></fA11><fA11 i1="03" i2="1"><s1>TAYLOR (John C.)</s1></fA11><fA11 i1="04" i2="1"><s1>HAYWARD (Nicholas K.)</s1></fA11><fA11 i1="05" i2="1"><s1>BROSSARD (Myriam)</s1></fA11><fA11 i1="06" i2="1"><s1>CUST (Anne E.)</s1></fA11><fA11 i1="07" i2="1"><s1>DUNNING (Alison M.)</s1></fA11><fA11 i1="08" i2="1"><s1>LEE (Jeffrey E.)</s1></fA11><fA11 i1="09" i2="1"><s1>MOSES (Eric K.)</s1></fA11><fA11 i1="10" i2="1"><s1>AKSLEN (Lars A.)</s1></fA11><fA11 i1="11" i2="1"><s1>ANDRESEN (Per A.)</s1></fA11><fA11 i1="12" i2="1"><s1>AVRIL (Marie-Françoise)</s1></fA11><fA11 i1="13" i2="1"><s1>AZIZI (Esther)</s1></fA11><fA11 i1="14" i2="1"><s1>SCARRA (Giovanna Bianchi)</s1></fA11><fA11 i1="15" i2="1"><s1>BROWN (Kevin M.)</s1></fA11><fA11 i1="16" i2="1"><s1>DEBNIAK (Tadeusz)</s1></fA11><fA11 i1="17" i2="1"><s1>ELDER (David E.)</s1></fA11><fA11 i1="18" i2="1"><s1>FRIEDMAN (Eitan)</s1></fA11><fA11 i1="19" i2="1"><s1>GHIORZO (Paola)</s1></fA11><fA11 i1="20" i2="1"><s1>GILLANDERS (Elizabeth M.)</s1></fA11><fA11 i1="21" i2="1"><s1>GOLDSTEIN (Alisa M.)</s1></fA11><fA11 i1="22" i2="1"><s1>GRUIS (Nelleke A.)</s1></fA11><fA11 i1="23" i2="1"><s1>HANSSON (Johan)</s1></fA11><fA11 i1="24" i2="1"><s1>HARLAND (Mark)</s1></fA11><fA11 i1="25" i2="1"><s1>HELSING (Per)</s1></fA11><fA11 i1="26" i2="1"><s1>HOCEVAR (Marko)</s1></fA11><fA11 i1="27" i2="1"><s1>HÖIOM (Veronica)</s1></fA11><fA11 i1="28" i2="1"><s1>INGVAR (Christian)</s1></fA11><fA11 i1="29" i2="1"><s1>KANETSKY (Peter A.)</s1></fA11><fA11 i1="30" i2="1"><s1>LANDI (Mariateresa)</s1></fA11><fA11 i1="31" i2="1"><s1>LANG (Julie)</s1></fA11><fA11 i1="32" i2="1"><s1>LATHROP (G. Mark)</s1></fA11><fA11 i1="33" i2="1"><s1>LUBINSKI (Jan)</s1></fA11><fA11 i1="34" i2="1"><s1>MACKIE (Rona M.)</s1></fA11><fA11 i1="35" i2="1"><s1>MARTIN (Nicholas G.)</s1></fA11><fA11 i1="36" i2="1"><s1>MOLVEN (Anders)</s1></fA11><fA11 i1="37" i2="1"><s1>MONTGOMERY (Grant W.)</s1></fA11><fA11 i1="38" i2="1"><s1>NOVAKOVIC (Srdjan)</s1></fA11><fA11 i1="39" i2="1"><s1>OLSSON (Håkan)</s1></fA11><fA11 i1="40" i2="1"><s1>PUIG (Susana)</s1></fA11><fA11 i1="41" i2="1"><s1>PUIG-BUTILLE (Joan Anton)</s1></fA11><fA11 i1="42" i2="1"><s1>RADFORD-SMITH (Graham L.)</s1></fA11><fA11 i1="43" i2="1"><s1>RANDERSON-MOR (Juliette)</s1></fA11><fA11 i1="44" i2="1"><s1>VAN DER STOEP (Nienke)</s1></fA11><fA11 i1="45" i2="1"><s1>VAN DOORN (Remco)</s1></fA11><fA11 i1="46" i2="1"><s1>WHITEMAN (David C.)</s1></fA11><fA11 i1="47" i2="1"><s1>MACGREGOR (Stuart)</s1></fA11><fA11 i1="48" i2="1"><s1>POOLEY (Karen A.)</s1></fA11><fA11 i1="49" i2="1"><s1>WARD (Sarah V.)</s1></fA11><fA11 i1="50" i2="1"><s1>MANN (Graham J.)</s1></fA11><fA11 i1="51" i2="1"><s1>AMOS (Christopher I.)</s1></fA11><fA11 i1="52" i2="1"><s1>PHARAOH (Paul D. P.)</s1></fA11><fA11 i1="53" i2="1"><s1>DEMENAIS (Florence)</s1></fA11><fA11 i1="54" i2="1"><s1>LAW (Matthew H.)</s1></fA11><fA11 i1="55" i2="1"><s1>NEWTON BISHOP (Julia A.)</s1></fA11><fA11 i1="56" i2="1"><s1>BARRETT (Jennifer H.)</s1></fA11><fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds Cancer Research UK Centre, University of Leeds</s1><s2>Leeds</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>43 aut.</sZ><sZ>56 aut.</sZ></fA14><fA14 i1="02"><s1>Oncogenomics, QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>4 aut.</sZ></fA14><fA14 i1="03"><s1>Genetic Epidemiology, QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>35 aut.</sZ></fA14><fA14 i1="04"><s1>Inflammatory Bowel Diseases Laboratory, QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>42 aut.</sZ></fA14><fA14 i1="05"><s1>Cancer Control Group, QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>46 aut.</sZ></fA14><fA14 i1="06"><s1>Statistical Genetics, QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>47 aut.</sZ><sZ>54 aut.</sZ></fA14><fA14 i1="07"><s1>Molecular Epidemiology, QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>37 aut.</sZ></fA14><fA14 i1="08"><s1>INSERM, UMR-946, Genetic Variation and Human Diseases Unit</s1><s2>Paris</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>53 aut.</sZ></fA14><fA14 i1="09"><s1>Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie</s1><s2>Paris</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>53 aut.</sZ></fA14><fA14 i1="10"><s1>Cancer Epidemiology and Services Research, Sydney School of Public Health, University of Sydney</s1><s3>AUS</s3><sZ>6 aut.</sZ></fA14><fA14 i1="11"><s1>Department of Oncology, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>52 aut.</sZ></fA14><fA14 i1="12"><s1>Department of Surgical Oncology, University of Texas MD Anderson Cancer Center</s1><s2>Houston, TX</s2><s3>USA</s3><sZ>8 aut.</sZ></fA14><fA14 i1="13"><s1>Centre for Genetic Origins of Health and Disease, Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia</s1><s2>Crawley</s2><s3>AUS</s3><sZ>9 aut.</sZ><sZ>49 aut.</sZ></fA14><fA14 i1="14"><s1>Centre for Cancer Biomarkers CCBIO, Department of Clinical Medicine, University of Bergen</s1><s2>Bergen</s2><s3>NOR</s3><sZ>10 aut.</sZ></fA14><fA14 i1="15"><s1>Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen</s1><s2>Bergen</s2><s3>NOR</s3><sZ>36 aut.</sZ></fA14><fA14 i1="16"><s1>Department of Pathology, Haukeland University Hospital</s1><s2>Bergen</s2><s3>NOR</s3><sZ>10 aut.</sZ></fA14><fA14 i1="17"><s1>Department of Pathology, Molecular Pathology, Oslo University Hospital</s1><s2>Rikshospitalet, Oslo</s2><s3>NOR</s3><sZ>11 aut.</sZ></fA14><fA14 i1="18"><s1>Department of Dermatology, Oslo University Hospital</s1><s2>Rikshospitalet, Oslo</s2><s3>NOR</s3><sZ>25 aut.</sZ></fA14><fA14 i1="19"><s1>Assistance Publique-Hôpitaux de Paris, Hôpital Cochin, Service de Dermatologie, Université Paris Descartes</s1><s2>Paris</s2><s3>FRA</s3><sZ>12 aut.</sZ></fA14><fA14 i1="20"><s1>Department of Dermatology, Tel Hashomer, Sackler Faculty of Medicine</s1><s2>Tel Aviv</s2><s3>ISR</s3><sZ>13 aut.</sZ></fA14><fA14 i1="21"><s1>Oncogenics Unit, Tel Hashomer, Sackler Faculty of Medicine</s1><s2>Tel Aviv</s2><s3>ISR</s3><sZ>13 aut.</sZ><sZ>18 aut.</sZ></fA14><fA14 i1="22"><s1>Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine</s1><s2>Tel Aviv</s2><s3>ISR</s3><sZ>13 aut.</sZ></fA14><fA14 i1="23"><s1>Department of Internal Medicine and Medical Specialties, University of Genoa</s1><s2>Genoa</s2><s3>ITA</s3><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></fA14><fA14 i1="24"><s1>Laboratory of Genetics of Rare Hereditary Cancers, San Martino-IST Research Hospital</s1><s2>Genoa</s2><s3>ITA</s3><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></fA14><fA14 i1="25"><s1>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health</s1><s2>Bethesda, MD</s2><s3>USA</s3><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>30 aut.</sZ></fA14><fA17 i1="01" i2="1"><s1>IBD investigators, AMFS Investigators, QMEGA and QTWIN Investigators, SDH Study Group, GenoMEL Consortium</s1><s3>INC</s3></fA17><fA20><s2>267.1-267.5</s2></fA20><fA21><s1>2014</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>3364</s2><s5>354000508282850210</s5></fA43><fA44><s0>0000</s0><s1>© 2015 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>24 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>15-0030914</s0></fA47><fA60><s1>P</s1><s3>CC</s3></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Journal of the National Cancer Institute</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11108 case patients and 13933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (P = 8.92×10<sup>-9</sup>, two-sided) with melanoma risk.</s0></fC01><fC02 i1="01" i2="X"><s0>002B04C</s0></fC02><fC02 i1="02" i2="X"><s0>002B08A</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Mélanome malin</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Malignant melanoma</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Melanoma maligno</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Facteur risque</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Risk factor</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Factor riesgo</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Risque</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Risk</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Riesgo</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Gène</s0><s5>05</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Gene</s0><s5>05</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Gen</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Génétique</s0><s5>06</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Genetics</s0><s5>06</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Genética</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Association</s0><s5>08</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Association</s0><s5>08</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Asociación</s0><s5>08</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Télomère</s0><s5>09</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Telomere</s0><s5>09</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Telómero</s0><s5>09</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Longueur</s0><s5>11</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Length</s0><s5>11</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Longitud</s0><s5>11</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Cancérologie</s0><s5>12</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Cancerology</s0><s5>12</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Cancerología</s0><s5>12</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Tumeur maligne</s0><s2>NM</s2><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Malignant tumor</s0><s2>NM</s2><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Tumor maligno</s0><s2>NM</s2><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Cancer</s0><s2>NM</s2></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Cancer</s0><s2>NM</s2></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Cáncer</s0><s2>NM</s2></fC07><fN21><s1>047</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist></record>Pour manipuler ce document sous Unix (Dilib)
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