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Mass treatment to eliminate tuberculosis from an island population

Identifieur interne : 005B53 ( PascalFrancis/Curation ); précédent : 005B52; suivant : 005B54

Mass treatment to eliminate tuberculosis from an island population

Auteurs : P. C. Hill [Nouvelle-Zélande] ; C. Dye [Suisse] ; K. Viney ; K. Tabutoa [Suisse, Kiribati] ; T. Kienene [Kiribati] ; K. Bissell [France, Nouvelle-Zélande] ; B. G. Williams [Afrique du Sud] ; R. Zachariah [Belgique] ; B. J. Marais [Australie] ; A. D. Harries [France, Royaume-Uni]

Source :

RBID : Pascal:14-0196387

Descripteurs français

English descriptors

Abstract

SETTING: The global target of tuberculosis (TB) elimination by 2050 requires new approaches. Active case finding plus mass prophylactic treatment has been disappointing. We consider mass full anti-tuberculosis treatment as an approach to TB elimination in Kiribati, a Pacific Island nation, with a persistent epidemic of high TB incidence. OBJECTIVE: To construct a mathematical model to predict whether mass treatment with a full course of anti-tuberculosis drugs might eliminate TB from the defined population of the Republic of Kiribati. METHODS: We constructed a seven-state compartmental model of the life cycle of Mycobacterium tuberculosis in which active TB disease arises from the progression of infection, reinfection, reactivation and relapse, while distinguishing infectious from non-infectious disease. We evaluated the effects of 5-yearly mass treatment using a range of parameter values to generate outcomes in uncertainty analysis. RESULTS: Assuming population-wide treatment effectiveness for latent tuberculous infection and active TB of ≥90%, annual TB incidence is expected to fall sharply at each 5-yearly round of treatment, approaching elimination in two decades. The model showed that the incidence rate is sensitive to the relapse rate after successful treatment of TB. CONCLUSION: Mass treatment may help to eliminate TB, at least for discrete or geographically isolated populations.
pA  
A01 01  1    @0 1027-3719
A03   1    @0 Int. j. tuberc. lung dis.
A05       @2 18
A06       @2 8
A08 01  1  ENG  @1 Mass treatment to eliminate tuberculosis from an island population
A11 01  1    @1 HILL (P. C.)
A11 02  1    @1 DYE (C.)
A11 03  1    @1 VINEY (K.)
A11 04  1    @1 TABUTOA (K.)
A11 05  1    @1 KIENENE (T.)
A11 06  1    @1 BISSELL (K.)
A11 07  1    @1 WILLIAMS (B. G.)
A11 08  1    @1 ZACHARIAH (R.)
A11 09  1    @1 MARAIS (B. J.)
A11 10  1    @1 HARRIES (A. D.)
A14 01      @1 Centre for International Health, Department of Preventive and Social Medicine, Faculty of Medicine, University of Otago @2 Dunedin @3 NZL @Z 1 aut.
A14 02      @1 HIV/AIDS, Tuberculosis, Malaria & Neglected Tropical Diseases Cluster, World Health Organization @2 Geneva @3 CHE @Z 2 aut. @Z 4 aut.
A14 03      @1 Public Health Division, Secretariat of the Pacific Community @2 Noumea @3 NCL @Z 3 aut.
A14 04      @1 National Tuberculosis Control Programme, Ministry of Health and Medical Services @3 KIR @Z 4 aut. @Z 5 aut.
A14 05      @1 International Union Against Tuberculosis and Lung Disease @2 Paris @3 FRA @Z 6 aut. @Z 10 aut.
A14 06      @1 School of Population Health, University of Auckland @2 Auckland @3 NZL @Z 6 aut.
A14 07      @1 South African Centre for Epidemiological Modelling and Analysis @2 Cape Town @3 ZAF @Z 7 aut.
A14 08      @1 Médecins Sans Frontières, Brussels Operational Centre @2 Luxembourg @3 BEL @Z 8 aut.
A14 09      @1 Sydney Emerging Infectious Disease and Biosecurity Institute and Centre for Research Excellence in Tuberculosis, University of Sydney @2 Sydney, New South Wales @3 AUS @Z 9 aut.
A14 10      @1 London School of Hygiene & Tropical Medicine @2 London @3 GBR @Z 10 aut.
A20       @1 899-904
A21       @1 2014
A23 01      @0 ENG
A43 01      @1 INIST @2 26450 @5 354000504815800050
A44       @0 0000 @1 © 2014 INIST-CNRS. All rights reserved.
A45       @0 17 ref.
A47 01  1    @0 14-0196387
A60       @1 P
A61       @0 A
A64 01  1    @0 The International journal of tuberculosis and lung disease
A66 01      @0 FRA
C01 01    ENG  @0 SETTING: The global target of tuberculosis (TB) elimination by 2050 requires new approaches. Active case finding plus mass prophylactic treatment has been disappointing. We consider mass full anti-tuberculosis treatment as an approach to TB elimination in Kiribati, a Pacific Island nation, with a persistent epidemic of high TB incidence. OBJECTIVE: To construct a mathematical model to predict whether mass treatment with a full course of anti-tuberculosis drugs might eliminate TB from the defined population of the Republic of Kiribati. METHODS: We constructed a seven-state compartmental model of the life cycle of Mycobacterium tuberculosis in which active TB disease arises from the progression of infection, reinfection, reactivation and relapse, while distinguishing infectious from non-infectious disease. We evaluated the effects of 5-yearly mass treatment using a range of parameter values to generate outcomes in uncertainty analysis. RESULTS: Assuming population-wide treatment effectiveness for latent tuberculous infection and active TB of ≥90%, annual TB incidence is expected to fall sharply at each 5-yearly round of treatment, approaching elimination in two decades. The model showed that the incidence rate is sensitive to the relapse rate after successful treatment of TB. CONCLUSION: Mass treatment may help to eliminate TB, at least for discrete or geographically isolated populations.
C02 01  X    @0 002B11
C02 02  X    @0 002B05B02O
C03 01  X  FRE  @0 Tuberculose @5 01
C03 01  X  ENG  @0 Tuberculosis @5 01
C03 01  X  SPA  @0 Tuberculosis @5 01
C03 02  X  FRE  @0 Pathologie de l'appareil respiratoire @5 02
C03 02  X  ENG  @0 Respiratory disease @5 02
C03 02  X  SPA  @0 Aparato respiratorio patología @5 02
C03 03  X  FRE  @0 Campagne de masse @5 09
C03 03  X  ENG  @0 Mass campaign @5 09
C03 03  X  SPA  @0 Campaña de población @5 09
C03 04  X  FRE  @0 Traitement @5 10
C03 04  X  ENG  @0 Treatment @5 10
C03 04  X  SPA  @0 Tratamiento @5 10
C03 05  X  FRE  @0 Ile @5 11
C03 05  X  ENG  @0 Island @5 11
C03 05  X  SPA  @0 Isla @5 11
C03 06  X  FRE  @0 Homme @5 12
C03 06  X  ENG  @0 Human @5 12
C03 06  X  SPA  @0 Hombre @5 12
C03 07  X  FRE  @0 Population @5 13
C03 07  X  ENG  @0 Population @5 13
C03 07  X  SPA  @0 Población @5 13
C03 08  X  FRE  @0 Elimination @5 14
C03 08  X  ENG  @0 Elimination @5 14
C03 08  X  SPA  @0 Eliminación @5 14
C07 01  X  FRE  @0 Mycobactériose
C07 01  X  ENG  @0 Mycobacterial infection
C07 01  X  SPA  @0 Micobacteriosis
C07 02  X  FRE  @0 Bactériose
C07 02  X  ENG  @0 Bacteriosis
C07 02  X  SPA  @0 Bacteriosis
C07 03  X  FRE  @0 Infection
C07 03  X  ENG  @0 Infection
C07 03  X  SPA  @0 Infección
N21       @1 244
N44 01      @1 OTO
N82       @1 OTO

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K. Viney
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<div type="abstract" xml:lang="en">SETTING: The global target of tuberculosis (TB) elimination by 2050 requires new approaches. Active case finding plus mass prophylactic treatment has been disappointing. We consider mass full anti-tuberculosis treatment as an approach to TB elimination in Kiribati, a Pacific Island nation, with a persistent epidemic of high TB incidence. OBJECTIVE: To construct a mathematical model to predict whether mass treatment with a full course of anti-tuberculosis drugs might eliminate TB from the defined population of the Republic of Kiribati. METHODS: We constructed a seven-state compartmental model of the life cycle of Mycobacterium tuberculosis in which active TB disease arises from the progression of infection, reinfection, reactivation and relapse, while distinguishing infectious from non-infectious disease. We evaluated the effects of 5-yearly mass treatment using a range of parameter values to generate outcomes in uncertainty analysis. RESULTS: Assuming population-wide treatment effectiveness for latent tuberculous infection and active TB of ≥90%, annual TB incidence is expected to fall sharply at each 5-yearly round of treatment, approaching elimination in two decades. The model showed that the incidence rate is sensitive to the relapse rate after successful treatment of TB. CONCLUSION: Mass treatment may help to eliminate TB, at least for discrete or geographically isolated populations.</div>
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<fA11 i1="04" i2="1">
<s1>TABUTOA (K.)</s1>
</fA11>
<fA11 i1="05" i2="1">
<s1>KIENENE (T.)</s1>
</fA11>
<fA11 i1="06" i2="1">
<s1>BISSELL (K.)</s1>
</fA11>
<fA11 i1="07" i2="1">
<s1>WILLIAMS (B. G.)</s1>
</fA11>
<fA11 i1="08" i2="1">
<s1>ZACHARIAH (R.)</s1>
</fA11>
<fA11 i1="09" i2="1">
<s1>MARAIS (B. J.)</s1>
</fA11>
<fA11 i1="10" i2="1">
<s1>HARRIES (A. D.)</s1>
</fA11>
<fA14 i1="01">
<s1>Centre for International Health, Department of Preventive and Social Medicine, Faculty of Medicine, University of Otago</s1>
<s2>Dunedin</s2>
<s3>NZL</s3>
<sZ>1 aut.</sZ>
</fA14>
<fA14 i1="02">
<s1>HIV/AIDS, Tuberculosis, Malaria & Neglected Tropical Diseases Cluster, World Health Organization</s1>
<s2>Geneva</s2>
<s3>CHE</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="03">
<s1>Public Health Division, Secretariat of the Pacific Community</s1>
<s2>Noumea</s2>
<s3>NCL</s3>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="04">
<s1>National Tuberculosis Control Programme, Ministry of Health and Medical Services</s1>
<s3>KIR</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="05">
<s1>International Union Against Tuberculosis and Lung Disease</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="06">
<s1>School of Population Health, University of Auckland</s1>
<s2>Auckland</s2>
<s3>NZL</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="07">
<s1>South African Centre for Epidemiological Modelling and Analysis</s1>
<s2>Cape Town</s2>
<s3>ZAF</s3>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="08">
<s1>Médecins Sans Frontières, Brussels Operational Centre</s1>
<s2>Luxembourg</s2>
<s3>BEL</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="09">
<s1>Sydney Emerging Infectious Disease and Biosecurity Institute and Centre for Research Excellence in Tuberculosis, University of Sydney</s1>
<s2>Sydney, New South Wales</s2>
<s3>AUS</s3>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="10">
<s1>London School of Hygiene & Tropical Medicine</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>10 aut.</sZ>
</fA14>
<fA20>
<s1>899-904</s1>
</fA20>
<fA21>
<s1>2014</s1>
</fA21>
<fA23 i1="01">
<s0>ENG</s0>
</fA23>
<fA43 i1="01">
<s1>INIST</s1>
<s2>26450</s2>
<s5>354000504815800050</s5>
</fA43>
<fA44>
<s0>0000</s0>
<s1>© 2014 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45>
<s0>17 ref.</s0>
</fA45>
<fA47 i1="01" i2="1">
<s0>14-0196387</s0>
</fA47>
<fA60>
<s1>P</s1>
</fA60>
<fA61>
<s0>A</s0>
</fA61>
<fA64 i1="01" i2="1">
<s0>The International journal of tuberculosis and lung disease</s0>
</fA64>
<fA66 i1="01">
<s0>FRA</s0>
</fA66>
<fC01 i1="01" l="ENG">
<s0>SETTING: The global target of tuberculosis (TB) elimination by 2050 requires new approaches. Active case finding plus mass prophylactic treatment has been disappointing. We consider mass full anti-tuberculosis treatment as an approach to TB elimination in Kiribati, a Pacific Island nation, with a persistent epidemic of high TB incidence. OBJECTIVE: To construct a mathematical model to predict whether mass treatment with a full course of anti-tuberculosis drugs might eliminate TB from the defined population of the Republic of Kiribati. METHODS: We constructed a seven-state compartmental model of the life cycle of Mycobacterium tuberculosis in which active TB disease arises from the progression of infection, reinfection, reactivation and relapse, while distinguishing infectious from non-infectious disease. We evaluated the effects of 5-yearly mass treatment using a range of parameter values to generate outcomes in uncertainty analysis. RESULTS: Assuming population-wide treatment effectiveness for latent tuberculous infection and active TB of ≥90%, annual TB incidence is expected to fall sharply at each 5-yearly round of treatment, approaching elimination in two decades. The model showed that the incidence rate is sensitive to the relapse rate after successful treatment of TB. CONCLUSION: Mass treatment may help to eliminate TB, at least for discrete or geographically isolated populations.</s0>
</fC01>
<fC02 i1="01" i2="X">
<s0>002B11</s0>
</fC02>
<fC02 i1="02" i2="X">
<s0>002B05B02O</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE">
<s0>Tuberculose</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG">
<s0>Tuberculosis</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA">
<s0>Tuberculosis</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE">
<s0>Pathologie de l'appareil respiratoire</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG">
<s0>Respiratory disease</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA">
<s0>Aparato respiratorio patología</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE">
<s0>Campagne de masse</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG">
<s0>Mass campaign</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA">
<s0>Campaña de población</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE">
<s0>Traitement</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG">
<s0>Treatment</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA">
<s0>Tratamiento</s0>
<s5>10</s5>
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<fC03 i1="05" i2="X" l="FRE">
<s0>Ile</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG">
<s0>Island</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA">
<s0>Isla</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE">
<s0>Homme</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG">
<s0>Human</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA">
<s0>Hombre</s0>
<s5>12</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE">
<s0>Population</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG">
<s0>Population</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA">
<s0>Población</s0>
<s5>13</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE">
<s0>Elimination</s0>
<s5>14</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG">
<s0>Elimination</s0>
<s5>14</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA">
<s0>Eliminación</s0>
<s5>14</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE">
<s0>Mycobactériose</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG">
<s0>Mycobacterial infection</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA">
<s0>Micobacteriosis</s0>
</fC07>
<fC07 i1="02" i2="X" l="FRE">
<s0>Bactériose</s0>
</fC07>
<fC07 i1="02" i2="X" l="ENG">
<s0>Bacteriosis</s0>
</fC07>
<fC07 i1="02" i2="X" l="SPA">
<s0>Bacteriosis</s0>
</fC07>
<fC07 i1="03" i2="X" l="FRE">
<s0>Infection</s0>
</fC07>
<fC07 i1="03" i2="X" l="ENG">
<s0>Infection</s0>
</fC07>
<fC07 i1="03" i2="X" l="SPA">
<s0>Infección</s0>
</fC07>
<fN21>
<s1>244</s1>
</fN21>
<fN44 i1="01">
<s1>OTO</s1>
</fN44>
<fN82>
<s1>OTO</s1>
</fN82>
</pA>
</standard>
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