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Updated Treatment Algorithm of Pulmonary Arterial Hypertension

Identifieur interne : 005877 ( PascalFrancis/Curation ); précédent : 005876; suivant : 005878

Updated Treatment Algorithm of Pulmonary Arterial Hypertension

Auteurs : Nazzareno Galie [Italie] ; Paul A. Corris [Royaume-Uni] ; Adaani Frost [États-Unis] ; Reda E. Girgis [États-Unis] ; John Granton [Canada] ; ZHI CHENG JING [République populaire de Chine] ; Walter Klepetko [Autriche] ; Michael D. Mcgoon [États-Unis] ; Vallerie V. Mclaughlin [États-Unis] ; Ioana R. Preston [États-Unis] ; Lewis J. Rubin [États-Unis] ; Julio Sandoval [Mexique] ; Werner Seeger [Allemagne] ; Anne Keogh [Australie]

Source :

RBID : Pascal:14-0036896

Descripteurs français

English descriptors

Abstract

The demands on a pulmonary arterial hypertension (PAH) treatment algorithm are multiple and in some ways conflicting. The treatment algorithm usually includes different types of recommendations with varying degrees of scientific evidence. In addition, the algorithm is required to be comprehensive but not too complex, informative yet simple and straightforward. The type of information in the treatment algorithm are heterogeneous including clinical, hemodynamic, medical, interventional, pharmacological and regulatory recommendations. Stakeholders (or users) including physicians from various specialties and with variable expertise in PAH, nurses, patients and patients' associations, healthcare providers, regulatory agencies and industry are often interested in the PAH treatment algorithm for different reasons. These are the considerable challenges faced when proposing appropriate updates to the current evidence-based treatment algorithm. The current treatment algorithm may be divided into 3 main areas: 1) general measures, supportive therapy, referral strategy, acute vasoreactivity testing and chronic treatment with calcium channel blockers; 2) initial therapy with approved PAH drugs; and 3) clinical response to the initial therapy, combination therapy, balloon atrial septostomy, and lung transplantation. All three sections will be revisited highlighting information newly available in the past 5 years and proposing updates where appropriate. The European Society of Cardiology grades of recommendation and levels of evidence will be adopted to rank the proposed treatments.
pA  
A01 01  1    @0 0735-1097
A02 01      @0 JACCDI
A03   1    @0 J. Am. Coll. Cardiol.
A05       @2 62
A06       @2 25 @3 SUPD
A08 01  1  ENG  @1 Updated Treatment Algorithm of Pulmonary Arterial Hypertension
A09 01  1  ENG  @1 Updates in Pulmonary Hypertension: Proceedings of the 5th World Symposium on Pulmonary Hypertension
A11 01  1    @1 GALIE (Nazzareno)
A11 02  1    @1 CORRIS (Paul A.)
A11 03  1    @1 FROST (Adaani)
A11 04  1    @1 GIRGIS (Reda E.)
A11 05  1    @1 GRANTON (John)
A11 06  1    @1 ZHI CHENG JING
A11 07  1    @1 KLEPETKO (Walter)
A11 08  1    @1 MCGOON (Michael D.)
A11 09  1    @1 MCLAUGHLIN (Vallerie V.)
A11 10  1    @1 PRESTON (Ioana R.)
A11 11  1    @1 RUBIN (Lewis J.)
A11 12  1    @1 SANDOVAL (Julio)
A11 13  1    @1 SEEGER (Werner)
A11 14  1    @1 KEOGH (Anne)
A12 01  1    @1 GALIE (Nazzareno) @9 ed.
A12 02  1    @1 SIMONNEAU (Gerald) @9 ed.
A14 01      @1 Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Bologna University Hospital @2 Bologna @3 ITA @Z 1 aut.
A14 02      @1 Institute of Cellular Medicine Newcastle University and The Newcastle Hospitals NHS Foundation Trust @2 Newcastle @3 GBR @Z 2 aut.
A14 03      @1 Baylor College of Medicine @2 Houston, Texas @3 USA @Z 3 aut.
A14 04      @1 Michigan State University, College of Human Medicine @2 Grand Rapids, Michigan @3 USA @Z 4 aut.
A14 05      @1 Division of Respirology, University of Toronto @2 Toronto @3 CAN @Z 5 aut.
A14 06      @1 Fu Wai Hospital & National Center for Cardiovascular Disease Peking Union Medical College and Chinese Academy of Medical Science @2 Beijing @3 CHN @Z 6 aut.
A14 07      @1 Department of Thoracic Surgery, Medical University Vienna/Vienna General Hospital @2 Vienna @3 AUT @Z 7 aut.
A14 08      @1 Cardiovascular Diseases, Mayo Clinic @2 Rochester, Minnesota @3 USA @Z 8 aut.
A14 09      @1 Cardiovascular Medicine, The University of Michigan @2 Ann Arbor, Michigan @3 USA @Z 9 aut.
A14 10      @1 Pulmonary, Critical Care and Sleep Division, Tufts Medical Center, Tufts University School of Medicine @2 Boston, Massachusetts @3 USA @Z 10 aut.
A14 11      @1 Medical School, University of California, San Diego @2 La Jolla, California @3 USA @Z 11 aut.
A14 12      @1 Clinical Research, National Institute of Cardiology of Mexico @2 Mexico City @3 MEX @Z 12 aut.
A14 13      @1 Max Planck Institute for Heart and Lung Research, Universities of Giessen and Marburg Lung Center @2 Giessen/Bad Nauheim @3 DEU @Z 13 aut.
A14 14      @1 Heart Transplant Unit, St Vincent's Hospital @2 Sydney @3 AUS @Z 14 aut.
A15 01      @1 Department of Experimental, Diagnostic and Specialty Medicine-DIMES @2 Bologna @3 ITA @Z 1 aut.
A15 02      @1 Assistance Publique-Hôpitaux de Paris, Service de Pneumologie, Hôpital Universitaire de Bicêtre, Université Paris-Sud, Laboratoire d'excellence en Recherche sur le Médicament et Innovation Thérapeutique, INSERM, Unité 999 @2 Le Kremlin-Bicêtre, Paris @3 FRA @Z 2 aut.
A20       @2 D60-D72
A21       @1 2013
A23 01      @0 ENG
A43 01      @1 INIST @2 20098 @5 354000500747320070
A44       @0 0000 @1 © 2014 INIST-CNRS. All rights reserved.
A45       @0 86 ref.
A47 01  1    @0 14-0036896
A60       @1 P @2 C
A61       @0 A
A64 01  1    @0 Journal of the American College of Cardiology
A66 01      @0 USA
C01 01    ENG  @0 The demands on a pulmonary arterial hypertension (PAH) treatment algorithm are multiple and in some ways conflicting. The treatment algorithm usually includes different types of recommendations with varying degrees of scientific evidence. In addition, the algorithm is required to be comprehensive but not too complex, informative yet simple and straightforward. The type of information in the treatment algorithm are heterogeneous including clinical, hemodynamic, medical, interventional, pharmacological and regulatory recommendations. Stakeholders (or users) including physicians from various specialties and with variable expertise in PAH, nurses, patients and patients' associations, healthcare providers, regulatory agencies and industry are often interested in the PAH treatment algorithm for different reasons. These are the considerable challenges faced when proposing appropriate updates to the current evidence-based treatment algorithm. The current treatment algorithm may be divided into 3 main areas: 1) general measures, supportive therapy, referral strategy, acute vasoreactivity testing and chronic treatment with calcium channel blockers; 2) initial therapy with approved PAH drugs; and 3) clinical response to the initial therapy, combination therapy, balloon atrial septostomy, and lung transplantation. All three sections will be revisited highlighting information newly available in the past 5 years and proposing updates where appropriate. The European Society of Cardiology grades of recommendation and levels of evidence will be adopted to rank the proposed treatments.
C02 01  X    @0 002B12A
C02 02  X    @0 002B11C
C03 01  X  FRE  @0 Hypertension artérielle pulmonaire @5 01
C03 01  X  ENG  @0 Pulmonary hypertension @5 01
C03 01  X  SPA  @0 Hipertensión arterial pulmonar @5 01
C03 02  X  FRE  @0 Pathologie de l'appareil circulatoire @5 02
C03 02  X  ENG  @0 Cardiovascular disease @5 02
C03 02  X  SPA  @0 Aparato circulatorio patología @5 02
C03 03  X  FRE  @0 Traitement @5 09
C03 03  X  ENG  @0 Treatment @5 09
C03 03  X  SPA  @0 Tratamiento @5 09
C03 04  X  FRE  @0 Algorithme @5 10
C03 04  X  ENG  @0 Algorithm @5 10
C03 04  X  SPA  @0 Algoritmo @5 10
C03 05  X  FRE  @0 Arbre décision @5 11
C03 05  X  ENG  @0 Decision tree @5 11
C03 05  X  SPA  @0 Arbol decisión @5 11
C03 06  X  FRE  @0 Artère @5 12
C03 06  X  ENG  @0 Artery @5 12
C03 06  X  SPA  @0 Arteria @5 12
C03 07  X  FRE  @0 Appareil circulatoire @5 13
C03 07  X  ENG  @0 Circulatory system @5 13
C03 07  X  SPA  @0 Aparato circulatorio @5 13
C03 08  X  FRE  @0 Cardiologie @5 14
C03 08  X  ENG  @0 Cardiology @5 14
C03 08  X  SPA  @0 Cardiología @5 14
C07 01  X  FRE  @0 Pathologie de l'appareil respiratoire @5 37
C07 01  X  ENG  @0 Respiratory disease @5 37
C07 01  X  SPA  @0 Aparato respiratorio patología @5 37
C07 02  X  FRE  @0 Vaisseau sanguin @5 38
C07 02  X  ENG  @0 Blood vessel @5 38
C07 02  X  SPA  @0 Vaso sanguíneo @5 38
N21       @1 041
N44 01      @1 OTO
N82       @1 OTO
pR  
A30 01  1  ENG  @1 WSPH World Symposium on Pulmonary Hypertension @2 5 @3 Nice FRA @4 2013-02-27

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Le document en format XML

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<name sortKey="Granton, John" sort="Granton, John" uniqKey="Granton J" first="John" last="Granton">John Granton</name>
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<name sortKey="Mcgoon, Michael D" sort="Mcgoon, Michael D" uniqKey="Mcgoon M" first="Michael D." last="Mcgoon">Michael D. Mcgoon</name>
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<name sortKey="Mclaughlin, Vallerie V" sort="Mclaughlin, Vallerie V" uniqKey="Mclaughlin V" first="Vallerie V." last="Mclaughlin">Vallerie V. Mclaughlin</name>
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<s1>Cardiovascular Medicine, The University of Michigan</s1>
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<name sortKey="Preston, Ioana R" sort="Preston, Ioana R" uniqKey="Preston I" first="Ioana R." last="Preston">Ioana R. Preston</name>
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<s1>Pulmonary, Critical Care and Sleep Division, Tufts Medical Center, Tufts University School of Medicine</s1>
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<s3>USA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
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</affiliation>
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<name sortKey="Rubin, Lewis J" sort="Rubin, Lewis J" uniqKey="Rubin L" first="Lewis J." last="Rubin">Lewis J. Rubin</name>
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<inist:fA14 i1="11">
<s1>Medical School, University of California, San Diego</s1>
<s2>La Jolla, California</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
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<author>
<name sortKey="Sandoval, Julio" sort="Sandoval, Julio" uniqKey="Sandoval J" first="Julio" last="Sandoval">Julio Sandoval</name>
<affiliation wicri:level="1">
<inist:fA14 i1="12">
<s1>Clinical Research, National Institute of Cardiology of Mexico</s1>
<s2>Mexico City</s2>
<s3>MEX</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Mexique</country>
</affiliation>
</author>
<author>
<name sortKey="Seeger, Werner" sort="Seeger, Werner" uniqKey="Seeger W" first="Werner" last="Seeger">Werner Seeger</name>
<affiliation wicri:level="1">
<inist:fA14 i1="13">
<s1>Max Planck Institute for Heart and Lung Research, Universities of Giessen and Marburg Lung Center</s1>
<s2>Giessen/Bad Nauheim</s2>
<s3>DEU</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
</affiliation>
</author>
<author>
<name sortKey="Keogh, Anne" sort="Keogh, Anne" uniqKey="Keogh A" first="Anne" last="Keogh">Anne Keogh</name>
<affiliation wicri:level="1">
<inist:fA14 i1="14">
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<s2>Sydney</s2>
<s3>AUS</s3>
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<country>Australie</country>
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<term>Pulmonary hypertension</term>
<term>Treatment</term>
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<term>Hypertension artérielle pulmonaire</term>
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<div type="abstract" xml:lang="en">The demands on a pulmonary arterial hypertension (PAH) treatment algorithm are multiple and in some ways conflicting. The treatment algorithm usually includes different types of recommendations with varying degrees of scientific evidence. In addition, the algorithm is required to be comprehensive but not too complex, informative yet simple and straightforward. The type of information in the treatment algorithm are heterogeneous including clinical, hemodynamic, medical, interventional, pharmacological and regulatory recommendations. Stakeholders (or users) including physicians from various specialties and with variable expertise in PAH, nurses, patients and patients' associations, healthcare providers, regulatory agencies and industry are often interested in the PAH treatment algorithm for different reasons. These are the considerable challenges faced when proposing appropriate updates to the current evidence-based treatment algorithm. The current treatment algorithm may be divided into 3 main areas: 1) general measures, supportive therapy, referral strategy, acute vasoreactivity testing and chronic treatment with calcium channel blockers; 2) initial therapy with approved PAH drugs; and 3) clinical response to the initial therapy, combination therapy, balloon atrial septostomy, and lung transplantation. All three sections will be revisited highlighting information newly available in the past 5 years and proposing updates where appropriate. The European Society of Cardiology grades of recommendation and levels of evidence will be adopted to rank the proposed treatments.</div>
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