Updated Treatment Algorithm of Pulmonary Arterial Hypertension
Identifieur interne : 005877 ( PascalFrancis/Curation ); précédent : 005876; suivant : 005878Updated Treatment Algorithm of Pulmonary Arterial Hypertension
Auteurs : Nazzareno Galie [Italie] ; Paul A. Corris [Royaume-Uni] ; Adaani Frost [États-Unis] ; Reda E. Girgis [États-Unis] ; John Granton [Canada] ; ZHI CHENG JING [République populaire de Chine] ; Walter Klepetko [Autriche] ; Michael D. Mcgoon [États-Unis] ; Vallerie V. Mclaughlin [États-Unis] ; Ioana R. Preston [États-Unis] ; Lewis J. Rubin [États-Unis] ; Julio Sandoval [Mexique] ; Werner Seeger [Allemagne] ; Anne Keogh [Australie]Source :
- Journal of the American College of Cardiology [ 0735-1097 ] ; 2013.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
The demands on a pulmonary arterial hypertension (PAH) treatment algorithm are multiple and in some ways conflicting. The treatment algorithm usually includes different types of recommendations with varying degrees of scientific evidence. In addition, the algorithm is required to be comprehensive but not too complex, informative yet simple and straightforward. The type of information in the treatment algorithm are heterogeneous including clinical, hemodynamic, medical, interventional, pharmacological and regulatory recommendations. Stakeholders (or users) including physicians from various specialties and with variable expertise in PAH, nurses, patients and patients' associations, healthcare providers, regulatory agencies and industry are often interested in the PAH treatment algorithm for different reasons. These are the considerable challenges faced when proposing appropriate updates to the current evidence-based treatment algorithm. The current treatment algorithm may be divided into 3 main areas: 1) general measures, supportive therapy, referral strategy, acute vasoreactivity testing and chronic treatment with calcium channel blockers; 2) initial therapy with approved PAH drugs; and 3) clinical response to the initial therapy, combination therapy, balloon atrial septostomy, and lung transplantation. All three sections will be revisited highlighting information newly available in the past 5 years and proposing updates where appropriate. The European Society of Cardiology grades of recommendation and levels of evidence will be adopted to rank the proposed treatments.
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<author><name sortKey="Seeger, Werner" sort="Seeger, Werner" uniqKey="Seeger W" first="Werner" last="Seeger">Werner Seeger</name>
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<author><name sortKey="Keogh, Anne" sort="Keogh, Anne" uniqKey="Keogh A" first="Anne" last="Keogh">Anne Keogh</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Updated Treatment Algorithm of Pulmonary Arterial Hypertension</title>
<author><name sortKey="Galie, Nazzareno" sort="Galie, Nazzareno" uniqKey="Galie N" first="Nazzareno" last="Galie">Nazzareno Galie</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Bologna University Hospital</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
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<author><name sortKey="Corris, Paul A" sort="Corris, Paul A" uniqKey="Corris P" first="Paul A." last="Corris">Paul A. Corris</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Cellular Medicine Newcastle University and The Newcastle Hospitals NHS Foundation Trust</s1>
<s2>Newcastle</s2>
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<sZ>2 aut.</sZ>
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<author><name sortKey="Frost, Adaani" sort="Frost, Adaani" uniqKey="Frost A" first="Adaani" last="Frost">Adaani Frost</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Baylor College of Medicine</s1>
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<author><name sortKey="Girgis, Reda E" sort="Girgis, Reda E" uniqKey="Girgis R" first="Reda E." last="Girgis">Reda E. Girgis</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Michigan State University, College of Human Medicine</s1>
<s2>Grand Rapids, Michigan</s2>
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<sZ>4 aut.</sZ>
</inist:fA14>
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</affiliation>
</author>
<author><name sortKey="Granton, John" sort="Granton, John" uniqKey="Granton J" first="John" last="Granton">John Granton</name>
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<s2>Toronto</s2>
<s3>CAN</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Canada</country>
</affiliation>
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<author><name sortKey="Zhi Cheng Jing" sort="Zhi Cheng Jing" uniqKey="Zhi Cheng Jing" last="Zhi Cheng Jing">ZHI CHENG JING</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Fu Wai Hospital & National Center for Cardiovascular Disease Peking Union Medical College and Chinese Academy of Medical Science</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>6 aut.</sZ>
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</affiliation>
</author>
<author><name sortKey="Klepetko, Walter" sort="Klepetko, Walter" uniqKey="Klepetko W" first="Walter" last="Klepetko">Walter Klepetko</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Thoracic Surgery, Medical University Vienna/Vienna General Hospital</s1>
<s2>Vienna</s2>
<s3>AUT</s3>
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</affiliation>
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<author><name sortKey="Mcgoon, Michael D" sort="Mcgoon, Michael D" uniqKey="Mcgoon M" first="Michael D." last="Mcgoon">Michael D. Mcgoon</name>
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<sZ>8 aut.</sZ>
</inist:fA14>
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</affiliation>
</author>
<author><name sortKey="Mclaughlin, Vallerie V" sort="Mclaughlin, Vallerie V" uniqKey="Mclaughlin V" first="Vallerie V." last="Mclaughlin">Vallerie V. Mclaughlin</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Cardiovascular Medicine, The University of Michigan</s1>
<s2>Ann Arbor, Michigan</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
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</author>
<author><name sortKey="Preston, Ioana R" sort="Preston, Ioana R" uniqKey="Preston I" first="Ioana R." last="Preston">Ioana R. Preston</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Pulmonary, Critical Care and Sleep Division, Tufts Medical Center, Tufts University School of Medicine</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Rubin, Lewis J" sort="Rubin, Lewis J" uniqKey="Rubin L" first="Lewis J." last="Rubin">Lewis J. Rubin</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Medical School, University of California, San Diego</s1>
<s2>La Jolla, California</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Sandoval, Julio" sort="Sandoval, Julio" uniqKey="Sandoval J" first="Julio" last="Sandoval">Julio Sandoval</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Clinical Research, National Institute of Cardiology of Mexico</s1>
<s2>Mexico City</s2>
<s3>MEX</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Mexique</country>
</affiliation>
</author>
<author><name sortKey="Seeger, Werner" sort="Seeger, Werner" uniqKey="Seeger W" first="Werner" last="Seeger">Werner Seeger</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Max Planck Institute for Heart and Lung Research, Universities of Giessen and Marburg Lung Center</s1>
<s2>Giessen/Bad Nauheim</s2>
<s3>DEU</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
</affiliation>
</author>
<author><name sortKey="Keogh, Anne" sort="Keogh, Anne" uniqKey="Keogh A" first="Anne" last="Keogh">Anne Keogh</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Heart Transplant Unit, St Vincent's Hospital</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Australie</country>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of the American College of Cardiology</title>
<title level="j" type="abbreviated">J. Am. Coll. Cardiol.</title>
<idno type="ISSN">0735-1097</idno>
<imprint><date when="2013">2013</date>
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</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Algorithm</term>
<term>Artery</term>
<term>Cardiology</term>
<term>Cardiovascular disease</term>
<term>Circulatory system</term>
<term>Decision tree</term>
<term>Pulmonary hypertension</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Hypertension artérielle pulmonaire</term>
<term>Pathologie de l'appareil circulatoire</term>
<term>Traitement</term>
<term>Algorithme</term>
<term>Arbre décision</term>
<term>Artère</term>
<term>Appareil circulatoire</term>
<term>Cardiologie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The demands on a pulmonary arterial hypertension (PAH) treatment algorithm are multiple and in some ways conflicting. The treatment algorithm usually includes different types of recommendations with varying degrees of scientific evidence. In addition, the algorithm is required to be comprehensive but not too complex, informative yet simple and straightforward. The type of information in the treatment algorithm are heterogeneous including clinical, hemodynamic, medical, interventional, pharmacological and regulatory recommendations. Stakeholders (or users) including physicians from various specialties and with variable expertise in PAH, nurses, patients and patients' associations, healthcare providers, regulatory agencies and industry are often interested in the PAH treatment algorithm for different reasons. These are the considerable challenges faced when proposing appropriate updates to the current evidence-based treatment algorithm. The current treatment algorithm may be divided into 3 main areas: 1) general measures, supportive therapy, referral strategy, acute vasoreactivity testing and chronic treatment with calcium channel blockers; 2) initial therapy with approved PAH drugs; and 3) clinical response to the initial therapy, combination therapy, balloon atrial septostomy, and lung transplantation. All three sections will be revisited highlighting information newly available in the past 5 years and proposing updates where appropriate. The European Society of Cardiology grades of recommendation and levels of evidence will be adopted to rank the proposed treatments.</div>
</front>
</TEI>
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<fA03 i2="1"><s0>J. Am. Coll. Cardiol.</s0>
</fA03>
<fA05><s2>62</s2>
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<fA06><s2>25</s2>
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<fA08 i1="01" i2="1" l="ENG"><s1>Updated Treatment Algorithm of Pulmonary Arterial Hypertension</s1>
</fA08>
<fA09 i1="01" i2="1" l="ENG"><s1>Updates in Pulmonary Hypertension: Proceedings of the 5th World Symposium on Pulmonary Hypertension</s1>
</fA09>
<fA11 i1="01" i2="1"><s1>GALIE (Nazzareno)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>CORRIS (Paul A.)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>FROST (Adaani)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>GIRGIS (Reda E.)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>GRANTON (John)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>ZHI CHENG JING</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>KLEPETKO (Walter)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>MCGOON (Michael D.)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>MCLAUGHLIN (Vallerie V.)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>PRESTON (Ioana R.)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>RUBIN (Lewis J.)</s1>
</fA11>
<fA11 i1="12" i2="1"><s1>SANDOVAL (Julio)</s1>
</fA11>
<fA11 i1="13" i2="1"><s1>SEEGER (Werner)</s1>
</fA11>
<fA11 i1="14" i2="1"><s1>KEOGH (Anne)</s1>
</fA11>
<fA12 i1="01" i2="1"><s1>GALIE (Nazzareno)</s1>
<s9>ed.</s9>
</fA12>
<fA12 i1="02" i2="1"><s1>SIMONNEAU (Gerald)</s1>
<s9>ed.</s9>
</fA12>
<fA14 i1="01"><s1>Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Bologna University Hospital</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Institute of Cellular Medicine Newcastle University and The Newcastle Hospitals NHS Foundation Trust</s1>
<s2>Newcastle</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Baylor College of Medicine</s1>
<s2>Houston, Texas</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Michigan State University, College of Human Medicine</s1>
<s2>Grand Rapids, Michigan</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Division of Respirology, University of Toronto</s1>
<s2>Toronto</s2>
<s3>CAN</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Fu Wai Hospital & National Center for Cardiovascular Disease Peking Union Medical College and Chinese Academy of Medical Science</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>Department of Thoracic Surgery, Medical University Vienna/Vienna General Hospital</s1>
<s2>Vienna</s2>
<s3>AUT</s3>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="08"><s1>Cardiovascular Diseases, Mayo Clinic</s1>
<s2>Rochester, Minnesota</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="09"><s1>Cardiovascular Medicine, The University of Michigan</s1>
<s2>Ann Arbor, Michigan</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="10"><s1>Pulmonary, Critical Care and Sleep Division, Tufts Medical Center, Tufts University School of Medicine</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="11"><s1>Medical School, University of California, San Diego</s1>
<s2>La Jolla, California</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
</fA14>
<fA14 i1="12"><s1>Clinical Research, National Institute of Cardiology of Mexico</s1>
<s2>Mexico City</s2>
<s3>MEX</s3>
<sZ>12 aut.</sZ>
</fA14>
<fA14 i1="13"><s1>Max Planck Institute for Heart and Lung Research, Universities of Giessen and Marburg Lung Center</s1>
<s2>Giessen/Bad Nauheim</s2>
<s3>DEU</s3>
<sZ>13 aut.</sZ>
</fA14>
<fA14 i1="14"><s1>Heart Transplant Unit, St Vincent's Hospital</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>14 aut.</sZ>
</fA14>
<fA15 i1="01"><s1>Department of Experimental, Diagnostic and Specialty Medicine-DIMES</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
</fA15>
<fA15 i1="02"><s1>Assistance Publique-Hôpitaux de Paris, Service de Pneumologie, Hôpital Universitaire de Bicêtre, Université Paris-Sud, Laboratoire d'excellence en Recherche sur le Médicament et Innovation Thérapeutique, INSERM, Unité 999</s1>
<s2>Le Kremlin-Bicêtre, Paris</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
</fA15>
<fA20><s2>D60-D72</s2>
</fA20>
<fA21><s1>2013</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>20098</s2>
<s5>354000500747320070</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2014 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>86 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>14-0036896</s0>
</fA47>
<fA60><s1>P</s1>
<s2>C</s2>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Journal of the American College of Cardiology</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>The demands on a pulmonary arterial hypertension (PAH) treatment algorithm are multiple and in some ways conflicting. The treatment algorithm usually includes different types of recommendations with varying degrees of scientific evidence. In addition, the algorithm is required to be comprehensive but not too complex, informative yet simple and straightforward. The type of information in the treatment algorithm are heterogeneous including clinical, hemodynamic, medical, interventional, pharmacological and regulatory recommendations. Stakeholders (or users) including physicians from various specialties and with variable expertise in PAH, nurses, patients and patients' associations, healthcare providers, regulatory agencies and industry are often interested in the PAH treatment algorithm for different reasons. These are the considerable challenges faced when proposing appropriate updates to the current evidence-based treatment algorithm. The current treatment algorithm may be divided into 3 main areas: 1) general measures, supportive therapy, referral strategy, acute vasoreactivity testing and chronic treatment with calcium channel blockers; 2) initial therapy with approved PAH drugs; and 3) clinical response to the initial therapy, combination therapy, balloon atrial septostomy, and lung transplantation. All three sections will be revisited highlighting information newly available in the past 5 years and proposing updates where appropriate. The European Society of Cardiology grades of recommendation and levels of evidence will be adopted to rank the proposed treatments.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B12A</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B11C</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Hypertension artérielle pulmonaire</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Pulmonary hypertension</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Hipertensión arterial pulmonar</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Pathologie de l'appareil circulatoire</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Cardiovascular disease</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Aparato circulatorio patología</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Traitement</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Treatment</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Tratamiento</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Algorithme</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Algorithm</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Algoritmo</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Arbre décision</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Decision tree</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Arbol decisión</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Artère</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Artery</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Arteria</s0>
<s5>12</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Appareil circulatoire</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Circulatory system</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Aparato circulatorio</s0>
<s5>13</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Cardiologie</s0>
<s5>14</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Cardiology</s0>
<s5>14</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Cardiología</s0>
<s5>14</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'appareil respiratoire</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Vaisseau sanguin</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Blood vessel</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Vaso sanguíneo</s0>
<s5>38</s5>
</fC07>
<fN21><s1>041</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
<pR><fA30 i1="01" i2="1" l="ENG"><s1>WSPH World Symposium on Pulmonary Hypertension</s1>
<s2>5</s2>
<s3>Nice FRA</s3>
<s4>2013-02-27</s4>
</fA30>
</pR>
</standard>
</inist>
</record>
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