AustralieFrV1, PascalFrancis, Curation, bibRecord, 005037

Angiotropism is an independent predictor of microscopic satellites in primary cutaneous melanoma

Identifieur interne : 005037 ( PascalFrancis/Curation ); précédent : 005036; suivant : 005038

Angiotropism is an independent predictor of microscopic satellites in primary cutaneous melanoma

Auteurs : James Wilmott [Australie] ; Lauren Haydu [Australie] ; Martine Bagot [France] ; YUXIAO ZHANG [Australie] ; Valerie Jakrot [Australie] ; Stanley Mccarthy [Australie] ; Claire Lugassy [France] ; John Thompson [Australie] ; Richard Scolyer [Australie] ; Raymond Barnhill [France]

Source :

Histopathology [ 0309-0167 ] ; 2012.

RBID : Pascal:12-0437421

Descripteurs français

Pascal (Inist)
- Microscopie, Prédiction, Facteur prédictif, Cancer de la peau, Satellite, Primaire, Mélanome malin, Anatomopathologie, Métastase.
Wicri :
- topic : Satellite.

English descriptors

KwdEn :
- Anatomic pathology, Malignant melanoma, Metastasis, Microscopy, Prediction, Predictive factor, Primary, Satellite, Skin cancer.

Abstract

Aims: To establish whether microscopic angiotropism of melanoma cells correlates with microscopic satellite (MS) formation in cutaneous melanomas and thus is likely to explain the development of MS. Materials and results: Patients with MS and controls without MS from 1996 to 2009 were evaluated for the presence or absence of angiotropism. MS was defined as a dermal/subcutaneous tumour nodule >0.05 mm, separated from the primary tumour by at least 0.3 mm. Forty four cases and controls were matched for tumour thickness, mitotic rate, ulceration, age, gender and primary site. Angiotropism (23 of 44, 52%) and absent regression (19 of 44, 43%) were significantly more frequent in melanomas with MS than in those without MS (controls) (12 of 44, 27%) (P = 0.017) and (32 of 44, 73%) (P = 0.005), respectively. Factors correlating with angiotropism included increased Clark level (P = 0.046), regression absence (P = 0.02) and MS (P = 0.017). On multivariable analysis, MS formation was predicted by angiotropism (P = 0.026), Clark level V (P = 0.01), absent regression (P = 0.009) and acral site (P = 0.02). Conclusions: Angiotropism predicts MS development. These data provide additional evidence for the importance of angiotropism as a means of melanoma metastasis.

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A03		`1`		`@0 Histopathology`
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A08	`01`	`1`	`ENG`	`@1 Angiotropism is an independent predictor of microscopic satellites in primary cutaneous melanoma`
A11	`01`	`1`		`@1 WILMOTT (James)`
A11	`02`	`1`		`@1 HAYDU (Lauren)`
A11	`03`	`1`		`@1 BAGOT (Martine)`
A11	`04`	`1`		`@1 YUXIAO ZHANG`
A11	`05`	`1`		`@1 JAKROT (Valerie)`
A11	`06`	`1`		`@1 MCCARTHY (Stanley)`
A11	`07`	`1`		`@1 LUGASSY (Claire)`
A11	`08`	`1`		`@1 THOMPSON (John)`
A11	`09`	`1`		`@1 SCOLYER (Richard)`
A11	`10`	`1`		`@1 BARNHILL (Raymond)`
A14	`01`			`@1 Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital @3 AUS @Z 1 aut. @Z 6 aut. @Z 9 aut.`
A14	`02`			`@1 Melanoma Institute Australia @3 AUS @Z 1 aut. @Z 2 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut. @Z 8 aut. @Z 9 aut.`
A14	`03`			`@1 Discipline ofPathology, Sydney Medical School, The University of Sydney @2 Sydney, NSW @3 AUS @Z 1 aut. @Z 6 aut. @Z 9 aut.`
A14	`04`			`@1 Discipline of Surgery, Sydney Medical School, The University of Sydney @2 Sydney, NSW @3 AUS @Z 2 aut. @Z 8 aut.`
A14	`05`			`@1 Department of Dermatology, Hôpital Saint-Louis @2 Paris @3 FRA @Z 3 aut. @Z 7 aut. @Z 10 aut.`
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A21				`@1 2012`
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C01	`01`		`ENG`	@0 Aims: To establish whether microscopic angiotropism of melanoma cells correlates with microscopic satellite (MS) formation in cutaneous melanomas and thus is likely to explain the development of MS. Materials and results: Patients with MS and controls without MS from 1996 to 2009 were evaluated for the presence or absence of angiotropism. MS was defined as a dermal/subcutaneous tumour nodule >0.05 mm, separated from the primary tumour by at least 0.3 mm. Forty four cases and controls were matched for tumour thickness, mitotic rate, ulceration, age, gender and primary site. Angiotropism (23 of 44, 52%) and absent regression (19 of 44, 43%) were significantly more frequent in melanomas with MS than in those without MS (controls) (12 of 44, 27%) (P = 0.017) and (32 of 44, 73%) (P = 0.005), respectively. Factors correlating with angiotropism included increased Clark level (P = 0.046), regression absence (P = 0.02) and MS (P = 0.017). On multivariable analysis, MS formation was predicted by angiotropism (P = 0.026), Clark level V (P = 0.01), absent regression (P = 0.009) and acral site (P = 0.02). Conclusions: Angiotropism predicts MS development. These data provide additional evidence for the importance of angiotropism as a means of melanoma metastasis.
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N44	`01`			`@1 OTO`
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Pascal:12-0437421

Le document en format XML

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<author><name sortKey="Barnhill, Raymond" sort="Barnhill, Raymond" uniqKey="Barnhill R" first="Raymond" last="Barnhill">Raymond Barnhill</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Angiotropism is an independent predictor of microscopic satellites in primary cutaneous melanoma</title>
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<author><name sortKey="Haydu, Lauren" sort="Haydu, Lauren" uniqKey="Haydu L" first="Lauren" last="Haydu">Lauren Haydu</name>
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<author><name sortKey="Bagot, Martine" sort="Bagot, Martine" uniqKey="Bagot M" first="Martine" last="Bagot">Martine Bagot</name>
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<author><name sortKey="Yuxiao Zhang" sort="Yuxiao Zhang" uniqKey="Yuxiao Zhang" last="Yuxiao Zhang">YUXIAO ZHANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Melanoma Institute Australia</s1>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
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</author>
<author><name sortKey="Jakrot, Valerie" sort="Jakrot, Valerie" uniqKey="Jakrot V" first="Valerie" last="Jakrot">Valerie Jakrot</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Melanoma Institute Australia</s1>
<s3>AUS</s3>
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</inist:fA14>
<country>Australie</country>
</affiliation>
</author>
<author><name sortKey="Mccarthy, Stanley" sort="Mccarthy, Stanley" uniqKey="Mccarthy S" first="Stanley" last="Mccarthy">Stanley Mccarthy</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital</s1>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
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<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Melanoma Institute Australia</s1>
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<country>Australie</country>
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<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Discipline ofPathology, Sydney Medical School, The University of Sydney</s1>
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<sZ>9 aut.</sZ>
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<country>Australie</country>
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<author><name sortKey="Lugassy, Claire" sort="Lugassy, Claire" uniqKey="Lugassy C" first="Claire" last="Lugassy">Claire Lugassy</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Dermatology, Hôpital Saint-Louis</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Thompson, John" sort="Thompson, John" uniqKey="Thompson J" first="John" last="Thompson">John Thompson</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Melanoma Institute Australia</s1>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Discipline of Surgery, Sydney Medical School, The University of Sydney</s1>
<s2>Sydney, NSW</s2>
<s3>AUS</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Australie</country>
</affiliation>
</author>
<author><name sortKey="Scolyer, Richard" sort="Scolyer, Richard" uniqKey="Scolyer R" first="Richard" last="Scolyer">Richard Scolyer</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital</s1>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Melanoma Institute Australia</s1>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Discipline ofPathology, Sydney Medical School, The University of Sydney</s1>
<s2>Sydney, NSW</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
</affiliation>
</author>
<author><name sortKey="Barnhill, Raymond" sort="Barnhill, Raymond" uniqKey="Barnhill R" first="Raymond" last="Barnhill">Raymond Barnhill</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Dermatology, Hôpital Saint-Louis</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Pathology, Hôpital Saint-Louis</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Histopathology</title>
<title level="j" type="abbreviated">Histopathology</title>
<idno type="ISSN">0309-0167</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Histopathology</title>
<title level="j" type="abbreviated">Histopathology</title>
<idno type="ISSN">0309-0167</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anatomic pathology</term>
<term>Malignant melanoma</term>
<term>Metastasis</term>
<term>Microscopy</term>
<term>Prediction</term>
<term>Predictive factor</term>
<term>Primary</term>
<term>Satellite</term>
<term>Skin cancer</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Microscopie</term>
<term>Prédiction</term>
<term>Facteur prédictif</term>
<term>Cancer de la peau</term>
<term>Satellite</term>
<term>Primaire</term>
<term>Mélanome malin</term>
<term>Anatomopathologie</term>
<term>Métastase</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Satellite</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Aims: To establish whether microscopic angiotropism of melanoma cells correlates with microscopic satellite (MS) formation in cutaneous melanomas and thus is likely to explain the development of MS. Materials and results: Patients with MS and controls without MS from 1996 to 2009 were evaluated for the presence or absence of angiotropism. MS was defined as a dermal/subcutaneous tumour nodule >0.05 mm, separated from the primary tumour by at least 0.3 mm. Forty four cases and controls were matched for tumour thickness, mitotic rate, ulceration, age, gender and primary site. Angiotropism (23 of 44, 52%) and absent regression (19 of 44, 43%) were significantly more frequent in melanomas with MS than in those without MS (controls) (12 of 44, 27%) (P = 0.017) and (32 of 44, 73%) (P = 0.005), respectively. Factors correlating with angiotropism included increased Clark level (P = 0.046), regression absence (P = 0.02) and MS (P = 0.017). On multivariable analysis, MS formation was predicted by angiotropism (P = 0.026), Clark level V (P = 0.01), absent regression (P = 0.009) and acral site (P = 0.02). Conclusions: Angiotropism predicts MS development. These data provide additional evidence for the importance of angiotropism as a means of melanoma metastasis.</div>
</front>
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<fA08 i1="01" i2="1" l="ENG"><s1>Angiotropism is an independent predictor of microscopic satellites in primary cutaneous melanoma</s1>
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<fA11 i1="01" i2="1"><s1>WILMOTT (James)</s1>
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<fA11 i1="02" i2="1"><s1>HAYDU (Lauren)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>BAGOT (Martine)</s1>
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<fA11 i1="04" i2="1"><s1>YUXIAO ZHANG</s1>
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<fA11 i1="07" i2="1"><s1>LUGASSY (Claire)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>THOMPSON (John)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>SCOLYER (Richard)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>BARNHILL (Raymond)</s1>
</fA11>
<fA14 i1="01"><s1>Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital</s1>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
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<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
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<fA14 i1="03"><s1>Discipline ofPathology, Sydney Medical School, The University of Sydney</s1>
<s2>Sydney, NSW</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Discipline of Surgery, Sydney Medical School, The University of Sydney</s1>
<s2>Sydney, NSW</s2>
<s3>AUS</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Department of Dermatology, Hôpital Saint-Louis</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Department of Pathology, Hôpital Saint-Louis</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>10 aut.</sZ>
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<fC01 i1="01" l="ENG"><s0>Aims: To establish whether microscopic angiotropism of melanoma cells correlates with microscopic satellite (MS) formation in cutaneous melanomas and thus is likely to explain the development of MS. Materials and results: Patients with MS and controls without MS from 1996 to 2009 were evaluated for the presence or absence of angiotropism. MS was defined as a dermal/subcutaneous tumour nodule >0.05 mm, separated from the primary tumour by at least 0.3 mm. Forty four cases and controls were matched for tumour thickness, mitotic rate, ulceration, age, gender and primary site. Angiotropism (23 of 44, 52%) and absent regression (19 of 44, 43%) were significantly more frequent in melanomas with MS than in those without MS (controls) (12 of 44, 27%) (P = 0.017) and (32 of 44, 73%) (P = 0.005), respectively. Factors correlating with angiotropism included increased Clark level (P = 0.046), regression absence (P = 0.02) and MS (P = 0.017). On multivariable analysis, MS formation was predicted by angiotropism (P = 0.026), Clark level V (P = 0.01), absent regression (P = 0.009) and acral site (P = 0.02). Conclusions: Angiotropism predicts MS development. These data provide additional evidence for the importance of angiotropism as a means of melanoma metastasis.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B24O</s0>
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<s5>04</s5>
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</fC03>
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Angiotropism is an independent predictor of microscopic satellites in primary cutaneous melanoma

Angiotropism is an independent predictor of microscopic satellites in primary cutaneous melanoma

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