AustralieFrV1, PascalFrancis, Curation, bibRecord, 004C97

Two lymph nodes draining the mouse liver are the preferential site of DC migration and T cell activation

Identifieur interne : 004C97 ( PascalFrancis/Curation ); précédent : 004C96; suivant : 004C98

Two lymph nodes draining the mouse liver are the preferential site of DC migration and T cell activation

Auteurs : Louise Barbier [Australie, France] ; SZUN SZUN TAY [Australie] ; Claire Mcguffog [Australie] ; James A. Triccas [Australie] ; Geoffrey W. Mccaughan [Australie] ; David G. Bowen [Australie] ; Patrick Bertolino [Australie]

Source :

Journal of hepatology [ 0168-8278 ] ; 2012.

RBID : Pascal:12-0310351

Descripteurs français

Pascal (Inist)
- Ganglion lymphatique, Animal, Souris, Foie, Migration, Lymphocyte T, Activation, Cellule dendritique, Gastroentérologie.
Wicri :
- topic : Migration.

English descriptors

KwdEn :
- Activation, Animal, Dendritic cell, Gastroenterology, Liver, Lymph node, Migration, Mouse, T-Lymphocyte.

Abstract

Background & Aims: Lymph nodes (LNs) play a critical role in host defence against pathogens. In rodents, lymphatic anatomy and drainage have been characterized for many different organs. Surprisingly, the LNs draining the mouse liver have not been clearly identified. This knowledge is of central importance to allow accurate characterization of immune responses to pathogens infecting the liver. It is also important for exploring immune responses in hepatic tumour models, and mechanisms underlying the relative tolerogenic properties of the liver. In this study, we used both anatomical and immunological approaches to identify the LN(s) draining the mouse liver. Methods: Evans Blue and purified dendritic cells were directly injected into the hepatic parenchyma. Results: Using Evans Blue, we identified three LNs adjacent to the liver that stained with the dye within the first 5 min, which we termed portal, coeliac, and first mesenteric LNs. We also provide evidence that dendritic cells (DCs) injected under the liver capsule preferentially migrate to the coeliac and portal nodes, leading to local activation of antigen-specific naive CD8 and CD4 T cells, suggesting this is a route of lymphatic drainage from the liver. Consistent with this result, cell-associated antigen injected under the liver capsule was also cross-presented to CD8 T cells in these nodes. Conclusions: These results suggest for the first time that the coeliac and portal nodes are the main LNs draining the liver, and that DCs exiting the liver can elicit primary T cell activation within these lymph nodes; first mesenteric nodes play a secondary role. We propose this nomenclature to be used as common designations for the observed structures.

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A03		`1`		`@0 J. hepatol.`
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A08	`01`	`1`	`ENG`	`@1 Two lymph nodes draining the mouse liver are the preferential site of DC migration and T cell activation`
A11	`01`	`1`		`@1 BARBIER (Louise)`
A11	`02`	`1`		`@1 SZUN SZUN TAY`
A11	`03`	`1`		`@1 MCGUFFOG (Claire)`
A11	`04`	`1`		`@1 TRICCAS (James A.)`
A11	`05`	`1`		`@1 MCCAUGHAN (Geoffrey W.)`
A11	`06`	`1`		`@1 BOWEN (David G.)`
A11	`07`	`1`		`@1 BERTOLINO (Patrick)`
A14	`01`			`@1 Centenary Institute and AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, University of Sydney @2 Sydney @3 AUS @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 5 aut. @Z 6 aut. @Z 7 aut.`
A14	`02`			`@1 General Surgery and Liver Transplantation, La Conception Hospital and Université de la Méditerranée @2 Marseille @3 FRA @Z 1 aut.`
A14	`03`			`@1 Department of Infectious Diseases and Immunology, University of Sydney @2 Sydney @3 AUS @Z 4 aut.`
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C01	`01`		`ENG`	@0 Background & Aims: Lymph nodes (LNs) play a critical role in host defence against pathogens. In rodents, lymphatic anatomy and drainage have been characterized for many different organs. Surprisingly, the LNs draining the mouse liver have not been clearly identified. This knowledge is of central importance to allow accurate characterization of immune responses to pathogens infecting the liver. It is also important for exploring immune responses in hepatic tumour models, and mechanisms underlying the relative tolerogenic properties of the liver. In this study, we used both anatomical and immunological approaches to identify the LN(s) draining the mouse liver. Methods: Evans Blue and purified dendritic cells were directly injected into the hepatic parenchyma. Results: Using Evans Blue, we identified three LNs adjacent to the liver that stained with the dye within the first 5 min, which we termed portal, coeliac, and first mesenteric LNs. We also provide evidence that dendritic cells (DCs) injected under the liver capsule preferentially migrate to the coeliac and portal nodes, leading to local activation of antigen-specific naive CD8 and CD4 T cells, suggesting this is a route of lymphatic drainage from the liver. Consistent with this result, cell-associated antigen injected under the liver capsule was also cross-presented to CD8 T cells in these nodes. Conclusions: These results suggest for the first time that the coeliac and portal nodes are the main LNs draining the liver, and that DCs exiting the liver can elicit primary T cell activation within these lymph nodes; first mesenteric nodes play a secondary role. We propose this nomenclature to be used as common designations for the observed structures.
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C03	`07`	`X`	`FRE`	`@0 Activation @5 16`
C03	`07`	`X`	`ENG`	`@0 Activation @5 16`
C03	`07`	`X`	`SPA`	`@0 Activación @5 16`
C03	`08`	`X`	`FRE`	`@0 Cellule dendritique @5 17`
C03	`08`	`X`	`ENG`	`@0 Dendritic cell @5 17`
C03	`08`	`X`	`SPA`	`@0 Célula dendrítica @5 17`
C03	`09`	`X`	`FRE`	`@0 Gastroentérologie @5 18`
C03	`09`	`X`	`ENG`	`@0 Gastroenterology @5 18`
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C07	`02`	`X`	`SPA`	`@0 Mammalia @2 NS`
C07	`03`	`X`	`FRE`	`@0 Vertebrata @2 NS`
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C07	`04`	`X`	`SPA`	`@0 Análisis inmunológico @5 37`
N21				`@1 240`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

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Pascal:12-0310351

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activation</term>
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<term>Liver</term>
<term>Lymph node</term>
<term>Migration</term>
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<term>Animal</term>
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<front><div type="abstract" xml:lang="en">Background & Aims: Lymph nodes (LNs) play a critical role in host defence against pathogens. In rodents, lymphatic anatomy and drainage have been characterized for many different organs. Surprisingly, the LNs draining the mouse liver have not been clearly identified. This knowledge is of central importance to allow accurate characterization of immune responses to pathogens infecting the liver. It is also important for exploring immune responses in hepatic tumour models, and mechanisms underlying the relative tolerogenic properties of the liver. In this study, we used both anatomical and immunological approaches to identify the LN(s) draining the mouse liver. Methods: Evans Blue and purified dendritic cells were directly injected into the hepatic parenchyma. Results: Using Evans Blue, we identified three LNs adjacent to the liver that stained with the dye within the first 5 min, which we termed portal, coeliac, and first mesenteric LNs. We also provide evidence that dendritic cells (DCs) injected under the liver capsule preferentially migrate to the coeliac and portal nodes, leading to local activation of antigen-specific naive CD8 and CD4 T cells, suggesting this is a route of lymphatic drainage from the liver. Consistent with this result, cell-associated antigen injected under the liver capsule was also cross-presented to CD8 T cells in these nodes. Conclusions: These results suggest for the first time that the coeliac and portal nodes are the main LNs draining the liver, and that DCs exiting the liver can elicit primary T cell activation within these lymph nodes; first mesenteric nodes play a secondary role. We propose this nomenclature to be used as common designations for the observed structures.</div>
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<fA11 i1="01" i2="1"><s1>BARBIER (Louise)</s1>
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<fA14 i1="01"><s1>Centenary Institute and AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, University of Sydney</s1>
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<sZ>5 aut.</sZ>
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<fA14 i1="02"><s1>General Surgery and Liver Transplantation, La Conception Hospital and Université de la Méditerranée</s1>
<s2>Marseille</s2>
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<fA14 i1="03"><s1>Department of Infectious Diseases and Immunology, University of Sydney</s1>
<s2>Sydney</s2>
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</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>20706</s2>
<s5>354000500869590170</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2012 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>29 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>12-0310351</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Journal of hepatology</s0>
</fA64>
<fA66 i1="01"><s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Background & Aims: Lymph nodes (LNs) play a critical role in host defence against pathogens. In rodents, lymphatic anatomy and drainage have been characterized for many different organs. Surprisingly, the LNs draining the mouse liver have not been clearly identified. This knowledge is of central importance to allow accurate characterization of immune responses to pathogens infecting the liver. It is also important for exploring immune responses in hepatic tumour models, and mechanisms underlying the relative tolerogenic properties of the liver. In this study, we used both anatomical and immunological approaches to identify the LN(s) draining the mouse liver. Methods: Evans Blue and purified dendritic cells were directly injected into the hepatic parenchyma. Results: Using Evans Blue, we identified three LNs adjacent to the liver that stained with the dye within the first 5 min, which we termed portal, coeliac, and first mesenteric LNs. We also provide evidence that dendritic cells (DCs) injected under the liver capsule preferentially migrate to the coeliac and portal nodes, leading to local activation of antigen-specific naive CD8 and CD4 T cells, suggesting this is a route of lymphatic drainage from the liver. Consistent with this result, cell-associated antigen injected under the liver capsule was also cross-presented to CD8 T cells in these nodes. Conclusions: These results suggest for the first time that the coeliac and portal nodes are the main LNs draining the liver, and that DCs exiting the liver can elicit primary T cell activation within these lymph nodes; first mesenteric nodes play a secondary role. We propose this nomenclature to be used as common designations for the observed structures.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B13</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Ganglion lymphatique</s0>
<s5>07</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Lymph node</s0>
<s5>07</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Ganglio linfático</s0>
<s5>07</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Animal</s0>
<s5>08</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Animal</s0>
<s5>08</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Animal</s0>
<s5>08</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Souris</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Mouse</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Ratón</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Foie</s0>
<s5>13</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Liver</s0>
<s5>13</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Hígado</s0>
<s5>13</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Migration</s0>
<s5>14</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Migration</s0>
<s5>14</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Migración</s0>
<s5>14</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Lymphocyte T</s0>
<s5>15</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>T-Lymphocyte</s0>
<s5>15</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Linfocito T</s0>
<s5>15</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Activation</s0>
<s5>16</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Activation</s0>
<s5>16</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Activación</s0>
<s5>16</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Cellule dendritique</s0>
<s5>17</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Dendritic cell</s0>
<s5>17</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Célula dendrítica</s0>
<s5>17</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Gastroentérologie</s0>
<s5>18</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Gastroenterology</s0>
<s5>18</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Gastroenterología</s0>
<s5>18</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Exploration immunologique</s0>
<s5>37</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Immunological investigation</s0>
<s5>37</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Análisis inmunológico</s0>
<s5>37</s5>
</fC07>
<fN21><s1>240</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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	Serveur d'exploration sur les relations entre la France et l'Australie
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Two lymph nodes draining the mouse liver are the preferential site of DC migration and T cell activation

Two lymph nodes draining the mouse liver are the preferential site of DC migration and T cell activation

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