Development and Preliminary Validation of a Magnetic Resonance Imaging Joint Space Narrowing Score for Use in Rheumatoid Arthritis: Potential Adjunct to the OMERACT RA MRI Scoring System
Identifieur interne : 004660 ( PascalFrancis/Curation ); précédent : 004659; suivant : 004661Development and Preliminary Validation of a Magnetic Resonance Imaging Joint Space Narrowing Score for Use in Rheumatoid Arthritis: Potential Adjunct to the OMERACT RA MRI Scoring System
Auteurs : Mikkel Stergaard [Danemark, Norvège, Israël, France, Australie, Pays-Bas, Allemagne, États-Unis, Royaume-Uni, Nouvelle-Zélande] ; Pernille B Yesen ; Iris Eshed ; Frédérique Gandjbakhch ; Siri Lillegraven ; Paul Bird ; Violaine Foltz ; Annelies Boonen ; Marissa Lassere ; Kay-Geert Hermann ; Allen Anandarajah ; Uffe M Ller D Hn ; Jane Freeston ; Charles G. Peterfy ; Harry K. Genant ; Espen A. Haavardsholm ; Fiona M. Mcqueen ; Philip G. ConaghanSource :
- Journal of rheumatology [ 0315-162X ] ; 2011.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Objective. To develop and validate a magnetic resonance imaging (MRI) method of assessment of joint space narrowing (JSN) in rheumatoid arthritis (RA). Methods. Phase A: JSN was scored 0-4 on MR images of 5 RA patients and 3 controls at 15 wrist sites and 2nd-5th metacarpophalangeal (MCP) joints by 8 readers (7 once, one twice), using a preliminary scoring system. Phase B: Image review, discussion, and consensus on JSN definition, and revised scoring system. Phase C: MR images of 15 RA patients and 4 controls were scored using revised system by 5 readers (4 once, one twice), and results compared with radiographs [Sharp-van der Heijde (SvdH) method]. Results. Phase A: Intraobserver agreement: intraclass correlation coefficient (ICC) = 0.99; smallest detectable difference (SDD, for mean of readings) = 2.8 JSN units (4.9% of observed maximal score). Interobserver agreement: ICC = 0.93; SDD = 6.4 JSN units (9.9%). Phase B: Agreement was reached on JSN definition (reduced joint space width compared to normal, as assessed in a slice perpendicular to the joint surface), and revised scoring system (0-4 at 17 wrist sites and 2nd-5th MCP; 0: none; 1: 1-33%; 2: 34-66%; 3: 67-99%; 4: ankylosis). Phase C: Intraobserver agreement: ICC = 0.90; SDD = 6.8 JSN units (11.0%). Interobserver agreement: ICC = 0.92 and SDD = 6.2 JSN units (8.7%). The correlation (ICC) with the SvdH radiographic JSN score of the wrist/hand was 0.77. Simplified approaches evaluating fewer joint spaces demonstrated similar reliability and correlation with radiographic scores. Conclusion. An MRI scoring system of JSN in RA wrist and MCP joints was developed and showed construct validity and good intra- and interreader agreements. The system may, after further validation in longitudinal data sets, be useful as an outcome measure in RA.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Development and Preliminary Validation of a Magnetic Resonance Imaging Joint Space Narrowing Score for Use in Rheumatoid Arthritis: Potential Adjunct to the OMERACT RA MRI Scoring System</title><author><name sortKey=" Stergaard, Mikkel" sort=" Stergaard, Mikkel" uniqKey=" Stergaard M" first="Mikkel" last=" Stergaard">Mikkel Stergaard</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Rheumatology, Copenhagen University Hospital at Glostrup</s1><s2>Copenhagen</s2><s3>DNK</s3></inist:fA14><country>Danemark</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Rheumatology, Diakonhjemmet Hospital</s1><s2>Oslo</s2><s3>NOR</s3></inist:fA14><country>Norvège</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Sheba Medical Center, Tel Aviv University</s1><s2>Tel Aviv</s2><s3>ISR</s3></inist:fA14><country>Israël</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Rheumatology, Pitié Salpetriere Hospital, APHP, Université Paris 6-UPMC</s1><s2>Paris</s2><s3>FRA</s3></inist:fA14><country>France</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Division of Medicine, University of NSW</s1><s2>Sydney</s2><s3>AUS</s3></inist:fA14><country>Australie</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Maastricht University Medical Center</s1><s2>Maastricht</s2><s3>NLD</s3></inist:fA14><country>Pays-Bas</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Radiology, Charité University Hospital</s1><s2>Berlin</s2><s3>DEU</s3></inist:fA14><country>Allemagne</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Allergy, Immunology and Rheumatology, University of Rochester Medical Center</s1><s2>Rochester, NY</s2><s3>USA</s3></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Section of Musculoskeletal Disease, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit</s1><s3>GBR</s3></inist:fA14><country>Royaume-Uni</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Spire Sciences LLC; University of California San Francisco</s1><s2>San Francisco, CA</s2><s3>USA</s3></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Synarc, Inc.</s1><s2>San Francisco</s2><s3>USA</s3></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Molecular Medicine and Pathology, Faculty of Medicine and Health Sciences, University of Auckland</s1><s2>Auckland</s2><s3>NZL</s3></inist:fA14><country>Nouvelle-Zélande</country></affiliation></author><author><name sortKey="B Yesen, Pernille" sort="B Yesen, Pernille" uniqKey="B Yesen P" first="Pernille" last="B Yesen">Pernille B Yesen</name></author><author><name sortKey="Eshed, Iris" sort="Eshed, Iris" uniqKey="Eshed I" first="Iris" last="Eshed">Iris Eshed</name></author><author><name sortKey="Gandjbakhch, Frederique" sort="Gandjbakhch, Frederique" uniqKey="Gandjbakhch F" first="Frédérique" last="Gandjbakhch">Frédérique Gandjbakhch</name></author><author><name sortKey="Lillegraven, Siri" sort="Lillegraven, Siri" uniqKey="Lillegraven S" first="Siri" last="Lillegraven">Siri Lillegraven</name></author><author><name sortKey="Bird, Paul" sort="Bird, Paul" uniqKey="Bird P" first="Paul" last="Bird">Paul Bird</name></author><author><name sortKey="Foltz, Violaine" sort="Foltz, Violaine" uniqKey="Foltz V" first="Violaine" last="Foltz">Violaine Foltz</name></author><author><name sortKey="Boonen, Annelies" sort="Boonen, Annelies" uniqKey="Boonen A" first="Annelies" last="Boonen">Annelies Boonen</name></author><author><name sortKey="Lassere, Marissa" sort="Lassere, Marissa" uniqKey="Lassere M" first="Marissa" last="Lassere">Marissa Lassere</name></author><author><name sortKey="Hermann, Kay Geert" sort="Hermann, Kay Geert" uniqKey="Hermann K" first="Kay-Geert" last="Hermann">Kay-Geert Hermann</name></author><author><name sortKey="Anandarajah, Allen" sort="Anandarajah, Allen" uniqKey="Anandarajah A" first="Allen" last="Anandarajah">Allen Anandarajah</name></author><author><name sortKey="M Ller D Hn, Uffe" sort="M Ller D Hn, Uffe" uniqKey="M Ller D Hn U" first="Uffe" last="M Ller D Hn">Uffe M Ller D Hn</name></author><author><name sortKey="Freeston, Jane" sort="Freeston, Jane" uniqKey="Freeston J" first="Jane" last="Freeston">Jane Freeston</name></author><author><name sortKey="Peterfy, Charles G" sort="Peterfy, Charles G" uniqKey="Peterfy C" first="Charles G." last="Peterfy">Charles G. Peterfy</name></author><author><name sortKey="Genant, Harry K" sort="Genant, Harry K" uniqKey="Genant H" first="Harry K." last="Genant">Harry K. Genant</name></author><author><name sortKey="Haavardsholm, Espen A" sort="Haavardsholm, Espen A" uniqKey="Haavardsholm E" first="Espen A." last="Haavardsholm">Espen A. Haavardsholm</name></author><author><name sortKey="Mcqueen, Fiona M" sort="Mcqueen, Fiona M" uniqKey="Mcqueen F" first="Fiona M." last="Mcqueen">Fiona M. Mcqueen</name></author><author><name sortKey="Conaghan, Philip G" sort="Conaghan, Philip G" uniqKey="Conaghan P" first="Philip G." last="Conaghan">Philip G. Conaghan</name></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">11-0453036</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 11-0453036 INIST</idno><idno type="RBID">Pascal:11-0453036</idno><idno type="wicri:Area/PascalFrancis/Corpus">001896</idno><idno type="wicri:Area/PascalFrancis/Curation">004660</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Development and Preliminary Validation of a Magnetic Resonance Imaging Joint Space Narrowing Score for Use in Rheumatoid Arthritis: Potential Adjunct to the OMERACT RA MRI Scoring System</title><author><name sortKey=" Stergaard, Mikkel" sort=" Stergaard, Mikkel" uniqKey=" Stergaard M" first="Mikkel" last=" Stergaard">Mikkel Stergaard</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Rheumatology, Copenhagen University Hospital at Glostrup</s1><s2>Copenhagen</s2><s3>DNK</s3></inist:fA14><country>Danemark</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Rheumatology, Diakonhjemmet Hospital</s1><s2>Oslo</s2><s3>NOR</s3></inist:fA14><country>Norvège</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Sheba Medical Center, Tel Aviv University</s1><s2>Tel Aviv</s2><s3>ISR</s3></inist:fA14><country>Israël</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Rheumatology, Pitié Salpetriere Hospital, APHP, Université Paris 6-UPMC</s1><s2>Paris</s2><s3>FRA</s3></inist:fA14><country>France</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Division of Medicine, University of NSW</s1><s2>Sydney</s2><s3>AUS</s3></inist:fA14><country>Australie</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Maastricht University Medical Center</s1><s2>Maastricht</s2><s3>NLD</s3></inist:fA14><country>Pays-Bas</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Radiology, Charité University Hospital</s1><s2>Berlin</s2><s3>DEU</s3></inist:fA14><country>Allemagne</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Allergy, Immunology and Rheumatology, University of Rochester Medical Center</s1><s2>Rochester, NY</s2><s3>USA</s3></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Section of Musculoskeletal Disease, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit</s1><s3>GBR</s3></inist:fA14><country>Royaume-Uni</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Spire Sciences LLC; University of California San Francisco</s1><s2>San Francisco, CA</s2><s3>USA</s3></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Synarc, Inc.</s1><s2>San Francisco</s2><s3>USA</s3></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Molecular Medicine and Pathology, Faculty of Medicine and Health Sciences, University of Auckland</s1><s2>Auckland</s2><s3>NZL</s3></inist:fA14><country>Nouvelle-Zélande</country></affiliation></author><author><name sortKey="B Yesen, Pernille" sort="B Yesen, Pernille" uniqKey="B Yesen P" first="Pernille" last="B Yesen">Pernille B Yesen</name></author><author><name sortKey="Eshed, Iris" sort="Eshed, Iris" uniqKey="Eshed I" first="Iris" last="Eshed">Iris Eshed</name></author><author><name sortKey="Gandjbakhch, Frederique" sort="Gandjbakhch, Frederique" uniqKey="Gandjbakhch F" first="Frédérique" last="Gandjbakhch">Frédérique Gandjbakhch</name></author><author><name sortKey="Lillegraven, Siri" sort="Lillegraven, Siri" uniqKey="Lillegraven S" first="Siri" last="Lillegraven">Siri Lillegraven</name></author><author><name sortKey="Bird, Paul" sort="Bird, Paul" uniqKey="Bird P" first="Paul" last="Bird">Paul Bird</name></author><author><name sortKey="Foltz, Violaine" sort="Foltz, Violaine" uniqKey="Foltz V" first="Violaine" last="Foltz">Violaine Foltz</name></author><author><name sortKey="Boonen, Annelies" sort="Boonen, Annelies" uniqKey="Boonen A" first="Annelies" last="Boonen">Annelies Boonen</name></author><author><name sortKey="Lassere, Marissa" sort="Lassere, Marissa" uniqKey="Lassere M" first="Marissa" last="Lassere">Marissa Lassere</name></author><author><name sortKey="Hermann, Kay Geert" sort="Hermann, Kay Geert" uniqKey="Hermann K" first="Kay-Geert" last="Hermann">Kay-Geert Hermann</name></author><author><name sortKey="Anandarajah, Allen" sort="Anandarajah, Allen" uniqKey="Anandarajah A" first="Allen" last="Anandarajah">Allen Anandarajah</name></author><author><name sortKey="M Ller D Hn, Uffe" sort="M Ller D Hn, Uffe" uniqKey="M Ller D Hn U" first="Uffe" last="M Ller D Hn">Uffe M Ller D Hn</name></author><author><name sortKey="Freeston, Jane" sort="Freeston, Jane" uniqKey="Freeston J" first="Jane" last="Freeston">Jane Freeston</name></author><author><name sortKey="Peterfy, Charles G" sort="Peterfy, Charles G" uniqKey="Peterfy C" first="Charles G." last="Peterfy">Charles G. Peterfy</name></author><author><name sortKey="Genant, Harry K" sort="Genant, Harry K" uniqKey="Genant H" first="Harry K." last="Genant">Harry K. Genant</name></author><author><name sortKey="Haavardsholm, Espen A" sort="Haavardsholm, Espen A" uniqKey="Haavardsholm E" first="Espen A." last="Haavardsholm">Espen A. Haavardsholm</name></author><author><name sortKey="Mcqueen, Fiona M" sort="Mcqueen, Fiona M" uniqKey="Mcqueen F" first="Fiona M." last="Mcqueen">Fiona M. Mcqueen</name></author><author><name sortKey="Conaghan, Philip G" sort="Conaghan, Philip G" uniqKey="Conaghan P" first="Philip G." last="Conaghan">Philip G. Conaghan</name></author></analytic><series><title level="j" type="main">Journal of rheumatology</title><title level="j" type="abbreviated">J. rheumatol.</title><idno type="ISSN">0315-162X</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of rheumatology</title><title level="j" type="abbreviated">J. rheumatol.</title><idno type="ISSN">0315-162X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cartilage</term><term>Chronic</term><term>Evaluation scale</term><term>Joint space</term><term>Nuclear magnetic resonance imaging</term><term>Prognosis</term><term>Radiography</term><term>Rheumatoid arthritis</term><term>Rheumatology</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Polyarthrite rhumatoïde</term><term>Radiographie</term><term>Imagerie RMN</term><term>Echelle d'évaluation</term><term>Cartilage</term><term>Pronostic</term><term>Rhumatologie</term><term>Chronique</term><term>Interligne articulaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective. To develop and validate a magnetic resonance imaging (MRI) method of assessment of joint space narrowing (JSN) in rheumatoid arthritis (RA). Methods. Phase A: JSN was scored 0-4 on MR images of 5 RA patients and 3 controls at 15 wrist sites and 2nd-5th metacarpophalangeal (MCP) joints by 8 readers (7 once, one twice), using a preliminary scoring system. Phase B: Image review, discussion, and consensus on JSN definition, and revised scoring system. Phase C: MR images of 15 RA patients and 4 controls were scored using revised system by 5 readers (4 once, one twice), and results compared with radiographs [Sharp-van der Heijde (SvdH) method]. Results. Phase A: Intraobserver agreement: intraclass correlation coefficient (ICC) = 0.99; smallest detectable difference (SDD, for mean of readings) = 2.8 JSN units (4.9% of observed maximal score). Interobserver agreement: ICC = 0.93; SDD = 6.4 JSN units (9.9%). Phase B: Agreement was reached on JSN definition (reduced joint space width compared to normal, as assessed in a slice perpendicular to the joint surface), and revised scoring system (0-4 at 17 wrist sites and 2nd-5th MCP; 0: none; 1: 1-33%; 2: 34-66%; 3: 67-99%; 4: ankylosis). Phase C: Intraobserver agreement: ICC = 0.90; SDD = 6.8 JSN units (11.0%). Interobserver agreement: ICC = 0.92 and SDD = 6.2 JSN units (8.7%). The correlation (ICC) with the SvdH radiographic JSN score of the wrist/hand was 0.77. Simplified approaches evaluating fewer joint spaces demonstrated similar reliability and correlation with radiographic scores. Conclusion. An MRI scoring system of JSN in RA wrist and MCP joints was developed and showed construct validity and good intra- and interreader agreements. The system may, after further validation in longitudinal data sets, be useful as an outcome measure in RA.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0315-162X</s0></fA01><fA02 i1="01"><s0>JRHUA9</s0></fA02><fA03 i2="1"><s0>J. rheumatol.</s0></fA03><fA05><s2>38</s2></fA05><fA06><s2>9</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Development and Preliminary Validation of a Magnetic Resonance Imaging Joint Space Narrowing Score for Use in Rheumatoid Arthritis: Potential Adjunct to the OMERACT RA MRI Scoring System</s1></fA08><fA11 i1="01" i2="1"><s1>ØSTERGAARD (Mikkel)</s1></fA11><fA11 i1="02" i2="1"><s1>BØYESEN (Pernille)</s1></fA11><fA11 i1="03" i2="1"><s1>ESHED (Iris)</s1></fA11><fA11 i1="04" i2="1"><s1>GANDJBAKHCH (Frédérique)</s1></fA11><fA11 i1="05" i2="1"><s1>LILLEGRAVEN (Siri)</s1></fA11><fA11 i1="06" i2="1"><s1>BIRD (Paul)</s1></fA11><fA11 i1="07" i2="1"><s1>FOLTZ (Violaine)</s1></fA11><fA11 i1="08" i2="1"><s1>BOONEN (Annelies)</s1></fA11><fA11 i1="09" i2="1"><s1>LASSERE (Marissa)</s1></fA11><fA11 i1="10" i2="1"><s1>HERMANN (Kay-Geert)</s1></fA11><fA11 i1="11" i2="1"><s1>ANANDARAJAH (Allen)</s1></fA11><fA11 i1="12" i2="1"><s1>MØLLER DØHN (Uffe)</s1></fA11><fA11 i1="13" i2="1"><s1>FREESTON (Jane)</s1></fA11><fA11 i1="14" i2="1"><s1>PETERFY (Charles G.)</s1></fA11><fA11 i1="15" i2="1"><s1>GENANT (Harry K.)</s1></fA11><fA11 i1="16" i2="1"><s1>HAAVARDSHOLM (Espen A.)</s1></fA11><fA11 i1="17" i2="1"><s1>MCQUEEN (Fiona M.)</s1></fA11><fA11 i1="18" i2="1"><s1>CONAGHAN (Philip G.)</s1></fA11><fA14 i1="01"><s1>Department of Rheumatology, Copenhagen University Hospital at Glostrup</s1><s2>Copenhagen</s2><s3>DNK</s3></fA14><fA14 i1="02"><s1>Department of Rheumatology, Diakonhjemmet Hospital</s1><s2>Oslo</s2><s3>NOR</s3></fA14><fA14 i1="03"><s1>Sheba Medical Center, Tel Aviv University</s1><s2>Tel Aviv</s2><s3>ISR</s3></fA14><fA14 i1="04"><s1>Department of Rheumatology, Pitié Salpetriere Hospital, APHP, Université Paris 6-UPMC</s1><s2>Paris</s2><s3>FRA</s3></fA14><fA14 i1="05"><s1>Division of Medicine, University of NSW</s1><s2>Sydney</s2><s3>AUS</s3></fA14><fA14 i1="06"><s1>Maastricht University Medical Center</s1><s2>Maastricht</s2><s3>NLD</s3></fA14><fA14 i1="07"><s1>Department of Radiology, Charité University Hospital</s1><s2>Berlin</s2><s3>DEU</s3></fA14><fA14 i1="08"><s1>Department of Allergy, Immunology and Rheumatology, University of Rochester Medical Center</s1><s2>Rochester, NY</s2><s3>USA</s3></fA14><fA14 i1="09"><s1>Section of Musculoskeletal Disease, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit</s1><s3>GBR</s3></fA14><fA14 i1="10"><s1>Spire Sciences LLC; University of California San Francisco</s1><s2>San Francisco, CA</s2><s3>USA</s3></fA14><fA14 i1="11"><s1>Synarc, Inc.</s1><s2>San Francisco</s2><s3>USA</s3></fA14><fA14 i1="12"><s1>Department of Molecular Medicine and Pathology, Faculty of Medicine and Health Sciences, University of Auckland</s1><s2>Auckland</s2><s3>NZL</s3></fA14><fA20><s1>2045-2050</s1></fA20><fA21><s1>2011</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>16024</s2><s5>354000507803790400</s5></fA43><fA44><s0>0000</s0><s1>© 2011 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>7 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>11-0453036</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Journal of rheumatology</s0></fA64><fA66 i1="01"><s0>CAN</s0></fA66><fC01 i1="01" l="ENG"><s0>Objective. To develop and validate a magnetic resonance imaging (MRI) method of assessment of joint space narrowing (JSN) in rheumatoid arthritis (RA). Methods. Phase A: JSN was scored 0-4 on MR images of 5 RA patients and 3 controls at 15 wrist sites and 2nd-5th metacarpophalangeal (MCP) joints by 8 readers (7 once, one twice), using a preliminary scoring system. Phase B: Image review, discussion, and consensus on JSN definition, and revised scoring system. Phase C: MR images of 15 RA patients and 4 controls were scored using revised system by 5 readers (4 once, one twice), and results compared with radiographs [Sharp-van der Heijde (SvdH) method]. Results. Phase A: Intraobserver agreement: intraclass correlation coefficient (ICC) = 0.99; smallest detectable difference (SDD, for mean of readings) = 2.8 JSN units (4.9% of observed maximal score). Interobserver agreement: ICC = 0.93; SDD = 6.4 JSN units (9.9%). Phase B: Agreement was reached on JSN definition (reduced joint space width compared to normal, as assessed in a slice perpendicular to the joint surface), and revised scoring system (0-4 at 17 wrist sites and 2nd-5th MCP; 0: none; 1: 1-33%; 2: 34-66%; 3: 67-99%; 4: ankylosis). Phase C: Intraobserver agreement: ICC = 0.90; SDD = 6.8 JSN units (11.0%). Interobserver agreement: ICC = 0.92 and SDD = 6.2 JSN units (8.7%). The correlation (ICC) with the SvdH radiographic JSN score of the wrist/hand was 0.77. Simplified approaches evaluating fewer joint spaces demonstrated similar reliability and correlation with radiographic scores. Conclusion. An MRI scoring system of JSN in RA wrist and MCP joints was developed and showed construct validity and good intra- and interreader agreements. The system may, after further validation in longitudinal data sets, be useful as an outcome measure in RA.</s0></fC01><fC02 i1="01" i2="X"><s0>002B15D</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Polyarthrite rhumatoïde</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Rheumatoid arthritis</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Poliartritis reumatoidea</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Radiographie</s0><s5>04</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Radiography</s0><s5>04</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Radiografía</s0><s5>04</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Imagerie RMN</s0><s5>07</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Nuclear magnetic resonance imaging</s0><s5>07</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Imaginería RMN</s0><s5>07</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Echelle d'évaluation</s0><s5>08</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Evaluation scale</s0><s5>08</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Escala evaluación</s0><s5>08</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Cartilage</s0><s5>09</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Cartilage</s0><s5>09</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Cartílago</s0><s5>09</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Pronostic</s0><s5>13</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Prognosis</s0><s5>13</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Pronóstico</s0><s5>13</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Rhumatologie</s0><s5>14</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Rheumatology</s0><s5>14</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Reumatología</s0><s5>14</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Chronique</s0><s5>30</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Chronic</s0><s5>30</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Crónico</s0><s5>30</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Interligne articulaire</s0><s4>CD</s4><s5>96</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Joint space</s0><s4>CD</s4><s5>96</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Imagerie médicale</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Medical imagery</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Imaginería médica</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Maladie autoimmune</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Autoimmune disease</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Enfermedad autoinmune</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Rhumatisme inflammatoire</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Inflammatory joint disease</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Reumatismo inflamatorio</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du système ostéoarticulaire</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Diseases of the osteoarticular system</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Sistema osteoarticular patología</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Exploration</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Exploration</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Exploración</s0><s5>41</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Radiodiagnostic</s0><s5>42</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Radiodiagnosis</s0><s5>42</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Radiodiagnóstico</s0><s5>42</s5></fC07><fC07 i1="07" i2="X" l="FRE"><s0>Immunopathologie</s0><s5>43</s5></fC07><fC07 i1="07" i2="X" l="ENG"><s0>Immunopathology</s0><s5>43</s5></fC07><fC07 i1="07" i2="X" l="SPA"><s0>Inmunopatología</s0><s5>43</s5></fC07><fN21><s1>311</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist></record>Pour manipuler ce document sous Unix (Dilib)
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