Chromosomal rearrangements maintain a polymorphic supergene controlling butterfly mimicry
Identifieur interne : 004586 ( PascalFrancis/Curation ); précédent : 004585; suivant : 004587Chromosomal rearrangements maintain a polymorphic supergene controlling butterfly mimicry
Auteurs : Mathieu Joron [France, Royaume-Uni, Pays-Bas] ; Lise Frezal [France] ; Robert T. Jones [Royaume-Uni] ; Nicola L. Chamberlain [Royaume-Uni] ; Siu F. Lee [Australie] ; Christoph R. Haag [Suisse] ; Annabel Whibley [France] ; Michel Becuwe [Royaume-Uni] ; Simon W. Baxter [Royaume-Uni] ; Laura Ferguson [Royaume-Uni] ; Paul A. Wilkinson [Royaume-Uni] ; Camilo Salazar [Panama] ; Claire Davidson [Royaume-Uni] ; Richard Clark [Royaume-Uni] ; Michael A. Quail [Royaume-Uni] ; Helen Beasley [Royaume-Uni] ; Rebecca Glithero [Royaume-Uni] ; Christine Lloyd [Royaume-Uni] ; Sarah Sims [Royaume-Uni] ; Matthew C. Jones [Royaume-Uni] ; Jane Rogers [Royaume-Uni] ; Chris D. Jiggins [Royaume-Uni] ; Richard H. Ffrench-Constant [Royaume-Uni]Source :
- Nature : (London) [ 0028-0836 ] ; 2011.
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Abstract
Supergenes are tight clusters of loci that facilitate the co-segregation of adaptive variation, providing integrated control of complex adaptive phenotypes'. Polymorphic supergenes, in which specific combinations of traits are maintained within a single population, were first described for 'pin' and 'thrum' floral types in Primula1 and Fagopyrum2, but classic examples are also found in insect mimicry3-5 and snail morphology6. Understanding the evolutionary mechanisms that generate these co-adapted gene sets, as well as the mode of limiting the production of unfit recombinant forms, remains a substantial challenge7-10. Here we show that individual wing-pattern morphs in the polymorphic mimetic butterfly Heliconius numata are associated with different genomic rearrangements at the supergene locus P. These rearrangements tighten the genetic linkage between at least two colour-pattern loci that are known to recombine in closely related species9-11, with complete suppression of recombination being observed in experimental crosses across a 400-kilobase interval containing at least 18 genes. In natural populations, notable patterns of linkage disequilibrium (LD) are observed across the entire P region. The resulting divergent haplotype clades and inversion breakpoints are found in complete association with wing-pattern morphs. Our results indicate that allelic combinations at known wing-patterning loci have become locked together in a polymorphic rearrangement at the P locus, forming a supergene that acts as a simple switch between complex adaptive phenotypes found in sympatry. These findings highlight how genomic rearrangements can have a central role in the coexistence of adaptive phenotypes involving several genes acting in concert, by locally limiting recombination and gene flow.
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Jones</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>The Wellcome Trust Sanger Institute</s1><s2>Hinxton, Cambridge CB10 1HH</s2><s3>GBR</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Rogers, Jane" sort="Rogers, Jane" uniqKey="Rogers J" first="Jane" last="Rogers">Jane Rogers</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>The Wellcome Trust Sanger Institute</s1><s2>Hinxton, Cambridge CB10 1HH</s2><s3>GBR</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Jiggins, Chris D" sort="Jiggins, Chris D" uniqKey="Jiggins C" first="Chris D." last="Jiggins">Chris D. Jiggins</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Zoology, University of Cambridge, Downing Street</s1><s2>Cambridge CB2 3EJ</s2><s3>GBR</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Ffrench Constant, Richard H" sort="Ffrench Constant, Richard H" uniqKey="Ffrench Constant R" first="Richard H." last="Ffrench-Constant">Richard H. Ffrench-Constant</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Centre for Ecology and Conservation, School of Biosciences, University of Exeter, Cornwall Campus, Penryn</s1><s2>Cornwall TR10 9EZ</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">11-0403590</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 11-0403590 INIST</idno><idno type="RBID">Pascal:11-0403590</idno><idno type="wicri:Area/PascalFrancis/Corpus">001969</idno><idno type="wicri:Area/PascalFrancis/Curation">004586</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Chromosomal rearrangements maintain a polymorphic supergene controlling butterfly mimicry</title><author><name sortKey="Joron, Mathieu" sort="Joron, Mathieu" uniqKey="Joron M" first="Mathieu" last="Joron">Mathieu Joron</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>CNRS UMR 7205, Museum National d'Histoire Naturelle, CP50, 45 Rue Buffon</s1><s2>75005 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, King's Buildings, West Mains Road</s1><s2>Edinburgh EH9 3JT</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Biology, Leiden University, Postbus 9505</s1><s2>2300 RA Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ></inist:fA14><country>Pays-Bas</country></affiliation></author><author><name sortKey="Frezal, Lise" sort="Frezal, Lise" uniqKey="Frezal L" first="Lise" last="Frezal">Lise Frezal</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>CNRS UMR 7205, Museum National d'Histoire Naturelle, CP50, 45 Rue Buffon</s1><s2>75005 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Jones, Robert T" sort="Jones, Robert T" uniqKey="Jones R" first="Robert T." last="Jones">Robert T. Jones</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Centre for Ecology and Conservation, School of Biosciences, University of Exeter, Cornwall Campus, Penryn</s1><s2>Cornwall TR10 9EZ</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Chamberlain, Nicola L" sort="Chamberlain, Nicola L" uniqKey="Chamberlain N" first="Nicola L." last="Chamberlain">Nicola L. Chamberlain</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Centre for Ecology and Conservation, School of Biosciences, University of Exeter, Cornwall Campus, Penryn</s1><s2>Cornwall TR10 9EZ</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Lee, Siu F" sort="Lee, Siu F" uniqKey="Lee S" first="Siu F." last="Lee">Siu F. Lee</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Genetics, Bio21 Institute, University of Melbourne, 30 Flemington Road</s1><s2>Parkville, 3010 Victoria</s2><s3>AUS</s3><sZ>5 aut.</sZ></inist:fA14><country>Australie</country></affiliation></author><author><name sortKey="Haag, Christoph R" sort="Haag, Christoph R" uniqKey="Haag C" first="Christoph R." last="Haag">Christoph R. Haag</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Biology, Ecology and Evolution, University of Fribourg, Chemin du Musee 10</s1><s2>1700 Fribourg</s2><s3>CHE</s3><sZ>6 aut.</sZ></inist:fA14><country>Suisse</country></affiliation></author><author><name sortKey="Whibley, Annabel" sort="Whibley, Annabel" uniqKey="Whibley A" first="Annabel" last="Whibley">Annabel Whibley</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>CNRS UMR 7205, Museum National d'Histoire Naturelle, CP50, 45 Rue Buffon</s1><s2>75005 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Becuwe, Michel" sort="Becuwe, Michel" uniqKey="Becuwe M" first="Michel" last="Becuwe">Michel Becuwe</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, King's Buildings, West Mains Road</s1><s2>Edinburgh EH9 3JT</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Baxter, Simon W" sort="Baxter, Simon W" uniqKey="Baxter S" first="Simon W." last="Baxter">Simon W. Baxter</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Zoology, University of Cambridge, Downing Street</s1><s2>Cambridge CB2 3EJ</s2><s3>GBR</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Ferguson, Laura" sort="Ferguson, Laura" uniqKey="Ferguson L" first="Laura" last="Ferguson">Laura Ferguson</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Zoology, University of Cambridge, Downing Street</s1><s2>Cambridge CB2 3EJ</s2><s3>GBR</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Wilkinson, Paul A" sort="Wilkinson, Paul A" uniqKey="Wilkinson P" first="Paul A." last="Wilkinson">Paul A. Wilkinson</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Centre for Ecology and Conservation, School of Biosciences, University of Exeter, Cornwall Campus, Penryn</s1><s2>Cornwall TR10 9EZ</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Salazar, Camilo" sort="Salazar, Camilo" uniqKey="Salazar C" first="Camilo" last="Salazar">Camilo Salazar</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Smithsonian Tropical Research Institute, NAOS island, Causeway Amador</s1><s2>Panamá</s2><s3>PAN</s3><sZ>12 aut.</sZ></inist:fA14><country>Panama</country></affiliation></author><author><name sortKey="Davidson, Claire" sort="Davidson, Claire" uniqKey="Davidson C" first="Claire" last="Davidson">Claire Davidson</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>The Wellcome Trust Sanger Institute</s1><s2>Hinxton, Cambridge CB10 1HH</s2><s3>GBR</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Clark, Richard" sort="Clark, Richard" uniqKey="Clark R" first="Richard" last="Clark">Richard Clark</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>The Wellcome Trust Sanger Institute</s1><s2>Hinxton, Cambridge CB10 1HH</s2><s3>GBR</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Quail, Michael A" sort="Quail, Michael A" uniqKey="Quail M" first="Michael A." last="Quail">Michael A. Quail</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>The Wellcome Trust Sanger Institute</s1><s2>Hinxton, Cambridge CB10 1HH</s2><s3>GBR</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Beasley, Helen" sort="Beasley, Helen" uniqKey="Beasley H" first="Helen" last="Beasley">Helen Beasley</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>The Wellcome Trust Sanger Institute</s1><s2>Hinxton, Cambridge CB10 1HH</s2><s3>GBR</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Glithero, Rebecca" sort="Glithero, Rebecca" uniqKey="Glithero R" first="Rebecca" last="Glithero">Rebecca Glithero</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>The Wellcome Trust Sanger Institute</s1><s2>Hinxton, Cambridge CB10 1HH</s2><s3>GBR</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Lloyd, Christine" sort="Lloyd, Christine" uniqKey="Lloyd C" first="Christine" last="Lloyd">Christine Lloyd</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>The Wellcome Trust Sanger Institute</s1><s2>Hinxton, Cambridge CB10 1HH</s2><s3>GBR</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Sims, Sarah" sort="Sims, Sarah" uniqKey="Sims S" first="Sarah" last="Sims">Sarah Sims</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>The Wellcome Trust Sanger Institute</s1><s2>Hinxton, Cambridge CB10 1HH</s2><s3>GBR</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Jones, Matthew C" sort="Jones, Matthew C" uniqKey="Jones M" first="Matthew C." last="Jones">Matthew C. Jones</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>The Wellcome Trust Sanger Institute</s1><s2>Hinxton, Cambridge CB10 1HH</s2><s3>GBR</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Rogers, Jane" sort="Rogers, Jane" uniqKey="Rogers J" first="Jane" last="Rogers">Jane Rogers</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>The Wellcome Trust Sanger Institute</s1><s2>Hinxton, Cambridge CB10 1HH</s2><s3>GBR</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Jiggins, Chris D" sort="Jiggins, Chris D" uniqKey="Jiggins C" first="Chris D." last="Jiggins">Chris D. Jiggins</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Zoology, University of Cambridge, Downing Street</s1><s2>Cambridge CB2 3EJ</s2><s3>GBR</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Ffrench Constant, Richard H" sort="Ffrench Constant, Richard H" uniqKey="Ffrench Constant R" first="Richard H." last="Ffrench-Constant">Richard H. Ffrench-Constant</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Centre for Ecology and Conservation, School of Biosciences, University of Exeter, Cornwall Campus, Penryn</s1><s2>Cornwall TR10 9EZ</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author></analytic><series><title level="j" type="main">Nature : (London)</title><title level="j" type="abbreviated">Nature : (Lond.)</title><idno type="ISSN">0028-0836</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Nature : (London)</title><title level="j" type="abbreviated">Nature : (Lond.)</title><idno type="ISSN">0028-0836</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coexistence</term><term>Gene</term><term>Gene rearrangement</term><term>Lepidoptera</term><term>Mimetism</term><term>Morphology</term><term>Phenotype</term><term>Polymorphism</term><term>Wing</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Réarrangement génique</term><term>Polymorphisme</term><term>Gène</term><term>Mimétisme</term><term>Morphologie</term><term>Aile</term><term>Coexistence</term><term>Phénotype</term><term>Lepidoptera</term><term>Heliconius numata</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Supergenes are tight clusters of loci that facilitate the co-segregation of adaptive variation, providing integrated control of complex adaptive phenotypes'. Polymorphic supergenes, in which specific combinations of traits are maintained within a single population, were first described for 'pin' and 'thrum' floral types in Primula<sup>1</sup> and Fagopyrum<sup>2</sup>, but classic examples are also found in insect mimicry<sup>3-5</sup> and snail morphology<sup>6</sup>. Understanding the evolutionary mechanisms that generate these co-adapted gene sets, as well as the mode of limiting the production of unfit recombinant forms, remains a substantial challenge<sup>7-10</sup>. Here we show that individual wing-pattern morphs in the polymorphic mimetic butterfly Heliconius numata are associated with different genomic rearrangements at the supergene locus P. These rearrangements tighten the genetic linkage between at least two colour-pattern loci that are known to recombine in closely related species<sup>9-11</sup>, with complete suppression of recombination being observed in experimental crosses across a 400-kilobase interval containing at least 18 genes. In natural populations, notable patterns of linkage disequilibrium (LD) are observed across the entire P region. The resulting divergent haplotype clades and inversion breakpoints are found in complete association with wing-pattern morphs. Our results indicate that allelic combinations at known wing-patterning loci have become locked together in a polymorphic rearrangement at the P locus, forming a supergene that acts as a simple switch between complex adaptive phenotypes found in sympatry. These findings highlight how genomic rearrangements can have a central role in the coexistence of adaptive phenotypes involving several genes acting in concert, by locally limiting recombination and gene flow.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0028-0836</s0></fA01><fA02 i1="01"><s0>NATUAS</s0></fA02><fA03 i2="1"><s0>Nature : (Lond.)</s0></fA03><fA05><s2>477</s2></fA05><fA06><s2>7363</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Chromosomal rearrangements maintain a polymorphic supergene controlling butterfly mimicry</s1></fA08><fA11 i1="01" i2="1"><s1>JORON (Mathieu)</s1></fA11><fA11 i1="02" i2="1"><s1>FREZAL (Lise)</s1></fA11><fA11 i1="03" i2="1"><s1>JONES (Robert T.)</s1></fA11><fA11 i1="04" i2="1"><s1>CHAMBERLAIN (Nicola L.)</s1></fA11><fA11 i1="05" i2="1"><s1>LEE (Siu F.)</s1></fA11><fA11 i1="06" i2="1"><s1>HAAG (Christoph R.)</s1></fA11><fA11 i1="07" i2="1"><s1>WHIBLEY (Annabel)</s1></fA11><fA11 i1="08" i2="1"><s1>BECUWE (Michel)</s1></fA11><fA11 i1="09" i2="1"><s1>BAXTER (Simon W.)</s1></fA11><fA11 i1="10" i2="1"><s1>FERGUSON (Laura)</s1></fA11><fA11 i1="11" i2="1"><s1>WILKINSON (Paul A.)</s1></fA11><fA11 i1="12" i2="1"><s1>SALAZAR (Camilo)</s1></fA11><fA11 i1="13" i2="1"><s1>DAVIDSON (Claire)</s1></fA11><fA11 i1="14" i2="1"><s1>CLARK (Richard)</s1></fA11><fA11 i1="15" i2="1"><s1>QUAIL (Michael A.)</s1></fA11><fA11 i1="16" i2="1"><s1>BEASLEY (Helen)</s1></fA11><fA11 i1="17" i2="1"><s1>GLITHERO (Rebecca)</s1></fA11><fA11 i1="18" i2="1"><s1>LLOYD (Christine)</s1></fA11><fA11 i1="19" i2="1"><s1>SIMS (Sarah)</s1></fA11><fA11 i1="20" i2="1"><s1>JONES (Matthew C.)</s1></fA11><fA11 i1="21" i2="1"><s1>ROGERS (Jane)</s1></fA11><fA11 i1="22" i2="1"><s1>JIGGINS (Chris D.)</s1></fA11><fA11 i1="23" i2="1"><s1>FFRENCH-CONSTANT (Richard H.)</s1></fA11><fA14 i1="01"><s1>CNRS UMR 7205, Museum National d'Histoire Naturelle, CP50, 45 Rue Buffon</s1><s2>75005 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="02"><s1>Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, King's Buildings, West Mains Road</s1><s2>Edinburgh EH9 3JT</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ></fA14><fA14 i1="03"><s1>Institute of Biology, Leiden University, Postbus 9505</s1><s2>2300 RA Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ></fA14><fA14 i1="04"><s1>Centre for Ecology and Conservation, School of Biosciences, University of Exeter, Cornwall Campus, Penryn</s1><s2>Cornwall TR10 9EZ</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ><sZ>23 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Genetics, Bio21 Institute, University of Melbourne, 30 Flemington Road</s1><s2>Parkville, 3010 Victoria</s2><s3>AUS</s3><sZ>5 aut.</sZ></fA14><fA14 i1="06"><s1>Department of Biology, Ecology and Evolution, University of Fribourg, Chemin du Musee 10</s1><s2>1700 Fribourg</s2><s3>CHE</s3><sZ>6 aut.</sZ></fA14><fA14 i1="07"><s1>Department of Zoology, University of Cambridge, Downing Street</s1><s2>Cambridge CB2 3EJ</s2><s3>GBR</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>22 aut.</sZ></fA14><fA14 i1="08"><s1>Smithsonian Tropical Research Institute, NAOS island, Causeway Amador</s1><s2>Panamá</s2><s3>PAN</s3><sZ>12 aut.</sZ></fA14><fA14 i1="09"><s1>The Wellcome Trust Sanger Institute</s1><s2>Hinxton, Cambridge CB10 1HH</s2><s3>GBR</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ></fA14><fA20><s1>203-206</s1></fA20><fA21><s1>2011</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>142</s2><s5>354000508979910180</s5></fA43><fA44><s0>0000</s0><s1>© 2011 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>30 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>11-0403590</s0></fA47><fA60><s1>P</s1><s3>CR</s3></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Nature : (London)</s0></fA64><fA66 i1="01"><s0>GBR</s0></fA66><fC01 i1="01" l="ENG"><s0>Supergenes are tight clusters of loci that facilitate the co-segregation of adaptive variation, providing integrated control of complex adaptive phenotypes'. Polymorphic supergenes, in which specific combinations of traits are maintained within a single population, were first described for 'pin' and 'thrum' floral types in Primula<sup>1</sup> and Fagopyrum<sup>2</sup>, but classic examples are also found in insect mimicry<sup>3-5</sup> and snail morphology<sup>6</sup>. Understanding the evolutionary mechanisms that generate these co-adapted gene sets, as well as the mode of limiting the production of unfit recombinant forms, remains a substantial challenge<sup>7-10</sup>. Here we show that individual wing-pattern morphs in the polymorphic mimetic butterfly Heliconius numata are associated with different genomic rearrangements at the supergene locus P. These rearrangements tighten the genetic linkage between at least two colour-pattern loci that are known to recombine in closely related species<sup>9-11</sup>, with complete suppression of recombination being observed in experimental crosses across a 400-kilobase interval containing at least 18 genes. In natural populations, notable patterns of linkage disequilibrium (LD) are observed across the entire P region. The resulting divergent haplotype clades and inversion breakpoints are found in complete association with wing-pattern morphs. Our results indicate that allelic combinations at known wing-patterning loci have become locked together in a polymorphic rearrangement at the P locus, forming a supergene that acts as a simple switch between complex adaptive phenotypes found in sympatry. These findings highlight how genomic rearrangements can have a central role in the coexistence of adaptive phenotypes involving several genes acting in concert, by locally limiting recombination and gene flow.</s0></fC01><fC02 i1="01" i2="X"><s0>002A07C01A</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Réarrangement génique</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Gene rearrangement</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Redisposición génica</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Polymorphisme</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Polymorphism</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Polimorfismo</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Gène</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Gene</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Gen</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Mimétisme</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Mimetism</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Mimetismo</s0><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Morphologie</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Morphology</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Morfología</s0><s5>05</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Aile</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Wing</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Ala</s0><s5>06</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Coexistence</s0><s5>07</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Coexistence</s0><s5>07</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Coexistencia</s0><s5>07</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Phénotype</s0><s5>08</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Phenotype</s0><s5>08</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Fenotipo</s0><s5>08</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Lepidoptera</s0><s2>NS</s2><s5>55</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Lepidoptera</s0><s2>NS</s2><s5>55</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Lepidoptera</s0><s2>NS</s2><s5>55</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>Heliconius numata</s0><s4>INC</s4><s5>87</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Insecta</s0><s2>NS</s2></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Insecta</s0><s2>NS</s2></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Insecta</s0><s2>NS</s2></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Arthropoda</s0><s2>NS</s2></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Arthropoda</s0><s2>NS</s2></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Arthropoda</s0><s2>NS</s2></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Invertebrata</s0><s2>NS</s2></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Invertebrata</s0><s2>NS</s2></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Invertebrata</s0><s2>NS</s2></fC07><fN21><s1>276</s1></fN21></pA></standard></inist></record>Pour manipuler ce document sous Unix (Dilib)
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