AustralieFrV1, PascalFrancis, Curation, bibRecord, 004564

Suicidal Behavior Is Associated with Reduced Corpus Callosum Area

Identifieur interne : 004564 ( PascalFrancis/Curation ); précédent : 004563; suivant : 004565

Suicidal Behavior Is Associated with Reduced Corpus Callosum Area

Auteurs : Fabienne Cyprien [France] ; Philippe Courtet [France] ; Alain Malafosse [France, Suisse] ; Jerome Maller [Australie] ; Chantal Meslin [Australie] ; Alain Bonafe [France] ; Emmanuelle Le Bars [France] ; Nicolas Menjot De Champfleur [France] ; Karen Ritchie [France, Royaume-Uni] ; Sylvaine Artero [France]

Source :

Biological psychiatry : (1969) [ 0006-3223 ] ; 2011.

RBID : Pascal:11-0394998

Descripteurs français

Pascal (Inist)
- Suicide, Tentative suicide, Corps calleux, Imagerie RMN.
Wicri :
- topic : Suicide.

English descriptors

KwdEn :
- Corpus callosum, Nuclear magnetic resonance imaging, Suicide, Suicide attempt.

Abstract

Background: Corpus callosum (CC) size has been associated with cognitive and emotional deficits in a range of neuropsychiatric and mood disorders. As such deficits are also found in suicidal behavior, we investigated specifically the association between CC atrophy and suicidal behavior. Methods: We studied 435 right-handed individuals without dementia from a cohort of community-dwelling persons aged 65 years and over (the ESPRIT study). They were divided in three groups: suicide attempters (n = 21), affective control subjects (AC) (n = 180) without history of suicide attempt but with a history of depression, and healthy control subjects (HC) (n = 234). T1-weighted magnetic resonance images were traced to measure the midsagittal areas of the anterior, mid, and posterior CC. Multivariate analysis of covariance was used to compare CC areas in the three groups. Results: Multivariate analyses adjusted for age, gender, childhood trauma, head trauma, and total brain volume showed that the area of the posterior third of CC was significantly smaller in suicide attempters than in AC (p = .020) and HC (p = .010) individuals. No significant differences were found between AC and HC. No differences were found for the anterior and mid thirds of the CC. Conclusions: Our findings emphasize a reduced size of the posterior third of the CC in subjects with a history of suicide, suggesting a diminished interhemispheric connectivity and a possible role of CC in the pathophysiology of suicidal behavior. Further studies are needed to strengthen these results and clarify the underlying cellular changes leading to these morphometric differences.

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A08	`01`	`1`	`ENG`	`@1 Suicidal Behavior Is Associated with Reduced Corpus Callosum Area`
A09	`01`	`1`	`ENG`	`@1 Neural Connectivity, Ruminations, and Suicide`
A11	`01`	`1`		`@1 CYPRIEN (Fabienne)`
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A11	`03`	`1`		`@1 MALAFOSSE (Alain)`
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A11	`05`	`1`		`@1 MESLIN (Chantal)`
A11	`06`	`1`		`@1 BONAFE (Alain)`
A11	`07`	`1`		`@1 LE BARS (Emmanuelle)`
A11	`08`	`1`		`@1 MENJOT DE CHAMPFLEUR (Nicolas)`
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A14	`04`			`@1 Department of Psychiatry, University of Geneva @2 Geneva @3 CHE @Z 3 aut.`
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A14	`07`			`@1 Faculty of Medicine (KR), Imperial College, St. Mary's Hospital @2 London @3 GBR @Z 9 aut.`
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C01	`01`		`ENG`	@0 Background: Corpus callosum (CC) size has been associated with cognitive and emotional deficits in a range of neuropsychiatric and mood disorders. As such deficits are also found in suicidal behavior, we investigated specifically the association between CC atrophy and suicidal behavior. Methods: We studied 435 right-handed individuals without dementia from a cohort of community-dwelling persons aged 65 years and over (the ESPRIT study). They were divided in three groups: suicide attempters (n = 21), affective control subjects (AC) (n = 180) without history of suicide attempt but with a history of depression, and healthy control subjects (HC) (n = 234). T1-weighted magnetic resonance images were traced to measure the midsagittal areas of the anterior, mid, and posterior CC. Multivariate analysis of covariance was used to compare CC areas in the three groups. Results: Multivariate analyses adjusted for age, gender, childhood trauma, head trauma, and total brain volume showed that the area of the posterior third of CC was significantly smaller in suicide attempters than in AC (p = .020) and HC (p = .010) individuals. No significant differences were found between AC and HC. No differences were found for the anterior and mid thirds of the CC. Conclusions: Our findings emphasize a reduced size of the posterior third of the CC in subjects with a history of suicide, suggesting a diminished interhemispheric connectivity and a possible role of CC in the pathophysiology of suicidal behavior. Further studies are needed to strengthen these results and clarify the underlying cellular changes leading to these morphometric differences.
C02	`01`	`X`		`@0 002B18C11`
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C03	`01`	`X`	`ENG`	`@0 Suicide @5 01`
C03	`01`	`X`	`SPA`	`@0 Suicidio @5 01`
C03	`02`	`X`	`FRE`	`@0 Tentative suicide @5 02`
C03	`02`	`X`	`ENG`	`@0 Suicide attempt @5 02`
C03	`02`	`X`	`SPA`	`@0 Tentativa suicidio @5 02`
C03	`03`	`X`	`FRE`	`@0 Corps calleux @5 03`
C03	`03`	`X`	`ENG`	`@0 Corpus callosum @5 03`
C03	`03`	`X`	`SPA`	`@0 Cuerpo calloso @5 03`
C03	`04`	`X`	`FRE`	`@0 Imagerie RMN @5 04`
C03	`04`	`X`	`ENG`	`@0 Nuclear magnetic resonance imaging @5 04`
C03	`04`	`X`	`SPA`	`@0 Imaginería RMN @5 04`
C07	`01`	`X`	`FRE`	`@0 Encéphale @5 37`
C07	`01`	`X`	`ENG`	`@0 Encephalon @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo @5 37`
C07	`02`	`X`	`FRE`	`@0 Système nerveux central @5 38`
C07	`02`	`X`	`ENG`	`@0 Central nervous system @5 38`
C07	`02`	`X`	`SPA`	`@0 Sistema nervioso central @5 38`
C07	`03`	`X`	`FRE`	`@0 Imagerie médicale @5 39`
C07	`03`	`X`	`ENG`	`@0 Medical imagery @5 39`
C07	`03`	`X`	`SPA`	`@0 Imaginería médica @5 39`
N21				`@1 269`
N44	`01`			`@1 OTO`
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Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Suicidal Behavior Is Associated with Reduced Corpus Callosum Area</title>
<author><name sortKey="Cyprien, Fabienne" sort="Cyprien, Fabienne" uniqKey="Cyprien F" first="Fabienne" last="Cyprien">Fabienne Cyprien</name>
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<author><name sortKey="Courtet, Philippe" sort="Courtet, Philippe" uniqKey="Courtet P" first="Philippe" last="Courtet">Philippe Courtet</name>
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<author><name sortKey="Malafosse, Alain" sort="Malafosse, Alain" uniqKey="Malafosse A" first="Alain" last="Malafosse">Alain Malafosse</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institut National de la Sante et de la Recherche Medicale (INSERM), Unit 1061, Neuropsychiatry, Epidemiological and Clinical Research</s1>
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<s3>FRA</s3>
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<country>France</country>
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<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>La Colombière Hospital; University of Montpellier I</s1>
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<country>France</country>
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<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Psychiatry, University of Geneva</s1>
<s2>Geneva</s2>
<s3>CHE</s3>
<sZ>3 aut.</sZ>
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<country>Suisse</country>
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</author>
<author><name sortKey="Maller, Jerome" sort="Maller, Jerome" uniqKey="Maller J" first="Jerome" last="Maller">Jerome Maller</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Monash Alfred Psychiatry Research Centre, The Alfred and Monash University School of Psychology and Psychiatry</s1>
<s2>Melbourne</s2>
<s3>AUS</s3>
<sZ>4 aut.</sZ>
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<country>Australie</country>
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</author>
<author><name sortKey="Meslin, Chantal" sort="Meslin, Chantal" uniqKey="Meslin C" first="Chantal" last="Meslin">Chantal Meslin</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Centre for Mental Health Research, Australian National University</s1>
<s2>Canberra</s2>
<s3>AUS</s3>
<sZ>5 aut.</sZ>
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<country>Australie</country>
</affiliation>
</author>
<author><name sortKey="Bonafe, Alain" sort="Bonafe, Alain" uniqKey="Bonafe A" first="Alain" last="Bonafe">Alain Bonafe</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Centre Hospitalier Regional Universitaire de Montpellier</s1>
<s2>Montpellier</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
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<country>France</country>
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</author>
<author><name sortKey="Le Bars, Emmanuelle" sort="Le Bars, Emmanuelle" uniqKey="Le Bars E" first="Emmanuelle" last="Le Bars">Emmanuelle Le Bars</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>La Colombière Hospital; University of Montpellier I</s1>
<s2>Montpellier</s2>
<s3>FRA</s3>
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<country>France</country>
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<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Centre Hospitalier Regional Universitaire de Montpellier</s1>
<s2>Montpellier</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
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<country>France</country>
</affiliation>
</author>
<author><name sortKey="Menjot De Champfleur, Nicolas" sort="Menjot De Champfleur, Nicolas" uniqKey="Menjot De Champfleur N" first="Nicolas" last="Menjot De Champfleur">Nicolas Menjot De Champfleur</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>La Colombière Hospital; University of Montpellier I</s1>
<s2>Montpellier</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Centre Hospitalier Regional Universitaire de Montpellier</s1>
<s2>Montpellier</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institut National de la Sante et de la Recherche Medicale (INSERM), Unit 1061, Neuropsychiatry, Epidemiological and Clinical Research</s1>
<s2>Montpellier</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>La Colombière Hospital; University of Montpellier I</s1>
<s2>Montpellier</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Faculty of Medicine (KR), Imperial College, St. Mary's Hospital</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author><name sortKey="Artero, Sylvaine" sort="Artero, Sylvaine" uniqKey="Artero S" first="Sylvaine" last="Artero">Sylvaine Artero</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institut National de la Sante et de la Recherche Medicale (INSERM), Unit 1061, Neuropsychiatry, Epidemiological and Clinical Research</s1>
<s2>Montpellier</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>La Colombière Hospital; University of Montpellier I</s1>
<s2>Montpellier</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
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<series><title level="j" type="main">Biological psychiatry : (1969)</title>
<title level="j" type="abbreviated">Biol. psychiatry : (1969)</title>
<idno type="ISSN">0006-3223</idno>
<imprint><date when="2011">2011</date>
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<seriesStmt><title level="j" type="main">Biological psychiatry : (1969)</title>
<title level="j" type="abbreviated">Biol. psychiatry : (1969)</title>
<idno type="ISSN">0006-3223</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Corpus callosum</term>
<term>Nuclear magnetic resonance imaging</term>
<term>Suicide</term>
<term>Suicide attempt</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Suicide</term>
<term>Tentative suicide</term>
<term>Corps calleux</term>
<term>Imagerie RMN</term>
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<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Suicide</term>
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<front><div type="abstract" xml:lang="en">Background: Corpus callosum (CC) size has been associated with cognitive and emotional deficits in a range of neuropsychiatric and mood disorders. As such deficits are also found in suicidal behavior, we investigated specifically the association between CC atrophy and suicidal behavior. Methods: We studied 435 right-handed individuals without dementia from a cohort of community-dwelling persons aged 65 years and over (the ESPRIT study). They were divided in three groups: suicide attempters (n = 21), affective control subjects (AC) (n = 180) without history of suicide attempt but with a history of depression, and healthy control subjects (HC) (n = 234). T1-weighted magnetic resonance images were traced to measure the midsagittal areas of the anterior, mid, and posterior CC. Multivariate analysis of covariance was used to compare CC areas in the three groups. Results: Multivariate analyses adjusted for age, gender, childhood trauma, head trauma, and total brain volume showed that the area of the posterior third of CC was significantly smaller in suicide attempters than in AC (p = .020) and HC (p = .010) individuals. No significant differences were found between AC and HC. No differences were found for the anterior and mid thirds of the CC. Conclusions: Our findings emphasize a reduced size of the posterior third of the CC in subjects with a history of suicide, suggesting a diminished interhemispheric connectivity and a possible role of CC in the pathophysiology of suicidal behavior. Further studies are needed to strengthen these results and clarify the underlying cellular changes leading to these morphometric differences.</div>
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<fA14 i1="01"><s1>Institut National de la Sante et de la Recherche Medicale (INSERM), Unit 1061, Neuropsychiatry, Epidemiological and Clinical Research</s1>
<s2>Montpellier</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>9 aut.</sZ>
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<sZ>2 aut.</sZ>
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<fA14 i1="04"><s1>Department of Psychiatry, University of Geneva</s1>
<s2>Geneva</s2>
<s3>CHE</s3>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Monash Alfred Psychiatry Research Centre, The Alfred and Monash University School of Psychology and Psychiatry</s1>
<s2>Melbourne</s2>
<s3>AUS</s3>
<sZ>4 aut.</sZ>
</fA14>
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<sZ>5 aut.</sZ>
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<fA14 i1="07"><s1>Faculty of Medicine (KR), Imperial College, St. Mary's Hospital</s1>
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<sZ>9 aut.</sZ>
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<fC01 i1="01" l="ENG"><s0>Background: Corpus callosum (CC) size has been associated with cognitive and emotional deficits in a range of neuropsychiatric and mood disorders. As such deficits are also found in suicidal behavior, we investigated specifically the association between CC atrophy and suicidal behavior. Methods: We studied 435 right-handed individuals without dementia from a cohort of community-dwelling persons aged 65 years and over (the ESPRIT study). They were divided in three groups: suicide attempters (n = 21), affective control subjects (AC) (n = 180) without history of suicide attempt but with a history of depression, and healthy control subjects (HC) (n = 234). T1-weighted magnetic resonance images were traced to measure the midsagittal areas of the anterior, mid, and posterior CC. Multivariate analysis of covariance was used to compare CC areas in the three groups. Results: Multivariate analyses adjusted for age, gender, childhood trauma, head trauma, and total brain volume showed that the area of the posterior third of CC was significantly smaller in suicide attempters than in AC (p = .020) and HC (p = .010) individuals. No significant differences were found between AC and HC. No differences were found for the anterior and mid thirds of the CC. Conclusions: Our findings emphasize a reduced size of the posterior third of the CC in subjects with a history of suicide, suggesting a diminished interhemispheric connectivity and a possible role of CC in the pathophysiology of suicidal behavior. Further studies are needed to strengthen these results and clarify the underlying cellular changes leading to these morphometric differences.</s0>
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Suicidal Behavior Is Associated with Reduced Corpus Callosum Area

Suicidal Behavior Is Associated with Reduced Corpus Callosum Area

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