Conversion of Long-Term Kidney Transplant Recipients From Calcineurin Inhibitor Therapy to Everolimus: A Randomized, Multicenter, 24-Month Study
Identifieur interne : 004524 ( PascalFrancis/Curation ); précédent : 004523; suivant : 004525Conversion of Long-Term Kidney Transplant Recipients From Calcineurin Inhibitor Therapy to Everolimus: A Randomized, Multicenter, 24-Month Study
Auteurs : Hallvard Holdaas [Norvège] ; Lionel Rostaing [France] ; Daniel Seron [Espagne] ; Edward Cole [Canada] ; Jeremy Chapman [Australie] ; Bengt Fellstr M [Suède] ; Erik H. Strom [Norvège] ; Alan Jardine [Royaume-Uni] ; Karsten Midtvedt [Norvège] ; Uwe Machein [Suisse] ; Bettina Ulbricht [Suisse] ; Alexander Karpov [Suisse] ; Philip J. O'Connell [Australie]Source :
- Transplantation [ 0041-1337 ] ; 2011.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Background. Benefits of conversion from calcineurin inhibitor (CNI) to mammalian target of rapamycin inhibitor-based immunosuppression in long-term kidney transplant patients remain uncertain. Methods. ASCERTAIN was a 24-month, open-label, multicenter study. Kidney transplant patients more than 6 months posttransplant receiving CNI (baseline glomerular filtration rate [GFR] 30-70 mL/min/1.73 m2) were randomized to everolimus with CNI elimination (n= 127) or CNI minimization (n= 144), or continued CNI unchanged (controls, n= 123) to assess the effect on measured GFR at month 24 after randomization. Results. Renal function was stable in all groups to month 24. Mean measured GFR at month 24, the primary endpoint, was 48.0±22.0 mL/min/1.73 m2, 46.6±21.1 mL/min/1.73 m2, and 46.0±20.4 mL/min/1.73 m2 in the CNI elimination, CNI minimization, and control groups, respectively. Differences between CNI elimination (1.12 mL/min/1.73 m2, 95% confidence interval [CI] -3.51 to 5.76, P=0.63) and CNI minimization (0.59 mL/min/1.73 m2, 95% CI -3.88 to 5.07, P=0.79) versus controls at month 24 were nonsignificant that is, the primary endpoint was not met. No efficacy endpoint differed significantly between groups. Post hoc analyses showed that patients with baseline creatinine clearance (CrCl) more than 50 mL/min had a significantly greater increase in measured GFR after CNI elimination versus controls (difference 11.4 mL/min/1.73 m2, 95% CI 2.1 to 20.8 mL/min/1.73 m2, P=0.017). Adverse events resulted in discontinuation in 36 (28.3%) CNI elimination patients, 24 (16.7%) CNI minimization patients, and 5 (4.1%) controls (P<0.001 vs. CNI elimination; P=0.020 vs. CNI minimization). Conclusion. Conversion to everolimus with CNI elimination or minimization a mean of 5.6 years after kidney transplantation had no overall renal benefit and was associated with more frequent adverse events and discontinuations. Patients with CrCl more than 50 mL/min may benefit from a change in therapy more than 6 months after renal transplantation.
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<author><name sortKey="Chapman, Jeremy" sort="Chapman, Jeremy" uniqKey="Chapman J" first="Jeremy" last="Chapman">Jeremy Chapman</name>
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<s2>New South Wales</s2>
<s3>AUS</s3>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Australie</country>
</affiliation>
</author>
<author><name sortKey="Fellstr M, Bengt" sort="Fellstr M, Bengt" uniqKey="Fellstr M B" first="Bengt" last="Fellstr M">Bengt Fellstr M</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Medical Science, Renal Unit, University Hospital</s1>
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<author><name sortKey="Strom, Erik H" sort="Strom, Erik H" uniqKey="Strom E" first="Erik H." last="Strom">Erik H. Strom</name>
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<author><name sortKey="Jardine, Alan" sort="Jardine, Alan" uniqKey="Jardine A" first="Alan" last="Jardine">Alan Jardine</name>
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<s2>Glasgow</s2>
<s3>GBR</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author><name sortKey="Midtvedt, Karsten" sort="Midtvedt, Karsten" uniqKey="Midtvedt K" first="Karsten" last="Midtvedt">Karsten Midtvedt</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Nephrology, Medical Department, Rikshospitalet, Oslo University Hospital</s1>
<s2>Oslo</s2>
<s3>NOR</s3>
<sZ>9 aut.</sZ>
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</affiliation>
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<author><name sortKey="Machein, Uwe" sort="Machein, Uwe" uniqKey="Machein U" first="Uwe" last="Machein">Uwe Machein</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Novartis Pharma AG</s1>
<s2>Basel</s2>
<s3>CHE</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Suisse</country>
</affiliation>
</author>
<author><name sortKey="Ulbricht, Bettina" sort="Ulbricht, Bettina" uniqKey="Ulbricht B" first="Bettina" last="Ulbricht">Bettina Ulbricht</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Novartis Pharma AG</s1>
<s2>Basel</s2>
<s3>CHE</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Suisse</country>
</affiliation>
</author>
<author><name sortKey="Karpov, Alexander" sort="Karpov, Alexander" uniqKey="Karpov A" first="Alexander" last="Karpov">Alexander Karpov</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Novartis Pharma AG</s1>
<s2>Basel</s2>
<s3>CHE</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Suisse</country>
</affiliation>
</author>
<author><name sortKey="O Connell, Philip J" sort="O Connell, Philip J" uniqKey="O Connell P" first="Philip J." last="O'Connell">Philip J. O'Connell</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Centre for Transplant and Renal Research, Westmead Millennium Institute, University of Sydney at Westmead Hospital</s1>
<s2>New South Wales</s2>
<s3>AUS</s3>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Australie</country>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Transplantation</title>
<title level="j" type="abbreviated">Transplantation</title>
<idno type="ISSN">0041-1337</idno>
<imprint><date when="2011">2011</date>
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<seriesStmt><title level="j" type="main">Transplantation</title>
<title level="j" type="abbreviated">Transplantation</title>
<idno type="ISSN">0041-1337</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibacterial agent</term>
<term>Calcineurin inhibitor</term>
<term>Clinical trial</term>
<term>Conversion</term>
<term>Drug conversion</term>
<term>Everolimus</term>
<term>Graft</term>
<term>Homotransplantation</term>
<term>Immunosuppressive agent</term>
<term>Kidney</term>
<term>Long term</term>
<term>Multicenter study</term>
<term>Randomization</term>
<term>Transplantation</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Homotransplantation</term>
<term>Conversion</term>
<term>Changement médicament</term>
<term>Inhibiteur de la calcineurine</term>
<term>Long terme</term>
<term>Transplantation</term>
<term>Evérolimus</term>
<term>Rein</term>
<term>Traitement</term>
<term>Immunodépresseur</term>
<term>Randomisation</term>
<term>Essai clinique</term>
<term>Etude multicentrique</term>
<term>Greffe</term>
<term>Antibactérien</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en">Background. Benefits of conversion from calcineurin inhibitor (CNI) to mammalian target of rapamycin inhibitor-based immunosuppression in long-term kidney transplant patients remain uncertain. Methods. ASCERTAIN was a 24-month, open-label, multicenter study. Kidney transplant patients more than 6 months posttransplant receiving CNI (baseline glomerular filtration rate [GFR] 30-70 mL/min/1.73 m<sup>2</sup>
) were randomized to everolimus with CNI elimination (n= 127) or CNI minimization (n= 144), or continued CNI unchanged (controls, n= 123) to assess the effect on measured GFR at month 24 after randomization. Results. Renal function was stable in all groups to month 24. Mean measured GFR at month 24, the primary endpoint, was 48.0±22.0 mL/min/1.73 m<sup>2</sup>
, 46.6±21.1 mL/min/1.73 m<sup>2</sup>
, and 46.0±20.4 mL/min/1.73 m<sup>2</sup>
in the CNI elimination, CNI minimization, and control groups, respectively. Differences between CNI elimination (1.12 mL/min/1.73 m<sup>2</sup>
, 95% confidence interval [CI] -3.51 to 5.76, P=0.63) and CNI minimization (0.59 mL/min/1.73 m<sup>2</sup>
, 95% CI -3.88 to 5.07, P=0.79) versus controls at month 24 were nonsignificant that is, the primary endpoint was not met. No efficacy endpoint differed significantly between groups. Post hoc analyses showed that patients with baseline creatinine clearance (CrCl) more than 50 mL/min had a significantly greater increase in measured GFR after CNI elimination versus controls (difference 11.4 mL/min/1.73 m<sup>2</sup>
, 95% CI 2.1 to 20.8 mL/min/1.73 m<sup>2</sup>
, P=0.017). Adverse events resulted in discontinuation in 36 (28.3%) CNI elimination patients, 24 (16.7%) CNI minimization patients, and 5 (4.1%) controls (P<0.001 vs. CNI elimination; P=0.020 vs. CNI minimization). Conclusion. Conversion to everolimus with CNI elimination or minimization a mean of 5.6 years after kidney transplantation had no overall renal benefit and was associated with more frequent adverse events and discontinuations. Patients with CrCl more than 50 mL/min may benefit from a change in therapy more than 6 months after renal transplantation.</div>
</front>
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<fA11 i1="01" i2="1"><s1>HOLDAAS (Hallvard)</s1>
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<fA11 i1="02" i2="1"><s1>ROSTAING (Lionel)</s1>
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<fA11 i1="08" i2="1"><s1>JARDINE (Alan)</s1>
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<fA11 i1="09" i2="1"><s1>MIDTVEDT (Karsten)</s1>
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<fA11 i1="10" i2="1"><s1>MACHEIN (Uwe)</s1>
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</fA11>
<fA11 i1="13" i2="1"><s1>O'CONNELL (Philip J.)</s1>
</fA11>
<fA14 i1="01"><s1>Medical Department, Rikshospitalet, University of Oslo</s1>
<s2>Oslo</s2>
<s3>NOR</s3>
<sZ>1 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Nephrology Department, Hospital Vall d'Hebron, Universitat Autonoma Barcelona</s1>
<s3>ESP</s3>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Division of Nephrology, University of Toronto, Toronto General Hospital</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Centre for Transplant and Renal Research, Westmead Millennium Institute, University of Sydney at Westmead Hospital</s1>
<s2>New South Wales</s2>
<s3>AUS</s3>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Department of Medical Science, Renal Unit, University Hospital</s1>
<s2>Uppsala</s2>
<s3>SWE</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>Department of Pathology, Oslo University Hospital</s1>
<s2>Oslo</s2>
<s3>NOR</s3>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="08"><s1>Glasgow Cardiovascular Research Centre, Faculty of Medicine, University of Glasgow</s1>
<s2>Glasgow</s2>
<s3>GBR</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="09"><s1>Department of Nephrology, Medical Department, Rikshospitalet, Oslo University Hospital</s1>
<s2>Oslo</s2>
<s3>NOR</s3>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="10"><s1>Novartis Pharma AG</s1>
<s2>Basel</s2>
<s3>CHE</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</fA14>
<fA20><s1>410-418</s1>
</fA20>
<fA21><s1>2011</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>8318</s2>
<s5>354000500134820060</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2011 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>38 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>11-0381950</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Transplantation</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Background. Benefits of conversion from calcineurin inhibitor (CNI) to mammalian target of rapamycin inhibitor-based immunosuppression in long-term kidney transplant patients remain uncertain. Methods. ASCERTAIN was a 24-month, open-label, multicenter study. Kidney transplant patients more than 6 months posttransplant receiving CNI (baseline glomerular filtration rate [GFR] 30-70 mL/min/1.73 m<sup>2</sup>
) were randomized to everolimus with CNI elimination (n= 127) or CNI minimization (n= 144), or continued CNI unchanged (controls, n= 123) to assess the effect on measured GFR at month 24 after randomization. Results. Renal function was stable in all groups to month 24. Mean measured GFR at month 24, the primary endpoint, was 48.0±22.0 mL/min/1.73 m<sup>2</sup>
, 46.6±21.1 mL/min/1.73 m<sup>2</sup>
, and 46.0±20.4 mL/min/1.73 m<sup>2</sup>
in the CNI elimination, CNI minimization, and control groups, respectively. Differences between CNI elimination (1.12 mL/min/1.73 m<sup>2</sup>
, 95% confidence interval [CI] -3.51 to 5.76, P=0.63) and CNI minimization (0.59 mL/min/1.73 m<sup>2</sup>
, 95% CI -3.88 to 5.07, P=0.79) versus controls at month 24 were nonsignificant that is, the primary endpoint was not met. No efficacy endpoint differed significantly between groups. Post hoc analyses showed that patients with baseline creatinine clearance (CrCl) more than 50 mL/min had a significantly greater increase in measured GFR after CNI elimination versus controls (difference 11.4 mL/min/1.73 m<sup>2</sup>
, 95% CI 2.1 to 20.8 mL/min/1.73 m<sup>2</sup>
, P=0.017). Adverse events resulted in discontinuation in 36 (28.3%) CNI elimination patients, 24 (16.7%) CNI minimization patients, and 5 (4.1%) controls (P<0.001 vs. CNI elimination; P=0.020 vs. CNI minimization). Conclusion. Conversion to everolimus with CNI elimination or minimization a mean of 5.6 years after kidney transplantation had no overall renal benefit and was associated with more frequent adverse events and discontinuations. Patients with CrCl more than 50 mL/min may benefit from a change in therapy more than 6 months after renal transplantation.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B25</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002A06F</s0>
</fC02>
<fC02 i1="03" i2="X"><s0>002B02S02</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Homotransplantation</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Homotransplantation</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Homotrasplante</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Conversion</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Conversion</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Conversión</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Changement médicament</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Drug conversion</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Cambio medicamento</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Inhibiteur de la calcineurine</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Calcineurin inhibitor</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Inhibidor calcineurina</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Long terme</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Long term</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Largo plazo</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Transplantation</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Transplantation</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Trasplantación</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Evérolimus</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Everolimus</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Everolimus</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Rein</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Kidney</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Riñón</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Traitement</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Treatment</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Tratamiento</s0>
<s5>09</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Immunodépresseur</s0>
<s5>11</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Immunosuppressive agent</s0>
<s5>11</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Inmunodepresor</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Randomisation</s0>
<s5>12</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Randomization</s0>
<s5>12</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Aleatorización</s0>
<s5>12</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Essai clinique</s0>
<s5>17</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Clinical trial</s0>
<s5>17</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Ensayo clínico</s0>
<s5>17</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Etude multicentrique</s0>
<s5>18</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Multicenter study</s0>
<s5>18</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Estudio multicéntrico</s0>
<s5>18</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>Greffe</s0>
<s5>25</s5>
</fC03>
<fC03 i1="14" i2="X" l="ENG"><s0>Graft</s0>
<s5>25</s5>
</fC03>
<fC03 i1="14" i2="X" l="SPA"><s0>Injerto</s0>
<s5>25</s5>
</fC03>
<fC03 i1="15" i2="X" l="FRE"><s0>Antibactérien</s0>
<s5>26</s5>
</fC03>
<fC03 i1="15" i2="X" l="ENG"><s0>Antibacterial agent</s0>
<s5>26</s5>
</fC03>
<fC03 i1="15" i2="X" l="SPA"><s0>Antibacteriano</s0>
<s5>26</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Chirurgie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Surgery</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Cirugía</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Appareil urinaire</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Urinary system</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Aparato urinario</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Lactone</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Lactone</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Lactona</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Macrolide</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Macrolide</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Macrólido</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Inhibiteur synthèse protéique</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Protein synthesis inhibitor</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Inhibidor síntesis proteica</s0>
<s5>41</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Inhibiteur mTOR</s0>
<s4>INC</s4>
<s5>86</s5>
</fC07>
<fN21><s1>262</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>
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