Positron Emission Tomography-Computed Tomography (PET-CT) After Induction Therapy Is Highly Predictive of Patient Outcome in Follicular Lymphoma: Analysis of PET-CT in a Subset of PRIMA Trial Participants
Identifieur interne : 004520 ( PascalFrancis/Curation ); précédent : 004519; suivant : 004521Positron Emission Tomography-Computed Tomography (PET-CT) After Induction Therapy Is Highly Predictive of Patient Outcome in Follicular Lymphoma: Analysis of PET-CT in a Subset of PRIMA Trial Participants
Auteurs : Judith Trotman ; Marion Fournier [France] ; Thierry Lamy [France] ; John Francis Seymour [Australie] ; Anne Sonet [France] ; Andrea Janikova [République tchèque] ; Ofer Shpilberg [Israël] ; Emmanuel Gyan [France] ; Hervé Tilly [France] ; Jane Estell ; Cecily Forsyth [Australie] ; Didier Decaudin [France] ; Bettina Fabiani [France] ; Jean Gabarre [France] ; Bruno Salles [France] ; Eric Van Den Neste [Belgique] ; Danielle Canioni [France] ; Etienne Garin [France] ; Michael Fulham [Australie] ; Thierry Vander Borght [France] ; Gilles Salles [France]Source :
- Journal of clinical oncology [ 0732-183X ] ; 2011.
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Abstract
Purpose The utility of [18F]fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT) in assessing response at the end of induction therapy is well documented in Hodgkin's and diffuse large B-cell lymphomas, but its role in follicular lymphoma (FL) remains undetermined. We investigated the prognostic significance of PET-CT performed after first-line therapy in patients with FL treated in the prospective Primary Rituximab and Maintenance (PRIMA) study. Patients and Methods Results of PET-CT scans performed after induction immunochemotherapy were recorded retrospectively. Patients went on to either observation or rituximab maintenance per protocol independent of the PET-CT result. Patient characteristics and outcomes were then evaluated. Results Of 122 PET-CT scans performed at the end of the induction immunochemotherapy, 32 (26%) were reported as positive by the local investigator. Initial demographic or disease characteristics did not differ between PET-CT-positive (PET-positive) and PET-CT-negative (PET-negative) patients. PET status correlated with conventional response criteria (P<.001). Patients remaining PET positive had a significantly (P< .001) inferior progression-free survival at 42 months of 32.9% (95% CI, 17.2% to 49.5%) compared with 70.7% (95% CI, 59.3% to 79.4%) in those who became PET negative. PET status, but not conventional response (complete response or complete response unconfirmed v partial response) according to IWC 1999, was an independent predictive factor for lymphoma progression. The risk of death was also increased in PET-positive patients (hazard ratio 7.0; P = .0011). Conclusion [18F]FDG PET-CT status at the end of immunochemotherapy induction in patients with FL is strongly predictive of outcome and should be considered a meaningful clinical end point in future studies.
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Judith Trotman<affiliation><inist:fA14 i1="01"><s1>Concord Hospital</s1><s3>INC</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><wicri:noCountry>INC</wicri:noCountry></affiliation><affiliation><inist:fA14 i1="01"><s1>Concord Hospital</s1><s3>INC</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><wicri:noCountry>INC</wicri:noCountry></affiliation>Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Positron Emission Tomography-Computed Tomography (PET-CT) After Induction Therapy Is Highly Predictive of Patient Outcome in Follicular Lymphoma: Analysis of PET-CT in a Subset of PRIMA Trial Participants</title><author><name sortKey="Trotman, Judith" sort="Trotman, Judith" uniqKey="Trotman J" first="Judith" last="Trotman">Judith Trotman</name><affiliation><inist:fA14 i1="01"><s1>Concord Hospital</s1><s3>INC</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><wicri:noCountry>INC</wicri:noCountry></affiliation></author><author><name sortKey="Fournier, Marion" sort="Fournier, Marion" uniqKey="Fournier M" first="Marion" last="Fournier">Marion Fournier</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Hospices Civils de Lyon, Groupe d'Etude des Lymphomes de l'Adulte, Recherche Clinique, Hôpital Lyon sud, Pierre-Benite</s1><s3>FRA</s3><sZ>2 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Lamy, Thierry" sort="Lamy, Thierry" uniqKey="Lamy T" first="Thierry" last="Lamy">Thierry Lamy</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Centre Hospitalier Universitaire (CHU) de Rennes, L'Institut National de la Sante et de la Recherche Médicale (INSERM) U917, Universite de Rennes</s1><s3>FRA</s3><sZ>3 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Seymour, John Francis" sort="Seymour, John Francis" uniqKey="Seymour J" first="John Francis" last="Seymour">John Francis Seymour</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Peter MacCallum Cancer Center and University of Melbourne</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>4 aut.</sZ></inist:fA14><country>Australie</country></affiliation></author><author><name sortKey="Sonet, Anne" sort="Sonet, Anne" uniqKey="Sonet A" first="Anne" last="Sonet">Anne Sonet</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Universite Catholique de Louvain (UCL), Mont-Godinne Medical Center</s1><s2>Yvoir</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Janikova, Andrea" sort="Janikova, Andrea" uniqKey="Janikova A" first="Andrea" last="Janikova">Andrea Janikova</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>University Hospital Brno</s1><s2>Brno</s2><s3>CZE</s3><sZ>6 aut.</sZ></inist:fA14><country>République tchèque</country></affiliation></author><author><name sortKey="Shpilberg, Ofer" sort="Shpilberg, Ofer" uniqKey="Shpilberg O" first="Ofer" last="Shpilberg">Ofer Shpilberg</name><affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Rabin Medical Center</s1><s2>Petah-Tikva</s2><s3>ISR</s3><sZ>7 aut.</sZ></inist:fA14><country>Israël</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Tel Aviv University</s1><s2>Tel Aviv</s2><s3>ISR</s3><sZ>7 aut.</sZ></inist:fA14><country>Israël</country></affiliation></author><author><name sortKey="Gyan, Emmanuel" sort="Gyan, Emmanuel" uniqKey="Gyan E" first="Emmanuel" last="Gyan">Emmanuel Gyan</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>CHU de Tours</s1><s2>Tours</s2><s3>FRA</s3><sZ>8 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Tilly, Herve" sort="Tilly, Herve" uniqKey="Tilly H" first="Hervé" last="Tilly">Hervé Tilly</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Centre Henri Becquerel, INSERM U918, Universite de Rouen</s1><s2>Rouen</s2><s3>FRA</s3><sZ>9 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Estell, Jane" sort="Estell, Jane" uniqKey="Estell J" first="Jane" last="Estell">Jane Estell</name><affiliation><inist:fA14 i1="01"><s1>Concord Hospital</s1><s3>INC</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><wicri:noCountry>INC</wicri:noCountry></affiliation></author><author><name sortKey="Forsyth, Cecily" sort="Forsyth, Cecily" uniqKey="Forsyth C" first="Cecily" last="Forsyth">Cecily Forsyth</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Wyong Hospital</s1><s2>Kanwal</s2><s3>AUS</s3><sZ>11 aut.</sZ></inist:fA14><country>Australie</country></affiliation></author><author><name sortKey="Decaudin, Didier" sort="Decaudin, Didier" uniqKey="Decaudin D" first="Didier" last="Decaudin">Didier Decaudin</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Institut Curie</s1><s3>FRA</s3><sZ>12 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Fabiani, Bettina" sort="Fabiani, Bettina" uniqKey="Fabiani B" first="Bettina" last="Fabiani">Bettina Fabiani</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine</s1><s3>FRA</s3><sZ>13 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Gabarre, Jean" sort="Gabarre, Jean" uniqKey="Gabarre J" first="Jean" last="Gabarre">Jean Gabarre</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Hôpital de la Pitie Salpetriere</s1><s3>FRA</s3><sZ>14 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Salles, Bruno" sort="Salles, Bruno" uniqKey="Salles B" first="Bruno" last="Salles">Bruno Salles</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Centre Hospitalier</s1><s2>Chalons-Saône</s2><s3>FRA</s3><sZ>15 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Den Neste, Eric Van" sort="Den Neste, Eric Van" uniqKey="Den Neste E" first="Eric Van" last="Den Neste">Eric Van Den Neste</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>UCL Saint-Luc</s1><s2>Brussels</s2><s3>BEL</s3><sZ>16 aut.</sZ></inist:fA14><country>Belgique</country></affiliation></author><author><name sortKey="Canioni, Danielle" sort="Canioni, Danielle" uniqKey="Canioni D" first="Danielle" last="Canioni">Danielle Canioni</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Hôpital Necker</s1><s2>Paris</s2><s3>FRA</s3><sZ>17 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Garin, Etienne" sort="Garin, Etienne" uniqKey="Garin E" first="Etienne" last="Garin">Etienne Garin</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>CHU de Rennes</s1><s2>Rennes</s2><s3>FRA</s3><sZ>18 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Fulham, Michael" sort="Fulham, Michael" uniqKey="Fulham M" first="Michael" last="Fulham">Michael Fulham</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Royal Prince Alfred Hospital and Sydney Medical School, University of Sydney</s1><s2>Sydney</s2><s3>AUS</s3><sZ>19 aut.</sZ></inist:fA14><country>Australie</country></affiliation></author><author><name sortKey="Borght, Thierry Vander" sort="Borght, Thierry Vander" uniqKey="Borght T" first="Thierry Vander" last="Borght">Thierry Vander Borght</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Universite Catholique de Louvain (UCL), Mont-Godinne Medical Center</s1><s2>Yvoir</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Salles, Gilles" sort="Salles, Gilles" uniqKey="Salles G" first="Gilles" last="Salles">Gilles Salles</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Hospices Civils de Lyon, Universite Lyon1</s1><s3>FRA</s3><sZ>21 aut.</sZ></inist:fA14><country>France</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">11-0380678</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 11-0380678 INIST</idno><idno type="RBID">Pascal:11-0380678</idno><idno type="wicri:Area/PascalFrancis/Corpus">001A24</idno><idno type="wicri:Area/PascalFrancis/Curation">004520</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Positron Emission Tomography-Computed Tomography (PET-CT) After Induction Therapy Is Highly Predictive of Patient Outcome in Follicular Lymphoma: Analysis of PET-CT in a Subset of PRIMA Trial Participants</title><author><name sortKey="Trotman, Judith" sort="Trotman, Judith" uniqKey="Trotman J" first="Judith" last="Trotman">Judith Trotman</name><affiliation><inist:fA14 i1="01"><s1>Concord Hospital</s1><s3>INC</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><wicri:noCountry>INC</wicri:noCountry></affiliation></author><author><name sortKey="Fournier, Marion" sort="Fournier, Marion" uniqKey="Fournier M" first="Marion" last="Fournier">Marion Fournier</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Hospices Civils de Lyon, Groupe d'Etude des Lymphomes de l'Adulte, Recherche Clinique, Hôpital Lyon sud, Pierre-Benite</s1><s3>FRA</s3><sZ>2 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Lamy, Thierry" sort="Lamy, Thierry" uniqKey="Lamy T" first="Thierry" last="Lamy">Thierry Lamy</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Centre Hospitalier Universitaire (CHU) de Rennes, L'Institut National de la Sante et de la Recherche Médicale (INSERM) U917, Universite de Rennes</s1><s3>FRA</s3><sZ>3 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Seymour, John Francis" sort="Seymour, John Francis" uniqKey="Seymour J" first="John Francis" last="Seymour">John Francis Seymour</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Peter MacCallum Cancer Center and University of Melbourne</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>4 aut.</sZ></inist:fA14><country>Australie</country></affiliation></author><author><name sortKey="Sonet, Anne" sort="Sonet, Anne" uniqKey="Sonet A" first="Anne" last="Sonet">Anne Sonet</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Universite Catholique de Louvain (UCL), Mont-Godinne Medical Center</s1><s2>Yvoir</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Janikova, Andrea" sort="Janikova, Andrea" uniqKey="Janikova A" first="Andrea" last="Janikova">Andrea Janikova</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>University Hospital Brno</s1><s2>Brno</s2><s3>CZE</s3><sZ>6 aut.</sZ></inist:fA14><country>République tchèque</country></affiliation></author><author><name sortKey="Shpilberg, Ofer" sort="Shpilberg, Ofer" uniqKey="Shpilberg O" first="Ofer" last="Shpilberg">Ofer Shpilberg</name><affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Rabin Medical Center</s1><s2>Petah-Tikva</s2><s3>ISR</s3><sZ>7 aut.</sZ></inist:fA14><country>Israël</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Tel Aviv University</s1><s2>Tel Aviv</s2><s3>ISR</s3><sZ>7 aut.</sZ></inist:fA14><country>Israël</country></affiliation></author><author><name sortKey="Gyan, Emmanuel" sort="Gyan, Emmanuel" uniqKey="Gyan E" first="Emmanuel" last="Gyan">Emmanuel Gyan</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>CHU de Tours</s1><s2>Tours</s2><s3>FRA</s3><sZ>8 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Tilly, Herve" sort="Tilly, Herve" uniqKey="Tilly H" first="Hervé" last="Tilly">Hervé Tilly</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Centre Henri Becquerel, INSERM U918, Universite de Rouen</s1><s2>Rouen</s2><s3>FRA</s3><sZ>9 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Estell, Jane" sort="Estell, Jane" uniqKey="Estell J" first="Jane" last="Estell">Jane Estell</name><affiliation><inist:fA14 i1="01"><s1>Concord Hospital</s1><s3>INC</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><wicri:noCountry>INC</wicri:noCountry></affiliation></author><author><name sortKey="Forsyth, Cecily" sort="Forsyth, Cecily" uniqKey="Forsyth C" first="Cecily" last="Forsyth">Cecily Forsyth</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Wyong Hospital</s1><s2>Kanwal</s2><s3>AUS</s3><sZ>11 aut.</sZ></inist:fA14><country>Australie</country></affiliation></author><author><name sortKey="Decaudin, Didier" sort="Decaudin, Didier" uniqKey="Decaudin D" first="Didier" last="Decaudin">Didier Decaudin</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Institut Curie</s1><s3>FRA</s3><sZ>12 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Fabiani, Bettina" sort="Fabiani, Bettina" uniqKey="Fabiani B" first="Bettina" last="Fabiani">Bettina Fabiani</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine</s1><s3>FRA</s3><sZ>13 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Gabarre, Jean" sort="Gabarre, Jean" uniqKey="Gabarre J" first="Jean" last="Gabarre">Jean Gabarre</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Hôpital de la Pitie Salpetriere</s1><s3>FRA</s3><sZ>14 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Salles, Bruno" sort="Salles, Bruno" uniqKey="Salles B" first="Bruno" last="Salles">Bruno Salles</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Centre Hospitalier</s1><s2>Chalons-Saône</s2><s3>FRA</s3><sZ>15 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Den Neste, Eric Van" sort="Den Neste, Eric Van" uniqKey="Den Neste E" first="Eric Van" last="Den Neste">Eric Van Den Neste</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>UCL Saint-Luc</s1><s2>Brussels</s2><s3>BEL</s3><sZ>16 aut.</sZ></inist:fA14><country>Belgique</country></affiliation></author><author><name sortKey="Canioni, Danielle" sort="Canioni, Danielle" uniqKey="Canioni D" first="Danielle" last="Canioni">Danielle Canioni</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Hôpital Necker</s1><s2>Paris</s2><s3>FRA</s3><sZ>17 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Garin, Etienne" sort="Garin, Etienne" uniqKey="Garin E" first="Etienne" last="Garin">Etienne Garin</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>CHU de Rennes</s1><s2>Rennes</s2><s3>FRA</s3><sZ>18 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Fulham, Michael" sort="Fulham, Michael" uniqKey="Fulham M" first="Michael" last="Fulham">Michael Fulham</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Royal Prince Alfred Hospital and Sydney Medical School, University of Sydney</s1><s2>Sydney</s2><s3>AUS</s3><sZ>19 aut.</sZ></inist:fA14><country>Australie</country></affiliation></author><author><name sortKey="Borght, Thierry Vander" sort="Borght, Thierry Vander" uniqKey="Borght T" first="Thierry Vander" last="Borght">Thierry Vander Borght</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Universite Catholique de Louvain (UCL), Mont-Godinne Medical Center</s1><s2>Yvoir</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Salles, Gilles" sort="Salles, Gilles" uniqKey="Salles G" first="Gilles" last="Salles">Gilles Salles</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Hospices Civils de Lyon, Universite Lyon1</s1><s3>FRA</s3><sZ>21 aut.</sZ></inist:fA14><country>France</country></affiliation></author></analytic><series><title level="j" type="main">Journal of clinical oncology</title><title level="j" type="abbreviated">J. clin. oncol.</title><idno type="ISSN">0732-183X</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of clinical oncology</title><title level="j" type="abbreviated">J. clin. oncol.</title><idno type="ISSN">0732-183X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>B cell neoplasm</term><term>Cancerology</term><term>Clinical trial</term><term>Computerized axial tomography</term><term>Emission tomography</term><term>Follicular lymphoma</term><term>Human</term><term>Induction treatment</term><term>Lymphoid neoplasm</term><term>Positron emission tomography</term><term>Prognosis</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Tomoscintigraphie</term><term>Tomographie par émission de positons</term><term>Traitement induction</term><term>Tomodensitométrie</term><term>Homme</term><term>Pronostic</term><term>Lymphome folliculaire</term><term>Essai clinique</term><term>Cancérologie</term><term>Hémopathie maligne lymphoïde</term><term>Hémopathie lymphoïde B</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Purpose The utility of [<sup>18</sup>F]fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT) in assessing response at the end of induction therapy is well documented in Hodgkin's and diffuse large B-cell lymphomas, but its role in follicular lymphoma (FL) remains undetermined. We investigated the prognostic significance of PET-CT performed after first-line therapy in patients with FL treated in the prospective Primary Rituximab and Maintenance (PRIMA) study. Patients and Methods Results of PET-CT scans performed after induction immunochemotherapy were recorded retrospectively. Patients went on to either observation or rituximab maintenance per protocol independent of the PET-CT result. Patient characteristics and outcomes were then evaluated. Results Of 122 PET-CT scans performed at the end of the induction immunochemotherapy, 32 (26%) were reported as positive by the local investigator. Initial demographic or disease characteristics did not differ between PET-CT-positive (PET-positive) and PET-CT-negative (PET-negative) patients. PET status correlated with conventional response criteria (P<.001). Patients remaining PET positive had a significantly (P< .001) inferior progression-free survival at 42 months of 32.9% (95% CI, 17.2% to 49.5%) compared with 70.7% (95% CI, 59.3% to 79.4%) in those who became PET negative. PET status, but not conventional response (complete response or complete response unconfirmed v partial response) according to IWC 1999, was an independent predictive factor for lymphoma progression. The risk of death was also increased in PET-positive patients (hazard ratio 7.0; P = .0011). Conclusion [<sup>18</sup>F]FDG PET-CT status at the end of immunochemotherapy induction in patients with FL is strongly predictive of outcome and should be considered a meaningful clinical end point in future studies.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0732-183X</s0></fA01><fA03 i2="1"><s0>J. clin. oncol.</s0></fA03><fA05><s2>29</s2></fA05><fA06><s2>23</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Positron Emission Tomography-Computed Tomography (PET-CT) After Induction Therapy Is Highly Predictive of Patient Outcome in Follicular Lymphoma: Analysis of PET-CT in a Subset of PRIMA Trial Participants</s1></fA08><fA11 i1="01" i2="1"><s1>TROTMAN (Judith)</s1></fA11><fA11 i1="02" i2="1"><s1>FOURNIER (Marion)</s1></fA11><fA11 i1="03" i2="1"><s1>LAMY (Thierry)</s1></fA11><fA11 i1="04" i2="1"><s1>SEYMOUR (John Francis)</s1></fA11><fA11 i1="05" i2="1"><s1>SONET (Anne)</s1></fA11><fA11 i1="06" i2="1"><s1>JANIKOVA (Andrea)</s1></fA11><fA11 i1="07" i2="1"><s1>SHPILBERG (Ofer)</s1></fA11><fA11 i1="08" i2="1"><s1>GYAN (Emmanuel)</s1></fA11><fA11 i1="09" i2="1"><s1>TILLY (Hervé)</s1></fA11><fA11 i1="10" i2="1"><s1>ESTELL (Jane)</s1></fA11><fA11 i1="11" i2="1"><s1>FORSYTH (Cecily)</s1></fA11><fA11 i1="12" i2="1"><s1>DECAUDIN (Didier)</s1></fA11><fA11 i1="13" i2="1"><s1>FABIANI (Bettina)</s1></fA11><fA11 i1="14" i2="1"><s1>GABARRE (Jean)</s1></fA11><fA11 i1="15" i2="1"><s1>SALLES (Bruno)</s1></fA11><fA11 i1="16" i2="1"><s1>DEN NESTE (Eric Van)</s1></fA11><fA11 i1="17" i2="1"><s1>CANIONI (Danielle)</s1></fA11><fA11 i1="18" i2="1"><s1>GARIN (Etienne)</s1></fA11><fA11 i1="19" i2="1"><s1>FULHAM (Michael)</s1></fA11><fA11 i1="20" i2="1"><s1>BORGHT (Thierry Vander)</s1></fA11><fA11 i1="21" i2="1"><s1>SALLES (Gilles)</s1></fA11><fA14 i1="01"><s1>Concord Hospital</s1><s3>INC</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ></fA14><fA14 i1="02"><s1>Royal Prince Alfred Hospital and Sydney Medical School, University of Sydney</s1><s2>Sydney</s2><s3>AUS</s3><sZ>19 aut.</sZ></fA14><fA14 i1="03"><s1>Peter MacCallum Cancer Center and University of Melbourne</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>4 aut.</sZ></fA14><fA14 i1="04"><s1>Wyong Hospital</s1><s2>Kanwal</s2><s3>AUS</s3><sZ>11 aut.</sZ></fA14><fA14 i1="05"><s1>Hospices Civils de Lyon, Groupe d'Etude des Lymphomes de l'Adulte, Recherche Clinique, Hôpital Lyon sud, Pierre-Benite</s1><s3>FRA</s3><sZ>2 aut.</sZ></fA14><fA14 i1="06"><s1>Centre Hospitalier Universitaire (CHU) de Rennes, L'Institut National de la Sante et de la Recherche Médicale (INSERM) U917, Universite de Rennes</s1><s3>FRA</s3><sZ>3 aut.</sZ></fA14><fA14 i1="07"><s1>CHU de Rennes</s1><s2>Rennes</s2><s3>FRA</s3><sZ>18 aut.</sZ></fA14><fA14 i1="08"><s1>CHU de Tours</s1><s2>Tours</s2><s3>FRA</s3><sZ>8 aut.</sZ></fA14><fA14 i1="09"><s1>Centre Henri Becquerel, INSERM U918, Universite de Rouen</s1><s2>Rouen</s2><s3>FRA</s3><sZ>9 aut.</sZ></fA14><fA14 i1="10"><s1>Institut Curie</s1><s3>FRA</s3><sZ>12 aut.</sZ></fA14><fA14 i1="11"><s1>Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine</s1><s3>FRA</s3><sZ>13 aut.</sZ></fA14><fA14 i1="12"><s1>Hôpital de la Pitie Salpetriere</s1><s3>FRA</s3><sZ>14 aut.</sZ></fA14><fA14 i1="13"><s1>Hôpital Necker</s1><s2>Paris</s2><s3>FRA</s3><sZ>17 aut.</sZ></fA14><fA14 i1="14"><s1>Centre Hospitalier</s1><s2>Chalons-Saône</s2><s3>FRA</s3><sZ>15 aut.</sZ></fA14><fA14 i1="15"><s1>Hospices Civils de Lyon, Universite Lyon1</s1><s3>FRA</s3><sZ>21 aut.</sZ></fA14><fA14 i1="16"><s1>Universite Catholique de Louvain (UCL), Mont-Godinne Medical Center</s1><s2>Yvoir</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>20 aut.</sZ></fA14><fA14 i1="17"><s1>UCL Saint-Luc</s1><s2>Brussels</s2><s3>BEL</s3><sZ>16 aut.</sZ></fA14><fA14 i1="18"><s1>University Hospital Brno</s1><s2>Brno</s2><s3>CZE</s3><sZ>6 aut.</sZ></fA14><fA14 i1="19"><s1>Rabin Medical Center</s1><s2>Petah-Tikva</s2><s3>ISR</s3><sZ>7 aut.</sZ></fA14><fA14 i1="20"><s1>Tel Aviv University</s1><s2>Tel Aviv</s2><s3>ISR</s3><sZ>7 aut.</sZ></fA14><fA20><s1>3194-3200</s1></fA20><fA21><s1>2011</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20094</s2><s5>354000191138370140</s5></fA43><fA44><s0>0000</s0><s1>© 2011 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>29 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>11-0380678</s0></fA47><fA60><s1>P</s1><s3>C</s3></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Journal of clinical oncology</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Purpose The utility of [<sup>18</sup>F]fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT) in assessing response at the end of induction therapy is well documented in Hodgkin's and diffuse large B-cell lymphomas, but its role in follicular lymphoma (FL) remains undetermined. We investigated the prognostic significance of PET-CT performed after first-line therapy in patients with FL treated in the prospective Primary Rituximab and Maintenance (PRIMA) study. Patients and Methods Results of PET-CT scans performed after induction immunochemotherapy were recorded retrospectively. Patients went on to either observation or rituximab maintenance per protocol independent of the PET-CT result. Patient characteristics and outcomes were then evaluated. Results Of 122 PET-CT scans performed at the end of the induction immunochemotherapy, 32 (26%) were reported as positive by the local investigator. Initial demographic or disease characteristics did not differ between PET-CT-positive (PET-positive) and PET-CT-negative (PET-negative) patients. PET status correlated with conventional response criteria (P<.001). Patients remaining PET positive had a significantly (P< .001) inferior progression-free survival at 42 months of 32.9% (95% CI, 17.2% to 49.5%) compared with 70.7% (95% CI, 59.3% to 79.4%) in those who became PET negative. PET status, but not conventional response (complete response or complete response unconfirmed v partial response) according to IWC 1999, was an independent predictive factor for lymphoma progression. The risk of death was also increased in PET-positive patients (hazard ratio 7.0; P = .0011). Conclusion [<sup>18</sup>F]FDG PET-CT status at the end of immunochemotherapy induction in patients with FL is strongly predictive of outcome and should be considered a meaningful clinical end point in future studies.</s0></fC01><fC02 i1="01" i2="X"><s0>002B04</s0></fC02><fC02 i1="02" i2="X"><s0>002B19B</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Tomoscintigraphie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Emission tomography</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Tomocentelleografía</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Tomographie par émission de positons</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Positron emission tomography</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Tomografía emisión positrones</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Traitement induction</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Induction treatment</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Tratamiento inductivo</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Tomodensitométrie</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Computerized axial tomography</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Tomodensitometría</s0><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Homme</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Human</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Hombre</s0><s5>05</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Pronostic</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Prognosis</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Pronóstico</s0><s5>06</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Lymphome folliculaire</s0><s5>07</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Follicular lymphoma</s0><s5>07</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Linfoma folicular</s0><s5>07</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Essai clinique</s0><s5>08</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Clinical trial</s0><s5>08</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Ensayo clínico</s0><s5>08</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Cancérologie</s0><s5>09</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Cancerology</s0><s5>09</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Cancerología</s0><s5>09</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>Hémopathie maligne lymphoïde</s0><s4>CD</s4><s5>96</s5></fC03><fC03 i1="10" i2="X" l="ENG"><s0>Lymphoid neoplasm</s0><s4>CD</s4><s5>96</s5></fC03><fC03 i1="11" i2="X" l="FRE"><s0>Hémopathie lymphoïde B</s0><s4>CD</s4><s5>97</s5></fC03><fC03 i1="11" i2="X" l="ENG"><s0>B cell neoplasm</s0><s4>CD</s4><s5>97</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Exploration radioisotopique</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Radionuclide study</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Exploración radioisotópica</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Imagerie médicale</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Medical imagery</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Imaginería médica</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Radiodiagnostic</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Radiodiagnosis</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Radiodiagnóstico</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Hémopathie maligne</s0><s2>NM</s2><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Malignant hemopathy</s0><s2>NM</s2><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Hemopatía maligna</s0><s2>NM</s2><s5>40</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Cancer</s0><s2>NM</s2></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Cancer</s0><s2>NM</s2></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Cáncer</s0><s2>NM</s2></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Lymphome non hodgkinien</s0><s5>41</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Non Hodgkin lymphoma</s0><s5>41</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Linfoma no Hodgkin</s0><s5>41</s5></fC07><fC07 i1="07" i2="X" l="FRE"><s0>Syndrome lymphoprolifératif</s0><s2>NM</s2><s5>42</s5></fC07><fC07 i1="07" i2="X" l="ENG"><s0>Lymphoproliferative syndrome</s0><s2>NM</s2><s5>42</s5></fC07><fC07 i1="07" i2="X" l="SPA"><s0>Linfoproliferativo síndrome</s0><s2>NM</s2><s5>42</s5></fC07><fN21><s1>262</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist></record>Pour manipuler ce document sous Unix (Dilib)
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