Serveur d'exploration sur les relations entre la France et l'Australie

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Maximizing efficiency and cost-effectiveness of Type 2 diabetes screening: the AusDiab study

Identifieur interne : 004017 ( PascalFrancis/Curation ); précédent : 004016; suivant : 004018

Maximizing efficiency and cost-effectiveness of Type 2 diabetes screening: the AusDiab study

Auteurs : L. Chen [Australie] ; D. J. Magliano [Australie] ; B. Balkau [Australie, France] ; R. Wolfe [Australie] ; L. Brown [Australie] ; A. M. Tonkin [Australie] ; P. Z. Zimmet [Australie] ; J. E. Shaw [Australie]

Source :

RBID : Pascal:11-0155765

Descripteurs français

English descriptors

Abstract

Aims To evaluate how to most efficiently screen populations to detect people at high risk of incident Type 2 diabetes and those with prevalent, but undiagnosed, Type 2 diabetes. Methods Data from 5814 adults in the Australian Diabetes, Obesity and Lifestyle study were used to examine four different types of screening strategies. The strategies incorporated various combinations of cut-points of fasting plasma glucose, the non- invasive Australian Type 2 Diabetes Risk Assessment Tool (AUSDRISK1) and a modified version of the tool incorporating fasting plasma glucose (AUSDRISK2). Sensitivity, specificity, positive predictive value, screening costs per case of incident or prevalent undiagnosed diabetes identified and intervention costs per case of diabetes prevented or reverted were compared. Results Of the four strategies that maximized sensitivity and specificity, use of the non-invasive AUSDRISK1, followed by AUSDRISK2 in those found to be at increased risk on AUSDRISK1, had the highest sensitivity (80.3%; 95% confidence interval 76.6-84.1 %), specificity (78.1 %; 95% confidence interval 76.9-79.2%) and positive predictive value (22.3%; 95% confidence interval 20.2-24.4%) for identifying people with either prevalent undiagnosed diabetes or future incident diabetes. It required the fewest people (24.1 %; 95% confidence interval 23.0-25.2%) to enter lifestyle modification programmes, and also had the lowest intervention costs and combined costs of running screening and intervention programmes per case of diabetes prevented or reverted. Conclusions Using a self-assessed diabetes risk score as an initial screening step, followed by a second risk score incorporating fasting plasma glucose, would maximize efficiency of identifying people with undiagnosed Type 2 diabetes and those at high risk of future diabetes.
pA  
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A02 01      @0 DIMEEV
A03   1    @0 Diabetic med.
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A08 01  1  ENG  @1 Maximizing efficiency and cost-effectiveness of Type 2 diabetes screening: the AusDiab study
A11 01  1    @1 CHEN (L.)
A11 02  1    @1 MAGLIANO (D. J.)
A11 03  1    @1 BALKAU (B.)
A11 04  1    @1 WOLFE (R.)
A11 05  1    @1 BROWN (L.)
A11 06  1    @1 TONKIN (A. M.)
A11 07  1    @1 ZIMMET (P. Z.)
A11 08  1    @1 SHAW (J. E.)
A14 01      @1 Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University @2 Melbourne, Victoria @3 AUS @Z 1 aut. @Z 2 aut. @Z 4 aut. @Z 6 aut.
A14 02      @1 Baker IDI Heart and Diabetes Institute @2 Melbourne, Vic @3 AUS @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 7 aut. @Z 8 aut.
A14 03      @1 Epidemiology of diabetes, obesity and chronic kidney disease over the lifecourse, CESP Centre for Research in Epidemiology and Public Health, U1018 Inserm @2 Villejuif @3 FRA @Z 3 aut.
A14 04      @1 University Paris-Sud 11, UMRS 1018 @2 Villejuif @3 FRA @Z 3 aut.
A14 05      @1 National Centre for Social and Economic Modelling, University of Canberra @2 Canberra, ACT @3 AUS @Z 5 aut.
A20       @1 414-423
A21       @1 2011
A23 01      @0 ENG
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A60       @1 P
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A64 01  1    @0 Diabetic medicine
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C01 01    ENG  @0 Aims To evaluate how to most efficiently screen populations to detect people at high risk of incident Type 2 diabetes and those with prevalent, but undiagnosed, Type 2 diabetes. Methods Data from 5814 adults in the Australian Diabetes, Obesity and Lifestyle study were used to examine four different types of screening strategies. The strategies incorporated various combinations of cut-points of fasting plasma glucose, the non- invasive Australian Type 2 Diabetes Risk Assessment Tool (AUSDRISK1) and a modified version of the tool incorporating fasting plasma glucose (AUSDRISK2). Sensitivity, specificity, positive predictive value, screening costs per case of incident or prevalent undiagnosed diabetes identified and intervention costs per case of diabetes prevented or reverted were compared. Results Of the four strategies that maximized sensitivity and specificity, use of the non-invasive AUSDRISK1, followed by AUSDRISK2 in those found to be at increased risk on AUSDRISK1, had the highest sensitivity (80.3%; 95% confidence interval 76.6-84.1 %), specificity (78.1 %; 95% confidence interval 76.9-79.2%) and positive predictive value (22.3%; 95% confidence interval 20.2-24.4%) for identifying people with either prevalent undiagnosed diabetes or future incident diabetes. It required the fewest people (24.1 %; 95% confidence interval 23.0-25.2%) to enter lifestyle modification programmes, and also had the lowest intervention costs and combined costs of running screening and intervention programmes per case of diabetes prevented or reverted. Conclusions Using a self-assessed diabetes risk score as an initial screening step, followed by a second risk score incorporating fasting plasma glucose, would maximize efficiency of identifying people with undiagnosed Type 2 diabetes and those at high risk of future diabetes.
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Pascal:11-0155765

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<title level="j" type="main">Diabetic medicine</title>
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<title level="j" type="main">Diabetic medicine</title>
<title level="j" type="abbreviated">Diabetic med.</title>
<idno type="ISSN">0742-3071</idno>
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<term>Australia</term>
<term>Cost efficiency analysis</term>
<term>Costs</term>
<term>Economic aspect</term>
<term>Efficiency</term>
<term>Endocrinology</term>
<term>Epidemiology</term>
<term>Health economy</term>
<term>Life style</term>
<term>Medical screening</term>
<term>Nutritional status</term>
<term>Obesity</term>
<term>Prediction</term>
<term>Predictive factor</term>
<term>Public health</term>
<term>Risk</term>
<term>Risk factor</term>
<term>Strategy</term>
<term>Type 2 diabetes</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr">
<term>Diabète de type 2</term>
<term>Efficacité</term>
<term>Analyse coût efficacité</term>
<term>Obésité</term>
<term>Economie santé</term>
<term>Dépistage</term>
<term>Australie</term>
<term>Epidémiologie</term>
<term>Mode de vie</term>
<term>Santé publique</term>
<term>Coût</term>
<term>Aspect économique</term>
<term>Prédiction</term>
<term>Facteur prédictif</term>
<term>Facteur risque</term>
<term>Risque</term>
<term>Stratégie</term>
<term>Endocrinologie</term>
<term>Etat nutritionnel</term>
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<term>Australie</term>
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<term>Santé publique</term>
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<div type="abstract" xml:lang="en">Aims To evaluate how to most efficiently screen populations to detect people at high risk of incident Type 2 diabetes and those with prevalent, but undiagnosed, Type 2 diabetes. Methods Data from 5814 adults in the Australian Diabetes, Obesity and Lifestyle study were used to examine four different types of screening strategies. The strategies incorporated various combinations of cut-points of fasting plasma glucose, the non- invasive Australian Type 2 Diabetes Risk Assessment Tool (AUSDRISK1) and a modified version of the tool incorporating fasting plasma glucose (AUSDRISK2). Sensitivity, specificity, positive predictive value, screening costs per case of incident or prevalent undiagnosed diabetes identified and intervention costs per case of diabetes prevented or reverted were compared. Results Of the four strategies that maximized sensitivity and specificity, use of the non-invasive AUSDRISK1, followed by AUSDRISK2 in those found to be at increased risk on AUSDRISK1, had the highest sensitivity (80.3%; 95% confidence interval 76.6-84.1 %), specificity (78.1 %; 95% confidence interval 76.9-79.2%) and positive predictive value (22.3%; 95% confidence interval 20.2-24.4%) for identifying people with either prevalent undiagnosed diabetes or future incident diabetes. It required the fewest people (24.1 %; 95% confidence interval 23.0-25.2%) to enter lifestyle modification programmes, and also had the lowest intervention costs and combined costs of running screening and intervention programmes per case of diabetes prevented or reverted. Conclusions Using a self-assessed diabetes risk score as an initial screening step, followed by a second risk score incorporating fasting plasma glucose, would maximize efficiency of identifying people with undiagnosed Type 2 diabetes and those at high risk of future diabetes.</div>
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<s0>Aims To evaluate how to most efficiently screen populations to detect people at high risk of incident Type 2 diabetes and those with prevalent, but undiagnosed, Type 2 diabetes. Methods Data from 5814 adults in the Australian Diabetes, Obesity and Lifestyle study were used to examine four different types of screening strategies. The strategies incorporated various combinations of cut-points of fasting plasma glucose, the non- invasive Australian Type 2 Diabetes Risk Assessment Tool (AUSDRISK1) and a modified version of the tool incorporating fasting plasma glucose (AUSDRISK2). Sensitivity, specificity, positive predictive value, screening costs per case of incident or prevalent undiagnosed diabetes identified and intervention costs per case of diabetes prevented or reverted were compared. Results Of the four strategies that maximized sensitivity and specificity, use of the non-invasive AUSDRISK1, followed by AUSDRISK2 in those found to be at increased risk on AUSDRISK1, had the highest sensitivity (80.3%; 95% confidence interval 76.6-84.1 %), specificity (78.1 %; 95% confidence interval 76.9-79.2%) and positive predictive value (22.3%; 95% confidence interval 20.2-24.4%) for identifying people with either prevalent undiagnosed diabetes or future incident diabetes. It required the fewest people (24.1 %; 95% confidence interval 23.0-25.2%) to enter lifestyle modification programmes, and also had the lowest intervention costs and combined costs of running screening and intervention programmes per case of diabetes prevented or reverted. Conclusions Using a self-assessed diabetes risk score as an initial screening step, followed by a second risk score incorporating fasting plasma glucose, would maximize efficiency of identifying people with undiagnosed Type 2 diabetes and those at high risk of future diabetes.</s0>
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