AustralieFrV1, PascalFrancis, Curation, bibRecord, 003764

Prospects for epigenetic research within cohort studies of psychological disorder: A pilot investigation of a peripheral cell marker of epigenetic risk for depression

Identifieur interne : 003764 ( PascalFrancis/Curation ); précédent : 003763; suivant : 003765

Prospects for epigenetic research within cohort studies of psychological disorder: A pilot investigation of a peripheral cell marker of epigenetic risk for depression

Auteurs : C. A. Olsson [Australie] ; D. L. Foley [Australie] ; M. Parkinson-Bates [Australie] ; G. Byrnes [France] ; M. Mckenzie [Australie] ; G. C. Patton [Australie] ; R. Morley [Australie] ; R. J. L. Anney [Irlande (pays)] ; J. M. Craig [Australie] ; R. Saffery [Australie]

Source :

Biological psychology [ 0301-0511 ] ; 2010.

RBID : Pascal:10-0133631

Descripteurs français

Pascal (Inist)
- Epigenèse, Etude cohorte, Psychopathologie, Déterminisme génétique, Facteur risque, Etat dépressif, DNA, Méthylation, Polymorphisme, Transporteur de la sérotonine, Adolescent, Gène 5HTT.

English descriptors

KwdEn :
- Adolescent, Cohort study, DNA, Depression, Epigenesis, Genetic determinism, Methylation, Polymorphism, Psychopathology, Risk factor, Serotonin transporter.

Abstract

Cohort studies have considerable prima facie value for investigating epigenetic processes in psychological disorder; however, the future prospects for such studies will depend on valid peripheral markers. The purpose of this pilot study was to investigate association between buccal cell methylation and risk for depression. Epigenotyping was limited to promoter methylation of the serotonin transporter gene (5HTT). A transcription limiting VNTR in the 5HTT promoter (5HTTLPR) was also genotyped. A nested sample of 25 depressed and 125 non-depressed adolescents was drawn from an established longitudinal study of adolescent health. There was no association between depressive symptoms and either buccal cell 5HTT methylation or 5HTTLPR. However, depressive symptoms were more common among those with elevated buccal cell 5HTT methylation who carried 5HTTLPR short-allele (OR 4.9, CI 1.9-13, p = 0.001). Both complete and partial (as little as 10%) methylation of a 5HTT reporter gene in an expressing cell line reduced 5HTT activity. Replication is needed.

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Cohort study</term>
<term>DNA</term>
<term>Depression</term>
<term>Epigenesis</term>
<term>Genetic determinism</term>
<term>Methylation</term>
<term>Polymorphism</term>
<term>Psychopathology</term>
<term>Risk factor</term>
<term>Serotonin transporter</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Epigenèse</term>
<term>Etude cohorte</term>
<term>Psychopathologie</term>
<term>Déterminisme génétique</term>
<term>Facteur risque</term>
<term>Etat dépressif</term>
<term>DNA</term>
<term>Méthylation</term>
<term>Polymorphisme</term>
<term>Transporteur de la sérotonine</term>
<term>Adolescent</term>
<term>Gène 5HTT</term>
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<front><div type="abstract" xml:lang="en">Cohort studies have considerable prima facie value for investigating epigenetic processes in psychological disorder; however, the future prospects for such studies will depend on valid peripheral markers. The purpose of this pilot study was to investigate association between buccal cell methylation and risk for depression. Epigenotyping was limited to promoter methylation of the serotonin transporter gene (5HTT). A transcription limiting VNTR in the 5HTT promoter (5HTTLPR) was also genotyped. A nested sample of 25 depressed and 125 non-depressed adolescents was drawn from an established longitudinal study of adolescent health. There was no association between depressive symptoms and either buccal cell 5HTT methylation or 5HTTLPR. However, depressive symptoms were more common among those with elevated buccal cell 5HTT methylation who carried 5HTTLPR short-allele (OR 4.9, CI 1.9-13, p = 0.001). Both complete and partial (as little as 10%) methylation of a 5HTT reporter gene in an expressing cell line reduced 5HTT activity. Replication is needed.</div>
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<fA02 i1="01"><s0>BLPYAX</s0>
</fA02>
<fA03 i2="1"><s0>Biol. psychol.</s0>
</fA03>
<fA05><s2>83</s2>
</fA05>
<fA06><s2>2</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Prospects for epigenetic research within cohort studies of psychological disorder: A pilot investigation of a peripheral cell marker of epigenetic risk for depression</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>OLSSON (C. A.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>FOLEY (D. L.)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>PARKINSON-BATES (M.)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>BYRNES (G.)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>MCKENZIE (M.)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>PATTON (G. C.)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>MORLEY (R.)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>ANNEY (R. J. L.)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>CRAIG (J. M.)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>SAFFERY (R.)</s1>
</fA11>
<fA14 i1="01"><s1>Murdoch Childrens Research Institute</s1>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Psychological Sciences, University of Melbourne</s1>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Paediatrics, University of Melbourne</s1>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Orygen Youth Health Research Centre, University of Melbourne</s1>
<s3>AUS</s3>
<sZ>2 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>International Agency for Research on Cancer</s1>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Department of Psychiatry, Trinity College Dublin</s1>
<s3>IRL</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA20><s1>159-165</s1>
</fA20>
<fA21><s1>2010</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>16230</s2>
<s5>354000180990370120</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2010 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>1/2 p.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>10-0133631</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Biological psychology</s0>
</fA64>
<fA66 i1="01"><s0>IRL</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Cohort studies have considerable prima facie value for investigating epigenetic processes in psychological disorder; however, the future prospects for such studies will depend on valid peripheral markers. The purpose of this pilot study was to investigate association between buccal cell methylation and risk for depression. Epigenotyping was limited to promoter methylation of the serotonin transporter gene (5HTT). A transcription limiting VNTR in the 5HTT promoter (5HTTLPR) was also genotyped. A nested sample of 25 depressed and 125 non-depressed adolescents was drawn from an established longitudinal study of adolescent health. There was no association between depressive symptoms and either buccal cell 5HTT methylation or 5HTTLPR. However, depressive symptoms were more common among those with elevated buccal cell 5HTT methylation who carried 5HTTLPR short-allele (OR 4.9, CI 1.9-13, p = 0.001). Both complete and partial (as little as 10%) methylation of a 5HTT reporter gene in an expressing cell line reduced 5HTT activity. Replication is needed.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002A26C</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B18C07A</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Epigenèse</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Epigenesis</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Epigénesis</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Etude cohorte</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Cohort study</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Estudio cohorte</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Psychopathologie</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Psychopathology</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Psicopatología</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Déterminisme génétique</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Genetic determinism</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Determinismo genético</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Facteur risque</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Risk factor</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Factor riesgo</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Etat dépressif</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Depression</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Estado depresivo</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>DNA</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>DNA</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>DNA</s0>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Méthylation</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Methylation</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Metilación</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Polymorphisme</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Polymorphism</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Polimorfismo</s0>
<s5>09</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Transporteur de la sérotonine</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Serotonin transporter</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Transportador de la serotonina</s0>
<s5>10</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Adolescent</s0>
<s5>19</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Adolescent</s0>
<s5>19</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Adolescente</s0>
<s5>19</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Gène 5HTT</s0>
<s4>INC</s4>
<s5>86</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Homme</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Human</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Hombre</s0>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Trouble de l'humeur</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Mood disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Trastorno humor</s0>
<s5>37</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Génétique</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Genetics</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Genética</s0>
<s5>38</s5>
</fC07>
<fN21><s1>088</s1>
</fN21>
</pA>
</standard>
</inist>
</record>

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Prospects for epigenetic research within cohort studies of psychological disorder: A pilot investigation of a peripheral cell marker of epigenetic risk for depression

Prospects for epigenetic research within cohort studies of psychological disorder: A pilot investigation of a peripheral cell marker of epigenetic risk for depression

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