AustralieFrV1, PascalFrancis, Curation, bibRecord, 003424

A cell-autonomous role for WT1 in regulating Sry in vivo

Identifieur interne : 003424 ( PascalFrancis/Curation ); précédent : 003423; suivant : 003425

A cell-autonomous role for WT1 in regulating Sry in vivo

Auteurs : Stephen T. Bradford [Australie] ; Dagmar Wilhelm [Australie] ; Roberto Bandiera [France] ; Valerie Vidal [France] ; Andreas Schedl [France] ; Peter Koopman [Australie]

Source :

Human molecular genetics : (Print) [ 0964-6906 ] ; 2009.

RBID : Pascal:09-0381710

Descripteurs français

Pascal (Inist)
- In vivo, Génétique.
Wicri :
- topic : Génétique.

English descriptors

KwdEn :
- Genetics, In vivo.

Abstract

Human patients with Frasier syndrome express reduced levels of the +KTS isoforms of the developmental regulator WT1 and exhibit complete XY gonadal dysgenesis and male-to-female sex reversal. Mice with a targeted mutation that blocks production of these isoforms show a reduction in Sry mRNA in the gonad, but the molecular and cellular basis of this reduction has not been established. Using immunofluorescence analysis, we found a significantly lower level of SRY protein per cell in XY Wt1(+KTS)-null mouse gonads. We also found a reduced number of SRY-expressing cells, correlating with a decrease in cell proliferation at and near the coelomic epithelium at 11.5 dpc. No reduction in somatic cell numbers was seen in XX Wt1(+ KTS)-null gonads, indicating that the effect of WT1 on cell proliferation is mediated by Sry. Sertoli cell differentiation was blocked in XY Wt1(+KTS)-null mouse gonads, as indicated by the loss of SOX9 and Fgf9 expression, but the addition of recombinant FGF9 to ex vivo gonad cultures rescued the mutant phenotype, as indicated by the induction of the Sertoli-cell specific marker anti-Mullerian hormone. Our data suggest that WT1 (+KTS) is involved in the cell-autonomous regulation of Sry expression, which in turn influences cell proliferation and Sertoli cell differentiation via FGF9. Thus, sex reversal in Wtl(+KTS)-null mice and Frasier syndrome patients results from a failure of Sertoli cells both to fully differentiate and to reach sufficient numbers to direct testis development.

A01	`01`	`1`		`@0 0964-6906`
A03		`1`		`@0 Hum. mol. genet. : (Print)`
A05				`@2 18`
A06				`@2 18`
A08	`01`	`1`	`ENG`	`@1 A cell-autonomous role for WT1 in regulating Sry in vivo`
A11	`01`	`1`		`@1 BRADFORD (Stephen T.)`
A11	`02`	`1`		`@1 WILHELM (Dagmar)`
A11	`03`	`1`		`@1 BANDIERA (Roberto)`
A11	`04`	`1`		`@1 VIDAL (Valerie)`
A11	`05`	`1`		`@1 SCHEDL (Andreas)`
A11	`06`	`1`		`@1 KOOPMAN (Peter)`
A14	`01`			`@1 Division of Molecular Genetics and Development, Institute for Molecular Biosciences, The University of Queensland @2 Brisbane QLD 4072 @3 AUS @Z 1 aut. @Z 2 aut. @Z 6 aut.`
A14	`02`			`@1 INSERM, U636 @2 06108 Nice @3 FRA @Z 3 aut. @Z 4 aut. @Z 5 aut.`
A14	`03`			`@1 Université de Nice-Sophia Antipolis @2 06108 Nice @3 FRA @Z 3 aut. @Z 4 aut. @Z 5 aut.`
A20				`@1 3429-3438`
A21				`@1 2009`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 22540 @5 354000171834690080`
A44				`@0 0000 @1 © 2009 INIST-CNRS. All rights reserved.`
A45				`@0 38 ref.`
A47	`01`	`1`		`@0 09-0381710`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Human molecular genetics : (Print)`
A66	`01`			`@0 GBR`
C01	`01`		`ENG`	@0 Human patients with Frasier syndrome express reduced levels of the +KTS isoforms of the developmental regulator WT1 and exhibit complete XY gonadal dysgenesis and male-to-female sex reversal. Mice with a targeted mutation that blocks production of these isoforms show a reduction in Sry mRNA in the gonad, but the molecular and cellular basis of this reduction has not been established. Using immunofluorescence analysis, we found a significantly lower level of SRY protein per cell in XY Wt1(+KTS)-null mouse gonads. We also found a reduced number of SRY-expressing cells, correlating with a decrease in cell proliferation at and near the coelomic epithelium at 11.5 dpc. No reduction in somatic cell numbers was seen in XX Wt1(+ KTS)-null gonads, indicating that the effect of WT1 on cell proliferation is mediated by Sry. Sertoli cell differentiation was blocked in XY Wt1(+KTS)-null mouse gonads, as indicated by the loss of SOX9 and Fgf9 expression, but the addition of recombinant FGF9 to ex vivo gonad cultures rescued the mutant phenotype, as indicated by the induction of the Sertoli-cell specific marker anti-Mullerian hormone. Our data suggest that WT1 (+KTS) is involved in the cell-autonomous regulation of Sry expression, which in turn influences cell proliferation and Sertoli cell differentiation via FGF9. Thus, sex reversal in Wtl(+KTS)-null mice and Frasier syndrome patients results from a failure of Sertoli cells both to fully differentiate and to reach sufficient numbers to direct testis development.
C02	`01`	`X`		`@0 002A04`
C02	`02`	`X`		`@0 002A07`
C03	`01`	`X`	`FRE`	`@0 In vivo @5 01`
C03	`01`	`X`	`ENG`	`@0 In vivo @5 01`
C03	`01`	`X`	`SPA`	`@0 In vivo @5 01`
C03	`02`	`X`	`FRE`	`@0 Génétique @5 02`
C03	`02`	`X`	`ENG`	`@0 Genetics @5 02`
C03	`02`	`X`	`SPA`	`@0 Genética @5 02`
N21				`@1 278`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002B99

Links to Exploration step

Pascal:09-0381710

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">A cell-autonomous role for WT1 in regulating Sry in vivo</title>
<author><name sortKey="Bradford, Stephen T" sort="Bradford, Stephen T" uniqKey="Bradford S" first="Stephen T." last="Bradford">Stephen T. Bradford</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Molecular Genetics and Development, Institute for Molecular Biosciences, The University of Queensland</s1>
<s2>Brisbane QLD 4072</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Australie</country>
</affiliation>
</author>
<author><name sortKey="Wilhelm, Dagmar" sort="Wilhelm, Dagmar" uniqKey="Wilhelm D" first="Dagmar" last="Wilhelm">Dagmar Wilhelm</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Molecular Genetics and Development, Institute for Molecular Biosciences, The University of Queensland</s1>
<s2>Brisbane QLD 4072</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Australie</country>
</affiliation>
</author>
<author><name sortKey="Bandiera, Roberto" sort="Bandiera, Roberto" uniqKey="Bandiera R" first="Roberto" last="Bandiera">Roberto Bandiera</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U636</s1>
<s2>06108 Nice</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Université de Nice-Sophia Antipolis</s1>
<s2>06108 Nice</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Vidal, Valerie" sort="Vidal, Valerie" uniqKey="Vidal V" first="Valerie" last="Vidal">Valerie Vidal</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U636</s1>
<s2>06108 Nice</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Université de Nice-Sophia Antipolis</s1>
<s2>06108 Nice</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Schedl, Andreas" sort="Schedl, Andreas" uniqKey="Schedl A" first="Andreas" last="Schedl">Andreas Schedl</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U636</s1>
<s2>06108 Nice</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Université de Nice-Sophia Antipolis</s1>
<s2>06108 Nice</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Koopman, Peter" sort="Koopman, Peter" uniqKey="Koopman P" first="Peter" last="Koopman">Peter Koopman</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Molecular Genetics and Development, Institute for Molecular Biosciences, The University of Queensland</s1>
<s2>Brisbane QLD 4072</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Australie</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">09-0381710</idno>
<date when="2009">2009</date>
<idno type="stanalyst">PASCAL 09-0381710 INIST</idno>
<idno type="RBID">Pascal:09-0381710</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">002B99</idno>
<idno type="wicri:Area/PascalFrancis/Curation">003424</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">A cell-autonomous role for WT1 in regulating Sry in vivo</title>
<author><name sortKey="Bradford, Stephen T" sort="Bradford, Stephen T" uniqKey="Bradford S" first="Stephen T." last="Bradford">Stephen T. Bradford</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Molecular Genetics and Development, Institute for Molecular Biosciences, The University of Queensland</s1>
<s2>Brisbane QLD 4072</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Australie</country>
</affiliation>
</author>
<author><name sortKey="Wilhelm, Dagmar" sort="Wilhelm, Dagmar" uniqKey="Wilhelm D" first="Dagmar" last="Wilhelm">Dagmar Wilhelm</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Molecular Genetics and Development, Institute for Molecular Biosciences, The University of Queensland</s1>
<s2>Brisbane QLD 4072</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Australie</country>
</affiliation>
</author>
<author><name sortKey="Bandiera, Roberto" sort="Bandiera, Roberto" uniqKey="Bandiera R" first="Roberto" last="Bandiera">Roberto Bandiera</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U636</s1>
<s2>06108 Nice</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Université de Nice-Sophia Antipolis</s1>
<s2>06108 Nice</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Vidal, Valerie" sort="Vidal, Valerie" uniqKey="Vidal V" first="Valerie" last="Vidal">Valerie Vidal</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U636</s1>
<s2>06108 Nice</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Université de Nice-Sophia Antipolis</s1>
<s2>06108 Nice</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Schedl, Andreas" sort="Schedl, Andreas" uniqKey="Schedl A" first="Andreas" last="Schedl">Andreas Schedl</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U636</s1>
<s2>06108 Nice</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Université de Nice-Sophia Antipolis</s1>
<s2>06108 Nice</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Koopman, Peter" sort="Koopman, Peter" uniqKey="Koopman P" first="Peter" last="Koopman">Peter Koopman</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Molecular Genetics and Development, Institute for Molecular Biosciences, The University of Queensland</s1>
<s2>Brisbane QLD 4072</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Australie</country>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Human molecular genetics : (Print)</title>
<title level="j" type="abbreviated">Hum. mol. genet. : (Print)</title>
<idno type="ISSN">0964-6906</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Human molecular genetics : (Print)</title>
<title level="j" type="abbreviated">Hum. mol. genet. : (Print)</title>
<idno type="ISSN">0964-6906</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Genetics</term>
<term>In vivo</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>In vivo</term>
<term>Génétique</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Génétique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Human patients with Frasier syndrome express reduced levels of the +KTS isoforms of the developmental regulator WT1 and exhibit complete XY gonadal dysgenesis and male-to-female sex reversal. Mice with a targeted mutation that blocks production of these isoforms show a reduction in Sry mRNA in the gonad, but the molecular and cellular basis of this reduction has not been established. Using immunofluorescence analysis, we found a significantly lower level of SRY protein per cell in XY Wt1(+KTS)-null mouse gonads. We also found a reduced number of SRY-expressing cells, correlating with a decrease in cell proliferation at and near the coelomic epithelium at 11.5 dpc. No reduction in somatic cell numbers was seen in XX Wt1(+ KTS)-null gonads, indicating that the effect of WT1 on cell proliferation is mediated by Sry. Sertoli cell differentiation was blocked in XY Wt1(+KTS)-null mouse gonads, as indicated by the loss of SOX9 and Fgf9 expression, but the addition of recombinant FGF9 to ex vivo gonad cultures rescued the mutant phenotype, as indicated by the induction of the Sertoli-cell specific marker anti-Mullerian hormone. Our data suggest that WT1 (+KTS) is involved in the cell-autonomous regulation of Sry expression, which in turn influences cell proliferation and Sertoli cell differentiation via FGF9. Thus, sex reversal in Wtl(+KTS)-null mice and Frasier syndrome patients results from a failure of Sertoli cells both to fully differentiate and to reach sufficient numbers to direct testis development.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0964-6906</s0>
</fA01>
<fA03 i2="1"><s0>Hum. mol. genet. : (Print)</s0>
</fA03>
<fA05><s2>18</s2>
</fA05>
<fA06><s2>18</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>A cell-autonomous role for WT1 in regulating Sry in vivo</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>BRADFORD (Stephen T.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>WILHELM (Dagmar)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>BANDIERA (Roberto)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>VIDAL (Valerie)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>SCHEDL (Andreas)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>KOOPMAN (Peter)</s1>
</fA11>
<fA14 i1="01"><s1>Division of Molecular Genetics and Development, Institute for Molecular Biosciences, The University of Queensland</s1>
<s2>Brisbane QLD 4072</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>INSERM, U636</s1>
<s2>06108 Nice</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Université de Nice-Sophia Antipolis</s1>
<s2>06108 Nice</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</fA14>
<fA20><s1>3429-3438</s1>
</fA20>
<fA21><s1>2009</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>22540</s2>
<s5>354000171834690080</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2009 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>38 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>09-0381710</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Human molecular genetics : (Print)</s0>
</fA64>
<fA66 i1="01"><s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Human patients with Frasier syndrome express reduced levels of the +KTS isoforms of the developmental regulator WT1 and exhibit complete XY gonadal dysgenesis and male-to-female sex reversal. Mice with a targeted mutation that blocks production of these isoforms show a reduction in Sry mRNA in the gonad, but the molecular and cellular basis of this reduction has not been established. Using immunofluorescence analysis, we found a significantly lower level of SRY protein per cell in XY Wt1(+KTS)-null mouse gonads. We also found a reduced number of SRY-expressing cells, correlating with a decrease in cell proliferation at and near the coelomic epithelium at 11.5 dpc. No reduction in somatic cell numbers was seen in XX Wt1(+ KTS)-null gonads, indicating that the effect of WT1 on cell proliferation is mediated by Sry. Sertoli cell differentiation was blocked in XY Wt1(+KTS)-null mouse gonads, as indicated by the loss of SOX9 and Fgf9 expression, but the addition of recombinant FGF9 to ex vivo gonad cultures rescued the mutant phenotype, as indicated by the induction of the Sertoli-cell specific marker anti-Mullerian hormone. Our data suggest that WT1 (+KTS) is involved in the cell-autonomous regulation of Sry expression, which in turn influences cell proliferation and Sertoli cell differentiation via FGF9. Thus, sex reversal in Wtl(+KTS)-null mice and Frasier syndrome patients results from a failure of Sertoli cells both to fully differentiate and to reach sufficient numbers to direct testis development.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002A04</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002A07</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>In vivo</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>In vivo</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>In vivo</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Génétique</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Genetics</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Genética</s0>
<s5>02</s5>
</fC03>
<fN21><s1>278</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PascalFrancis/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003424 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Curation/biblio.hfd -nk 003424 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    PascalFrancis
   |étape=   Curation
   |type=    RBID
   |clé=     Pascal:09-0381710
   |texte=   A cell-autonomous role for WT1 in regulating Sry in vivo
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les relations entre la France et l'Australie

A cell-autonomous role for WT1 in regulating Sry in vivo

A cell-autonomous role for WT1 in regulating Sry in vivo

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri