AustralieFrV1, PascalFrancis, Curation, bibRecord, 003178

Does the 'gateway' matter? Associations between the order of drug use initiation and the development of drug dependence in the National Comorbidity Study Replication

Identifieur interne : 003178 ( PascalFrancis/Curation ); précédent : 003177; suivant : 003179

Does the 'gateway' matter? Associations between the order of drug use initiation and the development of drug dependence in the National Comorbidity Study Replication

Auteurs : L. Degenhardt [Australie] ; W. T. Chiu [États-Unis] ; K. Conway [États-Unis] ; L. Dierker [États-Unis] ; M. Glantz [États-Unis] ; A. Kalaydjian [États-Unis] ; K. Merikangas [États-Unis] ; N. Sampson [États-Unis] ; J. Swendsen [France] ; R. C. Kessler [États-Unis]

Source :

Psychological medicine : (Print) [ 0033-2917 ] ; 2009.

RBID : Pascal:09-0197650

Descripteurs français

Pascal (Inist)
- Facteur risque, Toxicomanie, Drogue illicite, Dépendance, Consommation, Tabac, Boisson alcoolisée, Cannabis, Santé publique, Santé mentale, Environnement social, Etats-Unis, Homme, Ordre apparition.
Wicri :
- topic : Toxicomanie, Consommation, Tabac, Boisson alcoolisée, Santé publique, Santé mentale, Homme.

English descriptors

KwdEn :
- Alcoholic beverage, Cannabis, Consumption, Dependence, Drug addiction, Human, Illicit drug, Mental health, Public health, Risk factor, Social environment, Tobacco, United States.

Abstract

Background. The 'gateway' pattern of drug initiation describes a normative sequence, beginning with alcohol and tobacco use, followed by cannabis, then other illicit drugs. Previous work has suggested that 'violations' of this sequence may be predictors of later problems but other determinants were not considered. We have examined the role of pre-existing mental disorders and sociodemographics in explaining the predictive effects of violations using data from the US National Comorbidity Survey Replication (NCS-R). Method. The NCS-R is a nationally representative face-to-face household survey of 9282 English-speaking respondents aged 18 years and older that used the World Health Organization (WHO) Composite International Diagnostic Interview (CIDI) to assess DSM-IV mental and substance disorders. Drug initiation was estimated using retrospective age-of-onset reports and 'violations' defined as inconsistent with the normative initiation order. Predictors of violations were examined using multivariable logistic regressions. Discrete-time survival analysis was used to see whether violations predicted progression to dependence. Results. Gateway violations were largely unrelated to later dependence risk, with the exception of small increases in risk of alcohol and other illicit drug dependence for those who initiated use of other illicit drugs before cannabis. Early-onset internalizing disorders were predictors of gateway violations, and both internalizing and externalizing disorders increased the risks of dependence among users of all drugs. Conclusions. Drug use initiation follows a strong normative pattern, deviations from which are not strongly predictive of later problems. By contrast, adolescents who have already developed mental health problems are at risk for deviations from the normative sequence of drug initiation and for the development of dependence.

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A11	`01`	`1`		`@1 DEGENHARDT (L.)`
A11	`02`	`1`		`@1 CHIU (W. T.)`
A11	`03`	`1`		`@1 CONWAY (K.)`
A11	`04`	`1`		`@1 DIERKER (L.)`
A11	`05`	`1`		`@1 GLANTZ (M.)`
A11	`06`	`1`		`@1 KALAYDJIAN (A.)`
A11	`07`	`1`		`@1 MERIKANGAS (K.)`
A11	`08`	`1`		`@1 SAMPSON (N.)`
A11	`09`	`1`		`@1 SWENDSEN (J.)`
A11	`10`	`1`		`@1 KESSLER (R. C.)`
A14	`01`			`@1 National Drug and Alcohol Research Centre, University of NSW @2 Sydney, NSW @3 AUS @Z 1 aut.`
A14	`02`			`@1 Department of Health Care Policy, Harvard Medical School @2 Boston, MA @3 USA @Z 2 aut. @Z 8 aut. @Z 10 aut.`
A14	`03`			`@1 Division of Epidemiology, Services and Prevention Research, National Institute on Drug Abuse, US National Institutes of Health @2 Bethesda, MD @3 USA @Z 3 aut. @Z 5 aut.`
A14	`04`			`@1 Department of Psychology, Wesleyan University @2 Middletown, CT @3 USA @Z 4 aut.`
A14	`05`			`@1 National Institute of Mental Health @2 Bethesda, MD @3 USA @Z 6 aut. @Z 7 aut.`
A14	`06`			`@1 Psychopathology Research Laboratory, University of Bordeaux @2 Bordeaux @3 FRA @Z 9 aut.`
A20				`@1 157-167`
A21				`@1 2009`
A23	`01`			`@0 ENG`
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A44				`@0 0000 @1 © 2009 INIST-CNRS. All rights reserved.`
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C01	`01`		`ENG`	@0 Background. The 'gateway' pattern of drug initiation describes a normative sequence, beginning with alcohol and tobacco use, followed by cannabis, then other illicit drugs. Previous work has suggested that 'violations' of this sequence may be predictors of later problems but other determinants were not considered. We have examined the role of pre-existing mental disorders and sociodemographics in explaining the predictive effects of violations using data from the US National Comorbidity Survey Replication (NCS-R). Method. The NCS-R is a nationally representative face-to-face household survey of 9282 English-speaking respondents aged 18 years and older that used the World Health Organization (WHO) Composite International Diagnostic Interview (CIDI) to assess DSM-IV mental and substance disorders. Drug initiation was estimated using retrospective age-of-onset reports and 'violations' defined as inconsistent with the normative initiation order. Predictors of violations were examined using multivariable logistic regressions. Discrete-time survival analysis was used to see whether violations predicted progression to dependence. Results. Gateway violations were largely unrelated to later dependence risk, with the exception of small increases in risk of alcohol and other illicit drug dependence for those who initiated use of other illicit drugs before cannabis. Early-onset internalizing disorders were predictors of gateway violations, and both internalizing and externalizing disorders increased the risks of dependence among users of all drugs. Conclusions. Drug use initiation follows a strong normative pattern, deviations from which are not strongly predictive of later problems. By contrast, adolescents who have already developed mental health problems are at risk for deviations from the normative sequence of drug initiation and for the development of dependence.
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C03	`13`	`X`	`FRE`	`@0 Homme @5 18`
C03	`13`	`X`	`ENG`	`@0 Human @5 18`
C03	`13`	`X`	`SPA`	`@0 Hombre @5 18`
C03	`14`	`X`	`FRE`	`@0 Ordre apparition @4 INC @5 86`
C07	`01`	`X`	`FRE`	`@0 Cannabidaceae @2 NS`
C07	`01`	`X`	`ENG`	`@0 Cannabidaceae @2 NS`
C07	`01`	`X`	`SPA`	`@0 Cannabidaceae @2 NS`
C07	`02`	`X`	`FRE`	`@0 Dicotyledones @2 NS`
C07	`02`	`X`	`ENG`	`@0 Dicotyledones @2 NS`
C07	`02`	`X`	`SPA`	`@0 Dicotyledones @2 NS`
C07	`03`	`X`	`FRE`	`@0 Angiospermae @2 NS`
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C07	`04`	`X`	`FRE`	`@0 Spermatophyta @2 NS`
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C07	`05`	`X`	`FRE`	`@0 Amérique du Nord @2 NG`
C07	`05`	`X`	`ENG`	`@0 North America @2 NG`
C07	`05`	`X`	`SPA`	`@0 America del norte @2 NG`
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C07	`06`	`X`	`ENG`	`@0 America @2 NG`
C07	`06`	`X`	`SPA`	`@0 America @2 NG`
N21				`@1 145`

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alcoholic beverage</term>
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<term>Illicit drug</term>
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<term>Cannabis</term>
<term>Santé publique</term>
<term>Santé mentale</term>
<term>Environnement social</term>
<term>Etats-Unis</term>
<term>Homme</term>
<term>Ordre apparition</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Toxicomanie</term>
<term>Consommation</term>
<term>Tabac</term>
<term>Boisson alcoolisée</term>
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<front><div type="abstract" xml:lang="en">Background. The 'gateway' pattern of drug initiation describes a normative sequence, beginning with alcohol and tobacco use, followed by cannabis, then other illicit drugs. Previous work has suggested that 'violations' of this sequence may be predictors of later problems but other determinants were not considered. We have examined the role of pre-existing mental disorders and sociodemographics in explaining the predictive effects of violations using data from the US National Comorbidity Survey Replication (NCS-R). Method. The NCS-R is a nationally representative face-to-face household survey of 9282 English-speaking respondents aged 18 years and older that used the World Health Organization (WHO) Composite International Diagnostic Interview (CIDI) to assess DSM-IV mental and substance disorders. Drug initiation was estimated using retrospective age-of-onset reports and 'violations' defined as inconsistent with the normative initiation order. Predictors of violations were examined using multivariable logistic regressions. Discrete-time survival analysis was used to see whether violations predicted progression to dependence. Results. Gateway violations were largely unrelated to later dependence risk, with the exception of small increases in risk of alcohol and other illicit drug dependence for those who initiated use of other illicit drugs before cannabis. Early-onset internalizing disorders were predictors of gateway violations, and both internalizing and externalizing disorders increased the risks of dependence among users of all drugs. Conclusions. Drug use initiation follows a strong normative pattern, deviations from which are not strongly predictive of later problems. By contrast, adolescents who have already developed mental health problems are at risk for deviations from the normative sequence of drug initiation and for the development of dependence.</div>
</front>
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<fA08 i1="01" i2="1" l="ENG"><s1>Does the 'gateway' matter? Associations between the order of drug use initiation and the development of drug dependence in the National Comorbidity Study Replication</s1>
</fA08>
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</fA11>
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</fA11>
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</fA11>
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</fA11>
<fA11 i1="08" i2="1"><s1>SAMPSON (N.)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>SWENDSEN (J.)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>KESSLER (R. C.)</s1>
</fA11>
<fA14 i1="01"><s1>National Drug and Alcohol Research Centre, University of NSW</s1>
<s2>Sydney, NSW</s2>
<s3>AUS</s3>
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<fA14 i1="02"><s1>Department of Health Care Policy, Harvard Medical School</s1>
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<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
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<fA14 i1="03"><s1>Division of Epidemiology, Services and Prevention Research, National Institute on Drug Abuse, US National Institutes of Health</s1>
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<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
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<fA14 i1="04"><s1>Department of Psychology, Wesleyan University</s1>
<s2>Middletown, CT</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>National Institute of Mental Health</s1>
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<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Psychopathology Research Laboratory, University of Bordeaux</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>9 aut.</sZ>
</fA14>
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<fC01 i1="01" l="ENG"><s0>Background. The 'gateway' pattern of drug initiation describes a normative sequence, beginning with alcohol and tobacco use, followed by cannabis, then other illicit drugs. Previous work has suggested that 'violations' of this sequence may be predictors of later problems but other determinants were not considered. We have examined the role of pre-existing mental disorders and sociodemographics in explaining the predictive effects of violations using data from the US National Comorbidity Survey Replication (NCS-R). Method. The NCS-R is a nationally representative face-to-face household survey of 9282 English-speaking respondents aged 18 years and older that used the World Health Organization (WHO) Composite International Diagnostic Interview (CIDI) to assess DSM-IV mental and substance disorders. Drug initiation was estimated using retrospective age-of-onset reports and 'violations' defined as inconsistent with the normative initiation order. Predictors of violations were examined using multivariable logistic regressions. Discrete-time survival analysis was used to see whether violations predicted progression to dependence. Results. Gateway violations were largely unrelated to later dependence risk, with the exception of small increases in risk of alcohol and other illicit drug dependence for those who initiated use of other illicit drugs before cannabis. Early-onset internalizing disorders were predictors of gateway violations, and both internalizing and externalizing disorders increased the risks of dependence among users of all drugs. Conclusions. Drug use initiation follows a strong normative pattern, deviations from which are not strongly predictive of later problems. By contrast, adolescents who have already developed mental health problems are at risk for deviations from the normative sequence of drug initiation and for the development of dependence.</s0>
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Does the 'gateway' matter? Associations between the order of drug use initiation and the development of drug dependence in the National Comorbidity Study Replication

Does the 'gateway' matter? Associations between the order of drug use initiation and the development of drug dependence in the National Comorbidity Study Replication

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