AustralieFrV1, PascalFrancis, Curation, bibRecord, 003157

Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children : report from an international working group

Identifieur interne : 003157 ( PascalFrancis/Curation ); précédent : 003156; suivant : 003158

Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children : report from an international working group

Auteurs : Francesco Rodeghiero [Italie] ; Roberto Stasi [Italie] ; Terry Gernsheimer [États-Unis] ; Marc Michel [France] ; Drew Provan [Royaume-Uni] ; Donald M. Arnold [États-Unis] ; James B. Bussel [États-Unis] ; Douglas B. Cines [États-Unis] ; Beng H. Chong [Australie] ; Nichola Cooper [Royaume-Uni] ; Bertrand Godeau [France] ; Klaus Lechner [Autriche] ; Maria Gabriella Mazzucconi [Italie] ; Robert Mcmillan [États-Unis] ; Miguel A. Sanz [Espagne] ; Paul Imbach [Suisse] ; Victor Blanchette [États-Unis] ; Thomas Kühne [Suisse] ; Marco Ruggeri [Italie] ; James N. George [États-Unis]

Source :

Blood [ 0006-4971 ] ; 2009.

RBID : Pascal:09-0185117

Descripteurs français

Pascal (Inist)
- Purpura thrombocytopénique immun, Normalisation, Terminologie, Définition, Pronostic, Adulte, Enfant, International, Hématologie, Thrombocyte.
Wicri :
- topic : Normalisation, Terminologie, Adulte, Enfant.

English descriptors

KwdEn :
- Adult, Child, Definition, Hematology, Immune thrombocytopenic purpura, International, Platelet, Prognosis, Standardization, Terminology.

Abstract

Diagnosis and management of immune thrombocytopenic purpura (ITP) remain largely dependent on clinical expertise and observations more than on evidence derived from clinical trials of high scientific quality. One major obstacle to the implementation of such studies and in producing reliable meta-analyses of existing data is a lack of consensus on standardized critical definitions, outcome criteria, and terminology. Moreover, the demand for comparative clinical trials has dramatically increased since the introduction of new classes of therapeutic agents, such as thrombopoietin receptor agonists, and innovative treatment modalities, such as anti-CD 20 antibodies. To overcome the present heterogeneity, an International Working Group of recognized expert clinicians convened a 2-day structured meeting (the Vicenza Consensus Conference) to define standard terminology and definitions for primary ITP and its different phases and criteria for the grading of severity, and clinically meaningful outcomes and response. These consensus criteria and definitions could be used by investigational clinical trials or cohort studies. Adoption of these recommendations would serve to improve communication among investigators, to enhance comparability among clinical trials, to facilitate meta-analyses and development of therapeutic guidelines, and to provide a standardized framework for regulatory agencies.

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Le document en format XML

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<author><name sortKey="Sanz, Miguel A" sort="Sanz, Miguel A" uniqKey="Sanz M" first="Miguel A." last="Sanz">Miguel A. Sanz</name>
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<author><name sortKey="Blanchette, Victor" sort="Blanchette, Victor" uniqKey="Blanchette V" first="Victor" last="Blanchette">Victor Blanchette</name>
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<author><name sortKey="Kuhne, Thomas" sort="Kuhne, Thomas" uniqKey="Kuhne T" first="Thomas" last="Kühne">Thomas Kühne</name>
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<author><name sortKey="Ruggeri, Marco" sort="Ruggeri, Marco" uniqKey="Ruggeri M" first="Marco" last="Ruggeri">Marco Ruggeri</name>
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<author><name sortKey="George, James N" sort="George, James N" uniqKey="George J" first="James N." last="George">James N. George</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children : report from an international working group</title>
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<s2>Créteil</s2>
<s3>FRA</s3>
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<sZ>11 aut.</sZ>
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<author><name sortKey="Gabriella Mazzucconi, Maria" sort="Gabriella Mazzucconi, Maria" uniqKey="Gabriella Mazzucconi M" first="Maria" last="Gabriella Mazzucconi">Maria Gabriella Mazzucconi</name>
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<s2>Valencia</s2>
<s3>ESP</s3>
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<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Pediatric Oncology/Hematology, University Children's Hospital Basel</s1>
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<s3>CHE</s3>
<sZ>16 aut.</sZ>
<sZ>18 aut.</sZ>
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<author><name sortKey="Blanchette, Victor" sort="Blanchette, Victor" uniqKey="Blanchette V" first="Victor" last="Blanchette">Victor Blanchette</name>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Division of Hematology/Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto</s1>
<s2>Toronto, ON</s2>
<s3>USA</s3>
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<author><name sortKey="Kuhne, Thomas" sort="Kuhne, Thomas" uniqKey="Kuhne T" first="Thomas" last="Kühne">Thomas Kühne</name>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Pediatric Oncology/Hematology, University Children's Hospital Basel</s1>
<s2>Basel</s2>
<s3>CHE</s3>
<sZ>16 aut.</sZ>
<sZ>18 aut.</sZ>
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<country>Suisse</country>
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<author><name sortKey="Ruggeri, Marco" sort="Ruggeri, Marco" uniqKey="Ruggeri M" first="Marco" last="Ruggeri">Marco Ruggeri</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Hematology, San Bortolo Hospital</s1>
<s2>Vicenza</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>19 aut.</sZ>
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<country>Italie</country>
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<author><name sortKey="George, James N" sort="George, James N" uniqKey="George J" first="James N." last="George">James N. George</name>
<affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Hematology-Oncology Section, College of Medicine, Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma Health Sciences Center</s1>
<s2>Oklahoma City</s2>
<s3>USA</s3>
<sZ>20 aut.</sZ>
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</analytic>
<series><title level="j" type="main">Blood</title>
<title level="j" type="abbreviated">Blood</title>
<idno type="ISSN">0006-4971</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Child</term>
<term>Definition</term>
<term>Hematology</term>
<term>Immune thrombocytopenic purpura</term>
<term>International</term>
<term>Platelet</term>
<term>Prognosis</term>
<term>Standardization</term>
<term>Terminology</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Purpura thrombocytopénique immun</term>
<term>Normalisation</term>
<term>Terminologie</term>
<term>Définition</term>
<term>Pronostic</term>
<term>Adulte</term>
<term>Enfant</term>
<term>International</term>
<term>Hématologie</term>
<term>Thrombocyte</term>
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<front><div type="abstract" xml:lang="en">Diagnosis and management of immune thrombocytopenic purpura (ITP) remain largely dependent on clinical expertise and observations more than on evidence derived from clinical trials of high scientific quality. One major obstacle to the implementation of such studies and in producing reliable meta-analyses of existing data is a lack of consensus on standardized critical definitions, outcome criteria, and terminology. Moreover, the demand for comparative clinical trials has dramatically increased since the introduction of new classes of therapeutic agents, such as thrombopoietin receptor agonists, and innovative treatment modalities, such as anti-CD 20 antibodies. To overcome the present heterogeneity, an International Working Group of recognized expert clinicians convened a 2-day structured meeting (the Vicenza Consensus Conference) to define standard terminology and definitions for primary ITP and its different phases and criteria for the grading of severity, and clinically meaningful outcomes and response. These consensus criteria and definitions could be used by investigational clinical trials or cohort studies. Adoption of these recommendations would serve to improve communication among investigators, to enhance comparability among clinical trials, to facilitate meta-analyses and development of therapeutic guidelines, and to provide a standardized framework for regulatory agencies.</div>
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<fA08 i1="01" i2="1" l="ENG"><s1>Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children : report from an international working group</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>RODEGHIERO (Francesco)</s1>
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<fA11 i1="02" i2="1"><s1>STASI (Roberto)</s1>
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<sZ>2 aut.</sZ>
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<s3>USA</s3>
<sZ>3 aut.</sZ>
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<fA14 i1="04"><s1>Université Paris 12, Faculté de Medecine, Assistance Publique-Hôpitaux de Paris (AP-HP), Hopital Henri Mondor, Service de Medecine Interne</s1>
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<s3>FRA</s3>
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<fA14 i1="06"><s1>Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University</s1>
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<sZ>8 aut.</sZ>
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<s3>AUS</s3>
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<fA14 i1="10"><s1>Department of Medicine, St George Clinical School, University of New South Wales</s1>
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<fA14 i1="12"><s1>Department of Internal Medicine I, Division of Haematology and Haemostaseology, Medical University of Vienna</s1>
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<s3>AUT</s3>
<sZ>12 aut.</sZ>
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<fA14 i1="13"><s1>Department of Cellular Biotechnology and Hematology, La Sapienza University</s1>
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<s3>ITA</s3>
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<fA14 i1="14"><s1>Scripps Research Institute</s1>
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<fA14 i1="15"><s1>Hematology Service, Hospital Universitario La Fe</s1>
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<sZ>16 aut.</sZ>
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<fA14 i1="17"><s1>Division of Hematology/Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto</s1>
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<sZ>17 aut.</sZ>
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<fA14 i1="18"><s1>Hematology-Oncology Section, College of Medicine, Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma Health Sciences Center</s1>
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Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children : report from an international working group

Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children : report from an international working group

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