Serveur d'exploration sur les relations entre la France et l'Australie

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Early Responsiveness of Women with Osteoporosis to Teriparatide After Therapy with Alendronate or Risedronate

Identifieur interne : 002E11 ( PascalFrancis/Curation ); précédent : 002E10; suivant : 002E12

Early Responsiveness of Women with Osteoporosis to Teriparatide After Therapy with Alendronate or Risedronate

Auteurs : Paul D. Miller [États-Unis] ; Pierre D. Delmas [France] ; Robert Lindsay [États-Unis] ; Nelson B. Watts [États-Unis] ; Marjorie Luckey [États-Unis] ; Jonathan Adachi [Canada] ; Kenneth Saag [États-Unis] ; Susan L. Greenspan [États-Unis] ; Ego Seeman [Australie] ; Steven Boonen [Belgique] ; Suzanne Meeves [États-Unis] ; Thomas F. Lang [États-Unis] ; John P. Bilezikian [États-Unis]

Source :

RBID : Pascal:08-0499193

Descripteurs français

English descriptors

Abstract

Background: Anabolic responsiveness to teriparatide can be blunted or delayed in patients previously treated with alendronate. The extent of this effect is different for other antiresorptives. This study evaluated the early anabolic effects of teriparatide in postmenopausal women with osteoporosis previously treated with alendronate or risedronate. Methods: Patients treated for at least 24 months with alendronate or risedronate discontinued their bisphosphonate and received teriparatide for 12 months. The primary endpoint was a comparison of changes from baseline in N-terminal propeptide of type 1 collagen after 3 months between prior bisphosphonate groups. We also examined changes in other bone turnover markers, bone mineral density (BMD), and relationships between early changes in bone turnover markers and 12-month areal and volumetric BMD. Results: In the prior risedronate group, the N-terminal propeptide of type 1 collagen increase was significantly greater after 3 months of teriparatide than in the prior alendronate group (mean ± SE, 86.0 ± 5.6 vs. 61.2 ± 5.3 ng/ml, respectively; P < 0.001). Findings were similar for the other bone turnover markers. The changes in areal BMD and trabecular spine volumetric BMD were also greater in the prior risedronate group (P < 0.05). Early changes in bone turnover markers correlated with changes in trabecular spine volumetric BMD at 12 months (Spearman r = 0.45). Teriparatide was well tolerated. Conclusion: This nonrandomized but prospective study suggests that there may be differences in anabolic responsiveness to teriparatide as a function of the type of prior bisphosphonate exposure.
pA  
A01 01  1    @0 0021-972X
A02 01      @0 JCEMAZ
A03   1    @0 J. clin. endocrinol. metab.
A05       @2 93
A06       @2 10
A08 01  1  ENG  @1 Early Responsiveness of Women with Osteoporosis to Teriparatide After Therapy with Alendronate or Risedronate
A11 01  1    @1 MILLER (Paul D.)
A11 02  1    @1 DELMAS (Pierre D.)
A11 03  1    @1 LINDSAY (Robert)
A11 04  1    @1 WATTS (Nelson B.)
A11 05  1    @1 LUCKEY (Marjorie)
A11 06  1    @1 ADACHI (Jonathan)
A11 07  1    @1 SAAG (Kenneth)
A11 08  1    @1 GREENSPAN (Susan L.)
A11 09  1    @1 SEEMAN (Ego)
A11 10  1    @1 BOONEN (Steven)
A11 11  1    @1 MEEVES (Suzanne)
A11 12  1    @1 LANG (Thomas F.)
A11 13  1    @1 BILEZIKIAN (John P.)
A14 01      @1 Colorado Center for Bone Research @2 Lakewood, Colorado 80227 @3 USA @Z 1 aut.
A14 02      @1 Institut National de la Santé et de la Recherche Médicale Research Unit 831 and Claude Bernard University Lyon 1 @2 69372 Lyon @3 FRA @Z 2 aut.
A14 03      @1 Regional Bone Center Helen Hayes Hospital @2 West Haverstraw, New York 10993 @3 USA @Z 3 aut.
A14 04      @1 University of Cincinnati Bone Health and Osteoporosis Center @2 Cincinnati, Ohio 45219 @3 USA @Z 4 aut.
A14 05      @1 St. Barnabas Osteoporosis Center @2 Livingston, New Jersey 07039 @3 USA @Z 5 aut.
A14 06      @1 St. Joseph's Healthcare McMaster University @2 Hamilton, Ontario, L8S4L8 @3 CAN @Z 6 aut.
A14 07      @1 Division of Clinical Immunology and Rheumatology University of Alabama at Birmingham @2 Birmingham, Alabama 35233 @3 USA @Z 7 aut.
A14 08      @1 University of Pittsburgh Medical Center @2 Pittsburgh, Pennsylvania 15213 @3 USA @Z 8 aut.
A14 09      @1 Endocrinology Department Austin Health, University of Melbourne @2 Victoria 3010 @3 AUS @Z 9 aut.
A14 10      @1 Bone Research Unit Leuven University, Department of Experimental Medicine @2 3000 Leuven @3 BEL @Z 10 aut.
A14 11      @1 Sanofi-aventis @2 Bridgewater, New Jersey 08807 @3 USA @Z 11 aut.
A14 12      @1 Department of Radiology Center for Molecular and Functional Imaging, University of California at San Francisco @2 San Francisco, California 94107 @3 USA @Z 12 aut.
A14 13      @1 Division of Endocrinology Metabolic Bone Diseases Unit, Columbia University College of Physicians and Surgeons @2 New York, New York 10021 @3 USA @Z 13 aut.
A17 01  1    @1 Open-label Study to Determine How Prior Therapy with Alendronate or Risedronate in Postmenopausal Women with Osteoporosis Influences the Clinical Effectiveness of Teriparatide Investigators @3 INC
A20       @1 3785-3793
A21       @1 2008
A23 01      @0 ENG
A43 01      @1 INIST @2 6022 @5 354000184256870180
A44       @0 0000 @1 © 2008 INIST-CNRS. All rights reserved.
A45       @0 30 ref.
A47 01  1    @0 08-0499193
A60       @1 P
A61       @0 A
A64 01  1    @0 The Journal of clinical endocrinology and metabolism
A66 01      @0 USA
C01 01    ENG  @0 Background: Anabolic responsiveness to teriparatide can be blunted or delayed in patients previously treated with alendronate. The extent of this effect is different for other antiresorptives. This study evaluated the early anabolic effects of teriparatide in postmenopausal women with osteoporosis previously treated with alendronate or risedronate. Methods: Patients treated for at least 24 months with alendronate or risedronate discontinued their bisphosphonate and received teriparatide for 12 months. The primary endpoint was a comparison of changes from baseline in N-terminal propeptide of type 1 collagen after 3 months between prior bisphosphonate groups. We also examined changes in other bone turnover markers, bone mineral density (BMD), and relationships between early changes in bone turnover markers and 12-month areal and volumetric BMD. Results: In the prior risedronate group, the N-terminal propeptide of type 1 collagen increase was significantly greater after 3 months of teriparatide than in the prior alendronate group (mean ± SE, 86.0 ± 5.6 vs. 61.2 ± 5.3 ng/ml, respectively; P < 0.001). Findings were similar for the other bone turnover markers. The changes in areal BMD and trabecular spine volumetric BMD were also greater in the prior risedronate group (P < 0.05). Early changes in bone turnover markers correlated with changes in trabecular spine volumetric BMD at 12 months (Spearman r = 0.45). Teriparatide was well tolerated. Conclusion: This nonrandomized but prospective study suggests that there may be differences in anabolic responsiveness to teriparatide as a function of the type of prior bisphosphonate exposure.
C02 01  X    @0 002A16E
C02 02  X    @0 002A28
C02 03  X    @0 002B21
C03 01  X  FRE  @0 Ostéoporose @5 01
C03 01  X  ENG  @0 Osteoporosis @5 01
C03 01  X  SPA  @0 Osteoporosis @5 01
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C03 02  X  ENG  @0 Early @5 02
C03 02  X  SPA  @0 Precoz @5 02
C03 03  X  FRE  @0 Homme @5 03
C03 03  X  ENG  @0 Human @5 03
C03 03  X  SPA  @0 Hombre @5 03
C03 04  X  FRE  @0 Tériparatide @2 NK @2 FR @5 04
C03 04  X  ENG  @0 Teriparatide @2 NK @2 FR @5 04
C03 04  X  SPA  @0 Teriparatida @2 NK @2 FR @5 04
C03 05  X  FRE  @0 Femelle @5 05
C03 05  X  ENG  @0 Female @5 05
C03 05  X  SPA  @0 Hembra @5 05
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C03 06  X  SPA  @0 Mujer @5 06
C03 07  X  FRE  @0 Acide alendronique @2 NK @2 FR @5 07
C03 07  X  ENG  @0 Alendronic acid @2 NK @2 FR @5 07
C03 07  X  SPA  @0 Acido alendrónico @2 NK @2 FR @5 07
C03 08  X  FRE  @0 Adulte @5 08
C03 08  X  ENG  @0 Adult @5 08
C03 08  X  SPA  @0 Adulto @5 08
C03 09  X  FRE  @0 Traitement @5 09
C03 09  X  ENG  @0 Treatment @5 09
C03 09  X  SPA  @0 Tratamiento @5 09
C03 10  X  FRE  @0 Acide risédronique @2 NK @2 FR @5 10
C03 10  X  ENG  @0 Risedronic acid @2 NK @2 FR @5 10
C03 10  X  SPA  @0 Acido risedrónico @2 NK @2 FR @5 10
C03 11  X  FRE  @0 Endocrinologie @5 11
C03 11  X  ENG  @0 Endocrinology @5 11
C03 11  X  SPA  @0 Endocrinología @5 11
C03 12  X  FRE  @0 Maladie métabolique @5 12
C03 12  X  ENG  @0 Metabolic diseases @5 12
C03 12  X  SPA  @0 Metabolismo patología @5 12
C03 13  X  FRE  @0 Nutrition @5 17
C03 13  X  ENG  @0 Nutrition @5 17
C03 13  X  SPA  @0 Nutrición @5 17
C03 14  X  FRE  @0 Obésité @5 18
C03 14  X  ENG  @0 Obesity @5 18
C03 14  X  SPA  @0 Obesidad @5 18
C03 15  X  FRE  @0 Antiostéoporotique @5 25
C03 15  X  ENG  @0 Antiosteoporotic @5 25
C03 15  X  SPA  @0 Antiosteoporótico @5 25
C03 16  X  FRE  @0 Antirésorptif @5 26
C03 16  X  ENG  @0 Antiresorptive agent @5 26
C03 16  X  SPA  @0 Antirresortivo @5 26
C03 17  X  FRE  @0 Etat nutritionnel @5 27
C03 17  X  ENG  @0 Nutritional status @5 27
C03 17  X  SPA  @0 Estado nutricional @5 27
C07 01  X  FRE  @0 Pathologie du système ostéoarticulaire @5 37
C07 01  X  ENG  @0 Diseases of the osteoarticular system @5 37
C07 01  X  SPA  @0 Sistema osteoarticular patología @5 37
C07 02  X  FRE  @0 Ostéoformateur @5 38
C07 02  X  ENG  @0 Osteoforming @5 38
C07 02  X  SPA  @0 Osteoformador @5 38
C07 03  X  FRE  @0 Bisphosphonates @5 39
C07 03  X  ENG  @0 Bisphosphonates @5 39
C07 03  X  SPA  @0 Bisfosfonatos @5 39
C07 04  X  FRE  @0 Dérivé de l'acide diphosphonique @5 40
C07 04  X  ENG  @0 Diphosphonic acid derivatives @5 40
C07 04  X  SPA  @0 Difosfonico ácido derivado @5 40
C07 05  X  FRE  @0 Trouble de la nutrition @5 41
C07 05  X  ENG  @0 Nutrition disorder @5 41
C07 05  X  SPA  @0 Trastorno nutricíon @5 41
N21       @1 329
N44 01      @1 OTO
N82       @1 OTO

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Pascal:08-0499193

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<name sortKey="Saag, Kenneth" sort="Saag, Kenneth" uniqKey="Saag K" first="Kenneth" last="Saag">Kenneth Saag</name>
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<name sortKey="Greenspan, Susan L" sort="Greenspan, Susan L" uniqKey="Greenspan S" first="Susan L." last="Greenspan">Susan L. Greenspan</name>
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<name sortKey="Seeman, Ego" sort="Seeman, Ego" uniqKey="Seeman E" first="Ego" last="Seeman">Ego Seeman</name>
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<name sortKey="Boonen, Steven" sort="Boonen, Steven" uniqKey="Boonen S" first="Steven" last="Boonen">Steven Boonen</name>
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<title xml:lang="en" level="a">Early Responsiveness of Women with Osteoporosis to Teriparatide After Therapy with Alendronate or Risedronate</title>
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<name sortKey="Lindsay, Robert" sort="Lindsay, Robert" uniqKey="Lindsay R" first="Robert" last="Lindsay">Robert Lindsay</name>
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<name sortKey="Watts, Nelson B" sort="Watts, Nelson B" uniqKey="Watts N" first="Nelson B." last="Watts">Nelson B. Watts</name>
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<name sortKey="Luckey, Marjorie" sort="Luckey, Marjorie" uniqKey="Luckey M" first="Marjorie" last="Luckey">Marjorie Luckey</name>
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<s1>St. Barnabas Osteoporosis Center</s1>
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<sZ>5 aut.</sZ>
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<name sortKey="Adachi, Jonathan" sort="Adachi, Jonathan" uniqKey="Adachi J" first="Jonathan" last="Adachi">Jonathan Adachi</name>
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</inist:fA14>
<country>Canada</country>
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<name sortKey="Saag, Kenneth" sort="Saag, Kenneth" uniqKey="Saag K" first="Kenneth" last="Saag">Kenneth Saag</name>
<affiliation wicri:level="1">
<inist:fA14 i1="07">
<s1>Division of Clinical Immunology and Rheumatology University of Alabama at Birmingham</s1>
<s2>Birmingham, Alabama 35233</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
<author>
<name sortKey="Greenspan, Susan L" sort="Greenspan, Susan L" uniqKey="Greenspan S" first="Susan L." last="Greenspan">Susan L. Greenspan</name>
<affiliation wicri:level="1">
<inist:fA14 i1="08">
<s1>University of Pittsburgh Medical Center</s1>
<s2>Pittsburgh, Pennsylvania 15213</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
<author>
<name sortKey="Seeman, Ego" sort="Seeman, Ego" uniqKey="Seeman E" first="Ego" last="Seeman">Ego Seeman</name>
<affiliation wicri:level="1">
<inist:fA14 i1="09">
<s1>Endocrinology Department Austin Health, University of Melbourne</s1>
<s2>Victoria 3010</s2>
<s3>AUS</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
</affiliation>
</author>
<author>
<name sortKey="Boonen, Steven" sort="Boonen, Steven" uniqKey="Boonen S" first="Steven" last="Boonen">Steven Boonen</name>
<affiliation wicri:level="1">
<inist:fA14 i1="10">
<s1>Bone Research Unit Leuven University, Department of Experimental Medicine</s1>
<s2>3000 Leuven</s2>
<s3>BEL</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Belgique</country>
</affiliation>
</author>
<author>
<name sortKey="Meeves, Suzanne" sort="Meeves, Suzanne" uniqKey="Meeves S" first="Suzanne" last="Meeves">Suzanne Meeves</name>
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<s1>Sanofi-aventis</s1>
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<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
<author>
<name sortKey="Lang, Thomas F" sort="Lang, Thomas F" uniqKey="Lang T" first="Thomas F." last="Lang">Thomas F. Lang</name>
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<s1>Department of Radiology Center for Molecular and Functional Imaging, University of California at San Francisco</s1>
<s2>San Francisco, California 94107</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
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<author>
<name sortKey="Bilezikian, John P" sort="Bilezikian, John P" uniqKey="Bilezikian J" first="John P." last="Bilezikian">John P. Bilezikian</name>
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<s1>Division of Endocrinology Metabolic Bone Diseases Unit, Columbia University College of Physicians and Surgeons</s1>
<s2>New York, New York 10021</s2>
<s3>USA</s3>
<sZ>13 aut.</sZ>
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<country>États-Unis</country>
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<series>
<title level="j" type="main">The Journal of clinical endocrinology and metabolism</title>
<title level="j" type="abbreviated">J. clin. endocrinol. metab.</title>
<idno type="ISSN">0021-972X</idno>
<imprint>
<date when="2008">2008</date>
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<title level="j" type="main">The Journal of clinical endocrinology and metabolism</title>
<title level="j" type="abbreviated">J. clin. endocrinol. metab.</title>
<idno type="ISSN">0021-972X</idno>
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<keywords scheme="KwdEn" xml:lang="en">
<term>Adult</term>
<term>Alendronic acid</term>
<term>Antiosteoporotic</term>
<term>Antiresorptive agent</term>
<term>Early</term>
<term>Endocrinology</term>
<term>Female</term>
<term>Human</term>
<term>Metabolic diseases</term>
<term>Nutrition</term>
<term>Nutritional status</term>
<term>Obesity</term>
<term>Osteoporosis</term>
<term>Risedronic acid</term>
<term>Teriparatide</term>
<term>Treatment</term>
<term>Woman</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr">
<term>Ostéoporose</term>
<term>Précoce</term>
<term>Homme</term>
<term>Tériparatide</term>
<term>Femelle</term>
<term>Femme</term>
<term>Acide alendronique</term>
<term>Adulte</term>
<term>Traitement</term>
<term>Acide risédronique</term>
<term>Endocrinologie</term>
<term>Maladie métabolique</term>
<term>Nutrition</term>
<term>Obésité</term>
<term>Antiostéoporotique</term>
<term>Antirésorptif</term>
<term>Etat nutritionnel</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr">
<term>Homme</term>
<term>Femme</term>
<term>Adulte</term>
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<front>
<div type="abstract" xml:lang="en">Background: Anabolic responsiveness to teriparatide can be blunted or delayed in patients previously treated with alendronate. The extent of this effect is different for other antiresorptives. This study evaluated the early anabolic effects of teriparatide in postmenopausal women with osteoporosis previously treated with alendronate or risedronate. Methods: Patients treated for at least 24 months with alendronate or risedronate discontinued their bisphosphonate and received teriparatide for 12 months. The primary endpoint was a comparison of changes from baseline in N-terminal propeptide of type 1 collagen after 3 months between prior bisphosphonate groups. We also examined changes in other bone turnover markers, bone mineral density (BMD), and relationships between early changes in bone turnover markers and 12-month areal and volumetric BMD. Results: In the prior risedronate group, the N-terminal propeptide of type 1 collagen increase was significantly greater after 3 months of teriparatide than in the prior alendronate group (mean ± SE, 86.0 ± 5.6 vs. 61.2 ± 5.3 ng/ml, respectively; P < 0.001). Findings were similar for the other bone turnover markers. The changes in areal BMD and trabecular spine volumetric BMD were also greater in the prior risedronate group (P < 0.05). Early changes in bone turnover markers correlated with changes in trabecular spine volumetric BMD at 12 months (Spearman r = 0.45). Teriparatide was well tolerated. Conclusion: This nonrandomized but prospective study suggests that there may be differences in anabolic responsiveness to teriparatide as a function of the type of prior bisphosphonate exposure.</div>
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<sZ>11 aut.</sZ>
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<s0>Background: Anabolic responsiveness to teriparatide can be blunted or delayed in patients previously treated with alendronate. The extent of this effect is different for other antiresorptives. This study evaluated the early anabolic effects of teriparatide in postmenopausal women with osteoporosis previously treated with alendronate or risedronate. Methods: Patients treated for at least 24 months with alendronate or risedronate discontinued their bisphosphonate and received teriparatide for 12 months. The primary endpoint was a comparison of changes from baseline in N-terminal propeptide of type 1 collagen after 3 months between prior bisphosphonate groups. We also examined changes in other bone turnover markers, bone mineral density (BMD), and relationships between early changes in bone turnover markers and 12-month areal and volumetric BMD. Results: In the prior risedronate group, the N-terminal propeptide of type 1 collagen increase was significantly greater after 3 months of teriparatide than in the prior alendronate group (mean ± SE, 86.0 ± 5.6 vs. 61.2 ± 5.3 ng/ml, respectively; P < 0.001). Findings were similar for the other bone turnover markers. The changes in areal BMD and trabecular spine volumetric BMD were also greater in the prior risedronate group (P < 0.05). Early changes in bone turnover markers correlated with changes in trabecular spine volumetric BMD at 12 months (Spearman r = 0.45). Teriparatide was well tolerated. Conclusion: This nonrandomized but prospective study suggests that there may be differences in anabolic responsiveness to teriparatide as a function of the type of prior bisphosphonate exposure.</s0>
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<s5>41</s5>
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<fN82>
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