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Six-month outcomes in a multinational Registry of patients hospitalized with an Acute Coronary syndrome (the Global Registry of Acute Coronary Events [GRACE])

Identifieur interne : 001476 ( PascalFrancis/Curation ); précédent : 001475; suivant : 001477

Six-month outcomes in a multinational Registry of patients hospitalized with an Acute Coronary syndrome (the Global Registry of Acute Coronary Events [GRACE])

Auteurs : Robert J. Goldberg [États-Unis, Australie, France, Canada, Royaume-Uni] ; Kristen Currie ; Kami White ; David Brieger ; Phillippe Gabriel Steg ; Shaun G. Goodman ; Omar Dabbous ; Keith A. A. Fox ; Joel M. Gore

Source :

RBID : Pascal:04-0575415

Descripteurs français

English descriptors

Abstract

Relatively limited data are available, particularly from the perspective of a multinational registry, about the post-discharge outcomes and management practices of patients with an acute coronary syndrome (ACS). The objectives of this longitudinal study were to examine 6-month outcomes in a large multinational sample of patients hospitalized with an ACS. A total of 5,476 patients with ST-segment elevation acute myocardial infarction (STEAMI), 5,209 patients with non-ST-segment elevation acute myocardial infarction (NSTEAMI), and 6,149 patients with unstable angina pectoris discharged from 90 hospitals in 14 countries comprised the study population. The study sample was recruited from 18 cluster sites in 14 countries that are currently collaborating in the Global Registry of Acute Coronary Events (GRACE) study. The 6-month post-discharge death rates were 4.8% in patients with STEAMI, 6.2% in patients with NSTEAMI, and 3.6% in patients with unstable angina pectoris. Approximately 1 in 5 of each of our comparison groups were rehospitalized for heart disease during the 6-month follow-up, and approximately 15% of each of the respective study cohorts underwent coronary revascularization during follow-up. Demographic and clinical characteristics of post-discharge decedents were identified according to type of ACS. Our results suggest that a considerable proportion of patients who were discharged from the hospital after an ACS, with some differences noted according to type of ACS, remain at increased risk for adverse outcomes during the relatively brief post-discharge period. These data suggest the need for better long-term medical management and more intense follow-up of patients with an ACS to improve their long-term outlook.
pA  
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A08 01  1  ENG  @1 Six-month outcomes in a multinational Registry of patients hospitalized with an Acute Coronary syndrome (the Global Registry of Acute Coronary Events [GRACE])
A11 01  1    @1 GOLDBERG (Robert J.)
A11 02  1    @1 CURRIE (Kristen)
A11 03  1    @1 WHITE (Kami)
A11 04  1    @1 BRIEGER (David)
A11 05  1    @1 STEG (Phillippe Gabriel)
A11 06  1    @1 GOODMAN (Shaun G.)
A11 07  1    @1 DABBOUS (Omar)
A11 08  1    @1 FOX (Keith A. A.)
A11 09  1    @1 GORE (Joel M.)
A14 01      @1 Department of Medicine, Division of Cardiovascular Medicine and Center for Outcomes Research, University of Massachusetts Medical School @2 Worcester, Massachusetts @3 USA
A14 02      @1 Concord Hospital @2 Sydney @3 AUS
A14 03      @1 Service de Cardiologie, Hôpital Bichat @2 Paris @3 FRA
A14 04      @1 Canadian Heart Research Centre and Terrence Donnelly Heart Center, Division of Cardiology, St. Michael's Hospital, University of Toronto @2 Toronto, Ontario @3 CAN
A14 05      @1 Department of Cardiology, The University and the Royal Infirmary of Edinburgh @2 Edinburgh @3 GBR
A20       @1 288-293
A21       @1 2004
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C01 01    ENG  @0 Relatively limited data are available, particularly from the perspective of a multinational registry, about the post-discharge outcomes and management practices of patients with an acute coronary syndrome (ACS). The objectives of this longitudinal study were to examine 6-month outcomes in a large multinational sample of patients hospitalized with an ACS. A total of 5,476 patients with ST-segment elevation acute myocardial infarction (STEAMI), 5,209 patients with non-ST-segment elevation acute myocardial infarction (NSTEAMI), and 6,149 patients with unstable angina pectoris discharged from 90 hospitals in 14 countries comprised the study population. The study sample was recruited from 18 cluster sites in 14 countries that are currently collaborating in the Global Registry of Acute Coronary Events (GRACE) study. The 6-month post-discharge death rates were 4.8% in patients with STEAMI, 6.2% in patients with NSTEAMI, and 3.6% in patients with unstable angina pectoris. Approximately 1 in 5 of each of our comparison groups were rehospitalized for heart disease during the 6-month follow-up, and approximately 15% of each of the respective study cohorts underwent coronary revascularization during follow-up. Demographic and clinical characteristics of post-discharge decedents were identified according to type of ACS. Our results suggest that a considerable proportion of patients who were discharged from the hospital after an ACS, with some differences noted according to type of ACS, remain at increased risk for adverse outcomes during the relatively brief post-discharge period. These data suggest the need for better long-term medical management and more intense follow-up of patients with an ACS to improve their long-term outlook.
C02 01  X    @0 002B12A03
C03 01  X  FRE  @0 Cardiopathie coronaire @5 01
C03 01  X  ENG  @0 Coronary heart disease @5 01
C03 01  X  SPA  @0 Cardiopatía coronaria @5 01
C03 02  X  FRE  @0 Pronostic @5 02
C03 02  X  ENG  @0 Prognosis @5 02
C03 02  X  SPA  @0 Pronóstico @5 02
C03 03  X  FRE  @0 Evolution @5 03
C03 03  X  ENG  @0 Evolution @5 03
C03 03  X  SPA  @0 Evolución @5 03
C03 04  X  FRE  @0 Homme @5 05
C03 04  X  ENG  @0 Human @5 05
C03 04  X  SPA  @0 Hombre @5 05
C03 05  X  FRE  @0 Aigu @5 06
C03 05  X  ENG  @0 Acute @5 06
C03 05  X  SPA  @0 Agudo @5 06
C03 06  X  FRE  @0 Artère coronaire @5 08
C03 06  X  ENG  @0 Coronary artery @5 08
C03 06  X  SPA  @0 Arteria coronaria @5 08
C07 01  X  FRE  @0 Appareil circulatoire pathologie @5 37
C07 01  X  ENG  @0 Cardiovascular disease @5 37
C07 01  X  SPA  @0 Aparato circulatorio patología @5 37
N21       @1 327
N44 01      @1 OTO
N82       @1 OTO

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