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Multicenter linkage study of schizophrenia loci on chromosome 22q

Identifieur interne : 001405 ( PascalFrancis/Curation ); précédent : 001404; suivant : 001406

Multicenter linkage study of schizophrenia loci on chromosome 22q

Auteurs : B. J. Mowry [Australie] ; P. A. Holmans [Royaume-Uni] ; A. E. Pulver [États-Unis] ; P. V. Gejman [États-Unis] ; B. Riley [États-Unis] ; N. M. Williams [Royaume-Uni] ; C. Laurent [France] ; S. G. Schwab [Allemagne] ; D. B. Wildenauer [Allemagne] ; S. Bauche [France] ; M. J. Owen [Royaume-Uni] ; B. Wormley [États-Unis] ; A. R. Sanders [États-Unis] ; G. Nestadt [États-Unis] ; K. Y. Liang [États-Unis] ; J. Duan [États-Unis] ; R. Ribble [États-Unis] ; N. Norton [Royaume-Uni] ; S. Soubigou [France] ; W. Maier [Allemagne] ; K. R. Ewen-White [Australie] ; N. Demarchi [Italie] ; B. Carpenter [États-Unis] ; D. Walsh [Irlande (pays)] ; H. Williams [Royaume-Uni] ; M. Jay [France] ; M. Albus [Allemagne] ; D. A. Nertney [Australie] ; G. Papadimitriou [Grèce] ; A. O'Neill [Royaume-Uni] ; M. C. O'Donovan [Royaume-Uni] ; J.-F. Deleuze [France] ; F. B. Lerer [Israël] ; D. Dikeos [Grèce] ; K. S. Kendler [États-Unis] ; J. Mallet [France] ; J. M. Silverman [États-Unis] ; R. R. Crowe [États-Unis] ; D. F. Levinson [États-Unis]

Source :

RBID : Pascal:04-0482945

Descripteurs français

English descriptors

Abstract

The hypothesis of the existence of one or more schizophrenia susceptibility loci on chromosome 22q is supported by reports of genetic linkage and association, meta-analyses of linkage, and the observation of elevated risk for psychosis in people with velocardiofacial syndrome, caused by 22q11 microdeletions. We tested this hypothesis by evaluating 10 microsatellite markers spanning 22q in a multicenter sample of 779 pedigrees. We also incorporated age at onset and sex into the analysis as covariates. No significant evidence for linkage to schizophrenia or for linkage associated with earlier age at onset, gender, or heterogeneity across sites was observed. We interpret these findings to mean that the population-wide effects of putative 22q schizophrenia susceptibility loci are too weak to detect with linkaae analvsis even in larae samples.
pA  
A01 01  1    @0 1359-4184
A03   1    @0 Mol. psychiatry
A05       @2 9
A06       @2 8
A08 01  1  ENG  @1 Multicenter linkage study of schizophrenia loci on chromosome 22q
A11 01  1    @1 MOWRY (B. J.)
A11 02  1    @1 HOLMANS (P. A.)
A11 03  1    @1 PULVER (A. E.)
A11 04  1    @1 GEJMAN (P. V.)
A11 05  1    @1 RILEY (B.)
A11 06  1    @1 WILLIAMS (N. M.)
A11 07  1    @1 LAURENT (C.)
A11 08  1    @1 SCHWAB (S. G.)
A11 09  1    @1 WILDENAUER (D. B.)
A11 10  1    @1 BAUCHE (S.)
A11 11  1    @1 OWEN (M. J.)
A11 12  1    @1 WORMLEY (B.)
A11 13  1    @1 SANDERS (A. R.)
A11 14  1    @1 NESTADT (G.)
A11 15  1    @1 LIANG (K. Y.)
A11 16  1    @1 DUAN (J.)
A11 17  1    @1 RIBBLE (R.)
A11 18  1    @1 NORTON (N.)
A11 19  1    @1 SOUBIGOU (S.)
A11 20  1    @1 MAIER (W.)
A11 21  1    @1 EWEN-WHITE (K. R.)
A11 22  1    @1 DEMARCHI (N.)
A11 23  1    @1 CARPENTER (B.)
A11 24  1    @1 WALSH (D.)
A11 25  1    @1 WILLIAMS (H.)
A11 26  1    @1 JAY (M.)
A11 27  1    @1 ALBUS (M.)
A11 28  1    @1 NERTNEY (D. A.)
A11 29  1    @1 PAPADIMITRIOU (G.)
A11 30  1    @1 O'NEILL (A.)
A11 31  1    @1 O'DONOVAN (M. C.)
A11 32  1    @1 DELEUZE (J.-F.)
A11 33  1    @1 LERER (F. B.)
A11 34  1    @1 DIKEOS (D.)
A11 35  1    @1 KENDLER (K. S.)
A11 36  1    @1 MALLET (J.)
A11 37  1    @1 SILVERMAN (J. M.)
A11 38  1    @1 CROWE (R. R.)
A11 39  1    @1 LEVINSON (D. F.)
A14 01      @1 Queensland Centre for Mental Health Research, The Park - Centre for Mental Health @2 Wacol, Queensland @3 AUS @Z 1 aut. @Z 28 aut.
A14 02      @1 Department of Psychiatry, University of Queensland @2 Brisbane, Queensland @3 AUS @Z 1 aut.
A14 03      @1 MRC Biostatistics Unit @2 Cambridge @3 GBR @Z 2 aut.
A14 04      @1 Department of Psychiatry, Johns Hopkins University School of Medicine @2 Baltimore, MD @3 USA @Z 3 aut. @Z 14 aut.
A14 05      @1 North western University, ENH Research Institute @2 Evanston, IL @3 USA @Z 4 aut. @Z 13 aut. @Z 16 aut. @Z 23 aut.
A14 06      @1 Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University @2 Richmond, VA @3 USA @Z 5 aut. @Z 12 aut. @Z 13 aut. @Z 17 aut. @Z 35 aut.
A14 07      @1 Department of Psychological Medicine, University of Wales College of Medicine @2 Cardiff @3 GBR @Z 6 aut. @Z 11 aut. @Z 18 aut. @Z 25 aut. @Z 31 aut.
A14 08      @1 Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs, Centre National de la Recherche Scientifique, Hôpital de la Pitié Salpêtrière @2 Paris @3 FRA @Z 7 aut. @Z 10 aut. @Z 26 aut. @Z 36 aut.
A14 09      @1 Department of Psychiatry, University of Bonn @2 Bonn @3 DEU @Z 8 aut. @Z 9 aut. @Z 20 aut.
A14 10      @1 Department of Biostatistics, Johns Hopkins University Bloomberg School of Public Health @2 Baltimore, MD @3 USA @Z 15 aut.
A14 11      @1 Aventis Pharma SA @2 Evry @3 FRA @Z 19 aut. @Z 32 aut.
A14 12      @1 Australian Genome Research Facility, Walter and Eliza Hall Institute of Medical Research @2 Parkville, Victoria @3 AUS @Z 21 aut.
A14 13      @1 Clinica Psichiatrica, Seconda Universita degli Studi di Napoli @2 Naples @3 ITA @Z 22 aut.
A14 14      @1 The Health Research Board @2 Dublin @3 IRL @Z 24 aut.
A14 15      @1 State Mental Hospital @2 Haar @3 DEU @Z 27 aut.
A14 16      @1 Department of Psychiatry, University of Athens Medical School @2 Athens @3 GRC @Z 29 aut. @Z 34 aut.
A14 17      @1 Department of Psychiatry, Queens University @2 Belfast @3 GBR @Z 30 aut.
A14 18      @1 Department of Psychiatry, Hadassah-Hebrew University Medical Center @2 Jerusalem @3 ISR @Z 33 aut.
A14 19      @1 Department of Psychiatry, Mt Sinai School of Medicine @2 New York, NY @3 USA @Z 37 aut.
A14 20      @1 Mental Health Clinical Research Center and Department of Psychiatry, The University of Iowa College of Medicine @2 Iowa City, IW @3 USA @Z 38 aut.
A14 21      @1 Department of Psychiatry, University of Pennsylvania @2 Philadelphia, PA @3 USA @Z 39 aut.
A20       @1 784-795
A21       @1 2004
A23 01      @0 ENG
A43 01      @1 INIST @2 26439 @5 354000114066680040
A44       @0 0000 @1 © 2004 INIST-CNRS. All rights reserved.
A45       @0 81 ref.
A47 01  1    @0 04-0482945
A60       @1 P
A61       @0 A
A64 01  1    @0 Molecular psychiatry
A66 01      @0 GBR
C01 01    ENG  @0 The hypothesis of the existence of one or more schizophrenia susceptibility loci on chromosome 22q is supported by reports of genetic linkage and association, meta-analyses of linkage, and the observation of elevated risk for psychosis in people with velocardiofacial syndrome, caused by 22q11 microdeletions. We tested this hypothesis by evaluating 10 microsatellite markers spanning 22q in a multicenter sample of 779 pedigrees. We also incorporated age at onset and sex into the analysis as covariates. No significant evidence for linkage to schizophrenia or for linkage associated with earlier age at onset, gender, or heterogeneity across sites was observed. We interpret these findings to mean that the population-wide effects of putative 22q schizophrenia susceptibility loci are too weak to detect with linkaae analvsis even in larae samples.
C02 01  X    @0 002B18C06A
C02 02  X    @0 002A03
C03 01  X  FRE  @0 Schizophrénie @5 01
C03 01  X  ENG  @0 Schizophrenia @5 01
C03 01  X  SPA  @0 Esquizofrenia @5 01
C03 02  X  FRE  @0 Etude multicentrique @5 04
C03 02  X  ENG  @0 Multicenter study @5 04
C03 02  X  SPA  @0 Estudio multicéntrico @5 04
C03 03  X  FRE  @0 Liaison génétique @5 05
C03 03  X  ENG  @0 Genetic linkage @5 05
C03 03  X  SPA  @0 Ligamiento genético @5 05
C03 04  X  FRE  @0 DNA microsatellite @5 06
C03 04  X  ENG  @0 Microsatellite DNA @5 06
C03 04  X  SPA  @0 DNA microsatélite @5 06
C03 05  X  FRE  @0 Délétion @5 07
C03 05  X  ENG  @0 Deletion @5 07
C03 05  X  SPA  @0 Deleción @5 07
C03 06  X  FRE  @0 Vélocardiofacial syndrome @2 NM @5 10
C03 06  X  ENG  @0 Velocardiofacial syndrome @2 NM @5 10
C03 06  X  SPA  @0 Velocardiofacial síndrome @2 NM @5 10
C03 07  X  FRE  @0 Gène candidat @5 13
C03 07  X  ENG  @0 Candidate gene @5 13
C03 07  X  SPA  @0 Gen candidato @5 13
C03 08  X  FRE  @0 Homme @5 20
C03 08  X  ENG  @0 Human @5 20
C03 08  X  SPA  @0 Hombre @5 20
C03 09  X  FRE  @0 Age apparition @5 23
C03 09  X  ENG  @0 Age of onset @5 23
C03 09  X  SPA  @0 Edad aparición @5 23
C03 10  X  FRE  @0 Marqueur génétique @5 24
C03 10  X  ENG  @0 Genetic marker @5 24
C03 10  X  SPA  @0 Marcador genético @5 24
C03 11  X  FRE  @0 Dimorphisme sexuel @5 35
C03 11  X  ENG  @0 Sexual dimorphism @5 35
C03 11  X  SPA  @0 Dimorfismo sexual @5 35
C07 01  X  FRE  @0 Psychose @5 37
C07 01  X  ENG  @0 Psychosis @5 37
C07 01  X  SPA  @0 Psicosis @5 37
C07 02  X  FRE  @0 Aberration chromosomique @5 53
C07 02  X  ENG  @0 Chromosomal aberration @5 53
C07 02  X  SPA  @0 Aberración cromosómica @5 53
C07 03  X  FRE  @0 Chromosome anormal @5 54
C07 03  X  ENG  @0 Abnormal chromosome @5 54
C07 03  X  SPA  @0 Cromosoma anormal @5 54
N21       @1 271
N44 01      @1 PSI
N82       @1 PSI

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Pascal:04-0482945

Le document en format XML

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<name sortKey="Sanders, A R" sort="Sanders, A R" uniqKey="Sanders A" first="A. R." last="Sanders">A. R. Sanders</name>
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<name sortKey="Nestadt, G" sort="Nestadt, G" uniqKey="Nestadt G" first="G." last="Nestadt">G. Nestadt</name>
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<s1>Department of Psychiatry, Johns Hopkins University School of Medicine</s1>
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<name sortKey="Liang, K Y" sort="Liang, K Y" uniqKey="Liang K" first="K. Y." last="Liang">K. Y. Liang</name>
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<name sortKey="Duan, J" sort="Duan, J" uniqKey="Duan J" first="J." last="Duan">J. Duan</name>
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<name sortKey="Ribble, R" sort="Ribble, R" uniqKey="Ribble R" first="R." last="Ribble">R. Ribble</name>
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<name sortKey="Norton, N" sort="Norton, N" uniqKey="Norton N" first="N." last="Norton">N. Norton</name>
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<name sortKey="Soubigou, S" sort="Soubigou, S" uniqKey="Soubigou S" first="S." last="Soubigou">S. Soubigou</name>
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<title xml:lang="en" level="a">Multicenter linkage study of schizophrenia loci on chromosome 22q</title>
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<name sortKey="Schwab, S G" sort="Schwab, S G" uniqKey="Schwab S" first="S. G." last="Schwab">S. G. Schwab</name>
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<s1>Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs, Centre National de la Recherche Scientifique, Hôpital de la Pitié Salpêtrière</s1>
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<name sortKey="Owen, M J" sort="Owen, M J" uniqKey="Owen M" first="M. J." last="Owen">M. J. Owen</name>
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<s1>Department of Psychological Medicine, University of Wales College of Medicine</s1>
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<name sortKey="Wormley, B" sort="Wormley, B" uniqKey="Wormley B" first="B." last="Wormley">B. Wormley</name>
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<s1>Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University</s1>
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<s1>North western University, ENH Research Institute</s1>
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<s1>Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University</s1>
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<s1>Department of Psychiatry, Johns Hopkins University School of Medicine</s1>
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<name sortKey="Duan, J" sort="Duan, J" uniqKey="Duan J" first="J." last="Duan">J. Duan</name>
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<name sortKey="Ribble, R" sort="Ribble, R" uniqKey="Ribble R" first="R." last="Ribble">R. Ribble</name>
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<name sortKey="Norton, N" sort="Norton, N" uniqKey="Norton N" first="N." last="Norton">N. Norton</name>
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<name sortKey="Maier, W" sort="Maier, W" uniqKey="Maier W" first="W." last="Maier">W. Maier</name>
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<sZ>9 aut.</sZ>
<sZ>20 aut.</sZ>
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<name sortKey="Walsh, D" sort="Walsh, D" uniqKey="Walsh D" first="D." last="Walsh">D. Walsh</name>
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<s1>The Health Research Board</s1>
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</inist:fA14>
<country>Irlande (pays)</country>
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<author>
<name sortKey="Williams, H" sort="Williams, H" uniqKey="Williams H" first="H." last="Williams">H. Williams</name>
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<author>
<name sortKey="Jay, M" sort="Jay, M" uniqKey="Jay M" first="M." last="Jay">M. Jay</name>
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<inist:fA14 i1="08">
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<s2>Paris</s2>
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<sZ>10 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author>
<name sortKey="Albus, M" sort="Albus, M" uniqKey="Albus M" first="M." last="Albus">M. Albus</name>
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<inist:fA14 i1="15">
<s1>State Mental Hospital</s1>
<s2>Haar</s2>
<s3>DEU</s3>
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</inist:fA14>
<country>Allemagne</country>
</affiliation>
</author>
<author>
<name sortKey="Nertney, D A" sort="Nertney, D A" uniqKey="Nertney D" first="D. A." last="Nertney">D. A. Nertney</name>
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<inist:fA14 i1="01">
<s1>Queensland Centre for Mental Health Research, The Park - Centre for Mental Health</s1>
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<sZ>28 aut.</sZ>
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<country>Australie</country>
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</author>
<author>
<name sortKey="Papadimitriou, G" sort="Papadimitriou, G" uniqKey="Papadimitriou G" first="G." last="Papadimitriou">G. Papadimitriou</name>
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<inist:fA14 i1="16">
<s1>Department of Psychiatry, University of Athens Medical School</s1>
<s2>Athens</s2>
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<sZ>29 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Grèce</country>
</affiliation>
</author>
<author>
<name sortKey="O Neill, A" sort="O Neill, A" uniqKey="O Neill A" first="A." last="O'Neill">A. O'Neill</name>
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<inist:fA14 i1="17">
<s1>Department of Psychiatry, Queens University</s1>
<s2>Belfast</s2>
<s3>GBR</s3>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author>
<name sortKey="O Donovan, M C" sort="O Donovan, M C" uniqKey="O Donovan M" first="M. C." last="O'Donovan">M. C. O'Donovan</name>
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<s1>Department of Psychological Medicine, University of Wales College of Medicine</s1>
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<sZ>11 aut.</sZ>
<sZ>18 aut.</sZ>
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<country>Royaume-Uni</country>
</affiliation>
</author>
<author>
<name sortKey="Deleuze, J F" sort="Deleuze, J F" uniqKey="Deleuze J" first="J.-F." last="Deleuze">J.-F. Deleuze</name>
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<inist:fA14 i1="11">
<s1>Aventis Pharma SA</s1>
<s2>Evry</s2>
<s3>FRA</s3>
<sZ>19 aut.</sZ>
<sZ>32 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author>
<name sortKey="Lerer, F B" sort="Lerer, F B" uniqKey="Lerer F" first="F. B." last="Lerer">F. B. Lerer</name>
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<inist:fA14 i1="18">
<s1>Department of Psychiatry, Hadassah-Hebrew University Medical Center</s1>
<s2>Jerusalem</s2>
<s3>ISR</s3>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>Israël</country>
</affiliation>
</author>
<author>
<name sortKey="Dikeos, D" sort="Dikeos, D" uniqKey="Dikeos D" first="D." last="Dikeos">D. Dikeos</name>
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<inist:fA14 i1="16">
<s1>Department of Psychiatry, University of Athens Medical School</s1>
<s2>Athens</s2>
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<sZ>29 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Grèce</country>
</affiliation>
</author>
<author>
<name sortKey="Kendler, K S" sort="Kendler, K S" uniqKey="Kendler K" first="K. S." last="Kendler">K. S. Kendler</name>
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<s1>Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University</s1>
<s2>Richmond, VA</s2>
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<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>17 aut.</sZ>
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<country>États-Unis</country>
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<author>
<name sortKey="Mallet, J" sort="Mallet, J" uniqKey="Mallet J" first="J." last="Mallet">J. Mallet</name>
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<s1>Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs, Centre National de la Recherche Scientifique, Hôpital de la Pitié Salpêtrière</s1>
<s2>Paris</s2>
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<sZ>10 aut.</sZ>
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<author>
<name sortKey="Silverman, J M" sort="Silverman, J M" uniqKey="Silverman J" first="J. M." last="Silverman">J. M. Silverman</name>
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<s1>Department of Psychiatry, Mt Sinai School of Medicine</s1>
<s2>New York, NY</s2>
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</inist:fA14>
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</affiliation>
</author>
<author>
<name sortKey="Crowe, R R" sort="Crowe, R R" uniqKey="Crowe R" first="R. R." last="Crowe">R. R. Crowe</name>
<affiliation wicri:level="1">
<inist:fA14 i1="20">
<s1>Mental Health Clinical Research Center and Department of Psychiatry, The University of Iowa College of Medicine</s1>
<s2>Iowa City, IW</s2>
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</author>
<author>
<name sortKey="Levinson, D F" sort="Levinson, D F" uniqKey="Levinson D" first="D. F." last="Levinson">D. F. Levinson</name>
<affiliation wicri:level="1">
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<s1>Department of Psychiatry, University of Pennsylvania</s1>
<s2>Philadelphia, PA</s2>
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<sZ>39 aut.</sZ>
</inist:fA14>
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</analytic>
<series>
<title level="j" type="main">Molecular psychiatry</title>
<title level="j" type="abbreviated">Mol. psychiatry</title>
<idno type="ISSN">1359-4184</idno>
<imprint>
<date when="2004">2004</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt>
<title level="j" type="main">Molecular psychiatry</title>
<title level="j" type="abbreviated">Mol. psychiatry</title>
<idno type="ISSN">1359-4184</idno>
</seriesStmt>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Age of onset</term>
<term>Candidate gene</term>
<term>Deletion</term>
<term>Genetic linkage</term>
<term>Genetic marker</term>
<term>Human</term>
<term>Microsatellite DNA</term>
<term>Multicenter study</term>
<term>Schizophrenia</term>
<term>Sexual dimorphism</term>
<term>Velocardiofacial syndrome</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr">
<term>Schizophrénie</term>
<term>Etude multicentrique</term>
<term>Liaison génétique</term>
<term>DNA microsatellite</term>
<term>Délétion</term>
<term>Vélocardiofacial syndrome</term>
<term>Gène candidat</term>
<term>Homme</term>
<term>Age apparition</term>
<term>Marqueur génétique</term>
<term>Dimorphisme sexuel</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr">
<term>Homme</term>
</keywords>
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</teiHeader>
<front>
<div type="abstract" xml:lang="en">The hypothesis of the existence of one or more schizophrenia susceptibility loci on chromosome 22q is supported by reports of genetic linkage and association, meta-analyses of linkage, and the observation of elevated risk for psychosis in people with velocardiofacial syndrome, caused by 22q11 microdeletions. We tested this hypothesis by evaluating 10 microsatellite markers spanning 22q in a multicenter sample of 779 pedigrees. We also incorporated age at onset and sex into the analysis as covariates. No significant evidence for linkage to schizophrenia or for linkage associated with earlier age at onset, gender, or heterogeneity across sites was observed. We interpret these findings to mean that the population-wide effects of putative 22q schizophrenia susceptibility loci are too weak to detect with linkaae analvsis even in larae samples.</div>
</front>
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<s1>Multicenter linkage study of schizophrenia loci on chromosome 22q</s1>
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<s1>MOWRY (B. J.)</s1>
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<s1>LERER (F. B.)</s1>
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<s1>DIKEOS (D.)</s1>
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<s1>KENDLER (K. S.)</s1>
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<s1>MALLET (J.)</s1>
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<s1>LEVINSON (D. F.)</s1>
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<fA14 i1="01">
<s1>Queensland Centre for Mental Health Research, The Park - Centre for Mental Health</s1>
<s2>Wacol, Queensland</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>28 aut.</sZ>
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<fA14 i1="02">
<s1>Department of Psychiatry, University of Queensland</s1>
<s2>Brisbane, Queensland</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
</fA14>
<fA14 i1="03">
<s1>MRC Biostatistics Unit</s1>
<s2>Cambridge</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
</fA14>
<fA14 i1="04">
<s1>Department of Psychiatry, Johns Hopkins University School of Medicine</s1>
<s2>Baltimore, MD</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>14 aut.</sZ>
</fA14>
<fA14 i1="05">
<s1>North western University, ENH Research Institute</s1>
<s2>Evanston, IL</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>23 aut.</sZ>
</fA14>
<fA14 i1="06">
<s1>Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University</s1>
<s2>Richmond, VA</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>35 aut.</sZ>
</fA14>
<fA14 i1="07">
<s1>Department of Psychological Medicine, University of Wales College of Medicine</s1>
<s2>Cardiff</s2>
<s3>GBR</s3>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>31 aut.</sZ>
</fA14>
<fA14 i1="08">
<s1>Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs, Centre National de la Recherche Scientifique, Hôpital de la Pitié Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>36 aut.</sZ>
</fA14>
<fA14 i1="09">
<s1>Department of Psychiatry, University of Bonn</s1>
<s2>Bonn</s2>
<s3>DEU</s3>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>20 aut.</sZ>
</fA14>
<fA14 i1="10">
<s1>Department of Biostatistics, Johns Hopkins University Bloomberg School of Public Health</s1>
<s2>Baltimore, MD</s2>
<s3>USA</s3>
<sZ>15 aut.</sZ>
</fA14>
<fA14 i1="11">
<s1>Aventis Pharma SA</s1>
<s2>Evry</s2>
<s3>FRA</s3>
<sZ>19 aut.</sZ>
<sZ>32 aut.</sZ>
</fA14>
<fA14 i1="12">
<s1>Australian Genome Research Facility, Walter and Eliza Hall Institute of Medical Research</s1>
<s2>Parkville, Victoria</s2>
<s3>AUS</s3>
<sZ>21 aut.</sZ>
</fA14>
<fA14 i1="13">
<s1>Clinica Psichiatrica, Seconda Universita degli Studi di Napoli</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>22 aut.</sZ>
</fA14>
<fA14 i1="14">
<s1>The Health Research Board</s1>
<s2>Dublin</s2>
<s3>IRL</s3>
<sZ>24 aut.</sZ>
</fA14>
<fA14 i1="15">
<s1>State Mental Hospital</s1>
<s2>Haar</s2>
<s3>DEU</s3>
<sZ>27 aut.</sZ>
</fA14>
<fA14 i1="16">
<s1>Department of Psychiatry, University of Athens Medical School</s1>
<s2>Athens</s2>
<s3>GRC</s3>
<sZ>29 aut.</sZ>
<sZ>34 aut.</sZ>
</fA14>
<fA14 i1="17">
<s1>Department of Psychiatry, Queens University</s1>
<s2>Belfast</s2>
<s3>GBR</s3>
<sZ>30 aut.</sZ>
</fA14>
<fA14 i1="18">
<s1>Department of Psychiatry, Hadassah-Hebrew University Medical Center</s1>
<s2>Jerusalem</s2>
<s3>ISR</s3>
<sZ>33 aut.</sZ>
</fA14>
<fA14 i1="19">
<s1>Department of Psychiatry, Mt Sinai School of Medicine</s1>
<s2>New York, NY</s2>
<s3>USA</s3>
<sZ>37 aut.</sZ>
</fA14>
<fA14 i1="20">
<s1>Mental Health Clinical Research Center and Department of Psychiatry, The University of Iowa College of Medicine</s1>
<s2>Iowa City, IW</s2>
<s3>USA</s3>
<sZ>38 aut.</sZ>
</fA14>
<fA14 i1="21">
<s1>Department of Psychiatry, University of Pennsylvania</s1>
<s2>Philadelphia, PA</s2>
<s3>USA</s3>
<sZ>39 aut.</sZ>
</fA14>
<fA20>
<s1>784-795</s1>
</fA20>
<fA21>
<s1>2004</s1>
</fA21>
<fA23 i1="01">
<s0>ENG</s0>
</fA23>
<fA43 i1="01">
<s1>INIST</s1>
<s2>26439</s2>
<s5>354000114066680040</s5>
</fA43>
<fA44>
<s0>0000</s0>
<s1>© 2004 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45>
<s0>81 ref.</s0>
</fA45>
<fA47 i1="01" i2="1">
<s0>04-0482945</s0>
</fA47>
<fA60>
<s1>P</s1>
</fA60>
<fA61>
<s0>A</s0>
</fA61>
<fA64 i1="01" i2="1">
<s0>Molecular psychiatry</s0>
</fA64>
<fA66 i1="01">
<s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG">
<s0>The hypothesis of the existence of one or more schizophrenia susceptibility loci on chromosome 22q is supported by reports of genetic linkage and association, meta-analyses of linkage, and the observation of elevated risk for psychosis in people with velocardiofacial syndrome, caused by 22q11 microdeletions. We tested this hypothesis by evaluating 10 microsatellite markers spanning 22q in a multicenter sample of 779 pedigrees. We also incorporated age at onset and sex into the analysis as covariates. No significant evidence for linkage to schizophrenia or for linkage associated with earlier age at onset, gender, or heterogeneity across sites was observed. We interpret these findings to mean that the population-wide effects of putative 22q schizophrenia susceptibility loci are too weak to detect with linkaae analvsis even in larae samples.</s0>
</fC01>
<fC02 i1="01" i2="X">
<s0>002B18C06A</s0>
</fC02>
<fC02 i1="02" i2="X">
<s0>002A03</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE">
<s0>Schizophrénie</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG">
<s0>Schizophrenia</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA">
<s0>Esquizofrenia</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE">
<s0>Etude multicentrique</s0>
<s5>04</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG">
<s0>Multicenter study</s0>
<s5>04</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA">
<s0>Estudio multicéntrico</s0>
<s5>04</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE">
<s0>Liaison génétique</s0>
<s5>05</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG">
<s0>Genetic linkage</s0>
<s5>05</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA">
<s0>Ligamiento genético</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE">
<s0>DNA microsatellite</s0>
<s5>06</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG">
<s0>Microsatellite DNA</s0>
<s5>06</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA">
<s0>DNA microsatélite</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE">
<s0>Délétion</s0>
<s5>07</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG">
<s0>Deletion</s0>
<s5>07</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA">
<s0>Deleción</s0>
<s5>07</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE">
<s0>Vélocardiofacial syndrome</s0>
<s2>NM</s2>
<s5>10</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG">
<s0>Velocardiofacial syndrome</s0>
<s2>NM</s2>
<s5>10</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA">
<s0>Velocardiofacial síndrome</s0>
<s2>NM</s2>
<s5>10</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE">
<s0>Gène candidat</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG">
<s0>Candidate gene</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA">
<s0>Gen candidato</s0>
<s5>13</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE">
<s0>Homme</s0>
<s5>20</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG">
<s0>Human</s0>
<s5>20</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA">
<s0>Hombre</s0>
<s5>20</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE">
<s0>Age apparition</s0>
<s5>23</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG">
<s0>Age of onset</s0>
<s5>23</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA">
<s0>Edad aparición</s0>
<s5>23</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE">
<s0>Marqueur génétique</s0>
<s5>24</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG">
<s0>Genetic marker</s0>
<s5>24</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA">
<s0>Marcador genético</s0>
<s5>24</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE">
<s0>Dimorphisme sexuel</s0>
<s5>35</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG">
<s0>Sexual dimorphism</s0>
<s5>35</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA">
<s0>Dimorfismo sexual</s0>
<s5>35</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE">
<s0>Psychose</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG">
<s0>Psychosis</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA">
<s0>Psicosis</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE">
<s0>Aberration chromosomique</s0>
<s5>53</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG">
<s0>Chromosomal aberration</s0>
<s5>53</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA">
<s0>Aberración cromosómica</s0>
<s5>53</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE">
<s0>Chromosome anormal</s0>
<s5>54</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG">
<s0>Abnormal chromosome</s0>
<s5>54</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA">
<s0>Cromosoma anormal</s0>
<s5>54</s5>
</fC07>
<fN21>
<s1>271</s1>
</fN21>
<fN44 i1="01">
<s1>PSI</s1>
</fN44>
<fN82>
<s1>PSI</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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   |wiki=    Wicri/Asie
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   |texte=   Multicenter linkage study of schizophrenia loci on chromosome 22q
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