AustralieFrV1, PascalFrancis, Curation, bibRecord, 000696

Respiratory virus infections after stem cell transplantation: a prospective study from the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation

Identifieur interne : 000696 ( PascalFrancis/Curation ); précédent : 000695; suivant : 000697

Respiratory virus infections after stem cell transplantation: a prospective study from the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation

Auteurs : P. Ljungman [Suède] ; K. N. Ward [Royaume-Uni] ; B. N. A. Crooks [Royaume-Uni] ; A. Parker [Royaume-Uni] ; R. Martino [Espagne] ; P. J. Shaw [Australie] ; L. Brinch [Norvège] ; M. Brune [Suède] ; R. De La Camara [Espagne] ; A. Dekker [Pays-Bas] ; K. Pauksen [Suède] ; N. Russell [Royaume-Uni] ; A. P. Schwarer [Australie] ; C. Cordonnier [France]

Source :

Bone marrow transplantation : (Basingstoke) [ 0268-3369 ] ; 2001.

RBID : Pascal:02-0000478

Descripteurs français

Pascal (Inist)
- Homogreffe, Autogreffe, Cellule hématopoïétique, Cellule souche, Complication, Infection communautaire, Infection, Appareil respiratoire, Virus grippal A, Virus respiratoire syncytial humain, Incidence, Pronostic, Homme.
Wicri :
- topic : Cellule souche, Homme.

English descriptors

KwdEn :
- Autograft, Community acquired infection, Complication, Hematopoietic cell, Homograft, Human, Human respiratory syncytial virus, Incidence, Infection, Influenza A virus, Prognosis, Respiratory system, Stem cell.

Abstract

Community-acquired respiratory virus infections are a cause of mortality after stem cell transplantation (SCT). A prospective study was performed at 37 centers to determine their frequency and importance. Additional cases were also collected to allow the analysis of risk factors for severe infection. Forty episodes were collected in the prospective study and 53 additional episodes through subsequent case collection. The frequency of documented respiratory virus infections was 3.5% among 819 allogeneic and 0.4% among 1154 autologous SCT patients transplanted during the study period. The frequency of lower respiratory tract infections (LRTI) was 2.1% among allogeneic and 0.2% among autologous SCT patients. The mortality within 28 days from diagnosis of a respiratory viral infection was 1.1% among allogeneic SCT while no autologous SCT patient died. The deaths of five patients (0.6%) were directly attributed to a respiratory virus infection (three RSV; two influenza A). On multivariate analysis, lymphocytopenia increased the risk for LRTI (P = 0.008). Lymphocytopenia was also a significant risk factor for LRTI in patients with RSV infections. The overall mortality in RSV infection was 30.4% and the direct RSV-associated mortality was 17.4%. For influenza A virus infection, the corresponding percentages were 23.0% and 15.3%. This prospective study supports the fact that community-acquired respiratory virus infections cause transplant-related mortality after SCT.

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A02	`01`			`@0 BMTRE9`
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A08	`01`	`1`	`ENG`	`@1 Respiratory virus infections after stem cell transplantation: a prospective study from the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation`
A11	`01`	`1`		`@1 LJUNGMAN (P.)`
A11	`02`	`1`		`@1 WARD (K. N.)`
A11	`03`	`1`		`@1 CROOKS (B. N. A.)`
A11	`04`	`1`		`@1 PARKER (A.)`
A11	`05`	`1`		`@1 MARTINO (R.)`
A11	`06`	`1`		`@1 SHAW (P. J.)`
A11	`07`	`1`		`@1 BRINCH (L.)`
A11	`08`	`1`		`@1 BRUNE (M.)`
A11	`09`	`1`		`@1 DE LA CAMARA (R.)`
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A11	`11`	`1`		`@1 PAUKSEN (K.)`
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A11	`13`	`1`		`@1 SCHWARER (A. P.)`
A11	`14`	`1`		`@1 CORDONNIER (C.)`
A14	`01`			`@1 Huddinge University Hospital, Karolinska Institutet @2 Stockholm @3 SWE @Z 1 aut.`
A14	`02`			`@1 Royal Free and University College Medical School @2 London @3 GBR @Z 2 aut.`
A14	`03`			`@1 Newcastle General Hospital @2 Newcastle upon Tyne @3 GBR @Z 3 aut.`
A14	`04`			`@1 Glasgow Royal Infirmary @2 Glasgow @3 GBR @Z 4 aut.`
A14	`05`			`@1 Hopital Santa Creu i Sant Pau @2 Barcelona @3 ESP @Z 5 aut.`
A14	`06`			`@1 New Children's Hospital @2 Sydney @3 AUS @Z 6 aut.`
A14	`07`			`@1 Rikshospitalet @2 Oslo @3 NOR @Z 7 aut.`
A14	`08`			`@1 Sahlgren's Hospital @2 Gothenburg @3 SWE @Z 8 aut.`
A14	`09`			`@1 Hopital de la Princesa @2 Madrid @3 ESP @Z 9 aut.`
A14	`10`			`@1 University Hospital @2 Utrecht @3 NLD @Z 10 aut.`
A14	`11`			`@1 Uppsala University Hospital @2 Uppsala @3 SWE @Z 11 aut.`
A14	`12`			`@1 Nottingham City Hospital @2 Nottingham @3 GBR @Z 12 aut.`
A14	`13`			`@1 Alfred Hospital @2 Melbourne @3 AUS @Z 13 aut.`
A14	`14`			`@1 Hopital Henri Mondor @2 Creteil @3 FRA @Z 14 aut.`
A20				`@1 479-484`
A21				`@1 2001`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 21176 @5 354000096242070080`
A44				`@0 0000 @1 © 2002 INIST-CNRS. All rights reserved.`
A45				`@0 20 ref.`
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A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Bone marrow transplantation : (Basingstoke)`
A66	`01`			`@0 GBR`
C01	`01`		`ENG`	@0 Community-acquired respiratory virus infections are a cause of mortality after stem cell transplantation (SCT). A prospective study was performed at 37 centers to determine their frequency and importance. Additional cases were also collected to allow the analysis of risk factors for severe infection. Forty episodes were collected in the prospective study and 53 additional episodes through subsequent case collection. The frequency of documented respiratory virus infections was 3.5% among 819 allogeneic and 0.4% among 1154 autologous SCT patients transplanted during the study period. The frequency of lower respiratory tract infections (LRTI) was 2.1% among allogeneic and 0.2% among autologous SCT patients. The mortality within 28 days from diagnosis of a respiratory viral infection was 1.1% among allogeneic SCT while no autologous SCT patient died. The deaths of five patients (0.6%) were directly attributed to a respiratory virus infection (three RSV; two influenza A). On multivariate analysis, lymphocytopenia increased the risk for LRTI (P = 0.008). Lymphocytopenia was also a significant risk factor for LRTI in patients with RSV infections. The overall mortality in RSV infection was 30.4% and the direct RSV-associated mortality was 17.4%. For influenza A virus infection, the corresponding percentages were 23.0% and 15.3%. This prospective study supports the fact that community-acquired respiratory virus infections cause transplant-related mortality after SCT.
C02	`01`	`X`		`@0 002B27D02`
C03	`01`	`X`	`FRE`	`@0 Homogreffe @5 01`
C03	`01`	`X`	`ENG`	`@0 Homograft @5 01`
C03	`01`	`X`	`SPA`	`@0 Homoinjerto @5 01`
C03	`02`	`X`	`FRE`	`@0 Autogreffe @5 02`
C03	`02`	`X`	`ENG`	`@0 Autograft @5 02`
C03	`02`	`X`	`SPA`	`@0 Autoinjerto @5 02`
C03	`03`	`X`	`FRE`	`@0 Cellule hématopoïétique @5 03`
C03	`03`	`X`	`ENG`	`@0 Hematopoietic cell @5 03`
C03	`03`	`X`	`SPA`	`@0 Célula hematopoyética @5 03`
C03	`04`	`X`	`FRE`	`@0 Cellule souche @5 04`
C03	`04`	`X`	`ENG`	`@0 Stem cell @5 04`
C03	`04`	`X`	`SPA`	`@0 Célula primitiva @5 04`
C03	`05`	`X`	`FRE`	`@0 Complication @5 05`
C03	`05`	`X`	`ENG`	`@0 Complication @5 05`
C03	`05`	`X`	`SPA`	`@0 Complicación @5 05`
C03	`06`	`X`	`FRE`	`@0 Infection communautaire @2 NM @5 06`
C03	`06`	`X`	`ENG`	`@0 Community acquired infection @2 NM @5 06`
C03	`06`	`X`	`SPA`	`@0 Infección comunitaria @2 NM @5 06`
C03	`07`	`X`	`FRE`	`@0 Infection @5 07`
C03	`07`	`X`	`ENG`	`@0 Infection @5 07`
C03	`07`	`X`	`SPA`	`@0 Infección @5 07`
C03	`08`	`X`	`FRE`	`@0 Appareil respiratoire @5 08`
C03	`08`	`X`	`ENG`	`@0 Respiratory system @5 08`
C03	`08`	`X`	`SPA`	`@0 Aparato respiratorio @5 08`
C03	`09`	`X`	`FRE`	`@0 Virus grippal A @2 NW @5 09`
C03	`09`	`X`	`ENG`	`@0 Influenza A virus @2 NW @5 09`
C03	`09`	`X`	`SPA`	`@0 Influenza A virus @2 NW @5 09`
C03	`10`	`X`	`FRE`	`@0 Virus respiratoire syncytial humain @2 NW @5 10`
C03	`10`	`X`	`ENG`	`@0 Human respiratory syncytial virus @2 NW @5 10`
C03	`10`	`X`	`SPA`	`@0 Human respiratory syncytial virus @2 NW @5 10`
C03	`11`	`X`	`FRE`	`@0 Incidence @5 11`
C03	`11`	`X`	`ENG`	`@0 Incidence @5 11`
C03	`11`	`X`	`SPA`	`@0 Incidencia @5 11`
C03	`12`	`X`	`FRE`	`@0 Pronostic @5 12`
C03	`12`	`X`	`ENG`	`@0 Prognosis @5 12`
C03	`12`	`X`	`SPA`	`@0 Pronóstico @5 12`
C03	`13`	`X`	`FRE`	`@0 Homme @5 13`
C03	`13`	`X`	`ENG`	`@0 Human @5 13`
C03	`13`	`X`	`SPA`	`@0 Hombre @5 13`
C07	`01`	`X`	`FRE`	`@0 Influenzavirus A @2 NW`
C07	`01`	`X`	`ENG`	`@0 Influenzavirus A @2 NW`
C07	`01`	`X`	`SPA`	`@0 Influenzavirus A @2 NW`
C07	`02`	`X`	`FRE`	`@0 Orthomyxoviridae @2 NW`
C07	`02`	`X`	`ENG`	`@0 Orthomyxoviridae @2 NW`
C07	`02`	`X`	`SPA`	`@0 Orthomyxoviridae @2 NW`
C07	`03`	`X`	`FRE`	`@0 Virus @2 NW`
C07	`03`	`X`	`ENG`	`@0 Virus @2 NW`
C07	`03`	`X`	`SPA`	`@0 Virus @2 NW`
C07	`04`	`X`	`FRE`	`@0 Pneumovirus @2 NW`
C07	`04`	`X`	`ENG`	`@0 Pneumovirus @2 NW`
C07	`04`	`X`	`SPA`	`@0 Pneumovirus @2 NW`
C07	`05`	`X`	`FRE`	`@0 Pneumovirinae @2 NW`
C07	`05`	`X`	`ENG`	`@0 Pneumovirinae @2 NW`
C07	`05`	`X`	`SPA`	`@0 Pneumovirinae @2 NW`
C07	`06`	`X`	`FRE`	`@0 Paramyxoviridae @2 NW`
C07	`06`	`X`	`ENG`	`@0 Paramyxoviridae @2 NW`
C07	`06`	`X`	`SPA`	`@0 Paramyxoviridae @2 NW`
C07	`07`	`X`	`FRE`	`@0 Mononegavirales @2 NW`
C07	`07`	`X`	`ENG`	`@0 Mononegavirales @2 NW`
C07	`07`	`X`	`SPA`	`@0 Mononegavirales @2 NW`
C07	`08`	`X`	`FRE`	`@0 Greffe @5 37`
C07	`08`	`X`	`ENG`	`@0 Graft @5 37`
C07	`08`	`X`	`SPA`	`@0 Injerto @5 37`
C07	`09`	`X`	`FRE`	`@0 Appareil respiratoire pathologie @5 38`
C07	`09`	`X`	`ENG`	`@0 Respiratory disease @5 38`
C07	`09`	`X`	`SPA`	`@0 Aparato respiratorio patología @5 38`
N21				`@1 001`

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Pascal:02-0000478

Le document en format XML

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<author><name sortKey="Crooks, B N A" sort="Crooks, B N A" uniqKey="Crooks B" first="B. N. A." last="Crooks">B. N. A. Crooks</name>
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<author><name sortKey="Parker, A" sort="Parker, A" uniqKey="Parker A" first="A." last="Parker">A. Parker</name>
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<author><name sortKey="Martino, R" sort="Martino, R" uniqKey="Martino R" first="R." last="Martino">R. Martino</name>
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<author><name sortKey="Shaw, P J" sort="Shaw, P J" uniqKey="Shaw P" first="P. J." last="Shaw">P. J. Shaw</name>
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<author><name sortKey="Brinch, L" sort="Brinch, L" uniqKey="Brinch L" first="L." last="Brinch">L. Brinch</name>
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<author><name sortKey="Brune, M" sort="Brune, M" uniqKey="Brune M" first="M." last="Brune">M. Brune</name>
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<author><name sortKey="De La Camara, R" sort="De La Camara, R" uniqKey="De La Camara R" first="R." last="De La Camara">R. De La Camara</name>
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<author><name sortKey="Dekker, A" sort="Dekker, A" uniqKey="Dekker A" first="A." last="Dekker">A. Dekker</name>
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<author><name sortKey="Pauksen, K" sort="Pauksen, K" uniqKey="Pauksen K" first="K." last="Pauksen">K. Pauksen</name>
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<author><name sortKey="Russell, N" sort="Russell, N" uniqKey="Russell N" first="N." last="Russell">N. Russell</name>
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<author><name sortKey="Schwarer, A P" sort="Schwarer, A P" uniqKey="Schwarer A" first="A. P." last="Schwarer">A. P. Schwarer</name>
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<author><name sortKey="Cordonnier, C" sort="Cordonnier, C" uniqKey="Cordonnier C" first="C." last="Cordonnier">C. Cordonnier</name>
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</inist:fA14>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Respiratory virus infections after stem cell transplantation: a prospective study from the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation</title>
<author><name sortKey="Ljungman, P" sort="Ljungman, P" uniqKey="Ljungman P" first="P." last="Ljungman">P. Ljungman</name>
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<author><name sortKey="Ward, K N" sort="Ward, K N" uniqKey="Ward K" first="K. N." last="Ward">K. N. Ward</name>
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</author>
<author><name sortKey="Crooks, B N A" sort="Crooks, B N A" uniqKey="Crooks B" first="B. N. A." last="Crooks">B. N. A. Crooks</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Newcastle General Hospital</s1>
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<s3>GBR</s3>
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<author><name sortKey="Parker, A" sort="Parker, A" uniqKey="Parker A" first="A." last="Parker">A. Parker</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Glasgow Royal Infirmary</s1>
<s2>Glasgow</s2>
<s3>GBR</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author><name sortKey="Martino, R" sort="Martino, R" uniqKey="Martino R" first="R." last="Martino">R. Martino</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Hopital Santa Creu i Sant Pau</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
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</inist:fA14>
<country>Espagne</country>
</affiliation>
</author>
<author><name sortKey="Shaw, P J" sort="Shaw, P J" uniqKey="Shaw P" first="P. J." last="Shaw">P. J. Shaw</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>New Children's Hospital</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
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</inist:fA14>
<country>Australie</country>
</affiliation>
</author>
<author><name sortKey="Brinch, L" sort="Brinch, L" uniqKey="Brinch L" first="L." last="Brinch">L. Brinch</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Rikshospitalet</s1>
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<s3>NOR</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Norvège</country>
</affiliation>
</author>
<author><name sortKey="Brune, M" sort="Brune, M" uniqKey="Brune M" first="M." last="Brune">M. Brune</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Sahlgren's Hospital</s1>
<s2>Gothenburg</s2>
<s3>SWE</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Suède</country>
</affiliation>
</author>
<author><name sortKey="De La Camara, R" sort="De La Camara, R" uniqKey="De La Camara R" first="R." last="De La Camara">R. De La Camara</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Hopital de la Princesa</s1>
<s2>Madrid</s2>
<s3>ESP</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
</author>
<author><name sortKey="Dekker, A" sort="Dekker, A" uniqKey="Dekker A" first="A." last="Dekker">A. Dekker</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>University Hospital</s1>
<s2>Utrecht</s2>
<s3>NLD</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
</affiliation>
</author>
<author><name sortKey="Pauksen, K" sort="Pauksen, K" uniqKey="Pauksen K" first="K." last="Pauksen">K. Pauksen</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Uppsala University Hospital</s1>
<s2>Uppsala</s2>
<s3>SWE</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Suède</country>
</affiliation>
</author>
<author><name sortKey="Russell, N" sort="Russell, N" uniqKey="Russell N" first="N." last="Russell">N. Russell</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Nottingham City Hospital</s1>
<s2>Nottingham</s2>
<s3>GBR</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author><name sortKey="Schwarer, A P" sort="Schwarer, A P" uniqKey="Schwarer A" first="A. P." last="Schwarer">A. P. Schwarer</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Alfred Hospital</s1>
<s2>Melbourne</s2>
<s3>AUS</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Australie</country>
</affiliation>
</author>
<author><name sortKey="Cordonnier, C" sort="Cordonnier, C" uniqKey="Cordonnier C" first="C." last="Cordonnier">C. Cordonnier</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Hopital Henri Mondor</s1>
<s2>Creteil</s2>
<s3>FRA</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Bone marrow transplantation : (Basingstoke)</title>
<title level="j" type="abbreviated">Bone marrow transplant. : (Basingstoke)</title>
<idno type="ISSN">0268-3369</idno>
<imprint><date when="2001">2001</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Bone marrow transplantation : (Basingstoke)</title>
<title level="j" type="abbreviated">Bone marrow transplant. : (Basingstoke)</title>
<idno type="ISSN">0268-3369</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Autograft</term>
<term>Community acquired infection</term>
<term>Complication</term>
<term>Hematopoietic cell</term>
<term>Homograft</term>
<term>Human</term>
<term>Human respiratory syncytial virus</term>
<term>Incidence</term>
<term>Infection</term>
<term>Influenza A virus</term>
<term>Prognosis</term>
<term>Respiratory system</term>
<term>Stem cell</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Homogreffe</term>
<term>Autogreffe</term>
<term>Cellule hématopoïétique</term>
<term>Cellule souche</term>
<term>Complication</term>
<term>Infection communautaire</term>
<term>Infection</term>
<term>Appareil respiratoire</term>
<term>Virus grippal A</term>
<term>Virus respiratoire syncytial humain</term>
<term>Incidence</term>
<term>Pronostic</term>
<term>Homme</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Cellule souche</term>
<term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Community-acquired respiratory virus infections are a cause of mortality after stem cell transplantation (SCT). A prospective study was performed at 37 centers to determine their frequency and importance. Additional cases were also collected to allow the analysis of risk factors for severe infection. Forty episodes were collected in the prospective study and 53 additional episodes through subsequent case collection. The frequency of documented respiratory virus infections was 3.5% among 819 allogeneic and 0.4% among 1154 autologous SCT patients transplanted during the study period. The frequency of lower respiratory tract infections (LRTI) was 2.1% among allogeneic and 0.2% among autologous SCT patients. The mortality within 28 days from diagnosis of a respiratory viral infection was 1.1% among allogeneic SCT while no autologous SCT patient died. The deaths of five patients (0.6%) were directly attributed to a respiratory virus infection (three RSV; two influenza A). On multivariate analysis, lymphocytopenia increased the risk for LRTI (P = 0.008). Lymphocytopenia was also a significant risk factor for LRTI in patients with RSV infections. The overall mortality in RSV infection was 30.4% and the direct RSV-associated mortality was 17.4%. For influenza A virus infection, the corresponding percentages were 23.0% and 15.3%. This prospective study supports the fact that community-acquired respiratory virus infections cause transplant-related mortality after SCT.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0268-3369</s0>
</fA01>
<fA02 i1="01"><s0>BMTRE9</s0>
</fA02>
<fA03 i2="1"><s0>Bone marrow transplant. : (Basingstoke)</s0>
</fA03>
<fA05><s2>28</s2>
</fA05>
<fA06><s2>5</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Respiratory virus infections after stem cell transplantation: a prospective study from the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>LJUNGMAN (P.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>WARD (K. N.)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>CROOKS (B. N. A.)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>PARKER (A.)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>MARTINO (R.)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>SHAW (P. J.)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>BRINCH (L.)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>BRUNE (M.)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>DE LA CAMARA (R.)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>DEKKER (A.)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>PAUKSEN (K.)</s1>
</fA11>
<fA11 i1="12" i2="1"><s1>RUSSELL (N.)</s1>
</fA11>
<fA11 i1="13" i2="1"><s1>SCHWARER (A. P.)</s1>
</fA11>
<fA11 i1="14" i2="1"><s1>CORDONNIER (C.)</s1>
</fA11>
<fA14 i1="01"><s1>Huddinge University Hospital, Karolinska Institutet</s1>
<s2>Stockholm</s2>
<s3>SWE</s3>
<sZ>1 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Royal Free and University College Medical School</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Newcastle General Hospital</s1>
<s2>Newcastle upon Tyne</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Glasgow Royal Infirmary</s1>
<s2>Glasgow</s2>
<s3>GBR</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Hopital Santa Creu i Sant Pau</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>New Children's Hospital</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>Rikshospitalet</s1>
<s2>Oslo</s2>
<s3>NOR</s3>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="08"><s1>Sahlgren's Hospital</s1>
<s2>Gothenburg</s2>
<s3>SWE</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="09"><s1>Hopital de la Princesa</s1>
<s2>Madrid</s2>
<s3>ESP</s3>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="10"><s1>University Hospital</s1>
<s2>Utrecht</s2>
<s3>NLD</s3>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="11"><s1>Uppsala University Hospital</s1>
<s2>Uppsala</s2>
<s3>SWE</s3>
<sZ>11 aut.</sZ>
</fA14>
<fA14 i1="12"><s1>Nottingham City Hospital</s1>
<s2>Nottingham</s2>
<s3>GBR</s3>
<sZ>12 aut.</sZ>
</fA14>
<fA14 i1="13"><s1>Alfred Hospital</s1>
<s2>Melbourne</s2>
<s3>AUS</s3>
<sZ>13 aut.</sZ>
</fA14>
<fA14 i1="14"><s1>Hopital Henri Mondor</s1>
<s2>Creteil</s2>
<s3>FRA</s3>
<sZ>14 aut.</sZ>
</fA14>
<fA20><s1>479-484</s1>
</fA20>
<fA21><s1>2001</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>21176</s2>
<s5>354000096242070080</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2002 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>20 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>02-0000478</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Bone marrow transplantation : (Basingstoke)</s0>
</fA64>
<fA66 i1="01"><s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Community-acquired respiratory virus infections are a cause of mortality after stem cell transplantation (SCT). A prospective study was performed at 37 centers to determine their frequency and importance. Additional cases were also collected to allow the analysis of risk factors for severe infection. Forty episodes were collected in the prospective study and 53 additional episodes through subsequent case collection. The frequency of documented respiratory virus infections was 3.5% among 819 allogeneic and 0.4% among 1154 autologous SCT patients transplanted during the study period. The frequency of lower respiratory tract infections (LRTI) was 2.1% among allogeneic and 0.2% among autologous SCT patients. The mortality within 28 days from diagnosis of a respiratory viral infection was 1.1% among allogeneic SCT while no autologous SCT patient died. The deaths of five patients (0.6%) were directly attributed to a respiratory virus infection (three RSV; two influenza A). On multivariate analysis, lymphocytopenia increased the risk for LRTI (P = 0.008). Lymphocytopenia was also a significant risk factor for LRTI in patients with RSV infections. The overall mortality in RSV infection was 30.4% and the direct RSV-associated mortality was 17.4%. For influenza A virus infection, the corresponding percentages were 23.0% and 15.3%. This prospective study supports the fact that community-acquired respiratory virus infections cause transplant-related mortality after SCT.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B27D02</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Homogreffe</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Homograft</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Homoinjerto</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Autogreffe</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Autograft</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Autoinjerto</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Cellule hématopoïétique</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Hematopoietic cell</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Célula hematopoyética</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Cellule souche</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Stem cell</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Célula primitiva</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Complication</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Complication</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Complicación</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Infection communautaire</s0>
<s2>NM</s2>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Community acquired infection</s0>
<s2>NM</s2>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Infección comunitaria</s0>
<s2>NM</s2>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Infection</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Infection</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Infección</s0>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Appareil respiratoire</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Respiratory system</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Aparato respiratorio</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Virus grippal A</s0>
<s2>NW</s2>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Influenza A virus</s0>
<s2>NW</s2>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Influenza A virus</s0>
<s2>NW</s2>
<s5>09</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Virus respiratoire syncytial humain</s0>
<s2>NW</s2>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Human respiratory syncytial virus</s0>
<s2>NW</s2>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Human respiratory syncytial virus</s0>
<s2>NW</s2>
<s5>10</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Incidence</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Incidence</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Incidencia</s0>
<s5>11</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Pronostic</s0>
<s5>12</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Prognosis</s0>
<s5>12</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Pronóstico</s0>
<s5>12</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Homme</s0>
<s5>13</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Human</s0>
<s5>13</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Hombre</s0>
<s5>13</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Influenzavirus A</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Influenzavirus A</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Influenzavirus A</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Orthomyxoviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Orthomyxoviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Orthomyxoviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Pneumovirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Pneumovirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Pneumovirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Pneumovirinae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Pneumovirinae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Pneumovirinae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Paramyxoviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Paramyxoviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Paramyxoviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Mononegavirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Mononegavirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Mononegavirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Greffe</s0>
<s5>37</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Graft</s0>
<s5>37</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Injerto</s0>
<s5>37</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>38</s5>
</fC07>
<fN21><s1>001</s1>
</fN21>
</pA>
</standard>
</inist>
</record>

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Respiratory virus infections after stem cell transplantation: a prospective study from the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation

Respiratory virus infections after stem cell transplantation: a prospective study from the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation

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