AustralieFrV1, PascalFrancis, Corpus, bibRecord, 005D34

Human-chimpanzee DNA sequence variation in the four major genes of the renin angiotensin system

Identifieur interne : 005D34 ( PascalFrancis/Corpus ); précédent : 005D33; suivant : 005D35

Human-chimpanzee DNA sequence variation in the four major genes of the renin angiotensin system

Auteurs : Cécile Dufour ; Didier Casane ; Derek Denton ; Jean Wickings ; Pierre Corvol ; Xavier Jeunemaitre

Source :

Genomics : (San Diego, CA) [ 0888-7543 ] ; 2000.

RBID : Pascal:01-0049610

Descripteurs français

Pascal (Inist)
- Homme, Pan troglodytes, Système renin angiotensine, Gène, Variabilité génétique, Evolution moléculaire, Comparaison intraspécifique, Comparaison interspécifique, Pression sanguine, Hypertension artérielle, Régulation, Polymorphisme mononucléotide.

English descriptors

KwdEn :
- Blood pressure, Gene, Genetic variability, Human, Hypertension, Interspecific comparison, Intraspecific comparison, Molecular evolution, Pan troglodytes, Regulation(control), Renin angiotensin system.

Abstract

The renin angiotensin system (RAS) is involved in blood pressure control and water/sodium metabolism. The genes encoding the proteins of this system are candidate genes for essential hypertension. The RAS involves four main molecules: angiotensinogen, renin, angiotensin I-converting enzyme, and the angiotensin II type 1 receptor (encoded by the genes AGT, REN, DCP1, and AGTR1, respectively). We performed a molecular screening over 17,037 bp of the coding and 5' and 3' untranslated regions of these genes, from three to six common chimpanzees. We identified 44 single-nucleotide polymorphisms (SNPs) in chimpanzee samples, including 18 coding-region SNPs, 5 of which led to an amino acid replacement. We observed common and different features at various sites (synonymous, nonsynonymous, and noncoding) within and between the four chimpanzee genes: (1) the nucleotide diversity at noncoding sites was similar; (2) the nucleotide diversity at nonsynonymous sites was low, probably reflecting purifying selection, except for the AGT gene; (3) the nucleotide diversity at synonymous sites, which was dependent on the G+C content at the third position of the codon, was high, except for the AGTR1 gene. Comparison of the chimpanzee SNPs with those previously reported for humans identified 119 sites with fixed differences (including 62 coding sites, 17 of which resulted in amino acid differences between the species). Analysis of polymorphism within species and divergence between species shed light on the evolutionary constraints on these genes. In particular, comparison of the pattern of mutation at polymorphic and fixed sites between humans and chimpanzees suggested that the high G+C content of the DCP1 gene was maintained by positive selection at its silent sites. Finally, we propose 68 ancestral alleles for the human RAS genes and discuss the implications for their use in future hypertension-susceptibility association studies.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	PASCAL 01-0049610 INIST
ET :	Human-chimpanzee DNA sequence variation in the four major genes of the renin angiotensin system
AU :	DUFOUR (Cécile); CASANE (Didier); DENTON (Derek); WICKINGS (Jean); CORVOL (Pierre); JEUNEMAITRE (Xavier)
AF :	Pathologie Vasculaire et Endocrinologie Rénale, Collège de France, Chaire de Médecine Expérimentale et d'Endocrinologie Rénale, Institut National de la Santé et de la Recherche Médicale U36, 3, rue d'Ulm/75005 Paris/France (1 aut., 5 aut., 6 aut.); Equipe "phylogénie et évolution moléculaires," UPRESA CNRS 8080, Bâtiment 444, Université Paris-Sud/91405 Orsay/France (2 aut.); Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne/Parkville, Victoria 3052/Australie (3 aut.); Centre International de Recherche Médicale, BP 769/Franceville/Gabon (4 aut.)
DT :	Publication en série; Niveau analytique
SO :	Genomics : (San Diego, CA); ISSN 0888-7543; Etats-Unis; Da. 2000; Vol. 69; No. 1; Pp. 14-26; Bibl. 1 p.1/4
LA :	Anglais
EA :	The renin angiotensin system (RAS) is involved in blood pressure control and water/sodium metabolism. The genes encoding the proteins of this system are candidate genes for essential hypertension. The RAS involves four main molecules: angiotensinogen, renin, angiotensin I-converting enzyme, and the angiotensin II type 1 receptor (encoded by the genes AGT, REN, DCP1, and AGTR1, respectively). We performed a molecular screening over 17,037 bp of the coding and 5' and 3' untranslated regions of these genes, from three to six common chimpanzees. We identified 44 single-nucleotide polymorphisms (SNPs) in chimpanzee samples, including 18 coding-region SNPs, 5 of which led to an amino acid replacement. We observed common and different features at various sites (synonymous, nonsynonymous, and noncoding) within and between the four chimpanzee genes: (1) the nucleotide diversity at noncoding sites was similar; (2) the nucleotide diversity at nonsynonymous sites was low, probably reflecting purifying selection, except for the AGT gene; (3) the nucleotide diversity at synonymous sites, which was dependent on the G+C content at the third position of the codon, was high, except for the AGTR1 gene. Comparison of the chimpanzee SNPs with those previously reported for humans identified 119 sites with fixed differences (including 62 coding sites, 17 of which resulted in amino acid differences between the species). Analysis of polymorphism within species and divergence between species shed light on the evolutionary constraints on these genes. In particular, comparison of the pattern of mutation at polymorphic and fixed sites between humans and chimpanzees suggested that the high G+C content of the DCP1 gene was maintained by positive selection at its silent sites. Finally, we propose 68 ancestral alleles for the human RAS genes and discuss the implications for their use in future hypertension-susceptibility association studies.
CC :	002A07C01B; 002A07C03
FD :	Homme; Pan troglodytes; Système renin angiotensine; Gène; Variabilité génétique; Evolution moléculaire; Comparaison intraspécifique; Comparaison interspécifique; Pression sanguine; Hypertension artérielle; Régulation; Polymorphisme mononucléotide
FG :	Simioidea; Primates; Mammalia; Vertebrata
ED :	Human; Pan troglodytes; Renin angiotensin system; Gene; Genetic variability; Molecular evolution; Intraspecific comparison; Interspecific comparison; Blood pressure; Hypertension; Regulation(control)
EG :	Simioidea; Primates; Mammalia; Vertebrata
SD :	Hombre; Pan troglodytes; Sistema renin angiotensina; Gen; Variabilidad genética; Evolución molecular; Comparación intraespecífica; Comparación interespecífica; Presión sanguínea; Hipertensión arterial; Regulación
LO :	INIST-21389.354000092666030020
ID :	01-0049610

Links to Exploration step

Pascal:01-0049610

Le document en format XML

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<front><div type="abstract" xml:lang="en">The renin angiotensin system (RAS) is involved in blood pressure control and water/sodium metabolism. The genes encoding the proteins of this system are candidate genes for essential hypertension. The RAS involves four main molecules: angiotensinogen, renin, angiotensin I-converting enzyme, and the angiotensin II type 1 receptor (encoded by the genes AGT, REN, DCP1, and AGTR1, respectively). We performed a molecular screening over 17,037 bp of the coding and 5' and 3' untranslated regions of these genes, from three to six common chimpanzees. We identified 44 single-nucleotide polymorphisms (SNPs) in chimpanzee samples, including 18 coding-region SNPs, 5 of which led to an amino acid replacement. We observed common and different features at various sites (synonymous, nonsynonymous, and noncoding) within and between the four chimpanzee genes: (1) the nucleotide diversity at noncoding sites was similar; (2) the nucleotide diversity at nonsynonymous sites was low, probably reflecting purifying selection, except for the AGT gene; (3) the nucleotide diversity at synonymous sites, which was dependent on the G+C content at the third position of the codon, was high, except for the AGTR1 gene. Comparison of the chimpanzee SNPs with those previously reported for humans identified 119 sites with fixed differences (including 62 coding sites, 17 of which resulted in amino acid differences between the species). Analysis of polymorphism within species and divergence between species shed light on the evolutionary constraints on these genes. In particular, comparison of the pattern of mutation at polymorphic and fixed sites between humans and chimpanzees suggested that the high G+C content of the DCP1 gene was maintained by positive selection at its silent sites. Finally, we propose 68 ancestral alleles for the human RAS genes and discuss the implications for their use in future hypertension-susceptibility association studies.</div>
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<ET>Human-chimpanzee DNA sequence variation in the four major genes of the renin angiotensin system</ET>
<AU>DUFOUR (Cécile); CASANE (Didier); DENTON (Derek); WICKINGS (Jean); CORVOL (Pierre); JEUNEMAITRE (Xavier)</AU>
<AF>Pathologie Vasculaire et Endocrinologie Rénale, Collège de France, Chaire de Médecine Expérimentale et d'Endocrinologie Rénale, Institut National de la Santé et de la Recherche Médicale U36, 3, rue d'Ulm/75005 Paris/France (1 aut., 5 aut., 6 aut.); Equipe "phylogénie et évolution moléculaires," UPRESA CNRS 8080, Bâtiment 444, Université Paris-Sud/91405 Orsay/France (2 aut.); Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne/Parkville, Victoria 3052/Australie (3 aut.); Centre International de Recherche Médicale, BP 769/Franceville/Gabon (4 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Genomics : (San Diego, CA); ISSN 0888-7543; Etats-Unis; Da. 2000; Vol. 69; No. 1; Pp. 14-26; Bibl. 1 p.1/4</SO>
<LA>Anglais</LA>
<EA>The renin angiotensin system (RAS) is involved in blood pressure control and water/sodium metabolism. The genes encoding the proteins of this system are candidate genes for essential hypertension. The RAS involves four main molecules: angiotensinogen, renin, angiotensin I-converting enzyme, and the angiotensin II type 1 receptor (encoded by the genes AGT, REN, DCP1, and AGTR1, respectively). We performed a molecular screening over 17,037 bp of the coding and 5' and 3' untranslated regions of these genes, from three to six common chimpanzees. We identified 44 single-nucleotide polymorphisms (SNPs) in chimpanzee samples, including 18 coding-region SNPs, 5 of which led to an amino acid replacement. We observed common and different features at various sites (synonymous, nonsynonymous, and noncoding) within and between the four chimpanzee genes: (1) the nucleotide diversity at noncoding sites was similar; (2) the nucleotide diversity at nonsynonymous sites was low, probably reflecting purifying selection, except for the AGT gene; (3) the nucleotide diversity at synonymous sites, which was dependent on the G+C content at the third position of the codon, was high, except for the AGTR1 gene. Comparison of the chimpanzee SNPs with those previously reported for humans identified 119 sites with fixed differences (including 62 coding sites, 17 of which resulted in amino acid differences between the species). Analysis of polymorphism within species and divergence between species shed light on the evolutionary constraints on these genes. In particular, comparison of the pattern of mutation at polymorphic and fixed sites between humans and chimpanzees suggested that the high G+C content of the DCP1 gene was maintained by positive selection at its silent sites. Finally, we propose 68 ancestral alleles for the human RAS genes and discuss the implications for their use in future hypertension-susceptibility association studies.</EA>
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Human-chimpanzee DNA sequence variation in the four major genes of the renin angiotensin system

Human-chimpanzee DNA sequence variation in the four major genes of the renin angiotensin system

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