AustralieFrV1, PascalFrancis, Corpus, bibRecord, 005611

Activation of adrenal preganglionic neurons during autonomic dysreflexia in the chronic spinal cord-injured rat

Identifieur interne : 005611 ( PascalFrancis/Corpus ); précédent : 005610; suivant : 005612

Activation of adrenal preganglionic neurons during autonomic dysreflexia in the chronic spinal cord-injured rat

Auteurs : Samuel Leman ; Henrique Sequeira

Source :

Autonomic neuroscience : basic & clinical [ 1566-0702 ] ; 2002.

RBID : Pascal:02-0498681

Descripteurs français

Pascal (Inist)
- Neurone préganglionnaire, Chronique, Animal, Traumatisme, Moelle épinière, Système nerveux sympathique pathologie, Rat, Dysreflexie autonome.

English descriptors

KwdEn :
- Animal, Autonomic neuropathy, Chronic, Preganglionic neuron, Rat, Spinal cord, Trauma.

Abstract

Autonomic dysreflexia (AD) occurs in a majority of high paraplegic and quadriplegic patients and is particularly characterized by a paroxysmal hypertension elicited by somatic or visceral stimuli. We have previously shown that plasma adrenaline and noradrenaline levels were significantly increased during episodes of AD in the 30-day spinal cord-injured (SCI) rats, suggesting the participation of adrenal catecholamines in the cardiovascular changes associated to AD. Thus, adrenal sympathetic preganglionic neurons (SPN) could be activated by visceral afferences leading to AD. The aim of this study was then to demonstrate whether visceral stimulation that induces AD activates adrenal SPN in chronic SCI rats. To this end, a retrograde tracer, the cholera toxin B subunit (CTB), was combined with the immunocytochemical detection of Fos protein after visceral stimulation. Chronic SCI rats received a CTB injection into the adrenal gland and, 3 days later, were stimulated by repetitive distension of the colon. Results showed that this stimulation elicited typical hypertensive episodes of AD and a significant increase in the number of double-labeled neurons (CTB/Fos immunoreactive neurons) in the thoracic spinal cord below the level of injury (T4 segment) when compared to the stimulated non-SCI rats. In conclusion, visceral stimulations in the chronic SCI rats activate adrenal SPN, which could induce release of catecholamines by the adrenal medulla. The present study brings new data on the spinal mechanisms of AD cardiovascular dysfunctions.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A08	`01`	`1`	`ENG`	`@1 Activation of adrenal preganglionic neurons during autonomic dysreflexia in the chronic spinal cord-injured rat`
A09	`01`	`1`	`ENG`	`@1 Central mechanisms of cardiovascular control - cellular, molecular and integrative aspects`
A11	`01`	`1`		`@1 LEMAN (Samuel)`
A11	`02`	`1`		`@1 SEQUEIRA (Henrique)`
A12	`01`	`1`		`@1 PILOWSKY (Paul M.) @9 ed.`
A12	`02`	`1`		`@1 GIBBINS (I.) @9 ed.`
A14	`01`			`@1 Laboratoire de Neurosciences du Comportement, SN4-1, Université de Lille 1 @2 59655, Villeneuve d'Ascq @3 FRA @Z 1 aut. @Z 2 aut.`
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A43	`01`			`@1 INIST @2 18294 @5 354000101650340210`
A44				`@0 0000 @1 © 2002 INIST-CNRS. All rights reserved.`
A45				`@0 27 ref.`
A47	`01`	`1`		`@0 02-0498681`
A60				`@1 P @2 C`
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C01	`01`		`ENG`	@0 Autonomic dysreflexia (AD) occurs in a majority of high paraplegic and quadriplegic patients and is particularly characterized by a paroxysmal hypertension elicited by somatic or visceral stimuli. We have previously shown that plasma adrenaline and noradrenaline levels were significantly increased during episodes of AD in the 30-day spinal cord-injured (SCI) rats, suggesting the participation of adrenal catecholamines in the cardiovascular changes associated to AD. Thus, adrenal sympathetic preganglionic neurons (SPN) could be activated by visceral afferences leading to AD. The aim of this study was then to demonstrate whether visceral stimulation that induces AD activates adrenal SPN in chronic SCI rats. To this end, a retrograde tracer, the cholera toxin B subunit (CTB), was combined with the immunocytochemical detection of Fos protein after visceral stimulation. Chronic SCI rats received a CTB injection into the adrenal gland and, 3 days later, were stimulated by repetitive distension of the colon. Results showed that this stimulation elicited typical hypertensive episodes of AD and a significant increase in the number of double-labeled neurons (CTB/Fos immunoreactive neurons) in the thoracic spinal cord below the level of injury (T4 segment) when compared to the stimulated non-SCI rats. In conclusion, visceral stimulations in the chronic SCI rats activate adrenal SPN, which could induce release of catecholamines by the adrenal medulla. The present study brings new data on the spinal mechanisms of AD cardiovascular dysfunctions.
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C03	`06`	`X`	`FRE`	`@0 Système nerveux sympathique pathologie @5 12`
C03	`06`	`X`	`ENG`	`@0 Autonomic neuropathy @5 12`
C03	`06`	`X`	`SPA`	`@0 Sistema nervioso simpático patología @5 12`
C03	`07`	`X`	`FRE`	`@0 Rat @5 69`
C03	`07`	`X`	`ENG`	`@0 Rat @5 69`
C03	`07`	`X`	`SPA`	`@0 Rata @5 69`
C03	`08`	`X`	`FRE`	`@0 Dysreflexie autonome @4 INC @5 81`
C07	`01`	`X`	`FRE`	`@0 Système nerveux central @5 20`
C07	`01`	`X`	`ENG`	`@0 Central nervous system @5 20`
C07	`01`	`X`	`SPA`	`@0 Sistema nervioso central @5 20`
C07	`02`	`X`	`FRE`	`@0 Système nerveux central pathologie @5 38`
C07	`02`	`X`	`ENG`	`@0 Central nervous system disease @5 38`
C07	`02`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 38`
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C07	`05`	`X`	`ENG`	`@0 Vertebrata @2 NS`
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N21				`@1 294`

A30	`01`	`1`	`ENG`	`@1 Central Mechanisms of Cardiovascular Control - Cellular, Molecular and Integrative Aspects. Meeting @3 Sydney AUS @4 2000-08-20`

Format Inist (serveur)

NO :	PASCAL 02-0498681 INIST
ET :	Activation of adrenal preganglionic neurons during autonomic dysreflexia in the chronic spinal cord-injured rat
AU :	LEMAN (Samuel); SEQUEIRA (Henrique); PILOWSKY (Paul M.); GIBBINS (I.)
AF :	Laboratoire de Neurosciences du Comportement, SN4-1, Université de Lille 1/59655, Villeneuve d'Ascq/France (1 aut., 2 aut.); Research Laboratory, Central Autonomic Neuroscience, Royal North Shore Hospital, Block 3, Ground Floor/St. Leonards 2065/Australie (1 aut.)
DT :	Publication en série; Congrès; Niveau analytique
SO :	Autonomic neuroscience : basic & clinical; ISSN 1566-0702; Pays-Bas; Da. 2002; Vol. 98; No. 1-2; Pp. 94-98; Bibl. 27 ref.
LA :	Anglais
EA :	Autonomic dysreflexia (AD) occurs in a majority of high paraplegic and quadriplegic patients and is particularly characterized by a paroxysmal hypertension elicited by somatic or visceral stimuli. We have previously shown that plasma adrenaline and noradrenaline levels were significantly increased during episodes of AD in the 30-day spinal cord-injured (SCI) rats, suggesting the participation of adrenal catecholamines in the cardiovascular changes associated to AD. Thus, adrenal sympathetic preganglionic neurons (SPN) could be activated by visceral afferences leading to AD. The aim of this study was then to demonstrate whether visceral stimulation that induces AD activates adrenal SPN in chronic SCI rats. To this end, a retrograde tracer, the cholera toxin B subunit (CTB), was combined with the immunocytochemical detection of Fos protein after visceral stimulation. Chronic SCI rats received a CTB injection into the adrenal gland and, 3 days later, were stimulated by repetitive distension of the colon. Results showed that this stimulation elicited typical hypertensive episodes of AD and a significant increase in the number of double-labeled neurons (CTB/Fos immunoreactive neurons) in the thoracic spinal cord below the level of injury (T4 segment) when compared to the stimulated non-SCI rats. In conclusion, visceral stimulations in the chronic SCI rats activate adrenal SPN, which could induce release of catecholamines by the adrenal medulla. The present study brings new data on the spinal mechanisms of AD cardiovascular dysfunctions.
CC :	002B16B
FD :	Neurone préganglionnaire; Chronique; Animal; Traumatisme; Moelle épinière; Système nerveux sympathique pathologie; Rat; Dysreflexie autonome
FG :	Système nerveux central; Système nerveux central pathologie; Rodentia; Mammalia; Vertebrata
ED :	Preganglionic neuron; Chronic; Animal; Trauma; Spinal cord; Autonomic neuropathy; Rat
EG :	Central nervous system; Central nervous system disease; Rodentia; Mammalia; Vertebrata
SD :	Neurona preganglionar; Crónico; Animal; Traumatismo; Médula espinal; Sistema nervioso simpático patología; Rata
LO :	INIST-18294.354000101650340210
ID :	02-0498681

Links to Exploration step

Pascal:02-0498681

Le document en format XML

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<front><div type="abstract" xml:lang="en">Autonomic dysreflexia (AD) occurs in a majority of high paraplegic and quadriplegic patients and is particularly characterized by a paroxysmal hypertension elicited by somatic or visceral stimuli. We have previously shown that plasma adrenaline and noradrenaline levels were significantly increased during episodes of AD in the 30-day spinal cord-injured (SCI) rats, suggesting the participation of adrenal catecholamines in the cardiovascular changes associated to AD. Thus, adrenal sympathetic preganglionic neurons (SPN) could be activated by visceral afferences leading to AD. The aim of this study was then to demonstrate whether visceral stimulation that induces AD activates adrenal SPN in chronic SCI rats. To this end, a retrograde tracer, the cholera toxin B subunit (CTB), was combined with the immunocytochemical detection of Fos protein after visceral stimulation. Chronic SCI rats received a CTB injection into the adrenal gland and, 3 days later, were stimulated by repetitive distension of the colon. Results showed that this stimulation elicited typical hypertensive episodes of AD and a significant increase in the number of double-labeled neurons (CTB/Fos immunoreactive neurons) in the thoracic spinal cord below the level of injury (T4 segment) when compared to the stimulated non-SCI rats. In conclusion, visceral stimulations in the chronic SCI rats activate adrenal SPN, which could induce release of catecholamines by the adrenal medulla. The present study brings new data on the spinal mechanisms of AD cardiovascular dysfunctions.</div>
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<s2>NS</s2>
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<fC07 i1="05" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
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<pR><fA30 i1="01" i2="1" l="ENG"><s1>Central Mechanisms of Cardiovascular Control - Cellular, Molecular and Integrative Aspects. Meeting</s1>
<s3>Sydney AUS</s3>
<s4>2000-08-20</s4>
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<server><NO>PASCAL 02-0498681 INIST</NO>
<ET>Activation of adrenal preganglionic neurons during autonomic dysreflexia in the chronic spinal cord-injured rat</ET>
<AU>LEMAN (Samuel); SEQUEIRA (Henrique); PILOWSKY (Paul M.); GIBBINS (I.)</AU>
<AF>Laboratoire de Neurosciences du Comportement, SN4-1, Université de Lille 1/59655, Villeneuve d'Ascq/France (1 aut., 2 aut.); Research Laboratory, Central Autonomic Neuroscience, Royal North Shore Hospital, Block 3, Ground Floor/St. Leonards 2065/Australie (1 aut.)</AF>
<DT>Publication en série; Congrès; Niveau analytique</DT>
<SO>Autonomic neuroscience : basic & clinical; ISSN 1566-0702; Pays-Bas; Da. 2002; Vol. 98; No. 1-2; Pp. 94-98; Bibl. 27 ref.</SO>
<LA>Anglais</LA>
<EA>Autonomic dysreflexia (AD) occurs in a majority of high paraplegic and quadriplegic patients and is particularly characterized by a paroxysmal hypertension elicited by somatic or visceral stimuli. We have previously shown that plasma adrenaline and noradrenaline levels were significantly increased during episodes of AD in the 30-day spinal cord-injured (SCI) rats, suggesting the participation of adrenal catecholamines in the cardiovascular changes associated to AD. Thus, adrenal sympathetic preganglionic neurons (SPN) could be activated by visceral afferences leading to AD. The aim of this study was then to demonstrate whether visceral stimulation that induces AD activates adrenal SPN in chronic SCI rats. To this end, a retrograde tracer, the cholera toxin B subunit (CTB), was combined with the immunocytochemical detection of Fos protein after visceral stimulation. Chronic SCI rats received a CTB injection into the adrenal gland and, 3 days later, were stimulated by repetitive distension of the colon. Results showed that this stimulation elicited typical hypertensive episodes of AD and a significant increase in the number of double-labeled neurons (CTB/Fos immunoreactive neurons) in the thoracic spinal cord below the level of injury (T4 segment) when compared to the stimulated non-SCI rats. In conclusion, visceral stimulations in the chronic SCI rats activate adrenal SPN, which could induce release of catecholamines by the adrenal medulla. The present study brings new data on the spinal mechanisms of AD cardiovascular dysfunctions.</EA>
<CC>002B16B</CC>
<FD>Neurone préganglionnaire; Chronique; Animal; Traumatisme; Moelle épinière; Système nerveux sympathique pathologie; Rat; Dysreflexie autonome</FD>
<FG>Système nerveux central; Système nerveux central pathologie; Rodentia; Mammalia; Vertebrata</FG>
<ED>Preganglionic neuron; Chronic; Animal; Trauma; Spinal cord; Autonomic neuropathy; Rat</ED>
<EG>Central nervous system; Central nervous system disease; Rodentia; Mammalia; Vertebrata</EG>
<SD>Neurona preganglionar; Crónico; Animal; Traumatismo; Médula espinal; Sistema nervioso simpático patología; Rata</SD>
<LO>INIST-18294.354000101650340210</LO>
<ID>02-0498681</ID>
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Activation of adrenal preganglionic neurons during autonomic dysreflexia in the chronic spinal cord-injured rat

Activation of adrenal preganglionic neurons during autonomic dysreflexia in the chronic spinal cord-injured rat

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