AustralieFrV1, PascalFrancis, Corpus, bibRecord, 004B64

Geographical patterns and time trends of cancer incidence and survival among children and adolescents in Europe since the 1970s (the ACCIS project): an epidemiological study. Commentary

Identifieur interne : 004B64 ( PascalFrancis/Corpus ); précédent : 004B63; suivant : 004B65

Geographical patterns and time trends of cancer incidence and survival among children and adolescents in Europe since the 1970s (the ACCIS project): an epidemiological study. Commentary

Auteurs : Eva Steliarova-Foucher ; Charles Stiller ; Peter Kaatsch ; Franco Berrino ; Jan-Willem Coebergh ; Brigitte Lacour ; Max Parkin ; Catherine Cole

Source :

Lancet : (British edition) [ 0140-6736 ] ; 2004.

RBID : Pascal:05-0028657

Descripteurs français

Pascal (Inist)
- Tumeur maligne, Tendance, Incidence, Epidémiologie, Survie, Enfant, Adolescent, Europe, Santé publique, Etude critique, Médecine.

English descriptors

KwdEn :
- Adolescent, Child, Critical study, Epidemiology, Europe, Incidence, Malignant tumor, Medicine, Public health, Survival, Trend.

Abstract

Background Cancer is rare before age 20 years. We aimed to use the European database of childhood and adolescent cancer cases, within the Automated Childhood Cancer Information System project, to estimate patterns and trends of incidence and survival within Europe. Methods Comparable, high-quality data from 63 European population-based cancer registries consisted of 113 000 tumours in children and 18 243 in adolescents diagnosed in 1970-99. Incidence rates and survival were compared by region (east vs west), period, and malignant disease. Findings In the 1990s, age-standardised incidence rates were 140 per million for children (0-14 years) and 157 per million for ages 0-19 years. Over the three decades, overall incidence increased by 1.0% per year (p<0.0001) in children (increases for most tumour types), and by 1.5% (p<0.0001) in adolescents (15-19 years; notable increases were recorded for carcinomas, lymphomas, and germ-cell tumours). Overall 5-year survival for children in the 1990s was 64% in the east and 75% in the west, with differences between regions for virtually all tumour groups; 5-year survival was much the same in adolescents. Survival has improved dramatically since the 1970s in children and adolescents, more so in the west than in the east. Interpretation Our results are clear evidence of an increase of cancer incidence in childhood and adolescence during the past decades, and of an acceleration of this trend. Geographical and temporal patterns suggest areas for further study into causes of these neoplasms, as well as providing an indicator of progress of public-health policy in Europe.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0140-6736`
A02	`01`			`@0 LANCAO`
A03		`1`		`@0 Lancet : (Br. ed.)`
A05				`@2 364`
A06				`@2 9451`
A08	`01`	`1`	`ENG`	`@1 Geographical patterns and time trends of cancer incidence and survival among children and adolescents in Europe since the 1970s (the ACCIS project): an epidemiological study. Commentary`
A11	`01`	`1`		`@1 STELIAROVA-FOUCHER (Eva)`
A11	`02`	`1`		`@1 STILLER (Charles)`
A11	`03`	`1`		`@1 KAATSCH (Peter)`
A11	`04`	`1`		`@1 BERRINO (Franco)`
A11	`05`	`1`		`@1 COEBERGH (Jan-Willem)`
A11	`06`	`1`		`@1 LACOUR (Brigitte)`
A11	`07`	`1`		`@1 PARKIN (Max)`
A11	`08`	`1`		`@1 COLE (Catherine) @9 comment.`
A14	`01`			`@1 International Agency for Research on Cancer @2 Lyon @3 FRA @Z 1 aut. @Z 7 aut.`
A14	`02`			`@1 Childhood Cancer Research Group, University of Oxford @2 Oxford @3 GBR @Z 2 aut.`
A14	`03`			`@1 German Childhood Cancer Registry, University of Johannes Gutenberg @2 Mainz @3 DEU @Z 3 aut.`
A14	`04`			`@1 National Cancer Institute @2 Milan @3 ITA @Z 4 aut.`
A14	`05`			`@1 Dutch Childhood Oncology Group, The Hague, and Department of Public Health, Erasmus University @2 Rotterdam @3 NLD @Z 5 aut.`
A14	`06`			`@1 French National Registry of Childhood Solid Tumours, Faculty of Medicine @2 Vandoeuvre @3 FRA @Z 6 aut.`
A14	`07`			`@1 Department of Paediatric Haematology/Oncology, Princess Margaret Hospital for Children @2 Perth, WA 6001 @3 AUS @Z 8 aut.`
A20				`@2 2074-2076,2097-2105 [12 p.]`
A21				`@1 2004`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 5004 @5 354000122845440120`
A44				`@0 0000 @1 © 2005 INIST-CNRS. All rights reserved.`
A45				`@0 45 ref.`
A47	`01`	`1`		`@0 05-0028657`
A60				`@1 P @3 AR @3 CT`
A61				`@0 A`
A64	`01`	`1`		`@0 Lancet : (British edition)`
A66	`01`			`@0 GBR`
C01	`01`		`ENG`	@0 Background Cancer is rare before age 20 years. We aimed to use the European database of childhood and adolescent cancer cases, within the Automated Childhood Cancer Information System project, to estimate patterns and trends of incidence and survival within Europe. Methods Comparable, high-quality data from 63 European population-based cancer registries consisted of 113 000 tumours in children and 18 243 in adolescents diagnosed in 1970-99. Incidence rates and survival were compared by region (east vs west), period, and malignant disease. Findings In the 1990s, age-standardised incidence rates were 140 per million for children (0-14 years) and 157 per million for ages 0-19 years. Over the three decades, overall incidence increased by 1.0% per year (p<0.0001) in children (increases for most tumour types), and by 1.5% (p<0.0001) in adolescents (15-19 years; notable increases were recorded for carcinomas, lymphomas, and germ-cell tumours). Overall 5-year survival for children in the 1990s was 64% in the east and 75% in the west, with differences between regions for virtually all tumour groups; 5-year survival was much the same in adolescents. Survival has improved dramatically since the 1970s in children and adolescents, more so in the west than in the east. Interpretation Our results are clear evidence of an increase of cancer incidence in childhood and adolescence during the past decades, and of an acceleration of this trend. Geographical and temporal patterns suggest areas for further study into causes of these neoplasms, as well as providing an indicator of progress of public-health policy in Europe.
C02	`01`	`X`		`@0 002B01`
C03	`01`	`X`	`FRE`	`@0 Tumeur maligne @5 01`
C03	`01`	`X`	`ENG`	`@0 Malignant tumor @5 01`
C03	`01`	`X`	`SPA`	`@0 Tumor maligno @5 01`
C03	`02`	`X`	`FRE`	`@0 Tendance @5 02`
C03	`02`	`X`	`ENG`	`@0 Trend @5 02`
C03	`02`	`X`	`SPA`	`@0 Tendencia @5 02`
C03	`03`	`X`	`FRE`	`@0 Incidence @5 03`
C03	`03`	`X`	`ENG`	`@0 Incidence @5 03`
C03	`03`	`X`	`SPA`	`@0 Incidencia @5 03`
C03	`04`	`X`	`FRE`	`@0 Epidémiologie @5 05`
C03	`04`	`X`	`ENG`	`@0 Epidemiology @5 05`
C03	`04`	`X`	`SPA`	`@0 Epidemiología @5 05`
C03	`05`	`X`	`FRE`	`@0 Survie @5 06`
C03	`05`	`X`	`ENG`	`@0 Survival @5 06`
C03	`05`	`X`	`SPA`	`@0 Sobrevivencia @5 06`
C03	`06`	`X`	`FRE`	`@0 Enfant @5 08`
C03	`06`	`X`	`ENG`	`@0 Child @5 08`
C03	`06`	`X`	`SPA`	`@0 Niño @5 08`
C03	`07`	`X`	`FRE`	`@0 Adolescent @5 09`
C03	`07`	`X`	`ENG`	`@0 Adolescent @5 09`
C03	`07`	`X`	`SPA`	`@0 Adolescente @5 09`
C03	`08`	`X`	`FRE`	`@0 Europe @2 NG @5 11`
C03	`08`	`X`	`ENG`	`@0 Europe @2 NG @5 11`
C03	`08`	`X`	`SPA`	`@0 Europa @2 NG @5 11`
C03	`09`	`X`	`FRE`	`@0 Santé publique @5 12`
C03	`09`	`X`	`ENG`	`@0 Public health @5 12`
C03	`09`	`X`	`SPA`	`@0 Salud pública @5 12`
C03	`10`	`X`	`FRE`	`@0 Etude critique @5 17`
C03	`10`	`X`	`ENG`	`@0 Critical study @5 17`
C03	`10`	`X`	`SPA`	`@0 Estudio crítico @5 17`
C03	`11`	`X`	`FRE`	`@0 Médecine @5 18`
C03	`11`	`X`	`ENG`	`@0 Medicine @5 18`
C03	`11`	`X`	`SPA`	`@0 Medicina @5 18`
C07	`01`	`X`	`FRE`	`@0 Homme`
C07	`01`	`X`	`ENG`	`@0 Human`
C07	`01`	`X`	`SPA`	`@0 Hombre`
N21				`@1 010`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 05-0028657 INIST
ET :	Geographical patterns and time trends of cancer incidence and survival among children and adolescents in Europe since the 1970s (the ACCIS project): an epidemiological study. Commentary
AU :	STELIAROVA-FOUCHER (Eva); STILLER (Charles); KAATSCH (Peter); BERRINO (Franco); COEBERGH (Jan-Willem); LACOUR (Brigitte); PARKIN (Max); COLE (Catherine)
AF :	International Agency for Research on Cancer/Lyon/France (1 aut., 7 aut.); Childhood Cancer Research Group, University of Oxford/Oxford/Royaume-Uni (2 aut.); German Childhood Cancer Registry, University of Johannes Gutenberg/Mainz/Allemagne (3 aut.); National Cancer Institute/Milan/Italie (4 aut.); Dutch Childhood Oncology Group, The Hague, and Department of Public Health, Erasmus University/Rotterdam/Pays-Bas (5 aut.); French National Registry of Childhood Solid Tumours, Faculty of Medicine/Vandoeuvre/France (6 aut.); Department of Paediatric Haematology/Oncology, Princess Margaret Hospital for Children/Perth, WA 6001/Australie (8 aut.)
DT :	Publication en série; Article; Commentaire; Niveau analytique
SO :	Lancet : (British edition); ISSN 0140-6736; Coden LANCAO; Royaume-Uni; Da. 2004; Vol. 364; No. 9451; 2074-2076,2097-2105 [12 p.]; Bibl. 45 ref.
LA :	Anglais
EA :	Background Cancer is rare before age 20 years. We aimed to use the European database of childhood and adolescent cancer cases, within the Automated Childhood Cancer Information System project, to estimate patterns and trends of incidence and survival within Europe. Methods Comparable, high-quality data from 63 European population-based cancer registries consisted of 113 000 tumours in children and 18 243 in adolescents diagnosed in 1970-99. Incidence rates and survival were compared by region (east vs west), period, and malignant disease. Findings In the 1990s, age-standardised incidence rates were 140 per million for children (0-14 years) and 157 per million for ages 0-19 years. Over the three decades, overall incidence increased by 1.0% per year (p<0.0001) in children (increases for most tumour types), and by 1.5% (p<0.0001) in adolescents (15-19 years; notable increases were recorded for carcinomas, lymphomas, and germ-cell tumours). Overall 5-year survival for children in the 1990s was 64% in the east and 75% in the west, with differences between regions for virtually all tumour groups; 5-year survival was much the same in adolescents. Survival has improved dramatically since the 1970s in children and adolescents, more so in the west than in the east. Interpretation Our results are clear evidence of an increase of cancer incidence in childhood and adolescence during the past decades, and of an acceleration of this trend. Geographical and temporal patterns suggest areas for further study into causes of these neoplasms, as well as providing an indicator of progress of public-health policy in Europe.
CC :	002B01
FD :	Tumeur maligne; Tendance; Incidence; Epidémiologie; Survie; Enfant; Adolescent; Europe; Santé publique; Etude critique; Médecine
FG :	Homme
ED :	Malignant tumor; Trend; Incidence; Epidemiology; Survival; Child; Adolescent; Europe; Public health; Critical study; Medicine
EG :	Human
SD :	Tumor maligno; Tendencia; Incidencia; Epidemiología; Sobrevivencia; Niño; Adolescente; Europa; Salud pública; Estudio crítico; Medicina
LO :	INIST-5004.354000122845440120
ID :	05-0028657

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Pascal:05-0028657

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
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<front><div type="abstract" xml:lang="en">Background Cancer is rare before age 20 years. We aimed to use the European database of childhood and adolescent cancer cases, within the Automated Childhood Cancer Information System project, to estimate patterns and trends of incidence and survival within Europe. Methods Comparable, high-quality data from 63 European population-based cancer registries consisted of 113 000 tumours in children and 18 243 in adolescents diagnosed in 1970-99. Incidence rates and survival were compared by region (east vs west), period, and malignant disease. Findings In the 1990s, age-standardised incidence rates were 140 per million for children (0-14 years) and 157 per million for ages 0-19 years. Over the three decades, overall incidence increased by 1.0% per year (p<0.0001) in children (increases for most tumour types), and by 1.5% (p<0.0001) in adolescents (15-19 years; notable increases were recorded for carcinomas, lymphomas, and germ-cell tumours). Overall 5-year survival for children in the 1990s was 64% in the east and 75% in the west, with differences between regions for virtually all tumour groups; 5-year survival was much the same in adolescents. Survival has improved dramatically since the 1970s in children and adolescents, more so in the west than in the east. Interpretation Our results are clear evidence of an increase of cancer incidence in childhood and adolescence during the past decades, and of an acceleration of this trend. Geographical and temporal patterns suggest areas for further study into causes of these neoplasms, as well as providing an indicator of progress of public-health policy in Europe.</div>
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<s3>FRA</s3>
<sZ>1 aut.</sZ>
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</fA14>
<fA14 i1="02"><s1>Childhood Cancer Research Group, University of Oxford</s1>
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<s3>GBR</s3>
<sZ>2 aut.</sZ>
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<fA14 i1="03"><s1>German Childhood Cancer Registry, University of Johannes Gutenberg</s1>
<s2>Mainz</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>National Cancer Institute</s1>
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<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Dutch Childhood Oncology Group, The Hague, and Department of Public Health, Erasmus University</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>French National Registry of Childhood Solid Tumours, Faculty of Medicine</s1>
<s2>Vandoeuvre</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>Department of Paediatric Haematology/Oncology, Princess Margaret Hospital for Children</s1>
<s2>Perth, WA 6001</s2>
<s3>AUS</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA20><s2>2074-2076,2097-2105 [12 p.]</s2>
</fA20>
<fA21><s1>2004</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>5004</s2>
<s5>354000122845440120</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2005 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>45 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>05-0028657</s0>
</fA47>
<fA60><s1>P</s1>
<s3>AR</s3>
<s3>CT</s3>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Lancet : (British edition)</s0>
</fA64>
<fA66 i1="01"><s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Background Cancer is rare before age 20 years. We aimed to use the European database of childhood and adolescent cancer cases, within the Automated Childhood Cancer Information System project, to estimate patterns and trends of incidence and survival within Europe. Methods Comparable, high-quality data from 63 European population-based cancer registries consisted of 113 000 tumours in children and 18 243 in adolescents diagnosed in 1970-99. Incidence rates and survival were compared by region (east vs west), period, and malignant disease. Findings In the 1990s, age-standardised incidence rates were 140 per million for children (0-14 years) and 157 per million for ages 0-19 years. Over the three decades, overall incidence increased by 1.0% per year (p<0.0001) in children (increases for most tumour types), and by 1.5% (p<0.0001) in adolescents (15-19 years; notable increases were recorded for carcinomas, lymphomas, and germ-cell tumours). Overall 5-year survival for children in the 1990s was 64% in the east and 75% in the west, with differences between regions for virtually all tumour groups; 5-year survival was much the same in adolescents. Survival has improved dramatically since the 1970s in children and adolescents, more so in the west than in the east. Interpretation Our results are clear evidence of an increase of cancer incidence in childhood and adolescence during the past decades, and of an acceleration of this trend. Geographical and temporal patterns suggest areas for further study into causes of these neoplasms, as well as providing an indicator of progress of public-health policy in Europe.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B01</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Tumeur maligne</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Malignant tumor</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Tumor maligno</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Tendance</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Trend</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Tendencia</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Incidence</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Incidence</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Incidencia</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Epidémiologie</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Epidemiology</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Epidemiología</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Survie</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Survival</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Sobrevivencia</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Enfant</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Child</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Niño</s0>
<s5>08</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Adolescent</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Adolescent</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Adolescente</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Europe</s0>
<s2>NG</s2>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Europe</s0>
<s2>NG</s2>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Europa</s0>
<s2>NG</s2>
<s5>11</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Santé publique</s0>
<s5>12</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Public health</s0>
<s5>12</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Salud pública</s0>
<s5>12</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Etude critique</s0>
<s5>17</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Critical study</s0>
<s5>17</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Estudio crítico</s0>
<s5>17</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Médecine</s0>
<s5>18</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Medicine</s0>
<s5>18</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Medicina</s0>
<s5>18</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Homme</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Human</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Hombre</s0>
</fC07>
<fN21><s1>010</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
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<server><NO>PASCAL 05-0028657 INIST</NO>
<ET>Geographical patterns and time trends of cancer incidence and survival among children and adolescents in Europe since the 1970s (the ACCIS project): an epidemiological study. Commentary</ET>
<AU>STELIAROVA-FOUCHER (Eva); STILLER (Charles); KAATSCH (Peter); BERRINO (Franco); COEBERGH (Jan-Willem); LACOUR (Brigitte); PARKIN (Max); COLE (Catherine)</AU>
<AF>International Agency for Research on Cancer/Lyon/France (1 aut., 7 aut.); Childhood Cancer Research Group, University of Oxford/Oxford/Royaume-Uni (2 aut.); German Childhood Cancer Registry, University of Johannes Gutenberg/Mainz/Allemagne (3 aut.); National Cancer Institute/Milan/Italie (4 aut.); Dutch Childhood Oncology Group, The Hague, and Department of Public Health, Erasmus University/Rotterdam/Pays-Bas (5 aut.); French National Registry of Childhood Solid Tumours, Faculty of Medicine/Vandoeuvre/France (6 aut.); Department of Paediatric Haematology/Oncology, Princess Margaret Hospital for Children/Perth, WA 6001/Australie (8 aut.)</AF>
<DT>Publication en série; Article; Commentaire; Niveau analytique</DT>
<SO>Lancet : (British edition); ISSN 0140-6736; Coden LANCAO; Royaume-Uni; Da. 2004; Vol. 364; No. 9451; 2074-2076,2097-2105 [12 p.]; Bibl. 45 ref.</SO>
<LA>Anglais</LA>
<EA>Background Cancer is rare before age 20 years. We aimed to use the European database of childhood and adolescent cancer cases, within the Automated Childhood Cancer Information System project, to estimate patterns and trends of incidence and survival within Europe. Methods Comparable, high-quality data from 63 European population-based cancer registries consisted of 113 000 tumours in children and 18 243 in adolescents diagnosed in 1970-99. Incidence rates and survival were compared by region (east vs west), period, and malignant disease. Findings In the 1990s, age-standardised incidence rates were 140 per million for children (0-14 years) and 157 per million for ages 0-19 years. Over the three decades, overall incidence increased by 1.0% per year (p<0.0001) in children (increases for most tumour types), and by 1.5% (p<0.0001) in adolescents (15-19 years; notable increases were recorded for carcinomas, lymphomas, and germ-cell tumours). Overall 5-year survival for children in the 1990s was 64% in the east and 75% in the west, with differences between regions for virtually all tumour groups; 5-year survival was much the same in adolescents. Survival has improved dramatically since the 1970s in children and adolescents, more so in the west than in the east. Interpretation Our results are clear evidence of an increase of cancer incidence in childhood and adolescence during the past decades, and of an acceleration of this trend. Geographical and temporal patterns suggest areas for further study into causes of these neoplasms, as well as providing an indicator of progress of public-health policy in Europe.</EA>
<CC>002B01</CC>
<FD>Tumeur maligne; Tendance; Incidence; Epidémiologie; Survie; Enfant; Adolescent; Europe; Santé publique; Etude critique; Médecine</FD>
<FG>Homme</FG>
<ED>Malignant tumor; Trend; Incidence; Epidemiology; Survival; Child; Adolescent; Europe; Public health; Critical study; Medicine</ED>
<EG>Human</EG>
<SD>Tumor maligno; Tendencia; Incidencia; Epidemiología; Sobrevivencia; Niño; Adolescente; Europa; Salud pública; Estudio crítico; Medicina</SD>
<LO>INIST-5004.354000122845440120</LO>
<ID>05-0028657</ID>
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Geographical patterns and time trends of cancer incidence and survival among children and adolescents in Europe since the 1970s (the ACCIS project): an epidemiological study. Commentary

Geographical patterns and time trends of cancer incidence and survival among children and adolescents in Europe since the 1970s (the ACCIS project): an epidemiological study. Commentary

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