Genomewide linkage scan of 409 European-ancestry and African American families with schizophrenia : Suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sample
Identifieur interne : 004126 ( PascalFrancis/Corpus ); précédent : 004125; suivant : 004127Genomewide linkage scan of 409 European-ancestry and African American families with schizophrenia : Suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sample
Auteurs : Brian K. Suarez ; Jubao Duan ; Alan R. Sanders ; Anthony L. Hinrichs ; Carol H. Jin ; CUIPING HOU ; Nancy G. Buccola ; Nancy Hale ; Ann N. Weilbaecher ; Deborah A. Nertney ; Ann Olincy ; Susan Green ; Arthur W. Schaffer ; Christopher J. Smith ; Dominique E. Hannah ; John P. Rice ; Nancy J. Cox ; Maria Martinez ; Bryan J. Mowry ; Farooq Amin ; Jeremy M. Silverman ; Donald W. Black ; William F. Byerley ; Raymond R. Crowe ; Robert Freedman ; C. Robert Cloninger ; Douglas F. Levinson ; Pablo V. GejmanSource :
- American journal of human genetics [ 0002-9297 ] ; 2006.
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English descriptors
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Abstract
We report the clinical characteristics of a schizophrenia sample of 409 pedigrees-263 of European ancestry (EA) and 146 of African American ancestry (AA)-together with the results of a genome scan (with a simple tandem repeat polymorphism interval of 9 cM) and follow-up fine mapping. A family was required to have a proband with schizophrenia (SZ) and one or more siblings of the proband with SZ or schizoaffective disorder. Linkage analyses included 403 independent full-sibling affected sibling pairs (ASPs) (279 EA and 124 AA) and 100 all-possible half-sibling ASPs (15 EA and 85 AA). Nonparametric multipoint linkage analysis of all families detected two regions with suggestive evidence of linkage at 8p23.3-q12 and llpll.2-q22.3 (empirical Z likelihood-ratio score [Zlr] threshold ≥2.65) and, in exploratory analyses, two other regions at 4p16.1-p15.32 in AA families and at 5p14.3-q11.2 in EA families. The most significant linkage peak was in chromosome 8p; its signal was mainly driven by the EA families. Zlr scores >2.0 in 8p were observed from 30.7 cM to 61.7 cM (Center for Inherited Disease Research map locations). The maximum evidence in the full sample was a multipoint Zlr of 3.25 (equivalent Kong-Cox LOD of 2.30) near D8S1771 (at 52 cM); there appeared to be two peaks, both telomeric to neuregulin 1 (NRG1). There is a paracentric inversion common in EA individuals within this region, the effect of which on the linkage evidence remains unknown in this and in other previously analyzed samples. Fine mapping of 8p did not significantly alter the significance or length of the peak. We also performed fine mapping of 4p16.3-p15.2, 5p15.2-q13.3, 10p15.3-p14, 10q25.3-q26.3, and 11p13-q23.3. The highest increase in Zlr scores was observed for 5p14.1-q12.1, where the maximum Zlr increased from 2.77 initially to 3.80 after fine mapping in the EA families.
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| NO : | PASCAL 06-0468036 INIST |
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| ET : | Genomewide linkage scan of 409 European-ancestry and African American families with schizophrenia : Suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sample |
| AU : | SUAREZ (Brian K.); DUAN (Jubao); SANDERS (Alan R.); HINRICHS (Anthony L.); JIN (Carol H.); CUIPING HOU; BUCCOLA (Nancy G.); HALE (Nancy); WEILBAECHER (Ann N.); NERTNEY (Deborah A.); OLINCY (Ann); GREEN (Susan); SCHAFFER (Arthur W.); SMITH (Christopher J.); HANNAH (Dominique E.); RICE (John P.); COX (Nancy J.); MARTINEZ (Maria); MOWRY (Bryan J.); AMIN (Farooq); SILVERMAN (Jeremy M.); BLACK (Donald W.); BYERLEY (William F.); CROWE (Raymond R.); FREEDMAN (Robert); CLONINGER (C. Robert); LEVINSON (Douglas F.); GEJMAN (Pablo V.) |
| AF : | Departments of Psychiatry and Genetics, Washington University/St. Louis/Etats-Unis (1 aut., 4 aut., 5 aut., 13 aut., 16 aut., 26 aut.); Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University/Evanston, IL/Etats-Unis (2 aut., 3 aut., 6 aut., 18 aut., 28 aut.); School of Nursing, Louisiana State University Health Sciences Center/New Orleans/Etats-Unis (7 aut.); Mental Health Clinical Research Center and Department of Psychiatry, University of Iowa College of Medicine/Iowa City/Etats-Unis (8 aut., 22 aut., 24 aut.); Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University/Etats-Unis (9 aut.); Queensland Centre for Schizophrenia Mental Health Research, The Park, Centre for Mental Health/Wacol/Australie (10 aut., 15 aut., 19 aut.); Department of Psychiatry, University of Queensland/Brisbane/Australie (10 aut., 15 aut., 19 aut.); Department of Psychiatry and Colorado Psychiatric Health, University of Colorado School of Medicine/Denver/Etats-Unis (11 aut., 25 aut.); Atlanta VA Medical Center and Department of Psychiatry and Behavioral Sciences, Emory University/Atlanta/Etats-Unis (12 aut., 20 aut.); Department of Psychiatry, Mount Sinai School of Medicine/New York/Etats-Unis (14 aut., 21 aut.); Department of Medicine, University of Chicago/Chicago/Etats-Unis (17 aut.); Méthodologie Statistique et Epidémiologie Génétique des Maladies Multifactorielles, Institut National de la Recherche et de la Santé Médicale/Evry/France (18 aut.); Baylor College of Medicine/Houston/Etats-Unis (20 aut.); Department of Psychiatry, University of California at Irvine/Irvine/Etats-Unis (23 aut.); Department of Psychiatry, University of California-San Francisco/San Francisco/Etats-Unis (23 aut.); Department of Psychiatry, University of Pennsylvania/Philadelphia/Etats-Unis (27 aut.) |
| DT : | Publication en série; Niveau analytique |
| SO : | American journal of human genetics; ISSN 0002-9297; Coden AJHGAG; Etats-Unis; Da. 2006; Vol. 78; No. 2; Pp. 315-333; Bibl. 2 p.1/4 |
| LA : | Anglais |
| EA : | We report the clinical characteristics of a schizophrenia sample of 409 pedigrees-263 of European ancestry (EA) and 146 of African American ancestry (AA)-together with the results of a genome scan (with a simple tandem repeat polymorphism interval of 9 cM) and follow-up fine mapping. A family was required to have a proband with schizophrenia (SZ) and one or more siblings of the proband with SZ or schizoaffective disorder. Linkage analyses included 403 independent full-sibling affected sibling pairs (ASPs) (279 EA and 124 AA) and 100 all-possible half-sibling ASPs (15 EA and 85 AA). Nonparametric multipoint linkage analysis of all families detected two regions with suggestive evidence of linkage at 8p23.3-q12 and llpll.2-q22.3 (empirical Z likelihood-ratio score [Zlr] threshold ≥2.65) and, in exploratory analyses, two other regions at 4p16.1-p15.32 in AA families and at 5p14.3-q11.2 in EA families. The most significant linkage peak was in chromosome 8p; its signal was mainly driven by the EA families. Zlr scores >2.0 in 8p were observed from 30.7 cM to 61.7 cM (Center for Inherited Disease Research map locations). The maximum evidence in the full sample was a multipoint Zlr of 3.25 (equivalent Kong-Cox LOD of 2.30) near D8S1771 (at 52 cM); there appeared to be two peaks, both telomeric to neuregulin 1 (NRG1). There is a paracentric inversion common in EA individuals within this region, the effect of which on the linkage evidence remains unknown in this and in other previously analyzed samples. Fine mapping of 8p did not significantly alter the significance or length of the peak. We also performed fine mapping of 4p16.3-p15.2, 5p15.2-q13.3, 10p15.3-p14, 10q25.3-q26.3, and 11p13-q23.3. The highest increase in Zlr scores was observed for 5p14.1-q12.1, where the maximum Zlr increased from 2.77 initially to 3.80 after fine mapping in the EA families. |
| CC : | 002A04; 002A07C03; 002B23A; 002B18C06A |
| FD : | Schizophrénie; Génome; Pathogénie; Déterminisme génétique; Liaison génétique; Carte génétique; Européen; Europe; Afro Américain; Etude familiale; Gène CDKN1A; Echantillon; Génétique; Homme |
| FG : | Psychose |
| ED : | Schizophrenia; Genome; Pathogenesis; Genetic determinism; Genetic linkage; Genetic mapping; European; Europe; African American; Family study; CDKN1A Gene; Sample; Genetics; Human |
| EG : | Psychosis |
| SD : | Esquizofrenia; Genoma; Patogenia; Determinismo genético; Ligamiento genético; Mapa genético; Europeo; Europa; Afroamericano; Estudio familiar; Gen CDKN1A; Muestra; Genética; Hombre |
| LO : | INIST-2610.354000132911260120 |
| ID : | 06-0468036 |
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Pascal:06-0468036Le document en format XML
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Cox</name><affiliation><inist:fA14 i1="11"><s1>Department of Medicine, University of Chicago</s1><s2>Chicago</s2><s3>USA</s3><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Martinez, Maria" sort="Martinez, Maria" uniqKey="Martinez M" first="Maria" last="Martinez">Maria Martinez</name><affiliation><inist:fA14 i1="02"><s1>Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University</s1><s2>Evanston, IL</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>18 aut.</sZ><sZ>28 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="12"><s1>Méthodologie Statistique et Epidémiologie Génétique des Maladies Multifactorielles, Institut National de la Recherche et de la Santé Médicale</s1><s2>Evry</s2><s3>FRA</s3><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Mowry, Bryan J" sort="Mowry, Bryan J" uniqKey="Mowry B" first="Bryan J." last="Mowry">Bryan J. Mowry</name><affiliation><inist:fA14 i1="06"><s1>Queensland Centre for Schizophrenia Mental Health Research, The Park, Centre for Mental Health</s1><s2>Wacol</s2><s3>AUS</s3><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>19 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="07"><s1>Department of Psychiatry, University of Queensland</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>19 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Amin, Farooq" sort="Amin, Farooq" uniqKey="Amin F" first="Farooq" last="Amin">Farooq Amin</name><affiliation><inist:fA14 i1="09"><s1>Atlanta VA Medical Center and Department of Psychiatry and Behavioral Sciences, Emory University</s1><s2>Atlanta</s2><s3>USA</s3><sZ>12 aut.</sZ><sZ>20 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="13"><s1>Baylor College of Medicine</s1><s2>Houston</s2><s3>USA</s3><sZ>20 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Silverman, Jeremy M" sort="Silverman, Jeremy M" uniqKey="Silverman J" first="Jeremy M." last="Silverman">Jeremy M. Silverman</name><affiliation><inist:fA14 i1="10"><s1>Department of Psychiatry, Mount Sinai School of Medicine</s1><s2>New York</s2><s3>USA</s3><sZ>14 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Black, Donald W" sort="Black, Donald W" uniqKey="Black D" first="Donald W." last="Black">Donald W. Black</name><affiliation><inist:fA14 i1="04"><s1>Mental Health Clinical Research Center and Department of Psychiatry, University of Iowa College of Medicine</s1><s2>Iowa City</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>22 aut.</sZ><sZ>24 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Byerley, William F" sort="Byerley, William F" uniqKey="Byerley W" first="William F." last="Byerley">William F. Byerley</name><affiliation><inist:fA14 i1="14"><s1>Department of Psychiatry, University of California at Irvine</s1><s2>Irvine</s2><s3>USA</s3><sZ>23 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="15"><s1>Department of Psychiatry, University of California-San Francisco</s1><s2>San Francisco</s2><s3>USA</s3><sZ>23 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Crowe, Raymond R" sort="Crowe, Raymond R" uniqKey="Crowe R" first="Raymond R." last="Crowe">Raymond R. Crowe</name><affiliation><inist:fA14 i1="04"><s1>Mental Health Clinical Research Center and Department of Psychiatry, University of Iowa College of Medicine</s1><s2>Iowa City</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>22 aut.</sZ><sZ>24 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Freedman, Robert" sort="Freedman, Robert" uniqKey="Freedman R" first="Robert" last="Freedman">Robert Freedman</name><affiliation><inist:fA14 i1="08"><s1>Department of Psychiatry and Colorado Psychiatric Health, University of Colorado School of Medicine</s1><s2>Denver</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>25 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Cloninger, C Robert" sort="Cloninger, C Robert" uniqKey="Cloninger C" first="C. Robert" last="Cloninger">C. Robert Cloninger</name><affiliation><inist:fA14 i1="01"><s1>Departments of Psychiatry and Genetics, Washington University</s1><s2>St. Louis</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Levinson, Douglas F" sort="Levinson, Douglas F" uniqKey="Levinson D" first="Douglas F." last="Levinson">Douglas F. Levinson</name><affiliation><inist:fA14 i1="16"><s1>Department of Psychiatry, University of Pennsylvania</s1><s2>Philadelphia</s2><s3>USA</s3><sZ>27 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Gejman, Pablo V" sort="Gejman, Pablo V" uniqKey="Gejman P" first="Pablo V." last="Gejman">Pablo V. Gejman</name><affiliation><inist:fA14 i1="02"><s1>Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University</s1><s2>Evanston, IL</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>18 aut.</sZ><sZ>28 aut.</sZ></inist:fA14></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">06-0468036</idno><date when="2006">2006</date><idno type="stanalyst">PASCAL 06-0468036 INIST</idno><idno type="RBID">Pascal:06-0468036</idno><idno type="wicri:Area/PascalFrancis/Corpus">004126</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Genomewide linkage scan of 409 European-ancestry and African American families with schizophrenia : Suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sample</title><author><name sortKey="Suarez, Brian K" sort="Suarez, Brian K" uniqKey="Suarez B" first="Brian K." last="Suarez">Brian K. Suarez</name><affiliation><inist:fA14 i1="01"><s1>Departments of Psychiatry and Genetics, Washington University</s1><s2>St. Louis</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Duan, Jubao" sort="Duan, Jubao" uniqKey="Duan J" first="Jubao" last="Duan">Jubao Duan</name><affiliation><inist:fA14 i1="02"><s1>Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University</s1><s2>Evanston, IL</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>18 aut.</sZ><sZ>28 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Sanders, Alan R" sort="Sanders, Alan R" uniqKey="Sanders A" first="Alan R." last="Sanders">Alan R. Sanders</name><affiliation><inist:fA14 i1="02"><s1>Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University</s1><s2>Evanston, IL</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>18 aut.</sZ><sZ>28 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Hinrichs, Anthony L" sort="Hinrichs, Anthony L" uniqKey="Hinrichs A" first="Anthony L." last="Hinrichs">Anthony L. Hinrichs</name><affiliation><inist:fA14 i1="01"><s1>Departments of Psychiatry and Genetics, Washington University</s1><s2>St. Louis</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Jin, Carol H" sort="Jin, Carol H" uniqKey="Jin C" first="Carol H." last="Jin">Carol H. Jin</name><affiliation><inist:fA14 i1="01"><s1>Departments of Psychiatry and Genetics, Washington University</s1><s2>St. Louis</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Cuiping Hou" sort="Cuiping Hou" uniqKey="Cuiping Hou" last="Cuiping Hou">CUIPING HOU</name><affiliation><inist:fA14 i1="02"><s1>Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University</s1><s2>Evanston, IL</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>18 aut.</sZ><sZ>28 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Buccola, Nancy G" sort="Buccola, Nancy G" uniqKey="Buccola N" first="Nancy G." last="Buccola">Nancy G. Buccola</name><affiliation><inist:fA14 i1="03"><s1>School of Nursing, Louisiana State University Health Sciences Center</s1><s2>New Orleans</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Hale, Nancy" sort="Hale, Nancy" uniqKey="Hale N" first="Nancy" last="Hale">Nancy Hale</name><affiliation><inist:fA14 i1="04"><s1>Mental Health Clinical Research Center and Department of Psychiatry, University of Iowa College of Medicine</s1><s2>Iowa City</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>22 aut.</sZ><sZ>24 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Weilbaecher, Ann N" sort="Weilbaecher, Ann N" uniqKey="Weilbaecher A" first="Ann N." last="Weilbaecher">Ann N. Weilbaecher</name><affiliation><inist:fA14 i1="05"><s1>Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University</s1><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Nertney, Deborah A" sort="Nertney, Deborah A" uniqKey="Nertney D" first="Deborah A." last="Nertney">Deborah A. Nertney</name><affiliation><inist:fA14 i1="06"><s1>Queensland Centre for Schizophrenia Mental Health Research, The Park, Centre for Mental Health</s1><s2>Wacol</s2><s3>AUS</s3><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>19 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="07"><s1>Department of Psychiatry, University of Queensland</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>19 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Olincy, Ann" sort="Olincy, Ann" uniqKey="Olincy A" first="Ann" last="Olincy">Ann Olincy</name><affiliation><inist:fA14 i1="08"><s1>Department of Psychiatry and Colorado Psychiatric Health, University of Colorado School of Medicine</s1><s2>Denver</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>25 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Green, Susan" sort="Green, Susan" uniqKey="Green S" first="Susan" last="Green">Susan Green</name><affiliation><inist:fA14 i1="09"><s1>Atlanta VA Medical Center and Department of Psychiatry and Behavioral Sciences, Emory University</s1><s2>Atlanta</s2><s3>USA</s3><sZ>12 aut.</sZ><sZ>20 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Schaffer, Arthur W" sort="Schaffer, Arthur W" uniqKey="Schaffer A" first="Arthur W." last="Schaffer">Arthur W. Schaffer</name><affiliation><inist:fA14 i1="01"><s1>Departments of Psychiatry and Genetics, Washington University</s1><s2>St. Louis</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Smith, Christopher J" sort="Smith, Christopher J" uniqKey="Smith C" first="Christopher J." last="Smith">Christopher J. Smith</name><affiliation><inist:fA14 i1="10"><s1>Department of Psychiatry, Mount Sinai School of Medicine</s1><s2>New York</s2><s3>USA</s3><sZ>14 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Hannah, Dominique E" sort="Hannah, Dominique E" uniqKey="Hannah D" first="Dominique E." last="Hannah">Dominique E. Hannah</name><affiliation><inist:fA14 i1="06"><s1>Queensland Centre for Schizophrenia Mental Health Research, The Park, Centre for Mental Health</s1><s2>Wacol</s2><s3>AUS</s3><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>19 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="07"><s1>Department of Psychiatry, University of Queensland</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>19 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Rice, John P" sort="Rice, John P" uniqKey="Rice J" first="John P." last="Rice">John P. Rice</name><affiliation><inist:fA14 i1="01"><s1>Departments of Psychiatry and Genetics, Washington University</s1><s2>St. Louis</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Cox, Nancy J" sort="Cox, Nancy J" uniqKey="Cox N" first="Nancy J." last="Cox">Nancy J. Cox</name><affiliation><inist:fA14 i1="11"><s1>Department of Medicine, University of Chicago</s1><s2>Chicago</s2><s3>USA</s3><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Martinez, Maria" sort="Martinez, Maria" uniqKey="Martinez M" first="Maria" last="Martinez">Maria Martinez</name><affiliation><inist:fA14 i1="02"><s1>Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University</s1><s2>Evanston, IL</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>18 aut.</sZ><sZ>28 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="12"><s1>Méthodologie Statistique et Epidémiologie Génétique des Maladies Multifactorielles, Institut National de la Recherche et de la Santé Médicale</s1><s2>Evry</s2><s3>FRA</s3><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Mowry, Bryan J" sort="Mowry, Bryan J" uniqKey="Mowry B" first="Bryan J." last="Mowry">Bryan J. Mowry</name><affiliation><inist:fA14 i1="06"><s1>Queensland Centre for Schizophrenia Mental Health Research, The Park, Centre for Mental Health</s1><s2>Wacol</s2><s3>AUS</s3><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>19 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="07"><s1>Department of Psychiatry, University of Queensland</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>19 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Amin, Farooq" sort="Amin, Farooq" uniqKey="Amin F" first="Farooq" last="Amin">Farooq Amin</name><affiliation><inist:fA14 i1="09"><s1>Atlanta VA Medical Center and Department of Psychiatry and Behavioral Sciences, Emory University</s1><s2>Atlanta</s2><s3>USA</s3><sZ>12 aut.</sZ><sZ>20 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="13"><s1>Baylor College of Medicine</s1><s2>Houston</s2><s3>USA</s3><sZ>20 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Silverman, Jeremy M" sort="Silverman, Jeremy M" uniqKey="Silverman J" first="Jeremy M." last="Silverman">Jeremy M. Silverman</name><affiliation><inist:fA14 i1="10"><s1>Department of Psychiatry, Mount Sinai School of Medicine</s1><s2>New York</s2><s3>USA</s3><sZ>14 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Black, Donald W" sort="Black, Donald W" uniqKey="Black D" first="Donald W." last="Black">Donald W. Black</name><affiliation><inist:fA14 i1="04"><s1>Mental Health Clinical Research Center and Department of Psychiatry, University of Iowa College of Medicine</s1><s2>Iowa City</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>22 aut.</sZ><sZ>24 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Byerley, William F" sort="Byerley, William F" uniqKey="Byerley W" first="William F." last="Byerley">William F. Byerley</name><affiliation><inist:fA14 i1="14"><s1>Department of Psychiatry, University of California at Irvine</s1><s2>Irvine</s2><s3>USA</s3><sZ>23 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="15"><s1>Department of Psychiatry, University of California-San Francisco</s1><s2>San Francisco</s2><s3>USA</s3><sZ>23 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Crowe, Raymond R" sort="Crowe, Raymond R" uniqKey="Crowe R" first="Raymond R." last="Crowe">Raymond R. Crowe</name><affiliation><inist:fA14 i1="04"><s1>Mental Health Clinical Research Center and Department of Psychiatry, University of Iowa College of Medicine</s1><s2>Iowa City</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>22 aut.</sZ><sZ>24 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Freedman, Robert" sort="Freedman, Robert" uniqKey="Freedman R" first="Robert" last="Freedman">Robert Freedman</name><affiliation><inist:fA14 i1="08"><s1>Department of Psychiatry and Colorado Psychiatric Health, University of Colorado School of Medicine</s1><s2>Denver</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>25 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Cloninger, C Robert" sort="Cloninger, C Robert" uniqKey="Cloninger C" first="C. Robert" last="Cloninger">C. Robert Cloninger</name><affiliation><inist:fA14 i1="01"><s1>Departments of Psychiatry and Genetics, Washington University</s1><s2>St. Louis</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Levinson, Douglas F" sort="Levinson, Douglas F" uniqKey="Levinson D" first="Douglas F." last="Levinson">Douglas F. Levinson</name><affiliation><inist:fA14 i1="16"><s1>Department of Psychiatry, University of Pennsylvania</s1><s2>Philadelphia</s2><s3>USA</s3><sZ>27 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Gejman, Pablo V" sort="Gejman, Pablo V" uniqKey="Gejman P" first="Pablo V." last="Gejman">Pablo V. Gejman</name><affiliation><inist:fA14 i1="02"><s1>Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University</s1><s2>Evanston, IL</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>18 aut.</sZ><sZ>28 aut.</sZ></inist:fA14></affiliation></author></analytic><series><title level="j" type="main">American journal of human genetics</title><title level="j" type="abbreviated">Am. j. hum. genet.</title><idno type="ISSN">0002-9297</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">American journal of human genetics</title><title level="j" type="abbreviated">Am. j. hum. genet.</title><idno type="ISSN">0002-9297</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>African American</term><term>CDKN1A Gene</term><term>Europe</term><term>European</term><term>Family study</term><term>Genetic determinism</term><term>Genetic linkage</term><term>Genetic mapping</term><term>Genetics</term><term>Genome</term><term>Human</term><term>Pathogenesis</term><term>Sample</term><term>Schizophrenia</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Schizophrénie</term><term>Génome</term><term>Pathogénie</term><term>Déterminisme génétique</term><term>Liaison génétique</term><term>Carte génétique</term><term>Européen</term><term>Europe</term><term>Afro Américain</term><term>Etude familiale</term><term>Gène CDKN1A</term><term>Echantillon</term><term>Génétique</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We report the clinical characteristics of a schizophrenia sample of 409 pedigrees-263 of European ancestry (EA) and 146 of African American ancestry (AA)-together with the results of a genome scan (with a simple tandem repeat polymorphism interval of 9 cM) and follow-up fine mapping. A family was required to have a proband with schizophrenia (SZ) and one or more siblings of the proband with SZ or schizoaffective disorder. Linkage analyses included 403 independent full-sibling affected sibling pairs (ASPs) (279 EA and 124 AA) and 100 all-possible half-sibling ASPs (15 EA and 85 AA). Nonparametric multipoint linkage analysis of all families detected two regions with suggestive evidence of linkage at 8p23.3-q12 and llpll.2-q22.3 (empirical Z likelihood-ratio score [Z<sub>lr</sub>] threshold ≥2.65) and, in exploratory analyses, two other regions at 4p16.1-p15.32 in AA families and at 5p14.3-q11.2 in EA families. The most significant linkage peak was in chromosome 8p; its signal was mainly driven by the EA families. Z<sub>lr</sub> scores >2.0 in 8p were observed from 30.7 cM to 61.7 cM (Center for Inherited Disease Research map locations). The maximum evidence in the full sample was a multipoint Z<sub>lr</sub> of 3.25 (equivalent Kong-Cox LOD of 2.30) near D8S1771 (at 52 cM); there appeared to be two peaks, both telomeric to neuregulin 1 (NRG1). There is a paracentric inversion common in EA individuals within this region, the effect of which on the linkage evidence remains unknown in this and in other previously analyzed samples. Fine mapping of 8p did not significantly alter the significance or length of the peak. We also performed fine mapping of 4p16.3-p15.2, 5p15.2-q13.3, 10p15.3-p14, 10q25.3-q26.3, and 11p13-q23.3. The highest increase in Z<sub>lr</sub> scores was observed for 5p14.1-q12.1, where the maximum Z<sub>lr</sub> increased from 2.77 initially to 3.80 after fine mapping in the EA families.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0002-9297</s0></fA01><fA02 i1="01"><s0>AJHGAG</s0></fA02><fA03 i2="1"><s0>Am. j. hum. genet.</s0></fA03><fA05><s2>78</s2></fA05><fA06><s2>2</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Genomewide linkage scan of 409 European-ancestry and African American families with schizophrenia : Suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sample</s1></fA08><fA11 i1="01" i2="1"><s1>SUAREZ (Brian K.)</s1></fA11><fA11 i1="02" i2="1"><s1>DUAN (Jubao)</s1></fA11><fA11 i1="03" i2="1"><s1>SANDERS (Alan R.)</s1></fA11><fA11 i1="04" i2="1"><s1>HINRICHS (Anthony L.)</s1></fA11><fA11 i1="05" i2="1"><s1>JIN (Carol H.)</s1></fA11><fA11 i1="06" i2="1"><s1>CUIPING HOU</s1></fA11><fA11 i1="07" i2="1"><s1>BUCCOLA (Nancy G.)</s1></fA11><fA11 i1="08" i2="1"><s1>HALE (Nancy)</s1></fA11><fA11 i1="09" i2="1"><s1>WEILBAECHER (Ann N.)</s1></fA11><fA11 i1="10" i2="1"><s1>NERTNEY (Deborah A.)</s1></fA11><fA11 i1="11" i2="1"><s1>OLINCY (Ann)</s1></fA11><fA11 i1="12" i2="1"><s1>GREEN (Susan)</s1></fA11><fA11 i1="13" i2="1"><s1>SCHAFFER (Arthur W.)</s1></fA11><fA11 i1="14" i2="1"><s1>SMITH (Christopher J.)</s1></fA11><fA11 i1="15" i2="1"><s1>HANNAH (Dominique E.)</s1></fA11><fA11 i1="16" i2="1"><s1>RICE (John P.)</s1></fA11><fA11 i1="17" i2="1"><s1>COX (Nancy J.)</s1></fA11><fA11 i1="18" i2="1"><s1>MARTINEZ (Maria)</s1></fA11><fA11 i1="19" i2="1"><s1>MOWRY (Bryan J.)</s1></fA11><fA11 i1="20" i2="1"><s1>AMIN (Farooq)</s1></fA11><fA11 i1="21" i2="1"><s1>SILVERMAN (Jeremy M.)</s1></fA11><fA11 i1="22" i2="1"><s1>BLACK (Donald W.)</s1></fA11><fA11 i1="23" i2="1"><s1>BYERLEY (William F.)</s1></fA11><fA11 i1="24" i2="1"><s1>CROWE (Raymond R.)</s1></fA11><fA11 i1="25" i2="1"><s1>FREEDMAN (Robert)</s1></fA11><fA11 i1="26" i2="1"><s1>CLONINGER (C. Robert)</s1></fA11><fA11 i1="27" i2="1"><s1>LEVINSON (Douglas F.)</s1></fA11><fA11 i1="28" i2="1"><s1>GEJMAN (Pablo V.)</s1></fA11><fA14 i1="01"><s1>Departments of Psychiatry and Genetics, Washington University</s1><s2>St. Louis</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>26 aut.</sZ></fA14><fA14 i1="02"><s1>Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University</s1><s2>Evanston, IL</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>18 aut.</sZ><sZ>28 aut.</sZ></fA14><fA14 i1="03"><s1>School of Nursing, Louisiana State University Health Sciences Center</s1><s2>New Orleans</s2><s3>USA</s3><sZ>7 aut.</sZ></fA14><fA14 i1="04"><s1>Mental Health Clinical Research Center and Department of Psychiatry, University of Iowa College of Medicine</s1><s2>Iowa City</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>22 aut.</sZ><sZ>24 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University</s1><s3>USA</s3><sZ>9 aut.</sZ></fA14><fA14 i1="06"><s1>Queensland Centre for Schizophrenia Mental Health Research, The Park, Centre for Mental Health</s1><s2>Wacol</s2><s3>AUS</s3><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>19 aut.</sZ></fA14><fA14 i1="07"><s1>Department of Psychiatry, University of Queensland</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>19 aut.</sZ></fA14><fA14 i1="08"><s1>Department of Psychiatry and Colorado Psychiatric Health, University of Colorado School of Medicine</s1><s2>Denver</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>25 aut.</sZ></fA14><fA14 i1="09"><s1>Atlanta VA Medical Center and Department of Psychiatry and Behavioral Sciences, Emory University</s1><s2>Atlanta</s2><s3>USA</s3><sZ>12 aut.</sZ><sZ>20 aut.</sZ></fA14><fA14 i1="10"><s1>Department of Psychiatry, Mount Sinai School of Medicine</s1><s2>New York</s2><s3>USA</s3><sZ>14 aut.</sZ><sZ>21 aut.</sZ></fA14><fA14 i1="11"><s1>Department of Medicine, University of Chicago</s1><s2>Chicago</s2><s3>USA</s3><sZ>17 aut.</sZ></fA14><fA14 i1="12"><s1>Méthodologie Statistique et Epidémiologie Génétique des Maladies Multifactorielles, Institut National de la Recherche et de la Santé Médicale</s1><s2>Evry</s2><s3>FRA</s3><sZ>18 aut.</sZ></fA14><fA14 i1="13"><s1>Baylor College of Medicine</s1><s2>Houston</s2><s3>USA</s3><sZ>20 aut.</sZ></fA14><fA14 i1="14"><s1>Department of Psychiatry, University of California at Irvine</s1><s2>Irvine</s2><s3>USA</s3><sZ>23 aut.</sZ></fA14><fA14 i1="15"><s1>Department of Psychiatry, University of California-San Francisco</s1><s2>San Francisco</s2><s3>USA</s3><sZ>23 aut.</sZ></fA14><fA14 i1="16"><s1>Department of Psychiatry, University of Pennsylvania</s1><s2>Philadelphia</s2><s3>USA</s3><sZ>27 aut.</sZ></fA14><fA20><s1>315-333</s1></fA20><fA21><s1>2006</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>2610</s2><s5>354000132911260120</s5></fA43><fA44><s0>0000</s0><s1>© 2006 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>2 p.1/4</s0></fA45><fA47 i1="01" i2="1"><s0>06-0468036</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>American journal of human genetics</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>We report the clinical characteristics of a schizophrenia sample of 409 pedigrees-263 of European ancestry (EA) and 146 of African American ancestry (AA)-together with the results of a genome scan (with a simple tandem repeat polymorphism interval of 9 cM) and follow-up fine mapping. A family was required to have a proband with schizophrenia (SZ) and one or more siblings of the proband with SZ or schizoaffective disorder. Linkage analyses included 403 independent full-sibling affected sibling pairs (ASPs) (279 EA and 124 AA) and 100 all-possible half-sibling ASPs (15 EA and 85 AA). Nonparametric multipoint linkage analysis of all families detected two regions with suggestive evidence of linkage at 8p23.3-q12 and llpll.2-q22.3 (empirical Z likelihood-ratio score [Z<sub>lr</sub>] threshold ≥2.65) and, in exploratory analyses, two other regions at 4p16.1-p15.32 in AA families and at 5p14.3-q11.2 in EA families. The most significant linkage peak was in chromosome 8p; its signal was mainly driven by the EA families. Z<sub>lr</sub> scores >2.0 in 8p were observed from 30.7 cM to 61.7 cM (Center for Inherited Disease Research map locations). The maximum evidence in the full sample was a multipoint Z<sub>lr</sub> of 3.25 (equivalent Kong-Cox LOD of 2.30) near D8S1771 (at 52 cM); there appeared to be two peaks, both telomeric to neuregulin 1 (NRG1). There is a paracentric inversion common in EA individuals within this region, the effect of which on the linkage evidence remains unknown in this and in other previously analyzed samples. Fine mapping of 8p did not significantly alter the significance or length of the peak. We also performed fine mapping of 4p16.3-p15.2, 5p15.2-q13.3, 10p15.3-p14, 10q25.3-q26.3, and 11p13-q23.3. The highest increase in Z<sub>lr</sub> scores was observed for 5p14.1-q12.1, where the maximum Z<sub>lr</sub> increased from 2.77 initially to 3.80 after fine mapping in the EA families.</s0></fC01><fC02 i1="01" i2="X"><s0>002A04</s0></fC02><fC02 i1="02" i2="X"><s0>002A07C03</s0></fC02><fC02 i1="03" i2="X"><s0>002B23A</s0></fC02><fC02 i1="04" i2="X"><s0>002B18C06A</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Schizophrénie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Schizophrenia</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Esquizofrenia</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Génome</s0><s5>09</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Genome</s0><s5>09</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Genoma</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Pathogénie</s0><s5>10</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Pathogenesis</s0><s5>10</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Patogenia</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Déterminisme génétique</s0><s5>11</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Genetic determinism</s0><s5>11</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Determinismo genético</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Liaison génétique</s0><s5>12</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Genetic linkage</s0><s5>12</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Ligamiento genético</s0><s5>12</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Carte génétique</s0><s5>13</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Genetic mapping</s0><s5>13</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Mapa genético</s0><s5>13</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Européen</s0><s5>14</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>European</s0><s5>14</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Europeo</s0><s5>14</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Europe</s0><s2>NG</s2><s5>15</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Europe</s0><s2>NG</s2><s5>15</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Europa</s0><s2>NG</s2><s5>15</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Afro Américain</s0><s5>16</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>African American</s0><s5>16</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Afroamericano</s0><s5>16</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>Etude familiale</s0><s5>17</s5></fC03><fC03 i1="10" i2="X" l="ENG"><s0>Family study</s0><s5>17</s5></fC03><fC03 i1="10" i2="X" l="SPA"><s0>Estudio familiar</s0><s5>17</s5></fC03><fC03 i1="11" i2="X" l="FRE"><s0>Gène CDKN1A</s0><s5>18</s5></fC03><fC03 i1="11" i2="X" l="ENG"><s0>CDKN1A Gene</s0><s5>18</s5></fC03><fC03 i1="11" i2="X" l="SPA"><s0>Gen CDKN1A</s0><s5>18</s5></fC03><fC03 i1="12" i2="X" l="FRE"><s0>Echantillon</s0><s5>19</s5></fC03><fC03 i1="12" i2="X" l="ENG"><s0>Sample</s0><s5>19</s5></fC03><fC03 i1="12" i2="X" l="SPA"><s0>Muestra</s0><s5>19</s5></fC03><fC03 i1="13" i2="X" l="FRE"><s0>Génétique</s0><s5>20</s5></fC03><fC03 i1="13" i2="X" l="ENG"><s0>Genetics</s0><s5>20</s5></fC03><fC03 i1="13" i2="X" l="SPA"><s0>Genética</s0><s5>20</s5></fC03><fC03 i1="14" i2="X" l="FRE"><s0>Homme</s0><s5>21</s5></fC03><fC03 i1="14" i2="X" l="ENG"><s0>Human</s0><s5>21</s5></fC03><fC03 i1="14" i2="X" l="SPA"><s0>Hombre</s0><s5>21</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Psychose</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Psychosis</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Psicosis</s0><s5>37</s5></fC07><fN21><s1>310</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard><server><NO>PASCAL 06-0468036 INIST</NO><ET>Genomewide linkage scan of 409 European-ancestry and African American families with schizophrenia : Suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sample</ET><AU>SUAREZ (Brian K.); DUAN (Jubao); SANDERS (Alan R.); HINRICHS (Anthony L.); JIN (Carol H.); CUIPING HOU; BUCCOLA (Nancy G.); HALE (Nancy); WEILBAECHER (Ann N.); NERTNEY (Deborah A.); OLINCY (Ann); GREEN (Susan); SCHAFFER (Arthur W.); SMITH (Christopher J.); HANNAH (Dominique E.); RICE (John P.); COX (Nancy J.); MARTINEZ (Maria); MOWRY (Bryan J.); AMIN (Farooq); SILVERMAN (Jeremy M.); BLACK (Donald W.); BYERLEY (William F.); CROWE (Raymond R.); FREEDMAN (Robert); CLONINGER (C. Robert); LEVINSON (Douglas F.); GEJMAN (Pablo V.)</AU><AF>Departments of Psychiatry and Genetics, Washington University/St. Louis/Etats-Unis (1 aut., 4 aut., 5 aut., 13 aut., 16 aut., 26 aut.); Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University/Evanston, IL/Etats-Unis (2 aut., 3 aut., 6 aut., 18 aut., 28 aut.); School of Nursing, Louisiana State University Health Sciences Center/New Orleans/Etats-Unis (7 aut.); Mental Health Clinical Research Center and Department of Psychiatry, University of Iowa College of Medicine/Iowa City/Etats-Unis (8 aut., 22 aut., 24 aut.); Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University/Etats-Unis (9 aut.); Queensland Centre for Schizophrenia Mental Health Research, The Park, Centre for Mental Health/Wacol/Australie (10 aut., 15 aut., 19 aut.); Department of Psychiatry, University of Queensland/Brisbane/Australie (10 aut., 15 aut., 19 aut.); Department of Psychiatry and Colorado Psychiatric Health, University of Colorado School of Medicine/Denver/Etats-Unis (11 aut., 25 aut.); Atlanta VA Medical Center and Department of Psychiatry and Behavioral Sciences, Emory University/Atlanta/Etats-Unis (12 aut., 20 aut.); Department of Psychiatry, Mount Sinai School of Medicine/New York/Etats-Unis (14 aut., 21 aut.); Department of Medicine, University of Chicago/Chicago/Etats-Unis (17 aut.); Méthodologie Statistique et Epidémiologie Génétique des Maladies Multifactorielles, Institut National de la Recherche et de la Santé Médicale/Evry/France (18 aut.); Baylor College of Medicine/Houston/Etats-Unis (20 aut.); Department of Psychiatry, University of California at Irvine/Irvine/Etats-Unis (23 aut.); Department of Psychiatry, University of California-San Francisco/San Francisco/Etats-Unis (23 aut.); Department of Psychiatry, University of Pennsylvania/Philadelphia/Etats-Unis (27 aut.)</AF><DT>Publication en série; Niveau analytique</DT><SO>American journal of human genetics; ISSN 0002-9297; Coden AJHGAG; Etats-Unis; Da. 2006; Vol. 78; No. 2; Pp. 315-333; Bibl. 2 p.1/4</SO><LA>Anglais</LA><EA>We report the clinical characteristics of a schizophrenia sample of 409 pedigrees-263 of European ancestry (EA) and 146 of African American ancestry (AA)-together with the results of a genome scan (with a simple tandem repeat polymorphism interval of 9 cM) and follow-up fine mapping. A family was required to have a proband with schizophrenia (SZ) and one or more siblings of the proband with SZ or schizoaffective disorder. Linkage analyses included 403 independent full-sibling affected sibling pairs (ASPs) (279 EA and 124 AA) and 100 all-possible half-sibling ASPs (15 EA and 85 AA). Nonparametric multipoint linkage analysis of all families detected two regions with suggestive evidence of linkage at 8p23.3-q12 and llpll.2-q22.3 (empirical Z likelihood-ratio score [Z<sub>lr</sub>] threshold ≥2.65) and, in exploratory analyses, two other regions at 4p16.1-p15.32 in AA families and at 5p14.3-q11.2 in EA families. The most significant linkage peak was in chromosome 8p; its signal was mainly driven by the EA families. Z<sub>lr</sub> scores >2.0 in 8p were observed from 30.7 cM to 61.7 cM (Center for Inherited Disease Research map locations). The maximum evidence in the full sample was a multipoint Z<sub>lr</sub> of 3.25 (equivalent Kong-Cox LOD of 2.30) near D8S1771 (at 52 cM); there appeared to be two peaks, both telomeric to neuregulin 1 (NRG1). There is a paracentric inversion common in EA individuals within this region, the effect of which on the linkage evidence remains unknown in this and in other previously analyzed samples. Fine mapping of 8p did not significantly alter the significance or length of the peak. We also performed fine mapping of 4p16.3-p15.2, 5p15.2-q13.3, 10p15.3-p14, 10q25.3-q26.3, and 11p13-q23.3. The highest increase in Z<sub>lr</sub> scores was observed for 5p14.1-q12.1, where the maximum Z<sub>lr</sub> increased from 2.77 initially to 3.80 after fine mapping in the EA families.</EA><CC>002A04; 002A07C03; 002B23A; 002B18C06A</CC><FD>Schizophrénie; Génome; Pathogénie; Déterminisme génétique; Liaison génétique; Carte génétique; Européen; Europe; Afro Américain; Etude familiale; Gène CDKN1A; Echantillon; Génétique; Homme</FD><FG>Psychose</FG><ED>Schizophrenia; Genome; Pathogenesis; Genetic determinism; Genetic linkage; Genetic mapping; European; Europe; African American; Family study; CDKN1A Gene; Sample; Genetics; Human</ED><EG>Psychosis</EG><SD>Esquizofrenia; Genoma; Patogenia; Determinismo genético; Ligamiento genético; Mapa genético; Europeo; Europa; Afroamericano; Estudio familiar; Gen CDKN1A; Muestra; Genética; Hombre</SD><LO>INIST-2610.354000132911260120</LO><ID>06-0468036</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
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