AustralieFrV1, PascalFrancis, Corpus, bibRecord, 003A83

Exposure to substances in the workplace and new-onset asthma : an international prospective population-based study (ECRHS-II). Commentary

Identifieur interne : 003A83 ( PascalFrancis/Corpus ); précédent : 003A82; suivant : 003A84

Exposure to substances in the workplace and new-onset asthma : an international prospective population-based study (ECRHS-II). Commentary

Auteurs : Jean-Luc Malo ; Denyse Gautrin ; Manolis Kogevinas ; Jan-Paul Zock ; Debbie Jarvis ; Hans Kromhout ; Linnéa Lillienberg ; Estel Plana ; Katja Radon ; Kjell Taren ; Ada Alliksoo ; Geza Benke ; Paul D. Blanc ; Anna Dahlman-Hoglund ; Angelo D'Errico ; Michel Hery ; Susan Kennedy ; Nino Kunzli ; Bénédicte Leynaert ; Maria C. Mirabelli ; Nerea Muniozguren ; Dan Norback ; Mario Olivieri ; Félix Payo ; Simona Villani ; Marc Van Sprundel ; Isabel Urrutia ; Gunilla Wieslander ; Jordi Sunyer ; Josep M. Anto

Source :

Lancet : (British edition) [ 0140-6736 ] ; 2007.

RBID : Pascal:07-0364785

Descripteurs français

Pascal (Inist)
- Asthme, Exposition professionnelle, Stade précoce, International, Monde, Epidémiologie, Santé publique, Prospective, Population, Médecine.

English descriptors

KwdEn :
- Asthma, Early stage, Epidemiology, International, Medicine, Occupational exposure, Population, Prospective, Public health, World.

Abstract

Background The role of exposure to substances in the workplace in new-onset asthma is not well characterised in population-based studies. We therefore aimed to estimate the relative and attributable risks of new-onset asthma in relation to occupations, work-related exposures, and inhalation accidents. Methods We studied prospectively 6837 participants from 13 countries who previously took part in the European Community Respiratory Health Survey (1990-95) and did not report respiratory symptoms or a history of asthma at the time of the first study. Asthma was assessed by methacholine challenge test and by questionnaire data on asthma symptoms. Exposures were defined by high-risk occupations, an asthma-specific job exposure matrix with additional expert judgment, and through self-report of acute inhalation events. Relative risks for new onset asthma were calculated with log-binomial models adjusted for age, sex, smoking, and study centre. Findings A significant excess asthma risk was seen after exposure to substances known to cause occupational asthma (Relative risk=1.6, 95% CI 1.1-2.3, p=0.017). Risks were highest for asthma defined by bronchial hyper-reactivity in addition to symptoms (2.4, 1.3-4.6, p=0.008). Of common occupations, a significant excess risk of asthma was seen for nursing (2.2, 1.3-4.0, p=0.007). Asthma risk was also increased in participants who reported an acute symptomatic inhalation event such as fire, mixing cleaning products, or chemical spills (RR=3.3, 95% CI 1.0-11.1, p=0.051). The population-attributable risk for adult asthma due to occupational exposures ranged from 10% to 25%, equivalent to an incidence of new-onset occupational asthma of 250-300 cases per million people per year. Interpretation Occupational exposures account for a substantial proportion of adult asthma incidence. The increased risk of asthma after inhalation accidents suggests that workers who have such accidents should be monitored closely.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`01`	`1`		`@1 MALO (Jean-Luc) @9 comment.`
A11	`02`	`1`		`@1 GAUTRIN (Denyse) @9 comment.`
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A11	`09`	`1`		`@1 RADON (Katja)`
A11	`10`	`1`		`@1 TAREN (Kjell)`
A11	`11`	`1`		`@1 ALLIKSOO (Ada)`
A11	`12`	`1`		`@1 BENKE (Geza)`
A11	`13`	`1`		`@1 BLANC (Paul D.)`
A11	`14`	`1`		`@1 DAHLMAN-HOGLUND (Anna)`
A11	`15`	`1`		`@1 D'ERRICO (Angelo)`
A11	`16`	`1`		`@1 HERY (Michel)`
A11	`17`	`1`		`@1 KENNEDY (Susan)`
A11	`18`	`1`		`@1 KUNZLI (Nino)`
A11	`19`	`1`		`@1 LEYNAERT (Bénédicte)`
A11	`20`	`1`		`@1 MIRABELLI (Maria C.)`
A11	`21`	`1`		`@1 MUNIOZGUREN (Nerea)`
A11	`22`	`1`		`@1 NORBACK (Dan)`
A11	`23`	`1`		`@1 OLIVIERI (Mario)`
A11	`24`	`1`		`@1 PAYO (Félix)`
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A11	`29`	`1`		`@1 SUNYER (Jordi)`
A11	`30`	`1`		`@1 ANTO (Josep M.)`
A14	`01`			`@1 Axe de recherche en santé respiratoire and Center for Asthma in the Workplace, Department of Chest Medicine, Sacré-Coeur Hospital @2 Montreal, H4J 1C5 @3 CAN @Z 1 aut. @Z 2 aut.`
A14	`02`			`@1 Centre for Research in Environmental Epidemiology, Municipal Institute of Medical Research @2 Barcelona @3 ESP @Z 3 aut. @Z 4 aut. @Z 8 aut. @Z 18 aut. @Z 20 aut. @Z 29 aut. @Z 30 aut.`
A14	`03`			`@1 Medical School, University of Crete @2 Heraklion @3 GRC @Z 3 aut.`
A14	`04`			`@1 Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College @2 London @3 GBR @Z 5 aut.`
A14	`05`			`@1 Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University @2 Utrecht @3 NLD @Z 6 aut.`
A14	`06`			`@1 Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital @2 Goteborg @3 SWE @Z 7 aut. @Z 10 aut. @Z 14 aut.`
A14	`07`			`@1 Unit for Occupational and Environmental Epidemiology and NetTeaching, Institute for Occupational and Environmental Medicine, Ludwig-Maximilians-University @2 Munich @3 DEU @Z 9 aut.`
A14	`08`			`@1 Tartu University Clinics, Lung Clinic @2 Tartu @3 EST @Z 11 aut.`
A14	`09`			`@1 Department of Epidemiology and Preventive Medicine, Monash University @2 VIC @3 AUS @Z 12 aut.`
A14	`10`			`@1 Division of Occupational and Environmental Medicine, Department of Medicine, University of California San Francisco @2 San Francisco, CA @3 USA @Z 13 aut.`
A14	`11`			`@1 Servizio Regionale di Epidemiologia @2 Turin @3 ITA @Z 15 aut.`
A14	`12`			`@1 Institut National de Recherche et de Sécurité @2 Vandoeuvre -lès -Nancy @3 FRA @Z 16 aut.`
A14	`13`			`@1 School of Occupational and Environmental Hygiene, University of British Columbia @2 Vancouver, BC @3 CAN @Z 17 aut.`
A14	`14`			`@1 INSERM-The French Institute of Health and Medical Research, Unit 700-Epidemiology, Faculty of Medicine X Bichat @2 Paris @3 FRA @Z 19 aut.`
A14	`15`			`@1 Epidemiology Unit, Public Health Department of Bizkaia @2 Galolatao @3 ESP @Z 21 aut.`
A20				`@2 295-297, 336-341 [9 p.]`
A21				`@1 2007`
A23	`01`			`@0 ENG`
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C01	`01`		`ENG`	@0 Background The role of exposure to substances in the workplace in new-onset asthma is not well characterised in population-based studies. We therefore aimed to estimate the relative and attributable risks of new-onset asthma in relation to occupations, work-related exposures, and inhalation accidents. Methods We studied prospectively 6837 participants from 13 countries who previously took part in the European Community Respiratory Health Survey (1990-95) and did not report respiratory symptoms or a history of asthma at the time of the first study. Asthma was assessed by methacholine challenge test and by questionnaire data on asthma symptoms. Exposures were defined by high-risk occupations, an asthma-specific job exposure matrix with additional expert judgment, and through self-report of acute inhalation events. Relative risks for new onset asthma were calculated with log-binomial models adjusted for age, sex, smoking, and study centre. Findings A significant excess asthma risk was seen after exposure to substances known to cause occupational asthma (Relative risk=1.6, 95% CI 1.1-2.3, p=0.017). Risks were highest for asthma defined by bronchial hyper-reactivity in addition to symptoms (2.4, 1.3-4.6, p=0.008). Of common occupations, a significant excess risk of asthma was seen for nursing (2.2, 1.3-4.0, p=0.007). Asthma risk was also increased in participants who reported an acute symptomatic inhalation event such as fire, mixing cleaning products, or chemical spills (RR=3.3, 95% CI 1.0-11.1, p=0.051). The population-attributable risk for adult asthma due to occupational exposures ranged from 10% to 25%, equivalent to an incidence of new-onset occupational asthma of 250-300 cases per million people per year. Interpretation Occupational exposures account for a substantial proportion of adult asthma incidence. The increased risk of asthma after inhalation accidents suggests that workers who have such accidents should be monitored closely.
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C03	`01`	`X`	`ENG`	`@0 Asthma @5 01`
C03	`01`	`X`	`SPA`	`@0 Asma @5 01`
C03	`02`	`X`	`FRE`	`@0 Exposition professionnelle @5 02`
C03	`02`	`X`	`ENG`	`@0 Occupational exposure @5 02`
C03	`02`	`X`	`SPA`	`@0 Exposición profesional @5 02`
C03	`03`	`X`	`FRE`	`@0 Stade précoce @5 03`
C03	`03`	`X`	`ENG`	`@0 Early stage @5 03`
C03	`03`	`X`	`SPA`	`@0 Estadio precoz @5 03`
C03	`04`	`X`	`FRE`	`@0 International @5 05`
C03	`04`	`X`	`ENG`	`@0 International @5 05`
C03	`04`	`X`	`SPA`	`@0 Internacional @5 05`
C03	`05`	`X`	`FRE`	`@0 Monde @2 NG @5 06`
C03	`05`	`X`	`ENG`	`@0 World @2 NG @5 06`
C03	`05`	`X`	`SPA`	`@0 Mundo @2 NG @5 06`
C03	`06`	`X`	`FRE`	`@0 Epidémiologie @5 08`
C03	`06`	`X`	`ENG`	`@0 Epidemiology @5 08`
C03	`06`	`X`	`SPA`	`@0 Epidemiología @5 08`
C03	`07`	`X`	`FRE`	`@0 Santé publique @5 09`
C03	`07`	`X`	`ENG`	`@0 Public health @5 09`
C03	`07`	`X`	`SPA`	`@0 Salud pública @5 09`
C03	`08`	`X`	`FRE`	`@0 Prospective @5 11`
C03	`08`	`X`	`ENG`	`@0 Prospective @5 11`
C03	`08`	`X`	`SPA`	`@0 Prospectiva @5 11`
C03	`09`	`X`	`FRE`	`@0 Population @5 12`
C03	`09`	`X`	`ENG`	`@0 Population @5 12`
C03	`09`	`X`	`SPA`	`@0 Población @5 12`
C03	`10`	`X`	`FRE`	`@0 Médecine @5 17`
C03	`10`	`X`	`ENG`	`@0 Medicine @5 17`
C03	`10`	`X`	`SPA`	`@0 Medicina @5 17`
C07	`01`	`X`	`FRE`	`@0 Appareil respiratoire pathologie @5 37`
C07	`01`	`X`	`ENG`	`@0 Respiratory disease @5 37`
C07	`01`	`X`	`SPA`	`@0 Aparato respiratorio patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Bronchopneumopathie obstructive @5 38`
C07	`02`	`X`	`ENG`	`@0 Obstructive pulmonary disease @5 38`
C07	`02`	`X`	`SPA`	`@0 Broncopneumopatía obstructiva @5 38`
C07	`03`	`X`	`FRE`	`@0 Bronche pathologie @5 39`
C07	`03`	`X`	`ENG`	`@0 Bronchus disease @5 39`
C07	`03`	`X`	`SPA`	`@0 Bronquio patología @5 39`
C07	`04`	`X`	`FRE`	`@0 Poumon pathologie @5 40`
C07	`04`	`X`	`ENG`	`@0 Lung disease @5 40`
C07	`04`	`X`	`SPA`	`@0 Pulmón patología @5 40`
N21				`@1 232`
N44	`01`			`@1 OTO`
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Format Inist (serveur)

NO :	PASCAL 07-0364785 INIST
ET :	Exposure to substances in the workplace and new-onset asthma : an international prospective population-based study (ECRHS-II). Commentary
AU :	MALO (Jean-Luc); GAUTRIN (Denyse); KOGEVINAS (Manolis); ZOCK (Jan-Paul); JARVIS (Debbie); KROMHOUT (Hans); LILLIENBERG (Linnéa); PLANA (Estel); RADON (Katja); TAREN (Kjell); ALLIKSOO (Ada); BENKE (Geza); BLANC (Paul D.); DAHLMAN-HOGLUND (Anna); D'ERRICO (Angelo); HERY (Michel); KENNEDY (Susan); KUNZLI (Nino); LEYNAERT (Bénédicte); MIRABELLI (Maria C.); MUNIOZGUREN (Nerea); NORBACK (Dan); OLIVIERI (Mario); PAYO (Félix); VILLANI (Simona); VAN SPRUNDEL (Marc); URRUTIA (Isabel); WIESLANDER (Gunilla); SUNYER (Jordi); ANTO (Josep M.)
AF :	Axe de recherche en santé respiratoire and Center for Asthma in the Workplace, Department of Chest Medicine, Sacré-Coeur Hospital/Montreal, H4J 1C5/Canada (1 aut., 2 aut.); Centre for Research in Environmental Epidemiology, Municipal Institute of Medical Research/Barcelona/Espagne (3 aut., 4 aut., 8 aut., 18 aut., 20 aut., 29 aut., 30 aut.); Medical School, University of Crete/Heraklion/Grèce (3 aut.); Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College/London/Royaume-Uni (5 aut.); Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University/Utrecht/Pays-Bas (6 aut.); Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital/Goteborg/Suède (7 aut., 10 aut., 14 aut.); Unit for Occupational and Environmental Epidemiology and NetTeaching, Institute for Occupational and Environmental Medicine, Ludwig-Maximilians-University/Munich/Allemagne (9 aut.); Tartu University Clinics, Lung Clinic/Tartu/Estonie (11 aut.); Department of Epidemiology and Preventive Medicine, Monash University/VIC/Australie (12 aut.); Division of Occupational and Environmental Medicine, Department of Medicine, University of California San Francisco/San Francisco, CA/Etats-Unis (13 aut.); Servizio Regionale di Epidemiologia/Turin/Italie (15 aut.); Institut National de Recherche et de Sécurité/Vandoeuvre -lès -Nancy/France (16 aut.); School of Occupational and Environmental Hygiene, University of British Columbia/Vancouver, BC/Canada (17 aut.); INSERM-The French Institute of Health and Medical Research, Unit 700-Epidemiology, Faculty of Medicine X Bichat/Paris/France (19 aut.); Epidemiology Unit, Public Health Department of Bizkaia/Galolatao/Espagne (21 aut.)
DT :	Publication en série; Niveau analytique
SO :	Lancet : (British edition); ISSN 0140-6736; Coden LANCAO; Royaume-Uni; Da. 2007; Vol. 370; No. 9584; 295-297, 336-341 [9 p.]; Bibl. 27 ref.
LA :	Anglais
EA :	Background The role of exposure to substances in the workplace in new-onset asthma is not well characterised in population-based studies. We therefore aimed to estimate the relative and attributable risks of new-onset asthma in relation to occupations, work-related exposures, and inhalation accidents. Methods We studied prospectively 6837 participants from 13 countries who previously took part in the European Community Respiratory Health Survey (1990-95) and did not report respiratory symptoms or a history of asthma at the time of the first study. Asthma was assessed by methacholine challenge test and by questionnaire data on asthma symptoms. Exposures were defined by high-risk occupations, an asthma-specific job exposure matrix with additional expert judgment, and through self-report of acute inhalation events. Relative risks for new onset asthma were calculated with log-binomial models adjusted for age, sex, smoking, and study centre. Findings A significant excess asthma risk was seen after exposure to substances known to cause occupational asthma (Relative risk=1.6, 95% CI 1.1-2.3, p=0.017). Risks were highest for asthma defined by bronchial hyper-reactivity in addition to symptoms (2.4, 1.3-4.6, p=0.008). Of common occupations, a significant excess risk of asthma was seen for nursing (2.2, 1.3-4.0, p=0.007). Asthma risk was also increased in participants who reported an acute symptomatic inhalation event such as fire, mixing cleaning products, or chemical spills (RR=3.3, 95% CI 1.0-11.1, p=0.051). The population-attributable risk for adult asthma due to occupational exposures ranged from 10% to 25%, equivalent to an incidence of new-onset occupational asthma of 250-300 cases per million people per year. Interpretation Occupational exposures account for a substantial proportion of adult asthma incidence. The increased risk of asthma after inhalation accidents suggests that workers who have such accidents should be monitored closely.
CC :	002B01; 002B30B04; 002B11B
FD :	Asthme; Exposition professionnelle; Stade précoce; International; Monde; Epidémiologie; Santé publique; Prospective; Population; Médecine
FG :	Appareil respiratoire pathologie; Bronchopneumopathie obstructive; Bronche pathologie; Poumon pathologie
ED :	Asthma; Occupational exposure; Early stage; International; World; Epidemiology; Public health; Prospective; Population; Medicine
EG :	Respiratory disease; Obstructive pulmonary disease; Bronchus disease; Lung disease
SD :	Asma; Exposición profesional; Estadio precoz; Internacional; Mundo; Epidemiología; Salud pública; Prospectiva; Población; Medicina
LO :	INIST-5004.354000162396270130
ID :	07-0364785

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Pascal:07-0364785

Le document en format XML

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<author><name sortKey="Kromhout, Hans" sort="Kromhout, Hans" uniqKey="Kromhout H" first="Hans" last="Kromhout">Hans Kromhout</name>
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<author><name sortKey="Lillienberg, Linnea" sort="Lillienberg, Linnea" uniqKey="Lillienberg L" first="Linnéa" last="Lillienberg">Linnéa Lillienberg</name>
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<author><name sortKey="Plana, Estel" sort="Plana, Estel" uniqKey="Plana E" first="Estel" last="Plana">Estel Plana</name>
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<author><name sortKey="Alliksoo, Ada" sort="Alliksoo, Ada" uniqKey="Alliksoo A" first="Ada" last="Alliksoo">Ada Alliksoo</name>
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<author><name sortKey="Benke, Geza" sort="Benke, Geza" uniqKey="Benke G" first="Geza" last="Benke">Geza Benke</name>
<affiliation><inist:fA14 i1="09"><s1>Department of Epidemiology and Preventive Medicine, Monash University</s1>
<s2>VIC</s2>
<s3>AUS</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Blanc, Paul D" sort="Blanc, Paul D" uniqKey="Blanc P" first="Paul D." last="Blanc">Paul D. Blanc</name>
<affiliation><inist:fA14 i1="10"><s1>Division of Occupational and Environmental Medicine, Department of Medicine, University of California San Francisco</s1>
<s2>San Francisco, CA</s2>
<s3>USA</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Dahlman Hoglund, Anna" sort="Dahlman Hoglund, Anna" uniqKey="Dahlman Hoglund A" first="Anna" last="Dahlman-Hoglund">Anna Dahlman-Hoglund</name>
<affiliation><inist:fA14 i1="06"><s1>Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital</s1>
<s2>Goteborg</s2>
<s3>SWE</s3>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="D Errico, Angelo" sort="D Errico, Angelo" uniqKey="D Errico A" first="Angelo" last="D'Errico">Angelo D'Errico</name>
<affiliation><inist:fA14 i1="11"><s1>Servizio Regionale di Epidemiologia</s1>
<s2>Turin</s2>
<s3>ITA</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Hery, Michel" sort="Hery, Michel" uniqKey="Hery M" first="Michel" last="Hery">Michel Hery</name>
<affiliation><inist:fA14 i1="12"><s1>Institut National de Recherche et de Sécurité</s1>
<s2>Vandoeuvre -lès -Nancy</s2>
<s3>FRA</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Kennedy, Susan" sort="Kennedy, Susan" uniqKey="Kennedy S" first="Susan" last="Kennedy">Susan Kennedy</name>
<affiliation><inist:fA14 i1="13"><s1>School of Occupational and Environmental Hygiene, University of British Columbia</s1>
<s2>Vancouver, BC</s2>
<s3>CAN</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Kunzli, Nino" sort="Kunzli, Nino" uniqKey="Kunzli N" first="Nino" last="Kunzli">Nino Kunzli</name>
<affiliation><inist:fA14 i1="02"><s1>Centre for Research in Environmental Epidemiology, Municipal Institute of Medical Research</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Leynaert, Benedicte" sort="Leynaert, Benedicte" uniqKey="Leynaert B" first="Bénédicte" last="Leynaert">Bénédicte Leynaert</name>
<affiliation><inist:fA14 i1="14"><s1>INSERM-The French Institute of Health and Medical Research, Unit 700-Epidemiology, Faculty of Medicine X Bichat</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Mirabelli, Maria C" sort="Mirabelli, Maria C" uniqKey="Mirabelli M" first="Maria C." last="Mirabelli">Maria C. Mirabelli</name>
<affiliation><inist:fA14 i1="02"><s1>Centre for Research in Environmental Epidemiology, Municipal Institute of Medical Research</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Muniozguren, Nerea" sort="Muniozguren, Nerea" uniqKey="Muniozguren N" first="Nerea" last="Muniozguren">Nerea Muniozguren</name>
<affiliation><inist:fA14 i1="15"><s1>Epidemiology Unit, Public Health Department of Bizkaia</s1>
<s2>Galolatao</s2>
<s3>ESP</s3>
<sZ>21 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Norback, Dan" sort="Norback, Dan" uniqKey="Norback D" first="Dan" last="Norback">Dan Norback</name>
</author>
<author><name sortKey="Olivieri, Mario" sort="Olivieri, Mario" uniqKey="Olivieri M" first="Mario" last="Olivieri">Mario Olivieri</name>
</author>
<author><name sortKey="Payo, Felix" sort="Payo, Felix" uniqKey="Payo F" first="Félix" last="Payo">Félix Payo</name>
</author>
<author><name sortKey="Villani, Simona" sort="Villani, Simona" uniqKey="Villani S" first="Simona" last="Villani">Simona Villani</name>
</author>
<author><name sortKey="Van Sprundel, Marc" sort="Van Sprundel, Marc" uniqKey="Van Sprundel M" first="Marc" last="Van Sprundel">Marc Van Sprundel</name>
</author>
<author><name sortKey="Urrutia, Isabel" sort="Urrutia, Isabel" uniqKey="Urrutia I" first="Isabel" last="Urrutia">Isabel Urrutia</name>
</author>
<author><name sortKey="Wieslander, Gunilla" sort="Wieslander, Gunilla" uniqKey="Wieslander G" first="Gunilla" last="Wieslander">Gunilla Wieslander</name>
</author>
<author><name sortKey="Sunyer, Jordi" sort="Sunyer, Jordi" uniqKey="Sunyer J" first="Jordi" last="Sunyer">Jordi Sunyer</name>
<affiliation><inist:fA14 i1="02"><s1>Centre for Research in Environmental Epidemiology, Municipal Institute of Medical Research</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Anto, Josep M" sort="Anto, Josep M" uniqKey="Anto J" first="Josep M." last="Anto">Josep M. Anto</name>
<affiliation><inist:fA14 i1="02"><s1>Centre for Research in Environmental Epidemiology, Municipal Institute of Medical Research</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">07-0364785</idno>
<date when="2007">2007</date>
<idno type="stanalyst">PASCAL 07-0364785 INIST</idno>
<idno type="RBID">Pascal:07-0364785</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">003A83</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Exposure to substances in the workplace and new-onset asthma : an international prospective population-based study (ECRHS-II). Commentary</title>
<author><name sortKey="Malo, Jean Luc" sort="Malo, Jean Luc" uniqKey="Malo J" first="Jean-Luc" last="Malo">Jean-Luc Malo</name>
<affiliation><inist:fA14 i1="01"><s1>Axe de recherche en santé respiratoire and Center for Asthma in the Workplace, Department of Chest Medicine, Sacré-Coeur Hospital</s1>
<s2>Montreal, H4J 1C5</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Gautrin, Denyse" sort="Gautrin, Denyse" uniqKey="Gautrin D" first="Denyse" last="Gautrin">Denyse Gautrin</name>
<affiliation><inist:fA14 i1="01"><s1>Axe de recherche en santé respiratoire and Center for Asthma in the Workplace, Department of Chest Medicine, Sacré-Coeur Hospital</s1>
<s2>Montreal, H4J 1C5</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Kogevinas, Manolis" sort="Kogevinas, Manolis" uniqKey="Kogevinas M" first="Manolis" last="Kogevinas">Manolis Kogevinas</name>
<affiliation><inist:fA14 i1="02"><s1>Centre for Research in Environmental Epidemiology, Municipal Institute of Medical Research</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="03"><s1>Medical School, University of Crete</s1>
<s2>Heraklion</s2>
<s3>GRC</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Zock, Jan Paul" sort="Zock, Jan Paul" uniqKey="Zock J" first="Jan-Paul" last="Zock">Jan-Paul Zock</name>
<affiliation><inist:fA14 i1="02"><s1>Centre for Research in Environmental Epidemiology, Municipal Institute of Medical Research</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Jarvis, Debbie" sort="Jarvis, Debbie" uniqKey="Jarvis D" first="Debbie" last="Jarvis">Debbie Jarvis</name>
<affiliation><inist:fA14 i1="04"><s1>Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Kromhout, Hans" sort="Kromhout, Hans" uniqKey="Kromhout H" first="Hans" last="Kromhout">Hans Kromhout</name>
<affiliation><inist:fA14 i1="05"><s1>Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University</s1>
<s2>Utrecht</s2>
<s3>NLD</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Lillienberg, Linnea" sort="Lillienberg, Linnea" uniqKey="Lillienberg L" first="Linnéa" last="Lillienberg">Linnéa Lillienberg</name>
<affiliation><inist:fA14 i1="06"><s1>Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital</s1>
<s2>Goteborg</s2>
<s3>SWE</s3>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Plana, Estel" sort="Plana, Estel" uniqKey="Plana E" first="Estel" last="Plana">Estel Plana</name>
<affiliation><inist:fA14 i1="02"><s1>Centre for Research in Environmental Epidemiology, Municipal Institute of Medical Research</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Radon, Katja" sort="Radon, Katja" uniqKey="Radon K" first="Katja" last="Radon">Katja Radon</name>
<affiliation><inist:fA14 i1="07"><s1>Unit for Occupational and Environmental Epidemiology and NetTeaching, Institute for Occupational and Environmental Medicine, Ludwig-Maximilians-University</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Taren, Kjell" sort="Taren, Kjell" uniqKey="Taren K" first="Kjell" last="Taren">Kjell Taren</name>
<affiliation><inist:fA14 i1="06"><s1>Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital</s1>
<s2>Goteborg</s2>
<s3>SWE</s3>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Alliksoo, Ada" sort="Alliksoo, Ada" uniqKey="Alliksoo A" first="Ada" last="Alliksoo">Ada Alliksoo</name>
<affiliation><inist:fA14 i1="08"><s1>Tartu University Clinics, Lung Clinic</s1>
<s2>Tartu</s2>
<s3>EST</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Benke, Geza" sort="Benke, Geza" uniqKey="Benke G" first="Geza" last="Benke">Geza Benke</name>
<affiliation><inist:fA14 i1="09"><s1>Department of Epidemiology and Preventive Medicine, Monash University</s1>
<s2>VIC</s2>
<s3>AUS</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Blanc, Paul D" sort="Blanc, Paul D" uniqKey="Blanc P" first="Paul D." last="Blanc">Paul D. Blanc</name>
<affiliation><inist:fA14 i1="10"><s1>Division of Occupational and Environmental Medicine, Department of Medicine, University of California San Francisco</s1>
<s2>San Francisco, CA</s2>
<s3>USA</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Dahlman Hoglund, Anna" sort="Dahlman Hoglund, Anna" uniqKey="Dahlman Hoglund A" first="Anna" last="Dahlman-Hoglund">Anna Dahlman-Hoglund</name>
<affiliation><inist:fA14 i1="06"><s1>Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital</s1>
<s2>Goteborg</s2>
<s3>SWE</s3>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="D Errico, Angelo" sort="D Errico, Angelo" uniqKey="D Errico A" first="Angelo" last="D'Errico">Angelo D'Errico</name>
<affiliation><inist:fA14 i1="11"><s1>Servizio Regionale di Epidemiologia</s1>
<s2>Turin</s2>
<s3>ITA</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Hery, Michel" sort="Hery, Michel" uniqKey="Hery M" first="Michel" last="Hery">Michel Hery</name>
<affiliation><inist:fA14 i1="12"><s1>Institut National de Recherche et de Sécurité</s1>
<s2>Vandoeuvre -lès -Nancy</s2>
<s3>FRA</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Kennedy, Susan" sort="Kennedy, Susan" uniqKey="Kennedy S" first="Susan" last="Kennedy">Susan Kennedy</name>
<affiliation><inist:fA14 i1="13"><s1>School of Occupational and Environmental Hygiene, University of British Columbia</s1>
<s2>Vancouver, BC</s2>
<s3>CAN</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Kunzli, Nino" sort="Kunzli, Nino" uniqKey="Kunzli N" first="Nino" last="Kunzli">Nino Kunzli</name>
<affiliation><inist:fA14 i1="02"><s1>Centre for Research in Environmental Epidemiology, Municipal Institute of Medical Research</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Leynaert, Benedicte" sort="Leynaert, Benedicte" uniqKey="Leynaert B" first="Bénédicte" last="Leynaert">Bénédicte Leynaert</name>
<affiliation><inist:fA14 i1="14"><s1>INSERM-The French Institute of Health and Medical Research, Unit 700-Epidemiology, Faculty of Medicine X Bichat</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Mirabelli, Maria C" sort="Mirabelli, Maria C" uniqKey="Mirabelli M" first="Maria C." last="Mirabelli">Maria C. Mirabelli</name>
<affiliation><inist:fA14 i1="02"><s1>Centre for Research in Environmental Epidemiology, Municipal Institute of Medical Research</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Muniozguren, Nerea" sort="Muniozguren, Nerea" uniqKey="Muniozguren N" first="Nerea" last="Muniozguren">Nerea Muniozguren</name>
<affiliation><inist:fA14 i1="15"><s1>Epidemiology Unit, Public Health Department of Bizkaia</s1>
<s2>Galolatao</s2>
<s3>ESP</s3>
<sZ>21 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Norback, Dan" sort="Norback, Dan" uniqKey="Norback D" first="Dan" last="Norback">Dan Norback</name>
</author>
<author><name sortKey="Olivieri, Mario" sort="Olivieri, Mario" uniqKey="Olivieri M" first="Mario" last="Olivieri">Mario Olivieri</name>
</author>
<author><name sortKey="Payo, Felix" sort="Payo, Felix" uniqKey="Payo F" first="Félix" last="Payo">Félix Payo</name>
</author>
<author><name sortKey="Villani, Simona" sort="Villani, Simona" uniqKey="Villani S" first="Simona" last="Villani">Simona Villani</name>
</author>
<author><name sortKey="Van Sprundel, Marc" sort="Van Sprundel, Marc" uniqKey="Van Sprundel M" first="Marc" last="Van Sprundel">Marc Van Sprundel</name>
</author>
<author><name sortKey="Urrutia, Isabel" sort="Urrutia, Isabel" uniqKey="Urrutia I" first="Isabel" last="Urrutia">Isabel Urrutia</name>
</author>
<author><name sortKey="Wieslander, Gunilla" sort="Wieslander, Gunilla" uniqKey="Wieslander G" first="Gunilla" last="Wieslander">Gunilla Wieslander</name>
</author>
<author><name sortKey="Sunyer, Jordi" sort="Sunyer, Jordi" uniqKey="Sunyer J" first="Jordi" last="Sunyer">Jordi Sunyer</name>
<affiliation><inist:fA14 i1="02"><s1>Centre for Research in Environmental Epidemiology, Municipal Institute of Medical Research</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
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<author><name sortKey="Anto, Josep M" sort="Anto, Josep M" uniqKey="Anto J" first="Josep M." last="Anto">Josep M. Anto</name>
<affiliation><inist:fA14 i1="02"><s1>Centre for Research in Environmental Epidemiology, Municipal Institute of Medical Research</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>29 aut.</sZ>
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</analytic>
<series><title level="j" type="main">Lancet : (British edition)</title>
<title level="j" type="abbreviated">Lancet : (Br. ed.)</title>
<idno type="ISSN">0140-6736</idno>
<imprint><date when="2007">2007</date>
</imprint>
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<term>Early stage</term>
<term>Epidemiology</term>
<term>International</term>
<term>Medicine</term>
<term>Occupational exposure</term>
<term>Population</term>
<term>Prospective</term>
<term>Public health</term>
<term>World</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Asthme</term>
<term>Exposition professionnelle</term>
<term>Stade précoce</term>
<term>International</term>
<term>Monde</term>
<term>Epidémiologie</term>
<term>Santé publique</term>
<term>Prospective</term>
<term>Population</term>
<term>Médecine</term>
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<front><div type="abstract" xml:lang="en">Background The role of exposure to substances in the workplace in new-onset asthma is not well characterised in population-based studies. We therefore aimed to estimate the relative and attributable risks of new-onset asthma in relation to occupations, work-related exposures, and inhalation accidents. Methods We studied prospectively 6837 participants from 13 countries who previously took part in the European Community Respiratory Health Survey (1990-95) and did not report respiratory symptoms or a history of asthma at the time of the first study. Asthma was assessed by methacholine challenge test and by questionnaire data on asthma symptoms. Exposures were defined by high-risk occupations, an asthma-specific job exposure matrix with additional expert judgment, and through self-report of acute inhalation events. Relative risks for new onset asthma were calculated with log-binomial models adjusted for age, sex, smoking, and study centre. Findings A significant excess asthma risk was seen after exposure to substances known to cause occupational asthma (Relative risk=1.6, 95% CI 1.1-2.3, p=0.017). Risks were highest for asthma defined by bronchial hyper-reactivity in addition to symptoms (2.4, 1.3-4.6, p=0.008). Of common occupations, a significant excess risk of asthma was seen for nursing (2.2, 1.3-4.0, p=0.007). Asthma risk was also increased in participants who reported an acute symptomatic inhalation event such as fire, mixing cleaning products, or chemical spills (RR=3.3, 95% CI 1.0-11.1, p=0.051). The population-attributable risk for adult asthma due to occupational exposures ranged from 10% to 25%, equivalent to an incidence of new-onset occupational asthma of 250-300 cases per million people per year. Interpretation Occupational exposures account for a substantial proportion of adult asthma incidence. The increased risk of asthma after inhalation accidents suggests that workers who have such accidents should be monitored closely.</div>
</front>
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<fA08 i1="01" i2="1" l="ENG"><s1>Exposure to substances in the workplace and new-onset asthma : an international prospective population-based study (ECRHS-II). Commentary</s1>
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<s9>comment.</s9>
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<fA11 i1="02" i2="1"><s1>GAUTRIN (Denyse)</s1>
<s9>comment.</s9>
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<fA11 i1="03" i2="1"><s1>KOGEVINAS (Manolis)</s1>
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<fA11 i1="04" i2="1"><s1>ZOCK (Jan-Paul)</s1>
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<fA11 i1="05" i2="1"><s1>JARVIS (Debbie)</s1>
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<fA11 i1="06" i2="1"><s1>KROMHOUT (Hans)</s1>
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<fA11 i1="08" i2="1"><s1>PLANA (Estel)</s1>
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<fA11 i1="16" i2="1"><s1>HERY (Michel)</s1>
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<fA11 i1="21" i2="1"><s1>MUNIOZGUREN (Nerea)</s1>
</fA11>
<fA11 i1="22" i2="1"><s1>NORBACK (Dan)</s1>
</fA11>
<fA11 i1="23" i2="1"><s1>OLIVIERI (Mario)</s1>
</fA11>
<fA11 i1="24" i2="1"><s1>PAYO (Félix)</s1>
</fA11>
<fA11 i1="25" i2="1"><s1>VILLANI (Simona)</s1>
</fA11>
<fA11 i1="26" i2="1"><s1>VAN SPRUNDEL (Marc)</s1>
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<fA11 i1="27" i2="1"><s1>URRUTIA (Isabel)</s1>
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</fA11>
<fA11 i1="30" i2="1"><s1>ANTO (Josep M.)</s1>
</fA11>
<fA14 i1="01"><s1>Axe de recherche en santé respiratoire and Center for Asthma in the Workplace, Department of Chest Medicine, Sacré-Coeur Hospital</s1>
<s2>Montreal, H4J 1C5</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
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<fA14 i1="02"><s1>Centre for Research in Environmental Epidemiology, Municipal Institute of Medical Research</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Medical School, University of Crete</s1>
<s2>Heraklion</s2>
<s3>GRC</s3>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University</s1>
<s2>Utrecht</s2>
<s3>NLD</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital</s1>
<s2>Goteborg</s2>
<s3>SWE</s3>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>14 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>Unit for Occupational and Environmental Epidemiology and NetTeaching, Institute for Occupational and Environmental Medicine, Ludwig-Maximilians-University</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="08"><s1>Tartu University Clinics, Lung Clinic</s1>
<s2>Tartu</s2>
<s3>EST</s3>
<sZ>11 aut.</sZ>
</fA14>
<fA14 i1="09"><s1>Department of Epidemiology and Preventive Medicine, Monash University</s1>
<s2>VIC</s2>
<s3>AUS</s3>
<sZ>12 aut.</sZ>
</fA14>
<fA14 i1="10"><s1>Division of Occupational and Environmental Medicine, Department of Medicine, University of California San Francisco</s1>
<s2>San Francisco, CA</s2>
<s3>USA</s3>
<sZ>13 aut.</sZ>
</fA14>
<fA14 i1="11"><s1>Servizio Regionale di Epidemiologia</s1>
<s2>Turin</s2>
<s3>ITA</s3>
<sZ>15 aut.</sZ>
</fA14>
<fA14 i1="12"><s1>Institut National de Recherche et de Sécurité</s1>
<s2>Vandoeuvre -lès -Nancy</s2>
<s3>FRA</s3>
<sZ>16 aut.</sZ>
</fA14>
<fA14 i1="13"><s1>School of Occupational and Environmental Hygiene, University of British Columbia</s1>
<s2>Vancouver, BC</s2>
<s3>CAN</s3>
<sZ>17 aut.</sZ>
</fA14>
<fA14 i1="14"><s1>INSERM-The French Institute of Health and Medical Research, Unit 700-Epidemiology, Faculty of Medicine X Bichat</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>19 aut.</sZ>
</fA14>
<fA14 i1="15"><s1>Epidemiology Unit, Public Health Department of Bizkaia</s1>
<s2>Galolatao</s2>
<s3>ESP</s3>
<sZ>21 aut.</sZ>
</fA14>
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</fA20>
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</fA21>
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</fA66>
<fC01 i1="01" l="ENG"><s0>Background The role of exposure to substances in the workplace in new-onset asthma is not well characterised in population-based studies. We therefore aimed to estimate the relative and attributable risks of new-onset asthma in relation to occupations, work-related exposures, and inhalation accidents. Methods We studied prospectively 6837 participants from 13 countries who previously took part in the European Community Respiratory Health Survey (1990-95) and did not report respiratory symptoms or a history of asthma at the time of the first study. Asthma was assessed by methacholine challenge test and by questionnaire data on asthma symptoms. Exposures were defined by high-risk occupations, an asthma-specific job exposure matrix with additional expert judgment, and through self-report of acute inhalation events. Relative risks for new onset asthma were calculated with log-binomial models adjusted for age, sex, smoking, and study centre. Findings A significant excess asthma risk was seen after exposure to substances known to cause occupational asthma (Relative risk=1.6, 95% CI 1.1-2.3, p=0.017). Risks were highest for asthma defined by bronchial hyper-reactivity in addition to symptoms (2.4, 1.3-4.6, p=0.008). Of common occupations, a significant excess risk of asthma was seen for nursing (2.2, 1.3-4.0, p=0.007). Asthma risk was also increased in participants who reported an acute symptomatic inhalation event such as fire, mixing cleaning products, or chemical spills (RR=3.3, 95% CI 1.0-11.1, p=0.051). The population-attributable risk for adult asthma due to occupational exposures ranged from 10% to 25%, equivalent to an incidence of new-onset occupational asthma of 250-300 cases per million people per year. Interpretation Occupational exposures account for a substantial proportion of adult asthma incidence. The increased risk of asthma after inhalation accidents suggests that workers who have such accidents should be monitored closely.</s0>
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<s5>37</s5>
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<s5>37</s5>
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<s5>37</s5>
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<s5>38</s5>
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<s5>38</s5>
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<ET>Exposure to substances in the workplace and new-onset asthma : an international prospective population-based study (ECRHS-II). Commentary</ET>
<AU>MALO (Jean-Luc); GAUTRIN (Denyse); KOGEVINAS (Manolis); ZOCK (Jan-Paul); JARVIS (Debbie); KROMHOUT (Hans); LILLIENBERG (Linnéa); PLANA (Estel); RADON (Katja); TAREN (Kjell); ALLIKSOO (Ada); BENKE (Geza); BLANC (Paul D.); DAHLMAN-HOGLUND (Anna); D'ERRICO (Angelo); HERY (Michel); KENNEDY (Susan); KUNZLI (Nino); LEYNAERT (Bénédicte); MIRABELLI (Maria C.); MUNIOZGUREN (Nerea); NORBACK (Dan); OLIVIERI (Mario); PAYO (Félix); VILLANI (Simona); VAN SPRUNDEL (Marc); URRUTIA (Isabel); WIESLANDER (Gunilla); SUNYER (Jordi); ANTO (Josep M.)</AU>
<AF>Axe de recherche en santé respiratoire and Center for Asthma in the Workplace, Department of Chest Medicine, Sacré-Coeur Hospital/Montreal, H4J 1C5/Canada (1 aut., 2 aut.); Centre for Research in Environmental Epidemiology, Municipal Institute of Medical Research/Barcelona/Espagne (3 aut., 4 aut., 8 aut., 18 aut., 20 aut., 29 aut., 30 aut.); Medical School, University of Crete/Heraklion/Grèce (3 aut.); Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College/London/Royaume-Uni (5 aut.); Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University/Utrecht/Pays-Bas (6 aut.); Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital/Goteborg/Suède (7 aut., 10 aut., 14 aut.); Unit for Occupational and Environmental Epidemiology and NetTeaching, Institute for Occupational and Environmental Medicine, Ludwig-Maximilians-University/Munich/Allemagne (9 aut.); Tartu University Clinics, Lung Clinic/Tartu/Estonie (11 aut.); Department of Epidemiology and Preventive Medicine, Monash University/VIC/Australie (12 aut.); Division of Occupational and Environmental Medicine, Department of Medicine, University of California San Francisco/San Francisco, CA/Etats-Unis (13 aut.); Servizio Regionale di Epidemiologia/Turin/Italie (15 aut.); Institut National de Recherche et de Sécurité/Vandoeuvre -lès -Nancy/France (16 aut.); School of Occupational and Environmental Hygiene, University of British Columbia/Vancouver, BC/Canada (17 aut.); INSERM-The French Institute of Health and Medical Research, Unit 700-Epidemiology, Faculty of Medicine X Bichat/Paris/France (19 aut.); Epidemiology Unit, Public Health Department of Bizkaia/Galolatao/Espagne (21 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Lancet : (British edition); ISSN 0140-6736; Coden LANCAO; Royaume-Uni; Da. 2007; Vol. 370; No. 9584; 295-297, 336-341 [9 p.]; Bibl. 27 ref.</SO>
<LA>Anglais</LA>
<EA>Background The role of exposure to substances in the workplace in new-onset asthma is not well characterised in population-based studies. We therefore aimed to estimate the relative and attributable risks of new-onset asthma in relation to occupations, work-related exposures, and inhalation accidents. Methods We studied prospectively 6837 participants from 13 countries who previously took part in the European Community Respiratory Health Survey (1990-95) and did not report respiratory symptoms or a history of asthma at the time of the first study. Asthma was assessed by methacholine challenge test and by questionnaire data on asthma symptoms. Exposures were defined by high-risk occupations, an asthma-specific job exposure matrix with additional expert judgment, and through self-report of acute inhalation events. Relative risks for new onset asthma were calculated with log-binomial models adjusted for age, sex, smoking, and study centre. Findings A significant excess asthma risk was seen after exposure to substances known to cause occupational asthma (Relative risk=1.6, 95% CI 1.1-2.3, p=0.017). Risks were highest for asthma defined by bronchial hyper-reactivity in addition to symptoms (2.4, 1.3-4.6, p=0.008). Of common occupations, a significant excess risk of asthma was seen for nursing (2.2, 1.3-4.0, p=0.007). Asthma risk was also increased in participants who reported an acute symptomatic inhalation event such as fire, mixing cleaning products, or chemical spills (RR=3.3, 95% CI 1.0-11.1, p=0.051). The population-attributable risk for adult asthma due to occupational exposures ranged from 10% to 25%, equivalent to an incidence of new-onset occupational asthma of 250-300 cases per million people per year. Interpretation Occupational exposures account for a substantial proportion of adult asthma incidence. The increased risk of asthma after inhalation accidents suggests that workers who have such accidents should be monitored closely.</EA>
<CC>002B01; 002B30B04; 002B11B</CC>
<FD>Asthme; Exposition professionnelle; Stade précoce; International; Monde; Epidémiologie; Santé publique; Prospective; Population; Médecine</FD>
<FG>Appareil respiratoire pathologie; Bronchopneumopathie obstructive; Bronche pathologie; Poumon pathologie</FG>
<ED>Asthma; Occupational exposure; Early stage; International; World; Epidemiology; Public health; Prospective; Population; Medicine</ED>
<EG>Respiratory disease; Obstructive pulmonary disease; Bronchus disease; Lung disease</EG>
<SD>Asma; Exposición profesional; Estadio precoz; Internacional; Mundo; Epidemiología; Salud pública; Prospectiva; Población; Medicina</SD>
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Exposure to substances in the workplace and new-onset asthma : an international prospective population-based study (ECRHS-II). Commentary

Exposure to substances in the workplace and new-onset asthma : an international prospective population-based study (ECRHS-II). Commentary

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