A phase Ib trial of docetaxel, carboplatin and erlotinib in ovarian, fallopian tube and primary peritoneal cancers
Identifieur interne : 003459 ( PascalFrancis/Corpus ); précédent : 003458; suivant : 003460A phase Ib trial of docetaxel, carboplatin and erlotinib in ovarian, fallopian tube and primary peritoneal cancers
Auteurs : P. A. Vasey ; M. Gore ; R. Wilson ; G. Rustin ; H. Gabra ; J-P. Guastalla ; E. P. Lauraine ; J. Paul ; K. Carty ; S. KayeSource :
- British journal of cancer [ 0007-0920 ] ; 2008.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
The safety and maximum tolerated dose (MTD) of erlotinib with docetaxel/carboplatin were assessed in patients with ovarian cancer. Chemonaive patients received intravenous docetaxel (75 mg m-2) and carboplatin (area under the curve 5) on day I of a 3-week cycle, and oral erlotinib at 50 (cohort 1), 100 (cohort 2a) or 75 mg day-1 (cohort 2b) for up to six cycles. Dose-limiting toxicities were determined in cycle 1. Forty-five patients (median age 59 years) received treatment. Dose-limiting toxicities occurred in 1/5/5 patients (cohorts I /2a/2b). The MTD of erlotinib in this regimen was determined to be 75 mg day-1 (cohort 2b; the erlotinib dose was escalated to 100mg day-1 in I I out of 19 patients from cycle 2 onwards). Neutropaenia was the predominant grade 3/4 haematological toxicity (85/100/95% respectively). Common non-haematological toxicities were diarrhoea, fatigue, nausea and rash. There were five complete and seven partial responses in 23 evaluable patients (52% response rate). Docetaxel/carboplatin had no measurable effect on erlotinib pharmacokinetics. In subsequent single-agent maintenance, erlotinib was given at 100-150 mg day-1, with manageable toxicity, until tumour progression. Further investigation of erlotinib in epithelial ovarian carcinoma may be warranted, particularly as maintenance therapy.
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Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 08-0315574 INIST |
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ET : | A phase Ib trial of docetaxel, carboplatin and erlotinib in ovarian, fallopian tube and primary peritoneal cancers |
AU : | VASEY (P. A.); GORE (M.); WILSON (R.); RUSTIN (G.); GABRA (H.); GUASTALLA (J-P.); LAURAINE (E. P.); PAUL (J.); CARTY (K.); KAYE (S.) |
AF : | CR-UK Clinical Triais Unit, Beatson Oncology Centre, Western Infirmary, Dumbarton Road/Glasgow, Scotland GI 1 6NT/Royaume-Uni (1 aut., 8 aut., 9 aut.); Division of Medicine, University of Queensland/Brisbane Q4029/Australie (1 aut.); Royal Marsden Hospital, Fulham Road/London SW15 3SW/Royaume-Uni (2 aut.); Belfast City Hospital, Lisbum Road/Belfast, Ireland BT9 7AB/Royaume-Uni (3 aut.); Mount Vernon Hospital, Rickmansworth Road/Northwood, Hertfordshire HA6 2RN/Royaume-Uni (4 aut.); Western General Hospital, Crewe Road South/Edinburgh, Scotland EH4 2XU/Royaume-Uni (5 aut.); Centre Léon-Bérard, rue Laennec/69373, Lyon/France (6 aut.); Hopital de L'Hotel-Dieu, place du Parvis Notre-Dame/75181 Paris/France (7 aut.); Royal Marsden Hospital, Downs Road/Sutton, Surrey SM2 5PT/Royaume-Uni (10 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | British journal of cancer; ISSN 0007-0920; Coden BJCAAI; Royaume-Uni; Da. 2008; Vol. 98; No. 11; Pp. 1774-1780; Bibl. 1 p. |
LA : | Anglais |
EA : | The safety and maximum tolerated dose (MTD) of erlotinib with docetaxel/carboplatin were assessed in patients with ovarian cancer. Chemonaive patients received intravenous docetaxel (75 mg m-2) and carboplatin (area under the curve 5) on day I of a 3-week cycle, and oral erlotinib at 50 (cohort 1), 100 (cohort 2a) or 75 mg day-1 (cohort 2b) for up to six cycles. Dose-limiting toxicities were determined in cycle 1. Forty-five patients (median age 59 years) received treatment. Dose-limiting toxicities occurred in 1/5/5 patients (cohorts I /2a/2b). The MTD of erlotinib in this regimen was determined to be 75 mg day-1 (cohort 2b; the erlotinib dose was escalated to 100mg day-1 in I I out of 19 patients from cycle 2 onwards). Neutropaenia was the predominant grade 3/4 haematological toxicity (85/100/95% respectively). Common non-haematological toxicities were diarrhoea, fatigue, nausea and rash. There were five complete and seven partial responses in 23 evaluable patients (52% response rate). Docetaxel/carboplatin had no measurable effect on erlotinib pharmacokinetics. In subsequent single-agent maintenance, erlotinib was given at 100-150 mg day-1, with manageable toxicity, until tumour progression. Further investigation of erlotinib in epithelial ovarian carcinoma may be warranted, particularly as maintenance therapy. |
CC : | 002B04; 002B20C02 |
FD : | Docétaxel; Essai clinique; Ovaire; Carboplatine; Primaire; Péritoine; Erlotinib; Récepteur facteur croissance épiderme; Cancérologie; Cancer de la trompe de Fallope; Tumeur maligne; Anticancéreux |
FG : | Cancer; Antimitotique; Dérivé du taxane; Platine II Complexe; Inhibiteur enzyme; Dérivé de la quinazoline; Protein-tyrosine kinase; Transferases; Enzyme; Inhibiteur de la tyrosine kinase; Appareil génital femelle; Pathologie de l'appareil génital femelle; Pathologie de la trompe de Fallope |
ED : | Docetaxel; Clinical trial; Ovary; Carboplatin; Primary; Peritoneum; Erlotinib; Epidermal growth factor receptor; Cancerology; Fallopian tube cancer; Malignant tumor; Antineoplastic agent |
EG : | Cancer; Antimitotic; Taxane derivatives; Platinum II Complexes; Enzyme inhibitor; Quinazoline derivatives; Protein-tyrosine kinase; Transferases; Enzyme; Tyrosine kinase inhibitor; Female genital system; Female genital diseases; Fallopian tube pathology |
SD : | Docetaxel; Ensayo clínico; Ovario; Carboplatino; Primario; Peritoneo; Erlotinib; Receptor del factor de crecimiento epidérmico; Cancerología; Cáncer de falopio del tubo; Tumor maligno; Anticanceroso |
LO : | INIST-6925.354000198007140100 |
ID : | 08-0315574 |
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antineoplastic agent</term>
<term>Cancerology</term>
<term>Carboplatin</term>
<term>Clinical trial</term>
<term>Docetaxel</term>
<term>Epidermal growth factor receptor</term>
<term>Erlotinib</term>
<term>Fallopian tube cancer</term>
<term>Malignant tumor</term>
<term>Ovary</term>
<term>Peritoneum</term>
<term>Primary</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Docétaxel</term>
<term>Essai clinique</term>
<term>Ovaire</term>
<term>Carboplatine</term>
<term>Primaire</term>
<term>Péritoine</term>
<term>Erlotinib</term>
<term>Récepteur facteur croissance épiderme</term>
<term>Cancérologie</term>
<term>Cancer de la trompe de Fallope</term>
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<front><div type="abstract" xml:lang="en">The safety and maximum tolerated dose (MTD) of erlotinib with docetaxel/carboplatin were assessed in patients with ovarian cancer. Chemonaive patients received intravenous docetaxel (75 mg m<sup>-2</sup>
) and carboplatin (area under the curve 5) on day I of a 3-week cycle, and oral erlotinib at 50 (cohort 1), 100 (cohort 2a) or 75 mg day<sup>-1</sup>
(cohort 2b) for up to six cycles. Dose-limiting toxicities were determined in cycle 1. Forty-five patients (median age 59 years) received treatment. Dose-limiting toxicities occurred in 1/5/5 patients (cohorts I /2a/2b). The MTD of erlotinib in this regimen was determined to be 75 mg day<sup>-1</sup>
(cohort 2b; the erlotinib dose was escalated to 100mg day<sup>-1</sup>
in I I out of 19 patients from cycle 2 onwards). Neutropaenia was the predominant grade 3/4 haematological toxicity (85/100/95% respectively). Common non-haematological toxicities were diarrhoea, fatigue, nausea and rash. There were five complete and seven partial responses in 23 evaluable patients (52% response rate). Docetaxel/carboplatin had no measurable effect on erlotinib pharmacokinetics. In subsequent single-agent maintenance, erlotinib was given at 100-150 mg day<sup>-1</sup>
, with manageable toxicity, until tumour progression. Further investigation of erlotinib in epithelial ovarian carcinoma may be warranted, particularly as maintenance therapy.</div>
</front>
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<fA11 i1="01" i2="1"><s1>VASEY (P. A.)</s1>
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<fC01 i1="01" l="ENG"><s0>The safety and maximum tolerated dose (MTD) of erlotinib with docetaxel/carboplatin were assessed in patients with ovarian cancer. Chemonaive patients received intravenous docetaxel (75 mg m<sup>-2</sup>
) and carboplatin (area under the curve 5) on day I of a 3-week cycle, and oral erlotinib at 50 (cohort 1), 100 (cohort 2a) or 75 mg day<sup>-1</sup>
(cohort 2b) for up to six cycles. Dose-limiting toxicities were determined in cycle 1. Forty-five patients (median age 59 years) received treatment. Dose-limiting toxicities occurred in 1/5/5 patients (cohorts I /2a/2b). The MTD of erlotinib in this regimen was determined to be 75 mg day<sup>-1</sup>
(cohort 2b; the erlotinib dose was escalated to 100mg day<sup>-1</sup>
in I I out of 19 patients from cycle 2 onwards). Neutropaenia was the predominant grade 3/4 haematological toxicity (85/100/95% respectively). Common non-haematological toxicities were diarrhoea, fatigue, nausea and rash. There were five complete and seven partial responses in 23 evaluable patients (52% response rate). Docetaxel/carboplatin had no measurable effect on erlotinib pharmacokinetics. In subsequent single-agent maintenance, erlotinib was given at 100-150 mg day<sup>-1</sup>
, with manageable toxicity, until tumour progression. Further investigation of erlotinib in epithelial ovarian carcinoma may be warranted, particularly as maintenance therapy.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B04</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B20C02</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Docétaxel</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Docetaxel</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Docetaxel</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Essai clinique</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Clinical trial</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Ensayo clínico</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Ovaire</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Ovary</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Ovario</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Carboplatine</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Carboplatin</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Carboplatino</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Primaire</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Primary</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Primario</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Péritoine</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Peritoneum</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Peritoneo</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Erlotinib</s0>
<s2>FR</s2>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Erlotinib</s0>
<s2>FR</s2>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Erlotinib</s0>
<s2>FR</s2>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Récepteur facteur croissance épiderme</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Epidermal growth factor receptor</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Receptor del factor de crecimiento epidérmico</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Cancérologie</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Cancerology</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Cancerología</s0>
<s5>09</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Cancer de la trompe de Fallope</s0>
<s2>NM</s2>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Fallopian tube cancer</s0>
<s2>NM</s2>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Cáncer de falopio del tubo</s0>
<s2>NM</s2>
<s5>10</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Tumeur maligne</s0>
<s2>NM</s2>
<s5>13</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Malignant tumor</s0>
<s2>NM</s2>
<s5>13</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Tumor maligno</s0>
<s2>NM</s2>
<s5>13</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Anticancéreux</s0>
<s5>25</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Antineoplastic agent</s0>
<s5>25</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Anticanceroso</s0>
<s5>25</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Cancer</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Cancer</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Cáncer</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Antimitotique</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Antimitotic</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Antimitótico</s0>
<s5>37</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Dérivé du taxane</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Taxane derivatives</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Taxane derivado</s0>
<s5>38</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Platine II Complexe</s0>
<s2>NC</s2>
<s2>NA</s2>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Platinum II Complexes</s0>
<s2>NC</s2>
<s2>NA</s2>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Platino II Complejo</s0>
<s2>NC</s2>
<s2>NA</s2>
<s5>39</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Inhibiteur enzyme</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Enzyme inhibitor</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Inhibidor enzima</s0>
<s5>40</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Dérivé de la quinazoline</s0>
<s2>FR</s2>
<s5>41</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Quinazoline derivatives</s0>
<s2>FR</s2>
<s5>41</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Protein-tyrosine kinase</s0>
<s2>FE</s2>
<s5>42</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Protein-tyrosine kinase</s0>
<s2>FE</s2>
<s5>42</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Protein-tyrosine kinase</s0>
<s2>FE</s2>
<s5>42</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Transferases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Transferases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Transferases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Enzima</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="10" i2="X" l="FRE"><s0>Inhibiteur de la tyrosine kinase</s0>
<s5>43</s5>
</fC07>
<fC07 i1="10" i2="X" l="ENG"><s0>Tyrosine kinase inhibitor</s0>
<s5>43</s5>
</fC07>
<fC07 i1="10" i2="X" l="SPA"><s0>Inhibidor tyrosine kinase</s0>
<s5>43</s5>
</fC07>
<fC07 i1="11" i2="X" l="FRE"><s0>Appareil génital femelle</s0>
<s5>45</s5>
</fC07>
<fC07 i1="11" i2="X" l="ENG"><s0>Female genital system</s0>
<s5>45</s5>
</fC07>
<fC07 i1="11" i2="X" l="SPA"><s0>Aparato genital hembra</s0>
<s5>45</s5>
</fC07>
<fC07 i1="12" i2="X" l="FRE"><s0>Pathologie de l'appareil génital femelle</s0>
<s5>46</s5>
</fC07>
<fC07 i1="12" i2="X" l="ENG"><s0>Female genital diseases</s0>
<s5>46</s5>
</fC07>
<fC07 i1="12" i2="X" l="SPA"><s0>Aparato genital hembra patología</s0>
<s5>46</s5>
</fC07>
<fC07 i1="13" i2="X" l="FRE"><s0>Pathologie de la trompe de Fallope</s0>
<s5>47</s5>
</fC07>
<fC07 i1="13" i2="X" l="ENG"><s0>Fallopian tube pathology</s0>
<s5>47</s5>
</fC07>
<fC07 i1="13" i2="X" l="SPA"><s0>Trompa Falopio patología</s0>
<s5>47</s5>
</fC07>
<fN21><s1>196</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 08-0315574 INIST</NO>
<ET>A phase Ib trial of docetaxel, carboplatin and erlotinib in ovarian, fallopian tube and primary peritoneal cancers</ET>
<AU>VASEY (P. A.); GORE (M.); WILSON (R.); RUSTIN (G.); GABRA (H.); GUASTALLA (J-P.); LAURAINE (E. P.); PAUL (J.); CARTY (K.); KAYE (S.)</AU>
<AF>CR-UK Clinical Triais Unit, Beatson Oncology Centre, Western Infirmary, Dumbarton Road/Glasgow, Scotland GI 1 6NT/Royaume-Uni (1 aut., 8 aut., 9 aut.); Division of Medicine, University of Queensland/Brisbane Q4029/Australie (1 aut.); Royal Marsden Hospital, Fulham Road/London SW15 3SW/Royaume-Uni (2 aut.); Belfast City Hospital, Lisbum Road/Belfast, Ireland BT9 7AB/Royaume-Uni (3 aut.); Mount Vernon Hospital, Rickmansworth Road/Northwood, Hertfordshire HA6 2RN/Royaume-Uni (4 aut.); Western General Hospital, Crewe Road South/Edinburgh, Scotland EH4 2XU/Royaume-Uni (5 aut.); Centre Léon-Bérard, rue Laennec/69373, Lyon/France (6 aut.); Hopital de L'Hotel-Dieu, place du Parvis Notre-Dame/75181 Paris/France (7 aut.); Royal Marsden Hospital, Downs Road/Sutton, Surrey SM2 5PT/Royaume-Uni (10 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>British journal of cancer; ISSN 0007-0920; Coden BJCAAI; Royaume-Uni; Da. 2008; Vol. 98; No. 11; Pp. 1774-1780; Bibl. 1 p.</SO>
<LA>Anglais</LA>
<EA>The safety and maximum tolerated dose (MTD) of erlotinib with docetaxel/carboplatin were assessed in patients with ovarian cancer. Chemonaive patients received intravenous docetaxel (75 mg m<sup>-2</sup>
) and carboplatin (area under the curve 5) on day I of a 3-week cycle, and oral erlotinib at 50 (cohort 1), 100 (cohort 2a) or 75 mg day<sup>-1</sup>
(cohort 2b) for up to six cycles. Dose-limiting toxicities were determined in cycle 1. Forty-five patients (median age 59 years) received treatment. Dose-limiting toxicities occurred in 1/5/5 patients (cohorts I /2a/2b). The MTD of erlotinib in this regimen was determined to be 75 mg day<sup>-1</sup>
(cohort 2b; the erlotinib dose was escalated to 100mg day<sup>-1</sup>
in I I out of 19 patients from cycle 2 onwards). Neutropaenia was the predominant grade 3/4 haematological toxicity (85/100/95% respectively). Common non-haematological toxicities were diarrhoea, fatigue, nausea and rash. There were five complete and seven partial responses in 23 evaluable patients (52% response rate). Docetaxel/carboplatin had no measurable effect on erlotinib pharmacokinetics. In subsequent single-agent maintenance, erlotinib was given at 100-150 mg day<sup>-1</sup>
, with manageable toxicity, until tumour progression. Further investigation of erlotinib in epithelial ovarian carcinoma may be warranted, particularly as maintenance therapy.</EA>
<CC>002B04; 002B20C02</CC>
<FD>Docétaxel; Essai clinique; Ovaire; Carboplatine; Primaire; Péritoine; Erlotinib; Récepteur facteur croissance épiderme; Cancérologie; Cancer de la trompe de Fallope; Tumeur maligne; Anticancéreux</FD>
<FG>Cancer; Antimitotique; Dérivé du taxane; Platine II Complexe; Inhibiteur enzyme; Dérivé de la quinazoline; Protein-tyrosine kinase; Transferases; Enzyme; Inhibiteur de la tyrosine kinase; Appareil génital femelle; Pathologie de l'appareil génital femelle; Pathologie de la trompe de Fallope</FG>
<ED>Docetaxel; Clinical trial; Ovary; Carboplatin; Primary; Peritoneum; Erlotinib; Epidermal growth factor receptor; Cancerology; Fallopian tube cancer; Malignant tumor; Antineoplastic agent</ED>
<EG>Cancer; Antimitotic; Taxane derivatives; Platinum II Complexes; Enzyme inhibitor; Quinazoline derivatives; Protein-tyrosine kinase; Transferases; Enzyme; Tyrosine kinase inhibitor; Female genital system; Female genital diseases; Fallopian tube pathology</EG>
<SD>Docetaxel; Ensayo clínico; Ovario; Carboplatino; Primario; Peritoneo; Erlotinib; Receptor del factor de crecimiento epidérmico; Cancerología; Cáncer de falopio del tubo; Tumor maligno; Anticanceroso</SD>
<LO>INIST-6925.354000198007140100</LO>
<ID>08-0315574</ID>
</server>
</inist>
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