AustralieFrV1, PascalFrancis, Corpus, bibRecord, 003027

Is the ornithine transcarbamylase gene a genetic determinant of Alzheimer's disease?

Identifieur interne : 003027 ( PascalFrancis/Corpus ); précédent : 003026; suivant : 003028

Is the ornithine transcarbamylase gene a genetic determinant of Alzheimer's disease?

Auteurs : Franck Hansmannel ; Corinne Lendon ; Florence Pasquier ; Julie Dumont ; Didier Hannequin ; Julien Chapuis ; Geoffroy Laumet ; Anne-Marie Ayral ; Daniela Galimberti ; Elio Scarpini ; Dominique Campion ; Philippe Amouyel ; Jean-Charles Lambert

Source :

Neuroscience letters [ 0304-3940 ] ; 2009.

RBID : Pascal:09-0082051

Descripteurs français

Pascal (Inist)
- Ornithine carbamoyltransferase, Polymorphisme, Urée, Démence d'Alzheimer.

English descriptors

KwdEn :
- Alzheimer disease, Ornithine carbamoyltransferase, Polymorphism, Urea.

Abstract

Expression of ornithine transcarbamylase (OTC) is strongly induced in the brain of individuals suffering from Alzheimer's Disease (AD). Association studies in a population from northern France have revealed that two SNPs -389 G/A (rs5963409) and -241 A/G (rs5963411) located in the promoter of the OTC gene are associated with the risk of developing AD. In the present work, these association studies were extended to a population of 2113 AD cases and 1580 controls from northern France, western France, the United Kingdom and Italy. The rs5963409 minor allele was weakly but significantly associated with an increased risk of developing AD (OR = 1.19, p = 0.004). This association was independent of age and ApoE status. Our results support that the OTC gene may be a minor genetic determinant of AD.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0304-3940`
A02	`01`			`@0 NELED5`
A03		`1`		`@0 Neurosci. lett.`
A05				`@2 449`
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A08	`01`	`1`	`ENG`	`@1 Is the ornithine transcarbamylase gene a genetic determinant of Alzheimer's disease?`
A11	`01`	`1`		`@1 HANSMANNEL (Franck)`
A11	`02`	`1`		`@1 LENDON (Corinne)`
A11	`03`	`1`		`@1 PASQUIER (Florence)`
A11	`04`	`1`		`@1 DUMONT (Julie)`
A11	`05`	`1`		`@1 HANNEQUIN (Didier)`
A11	`06`	`1`		`@1 CHAPUIS (Julien)`
A11	`07`	`1`		`@1 LAUMET (Geoffroy)`
A11	`08`	`1`		`@1 AYRAL (Anne-Marie)`
A11	`09`	`1`		`@1 GALIMBERTI (Daniela)`
A11	`10`	`1`		`@1 SCARPINI (Elio)`
A11	`11`	`1`		`@1 CAMPION (Dominique)`
A11	`12`	`1`		`@1 AMOUYEL (Philippe)`
A11	`13`	`1`		`@1 LAMBERT (Jean-Charles)`
A14	`01`			`@1 INSERM, U744, Institut Pasteur de Lille, Université de Lille @2 Lille @3 FRA @Z 1 aut. @Z 4 aut. @Z 6 aut. @Z 7 aut. @Z 8 aut. @Z 12 aut. @Z 13 aut.`
A14	`02`			`@1 Molecular Psychiatry Group, Queensland Institute of Medical Research @2 Brisbane @3 AUS @Z 2 aut.`
A14	`03`			`@1 EA2391, Department of Neurology, Memory Clinic, University Hospital of Lille @3 FRA @Z 3 aut.`
A14	`04`			`@1 INSERM U614, Faculty of Medicine of Rouen @3 FRA @Z 5 aut. @Z 11 aut.`
A14	`05`			`@1 Department of Neurological Sciences, University of Milan, Fondazione Ospedale Maggiore Policlinico @2 Milan @3 ITA @Z 9 aut. @Z 10 aut.`
A20				`@1 76-80`
A21				`@1 2009`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 17240 @5 354000185030790170`
A44				`@0 0000 @1 © 2009 INIST-CNRS. All rights reserved.`
A45				`@0 12 ref.`
A47	`01`	`1`		`@0 09-0082051`
A60				`@1 P @3 PR`
A61				`@0 A`
A64	`01`	`1`		`@0 Neuroscience letters`
A66	`01`			`@0 IRL`
C01	`01`		`ENG`	@0 Expression of ornithine transcarbamylase (OTC) is strongly induced in the brain of individuals suffering from Alzheimer's Disease (AD). Association studies in a population from northern France have revealed that two SNPs -389 G/A (rs5963409) and -241 A/G (rs5963411) located in the promoter of the OTC gene are associated with the risk of developing AD. In the present work, these association studies were extended to a population of 2113 AD cases and 1580 controls from northern France, western France, the United Kingdom and Italy. The rs5963409 minor allele was weakly but significantly associated with an increased risk of developing AD (OR = 1.19, p = 0.004). This association was independent of age and ApoE status. Our results support that the OTC gene may be a minor genetic determinant of AD.
C02	`01`	`X`		`@0 002A25`
C02	`02`	`X`		`@0 002B17G`
C03	`01`	`X`	`FRE`	`@0 Ornithine carbamoyltransferase @2 FE @5 01`
C03	`01`	`X`	`ENG`	`@0 Ornithine carbamoyltransferase @2 FE @5 01`
C03	`01`	`X`	`SPA`	`@0 Ornithine carbamoyltransferase @2 FE @5 01`
C03	`02`	`X`	`FRE`	`@0 Polymorphisme @5 02`
C03	`02`	`X`	`ENG`	`@0 Polymorphism @5 02`
C03	`02`	`X`	`SPA`	`@0 Polimorfismo @5 02`
C03	`03`	`X`	`FRE`	`@0 Urée @2 NK @2 FR @5 03`
C03	`03`	`X`	`ENG`	`@0 Urea @2 NK @2 FR @5 03`
C03	`03`	`X`	`SPA`	`@0 Urea @2 NK @2 FR @5 03`
C03	`04`	`X`	`FRE`	`@0 Démence d'Alzheimer @5 09`
C03	`04`	`X`	`ENG`	`@0 Alzheimer disease @5 09`
C03	`04`	`X`	`SPA`	`@0 Demencia Alzheimer @5 09`
C07	`01`	`X`	`FRE`	`@0 Transferases @2 FE`
C07	`01`	`X`	`ENG`	`@0 Transferases @2 FE`
C07	`01`	`X`	`SPA`	`@0 Transferases @2 FE`
C07	`02`	`X`	`FRE`	`@0 Enzyme @2 FE`
C07	`02`	`X`	`ENG`	`@0 Enzyme @2 FE`
C07	`02`	`X`	`SPA`	`@0 Enzima @2 FE`
C07	`03`	`X`	`FRE`	`@0 Maladie dégénérative @5 20`
C07	`03`	`X`	`ENG`	`@0 Degenerative disease @5 20`
C07	`03`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 20`
C07	`04`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 21`
C07	`04`	`X`	`ENG`	`@0 Nervous system diseases @5 21`
C07	`04`	`X`	`SPA`	`@0 Sistema nervioso patología @5 21`
C07	`05`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 22`
C07	`05`	`X`	`ENG`	`@0 Cerebral disorder @5 22`
C07	`05`	`X`	`SPA`	`@0 Encéfalo patología @5 22`
C07	`06`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 23`
C07	`06`	`X`	`ENG`	`@0 Central nervous system disease @5 23`
C07	`06`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 23`
N21				`@1 061`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 09-0082051 INIST
ET :	Is the ornithine transcarbamylase gene a genetic determinant of Alzheimer's disease?
AU :	HANSMANNEL (Franck); LENDON (Corinne); PASQUIER (Florence); DUMONT (Julie); HANNEQUIN (Didier); CHAPUIS (Julien); LAUMET (Geoffroy); AYRAL (Anne-Marie); GALIMBERTI (Daniela); SCARPINI (Elio); CAMPION (Dominique); AMOUYEL (Philippe); LAMBERT (Jean-Charles)
AF :	INSERM, U744, Institut Pasteur de Lille, Université de Lille/Lille/France (1 aut., 4 aut., 6 aut., 7 aut., 8 aut., 12 aut., 13 aut.); Molecular Psychiatry Group, Queensland Institute of Medical Research/Brisbane/Australie (2 aut.); EA2391, Department of Neurology, Memory Clinic, University Hospital of Lille/France (3 aut.); INSERM U614, Faculty of Medicine of Rouen/France (5 aut., 11 aut.); Department of Neurological Sciences, University of Milan, Fondazione Ospedale Maggiore Policlinico/Milan/Italie (9 aut., 10 aut.)
DT :	Publication en série; Papier de recherche; Niveau analytique
SO :	Neuroscience letters; ISSN 0304-3940; Coden NELED5; Irlande; Da. 2009; Vol. 449; No. 1; Pp. 76-80; Bibl. 12 ref.
LA :	Anglais
EA :	Expression of ornithine transcarbamylase (OTC) is strongly induced in the brain of individuals suffering from Alzheimer's Disease (AD). Association studies in a population from northern France have revealed that two SNPs -389 G/A (rs5963409) and -241 A/G (rs5963411) located in the promoter of the OTC gene are associated with the risk of developing AD. In the present work, these association studies were extended to a population of 2113 AD cases and 1580 controls from northern France, western France, the United Kingdom and Italy. The rs5963409 minor allele was weakly but significantly associated with an increased risk of developing AD (OR = 1.19, p = 0.004). This association was independent of age and ApoE status. Our results support that the OTC gene may be a minor genetic determinant of AD.
CC :	002A25; 002B17G
FD :	Ornithine carbamoyltransferase; Polymorphisme; Urée; Démence d'Alzheimer
FG :	Transferases; Enzyme; Maladie dégénérative; Pathologie du système nerveux; Pathologie de l'encéphale; Pathologie du système nerveux central
ED :	Ornithine carbamoyltransferase; Polymorphism; Urea; Alzheimer disease
EG :	Transferases; Enzyme; Degenerative disease; Nervous system diseases; Cerebral disorder; Central nervous system disease
SD :	Ornithine carbamoyltransferase; Polimorfismo; Urea; Demencia Alzheimer
LO :	INIST-17240.354000185030790170
ID :	09-0082051

Links to Exploration step

Pascal:09-0082051

Le document en format XML

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<author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Is the ornithine transcarbamylase gene a genetic determinant of Alzheimer's disease?</title>
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<author><name sortKey="Dumont, Julie" sort="Dumont, Julie" uniqKey="Dumont J" first="Julie" last="Dumont">Julie Dumont</name>
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<author><name sortKey="Laumet, Geoffroy" sort="Laumet, Geoffroy" uniqKey="Laumet G" first="Geoffroy" last="Laumet">Geoffroy Laumet</name>
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<author><name sortKey="Ayral, Anne Marie" sort="Ayral, Anne Marie" uniqKey="Ayral A" first="Anne-Marie" last="Ayral">Anne-Marie Ayral</name>
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<author><name sortKey="Galimberti, Daniela" sort="Galimberti, Daniela" uniqKey="Galimberti D" first="Daniela" last="Galimberti">Daniela Galimberti</name>
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<author><name sortKey="Scarpini, Elio" sort="Scarpini, Elio" uniqKey="Scarpini E" first="Elio" last="Scarpini">Elio Scarpini</name>
<affiliation><inist:fA14 i1="05"><s1>Department of Neurological Sciences, University of Milan, Fondazione Ospedale Maggiore Policlinico</s1>
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<author><name sortKey="Campion, Dominique" sort="Campion, Dominique" uniqKey="Campion D" first="Dominique" last="Campion">Dominique Campion</name>
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<author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
<affiliation><inist:fA14 i1="01"><s1>INSERM, U744, Institut Pasteur de Lille, Université de Lille</s1>
<s2>Lille</s2>
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<author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name>
<affiliation><inist:fA14 i1="01"><s1>INSERM, U744, Institut Pasteur de Lille, Université de Lille</s1>
<s2>Lille</s2>
<s3>FRA</s3>
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<series><title level="j" type="main">Neuroscience letters</title>
<title level="j" type="abbreviated">Neurosci. lett.</title>
<idno type="ISSN">0304-3940</idno>
<imprint><date when="2009">2009</date>
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<seriesStmt><title level="j" type="main">Neuroscience letters</title>
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<idno type="ISSN">0304-3940</idno>
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<term>Ornithine carbamoyltransferase</term>
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<term>Urea</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Ornithine carbamoyltransferase</term>
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<front><div type="abstract" xml:lang="en">Expression of ornithine transcarbamylase (OTC) is strongly induced in the brain of individuals suffering from Alzheimer's Disease (AD). Association studies in a population from northern France have revealed that two SNPs -389 G/A (rs5963409) and -241 A/G (rs5963411) located in the promoter of the OTC gene are associated with the risk of developing AD. In the present work, these association studies were extended to a population of 2113 AD cases and 1580 controls from northern France, western France, the United Kingdom and Italy. The rs5963409 minor allele was weakly but significantly associated with an increased risk of developing AD (OR = 1.19, p = 0.004). This association was independent of age and ApoE status. Our results support that the OTC gene may be a minor genetic determinant of AD.</div>
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<fA14 i1="02"><s1>Molecular Psychiatry Group, Queensland Institute of Medical Research</s1>
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<fA14 i1="05"><s1>Department of Neurological Sciences, University of Milan, Fondazione Ospedale Maggiore Policlinico</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
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<server><NO>PASCAL 09-0082051 INIST</NO>
<ET>Is the ornithine transcarbamylase gene a genetic determinant of Alzheimer's disease?</ET>
<AU>HANSMANNEL (Franck); LENDON (Corinne); PASQUIER (Florence); DUMONT (Julie); HANNEQUIN (Didier); CHAPUIS (Julien); LAUMET (Geoffroy); AYRAL (Anne-Marie); GALIMBERTI (Daniela); SCARPINI (Elio); CAMPION (Dominique); AMOUYEL (Philippe); LAMBERT (Jean-Charles)</AU>
<AF>INSERM, U744, Institut Pasteur de Lille, Université de Lille/Lille/France (1 aut., 4 aut., 6 aut., 7 aut., 8 aut., 12 aut., 13 aut.); Molecular Psychiatry Group, Queensland Institute of Medical Research/Brisbane/Australie (2 aut.); EA2391, Department of Neurology, Memory Clinic, University Hospital of Lille/France (3 aut.); INSERM U614, Faculty of Medicine of Rouen/France (5 aut., 11 aut.); Department of Neurological Sciences, University of Milan, Fondazione Ospedale Maggiore Policlinico/Milan/Italie (9 aut., 10 aut.)</AF>
<DT>Publication en série; Papier de recherche; Niveau analytique</DT>
<SO>Neuroscience letters; ISSN 0304-3940; Coden NELED5; Irlande; Da. 2009; Vol. 449; No. 1; Pp. 76-80; Bibl. 12 ref.</SO>
<LA>Anglais</LA>
<EA>Expression of ornithine transcarbamylase (OTC) is strongly induced in the brain of individuals suffering from Alzheimer's Disease (AD). Association studies in a population from northern France have revealed that two SNPs -389 G/A (rs5963409) and -241 A/G (rs5963411) located in the promoter of the OTC gene are associated with the risk of developing AD. In the present work, these association studies were extended to a population of 2113 AD cases and 1580 controls from northern France, western France, the United Kingdom and Italy. The rs5963409 minor allele was weakly but significantly associated with an increased risk of developing AD (OR = 1.19, p = 0.004). This association was independent of age and ApoE status. Our results support that the OTC gene may be a minor genetic determinant of AD.</EA>
<CC>002A25; 002B17G</CC>
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<ED>Ornithine carbamoyltransferase; Polymorphism; Urea; Alzheimer disease</ED>
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Is the ornithine transcarbamylase gene a genetic determinant of Alzheimer's disease?

Is the ornithine transcarbamylase gene a genetic determinant of Alzheimer's disease?

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