AustralieFrV1, PascalFrancis, Corpus, bibRecord, 002B95

A Population-Based Study of Australian Twins with Melanoma Suggests a Strong Genetic Contribution to Liability

Identifieur interne : 002B95 ( PascalFrancis/Corpus ); précédent : 002B94; suivant : 002B96

A Population-Based Study of Australian Twins with Melanoma Suggests a Strong Genetic Contribution to Liability

Auteurs : Sri N. Shekar ; David L. Duffy ; Philippa Youl ; Amanda J. Baxter ; Marina Kvaskoff ; David C. Whiteman ; Adèle C. Green ; Maria C. Hughes ; Nicholas K. Hayward ; Marylon Coates ; Nicholas G. Martin

Source :

Journal of investigative dermatology [ 0022-202X ] ; 2009.

RBID : Pascal:09-0384984

Descripteurs français

Pascal (Inist)
- Mélanome malin, Australie, Jumeau, Dermatologie.

English descriptors

KwdEn :
- Australia, Dermatology, Malignant melanoma, Twin.

Abstract

Melanoma runs within families, but this may be due to either shared genetic or shared environmental influences within those families. The concordance between pairs of non-identical twins compared to that between identical twins can be used to determine whether familial aggregation is due to genetic or environmental factors. Mandatory reporting of melanoma cases in the state of Queensland yielded approximately 12,000 cases between 1982 and 1990. Twins in this study and from the adjacent state of New South Wales (125 pairs in total) were used to partition variation in liability to melanoma into genetic and environmental factors. Identical twins were more concordant for melanoma (4 of 27 pairs) than non-identical twins (3 of 98 pairs; P-value≃0.04). Identical co-twins of affected individuals were 9.8 times more likely to be affected than by chance. However, non-identical co-twins of affected individuals were only 1.8 times more likely to be affected than by chance. An MZ:DZ recurrence risk ratio of 5.6 suggests that some of the genetic influences on melanoma are due to epistatic (gene-gene) interactions. Using these data and population prevalences, it was estimated that 55% of the variation in liability to melanoma is due to genetic influences.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A08	`01`	`1`	`ENG`	`@1 A Population-Based Study of Australian Twins with Melanoma Suggests a Strong Genetic Contribution to Liability`
A11	`01`	`1`		`@1 SHEKAR (Sri N.)`
A11	`02`	`1`		`@1 DUFFY (David L.)`
A11	`03`	`1`		`@1 YOUL (Philippa)`
A11	`04`	`1`		`@1 BAXTER (Amanda J.)`
A11	`05`	`1`		`@1 KVASKOFF (Marina)`
A11	`06`	`1`		`@1 WHITEMAN (David C.)`
A11	`07`	`1`		`@1 GREEN (Adèle C.)`
A11	`08`	`1`		`@1 HUGHES (Maria C.)`
A11	`09`	`1`		`@1 HAYWARD (Nicholas K.)`
A11	`10`	`1`		`@1 COATES (Marylon)`
A11	`11`	`1`		`@1 MARTIN (Nicholas G.)`
A14	`01`			`@1 Queensland Institute of Medical Research @2 Brisbane, Queensland @3 AUS @Z 1 aut. @Z 2 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut. @Z 7 aut. @Z 8 aut. @Z 9 aut. @Z 11 aut.`
A14	`02`			`@1 School of Medicine, University of Queensland @2 Brisbane, Queensland @3 AUS @Z 1 aut.`
A14	`03`			`@1 The Cancer Council Queensland @2 Brisbane, Queensland @3 AUS @Z 3 aut.`
A14	`04`			`@1 Inserm, (Institut National de la Santé et de la Recherche Médicale) @2 Villejuif @3 FRA @Z 5 aut.`
A14	`05`			`@1 Institut Gustave Roussy Villejuif @3 FRA @Z 5 aut.`
A14	`06`			`@1 The NSW Central Cancer Registry @2 Sydney, New South Wales @3 AUS @Z 10 aut.`
A20				`@1 2211-2219`
A21				`@1 2009`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 3194 @5 354000171842930190`
A44				`@0 0000 @1 © 2009 INIST-CNRS. All rights reserved.`
A45				`@0 3/4 p.`
A47	`01`	`1`		`@0 09-0384984`
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A61				`@0 A`
A64	`01`	`1`		`@0 Journal of investigative dermatology`
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C01	`01`		`ENG`	@0 Melanoma runs within families, but this may be due to either shared genetic or shared environmental influences within those families. The concordance between pairs of non-identical twins compared to that between identical twins can be used to determine whether familial aggregation is due to genetic or environmental factors. Mandatory reporting of melanoma cases in the state of Queensland yielded approximately 12,000 cases between 1982 and 1990. Twins in this study and from the adjacent state of New South Wales (125 pairs in total) were used to partition variation in liability to melanoma into genetic and environmental factors. Identical twins were more concordant for melanoma (4 of 27 pairs) than non-identical twins (3 of 98 pairs; P-value≃0.04). Identical co-twins of affected individuals were 9.8 times more likely to be affected than by chance. However, non-identical co-twins of affected individuals were only 1.8 times more likely to be affected than by chance. An MZ:DZ recurrence risk ratio of 5.6 suggests that some of the genetic influences on melanoma are due to epistatic (gene-gene) interactions. Using these data and population prevalences, it was estimated that 55% of the variation in liability to melanoma is due to genetic influences.
C02	`01`	`X`		`@0 002B08A`
C03	`01`	`X`	`FRE`	`@0 Mélanome malin @5 01`
C03	`01`	`X`	`ENG`	`@0 Malignant melanoma @5 01`
C03	`01`	`X`	`SPA`	`@0 Melanoma maligno @5 01`
C03	`02`	`X`	`FRE`	`@0 Australie @2 NG @5 07`
C03	`02`	`X`	`ENG`	`@0 Australia @2 NG @5 07`
C03	`02`	`X`	`SPA`	`@0 Australia @2 NG @5 07`
C03	`03`	`X`	`FRE`	`@0 Jumeau @5 08`
C03	`03`	`X`	`ENG`	`@0 Twin @5 08`
C03	`03`	`X`	`SPA`	`@0 Gemelo @5 08`
C03	`04`	`X`	`FRE`	`@0 Dermatologie @5 09`
C03	`04`	`X`	`ENG`	`@0 Dermatology @5 09`
C03	`04`	`X`	`SPA`	`@0 Dermatología @5 09`
C07	`01`	`X`	`FRE`	`@0 Océanie @2 NG`
C07	`01`	`X`	`ENG`	`@0 Oceania @2 NG`
C07	`01`	`X`	`SPA`	`@0 Oceania @2 NG`
C07	`02`	`X`	`FRE`	`@0 Tumeur maligne @2 NM @5 37`
C07	`02`	`X`	`ENG`	`@0 Malignant tumor @2 NM @5 37`
C07	`02`	`X`	`SPA`	`@0 Tumor maligno @2 NM @5 37`
C07	`03`	`X`	`FRE`	`@0 Cancer @2 NM`
C07	`03`	`X`	`ENG`	`@0 Cancer @2 NM`
C07	`03`	`X`	`SPA`	`@0 Cáncer @2 NM`
N21				`@1 278`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 09-0384984 INIST
ET :	A Population-Based Study of Australian Twins with Melanoma Suggests a Strong Genetic Contribution to Liability
AU :	SHEKAR (Sri N.); DUFFY (David L.); YOUL (Philippa); BAXTER (Amanda J.); KVASKOFF (Marina); WHITEMAN (David C.); GREEN (Adèle C.); HUGHES (Maria C.); HAYWARD (Nicholas K.); COATES (Marylon); MARTIN (Nicholas G.)
AF :	Queensland Institute of Medical Research/Brisbane, Queensland/Australie (1 aut., 2 aut., 4 aut., 5 aut., 6 aut., 7 aut., 8 aut., 9 aut., 11 aut.); School of Medicine, University of Queensland/Brisbane, Queensland/Australie (1 aut.); The Cancer Council Queensland/Brisbane, Queensland/Australie (3 aut.); Inserm, (Institut National de la Santé et de la Recherche Médicale)/Villejuif/France (5 aut.); Institut Gustave Roussy Villejuif/France (5 aut.); The NSW Central Cancer Registry/Sydney, New South Wales/Australie (10 aut.)
DT :	Publication en série; Niveau analytique
SO :	Journal of investigative dermatology; ISSN 0022-202X; Coden JIDEAE; Etats-Unis; Da. 2009; Vol. 129; No. 9; Pp. 2211-2219; Bibl. 3/4 p.
LA :	Anglais
EA :	Melanoma runs within families, but this may be due to either shared genetic or shared environmental influences within those families. The concordance between pairs of non-identical twins compared to that between identical twins can be used to determine whether familial aggregation is due to genetic or environmental factors. Mandatory reporting of melanoma cases in the state of Queensland yielded approximately 12,000 cases between 1982 and 1990. Twins in this study and from the adjacent state of New South Wales (125 pairs in total) were used to partition variation in liability to melanoma into genetic and environmental factors. Identical twins were more concordant for melanoma (4 of 27 pairs) than non-identical twins (3 of 98 pairs; P-value≃0.04). Identical co-twins of affected individuals were 9.8 times more likely to be affected than by chance. However, non-identical co-twins of affected individuals were only 1.8 times more likely to be affected than by chance. An MZ:DZ recurrence risk ratio of 5.6 suggests that some of the genetic influences on melanoma are due to epistatic (gene-gene) interactions. Using these data and population prevalences, it was estimated that 55% of the variation in liability to melanoma is due to genetic influences.
CC :	002B08A
FD :	Mélanome malin; Australie; Jumeau; Dermatologie
FG :	Océanie; Tumeur maligne; Cancer
ED :	Malignant melanoma; Australia; Twin; Dermatology
EG :	Oceania; Malignant tumor; Cancer
SD :	Melanoma maligno; Australia; Gemelo; Dermatología
LO :	INIST-3194.354000171842930190
ID :	09-0384984

Links to Exploration step

Pascal:09-0384984

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">A Population-Based Study of Australian Twins with Melanoma Suggests a Strong Genetic Contribution to Liability</title>
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<front><div type="abstract" xml:lang="en">Melanoma runs within families, but this may be due to either shared genetic or shared environmental influences within those families. The concordance between pairs of non-identical twins compared to that between identical twins can be used to determine whether familial aggregation is due to genetic or environmental factors. Mandatory reporting of melanoma cases in the state of Queensland yielded approximately 12,000 cases between 1982 and 1990. Twins in this study and from the adjacent state of New South Wales (125 pairs in total) were used to partition variation in liability to melanoma into genetic and environmental factors. Identical twins were more concordant for melanoma (4 of 27 pairs) than non-identical twins (3 of 98 pairs; P-value≃0.04). Identical co-twins of affected individuals were 9.8 times more likely to be affected than by chance. However, non-identical co-twins of affected individuals were only 1.8 times more likely to be affected than by chance. An MZ:DZ recurrence risk ratio of 5.6 suggests that some of the genetic influences on melanoma are due to epistatic (gene-gene) interactions. Using these data and population prevalences, it was estimated that 55% of the variation in liability to melanoma is due to genetic influences.</div>
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<ET>A Population-Based Study of Australian Twins with Melanoma Suggests a Strong Genetic Contribution to Liability</ET>
<AU>SHEKAR (Sri N.); DUFFY (David L.); YOUL (Philippa); BAXTER (Amanda J.); KVASKOFF (Marina); WHITEMAN (David C.); GREEN (Adèle C.); HUGHES (Maria C.); HAYWARD (Nicholas K.); COATES (Marylon); MARTIN (Nicholas G.)</AU>
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A Population-Based Study of Australian Twins with Melanoma Suggests a Strong Genetic Contribution to Liability

A Population-Based Study of Australian Twins with Melanoma Suggests a Strong Genetic Contribution to Liability

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