Management of behavioral problems in Alzheimer's disease
Identifieur interne : 002A17 ( PascalFrancis/Corpus ); précédent : 002A16; suivant : 002A18Management of behavioral problems in Alzheimer's disease
Auteurs : Serge Gauthier ; Jeffrey Cummings ; Clive Ballard ; Henry Brodaty ; George Grossberg ; Philippe Robert ; Constantine LyketsosSource :
- International psychogeriatrics [ 1041-6102 ] ; 2010.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Alzheimer's disease (AD) is a complex progressive brain degenerative disorder that has effects on multiple cerebral systems. In addition to cognitive and functional decline, diverse behavioral changes manifest with increasing severity over time, presenting significant management challenges for caregivers and health care professionals. Almost all patients with AD are affected by neuropsychiatric symptoms at some point during their illness; in some cases, symptoms occur prior to diagnosis of the dementia syndrome. Further, behavioral factors have been identified, which may have their origins in particular neurobiological processes, and respond to particular management strategies. Improved clarification of causes, triggers, and presentation of neuropsychiatric symptoms will guide both research and clinical decision-making. Measurement of neuropsychiatric symptoms in AD is most commonly by means of the Neuropsychiatric Inventory; its utility and future development are discussed, as are the limitations and difficulties encountered when quantifying behavioral responses in clinical trials. Evidence from clinical trials of both non-pharmacological and pharmacological treatments, and from neurobiological studies, provides a range of management options that can be tailored to individual needs. We suggest that non-pharmacological interventions (including psychosocial/psychological counseling, interpersonal management and environmental management) should be attempted first, followed by the least harmful medication for the shortest time possible. Pharmacological treatment options, such as antipsychotics, antidepressants, anticonvulsants, cholinesterase inhibitors and memantine, need careful consideration of the benefits and limitations of each drug class.
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | FRANCIS 10-0266370 INIST |
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ET : | Management of behavioral problems in Alzheimer's disease |
AU : | GAUTHIER (Serge); CUMMINGS (Jeffrey); BALLARD (Clive); BRODATY (Henry); GROSSBERG (George); ROBERT (Philippe); LYKETSOS (Constantine) |
AF : | Alzheimer's Disease and Related Disorders Unit at the McGill Centerfor Studies in Aging Douglas Mental Health University Institute/Montreal/Canada (1 aut.); Mary S. Easton Center for Alzheimer's Disease Research at UCLA/Los Angeles, California/Etats-Unis (2 aut.); Age Related Diseases, King's College London/London/Royaume-Uni (3 aut.); Primary Dementia Collaborative Research Centre, School of Psychiatry, University of New South Wales/Sydney/Australie (4 aut.); Department of Neurology and Psychiatry, St Louis University School of Medicine/St Louis, Missouri/Etats-Unis (5 aut.); Centre Mémoire de Ressources et de Recherche (Memory Centre for Care and Research), CHU de Nice, Hôpital Pasteur/Nice/France (6 aut.); Department of Psychiatry, The Johns Hopkins Bayview Medical Center/Baltimore, Maryland/Etats-Unis (7 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | International psychogeriatrics; ISSN 1041-6102; Etats-Unis; Da. 2010; Vol. 22; No. 3; Pp. 346-372; Bibl. 7 p. |
LA : | Anglais |
EA : | Alzheimer's disease (AD) is a complex progressive brain degenerative disorder that has effects on multiple cerebral systems. In addition to cognitive and functional decline, diverse behavioral changes manifest with increasing severity over time, presenting significant management challenges for caregivers and health care professionals. Almost all patients with AD are affected by neuropsychiatric symptoms at some point during their illness; in some cases, symptoms occur prior to diagnosis of the dementia syndrome. Further, behavioral factors have been identified, which may have their origins in particular neurobiological processes, and respond to particular management strategies. Improved clarification of causes, triggers, and presentation of neuropsychiatric symptoms will guide both research and clinical decision-making. Measurement of neuropsychiatric symptoms in AD is most commonly by means of the Neuropsychiatric Inventory; its utility and future development are discussed, as are the limitations and difficulties encountered when quantifying behavioral responses in clinical trials. Evidence from clinical trials of both non-pharmacological and pharmacological treatments, and from neurobiological studies, provides a range of management options that can be tailored to individual needs. We suggest that non-pharmacological interventions (including psychosocial/psychological counseling, interpersonal management and environmental management) should be attempted first, followed by the least harmful medication for the shortest time possible. Pharmacological treatment options, such as antipsychotics, antidepressants, anticonvulsants, cholinesterase inhibitors and memantine, need careful consideration of the benefits and limitations of each drug class. |
CC : | 770D05; 770D03M |
FD : | Gestion; Trouble du comportement; Démence d'Alzheimer; Comportement; Traitement; Personne âgée |
FG : | Homme; Pathologie de l'encéphale; Maladie dégénérative; Pathologie du système nerveux central; Pathologie du système nerveux |
ED : | Management; Behavioral disorder; Alzheimer disease; Behavior; Treatment; Elderly |
EG : | Human; Cerebral disorder; Degenerative disease; Central nervous system disease; Nervous system diseases |
SD : | Gestión; Trastorno conducta; Demencia Alzheimer; Conducta; Tratamiento; Anciano |
LO : | INIST-26959.354000181144060020 |
ID : | 10-0266370 |
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<front><div type="abstract" xml:lang="en">Alzheimer's disease (AD) is a complex progressive brain degenerative disorder that has effects on multiple cerebral systems. In addition to cognitive and functional decline, diverse behavioral changes manifest with increasing severity over time, presenting significant management challenges for caregivers and health care professionals. Almost all patients with AD are affected by neuropsychiatric symptoms at some point during their illness; in some cases, symptoms occur prior to diagnosis of the dementia syndrome. Further, behavioral factors have been identified, which may have their origins in particular neurobiological processes, and respond to particular management strategies. Improved clarification of causes, triggers, and presentation of neuropsychiatric symptoms will guide both research and clinical decision-making. Measurement of neuropsychiatric symptoms in AD is most commonly by means of the Neuropsychiatric Inventory; its utility and future development are discussed, as are the limitations and difficulties encountered when quantifying behavioral responses in clinical trials. Evidence from clinical trials of both non-pharmacological and pharmacological treatments, and from neurobiological studies, provides a range of management options that can be tailored to individual needs. We suggest that non-pharmacological interventions (including psychosocial/psychological counseling, interpersonal management and environmental management) should be attempted first, followed by the least harmful medication for the shortest time possible. Pharmacological treatment options, such as antipsychotics, antidepressants, anticonvulsants, cholinesterase inhibitors and memantine, need careful consideration of the benefits and limitations of each drug class.</div>
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<server><NO>FRANCIS 10-0266370 INIST</NO>
<ET>Management of behavioral problems in Alzheimer's disease</ET>
<AU>GAUTHIER (Serge); CUMMINGS (Jeffrey); BALLARD (Clive); BRODATY (Henry); GROSSBERG (George); ROBERT (Philippe); LYKETSOS (Constantine)</AU>
<AF>Alzheimer's Disease and Related Disorders Unit at the McGill Centerfor Studies in Aging Douglas Mental Health University Institute/Montreal/Canada (1 aut.); Mary S. Easton Center for Alzheimer's Disease Research at UCLA/Los Angeles, California/Etats-Unis (2 aut.); Age Related Diseases, King's College London/London/Royaume-Uni (3 aut.); Primary Dementia Collaborative Research Centre, School of Psychiatry, University of New South Wales/Sydney/Australie (4 aut.); Department of Neurology and Psychiatry, St Louis University School of Medicine/St Louis, Missouri/Etats-Unis (5 aut.); Centre Mémoire de Ressources et de Recherche (Memory Centre for Care and Research), CHU de Nice, Hôpital Pasteur/Nice/France (6 aut.); Department of Psychiatry, The Johns Hopkins Bayview Medical Center/Baltimore, Maryland/Etats-Unis (7 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>International psychogeriatrics; ISSN 1041-6102; Etats-Unis; Da. 2010; Vol. 22; No. 3; Pp. 346-372; Bibl. 7 p.</SO>
<LA>Anglais</LA>
<EA>Alzheimer's disease (AD) is a complex progressive brain degenerative disorder that has effects on multiple cerebral systems. In addition to cognitive and functional decline, diverse behavioral changes manifest with increasing severity over time, presenting significant management challenges for caregivers and health care professionals. Almost all patients with AD are affected by neuropsychiatric symptoms at some point during their illness; in some cases, symptoms occur prior to diagnosis of the dementia syndrome. Further, behavioral factors have been identified, which may have their origins in particular neurobiological processes, and respond to particular management strategies. Improved clarification of causes, triggers, and presentation of neuropsychiatric symptoms will guide both research and clinical decision-making. Measurement of neuropsychiatric symptoms in AD is most commonly by means of the Neuropsychiatric Inventory; its utility and future development are discussed, as are the limitations and difficulties encountered when quantifying behavioral responses in clinical trials. Evidence from clinical trials of both non-pharmacological and pharmacological treatments, and from neurobiological studies, provides a range of management options that can be tailored to individual needs. We suggest that non-pharmacological interventions (including psychosocial/psychological counseling, interpersonal management and environmental management) should be attempted first, followed by the least harmful medication for the shortest time possible. Pharmacological treatment options, such as antipsychotics, antidepressants, anticonvulsants, cholinesterase inhibitors and memantine, need careful consideration of the benefits and limitations of each drug class.</EA>
<CC>770D05; 770D03M</CC>
<FD>Gestion; Trouble du comportement; Démence d'Alzheimer; Comportement; Traitement; Personne âgée</FD>
<FG>Homme; Pathologie de l'encéphale; Maladie dégénérative; Pathologie du système nerveux central; Pathologie du système nerveux</FG>
<ED>Management; Behavioral disorder; Alzheimer disease; Behavior; Treatment; Elderly</ED>
<EG>Human; Cerebral disorder; Degenerative disease; Central nervous system disease; Nervous system diseases</EG>
<SD>Gestión; Trastorno conducta; Demencia Alzheimer; Conducta; Tratamiento; Anciano</SD>
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<ID>10-0266370</ID>
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