Hybridisation-based resequencing of 17 X-linked intellectual disability genes in 135 patients reveals novel mutations in ATRX, SLC6A8 and PQBP1
Identifieur interne : 002209 ( PascalFrancis/Corpus ); précédent : 002208; suivant : 002210Hybridisation-based resequencing of 17 X-linked intellectual disability genes in 135 patients reveals novel mutations in ATRX, SLC6A8 and PQBP1
Auteurs : Lars R. Jensen ; WEI CHEN ; Bettina Moser ; Bettina Lipkowitz ; Christopher Schroeder ; Luciana Musante ; Andreas Tzschach ; Vera M. Kalscheuer ; Ilaria Meloni ; Martine Raynaud ; Hilde Van Esch ; Jamel Chelly ; Arjan Pm De Brouwer ; Anna Hackett ; Sigrun Van Der Haar ; Wolfram Henn ; Jozef Gecz ; Olaf Riess ; Michael Bonin ; Richard Reinhardt ; Hans-Hilger Ropers ; Andreas W. KussSource :
- European journal of human genetics [ 1018-4813 ] ; 2011.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
X-linked intellectual disability (XLID), also known as X-linked mental retardation, is a highly genetically heterogeneous condition for which mutations in >90 different genes have been identified. In this study, we used a custom-made sequencing array based on the Affymetrix 50k platform for mutation screening in 17 known XLID genes in patients from 135 families and found eight single-nucleotide changes that were absent in controls. For four mutations affecting ATRX (p.1761M>T), PQBP1 (p.155R>X) and SLC6A8 (p.390P>L and p.477S > L), we provide evidence for a functional involvement of these changes in the aetiology of intellectual disability.
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NO : | FRANCIS 11-0252313 INIST |
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ET : | Hybridisation-based resequencing of 17 X-linked intellectual disability genes in 135 patients reveals novel mutations in ATRX, SLC6A8 and PQBP1 |
AU : | JENSEN (Lars R.); WEI CHEN; MOSER (Bettina); LIPKOWITZ (Bettina); SCHROEDER (Christopher); MUSANTE (Luciana); TZSCHACH (Andreas); KALSCHEUER (Vera M.); MELONI (Ilaria); RAYNAUD (Martine); VAN ESCH (Hilde); CHELLY (Jamel); DE BROUWER (Arjan Pm); HACKETT (Anna); VAN DER HAAR (Sigrun); HENN (Wolfram); GECZ (Jozef); RIESS (Olaf); BONIN (Michael); REINHARDT (Richard); ROPERS (Hans-Hilger); KUSS (Andreas W.) |
AF : | Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics/Berlin/Allemagne (1 aut., 2 aut., 3 aut., 4 aut., 6 aut., 7 aut., 8 aut., 20 aut., 21 aut., 22 aut.); Department of Medical Genetics, University of Tubingen/Tubingen/Allemagne (5 aut., 18 aut., 19 aut.); Medical Genetics Unit, Department of Molecular Biology, University of Siena/Siena/Italie (9 aut.); Services de Genetique (INSERM)/Tours/France (10 aut.); Centre for Human Genetics, University Hospital Leuven/Leuven/Belgique (11 aut.); Institut Cochin de Génétique Moléculaire, Centre National de la Recherche Scientifique (INSERM)/Paris/France (12 aut.); Department of Human Genetics, Nijmegen Centre for Molecular Life Sciences and Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Center/Nijmegen/Pays-Bas (13 aut.); The GOLD Service, Hunter Genetics/Waratah, New South Wales/Australie (14 aut.); Practice for Gynaecology and Medical Genetics/Nuremberg/Allemagne (15 aut.); Institute of Human Genetics, University Hospital Homburg/Saarland/Homburg/Saar/Allemagne (16 aut.); Department of Genetics and Molecular Pathology, SA Pathology at the Women's and Children's Hospital, University of Adelaide/Adelaide/Australie (17 aut.); Department of Paediatrics, University of Adelaide/Adelaide/Australie (17 aut.) |
DT : | Publication en série; Courte communication, note brève; Niveau analytique |
SO : | European journal of human genetics; ISSN 1018-4813; Royaume-Uni; Da. 2011; Vol. 19; No. 6; Pp. 717-720; Bibl. 16 ref. |
LA : | Anglais |
EA : | X-linked intellectual disability (XLID), also known as X-linked mental retardation, is a highly genetically heterogeneous condition for which mutations in >90 different genes have been identified. In this study, we used a custom-made sequencing array based on the Affymetrix 50k platform for mutation screening in 17 known XLID genes in patients from 135 families and found eight single-nucleotide changes that were absent in controls. For four mutations affecting ATRX (p.1761M>T), PQBP1 (p.155R>X) and SLC6A8 (p.390P>L and p.477S > L), we provide evidence for a functional involvement of these changes in the aetiology of intellectual disability. |
CC : | 770D03L |
FD : | Arriération mentale; Déficience intellectuelle; Chromosome X anormal; Génétique; Gène; Homme; Malade; Mutation; Maladie héréditaire; Chromosome X; Caractère lié au sexe; Automatisation; Méthode; Réaction chaîne polymérase |
FG : | Chromosome anormal; Aberration chromosomique; Trouble du développement; Biologie moléculaire |
ED : | Mental retardation; Intellectual deficiency; Abnormal X chromosome; Genetics; Gene; Human; Patient; Mutation; Genetic disease; X-Chromosome; Sex linked character; Automation; Method; Polymerase chain reaction |
EG : | Abnormal chromosome; Chromosomal aberration; Developmental disorder; Molecular biology |
SD : | Retraso mental; Deficiencia intelectual; Cromosoma X anormal; Genética; Gen; Hombre; Enfermo; Mutación; Enfermedad hereditaria; Cromosoma X; Carácter ligado al sexo; Automatización; Método; Reacción cadena polimerasa |
LO : | INIST-27370.354000192109890160 |
ID : | 11-0252313 |
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Francis:11-0252313Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Hybridisation-based resequencing of 17 X-linked intellectual disability genes in 135 patients reveals novel mutations in ATRX, SLC6A8 and PQBP1</title>
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<affiliation><inist:fA14 i1="01"><s1>Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics</s1>
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<author><name sortKey="Wei Chen" sort="Wei Chen" uniqKey="Wei Chen" last="Wei Chen">WEI CHEN</name>
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<affiliation><inist:fA14 i1="01"><s1>Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics</s1>
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<affiliation><inist:fA14 i1="01"><s1>Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics</s1>
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<s3>ITA</s3>
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<affiliation><inist:fA14 i1="04"><s1>Services de Genetique (INSERM)</s1>
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<sZ>10 aut.</sZ>
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<affiliation><inist:fA14 i1="05"><s1>Centre for Human Genetics, University Hospital Leuven</s1>
<s2>Leuven</s2>
<s3>BEL</s3>
<sZ>11 aut.</sZ>
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<author><name sortKey="Chelly, Jamel" sort="Chelly, Jamel" uniqKey="Chelly J" first="Jamel" last="Chelly">Jamel Chelly</name>
<affiliation><inist:fA14 i1="06"><s1>Institut Cochin de Génétique Moléculaire, Centre National de la Recherche Scientifique (INSERM)</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>12 aut.</sZ>
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<author><name sortKey="De Brouwer, Arjan Pm" sort="De Brouwer, Arjan Pm" uniqKey="De Brouwer A" first="Arjan Pm" last="De Brouwer">Arjan Pm De Brouwer</name>
<affiliation><inist:fA14 i1="07"><s1>Department of Human Genetics, Nijmegen Centre for Molecular Life Sciences and Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Center</s1>
<s2>Nijmegen</s2>
<s3>NLD</s3>
<sZ>13 aut.</sZ>
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<author><name sortKey="Hackett, Anna" sort="Hackett, Anna" uniqKey="Hackett A" first="Anna" last="Hackett">Anna Hackett</name>
<affiliation><inist:fA14 i1="08"><s1>The GOLD Service, Hunter Genetics</s1>
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<s3>AUS</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
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<author><name sortKey="Van Der Haar, Sigrun" sort="Van Der Haar, Sigrun" uniqKey="Van Der Haar S" first="Sigrun" last="Van Der Haar">Sigrun Van Der Haar</name>
<affiliation><inist:fA14 i1="09"><s1>Practice for Gynaecology and Medical Genetics</s1>
<s2>Nuremberg</s2>
<s3>DEU</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
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<affiliation><inist:fA14 i1="10"><s1>Institute of Human Genetics, University Hospital Homburg/Saarland</s1>
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<s3>DEU</s3>
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<author><name sortKey="Gecz, Jozef" sort="Gecz, Jozef" uniqKey="Gecz J" first="Jozef" last="Gecz">Jozef Gecz</name>
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<s3>AUS</s3>
<sZ>17 aut.</sZ>
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<affiliation><inist:fA14 i1="12"><s1>Department of Paediatrics, University of Adelaide</s1>
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<sZ>17 aut.</sZ>
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<affiliation><inist:fA14 i1="02"><s1>Department of Medical Genetics, University of Tubingen</s1>
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<s3>DEU</s3>
<sZ>5 aut.</sZ>
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<affiliation><inist:fA14 i1="02"><s1>Department of Medical Genetics, University of Tubingen</s1>
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<s3>DEU</s3>
<sZ>5 aut.</sZ>
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<affiliation><inist:fA14 i1="01"><s1>Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics</s1>
<s2>Berlin</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
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<affiliation><inist:fA14 i1="01"><s1>Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics</s1>
<s2>Berlin</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
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<sZ>21 aut.</sZ>
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<author><name sortKey="Kuss, Andreas W" sort="Kuss, Andreas W" uniqKey="Kuss A" first="Andreas W." last="Kuss">Andreas W. Kuss</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics</s1>
<s2>Berlin</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
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<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
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<series><title level="j" type="main">European journal of human genetics</title>
<title level="j" type="abbreviated">Eur. j. hum. genet.</title>
<idno type="ISSN">1018-4813</idno>
<imprint><date when="2011">2011</date>
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<seriesStmt><title level="j" type="main">European journal of human genetics</title>
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<idno type="ISSN">1018-4813</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Abnormal X chromosome</term>
<term>Automation</term>
<term>Gene</term>
<term>Genetic disease</term>
<term>Genetics</term>
<term>Human</term>
<term>Intellectual deficiency</term>
<term>Mental retardation</term>
<term>Method</term>
<term>Mutation</term>
<term>Patient</term>
<term>Polymerase chain reaction</term>
<term>Sex linked character</term>
<term>X-Chromosome</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Arriération mentale</term>
<term>Déficience intellectuelle</term>
<term>Chromosome X anormal</term>
<term>Génétique</term>
<term>Gène</term>
<term>Homme</term>
<term>Malade</term>
<term>Mutation</term>
<term>Maladie héréditaire</term>
<term>Chromosome X</term>
<term>Caractère lié au sexe</term>
<term>Automatisation</term>
<term>Méthode</term>
<term>Réaction chaîne polymérase</term>
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<front><div type="abstract" xml:lang="en">X-linked intellectual disability (XLID), also known as X-linked mental retardation, is a highly genetically heterogeneous condition for which mutations in >90 different genes have been identified. In this study, we used a custom-made sequencing array based on the Affymetrix 50k platform for mutation screening in 17 known XLID genes in patients from 135 families and found eight single-nucleotide changes that were absent in controls. For four mutations affecting ATRX (p.1761M>T), PQBP1 (p.155R>X) and SLC6A8 (p.390P>L and p.477S > L), we provide evidence for a functional involvement of these changes in the aetiology of intellectual disability.</div>
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<fA08 i1="01" i2="1" l="ENG"><s1>Hybridisation-based resequencing of 17 X-linked intellectual disability genes in 135 patients reveals novel mutations in ATRX, SLC6A8 and PQBP1</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>JENSEN (Lars R.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>WEI CHEN</s1>
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<fA11 i1="03" i2="1"><s1>MOSER (Bettina)</s1>
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<fA11 i1="04" i2="1"><s1>LIPKOWITZ (Bettina)</s1>
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<fA11 i1="05" i2="1"><s1>SCHROEDER (Christopher)</s1>
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<fA11 i1="09" i2="1"><s1>MELONI (Ilaria)</s1>
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<fA11 i1="15" i2="1"><s1>VAN DER HAAR (Sigrun)</s1>
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<fA11 i1="16" i2="1"><s1>HENN (Wolfram)</s1>
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<fA11 i1="17" i2="1"><s1>GECZ (Jozef)</s1>
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<fA11 i1="18" i2="1"><s1>RIESS (Olaf)</s1>
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<fA11 i1="19" i2="1"><s1>BONIN (Michael)</s1>
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<fA11 i1="20" i2="1"><s1>REINHARDT (Richard)</s1>
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<fA11 i1="21" i2="1"><s1>ROPERS (Hans-Hilger)</s1>
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<fA11 i1="22" i2="1"><s1>KUSS (Andreas W.)</s1>
</fA11>
<fA14 i1="01"><s1>Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics</s1>
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<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
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<sZ>20 aut.</sZ>
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<fA14 i1="02"><s1>Department of Medical Genetics, University of Tubingen</s1>
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<sZ>19 aut.</sZ>
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<fA14 i1="03"><s1>Medical Genetics Unit, Department of Molecular Biology, University of Siena</s1>
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<fA14 i1="04"><s1>Services de Genetique (INSERM)</s1>
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<fA14 i1="06"><s1>Institut Cochin de Génétique Moléculaire, Centre National de la Recherche Scientifique (INSERM)</s1>
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<s3>FRA</s3>
<sZ>12 aut.</sZ>
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<fA14 i1="07"><s1>Department of Human Genetics, Nijmegen Centre for Molecular Life Sciences and Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Center</s1>
<s2>Nijmegen</s2>
<s3>NLD</s3>
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<fA14 i1="08"><s1>The GOLD Service, Hunter Genetics</s1>
<s2>Waratah, New South Wales</s2>
<s3>AUS</s3>
<sZ>14 aut.</sZ>
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<fA14 i1="09"><s1>Practice for Gynaecology and Medical Genetics</s1>
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<s3>DEU</s3>
<sZ>15 aut.</sZ>
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<fA14 i1="10"><s1>Institute of Human Genetics, University Hospital Homburg/Saarland</s1>
<s2>Homburg/Saar</s2>
<s3>DEU</s3>
<sZ>16 aut.</sZ>
</fA14>
<fA14 i1="11"><s1>Department of Genetics and Molecular Pathology, SA Pathology at the Women's and Children's Hospital, University of Adelaide</s1>
<s2>Adelaide</s2>
<s3>AUS</s3>
<sZ>17 aut.</sZ>
</fA14>
<fA14 i1="12"><s1>Department of Paediatrics, University of Adelaide</s1>
<s2>Adelaide</s2>
<s3>AUS</s3>
<sZ>17 aut.</sZ>
</fA14>
<fA20><s1>717-720</s1>
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<fA21><s1>2011</s1>
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<fA23 i1="01"><s0>ENG</s0>
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<fA47 i1="01" i2="1"><s0>11-0252313</s0>
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<fA60><s1>P</s1>
<s3>CC</s3>
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<fA61><s0>A</s0>
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<fA64 i1="01" i2="1"><s0>European journal of human genetics</s0>
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<fA66 i1="01"><s0>GBR</s0>
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<fC01 i1="01" l="ENG"><s0>X-linked intellectual disability (XLID), also known as X-linked mental retardation, is a highly genetically heterogeneous condition for which mutations in >90 different genes have been identified. In this study, we used a custom-made sequencing array based on the Affymetrix 50k platform for mutation screening in 17 known XLID genes in patients from 135 families and found eight single-nucleotide changes that were absent in controls. For four mutations affecting ATRX (p.1761M>T), PQBP1 (p.155R>X) and SLC6A8 (p.390P>L and p.477S > L), we provide evidence for a functional involvement of these changes in the aetiology of intellectual disability.</s0>
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<fC02 i1="01" i2="X"><s0>770D03L</s0>
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<fC03 i1="11" i2="X" l="FRE"><s0>Caractère lié au sexe</s0>
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<s5>18</s5>
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<fC03 i1="13" i2="X" l="SPA"><s0>Método</s0>
<s5>18</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>Réaction chaîne polymérase</s0>
<s5>19</s5>
</fC03>
<fC03 i1="14" i2="X" l="ENG"><s0>Polymerase chain reaction</s0>
<s5>19</s5>
</fC03>
<fC03 i1="14" i2="X" l="SPA"><s0>Reacción cadena polimerasa</s0>
<s5>19</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Chromosome anormal</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Abnormal chromosome</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Cromosoma anormal</s0>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Aberration chromosomique</s0>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Chromosomal aberration</s0>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Aberración cromosómica</s0>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Trouble du développement</s0>
<s5>37</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Developmental disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Trastorno desarrollo</s0>
<s5>37</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Biologie moléculaire</s0>
<s5>38</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Molecular biology</s0>
<s5>38</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Biología molecular</s0>
<s5>38</s5>
</fC07>
<fN21><s1>171</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>FRANCIS 11-0252313 INIST</NO>
<ET>Hybridisation-based resequencing of 17 X-linked intellectual disability genes in 135 patients reveals novel mutations in ATRX, SLC6A8 and PQBP1</ET>
<AU>JENSEN (Lars R.); WEI CHEN; MOSER (Bettina); LIPKOWITZ (Bettina); SCHROEDER (Christopher); MUSANTE (Luciana); TZSCHACH (Andreas); KALSCHEUER (Vera M.); MELONI (Ilaria); RAYNAUD (Martine); VAN ESCH (Hilde); CHELLY (Jamel); DE BROUWER (Arjan Pm); HACKETT (Anna); VAN DER HAAR (Sigrun); HENN (Wolfram); GECZ (Jozef); RIESS (Olaf); BONIN (Michael); REINHARDT (Richard); ROPERS (Hans-Hilger); KUSS (Andreas W.)</AU>
<AF>Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics/Berlin/Allemagne (1 aut., 2 aut., 3 aut., 4 aut., 6 aut., 7 aut., 8 aut., 20 aut., 21 aut., 22 aut.); Department of Medical Genetics, University of Tubingen/Tubingen/Allemagne (5 aut., 18 aut., 19 aut.); Medical Genetics Unit, Department of Molecular Biology, University of Siena/Siena/Italie (9 aut.); Services de Genetique (INSERM)/Tours/France (10 aut.); Centre for Human Genetics, University Hospital Leuven/Leuven/Belgique (11 aut.); Institut Cochin de Génétique Moléculaire, Centre National de la Recherche Scientifique (INSERM)/Paris/France (12 aut.); Department of Human Genetics, Nijmegen Centre for Molecular Life Sciences and Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Center/Nijmegen/Pays-Bas (13 aut.); The GOLD Service, Hunter Genetics/Waratah, New South Wales/Australie (14 aut.); Practice for Gynaecology and Medical Genetics/Nuremberg/Allemagne (15 aut.); Institute of Human Genetics, University Hospital Homburg/Saarland/Homburg/Saar/Allemagne (16 aut.); Department of Genetics and Molecular Pathology, SA Pathology at the Women's and Children's Hospital, University of Adelaide/Adelaide/Australie (17 aut.); Department of Paediatrics, University of Adelaide/Adelaide/Australie (17 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>European journal of human genetics; ISSN 1018-4813; Royaume-Uni; Da. 2011; Vol. 19; No. 6; Pp. 717-720; Bibl. 16 ref.</SO>
<LA>Anglais</LA>
<EA>X-linked intellectual disability (XLID), also known as X-linked mental retardation, is a highly genetically heterogeneous condition for which mutations in >90 different genes have been identified. In this study, we used a custom-made sequencing array based on the Affymetrix 50k platform for mutation screening in 17 known XLID genes in patients from 135 families and found eight single-nucleotide changes that were absent in controls. For four mutations affecting ATRX (p.1761M>T), PQBP1 (p.155R>X) and SLC6A8 (p.390P>L and p.477S > L), we provide evidence for a functional involvement of these changes in the aetiology of intellectual disability.</EA>
<CC>770D03L</CC>
<FD>Arriération mentale; Déficience intellectuelle; Chromosome X anormal; Génétique; Gène; Homme; Malade; Mutation; Maladie héréditaire; Chromosome X; Caractère lié au sexe; Automatisation; Méthode; Réaction chaîne polymérase</FD>
<FG>Chromosome anormal; Aberration chromosomique; Trouble du développement; Biologie moléculaire</FG>
<ED>Mental retardation; Intellectual deficiency; Abnormal X chromosome; Genetics; Gene; Human; Patient; Mutation; Genetic disease; X-Chromosome; Sex linked character; Automation; Method; Polymerase chain reaction</ED>
<EG>Abnormal chromosome; Chromosomal aberration; Developmental disorder; Molecular biology</EG>
<SD>Retraso mental; Deficiencia intelectual; Cromosoma X anormal; Genética; Gen; Hombre; Enfermo; Mutación; Enfermedad hereditaria; Cromosoma X; Carácter ligado al sexo; Automatización; Método; Reacción cadena polimerasa</SD>
<LO>INIST-27370.354000192109890160</LO>
<ID>11-0252313</ID>
</server>
</inist>
</record>
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