Genome-wide association study confirms BST1 and suggests a locus on 12q24 as the risk loci for Parkinson's disease in the European population
Identifieur interne : 001F21 ( PascalFrancis/Corpus ); précédent : 001F20; suivant : 001F22Genome-wide association study confirms BST1 and suggests a locus on 12q24 as the risk loci for Parkinson's disease in the European population
Auteurs : Mohamad Saad ; Suzanne Lesage ; Aude Saint-Pierre ; Jean-Christophe Corvol ; Diana Zelenika ; Jean-Charles Lambert ; Marie Vidailhet ; George D. Mellick ; Ebba Lohmann ; Franck Durif ; Pierre Pollak ; Philippe Damier ; François Tison ; Peter A. Silburn ; Christophe Tzourio ; Sylvie Foriani ; Marie-Anne Loriot ; Maurice Giroud ; Catherine Helmer ; Florence Portet ; Philippe Amouyel ; Mark Lathrop ; Alexis Elbaz ; Alexandra Durr ; Maria Martinez ; Alexis BriceSource :
- Human molecular genetics : (Print) [ 0964-6906 ] ; 2011.
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Abstract
We performed a three-stage genome-wide association study (GWAS) to identify common Parkinson's disease (PD) risk variants in the European population. The initial genome-wide scan was conducted in a French sample of 1039 cases and 1984 controls, using almost 500 000 single nucleotide polymorphisms (SNPs). Two SNPs at SNCA were found to be associated with PD at the genome-wide significance level (P < 3 × 10-8). An additional set of promising and new association signals was identified and submitted for immediate replication in two independent case-control studies of subjects of European descent. We first carried out an in silico replication study using GWAS data from the WTCCC2 PD study sample (1705 cases, 5200 WTCCC controls). Nominally replicated SNPs were further genotyped in a third sample of 1527 cases and 1864 controls from France and Australia. We found converging evidence of association with PD on 12q24 (rs4964469, combined P = 2.4 × 10-7) and confirmed the association on 4p15/BST1 (rs4698412, combined P = 1.8 x 10-6), previously reported in Japanese data. The 12q24 locus includes RFX4, an isoform of which, named RFX4_v3, encodes brain-specific transcription factors that regulate many genes involved in brain morphogenesis and intracellular calcium homeostasis.
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| NO : | PASCAL 11-0154525 INIST |
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| ET : | Genome-wide association study confirms BST1 and suggests a locus on 12q24 as the risk loci for Parkinson's disease in the European population |
| AU : | SAAD (Mohamad); LESAGE (Suzanne); SAINT-PIERRE (Aude); CORVOL (Jean-Christophe); ZELENIKA (Diana); LAMBERT (Jean-Charles); VIDAILHET (Marie); MELLICK (George D.); LOHMANN (Ebba); DURIF (Franck); POLLAK (Pierre); DAMIER (Philippe); TISON (François); SILBURN (Peter A.); TZOURIO (Christophe); FORIANI (Sylvie); LORIOT (Marie-Anne); GIROUD (Maurice); HELMER (Catherine); PORTET (Florence); AMOUYEL (Philippe); LATHROP (Mark); ELBAZ (Alexis); DURR (Alexandra); MARTINEZ (Maria); BRICE (Alexis) |
| AF : | INSERM U563, CPTP, CHU Purpan/31024 Toulouse/France (1 aut., 3 aut., 25 aut.); Paul Sabatier University/Toulouse/France (1 aut., 3 aut., 25 aut.); Université Pierre et Marie Curie-Paris6, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UMR-S975/Paris/France (2 aut., 4 aut., 7 aut., 9 aut., 16 aut., 24 aut., 26 aut.); INSERM U975/Paris/France (2 aut., 4 aut., 7 aut., 9 aut., 16 aut., 24 aut., 26 aut.); CNRS, UMR 7225/Paris/France (2 aut., 4 aut., 7 aut., 9 aut., 16 aut., 24 aut., 26 aut.); INSERM CIC-9503, Hôpital Pitié-Salpêtrière/Paris/France (4 aut.); Centre National de Génotypage, Institut Génomique, Commissariat à l'Energie Atomique/Evry/France (5 aut., 22 aut.); INSERM U744/Lille/France (6 aut., 21 aut.); Institut Pasteur de Lille/Lille/France (6 aut., 21 aut.); Université de Lille Nord/Lille/France (6 aut., 21 aut.); National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University/Brisbane, Queensland/Australie (8 aut., 14 aut.); Department of Neurology, Princess Alexandra Hospital/Brisbane, Queensland/Australie (8 aut., 14 aut.); Service de Neurologie, Hôpital Gabriel Montpied/Clermont-Ferrand/France (10 aut.); Service de Neurologie, CHU de Grenoble/Grenoble/France (11 aut.); CHU Nantes, CIC0004, Service de Neurologie/Nantes/France (12 aut.); Service de Neurologie, Hôpital Haut-Lévêque/Pessac/France (13 aut.); INSERM U708/Paris/France (15 aut., 23 aut.); Université Pierre et Marie Curie Paris6/Paris/France (15 aut., 23 aut.); UMR-S775/Paris/France (17 aut.); Université Paris Descartes/Paris/France (17 aut.); AP-HP, Hôpital Européen Georges Pompidou/Paris/France (17 aut.); Centre Hospitalier Dijon/Dijon/France (18 aut.); INSERM, CR897, Université Victor Segalen Bordeaux-2/Bordeaux/France (19 aut.); INSERM U888/Montpellier/France (20 aut.); CHRU de Lille/Lille/France (21 aut.) |
| DT : | Publication en série; Niveau analytique |
| SO : | Human molecular genetics : (Print); ISSN 0964-6906; Royaume-Uni; Da. 2011; Vol. 20; No. 3; Pp. 615-627; Bibl. 23 ref. |
| LA : | Anglais |
| EA : | We performed a three-stage genome-wide association study (GWAS) to identify common Parkinson's disease (PD) risk variants in the European population. The initial genome-wide scan was conducted in a French sample of 1039 cases and 1984 controls, using almost 500 000 single nucleotide polymorphisms (SNPs). Two SNPs at SNCA were found to be associated with PD at the genome-wide significance level (P < 3 × 10-8). An additional set of promising and new association signals was identified and submitted for immediate replication in two independent case-control studies of subjects of European descent. We first carried out an in silico replication study using GWAS data from the WTCCC2 PD study sample (1705 cases, 5200 WTCCC controls). Nominally replicated SNPs were further genotyped in a third sample of 1527 cases and 1864 controls from France and Australia. We found converging evidence of association with PD on 12q24 (rs4964469, combined P = 2.4 × 10-7) and confirmed the association on 4p15/BST1 (rs4698412, combined P = 1.8 x 10-6), previously reported in Japanese data. The 12q24 locus includes RFX4, an isoform of which, named RFX4_v3, encodes brain-specific transcription factors that regulate many genes involved in brain morphogenesis and intracellular calcium homeostasis. |
| CC : | 002A04; 002A07; 002B17G |
| FD : | Association; Locus; Chromosome C12; Risque; Facteur risque; Européen; Europe; Homme; Génétique; Maladie de Parkinson; Echelle du génome |
| FG : | Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central; Pathologie du système nerveux |
| ED : | Association; Locus; Chromosome C12; Risk; Risk factor; European; Europe; Human; Genetics; Parkinson disease |
| EG : | Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Nervous system diseases |
| SD : | Asociación; Locus; Cromosoma C12; Riesgo; Factor riesgo; Europeo; Europa; Hombre; Genética; Parkinson enfermedad |
| LO : | INIST-22540.354000191994630180 |
| ID : | 11-0154525 |
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Pascal:11-0154525Le document en format XML
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Silburn</name><affiliation><inist:fA14 i1="11"><s1>National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>8 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="12"><s1>Department of Neurology, Princess Alexandra Hospital</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>8 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation><inist:fA14 i1="17"><s1>INSERM U708</s1><s2>Paris</s2><s3>FRA</s3><sZ>15 aut.</sZ><sZ>23 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="18"><s1>Université Pierre et Marie Curie Paris6</s1><s2>Paris</s2><s3>FRA</s3><sZ>15 aut.</sZ><sZ>23 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Foriani, Sylvie" sort="Foriani, Sylvie" uniqKey="Foriani S" first="Sylvie" last="Foriani">Sylvie Foriani</name><affiliation><inist:fA14 i1="03"><s1>Université Pierre et Marie Curie-Paris6, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UMR-S975</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ><sZ>24 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="04"><s1>INSERM U975</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ><sZ>24 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="05"><s1>CNRS, UMR 7225</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ><sZ>24 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Loriot, Marie Anne" sort="Loriot, Marie Anne" uniqKey="Loriot M" first="Marie-Anne" last="Loriot">Marie-Anne Loriot</name><affiliation><inist:fA14 i1="19"><s1>UMR-S775</s1><s2>Paris</s2><s3>FRA</s3><sZ>17 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="20"><s1>Université Paris Descartes</s1><s2>Paris</s2><s3>FRA</s3><sZ>17 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="21"><s1>AP-HP, Hôpital Européen Georges Pompidou</s1><s2>Paris</s2><s3>FRA</s3><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Giroud, Maurice" sort="Giroud, Maurice" uniqKey="Giroud M" first="Maurice" last="Giroud">Maurice Giroud</name><affiliation><inist:fA14 i1="22"><s1>Centre Hospitalier Dijon</s1><s2>Dijon</s2><s3>FRA</s3><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Helmer, Catherine" sort="Helmer, Catherine" uniqKey="Helmer C" first="Catherine" last="Helmer">Catherine Helmer</name><affiliation><inist:fA14 i1="23"><s1>INSERM, CR897, Université Victor Segalen Bordeaux-2</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>19 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Portet, Florence" sort="Portet, Florence" uniqKey="Portet F" first="Florence" last="Portet">Florence Portet</name><affiliation><inist:fA14 i1="24"><s1>INSERM U888</s1><s2>Montpellier</s2><s3>FRA</s3><sZ>20 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation><inist:fA14 i1="08"><s1>INSERM U744</s1><s2>Lille</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="09"><s1>Institut Pasteur de Lille</s1><s2>Lille</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="10"><s1>Université de Lille Nord</s1><s2>Lille</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="25"><s1>CHRU de Lille</s1><s2>Lille</s2><s3>FRA</s3><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><affiliation><inist:fA14 i1="07"><s1>Centre National de Génotypage, Institut Génomique, Commissariat à l'Energie Atomique</s1><s2>Evry</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>22 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation><inist:fA14 i1="17"><s1>INSERM U708</s1><s2>Paris</s2><s3>FRA</s3><sZ>15 aut.</sZ><sZ>23 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="18"><s1>Université Pierre et Marie Curie Paris6</s1><s2>Paris</s2><s3>FRA</s3><sZ>15 aut.</sZ><sZ>23 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Durr">Alexandra Durr</name><affiliation><inist:fA14 i1="03"><s1>Université Pierre et Marie Curie-Paris6, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UMR-S975</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ><sZ>24 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="04"><s1>INSERM U975</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ><sZ>24 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="05"><s1>CNRS, UMR 7225</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ><sZ>24 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Martinez, Maria" sort="Martinez, Maria" uniqKey="Martinez M" first="Maria" last="Martinez">Maria Martinez</name><affiliation><inist:fA14 i1="01"><s1>INSERM U563, CPTP, CHU Purpan</s1><s2>31024 Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>25 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>Paul Sabatier University</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>25 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation><inist:fA14 i1="03"><s1>Université Pierre et Marie Curie-Paris6, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UMR-S975</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ><sZ>24 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="04"><s1>INSERM U975</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ><sZ>24 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="05"><s1>CNRS, UMR 7225</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ><sZ>24 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">11-0154525</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 11-0154525 INIST</idno><idno type="RBID">Pascal:11-0154525</idno><idno type="wicri:Area/PascalFrancis/Corpus">001F21</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Genome-wide association study confirms BST1 and suggests a locus on 12q24 as the risk loci for Parkinson's disease in the European population</title><author><name sortKey="Saad, Mohamad" sort="Saad, Mohamad" uniqKey="Saad M" first="Mohamad" last="Saad">Mohamad Saad</name><affiliation><inist:fA14 i1="01"><s1>INSERM U563, CPTP, CHU Purpan</s1><s2>31024 Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>25 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>Paul Sabatier University</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>25 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name><affiliation><inist:fA14 i1="03"><s1>Université Pierre et Marie Curie-Paris6, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UMR-S975</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ><sZ>24 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="04"><s1>INSERM U975</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ><sZ>24 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="05"><s1>CNRS, UMR 7225</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ><sZ>24 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Saint Pierre, Aude" sort="Saint Pierre, Aude" uniqKey="Saint Pierre A" first="Aude" last="Saint-Pierre">Aude Saint-Pierre</name><affiliation><inist:fA14 i1="01"><s1>INSERM U563, CPTP, CHU Purpan</s1><s2>31024 Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>25 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>Paul Sabatier University</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>25 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Corvol, Jean Christophe" sort="Corvol, Jean Christophe" uniqKey="Corvol J" first="Jean-Christophe" last="Corvol">Jean-Christophe Corvol</name><affiliation><inist:fA14 i1="03"><s1>Université Pierre et Marie Curie-Paris6, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UMR-S975</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ><sZ>24 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="04"><s1>INSERM U975</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ><sZ>24 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="05"><s1>CNRS, UMR 7225</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ><sZ>24 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="06"><s1>INSERM CIC-9503, Hôpital Pitié-Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>4 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Zelenika, Diana" sort="Zelenika, Diana" uniqKey="Zelenika D" first="Diana" last="Zelenika">Diana Zelenika</name><affiliation><inist:fA14 i1="07"><s1>Centre National de Génotypage, Institut Génomique, Commissariat à l'Energie Atomique</s1><s2>Evry</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>22 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation><inist:fA14 i1="08"><s1>INSERM U744</s1><s2>Lille</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="09"><s1>Institut Pasteur de Lille</s1><s2>Lille</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="10"><s1>Université de Lille Nord</s1><s2>Lille</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name><affiliation><inist:fA14 i1="03"><s1>Université Pierre et Marie Curie-Paris6, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UMR-S975</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ><sZ>24 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="04"><s1>INSERM U975</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ><sZ>24 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="05"><s1>CNRS, UMR 7225</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ><sZ>24 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name><affiliation><inist:fA14 i1="11"><s1>National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>8 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="12"><s1>Department of Neurology, Princess Alexandra Hospital</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>8 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Lohmann, Ebba" sort="Lohmann, Ebba" uniqKey="Lohmann E" first="Ebba" last="Lohmann">Ebba Lohmann</name><affiliation><inist:fA14 i1="03"><s1>Université Pierre et Marie Curie-Paris6, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UMR-S975</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ><sZ>24 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="04"><s1>INSERM U975</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ><sZ>24 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="05"><s1>CNRS, UMR 7225</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ><sZ>24 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Durif, Franck" sort="Durif, Franck" uniqKey="Durif F" first="Franck" last="Durif">Franck Durif</name><affiliation><inist:fA14 i1="13"><s1>Service de Neurologie, Hôpital Gabriel Montpied</s1><s2>Clermont-Ferrand</s2><s3>FRA</s3><sZ>10 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><affiliation><inist:fA14 i1="14"><s1>Service de Neurologie, CHU de Grenoble</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>11 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Damier, Philippe" sort="Damier, Philippe" uniqKey="Damier P" first="Philippe" last="Damier">Philippe Damier</name><affiliation><inist:fA14 i1="15"><s1>CHU Nantes, CIC0004, Service de Neurologie</s1><s2>Nantes</s2><s3>FRA</s3><sZ>12 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="François" last="Tison">François Tison</name><affiliation><inist:fA14 i1="16"><s1>Service de Neurologie, Hôpital Haut-Lévêque</s1><s2>Pessac</s2><s3>FRA</s3><sZ>13 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name><affiliation><inist:fA14 i1="11"><s1>National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>8 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="12"><s1>Department of Neurology, Princess Alexandra Hospital</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>8 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation><inist:fA14 i1="17"><s1>INSERM U708</s1><s2>Paris</s2><s3>FRA</s3><sZ>15 aut.</sZ><sZ>23 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="18"><s1>Université Pierre et Marie Curie Paris6</s1><s2>Paris</s2><s3>FRA</s3><sZ>15 aut.</sZ><sZ>23 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Foriani, Sylvie" sort="Foriani, Sylvie" uniqKey="Foriani S" first="Sylvie" last="Foriani">Sylvie Foriani</name><affiliation><inist:fA14 i1="03"><s1>Université Pierre et Marie Curie-Paris6, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UMR-S975</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ><sZ>24 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="04"><s1>INSERM U975</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ><sZ>24 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="05"><s1>CNRS, UMR 7225</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ><sZ>24 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Loriot, Marie Anne" sort="Loriot, Marie Anne" uniqKey="Loriot M" first="Marie-Anne" last="Loriot">Marie-Anne Loriot</name><affiliation><inist:fA14 i1="19"><s1>UMR-S775</s1><s2>Paris</s2><s3>FRA</s3><sZ>17 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="20"><s1>Université Paris Descartes</s1><s2>Paris</s2><s3>FRA</s3><sZ>17 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="21"><s1>AP-HP, Hôpital Européen Georges Pompidou</s1><s2>Paris</s2><s3>FRA</s3><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Giroud, Maurice" sort="Giroud, Maurice" uniqKey="Giroud M" first="Maurice" last="Giroud">Maurice Giroud</name><affiliation><inist:fA14 i1="22"><s1>Centre Hospitalier Dijon</s1><s2>Dijon</s2><s3>FRA</s3><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Helmer, Catherine" sort="Helmer, Catherine" uniqKey="Helmer C" first="Catherine" last="Helmer">Catherine Helmer</name><affiliation><inist:fA14 i1="23"><s1>INSERM, CR897, Université Victor Segalen Bordeaux-2</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>19 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Portet, Florence" sort="Portet, Florence" uniqKey="Portet F" first="Florence" last="Portet">Florence Portet</name><affiliation><inist:fA14 i1="24"><s1>INSERM U888</s1><s2>Montpellier</s2><s3>FRA</s3><sZ>20 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation><inist:fA14 i1="08"><s1>INSERM U744</s1><s2>Lille</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="09"><s1>Institut Pasteur de Lille</s1><s2>Lille</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="10"><s1>Université de Lille Nord</s1><s2>Lille</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="25"><s1>CHRU de Lille</s1><s2>Lille</s2><s3>FRA</s3><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><affiliation><inist:fA14 i1="07"><s1>Centre National de Génotypage, Institut Génomique, Commissariat à l'Energie Atomique</s1><s2>Evry</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>22 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation><inist:fA14 i1="17"><s1>INSERM U708</s1><s2>Paris</s2><s3>FRA</s3><sZ>15 aut.</sZ><sZ>23 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="18"><s1>Université Pierre et Marie Curie Paris6</s1><s2>Paris</s2><s3>FRA</s3><sZ>15 aut.</sZ><sZ>23 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Durr">Alexandra Durr</name><affiliation><inist:fA14 i1="03"><s1>Université Pierre et Marie Curie-Paris6, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UMR-S975</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ><sZ>24 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="04"><s1>INSERM U975</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ><sZ>24 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="05"><s1>CNRS, UMR 7225</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ><sZ>24 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Martinez, Maria" sort="Martinez, Maria" uniqKey="Martinez M" first="Maria" last="Martinez">Maria Martinez</name><affiliation><inist:fA14 i1="01"><s1>INSERM U563, CPTP, CHU Purpan</s1><s2>31024 Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>25 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>Paul Sabatier University</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>25 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation><inist:fA14 i1="03"><s1>Université Pierre et Marie Curie-Paris6, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UMR-S975</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ><sZ>24 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="04"><s1>INSERM U975</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ><sZ>24 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="05"><s1>CNRS, UMR 7225</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ><sZ>24 aut.</sZ><sZ>26 aut.</sZ></inist:fA14></affiliation></author></analytic><series><title level="j" type="main">Human molecular genetics : (Print)</title><title level="j" type="abbreviated">Hum. mol. genet. : (Print)</title><idno type="ISSN">0964-6906</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Human molecular genetics : (Print)</title><title level="j" type="abbreviated">Hum. mol. genet. : (Print)</title><idno type="ISSN">0964-6906</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Association</term><term>Chromosome C12</term><term>Europe</term><term>European</term><term>Genetics</term><term>Human</term><term>Locus</term><term>Parkinson disease</term><term>Risk</term><term>Risk factor</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Association</term><term>Locus</term><term>Chromosome C12</term><term>Risque</term><term>Facteur risque</term><term>Européen</term><term>Europe</term><term>Homme</term><term>Génétique</term><term>Maladie de Parkinson</term><term>Echelle du génome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We performed a three-stage genome-wide association study (GWAS) to identify common Parkinson's disease (PD) risk variants in the European population. The initial genome-wide scan was conducted in a French sample of 1039 cases and 1984 controls, using almost 500 000 single nucleotide polymorphisms (SNPs). Two SNPs at SNCA were found to be associated with PD at the genome-wide significance level (P < 3 × 10-<sup>8</sup>). An additional set of promising and new association signals was identified and submitted for immediate replication in two independent case-control studies of subjects of European descent. We first carried out an in silico replication study using GWAS data from the WTCCC2 PD study sample (1705 cases, 5200 WTCCC controls). Nominally replicated SNPs were further genotyped in a third sample of 1527 cases and 1864 controls from France and Australia. We found converging evidence of association with PD on 12q24 (rs4964469, combined P = 2.4 × 10<sup>-7</sup>) and confirmed the association on 4p15/BST1 (rs4698412, combined P = 1.8 x 10<sup>-6</sup>), previously reported in Japanese data. The 12q24 locus includes RFX4, an isoform of which, named RFX4_v3, encodes brain-specific transcription factors that regulate many genes involved in brain morphogenesis and intracellular calcium homeostasis.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0964-6906</s0></fA01><fA03 i2="1"><s0>Hum. mol. genet. : (Print)</s0></fA03><fA05><s2>20</s2></fA05><fA06><s2>3</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Genome-wide association study confirms BST1 and suggests a locus on 12q24 as the risk loci for Parkinson's disease in the European population</s1></fA08><fA11 i1="01" i2="1"><s1>SAAD (Mohamad)</s1></fA11><fA11 i1="02" i2="1"><s1>LESAGE (Suzanne)</s1></fA11><fA11 i1="03" i2="1"><s1>SAINT-PIERRE (Aude)</s1></fA11><fA11 i1="04" i2="1"><s1>CORVOL (Jean-Christophe)</s1></fA11><fA11 i1="05" i2="1"><s1>ZELENIKA (Diana)</s1></fA11><fA11 i1="06" i2="1"><s1>LAMBERT (Jean-Charles)</s1></fA11><fA11 i1="07" i2="1"><s1>VIDAILHET (Marie)</s1></fA11><fA11 i1="08" i2="1"><s1>MELLICK (George D.)</s1></fA11><fA11 i1="09" i2="1"><s1>LOHMANN (Ebba)</s1></fA11><fA11 i1="10" i2="1"><s1>DURIF (Franck)</s1></fA11><fA11 i1="11" i2="1"><s1>POLLAK (Pierre)</s1></fA11><fA11 i1="12" i2="1"><s1>DAMIER (Philippe)</s1></fA11><fA11 i1="13" i2="1"><s1>TISON (François)</s1></fA11><fA11 i1="14" i2="1"><s1>SILBURN (Peter A.)</s1></fA11><fA11 i1="15" i2="1"><s1>TZOURIO (Christophe)</s1></fA11><fA11 i1="16" i2="1"><s1>FORIANI (Sylvie)</s1></fA11><fA11 i1="17" i2="1"><s1>LORIOT (Marie-Anne)</s1></fA11><fA11 i1="18" i2="1"><s1>GIROUD (Maurice)</s1></fA11><fA11 i1="19" i2="1"><s1>HELMER (Catherine)</s1></fA11><fA11 i1="20" i2="1"><s1>PORTET (Florence)</s1></fA11><fA11 i1="21" i2="1"><s1>AMOUYEL (Philippe)</s1></fA11><fA11 i1="22" i2="1"><s1>LATHROP (Mark)</s1></fA11><fA11 i1="23" i2="1"><s1>ELBAZ (Alexis)</s1></fA11><fA11 i1="24" i2="1"><s1>DURR (Alexandra)</s1></fA11><fA11 i1="25" i2="1"><s1>MARTINEZ (Maria)</s1></fA11><fA11 i1="26" i2="1"><s1>BRICE (Alexis)</s1></fA11><fA14 i1="01"><s1>INSERM U563, CPTP, CHU Purpan</s1><s2>31024 Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>25 aut.</sZ></fA14><fA14 i1="02"><s1>Paul Sabatier University</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>25 aut.</sZ></fA14><fA14 i1="03"><s1>Université Pierre et Marie Curie-Paris6, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UMR-S975</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ><sZ>24 aut.</sZ><sZ>26 aut.</sZ></fA14><fA14 i1="04"><s1>INSERM U975</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ><sZ>24 aut.</sZ><sZ>26 aut.</sZ></fA14><fA14 i1="05"><s1>CNRS, UMR 7225</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ><sZ>24 aut.</sZ><sZ>26 aut.</sZ></fA14><fA14 i1="06"><s1>INSERM CIC-9503, Hôpital Pitié-Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>4 aut.</sZ></fA14><fA14 i1="07"><s1>Centre National de Génotypage, Institut Génomique, Commissariat à l'Energie Atomique</s1><s2>Evry</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>22 aut.</sZ></fA14><fA14 i1="08"><s1>INSERM U744</s1><s2>Lille</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>21 aut.</sZ></fA14><fA14 i1="09"><s1>Institut Pasteur de Lille</s1><s2>Lille</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>21 aut.</sZ></fA14><fA14 i1="10"><s1>Université de Lille Nord</s1><s2>Lille</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>21 aut.</sZ></fA14><fA14 i1="11"><s1>National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>8 aut.</sZ><sZ>14 aut.</sZ></fA14><fA14 i1="12"><s1>Department of Neurology, Princess Alexandra Hospital</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>8 aut.</sZ><sZ>14 aut.</sZ></fA14><fA14 i1="13"><s1>Service de Neurologie, Hôpital Gabriel Montpied</s1><s2>Clermont-Ferrand</s2><s3>FRA</s3><sZ>10 aut.</sZ></fA14><fA14 i1="14"><s1>Service de Neurologie, CHU de Grenoble</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>11 aut.</sZ></fA14><fA14 i1="15"><s1>CHU Nantes, CIC0004, Service de Neurologie</s1><s2>Nantes</s2><s3>FRA</s3><sZ>12 aut.</sZ></fA14><fA14 i1="16"><s1>Service de Neurologie, Hôpital Haut-Lévêque</s1><s2>Pessac</s2><s3>FRA</s3><sZ>13 aut.</sZ></fA14><fA14 i1="17"><s1>INSERM U708</s1><s2>Paris</s2><s3>FRA</s3><sZ>15 aut.</sZ><sZ>23 aut.</sZ></fA14><fA14 i1="18"><s1>Université Pierre et Marie Curie Paris6</s1><s2>Paris</s2><s3>FRA</s3><sZ>15 aut.</sZ><sZ>23 aut.</sZ></fA14><fA14 i1="19"><s1>UMR-S775</s1><s2>Paris</s2><s3>FRA</s3><sZ>17 aut.</sZ></fA14><fA14 i1="20"><s1>Université Paris Descartes</s1><s2>Paris</s2><s3>FRA</s3><sZ>17 aut.</sZ></fA14><fA14 i1="21"><s1>AP-HP, Hôpital Européen Georges Pompidou</s1><s2>Paris</s2><s3>FRA</s3><sZ>17 aut.</sZ></fA14><fA14 i1="22"><s1>Centre Hospitalier Dijon</s1><s2>Dijon</s2><s3>FRA</s3><sZ>18 aut.</sZ></fA14><fA14 i1="23"><s1>INSERM, CR897, Université Victor Segalen Bordeaux-2</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>19 aut.</sZ></fA14><fA14 i1="24"><s1>INSERM U888</s1><s2>Montpellier</s2><s3>FRA</s3><sZ>20 aut.</sZ></fA14><fA14 i1="25"><s1>CHRU de Lille</s1><s2>Lille</s2><s3>FRA</s3><sZ>21 aut.</sZ></fA14><fA17 i1="01" i2="1"><s1>French Parkinson's Disease Genetics Study Group</s1><s3>FRA</s3></fA17><fA20><s1>615-627</s1></fA20><fA21><s1>2011</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>22540</s2><s5>354000191994630180</s5></fA43><fA44><s0>0000</s0><s1>© 2011 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>23 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>11-0154525</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Human molecular genetics : (Print)</s0></fA64><fA66 i1="01"><s0>GBR</s0></fA66><fC01 i1="01" l="ENG"><s0>We performed a three-stage genome-wide association study (GWAS) to identify common Parkinson's disease (PD) risk variants in the European population. The initial genome-wide scan was conducted in a French sample of 1039 cases and 1984 controls, using almost 500 000 single nucleotide polymorphisms (SNPs). Two SNPs at SNCA were found to be associated with PD at the genome-wide significance level (P < 3 × 10-<sup>8</sup>). An additional set of promising and new association signals was identified and submitted for immediate replication in two independent case-control studies of subjects of European descent. We first carried out an in silico replication study using GWAS data from the WTCCC2 PD study sample (1705 cases, 5200 WTCCC controls). Nominally replicated SNPs were further genotyped in a third sample of 1527 cases and 1864 controls from France and Australia. We found converging evidence of association with PD on 12q24 (rs4964469, combined P = 2.4 × 10<sup>-7</sup>) and confirmed the association on 4p15/BST1 (rs4698412, combined P = 1.8 x 10<sup>-6</sup>), previously reported in Japanese data. The 12q24 locus includes RFX4, an isoform of which, named RFX4_v3, encodes brain-specific transcription factors that regulate many genes involved in brain morphogenesis and intracellular calcium homeostasis.</s0></fC01><fC02 i1="01" i2="X"><s0>002A04</s0></fC02><fC02 i1="02" i2="X"><s0>002A07</s0></fC02><fC02 i1="03" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Association</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Association</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Asociación</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Locus</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Locus</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Locus</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Chromosome C12</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Chromosome C12</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Cromosoma C12</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Risque</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Risk</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Riesgo</s0><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Facteur risque</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Risk factor</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Factor riesgo</s0><s5>05</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Européen</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>European</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Europeo</s0><s5>06</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Europe</s0><s2>NG</s2><s5>07</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Europe</s0><s2>NG</s2><s5>07</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Europa</s0><s2>NG</s2><s5>07</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Homme</s0><s5>08</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Human</s0><s5>08</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Hombre</s0><s5>08</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Génétique</s0><s5>09</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Genetics</s0><s5>09</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Genética</s0><s5>09</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>Maladie de Parkinson</s0><s2>NM</s2><s5>14</s5></fC03><fC03 i1="10" i2="X" l="ENG"><s0>Parkinson disease</s0><s2>NM</s2><s5>14</s5></fC03><fC03 i1="10" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s2>NM</s2><s5>14</s5></fC03><fC03 i1="11" i2="X" l="FRE"><s0>Echelle du génome</s0><s4>INC</s4><s5>88</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0><s5>19</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>19</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>19</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0><s5>20</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>20</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>20</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>21</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>21</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>21</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>22</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>22</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>22</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>23</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>23</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>23</s5></fC07><fN21><s1>101</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard><server><NO>PASCAL 11-0154525 INIST</NO><ET>Genome-wide association study confirms BST1 and suggests a locus on 12q24 as the risk loci for Parkinson's disease in the European population</ET><AU>SAAD (Mohamad); LESAGE (Suzanne); SAINT-PIERRE (Aude); CORVOL (Jean-Christophe); ZELENIKA (Diana); LAMBERT (Jean-Charles); VIDAILHET (Marie); MELLICK (George D.); LOHMANN (Ebba); DURIF (Franck); POLLAK (Pierre); DAMIER (Philippe); TISON (François); SILBURN (Peter A.); TZOURIO (Christophe); FORIANI (Sylvie); LORIOT (Marie-Anne); GIROUD (Maurice); HELMER (Catherine); PORTET (Florence); AMOUYEL (Philippe); LATHROP (Mark); ELBAZ (Alexis); DURR (Alexandra); MARTINEZ (Maria); BRICE (Alexis)</AU><AF>INSERM U563, CPTP, CHU Purpan/31024 Toulouse/France (1 aut., 3 aut., 25 aut.); Paul Sabatier University/Toulouse/France (1 aut., 3 aut., 25 aut.); Université Pierre et Marie Curie-Paris6, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UMR-S975/Paris/France (2 aut., 4 aut., 7 aut., 9 aut., 16 aut., 24 aut., 26 aut.); INSERM U975/Paris/France (2 aut., 4 aut., 7 aut., 9 aut., 16 aut., 24 aut., 26 aut.); CNRS, UMR 7225/Paris/France (2 aut., 4 aut., 7 aut., 9 aut., 16 aut., 24 aut., 26 aut.); INSERM CIC-9503, Hôpital Pitié-Salpêtrière/Paris/France (4 aut.); Centre National de Génotypage, Institut Génomique, Commissariat à l'Energie Atomique/Evry/France (5 aut., 22 aut.); INSERM U744/Lille/France (6 aut., 21 aut.); Institut Pasteur de Lille/Lille/France (6 aut., 21 aut.); Université de Lille Nord/Lille/France (6 aut., 21 aut.); National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University/Brisbane, Queensland/Australie (8 aut., 14 aut.); Department of Neurology, Princess Alexandra Hospital/Brisbane, Queensland/Australie (8 aut., 14 aut.); Service de Neurologie, Hôpital Gabriel Montpied/Clermont-Ferrand/France (10 aut.); Service de Neurologie, CHU de Grenoble/Grenoble/France (11 aut.); CHU Nantes, CIC0004, Service de Neurologie/Nantes/France (12 aut.); Service de Neurologie, Hôpital Haut-Lévêque/Pessac/France (13 aut.); INSERM U708/Paris/France (15 aut., 23 aut.); Université Pierre et Marie Curie Paris6/Paris/France (15 aut., 23 aut.); UMR-S775/Paris/France (17 aut.); Université Paris Descartes/Paris/France (17 aut.); AP-HP, Hôpital Européen Georges Pompidou/Paris/France (17 aut.); Centre Hospitalier Dijon/Dijon/France (18 aut.); INSERM, CR897, Université Victor Segalen Bordeaux-2/Bordeaux/France (19 aut.); INSERM U888/Montpellier/France (20 aut.); CHRU de Lille/Lille/France (21 aut.)</AF><DT>Publication en série; Niveau analytique</DT><SO>Human molecular genetics : (Print); ISSN 0964-6906; Royaume-Uni; Da. 2011; Vol. 20; No. 3; Pp. 615-627; Bibl. 23 ref.</SO><LA>Anglais</LA><EA>We performed a three-stage genome-wide association study (GWAS) to identify common Parkinson's disease (PD) risk variants in the European population. The initial genome-wide scan was conducted in a French sample of 1039 cases and 1984 controls, using almost 500 000 single nucleotide polymorphisms (SNPs). Two SNPs at SNCA were found to be associated with PD at the genome-wide significance level (P < 3 × 10-<sup>8</sup>). An additional set of promising and new association signals was identified and submitted for immediate replication in two independent case-control studies of subjects of European descent. We first carried out an in silico replication study using GWAS data from the WTCCC2 PD study sample (1705 cases, 5200 WTCCC controls). Nominally replicated SNPs were further genotyped in a third sample of 1527 cases and 1864 controls from France and Australia. We found converging evidence of association with PD on 12q24 (rs4964469, combined P = 2.4 × 10<sup>-7</sup>) and confirmed the association on 4p15/BST1 (rs4698412, combined P = 1.8 x 10<sup>-6</sup>), previously reported in Japanese data. The 12q24 locus includes RFX4, an isoform of which, named RFX4_v3, encodes brain-specific transcription factors that regulate many genes involved in brain morphogenesis and intracellular calcium homeostasis.</EA><CC>002A04; 002A07; 002B17G</CC><FD>Association; Locus; Chromosome C12; Risque; Facteur risque; Européen; Europe; Homme; Génétique; Maladie de Parkinson; Echelle du génome</FD><FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central; Pathologie du système nerveux</FG><ED>Association; Locus; Chromosome C12; Risk; Risk factor; European; Europe; Human; Genetics; Parkinson disease</ED><EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Nervous system diseases</EG><SD>Asociación; Locus; Cromosoma C12; Riesgo; Factor riesgo; Europeo; Europa; Hombre; Genética; Parkinson enfermedad</SD><LO>INIST-22540.354000191994630180</LO><ID>11-0154525</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
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