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Plasma Exchange for Renal Vasculitis and Idiopathic Rapidly Progressive Glomerulonephritis: A Meta-analysis

Identifieur interne : 001E28 ( PascalFrancis/Corpus ); précédent : 001E27; suivant : 001E29

Plasma Exchange for Renal Vasculitis and Idiopathic Rapidly Progressive Glomerulonephritis: A Meta-analysis

Auteurs : Michael Walsh ; Fausta Catapano ; Wladimir Szpirt ; Kristian Thorlund ; Annette Bruchfeld ; Loic Guillevin ; Marion Haubitz ; Peter A. Merkel ; CHEN AU PEH ; Charles Pusey ; David Jayne

Source :

RBID : Pascal:11-0199219

Descripteurs français

English descriptors

Abstract

Background: Plasma exchange may be effective adjunctive treatment for renal vasculitis. We performed a systematic review and meta-analysis of randomized controlled trials of plasma exchange for renal vasculitis. Study Design: Systematic review and meta-analysis of articles identified from electronic databases, bibliographies, and studies identified by experts. Data were abstracted in parallel by 2 reviewers. Setting & Population: Adults with idiopathic renal vasculitis or rapidly progressive glomerulonephritis. Selection Criteria for Studies: Randomized controlled trials that compared standard care with standard care plus adjuvant plasma exchange in adult patients with either renal vasculitis or idiopathic rapidly progressive glomerulonephritis. Intervention: Adjuvant plasma exchange. Outcome: Composite of end-stage renal disease or death. Results: We identified 9 trials including 387 patients. In a fixed-effects model, the pooled RR for end-stage renal disease or death was 0.80 for patients treated with adjunctive plasma exchange compared with standard care alone (95% CI, 0.65-0.99; P = 0.04). No significant heterogeneity was detected (P = 0.5; I2 = 0%). The effect of plasma exchange did not differ significantly across the range of baseline serum creatinine values (P = 0.7) or number of plasma exchange treatments (P = 0.8). The RR for end-stage renal disease was 0.64 (95% CI, 0.47-0.88; P= 0.006), whereas the RR for death alone was 1.01 (95% CI, 0.71-1.4; P= 0.9). Limitations: Although the primary result was statistically significant, there is insufficient statistical information to reliably determine whether plasma exchange decreases the composite of end-stage renal disease or death. Conclusions: Plasma exchange may decrease the composite end point of end-stage renal disease or death in patients with renal vasculitis. Additional trials are required given the limited data available.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

pA  
A01 01  1    @0 0272-6386
A03   1    @0 Am. j. kidney dis.
A05       @2 57
A06       @2 4
A08 01  1  ENG  @1 Plasma Exchange for Renal Vasculitis and Idiopathic Rapidly Progressive Glomerulonephritis: A Meta-analysis
A11 01  1    @1 WALSH (Michael)
A11 02  1    @1 CATAPANO (Fausta)
A11 03  1    @1 SZPIRT (Wladimir)
A11 04  1    @1 THORLUND (Kristian)
A11 05  1    @1 BRUCHFELD (Annette)
A11 06  1    @1 GUILLEVIN (Loic)
A11 07  1    @1 HAUBITZ (Marion)
A11 08  1    @1 MERKEL (Peter A.)
A11 09  1    @1 CHEN AU PEH
A11 10  1    @1 PUSEY (Charles)
A11 11  1    @1 JAYNE (David)
A14 01      @1 Department of Clinical Epidemiology and Biostatistics, McMaster University @2 Hamilton @3 CAN @Z 1 aut. @Z 4 aut.
A14 02      @1 Vasculitis and Lupus Clinic, Addenbrooke's Hospital @2 Cambridge @3 GBR @Z 1 aut. @Z 2 aut. @Z 11 aut.
A14 03      @1 Department of Nephrology, Copenhagen University Hospital, Rigshospitalet @2 Copenhagen @3 DNK @Z 3 aut.
A14 04      @1 Department of Renal Medicine, Karolinska Institute, Karolinska University Hospital @2 Stockholm @3 SWE @Z 5 aut.
A14 05      @1 Hopital Cochin, Assistance Publique, Hopitaux de Paris, Universite Paris Descartes @2 Paris @3 FRA @Z 6 aut.
A14 06      @1 Department ofNephrology and Hypertension, Hannover School of Medicine @2 Hannover @3 DEU @Z 7 aut.
A14 07      @1 Vasculitis Center, Section of Rheumatology, and the Clinical Epidemiology Unit, Boston University School of Medicine @2 Boston, MA @3 USA @Z 8 aut.
A14 08      @1 Renal Unit, Royal Adelaide Hospital @2 Adelaide @3 AUS @Z 9 aut.
A14 09      @1 Renal Section, Division of Medicine, Imperial College London, Hammersmith Hospital @2 London @3 GBR @Z 10 aut.
A20       @1 566-574
A21       @1 2011
A23 01      @0 ENG
A43 01      @1 INIST @2 19098 @5 354000192894050130
A44       @0 0000 @1 © 2011 INIST-CNRS. All rights reserved.
A45       @0 35 ref.
A47 01  1    @0 11-0199219
A60       @1 P
A61       @0 A
A64 01  1    @0 American journal of kidney diseases
A66 01      @0 USA
C01 01    ENG  @0 Background: Plasma exchange may be effective adjunctive treatment for renal vasculitis. We performed a systematic review and meta-analysis of randomized controlled trials of plasma exchange for renal vasculitis. Study Design: Systematic review and meta-analysis of articles identified from electronic databases, bibliographies, and studies identified by experts. Data were abstracted in parallel by 2 reviewers. Setting & Population: Adults with idiopathic renal vasculitis or rapidly progressive glomerulonephritis. Selection Criteria for Studies: Randomized controlled trials that compared standard care with standard care plus adjuvant plasma exchange in adult patients with either renal vasculitis or idiopathic rapidly progressive glomerulonephritis. Intervention: Adjuvant plasma exchange. Outcome: Composite of end-stage renal disease or death. Results: We identified 9 trials including 387 patients. In a fixed-effects model, the pooled RR for end-stage renal disease or death was 0.80 for patients treated with adjunctive plasma exchange compared with standard care alone (95% CI, 0.65-0.99; P = 0.04). No significant heterogeneity was detected (P = 0.5; I2 = 0%). The effect of plasma exchange did not differ significantly across the range of baseline serum creatinine values (P = 0.7) or number of plasma exchange treatments (P = 0.8). The RR for end-stage renal disease was 0.64 (95% CI, 0.47-0.88; P= 0.006), whereas the RR for death alone was 1.01 (95% CI, 0.71-1.4; P= 0.9). Limitations: Although the primary result was statistically significant, there is insufficient statistical information to reliably determine whether plasma exchange decreases the composite of end-stage renal disease or death. Conclusions: Plasma exchange may decrease the composite end point of end-stage renal disease or death in patients with renal vasculitis. Additional trials are required given the limited data available.
C02 01  X    @0 002B14A01
C02 02  X    @0 002B07
C03 01  X  FRE  @0 Echange plasmatique @5 02
C03 01  X  ENG  @0 Plasma exchange @5 02
C03 01  X  SPA  @0 Intercambio plasmático @5 02
C03 02  X  FRE  @0 Rein @5 03
C03 02  X  ENG  @0 Kidney @5 03
C03 02  X  SPA  @0 Riñón @5 03
C03 03  X  FRE  @0 Vascularite @5 05
C03 03  X  ENG  @0 Vasculitis @5 05
C03 03  X  SPA  @0 Vasculitis @5 05
C03 04  X  FRE  @0 Idiopathique @5 06
C03 04  X  ENG  @0 Idiopathic @5 06
C03 04  X  SPA  @0 Idiopático @5 06
C03 05  X  FRE  @0 Progressif @5 08
C03 05  X  ENG  @0 Progressive @5 08
C03 05  X  SPA  @0 Progresivo @5 08
C03 06  X  FRE  @0 Néphropathie glomérulaire @5 09
C03 06  X  ENG  @0 Glomerulonephritis @5 09
C03 06  X  SPA  @0 Nefropatía glomerular @5 09
C03 07  X  FRE  @0 Métaanalyse @5 11
C03 07  X  ENG  @0 Metaanalysis @5 11
C03 07  X  SPA  @0 Meta-análisis @5 11
C03 08  X  FRE  @0 Néphrologie @5 12
C03 08  X  ENG  @0 Nephrology @5 12
C03 08  X  SPA  @0 Nefrología @5 12
C03 09  X  FRE  @0 Urologie @5 17
C03 09  X  ENG  @0 Urology @5 17
C03 09  X  SPA  @0 Urología @5 17
C07 01  X  FRE  @0 Appareil urinaire @5 37
C07 01  X  ENG  @0 Urinary system @5 37
C07 01  X  SPA  @0 Aparato urinario @5 37
C07 02  X  FRE  @0 Pathologie de l'appareil circulatoire @5 38
C07 02  X  ENG  @0 Cardiovascular disease @5 38
C07 02  X  SPA  @0 Aparato circulatorio patología @5 38
C07 03  X  FRE  @0 Pathologie des vaisseaux sanguins @5 39
C07 03  X  ENG  @0 Vascular disease @5 39
C07 03  X  SPA  @0 Vaso sanguíneo patología @5 39
C07 04  X  FRE  @0 Pathologie de l'appareil urinaire @5 40
C07 04  X  ENG  @0 Urinary system disease @5 40
C07 04  X  SPA  @0 Aparato urinario patología @5 40
C07 05  X  FRE  @0 Pathologie du rein @5 41
C07 05  X  ENG  @0 Kidney disease @5 41
C07 05  X  SPA  @0 Riñón patología @5 41
N21       @1 129
N44 01      @1 OTO
N82       @1 OTO

Format Inist (serveur)

NO : PASCAL 11-0199219 INIST
ET : Plasma Exchange for Renal Vasculitis and Idiopathic Rapidly Progressive Glomerulonephritis: A Meta-analysis
AU : WALSH (Michael); CATAPANO (Fausta); SZPIRT (Wladimir); THORLUND (Kristian); BRUCHFELD (Annette); GUILLEVIN (Loic); HAUBITZ (Marion); MERKEL (Peter A.); CHEN AU PEH; PUSEY (Charles); JAYNE (David)
AF : Department of Clinical Epidemiology and Biostatistics, McMaster University/Hamilton/Canada (1 aut., 4 aut.); Vasculitis and Lupus Clinic, Addenbrooke's Hospital/Cambridge/Royaume-Uni (1 aut., 2 aut., 11 aut.); Department of Nephrology, Copenhagen University Hospital, Rigshospitalet/Copenhagen/Danemark (3 aut.); Department of Renal Medicine, Karolinska Institute, Karolinska University Hospital/Stockholm/Suède (5 aut.); Hopital Cochin, Assistance Publique, Hopitaux de Paris, Universite Paris Descartes/Paris/France (6 aut.); Department ofNephrology and Hypertension, Hannover School of Medicine/Hannover/Allemagne (7 aut.); Vasculitis Center, Section of Rheumatology, and the Clinical Epidemiology Unit, Boston University School of Medicine/Boston, MA/Etats-Unis (8 aut.); Renal Unit, Royal Adelaide Hospital/Adelaide/Australie (9 aut.); Renal Section, Division of Medicine, Imperial College London, Hammersmith Hospital/London/Royaume-Uni (10 aut.)
DT : Publication en série; Niveau analytique
SO : American journal of kidney diseases; ISSN 0272-6386; Etats-Unis; Da. 2011; Vol. 57; No. 4; Pp. 566-574; Bibl. 35 ref.
LA : Anglais
EA : Background: Plasma exchange may be effective adjunctive treatment for renal vasculitis. We performed a systematic review and meta-analysis of randomized controlled trials of plasma exchange for renal vasculitis. Study Design: Systematic review and meta-analysis of articles identified from electronic databases, bibliographies, and studies identified by experts. Data were abstracted in parallel by 2 reviewers. Setting & Population: Adults with idiopathic renal vasculitis or rapidly progressive glomerulonephritis. Selection Criteria for Studies: Randomized controlled trials that compared standard care with standard care plus adjuvant plasma exchange in adult patients with either renal vasculitis or idiopathic rapidly progressive glomerulonephritis. Intervention: Adjuvant plasma exchange. Outcome: Composite of end-stage renal disease or death. Results: We identified 9 trials including 387 patients. In a fixed-effects model, the pooled RR for end-stage renal disease or death was 0.80 for patients treated with adjunctive plasma exchange compared with standard care alone (95% CI, 0.65-0.99; P = 0.04). No significant heterogeneity was detected (P = 0.5; I2 = 0%). The effect of plasma exchange did not differ significantly across the range of baseline serum creatinine values (P = 0.7) or number of plasma exchange treatments (P = 0.8). The RR for end-stage renal disease was 0.64 (95% CI, 0.47-0.88; P= 0.006), whereas the RR for death alone was 1.01 (95% CI, 0.71-1.4; P= 0.9). Limitations: Although the primary result was statistically significant, there is insufficient statistical information to reliably determine whether plasma exchange decreases the composite of end-stage renal disease or death. Conclusions: Plasma exchange may decrease the composite end point of end-stage renal disease or death in patients with renal vasculitis. Additional trials are required given the limited data available.
CC : 002B14A01; 002B07
FD : Echange plasmatique; Rein; Vascularite; Idiopathique; Progressif; Néphropathie glomérulaire; Métaanalyse; Néphrologie; Urologie
FG : Appareil urinaire; Pathologie de l'appareil circulatoire; Pathologie des vaisseaux sanguins; Pathologie de l'appareil urinaire; Pathologie du rein
ED : Plasma exchange; Kidney; Vasculitis; Idiopathic; Progressive; Glomerulonephritis; Metaanalysis; Nephrology; Urology
EG : Urinary system; Cardiovascular disease; Vascular disease; Urinary system disease; Kidney disease
SD : Intercambio plasmático; Riñón; Vasculitis; Idiopático; Progresivo; Nefropatía glomerular; Meta-análisis; Nefrología; Urología
LO : INIST-19098.354000192894050130
ID : 11-0199219

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Pascal:11-0199219

Le document en format XML

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<s1>Department ofNephrology and Hypertension, Hannover School of Medicine</s1>
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</inist:fA14>
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<name sortKey="Merkel, Peter A" sort="Merkel, Peter A" uniqKey="Merkel P" first="Peter A." last="Merkel">Peter A. Merkel</name>
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</inist:fA14>
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<author>
<name sortKey="Chen Au Peh" sort="Chen Au Peh" uniqKey="Chen Au Peh" last="Chen Au Peh">CHEN AU PEH</name>
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</inist:fA14>
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<name sortKey="Jayne, David" sort="Jayne, David" uniqKey="Jayne D" first="David" last="Jayne">David Jayne</name>
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<title level="j" type="main">American journal of kidney diseases</title>
<title level="j" type="abbreviated">Am. j. kidney dis.</title>
<idno type="ISSN">0272-6386</idno>
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<title level="j" type="main">American journal of kidney diseases</title>
<title level="j" type="abbreviated">Am. j. kidney dis.</title>
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<term>Glomerulonephritis</term>
<term>Idiopathic</term>
<term>Kidney</term>
<term>Metaanalysis</term>
<term>Nephrology</term>
<term>Plasma exchange</term>
<term>Progressive</term>
<term>Urology</term>
<term>Vasculitis</term>
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<term>Echange plasmatique</term>
<term>Rein</term>
<term>Vascularite</term>
<term>Idiopathique</term>
<term>Progressif</term>
<term>Néphropathie glomérulaire</term>
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<div type="abstract" xml:lang="en">Background: Plasma exchange may be effective adjunctive treatment for renal vasculitis. We performed a systematic review and meta-analysis of randomized controlled trials of plasma exchange for renal vasculitis. Study Design: Systematic review and meta-analysis of articles identified from electronic databases, bibliographies, and studies identified by experts. Data were abstracted in parallel by 2 reviewers. Setting & Population: Adults with idiopathic renal vasculitis or rapidly progressive glomerulonephritis. Selection Criteria for Studies: Randomized controlled trials that compared standard care with standard care plus adjuvant plasma exchange in adult patients with either renal vasculitis or idiopathic rapidly progressive glomerulonephritis. Intervention: Adjuvant plasma exchange. Outcome: Composite of end-stage renal disease or death. Results: We identified 9 trials including 387 patients. In a fixed-effects model, the pooled RR for end-stage renal disease or death was 0.80 for patients treated with adjunctive plasma exchange compared with standard care alone (95% CI, 0.65-0.99; P = 0.04). No significant heterogeneity was detected (P = 0.5; I
<sup>2</sup>
= 0%). The effect of plasma exchange did not differ significantly across the range of baseline serum creatinine values (P = 0.7) or number of plasma exchange treatments (P = 0.8). The RR for end-stage renal disease was 0.64 (95% CI, 0.47-0.88; P= 0.006), whereas the RR for death alone was 1.01 (95% CI, 0.71-1.4; P= 0.9). Limitations: Although the primary result was statistically significant, there is insufficient statistical information to reliably determine whether plasma exchange decreases the composite of end-stage renal disease or death. Conclusions: Plasma exchange may decrease the composite end point of end-stage renal disease or death in patients with renal vasculitis. Additional trials are required given the limited data available.</div>
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<sup>2</sup>
= 0%). The effect of plasma exchange did not differ significantly across the range of baseline serum creatinine values (P = 0.7) or number of plasma exchange treatments (P = 0.8). The RR for end-stage renal disease was 0.64 (95% CI, 0.47-0.88; P= 0.006), whereas the RR for death alone was 1.01 (95% CI, 0.71-1.4; P= 0.9). Limitations: Although the primary result was statistically significant, there is insufficient statistical information to reliably determine whether plasma exchange decreases the composite of end-stage renal disease or death. Conclusions: Plasma exchange may decrease the composite end point of end-stage renal disease or death in patients with renal vasculitis. Additional trials are required given the limited data available.</s0>
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<ET>Plasma Exchange for Renal Vasculitis and Idiopathic Rapidly Progressive Glomerulonephritis: A Meta-analysis</ET>
<AU>WALSH (Michael); CATAPANO (Fausta); SZPIRT (Wladimir); THORLUND (Kristian); BRUCHFELD (Annette); GUILLEVIN (Loic); HAUBITZ (Marion); MERKEL (Peter A.); CHEN AU PEH; PUSEY (Charles); JAYNE (David)</AU>
<AF>Department of Clinical Epidemiology and Biostatistics, McMaster University/Hamilton/Canada (1 aut., 4 aut.); Vasculitis and Lupus Clinic, Addenbrooke's Hospital/Cambridge/Royaume-Uni (1 aut., 2 aut., 11 aut.); Department of Nephrology, Copenhagen University Hospital, Rigshospitalet/Copenhagen/Danemark (3 aut.); Department of Renal Medicine, Karolinska Institute, Karolinska University Hospital/Stockholm/Suède (5 aut.); Hopital Cochin, Assistance Publique, Hopitaux de Paris, Universite Paris Descartes/Paris/France (6 aut.); Department ofNephrology and Hypertension, Hannover School of Medicine/Hannover/Allemagne (7 aut.); Vasculitis Center, Section of Rheumatology, and the Clinical Epidemiology Unit, Boston University School of Medicine/Boston, MA/Etats-Unis (8 aut.); Renal Unit, Royal Adelaide Hospital/Adelaide/Australie (9 aut.); Renal Section, Division of Medicine, Imperial College London, Hammersmith Hospital/London/Royaume-Uni (10 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>American journal of kidney diseases; ISSN 0272-6386; Etats-Unis; Da. 2011; Vol. 57; No. 4; Pp. 566-574; Bibl. 35 ref.</SO>
<LA>Anglais</LA>
<EA>Background: Plasma exchange may be effective adjunctive treatment for renal vasculitis. We performed a systematic review and meta-analysis of randomized controlled trials of plasma exchange for renal vasculitis. Study Design: Systematic review and meta-analysis of articles identified from electronic databases, bibliographies, and studies identified by experts. Data were abstracted in parallel by 2 reviewers. Setting & Population: Adults with idiopathic renal vasculitis or rapidly progressive glomerulonephritis. Selection Criteria for Studies: Randomized controlled trials that compared standard care with standard care plus adjuvant plasma exchange in adult patients with either renal vasculitis or idiopathic rapidly progressive glomerulonephritis. Intervention: Adjuvant plasma exchange. Outcome: Composite of end-stage renal disease or death. Results: We identified 9 trials including 387 patients. In a fixed-effects model, the pooled RR for end-stage renal disease or death was 0.80 for patients treated with adjunctive plasma exchange compared with standard care alone (95% CI, 0.65-0.99; P = 0.04). No significant heterogeneity was detected (P = 0.5; I
<sup>2</sup>
= 0%). The effect of plasma exchange did not differ significantly across the range of baseline serum creatinine values (P = 0.7) or number of plasma exchange treatments (P = 0.8). The RR for end-stage renal disease was 0.64 (95% CI, 0.47-0.88; P= 0.006), whereas the RR for death alone was 1.01 (95% CI, 0.71-1.4; P= 0.9). Limitations: Although the primary result was statistically significant, there is insufficient statistical information to reliably determine whether plasma exchange decreases the composite of end-stage renal disease or death. Conclusions: Plasma exchange may decrease the composite end point of end-stage renal disease or death in patients with renal vasculitis. Additional trials are required given the limited data available.</EA>
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<ED>Plasma exchange; Kidney; Vasculitis; Idiopathic; Progressive; Glomerulonephritis; Metaanalysis; Nephrology; Urology</ED>
<EG>Urinary system; Cardiovascular disease; Vascular disease; Urinary system disease; Kidney disease</EG>
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