Plasma Exchange for Renal Vasculitis and Idiopathic Rapidly Progressive Glomerulonephritis: A Meta-analysis
Identifieur interne : 001E28 ( PascalFrancis/Corpus ); précédent : 001E27; suivant : 001E29Plasma Exchange for Renal Vasculitis and Idiopathic Rapidly Progressive Glomerulonephritis: A Meta-analysis
Auteurs : Michael Walsh ; Fausta Catapano ; Wladimir Szpirt ; Kristian Thorlund ; Annette Bruchfeld ; Loic Guillevin ; Marion Haubitz ; Peter A. Merkel ; CHEN AU PEH ; Charles Pusey ; David JayneSource :
- American journal of kidney diseases [ 0272-6386 ] ; 2011.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Background: Plasma exchange may be effective adjunctive treatment for renal vasculitis. We performed a systematic review and meta-analysis of randomized controlled trials of plasma exchange for renal vasculitis. Study Design: Systematic review and meta-analysis of articles identified from electronic databases, bibliographies, and studies identified by experts. Data were abstracted in parallel by 2 reviewers. Setting & Population: Adults with idiopathic renal vasculitis or rapidly progressive glomerulonephritis. Selection Criteria for Studies: Randomized controlled trials that compared standard care with standard care plus adjuvant plasma exchange in adult patients with either renal vasculitis or idiopathic rapidly progressive glomerulonephritis. Intervention: Adjuvant plasma exchange. Outcome: Composite of end-stage renal disease or death. Results: We identified 9 trials including 387 patients. In a fixed-effects model, the pooled RR for end-stage renal disease or death was 0.80 for patients treated with adjunctive plasma exchange compared with standard care alone (95% CI, 0.65-0.99; P = 0.04). No significant heterogeneity was detected (P = 0.5; I2 = 0%). The effect of plasma exchange did not differ significantly across the range of baseline serum creatinine values (P = 0.7) or number of plasma exchange treatments (P = 0.8). The RR for end-stage renal disease was 0.64 (95% CI, 0.47-0.88; P= 0.006), whereas the RR for death alone was 1.01 (95% CI, 0.71-1.4; P= 0.9). Limitations: Although the primary result was statistically significant, there is insufficient statistical information to reliably determine whether plasma exchange decreases the composite of end-stage renal disease or death. Conclusions: Plasma exchange may decrease the composite end point of end-stage renal disease or death in patients with renal vasculitis. Additional trials are required given the limited data available.
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Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 11-0199219 INIST |
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ET : | Plasma Exchange for Renal Vasculitis and Idiopathic Rapidly Progressive Glomerulonephritis: A Meta-analysis |
AU : | WALSH (Michael); CATAPANO (Fausta); SZPIRT (Wladimir); THORLUND (Kristian); BRUCHFELD (Annette); GUILLEVIN (Loic); HAUBITZ (Marion); MERKEL (Peter A.); CHEN AU PEH; PUSEY (Charles); JAYNE (David) |
AF : | Department of Clinical Epidemiology and Biostatistics, McMaster University/Hamilton/Canada (1 aut., 4 aut.); Vasculitis and Lupus Clinic, Addenbrooke's Hospital/Cambridge/Royaume-Uni (1 aut., 2 aut., 11 aut.); Department of Nephrology, Copenhagen University Hospital, Rigshospitalet/Copenhagen/Danemark (3 aut.); Department of Renal Medicine, Karolinska Institute, Karolinska University Hospital/Stockholm/Suède (5 aut.); Hopital Cochin, Assistance Publique, Hopitaux de Paris, Universite Paris Descartes/Paris/France (6 aut.); Department ofNephrology and Hypertension, Hannover School of Medicine/Hannover/Allemagne (7 aut.); Vasculitis Center, Section of Rheumatology, and the Clinical Epidemiology Unit, Boston University School of Medicine/Boston, MA/Etats-Unis (8 aut.); Renal Unit, Royal Adelaide Hospital/Adelaide/Australie (9 aut.); Renal Section, Division of Medicine, Imperial College London, Hammersmith Hospital/London/Royaume-Uni (10 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | American journal of kidney diseases; ISSN 0272-6386; Etats-Unis; Da. 2011; Vol. 57; No. 4; Pp. 566-574; Bibl. 35 ref. |
LA : | Anglais |
EA : | Background: Plasma exchange may be effective adjunctive treatment for renal vasculitis. We performed a systematic review and meta-analysis of randomized controlled trials of plasma exchange for renal vasculitis. Study Design: Systematic review and meta-analysis of articles identified from electronic databases, bibliographies, and studies identified by experts. Data were abstracted in parallel by 2 reviewers. Setting & Population: Adults with idiopathic renal vasculitis or rapidly progressive glomerulonephritis. Selection Criteria for Studies: Randomized controlled trials that compared standard care with standard care plus adjuvant plasma exchange in adult patients with either renal vasculitis or idiopathic rapidly progressive glomerulonephritis. Intervention: Adjuvant plasma exchange. Outcome: Composite of end-stage renal disease or death. Results: We identified 9 trials including 387 patients. In a fixed-effects model, the pooled RR for end-stage renal disease or death was 0.80 for patients treated with adjunctive plasma exchange compared with standard care alone (95% CI, 0.65-0.99; P = 0.04). No significant heterogeneity was detected (P = 0.5; I2 = 0%). The effect of plasma exchange did not differ significantly across the range of baseline serum creatinine values (P = 0.7) or number of plasma exchange treatments (P = 0.8). The RR for end-stage renal disease was 0.64 (95% CI, 0.47-0.88; P= 0.006), whereas the RR for death alone was 1.01 (95% CI, 0.71-1.4; P= 0.9). Limitations: Although the primary result was statistically significant, there is insufficient statistical information to reliably determine whether plasma exchange decreases the composite of end-stage renal disease or death. Conclusions: Plasma exchange may decrease the composite end point of end-stage renal disease or death in patients with renal vasculitis. Additional trials are required given the limited data available. |
CC : | 002B14A01; 002B07 |
FD : | Echange plasmatique; Rein; Vascularite; Idiopathique; Progressif; Néphropathie glomérulaire; Métaanalyse; Néphrologie; Urologie |
FG : | Appareil urinaire; Pathologie de l'appareil circulatoire; Pathologie des vaisseaux sanguins; Pathologie de l'appareil urinaire; Pathologie du rein |
ED : | Plasma exchange; Kidney; Vasculitis; Idiopathic; Progressive; Glomerulonephritis; Metaanalysis; Nephrology; Urology |
EG : | Urinary system; Cardiovascular disease; Vascular disease; Urinary system disease; Kidney disease |
SD : | Intercambio plasmático; Riñón; Vasculitis; Idiopático; Progresivo; Nefropatía glomerular; Meta-análisis; Nefrología; Urología |
LO : | INIST-19098.354000192894050130 |
ID : | 11-0199219 |
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Pascal:11-0199219Le document en format XML
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<author><name sortKey="Merkel, Peter A" sort="Merkel, Peter A" uniqKey="Merkel P" first="Peter A." last="Merkel">Peter A. Merkel</name>
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<s2>Boston, MA</s2>
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<sZ>8 aut.</sZ>
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<author><name sortKey="Chen Au Peh" sort="Chen Au Peh" uniqKey="Chen Au Peh" last="Chen Au Peh">CHEN AU PEH</name>
<affiliation><inist:fA14 i1="08"><s1>Renal Unit, Royal Adelaide Hospital</s1>
<s2>Adelaide</s2>
<s3>AUS</s3>
<sZ>9 aut.</sZ>
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<author><name sortKey="Pusey, Charles" sort="Pusey, Charles" uniqKey="Pusey C" first="Charles" last="Pusey">Charles Pusey</name>
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<s2>London</s2>
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<author><name sortKey="Jayne, David" sort="Jayne, David" uniqKey="Jayne D" first="David" last="Jayne">David Jayne</name>
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<s2>Cambridge</s2>
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<sZ>2 aut.</sZ>
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<series><title level="j" type="main">American journal of kidney diseases</title>
<title level="j" type="abbreviated">Am. j. kidney dis.</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Glomerulonephritis</term>
<term>Idiopathic</term>
<term>Kidney</term>
<term>Metaanalysis</term>
<term>Nephrology</term>
<term>Plasma exchange</term>
<term>Progressive</term>
<term>Urology</term>
<term>Vasculitis</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Echange plasmatique</term>
<term>Rein</term>
<term>Vascularite</term>
<term>Idiopathique</term>
<term>Progressif</term>
<term>Néphropathie glomérulaire</term>
<term>Métaanalyse</term>
<term>Néphrologie</term>
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<front><div type="abstract" xml:lang="en">Background: Plasma exchange may be effective adjunctive treatment for renal vasculitis. We performed a systematic review and meta-analysis of randomized controlled trials of plasma exchange for renal vasculitis. Study Design: Systematic review and meta-analysis of articles identified from electronic databases, bibliographies, and studies identified by experts. Data were abstracted in parallel by 2 reviewers. Setting & Population: Adults with idiopathic renal vasculitis or rapidly progressive glomerulonephritis. Selection Criteria for Studies: Randomized controlled trials that compared standard care with standard care plus adjuvant plasma exchange in adult patients with either renal vasculitis or idiopathic rapidly progressive glomerulonephritis. Intervention: Adjuvant plasma exchange. Outcome: Composite of end-stage renal disease or death. Results: We identified 9 trials including 387 patients. In a fixed-effects model, the pooled RR for end-stage renal disease or death was 0.80 for patients treated with adjunctive plasma exchange compared with standard care alone (95% CI, 0.65-0.99; P = 0.04). No significant heterogeneity was detected (P = 0.5; I<sup>2</sup>
= 0%). The effect of plasma exchange did not differ significantly across the range of baseline serum creatinine values (P = 0.7) or number of plasma exchange treatments (P = 0.8). The RR for end-stage renal disease was 0.64 (95% CI, 0.47-0.88; P= 0.006), whereas the RR for death alone was 1.01 (95% CI, 0.71-1.4; P= 0.9). Limitations: Although the primary result was statistically significant, there is insufficient statistical information to reliably determine whether plasma exchange decreases the composite of end-stage renal disease or death. Conclusions: Plasma exchange may decrease the composite end point of end-stage renal disease or death in patients with renal vasculitis. Additional trials are required given the limited data available.</div>
</front>
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<s3>FRA</s3>
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<fA14 i1="06"><s1>Department ofNephrology and Hypertension, Hannover School of Medicine</s1>
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<fA14 i1="07"><s1>Vasculitis Center, Section of Rheumatology, and the Clinical Epidemiology Unit, Boston University School of Medicine</s1>
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<fA64 i1="01" i2="1"><s0>American journal of kidney diseases</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Background: Plasma exchange may be effective adjunctive treatment for renal vasculitis. We performed a systematic review and meta-analysis of randomized controlled trials of plasma exchange for renal vasculitis. Study Design: Systematic review and meta-analysis of articles identified from electronic databases, bibliographies, and studies identified by experts. Data were abstracted in parallel by 2 reviewers. Setting & Population: Adults with idiopathic renal vasculitis or rapidly progressive glomerulonephritis. Selection Criteria for Studies: Randomized controlled trials that compared standard care with standard care plus adjuvant plasma exchange in adult patients with either renal vasculitis or idiopathic rapidly progressive glomerulonephritis. Intervention: Adjuvant plasma exchange. Outcome: Composite of end-stage renal disease or death. Results: We identified 9 trials including 387 patients. In a fixed-effects model, the pooled RR for end-stage renal disease or death was 0.80 for patients treated with adjunctive plasma exchange compared with standard care alone (95% CI, 0.65-0.99; P = 0.04). No significant heterogeneity was detected (P = 0.5; I<sup>2</sup>
= 0%). The effect of plasma exchange did not differ significantly across the range of baseline serum creatinine values (P = 0.7) or number of plasma exchange treatments (P = 0.8). The RR for end-stage renal disease was 0.64 (95% CI, 0.47-0.88; P= 0.006), whereas the RR for death alone was 1.01 (95% CI, 0.71-1.4; P= 0.9). Limitations: Although the primary result was statistically significant, there is insufficient statistical information to reliably determine whether plasma exchange decreases the composite of end-stage renal disease or death. Conclusions: Plasma exchange may decrease the composite end point of end-stage renal disease or death in patients with renal vasculitis. Additional trials are required given the limited data available.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B14A01</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B07</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Echange plasmatique</s0>
<s5>02</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Plasma exchange</s0>
<s5>02</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Intercambio plasmático</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Rein</s0>
<s5>03</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Kidney</s0>
<s5>03</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Riñón</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Vascularite</s0>
<s5>05</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Vasculitis</s0>
<s5>05</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Vasculitis</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Idiopathique</s0>
<s5>06</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Idiopathic</s0>
<s5>06</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Idiopático</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Progressif</s0>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Progressive</s0>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Progresivo</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Néphropathie glomérulaire</s0>
<s5>09</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Glomerulonephritis</s0>
<s5>09</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Nefropatía glomerular</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Métaanalyse</s0>
<s5>11</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Metaanalysis</s0>
<s5>11</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Meta-análisis</s0>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Néphrologie</s0>
<s5>12</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Nephrology</s0>
<s5>12</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Nefrología</s0>
<s5>12</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Urologie</s0>
<s5>17</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Urology</s0>
<s5>17</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Urología</s0>
<s5>17</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Appareil urinaire</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Urinary system</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Aparato urinario</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Pathologie de l'appareil circulatoire</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Cardiovascular disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Aparato circulatorio patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Pathologie des vaisseaux sanguins</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Vascular disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Vaso sanguíneo patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Pathologie de l'appareil urinaire</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Urinary system disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Aparato urinario patología</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Pathologie du rein</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Kidney disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Riñón patología</s0>
<s5>41</s5>
</fC07>
<fN21><s1>129</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 11-0199219 INIST</NO>
<ET>Plasma Exchange for Renal Vasculitis and Idiopathic Rapidly Progressive Glomerulonephritis: A Meta-analysis</ET>
<AU>WALSH (Michael); CATAPANO (Fausta); SZPIRT (Wladimir); THORLUND (Kristian); BRUCHFELD (Annette); GUILLEVIN (Loic); HAUBITZ (Marion); MERKEL (Peter A.); CHEN AU PEH; PUSEY (Charles); JAYNE (David)</AU>
<AF>Department of Clinical Epidemiology and Biostatistics, McMaster University/Hamilton/Canada (1 aut., 4 aut.); Vasculitis and Lupus Clinic, Addenbrooke's Hospital/Cambridge/Royaume-Uni (1 aut., 2 aut., 11 aut.); Department of Nephrology, Copenhagen University Hospital, Rigshospitalet/Copenhagen/Danemark (3 aut.); Department of Renal Medicine, Karolinska Institute, Karolinska University Hospital/Stockholm/Suède (5 aut.); Hopital Cochin, Assistance Publique, Hopitaux de Paris, Universite Paris Descartes/Paris/France (6 aut.); Department ofNephrology and Hypertension, Hannover School of Medicine/Hannover/Allemagne (7 aut.); Vasculitis Center, Section of Rheumatology, and the Clinical Epidemiology Unit, Boston University School of Medicine/Boston, MA/Etats-Unis (8 aut.); Renal Unit, Royal Adelaide Hospital/Adelaide/Australie (9 aut.); Renal Section, Division of Medicine, Imperial College London, Hammersmith Hospital/London/Royaume-Uni (10 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>American journal of kidney diseases; ISSN 0272-6386; Etats-Unis; Da. 2011; Vol. 57; No. 4; Pp. 566-574; Bibl. 35 ref.</SO>
<LA>Anglais</LA>
<EA>Background: Plasma exchange may be effective adjunctive treatment for renal vasculitis. We performed a systematic review and meta-analysis of randomized controlled trials of plasma exchange for renal vasculitis. Study Design: Systematic review and meta-analysis of articles identified from electronic databases, bibliographies, and studies identified by experts. Data were abstracted in parallel by 2 reviewers. Setting & Population: Adults with idiopathic renal vasculitis or rapidly progressive glomerulonephritis. Selection Criteria for Studies: Randomized controlled trials that compared standard care with standard care plus adjuvant plasma exchange in adult patients with either renal vasculitis or idiopathic rapidly progressive glomerulonephritis. Intervention: Adjuvant plasma exchange. Outcome: Composite of end-stage renal disease or death. Results: We identified 9 trials including 387 patients. In a fixed-effects model, the pooled RR for end-stage renal disease or death was 0.80 for patients treated with adjunctive plasma exchange compared with standard care alone (95% CI, 0.65-0.99; P = 0.04). No significant heterogeneity was detected (P = 0.5; I<sup>2</sup>
= 0%). The effect of plasma exchange did not differ significantly across the range of baseline serum creatinine values (P = 0.7) or number of plasma exchange treatments (P = 0.8). The RR for end-stage renal disease was 0.64 (95% CI, 0.47-0.88; P= 0.006), whereas the RR for death alone was 1.01 (95% CI, 0.71-1.4; P= 0.9). Limitations: Although the primary result was statistically significant, there is insufficient statistical information to reliably determine whether plasma exchange decreases the composite of end-stage renal disease or death. Conclusions: Plasma exchange may decrease the composite end point of end-stage renal disease or death in patients with renal vasculitis. Additional trials are required given the limited data available.</EA>
<CC>002B14A01; 002B07</CC>
<FD>Echange plasmatique; Rein; Vascularite; Idiopathique; Progressif; Néphropathie glomérulaire; Métaanalyse; Néphrologie; Urologie</FD>
<FG>Appareil urinaire; Pathologie de l'appareil circulatoire; Pathologie des vaisseaux sanguins; Pathologie de l'appareil urinaire; Pathologie du rein</FG>
<ED>Plasma exchange; Kidney; Vasculitis; Idiopathic; Progressive; Glomerulonephritis; Metaanalysis; Nephrology; Urology</ED>
<EG>Urinary system; Cardiovascular disease; Vascular disease; Urinary system disease; Kidney disease</EG>
<SD>Intercambio plasmático; Riñón; Vasculitis; Idiopático; Progresivo; Nefropatía glomerular; Meta-análisis; Nefrología; Urología</SD>
<LO>INIST-19098.354000192894050130</LO>
<ID>11-0199219</ID>
</server>
</inist>
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