Assessing the infrequent oral supplementation of olanzapine long-acting injection in the treatment of schizophrenia
Identifieur interne : 001A83 ( PascalFrancis/Corpus ); précédent : 001A82; suivant : 001A84Assessing the infrequent oral supplementation of olanzapine long-acting injection in the treatment of schizophrenia
Auteurs : H. Ascher-Svanum ; X. Peng ; W. Montgomery ; D. E. Faries ; A. H. Lawson ; M. M. Witte ; D. Novick ; N. Jemiai ; E. Perrin ; D. P. McdonnellSource :
- European psychiatry [ 0924-9338 ] ; 2011.
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- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Objective: Adding another antipsychotic to a treatment regimen was previously used in evaluating the medication's efficacy. Supplementation of depot antipsychotics with oral antipsychotics is particularly meaningful because depot formulations are typically chosen for patients struggling with adherence to oral antipsychotics. This post-hoc analysis assessed supplementation of olanzapine long-acting injection (olanzapine-LAI) with oral olanzapine. Subjects and methods: We used 12 months of data from an open-label, single-arm extension study of patients with schizophrenia or schizoaffective disorder (N = 931) treated with olanzapine-LAI. The prevalence, duration, time to first supplementation, and best predictors of oral supplementation were assessed. Results: Oral supplementation occurred in 2 1 % of patients for a median of 31 days with mean modal dose of 10.8 mg/day. Mean time to first supplementation was shorter for patients who were at least moderately ill at baseline compared to less ill patients (47 vs. 97 days, p < 0.001 Best predictors of oral supplementation included a more severe illness profile at baseline, lower olanzapine-LAI dose prior to oral supplementation, supervised living arrangements, and being African-American. Conclusion: Supplementation of olanzapine-LAI appears to be infrequent, of relatively short duration, and reserved for more severely ill patients who may require a targeted rescue medication due to signs of impending relapse.
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Format Inist (serveur)
NO : | PASCAL 11-0339142 INIST |
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ET : | Assessing the infrequent oral supplementation of olanzapine long-acting injection in the treatment of schizophrenia |
AU : | ASCHER-SVANUM (H.); PENG (X.); MONTGOMERY (W.); FARIES (D. E.); LAWSON (A. H.); WITTE (M. M.); NOVICK (D.); JEMIAI (N.); PERRIN (E.); MCDONNELL (D. P.) |
AF : | Lilly Corporate Center, DC 4133, Eli Lilly and Company/Indianapolis, IN 46285/Etats-Unis (1 aut., 2 aut., 5 aut.); Eli Lilly Australia Pty Ltd, 112, Wharf Road/West Ryde NSW 2114/Australie (3 aut.); Lilly USA, LLC, Lilly Corporate Center, DC 4133/Indianapolis, IN 46285/Etats-Unis (6 aut.); Eli Lilly and Company Limited, Lilly Research Centre, Erl Wood Manor, Sunninghill Road, Windlesham/Surrey, GU20 6PH/Royaume-Uni (7 aut., 8 aut.); Eli Lilly and Company Limited, 13, rue Pagès/92158 Suresnes/France (9 aut.); Eli Lilly and Company Limited, Cork ELCL/DC 6158/Royaume-Uni (10 aut.); Eli Lilly and Company, Lilly Corporate Center, Drop Code 5024/Indianapolis, IN 46285/Etats-Unis (4 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | European psychiatry; ISSN 0924-9338; France; Da. 2011; Vol. 26; No. 5; Pp. 313-319; Bibl. 33 ref. |
LA : | Anglais |
EA : | Objective: Adding another antipsychotic to a treatment regimen was previously used in evaluating the medication's efficacy. Supplementation of depot antipsychotics with oral antipsychotics is particularly meaningful because depot formulations are typically chosen for patients struggling with adherence to oral antipsychotics. This post-hoc analysis assessed supplementation of olanzapine long-acting injection (olanzapine-LAI) with oral olanzapine. Subjects and methods: We used 12 months of data from an open-label, single-arm extension study of patients with schizophrenia or schizoaffective disorder (N = 931) treated with olanzapine-LAI. The prevalence, duration, time to first supplementation, and best predictors of oral supplementation were assessed. Results: Oral supplementation occurred in 2 1 % of patients for a median of 31 days with mean modal dose of 10.8 mg/day. Mean time to first supplementation was shorter for patients who were at least moderately ill at baseline compared to less ill patients (47 vs. 97 days, p < 0.001 Best predictors of oral supplementation included a more severe illness profile at baseline, lower olanzapine-LAI dose prior to oral supplementation, supervised living arrangements, and being African-American. Conclusion: Supplementation of olanzapine-LAI appears to be infrequent, of relatively short duration, and reserved for more severely ill patients who may require a targeted rescue medication due to signs of impending relapse. |
CC : | 002B18C06A; 002B02B03 |
FD : | Evaluation; Voie orale; Neuroleptique; Olanzapine; Forme libération contrôlée; Traitement; Schizophrénie; Psychotrope; Antipsychotique atypique; Forme pharmaceutique |
FG : | Antagoniste dopamine; Antagoniste sérotonine; Dérivé de la dibenzodiazépine; Récepteur dopaminergique D2; Récepteur sérotoninergique; Dérivé de la thiénobenzodiazépine; Psychose |
ED : | Evaluation; Oral administration; Neuroleptic; Olanzapine; Controlled release form; Treatment; Schizophrenia; Psychotropic; Atypical antipsychotic; Dosage form |
EG : | Dopamine antagonist; Serotonin antagonist; Dibenzodiazepine derivatives; D2 Dopamine receptor; Serotonine receptor; Thienobenzodiazepine derivatives; Psychosis |
SD : | Evaluación; Vía oral; Neuroléptico; Olanzapina; Forma liberación controlada; Tratamiento; Esquizofrenia; Psicotropo; Antipsicótico atípico; Forma farmacéutica |
LO : | INIST-21224.354000509415590080 |
ID : | 11-0339142 |
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<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Olanzapine</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Olanzapina</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Forme libération contrôlée</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Controlled release form</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Forma liberación controlada</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Traitement</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Treatment</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Tratamiento</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Schizophrénie</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Schizophrenia</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Esquizofrenia</s0>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Psychotrope</s0>
<s2>FX</s2>
<s5>31</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Psychotropic</s0>
<s2>FX</s2>
<s5>31</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Psicotropo</s0>
<s2>FX</s2>
<s5>31</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Antipsychotique atypique</s0>
<s5>32</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Atypical antipsychotic</s0>
<s5>32</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Antipsicótico atípico</s0>
<s5>32</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Forme pharmaceutique</s0>
<s5>33</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Dosage form</s0>
<s5>33</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Forma farmacéutica</s0>
<s5>33</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Antagoniste dopamine</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Dopamine antagonist</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Antagonista dopamina</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Antagoniste sérotonine</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Serotonin antagonist</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Antagonista serotonina</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Dérivé de la dibenzodiazépine</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Dibenzodiazepine derivatives</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Dibenzodiazepina derivado</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Récepteur dopaminergique D2</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>D2 Dopamine receptor</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Receptor dopaminérgico D2</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Récepteur sérotoninergique</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Serotonine receptor</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Receptor serotoninérgico</s0>
<s5>41</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Dérivé de la thiénobenzodiazépine</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Thienobenzodiazepine derivatives</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Tienobenzodiazepina derivado</s0>
<s5>42</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Psychose</s0>
<s5>43</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Psychosis</s0>
<s5>43</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Psicosis</s0>
<s5>43</s5>
</fC07>
<fN21><s1>234</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
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<server><NO>PASCAL 11-0339142 INIST</NO>
<ET>Assessing the infrequent oral supplementation of olanzapine long-acting injection in the treatment of schizophrenia</ET>
<AU>ASCHER-SVANUM (H.); PENG (X.); MONTGOMERY (W.); FARIES (D. E.); LAWSON (A. H.); WITTE (M. M.); NOVICK (D.); JEMIAI (N.); PERRIN (E.); MCDONNELL (D. P.)</AU>
<AF>Lilly Corporate Center, DC 4133, Eli Lilly and Company/Indianapolis, IN 46285/Etats-Unis (1 aut., 2 aut., 5 aut.); Eli Lilly Australia Pty Ltd, 112, Wharf Road/West Ryde NSW 2114/Australie (3 aut.); Lilly USA, LLC, Lilly Corporate Center, DC 4133/Indianapolis, IN 46285/Etats-Unis (6 aut.); Eli Lilly and Company Limited, Lilly Research Centre, Erl Wood Manor, Sunninghill Road, Windlesham/Surrey, GU20 6PH/Royaume-Uni (7 aut., 8 aut.); Eli Lilly and Company Limited, 13, rue Pagès/92158 Suresnes/France (9 aut.); Eli Lilly and Company Limited, Cork ELCL/DC 6158/Royaume-Uni (10 aut.); Eli Lilly and Company, Lilly Corporate Center, Drop Code 5024/Indianapolis, IN 46285/Etats-Unis (4 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>European psychiatry; ISSN 0924-9338; France; Da. 2011; Vol. 26; No. 5; Pp. 313-319; Bibl. 33 ref.</SO>
<LA>Anglais</LA>
<EA>Objective: Adding another antipsychotic to a treatment regimen was previously used in evaluating the medication's efficacy. Supplementation of depot antipsychotics with oral antipsychotics is particularly meaningful because depot formulations are typically chosen for patients struggling with adherence to oral antipsychotics. This post-hoc analysis assessed supplementation of olanzapine long-acting injection (olanzapine-LAI) with oral olanzapine. Subjects and methods: We used 12 months of data from an open-label, single-arm extension study of patients with schizophrenia or schizoaffective disorder (N = 931) treated with olanzapine-LAI. The prevalence, duration, time to first supplementation, and best predictors of oral supplementation were assessed. Results: Oral supplementation occurred in 2 1 % of patients for a median of 31 days with mean modal dose of 10.8 mg/day. Mean time to first supplementation was shorter for patients who were at least moderately ill at baseline compared to less ill patients (47 vs. 97 days, p < 0.001 Best predictors of oral supplementation included a more severe illness profile at baseline, lower olanzapine-LAI dose prior to oral supplementation, supervised living arrangements, and being African-American. Conclusion: Supplementation of olanzapine-LAI appears to be infrequent, of relatively short duration, and reserved for more severely ill patients who may require a targeted rescue medication due to signs of impending relapse.</EA>
<CC>002B18C06A; 002B02B03</CC>
<FD>Evaluation; Voie orale; Neuroleptique; Olanzapine; Forme libération contrôlée; Traitement; Schizophrénie; Psychotrope; Antipsychotique atypique; Forme pharmaceutique</FD>
<FG>Antagoniste dopamine; Antagoniste sérotonine; Dérivé de la dibenzodiazépine; Récepteur dopaminergique D2; Récepteur sérotoninergique; Dérivé de la thiénobenzodiazépine; Psychose</FG>
<ED>Evaluation; Oral administration; Neuroleptic; Olanzapine; Controlled release form; Treatment; Schizophrenia; Psychotropic; Atypical antipsychotic; Dosage form</ED>
<EG>Dopamine antagonist; Serotonin antagonist; Dibenzodiazepine derivatives; D2 Dopamine receptor; Serotonine receptor; Thienobenzodiazepine derivatives; Psychosis</EG>
<SD>Evaluación; Vía oral; Neuroléptico; Olanzapina; Forma liberación controlada; Tratamiento; Esquizofrenia; Psicotropo; Antipsicótico atípico; Forma farmacéutica</SD>
<LO>INIST-21224.354000509415590080</LO>
<ID>11-0339142</ID>
</server>
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