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Synthesis of Sulfonamide-Bridged Glycomimetics

Identifieur interne : 001A81 ( PascalFrancis/Corpus ); précédent : 001A80; suivant : 001A82

Synthesis of Sulfonamide-Bridged Glycomimetics

Auteurs : Marie Lopez ; Laurent F. Bornaghi ; Hugues Driguez ; Sally-Ann Poulsen

Source :

RBID : Pascal:11-0339950

Descripteurs français

English descriptors

Abstract

A flexible and short synthesis of sulfonamide-bridged di-, tri-, tetra-, and octasaccharide glycomimetics was accomplished by reaction of glycosyl thioacetates with amino sugar substrates. The chemistry to incorporate the sulfonamide linker in place of a native O-glycosidic bond was broadly scoped, allowing access to head-to-head (1↔1) and head-to-tail (1→2), (1→3), (1→4), and (1→6) sulfonamide-bridged glycomimetics. The synthesis proceeds with retention of configuration at the anomeric center and is compatible with variable stereochemical arrangements and with acid- and base-labile protecting groups.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

pA  
A01 01  1    @0 0022-3263
A02 01      @0 JOCEAH
A03   1    @0 J. org. chem.
A05       @2 76
A06       @2 9
A08 01  1  ENG  @1 Synthesis of Sulfonamide-Bridged Glycomimetics
A11 01  1    @1 LOPEZ (Marie)
A11 02  1    @1 BORNAGHI (Laurent F.)
A11 03  1    @1 DRIGUEZ (Hugues)
A11 04  1    @1 POULSEN (Sally-Ann)
A14 01      @1 Eskitis Institute, Griffith University, Nathan Campus @2 Queensland, 4111 @3 AUS @Z 1 aut. @Z 2 aut. @Z 4 aut.
A14 02      @1 Centre de Recherche sur les Macromolécules Végétales, UPR-CNRS 5301, BP53 @2 38041 Grenoble @3 FRA @Z 3 aut.
A20       @1 2965-2975
A21       @1 2011
A23 01      @0 ENG
A43 01      @1 INIST @2 602 @5 354000189769030020
A44       @0 0000 @1 © 2011 INIST-CNRS. All rights reserved.
A45       @0 39 ref.
A47 01  1    @0 11-0339950
A60       @1 P
A61       @0 A
A64 01  1    @0 Journal of organic chemistry
A66 01      @0 USA
C01 01    ENG  @0 A flexible and short synthesis of sulfonamide-bridged di-, tri-, tetra-, and octasaccharide glycomimetics was accomplished by reaction of glycosyl thioacetates with amino sugar substrates. The chemistry to incorporate the sulfonamide linker in place of a native O-glycosidic bond was broadly scoped, allowing access to head-to-head (1↔1) and head-to-tail (1→2), (1→3), (1→4), and (1→6) sulfonamide-bridged glycomimetics. The synthesis proceeds with retention of configuration at the anomeric center and is compatible with variable stereochemical arrangements and with acid- and base-labile protecting groups.
C02 01  X    @0 001C03C07A
C03 01  X  FRE  @0 Synthèse chimique @5 01
C03 01  X  ENG  @0 Chemical synthesis @5 01
C03 01  X  SPA  @0 Síntesis química @5 01
C03 02  X  FRE  @0 Sulfonamide @5 02
C03 02  X  ENG  @0 Sulfonamide @5 02
C03 02  X  SPA  @0 Sulfonamida @5 02
C03 03  X  FRE  @0 Glycoside @5 04
C03 03  X  ENG  @0 Glycoside @5 04
C03 03  X  SPA  @0 Glicósido @5 04
C03 04  X  FRE  @0 Ose amine @5 05
C03 04  X  ENG  @0 Aminosugar @5 05
C03 04  X  SPA  @0 Aminoazúcar @5 05
C03 05  X  FRE  @0 Rétention configuration @5 06
C03 05  X  ENG  @0 Configuration retention @5 06
C03 05  X  SPA  @0 Retención configuración @5 06
C03 06  X  FRE  @0 Anomère @5 07
C03 06  X  ENG  @0 Anomer @5 07
C03 06  X  SPA  @0 Anómero @5 07
C03 07  X  FRE  @0 Stéréochimie @5 08
C03 07  X  ENG  @0 Stereochemistry @5 08
C03 07  X  SPA  @0 Estereoquímica @5 08
C03 08  X  FRE  @0 Groupe protecteur @5 09
C03 08  X  ENG  @0 Protecting group @5 09
C03 08  X  SPA  @0 Grupo protector @5 09
C03 09  X  FRE  @0 Oside @5 41
C03 09  X  ENG  @0 Oside @5 41
C03 09  X  SPA  @0 Osido @5 41
C03 10  X  FRE  @0 Thioacétique acide dérivé @4 INC @5 62
C03 11  X  FRE  @0 Composé glycomimétique @4 CD @5 96
C03 11  X  ENG  @0 Glycomimetic compound @4 CD @5 96
N21       @1 234

Format Inist (serveur)

NO : PASCAL 11-0339950 INIST
ET : Synthesis of Sulfonamide-Bridged Glycomimetics
AU : LOPEZ (Marie); BORNAGHI (Laurent F.); DRIGUEZ (Hugues); POULSEN (Sally-Ann)
AF : Eskitis Institute, Griffith University, Nathan Campus/Queensland, 4111/Australie (1 aut., 2 aut., 4 aut.); Centre de Recherche sur les Macromolécules Végétales, UPR-CNRS 5301, BP53/38041 Grenoble/France (3 aut.)
DT : Publication en série; Niveau analytique
SO : Journal of organic chemistry; ISSN 0022-3263; Coden JOCEAH; Etats-Unis; Da. 2011; Vol. 76; No. 9; Pp. 2965-2975; Bibl. 39 ref.
LA : Anglais
EA : A flexible and short synthesis of sulfonamide-bridged di-, tri-, tetra-, and octasaccharide glycomimetics was accomplished by reaction of glycosyl thioacetates with amino sugar substrates. The chemistry to incorporate the sulfonamide linker in place of a native O-glycosidic bond was broadly scoped, allowing access to head-to-head (1↔1) and head-to-tail (1→2), (1→3), (1→4), and (1→6) sulfonamide-bridged glycomimetics. The synthesis proceeds with retention of configuration at the anomeric center and is compatible with variable stereochemical arrangements and with acid- and base-labile protecting groups.
CC : 001C03C07A
FD : Synthèse chimique; Sulfonamide; Glycoside; Ose amine; Rétention configuration; Anomère; Stéréochimie; Groupe protecteur; Oside; Thioacétique acide dérivé; Composé glycomimétique
ED : Chemical synthesis; Sulfonamide; Glycoside; Aminosugar; Configuration retention; Anomer; Stereochemistry; Protecting group; Oside; Glycomimetic compound
SD : Síntesis química; Sulfonamida; Glicósido; Aminoazúcar; Retención configuración; Anómero; Estereoquímica; Grupo protector; Osido
LO : INIST-602.354000189769030020
ID : 11-0339950

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Pascal:11-0339950

Le document en format XML

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<div type="abstract" xml:lang="en">A flexible and short synthesis of sulfonamide-bridged di-, tri-, tetra-, and octasaccharide glycomimetics was accomplished by reaction of glycosyl thioacetates with amino sugar substrates. The chemistry to incorporate the sulfonamide linker in place of a native O-glycosidic bond was broadly scoped, allowing access to head-to-head (1↔1) and head-to-tail (1→2), (1→3), (1→4), and (1→6) sulfonamide-bridged glycomimetics. The synthesis proceeds with retention of configuration at the anomeric center and is compatible with variable stereochemical arrangements and with acid- and base-labile protecting groups.</div>
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