Improvement in Outcomes of Clinical Islet Transplantation: 1999-2010
Identifieur interne : 001796 ( PascalFrancis/Corpus ); précédent : 001795; suivant : 001797Improvement in Outcomes of Clinical Islet Transplantation: 1999-2010
Auteurs : Franca B. Barton ; Michael R. Rickels ; Rodolfo Alejandro ; Bernhard J. Hering ; Stephen Wease ; Bashoo Naziruddin ; Jose Oberholzer ; Jon S. Odorico ; Marc R. Garfinkel ; Marlon Levy ; Francois Pattou ; Thierry Berney ; Antonio Secchi ; Shari Messinger ; Peter A. Senior ; Paola Maffi ; Andrew Posselt ; Peter G. Stock ; Dixon B. Kaufman ; XUNRONG LUO ; Fouad Kandeel ; Enrico Cagliero ; Nicole A. Turgeon ; Piotr Witkowski ; Ali Naji ; Philip J. O'Connell ; Carla Greenbaum ; Yogish C. Kudva ; Kenneth L. Brayman ; Meredith J. Aull ; Christian Larsen ; Tom W. H. Kay ; Luis A. Fernandez ; Marie-Christine Vantyghem ; Melena Bellin ; A. M. James ShapiroSource :
- Diabetes care [ 0149-5992 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
OBJECTIVE-To describe trends of primary efficacy and safety outcomes of islet transplantation in type 1 diabetes recipients with severe hypoglycemia from the Collaborative Islet Transplant Registry (CITR) from 1999 to 2010. RESEARCH DESIGN AND METHODS-A total of 677 islet transplant-alone or islet-after-kidney recipients with type 1 diabetes in the CITR were analyzed for five primary efficacy outcomes and overall safety to identify any differences by early (1999-2002), mid (2003-2006), or recent (2007-2010) transplant era based on annual follow-up to 5 years. RESULTS-Insulin independence at 3 years after transplant improved from 27% in the early era (1999-2002, n = 214) to 37% in the mid (2003-2006, n = 255) and to 44% in the most recent era (2007-2010, n = 208; P = 0.006 for years-by-era; P = 0.01 for era alone). C-peptide ≥0.3 ng/mL, indicative of islet graft function, was retained longer in the most recent era (P < 0.001). Reduction of HbA1c and resolution of severe hypoglycemia exhibited enduring long-term effects. Fasting blood glucose stabilization also showed improvements in the most recent era. There were also modest reductions in the occurrence of adverse events. The islet reinfusion rate was lower: 48% by 1 year in 2007-2010 vs. 60-65% in 1999-2006 (P < 0.01). Recipients that ever achieved insulin-independence experienced longer duration of islet graft function (P < 0.001). CONCLUSIONS-The CITR shows improvement in primary efficacy and safety outcomes of islet transplantation in recipients who received transplants in 2007-2010 compared with those in 1999-2006, with fewer islet infusions and adverse events per recipient.
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
| NO : | FRANCIS 12-0301714 INIST |
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| ET : | Improvement in Outcomes of Clinical Islet Transplantation: 1999-2010 |
| AU : | BARTON (Franca B.); RICKELS (Michael R.); ALEJANDRO (Rodolfo); HERING (Bernhard J.); WEASE (Stephen); NAZIRUDDIN (Bashoo); OBERHOLZER (Jose); ODORICO (Jon S.); GARFINKEL (Marc R.); LEVY (Marlon); PATTOU (Francois); BERNEY (Thierry); SECCHI (Antonio); MESSINGER (Shari); SENIOR (Peter A.); MAFFI (Paola); POSSELT (Andrew); STOCK (Peter G.); KAUFMAN (Dixon B.); XUNRONG LUO; KANDEEL (Fouad); CAGLIERO (Enrico); TURGEON (Nicole A.); WITKOWSKI (Piotr); NAJI (Ali); O'CONNELL (Philip J.); GREENBAUM (Carla); KUDVA (Yogish C.); BRAYMAN (Kenneth L.); AULL (Meredith J.); LARSEN (Christian); KAY (Tom W. H.); FERNANDEZ (Luis A.); VANTYGHEM (Marie-Christine); BELLIN (Melena); SHAPIRO (A. M. James) |
| AF : | The EMMES Corporation/Rockville, Maryland/Etats-Unis (1 aut., 5 aut.); Department of Surgery, Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania/Philadelphia, Pennsylvania/Etats-Unis (2 aut., 25 aut.); Department of Medicine, Division of Endocrinology/Diabetes/Metabolism, University of Miami/Miami, Florida/Etats-Unis (3 aut., 14 aut.); Schultze Diabetes Institute and Department of Surgery, University of Minnesota/Minneapolis, Minnesota/Etats-Unis (4 aut., 35 aut.); Islet Processing Laboratory, Institute of Biomedical Science, Baylor University Medical Center/Dallas, Texas/Etats-Unis (6 aut.); Department of Surgery, Division of Transplant Surgery, University of Illinois at Chicago/Chicago, Illinois/Etats-Unis (7 aut.); Department of Surgery, Divsion of Transplantation, University of Wisconsin/Madison, Wisconsin/Etats-Unis (8 aut., 19 aut., 33 aut.); Department of Surgery, Division of General Surgery, Southern Illinois University/Springfield, Illinois/Etats-Unis (9 aut.); Department of Transplant Services, University of Texas, Southwest Medical School/Dallas, Texas/Etats-Unis (10 aut.); Department of General and Endocrine Surgery, Lille University/Lille/France (11 aut., 34 aut.); Department of Surgery, Division of Transplantation and Visceral Surgery, Geneva University Hospital/Geneva/Suisse (12 aut.); Department of Internal Medicine, San Raffaele University/Milan/Italie (13 aut., 16 aut.); Department of Medicine, Division of Endocrinology, University of Alberta/Edmonton, Alberta/Canada (15 aut., 36 aut.); Department of Surgery, University of California, San Francisco/San Francisco, California/Etats-Unis (17 aut., 18 aut.); Department of Medicine, Northwestern University/Chicago, Illinois/Etats-Unis (20 aut.); Division of Diabetes, Endocrinology & Metabolism, City of Hope/Duarte, California/Etats-Unis (21 aut.); MGH Diabetes Center, Massachusetts General Hospital/Boston, Massachusetts/Etats-Unis (22 aut.); Department of Surgery, Division of Transplantation, Emory University/Atlanta, Georgia/Etats-Unis (23 aut., 31 aut.); Department of Surgery, University of Chicago/Chicago, Illinois/Etats-Unis (24 aut.); Centre for Transplant and Renal Research, Westmead Hospital/Westmead, New South Wales/Australie (26 aut.); Diabetes Program, Benaroya Research Institute/Seattle, Washington/Etats-Unis (27 aut.); Department of Endocrinology, Mayo Clinic/Rochester, Minnesota/Etats-Unis (28 aut.) |
| DT : | Publication en série; Niveau analytique |
| SO : | Diabetes care; ISSN 0149-5992; Coden DICAD2; Etats-Unis; Da. 2012; Vol. 35; No. 7; Pp. 1436-1445; Bibl. 24 ref. |
| LA : | Anglais |
| EA : | OBJECTIVE-To describe trends of primary efficacy and safety outcomes of islet transplantation in type 1 diabetes recipients with severe hypoglycemia from the Collaborative Islet Transplant Registry (CITR) from 1999 to 2010. RESEARCH DESIGN AND METHODS-A total of 677 islet transplant-alone or islet-after-kidney recipients with type 1 diabetes in the CITR were analyzed for five primary efficacy outcomes and overall safety to identify any differences by early (1999-2002), mid (2003-2006), or recent (2007-2010) transplant era based on annual follow-up to 5 years. RESULTS-Insulin independence at 3 years after transplant improved from 27% in the early era (1999-2002, n = 214) to 37% in the mid (2003-2006, n = 255) and to 44% in the most recent era (2007-2010, n = 208; P = 0.006 for years-by-era; P = 0.01 for era alone). C-peptide ≥0.3 ng/mL, indicative of islet graft function, was retained longer in the most recent era (P < 0.001). Reduction of HbA1c and resolution of severe hypoglycemia exhibited enduring long-term effects. Fasting blood glucose stabilization also showed improvements in the most recent era. There were also modest reductions in the occurrence of adverse events. The islet reinfusion rate was lower: 48% by 1 year in 2007-2010 vs. 60-65% in 1999-2006 (P < 0.01). Recipients that ever achieved insulin-independence experienced longer duration of islet graft function (P < 0.001). CONCLUSIONS-The CITR shows improvement in primary efficacy and safety outcomes of islet transplantation in recipients who received transplants in 2007-2010 compared with those in 1999-2006, with fewer islet infusions and adverse events per recipient. |
| CC : | 760L |
| FD : | Homogreffe; Amélioration; Pronostic; Greffe; Evolution; Ilot Langerhans; 1999; Santé publique; Endocrinologie; Maladie métabolique; Nutrition; Homme; 2010 |
| FG : | Pancréas endocrine |
| ED : | Homograft; Improvement; Prognosis; Graft; Evolution; Langerhans islet; 1999; Public health; Endocrinology; Metabolic diseases; Nutrition; Human |
| EG : | Endocrine pancreas |
| SD : | Homoinjerto; Mejora; Pronóstico; Injerto; Evolución; Isla Langerhans; 1999; Salud pública; Endocrinología; Metabolismo patología; Nutrición; Hombre |
| LO : | INIST-18054.354000500818360080 |
| ID : | 12-0301714 |
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Francis:12-0301714Le document en format XML
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Senior</name><affiliation><inist:fA14 i1="13"><s1>Department of Medicine, Division of Endocrinology, University of Alberta</s1><s2>Edmonton, Alberta</s2><s3>CAN</s3><sZ>15 aut.</sZ><sZ>36 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Maffi, Paola" sort="Maffi, Paola" uniqKey="Maffi P" first="Paola" last="Maffi">Paola Maffi</name><affiliation><inist:fA14 i1="12"><s1>Department of Internal Medicine, San Raffaele University</s1><s2>Milan</s2><s3>ITA</s3><sZ>13 aut.</sZ><sZ>16 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Posselt, Andrew" sort="Posselt, Andrew" uniqKey="Posselt A" first="Andrew" last="Posselt">Andrew Posselt</name><affiliation><inist:fA14 i1="14"><s1>Department of Surgery, University of California, San Francisco</s1><s2>San Francisco, California</s2><s3>USA</s3><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Stock, Peter G" sort="Stock, Peter G" uniqKey="Stock P" first="Peter G." last="Stock">Peter G. Stock</name><affiliation><inist:fA14 i1="14"><s1>Department of Surgery, University of California, San Francisco</s1><s2>San Francisco, California</s2><s3>USA</s3><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Kaufman, Dixon B" sort="Kaufman, Dixon B" uniqKey="Kaufman D" first="Dixon B." last="Kaufman">Dixon B. Kaufman</name><affiliation><inist:fA14 i1="07"><s1>Department of Surgery, Divsion of Transplantation, University of Wisconsin</s1><s2>Madison, Wisconsin</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>19 aut.</sZ><sZ>33 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Xunrong Luo" sort="Xunrong Luo" uniqKey="Xunrong Luo" last="Xunrong Luo">XUNRONG LUO</name><affiliation><inist:fA14 i1="15"><s1>Department of Medicine, Northwestern University</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>20 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Kandeel, Fouad" sort="Kandeel, Fouad" uniqKey="Kandeel F" first="Fouad" last="Kandeel">Fouad Kandeel</name><affiliation><inist:fA14 i1="16"><s1>Division of Diabetes, Endocrinology & Metabolism, City of Hope</s1><s2>Duarte, California</s2><s3>USA</s3><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Cagliero, Enrico" sort="Cagliero, Enrico" uniqKey="Cagliero E" first="Enrico" last="Cagliero">Enrico Cagliero</name><affiliation><inist:fA14 i1="17"><s1>MGH Diabetes Center, Massachusetts General Hospital</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>22 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Turgeon, Nicole A" sort="Turgeon, Nicole A" uniqKey="Turgeon N" first="Nicole A." last="Turgeon">Nicole A. Turgeon</name><affiliation><inist:fA14 i1="18"><s1>Department of Surgery, Division of Transplantation, Emory University</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>23 aut.</sZ><sZ>31 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Witkowski, Piotr" sort="Witkowski, Piotr" uniqKey="Witkowski P" first="Piotr" last="Witkowski">Piotr Witkowski</name><affiliation><inist:fA14 i1="19"><s1>Department of Surgery, University of Chicago</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>24 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Naji, Ali" sort="Naji, Ali" uniqKey="Naji A" first="Ali" last="Naji">Ali Naji</name><affiliation><inist:fA14 i1="02"><s1>Department of Surgery, Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania</s1><s2>Philadelphia, Pennsylvania</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>25 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="O Connell, Philip J" sort="O Connell, Philip J" uniqKey="O Connell P" first="Philip J." last="O'Connell">Philip J. O'Connell</name><affiliation><inist:fA14 i1="20"><s1>Centre for Transplant and Renal Research, Westmead Hospital</s1><s2>Westmead, New South Wales</s2><s3>AUS</s3><sZ>26 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Greenbaum, Carla" sort="Greenbaum, Carla" uniqKey="Greenbaum C" first="Carla" last="Greenbaum">Carla Greenbaum</name><affiliation><inist:fA14 i1="21"><s1>Diabetes Program, Benaroya Research Institute</s1><s2>Seattle, Washington</s2><s3>USA</s3><sZ>27 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Kudva, Yogish C" sort="Kudva, Yogish C" uniqKey="Kudva Y" first="Yogish C." last="Kudva">Yogish C. Kudva</name><affiliation><inist:fA14 i1="22"><s1>Department of Endocrinology, Mayo Clinic</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>28 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Brayman, Kenneth L" sort="Brayman, Kenneth L" uniqKey="Brayman K" first="Kenneth L." last="Brayman">Kenneth L. Brayman</name></author><author><name sortKey="Aull, Meredith J" sort="Aull, Meredith J" uniqKey="Aull M" first="Meredith J." last="Aull">Meredith J. Aull</name></author><author><name sortKey="Larsen, Christian" sort="Larsen, Christian" uniqKey="Larsen C" first="Christian" last="Larsen">Christian Larsen</name><affiliation><inist:fA14 i1="18"><s1>Department of Surgery, Division of Transplantation, Emory University</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>23 aut.</sZ><sZ>31 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Kay, Tom W H" sort="Kay, Tom W H" uniqKey="Kay T" first="Tom W. H." last="Kay">Tom W. H. Kay</name></author><author><name sortKey="Fernandez, Luis A" sort="Fernandez, Luis A" uniqKey="Fernandez L" first="Luis A." last="Fernandez">Luis A. Fernandez</name><affiliation><inist:fA14 i1="07"><s1>Department of Surgery, Divsion of Transplantation, University of Wisconsin</s1><s2>Madison, Wisconsin</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>19 aut.</sZ><sZ>33 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Vantyghem, Marie Christine" sort="Vantyghem, Marie Christine" uniqKey="Vantyghem M" first="Marie-Christine" last="Vantyghem">Marie-Christine Vantyghem</name><affiliation><inist:fA14 i1="10"><s1>Department of General and Endocrine Surgery, Lille University</s1><s2>Lille</s2><s3>FRA</s3><sZ>11 aut.</sZ><sZ>34 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Bellin, Melena" sort="Bellin, Melena" uniqKey="Bellin M" first="Melena" last="Bellin">Melena Bellin</name><affiliation><inist:fA14 i1="04"><s1>Schultze Diabetes Institute and Department of Surgery, University of Minnesota</s1><s2>Minneapolis, Minnesota</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>35 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Shapiro, A M James" sort="Shapiro, A M James" uniqKey="Shapiro A" first="A. M. James" last="Shapiro">A. M. James Shapiro</name><affiliation><inist:fA14 i1="13"><s1>Department of Medicine, Division of Endocrinology, University of Alberta</s1><s2>Edmonton, Alberta</s2><s3>CAN</s3><sZ>15 aut.</sZ><sZ>36 aut.</sZ></inist:fA14></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0301714</idno><date when="2012">2012</date><idno type="stanalyst">FRANCIS 12-0301714 INIST</idno><idno type="RBID">Francis:12-0301714</idno><idno type="wicri:Area/PascalFrancis/Corpus">001796</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Improvement in Outcomes of Clinical Islet Transplantation: 1999-2010</title><author><name sortKey="Barton, Franca B" sort="Barton, Franca B" uniqKey="Barton F" first="Franca B." last="Barton">Franca B. Barton</name><affiliation><inist:fA14 i1="01"><s1>The EMMES Corporation</s1><s2>Rockville, Maryland</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Rickels, Michael R" sort="Rickels, Michael R" uniqKey="Rickels M" first="Michael R." last="Rickels">Michael R. Rickels</name><affiliation><inist:fA14 i1="02"><s1>Department of Surgery, Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania</s1><s2>Philadelphia, Pennsylvania</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>25 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Alejandro, Rodolfo" sort="Alejandro, Rodolfo" uniqKey="Alejandro R" first="Rodolfo" last="Alejandro">Rodolfo Alejandro</name><affiliation><inist:fA14 i1="03"><s1>Department of Medicine, Division of Endocrinology/Diabetes/Metabolism, University of Miami</s1><s2>Miami, Florida</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Hering, Bernhard J" sort="Hering, Bernhard J" uniqKey="Hering B" first="Bernhard J." last="Hering">Bernhard J. Hering</name><affiliation><inist:fA14 i1="04"><s1>Schultze Diabetes Institute and Department of Surgery, University of Minnesota</s1><s2>Minneapolis, Minnesota</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>35 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Wease, Stephen" sort="Wease, Stephen" uniqKey="Wease S" first="Stephen" last="Wease">Stephen Wease</name><affiliation><inist:fA14 i1="01"><s1>The EMMES Corporation</s1><s2>Rockville, Maryland</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Naziruddin, Bashoo" sort="Naziruddin, Bashoo" uniqKey="Naziruddin B" first="Bashoo" last="Naziruddin">Bashoo Naziruddin</name><affiliation><inist:fA14 i1="05"><s1>Islet Processing Laboratory, Institute of Biomedical Science, Baylor University Medical Center</s1><s2>Dallas, Texas</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Oberholzer, Jose" sort="Oberholzer, Jose" uniqKey="Oberholzer J" first="Jose" last="Oberholzer">Jose Oberholzer</name><affiliation><inist:fA14 i1="06"><s1>Department of Surgery, Division of Transplant Surgery, University of Illinois at Chicago</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Odorico, Jon S" sort="Odorico, Jon S" uniqKey="Odorico J" first="Jon S." last="Odorico">Jon S. Odorico</name><affiliation><inist:fA14 i1="07"><s1>Department of Surgery, Divsion of Transplantation, University of Wisconsin</s1><s2>Madison, Wisconsin</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>19 aut.</sZ><sZ>33 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Garfinkel, Marc R" sort="Garfinkel, Marc R" uniqKey="Garfinkel M" first="Marc R." last="Garfinkel">Marc R. Garfinkel</name><affiliation><inist:fA14 i1="08"><s1>Department of Surgery, Division of General Surgery, Southern Illinois University</s1><s2>Springfield, Illinois</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Levy, Marlon" sort="Levy, Marlon" uniqKey="Levy M" first="Marlon" last="Levy">Marlon Levy</name><affiliation><inist:fA14 i1="09"><s1>Department of Transplant Services, University of Texas, Southwest Medical School</s1><s2>Dallas, Texas</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Pattou, Francois" sort="Pattou, Francois" uniqKey="Pattou F" first="Francois" last="Pattou">Francois Pattou</name><affiliation><inist:fA14 i1="10"><s1>Department of General and Endocrine Surgery, Lille University</s1><s2>Lille</s2><s3>FRA</s3><sZ>11 aut.</sZ><sZ>34 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Berney, Thierry" sort="Berney, Thierry" uniqKey="Berney T" first="Thierry" last="Berney">Thierry Berney</name><affiliation><inist:fA14 i1="11"><s1>Department of Surgery, Division of Transplantation and Visceral Surgery, Geneva University Hospital</s1><s2>Geneva</s2><s3>CHE</s3><sZ>12 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Secchi, Antonio" sort="Secchi, Antonio" uniqKey="Secchi A" first="Antonio" last="Secchi">Antonio Secchi</name><affiliation><inist:fA14 i1="12"><s1>Department of Internal Medicine, San Raffaele University</s1><s2>Milan</s2><s3>ITA</s3><sZ>13 aut.</sZ><sZ>16 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Messinger, Shari" sort="Messinger, Shari" uniqKey="Messinger S" first="Shari" last="Messinger">Shari Messinger</name><affiliation><inist:fA14 i1="03"><s1>Department of Medicine, Division of Endocrinology/Diabetes/Metabolism, University of Miami</s1><s2>Miami, Florida</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Senior, Peter A" sort="Senior, Peter A" uniqKey="Senior P" first="Peter A." last="Senior">Peter A. Senior</name><affiliation><inist:fA14 i1="13"><s1>Department of Medicine, Division of Endocrinology, University of Alberta</s1><s2>Edmonton, Alberta</s2><s3>CAN</s3><sZ>15 aut.</sZ><sZ>36 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Maffi, Paola" sort="Maffi, Paola" uniqKey="Maffi P" first="Paola" last="Maffi">Paola Maffi</name><affiliation><inist:fA14 i1="12"><s1>Department of Internal Medicine, San Raffaele University</s1><s2>Milan</s2><s3>ITA</s3><sZ>13 aut.</sZ><sZ>16 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Posselt, Andrew" sort="Posselt, Andrew" uniqKey="Posselt A" first="Andrew" last="Posselt">Andrew Posselt</name><affiliation><inist:fA14 i1="14"><s1>Department of Surgery, University of California, San Francisco</s1><s2>San Francisco, California</s2><s3>USA</s3><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Stock, Peter G" sort="Stock, Peter G" uniqKey="Stock P" first="Peter G." last="Stock">Peter G. Stock</name><affiliation><inist:fA14 i1="14"><s1>Department of Surgery, University of California, San Francisco</s1><s2>San Francisco, California</s2><s3>USA</s3><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Kaufman, Dixon B" sort="Kaufman, Dixon B" uniqKey="Kaufman D" first="Dixon B." last="Kaufman">Dixon B. Kaufman</name><affiliation><inist:fA14 i1="07"><s1>Department of Surgery, Divsion of Transplantation, University of Wisconsin</s1><s2>Madison, Wisconsin</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>19 aut.</sZ><sZ>33 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Xunrong Luo" sort="Xunrong Luo" uniqKey="Xunrong Luo" last="Xunrong Luo">XUNRONG LUO</name><affiliation><inist:fA14 i1="15"><s1>Department of Medicine, Northwestern University</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>20 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Kandeel, Fouad" sort="Kandeel, Fouad" uniqKey="Kandeel F" first="Fouad" last="Kandeel">Fouad Kandeel</name><affiliation><inist:fA14 i1="16"><s1>Division of Diabetes, Endocrinology & Metabolism, City of Hope</s1><s2>Duarte, California</s2><s3>USA</s3><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Cagliero, Enrico" sort="Cagliero, Enrico" uniqKey="Cagliero E" first="Enrico" last="Cagliero">Enrico Cagliero</name><affiliation><inist:fA14 i1="17"><s1>MGH Diabetes Center, Massachusetts General Hospital</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>22 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Turgeon, Nicole A" sort="Turgeon, Nicole A" uniqKey="Turgeon N" first="Nicole A." last="Turgeon">Nicole A. Turgeon</name><affiliation><inist:fA14 i1="18"><s1>Department of Surgery, Division of Transplantation, Emory University</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>23 aut.</sZ><sZ>31 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Witkowski, Piotr" sort="Witkowski, Piotr" uniqKey="Witkowski P" first="Piotr" last="Witkowski">Piotr Witkowski</name><affiliation><inist:fA14 i1="19"><s1>Department of Surgery, University of Chicago</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>24 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Naji, Ali" sort="Naji, Ali" uniqKey="Naji A" first="Ali" last="Naji">Ali Naji</name><affiliation><inist:fA14 i1="02"><s1>Department of Surgery, Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania</s1><s2>Philadelphia, Pennsylvania</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>25 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="O Connell, Philip J" sort="O Connell, Philip J" uniqKey="O Connell P" first="Philip J." last="O'Connell">Philip J. O'Connell</name><affiliation><inist:fA14 i1="20"><s1>Centre for Transplant and Renal Research, Westmead Hospital</s1><s2>Westmead, New South Wales</s2><s3>AUS</s3><sZ>26 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Greenbaum, Carla" sort="Greenbaum, Carla" uniqKey="Greenbaum C" first="Carla" last="Greenbaum">Carla Greenbaum</name><affiliation><inist:fA14 i1="21"><s1>Diabetes Program, Benaroya Research Institute</s1><s2>Seattle, Washington</s2><s3>USA</s3><sZ>27 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Kudva, Yogish C" sort="Kudva, Yogish C" uniqKey="Kudva Y" first="Yogish C." last="Kudva">Yogish C. Kudva</name><affiliation><inist:fA14 i1="22"><s1>Department of Endocrinology, Mayo Clinic</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>28 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Brayman, Kenneth L" sort="Brayman, Kenneth L" uniqKey="Brayman K" first="Kenneth L." last="Brayman">Kenneth L. Brayman</name></author><author><name sortKey="Aull, Meredith J" sort="Aull, Meredith J" uniqKey="Aull M" first="Meredith J." last="Aull">Meredith J. Aull</name></author><author><name sortKey="Larsen, Christian" sort="Larsen, Christian" uniqKey="Larsen C" first="Christian" last="Larsen">Christian Larsen</name><affiliation><inist:fA14 i1="18"><s1>Department of Surgery, Division of Transplantation, Emory University</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>23 aut.</sZ><sZ>31 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Kay, Tom W H" sort="Kay, Tom W H" uniqKey="Kay T" first="Tom W. H." last="Kay">Tom W. H. Kay</name></author><author><name sortKey="Fernandez, Luis A" sort="Fernandez, Luis A" uniqKey="Fernandez L" first="Luis A." last="Fernandez">Luis A. Fernandez</name><affiliation><inist:fA14 i1="07"><s1>Department of Surgery, Divsion of Transplantation, University of Wisconsin</s1><s2>Madison, Wisconsin</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>19 aut.</sZ><sZ>33 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Vantyghem, Marie Christine" sort="Vantyghem, Marie Christine" uniqKey="Vantyghem M" first="Marie-Christine" last="Vantyghem">Marie-Christine Vantyghem</name><affiliation><inist:fA14 i1="10"><s1>Department of General and Endocrine Surgery, Lille University</s1><s2>Lille</s2><s3>FRA</s3><sZ>11 aut.</sZ><sZ>34 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Bellin, Melena" sort="Bellin, Melena" uniqKey="Bellin M" first="Melena" last="Bellin">Melena Bellin</name><affiliation><inist:fA14 i1="04"><s1>Schultze Diabetes Institute and Department of Surgery, University of Minnesota</s1><s2>Minneapolis, Minnesota</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>35 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Shapiro, A M James" sort="Shapiro, A M James" uniqKey="Shapiro A" first="A. M. James" last="Shapiro">A. M. James Shapiro</name><affiliation><inist:fA14 i1="13"><s1>Department of Medicine, Division of Endocrinology, University of Alberta</s1><s2>Edmonton, Alberta</s2><s3>CAN</s3><sZ>15 aut.</sZ><sZ>36 aut.</sZ></inist:fA14></affiliation></author></analytic><series><title level="j" type="main">Diabetes care</title><title level="j" type="abbreviated">Diabetes care</title><idno type="ISSN">0149-5992</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Diabetes care</title><title level="j" type="abbreviated">Diabetes care</title><idno type="ISSN">0149-5992</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1999</term><term>Endocrinology</term><term>Evolution</term><term>Graft</term><term>Homograft</term><term>Human</term><term>Improvement</term><term>Langerhans islet</term><term>Metabolic diseases</term><term>Nutrition</term><term>Prognosis</term><term>Public health</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Homogreffe</term><term>Amélioration</term><term>Pronostic</term><term>Greffe</term><term>Evolution</term><term>Ilot Langerhans</term><term>1999</term><term>Santé publique</term><term>Endocrinologie</term><term>Maladie métabolique</term><term>Nutrition</term><term>Homme</term><term>2010</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">OBJECTIVE-To describe trends of primary efficacy and safety outcomes of islet transplantation in type 1 diabetes recipients with severe hypoglycemia from the Collaborative Islet Transplant Registry (CITR) from 1999 to 2010. RESEARCH DESIGN AND METHODS-A total of 677 islet transplant-alone or islet-after-kidney recipients with type 1 diabetes in the CITR were analyzed for five primary efficacy outcomes and overall safety to identify any differences by early (1999-2002), mid (2003-2006), or recent (2007-2010) transplant era based on annual follow-up to 5 years. RESULTS-Insulin independence at 3 years after transplant improved from 27% in the early era (1999-2002, n = 214) to 37% in the mid (2003-2006, n = 255) and to 44% in the most recent era (2007-2010, n = 208; P = 0.006 for years-by-era; P = 0.01 for era alone). C-peptide ≥0.3 ng/mL, indicative of islet graft function, was retained longer in the most recent era (P < 0.001). Reduction of HbA<sub>1c</sub> and resolution of severe hypoglycemia exhibited enduring long-term effects. Fasting blood glucose stabilization also showed improvements in the most recent era. There were also modest reductions in the occurrence of adverse events. The islet reinfusion rate was lower: 48% by 1 year in 2007-2010 vs. 60-65% in 1999-2006 (P < 0.01). Recipients that ever achieved insulin-independence experienced longer duration of islet graft function (P < 0.001). CONCLUSIONS-The CITR shows improvement in primary efficacy and safety outcomes of islet transplantation in recipients who received transplants in 2007-2010 compared with those in 1999-2006, with fewer islet infusions and adverse events per recipient.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0149-5992</s0></fA01><fA02 i1="01"><s0>DICAD2</s0></fA02><fA03 i2="1"><s0>Diabetes care</s0></fA03><fA05><s2>35</s2></fA05><fA06><s2>7</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Improvement in Outcomes of Clinical Islet Transplantation: 1999-2010</s1></fA08><fA11 i1="01" i2="1"><s1>BARTON (Franca B.)</s1></fA11><fA11 i1="02" i2="1"><s1>RICKELS (Michael R.)</s1></fA11><fA11 i1="03" i2="1"><s1>ALEJANDRO (Rodolfo)</s1></fA11><fA11 i1="04" i2="1"><s1>HERING (Bernhard J.)</s1></fA11><fA11 i1="05" i2="1"><s1>WEASE (Stephen)</s1></fA11><fA11 i1="06" i2="1"><s1>NAZIRUDDIN (Bashoo)</s1></fA11><fA11 i1="07" i2="1"><s1>OBERHOLZER (Jose)</s1></fA11><fA11 i1="08" i2="1"><s1>ODORICO (Jon S.)</s1></fA11><fA11 i1="09" i2="1"><s1>GARFINKEL (Marc R.)</s1></fA11><fA11 i1="10" i2="1"><s1>LEVY (Marlon)</s1></fA11><fA11 i1="11" i2="1"><s1>PATTOU (Francois)</s1></fA11><fA11 i1="12" i2="1"><s1>BERNEY (Thierry)</s1></fA11><fA11 i1="13" i2="1"><s1>SECCHI (Antonio)</s1></fA11><fA11 i1="14" i2="1"><s1>MESSINGER (Shari)</s1></fA11><fA11 i1="15" i2="1"><s1>SENIOR (Peter A.)</s1></fA11><fA11 i1="16" i2="1"><s1>MAFFI (Paola)</s1></fA11><fA11 i1="17" i2="1"><s1>POSSELT (Andrew)</s1></fA11><fA11 i1="18" i2="1"><s1>STOCK (Peter G.)</s1></fA11><fA11 i1="19" i2="1"><s1>KAUFMAN (Dixon B.)</s1></fA11><fA11 i1="20" i2="1"><s1>XUNRONG LUO</s1></fA11><fA11 i1="21" i2="1"><s1>KANDEEL (Fouad)</s1></fA11><fA11 i1="22" i2="1"><s1>CAGLIERO (Enrico)</s1></fA11><fA11 i1="23" i2="1"><s1>TURGEON (Nicole A.)</s1></fA11><fA11 i1="24" i2="1"><s1>WITKOWSKI (Piotr)</s1></fA11><fA11 i1="25" i2="1"><s1>NAJI (Ali)</s1></fA11><fA11 i1="26" i2="1"><s1>O'CONNELL (Philip J.)</s1></fA11><fA11 i1="27" i2="1"><s1>GREENBAUM (Carla)</s1></fA11><fA11 i1="28" i2="1"><s1>KUDVA (Yogish C.)</s1></fA11><fA11 i1="29" i2="1"><s1>BRAYMAN (Kenneth L.)</s1></fA11><fA11 i1="30" i2="1"><s1>AULL (Meredith J.)</s1></fA11><fA11 i1="31" i2="1"><s1>LARSEN (Christian)</s1></fA11><fA11 i1="32" i2="1"><s1>KAY (Tom W. H.)</s1></fA11><fA11 i1="33" i2="1"><s1>FERNANDEZ (Luis A.)</s1></fA11><fA11 i1="34" i2="1"><s1>VANTYGHEM (Marie-Christine)</s1></fA11><fA11 i1="35" i2="1"><s1>BELLIN (Melena)</s1></fA11><fA11 i1="36" i2="1"><s1>SHAPIRO (A. M. James)</s1></fA11><fA14 i1="01"><s1>The EMMES Corporation</s1><s2>Rockville, Maryland</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Surgery, Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania</s1><s2>Philadelphia, Pennsylvania</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>25 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Medicine, Division of Endocrinology/Diabetes/Metabolism, University of Miami</s1><s2>Miami, Florida</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>14 aut.</sZ></fA14><fA14 i1="04"><s1>Schultze Diabetes Institute and Department of Surgery, University of Minnesota</s1><s2>Minneapolis, Minnesota</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>35 aut.</sZ></fA14><fA14 i1="05"><s1>Islet Processing Laboratory, Institute of Biomedical Science, Baylor University Medical Center</s1><s2>Dallas, Texas</s2><s3>USA</s3><sZ>6 aut.</sZ></fA14><fA14 i1="06"><s1>Department of Surgery, Division of Transplant Surgery, University of Illinois at Chicago</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>7 aut.</sZ></fA14><fA14 i1="07"><s1>Department of Surgery, Divsion of Transplantation, University of Wisconsin</s1><s2>Madison, Wisconsin</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>19 aut.</sZ><sZ>33 aut.</sZ></fA14><fA14 i1="08"><s1>Department of Surgery, Division of General Surgery, Southern Illinois University</s1><s2>Springfield, Illinois</s2><s3>USA</s3><sZ>9 aut.</sZ></fA14><fA14 i1="09"><s1>Department of Transplant Services, University of Texas, Southwest Medical School</s1><s2>Dallas, Texas</s2><s3>USA</s3><sZ>10 aut.</sZ></fA14><fA14 i1="10"><s1>Department of General and Endocrine Surgery, Lille University</s1><s2>Lille</s2><s3>FRA</s3><sZ>11 aut.</sZ><sZ>34 aut.</sZ></fA14><fA14 i1="11"><s1>Department of Surgery, Division of Transplantation and Visceral Surgery, Geneva University Hospital</s1><s2>Geneva</s2><s3>CHE</s3><sZ>12 aut.</sZ></fA14><fA14 i1="12"><s1>Department of Internal Medicine, San Raffaele University</s1><s2>Milan</s2><s3>ITA</s3><sZ>13 aut.</sZ><sZ>16 aut.</sZ></fA14><fA14 i1="13"><s1>Department of Medicine, Division of Endocrinology, University of Alberta</s1><s2>Edmonton, Alberta</s2><s3>CAN</s3><sZ>15 aut.</sZ><sZ>36 aut.</sZ></fA14><fA14 i1="14"><s1>Department of Surgery, University of California, San Francisco</s1><s2>San Francisco, California</s2><s3>USA</s3><sZ>17 aut.</sZ><sZ>18 aut.</sZ></fA14><fA14 i1="15"><s1>Department of Medicine, Northwestern University</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>20 aut.</sZ></fA14><fA14 i1="16"><s1>Division of Diabetes, Endocrinology & Metabolism, City of Hope</s1><s2>Duarte, California</s2><s3>USA</s3><sZ>21 aut.</sZ></fA14><fA14 i1="17"><s1>MGH Diabetes Center, Massachusetts General Hospital</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>22 aut.</sZ></fA14><fA14 i1="18"><s1>Department of Surgery, Division of Transplantation, Emory University</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>23 aut.</sZ><sZ>31 aut.</sZ></fA14><fA14 i1="19"><s1>Department of Surgery, University of Chicago</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>24 aut.</sZ></fA14><fA14 i1="20"><s1>Centre for Transplant and Renal Research, Westmead Hospital</s1><s2>Westmead, New South Wales</s2><s3>AUS</s3><sZ>26 aut.</sZ></fA14><fA14 i1="21"><s1>Diabetes Program, Benaroya Research Institute</s1><s2>Seattle, Washington</s2><s3>USA</s3><sZ>27 aut.</sZ></fA14><fA14 i1="22"><s1>Department of Endocrinology, Mayo Clinic</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>28 aut.</sZ></fA14><fA20><s1>1436-1445</s1></fA20><fA21><s1>2012</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>18054</s2><s5>354000500818360080</s5></fA43><fA44><s0>0000</s0><s1>© 2012 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>24 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>12-0301714</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Diabetes care</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>OBJECTIVE-To describe trends of primary efficacy and safety outcomes of islet transplantation in type 1 diabetes recipients with severe hypoglycemia from the Collaborative Islet Transplant Registry (CITR) from 1999 to 2010. RESEARCH DESIGN AND METHODS-A total of 677 islet transplant-alone or islet-after-kidney recipients with type 1 diabetes in the CITR were analyzed for five primary efficacy outcomes and overall safety to identify any differences by early (1999-2002), mid (2003-2006), or recent (2007-2010) transplant era based on annual follow-up to 5 years. RESULTS-Insulin independence at 3 years after transplant improved from 27% in the early era (1999-2002, n = 214) to 37% in the mid (2003-2006, n = 255) and to 44% in the most recent era (2007-2010, n = 208; P = 0.006 for years-by-era; P = 0.01 for era alone). C-peptide ≥0.3 ng/mL, indicative of islet graft function, was retained longer in the most recent era (P < 0.001). Reduction of HbA<sub>1c</sub> and resolution of severe hypoglycemia exhibited enduring long-term effects. Fasting blood glucose stabilization also showed improvements in the most recent era. There were also modest reductions in the occurrence of adverse events. The islet reinfusion rate was lower: 48% by 1 year in 2007-2010 vs. 60-65% in 1999-2006 (P < 0.01). Recipients that ever achieved insulin-independence experienced longer duration of islet graft function (P < 0.001). CONCLUSIONS-The CITR shows improvement in primary efficacy and safety outcomes of islet transplantation in recipients who received transplants in 2007-2010 compared with those in 1999-2006, with fewer islet infusions and adverse events per recipient.</s0></fC01><fC02 i1="01" i2="X"><s0>760L</s0><s1>XI</s1></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Homogreffe</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Homograft</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Homoinjerto</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Amélioration</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Improvement</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Mejora</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Pronostic</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Prognosis</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Pronóstico</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Greffe</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Graft</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Injerto</s0><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Evolution</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Evolution</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Evolución</s0><s5>05</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Ilot Langerhans</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Langerhans islet</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Isla Langerhans</s0><s5>06</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>1999</s0><s5>08</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>1999</s0><s5>08</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>1999</s0><s5>08</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Santé publique</s0><s5>09</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Public health</s0><s5>09</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Salud pública</s0><s5>09</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Endocrinologie</s0><s5>11</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Endocrinology</s0><s5>11</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Endocrinología</s0><s5>11</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>Maladie métabolique</s0><s5>12</s5></fC03><fC03 i1="10" i2="X" l="ENG"><s0>Metabolic diseases</s0><s5>12</s5></fC03><fC03 i1="10" i2="X" l="SPA"><s0>Metabolismo patología</s0><s5>12</s5></fC03><fC03 i1="11" i2="X" l="FRE"><s0>Nutrition</s0><s5>17</s5></fC03><fC03 i1="11" i2="X" l="ENG"><s0>Nutrition</s0><s5>17</s5></fC03><fC03 i1="11" i2="X" l="SPA"><s0>Nutrición</s0><s5>17</s5></fC03><fC03 i1="12" i2="X" l="FRE"><s0>Homme</s0><s5>25</s5></fC03><fC03 i1="12" i2="X" l="ENG"><s0>Human</s0><s5>25</s5></fC03><fC03 i1="12" i2="X" l="SPA"><s0>Hombre</s0><s5>25</s5></fC03><fC03 i1="13" i2="X" l="FRE"><s0>2010</s0><s4>INC</s4><s5>86</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Pancréas endocrine</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Endocrine pancreas</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Páncreas endocrino</s0><s5>37</s5></fC07><fN21><s1>226</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard><server><NO>FRANCIS 12-0301714 INIST</NO><ET>Improvement in Outcomes of Clinical Islet Transplantation: 1999-2010</ET><AU>BARTON (Franca B.); RICKELS (Michael R.); ALEJANDRO (Rodolfo); HERING (Bernhard J.); WEASE (Stephen); NAZIRUDDIN (Bashoo); OBERHOLZER (Jose); ODORICO (Jon S.); GARFINKEL (Marc R.); LEVY (Marlon); PATTOU (Francois); BERNEY (Thierry); SECCHI (Antonio); MESSINGER (Shari); SENIOR (Peter A.); MAFFI (Paola); POSSELT (Andrew); STOCK (Peter G.); KAUFMAN (Dixon B.); XUNRONG LUO; KANDEEL (Fouad); CAGLIERO (Enrico); TURGEON (Nicole A.); WITKOWSKI (Piotr); NAJI (Ali); O'CONNELL (Philip J.); GREENBAUM (Carla); KUDVA (Yogish C.); BRAYMAN (Kenneth L.); AULL (Meredith J.); LARSEN (Christian); KAY (Tom W. H.); FERNANDEZ (Luis A.); VANTYGHEM (Marie-Christine); BELLIN (Melena); SHAPIRO (A. M. James)</AU><AF>The EMMES Corporation/Rockville, Maryland/Etats-Unis (1 aut., 5 aut.); Department of Surgery, Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania/Philadelphia, Pennsylvania/Etats-Unis (2 aut., 25 aut.); Department of Medicine, Division of Endocrinology/Diabetes/Metabolism, University of Miami/Miami, Florida/Etats-Unis (3 aut., 14 aut.); Schultze Diabetes Institute and Department of Surgery, University of Minnesota/Minneapolis, Minnesota/Etats-Unis (4 aut., 35 aut.); Islet Processing Laboratory, Institute of Biomedical Science, Baylor University Medical Center/Dallas, Texas/Etats-Unis (6 aut.); Department of Surgery, Division of Transplant Surgery, University of Illinois at Chicago/Chicago, Illinois/Etats-Unis (7 aut.); Department of Surgery, Divsion of Transplantation, University of Wisconsin/Madison, Wisconsin/Etats-Unis (8 aut., 19 aut., 33 aut.); Department of Surgery, Division of General Surgery, Southern Illinois University/Springfield, Illinois/Etats-Unis (9 aut.); Department of Transplant Services, University of Texas, Southwest Medical School/Dallas, Texas/Etats-Unis (10 aut.); Department of General and Endocrine Surgery, Lille University/Lille/France (11 aut., 34 aut.); Department of Surgery, Division of Transplantation and Visceral Surgery, Geneva University Hospital/Geneva/Suisse (12 aut.); Department of Internal Medicine, San Raffaele University/Milan/Italie (13 aut., 16 aut.); Department of Medicine, Division of Endocrinology, University of Alberta/Edmonton, Alberta/Canada (15 aut., 36 aut.); Department of Surgery, University of California, San Francisco/San Francisco, California/Etats-Unis (17 aut., 18 aut.); Department of Medicine, Northwestern University/Chicago, Illinois/Etats-Unis (20 aut.); Division of Diabetes, Endocrinology & Metabolism, City of Hope/Duarte, California/Etats-Unis (21 aut.); MGH Diabetes Center, Massachusetts General Hospital/Boston, Massachusetts/Etats-Unis (22 aut.); Department of Surgery, Division of Transplantation, Emory University/Atlanta, Georgia/Etats-Unis (23 aut., 31 aut.); Department of Surgery, University of Chicago/Chicago, Illinois/Etats-Unis (24 aut.); Centre for Transplant and Renal Research, Westmead Hospital/Westmead, New South Wales/Australie (26 aut.); Diabetes Program, Benaroya Research Institute/Seattle, Washington/Etats-Unis (27 aut.); Department of Endocrinology, Mayo Clinic/Rochester, Minnesota/Etats-Unis (28 aut.)</AF><DT>Publication en série; Niveau analytique</DT><SO>Diabetes care; ISSN 0149-5992; Coden DICAD2; Etats-Unis; Da. 2012; Vol. 35; No. 7; Pp. 1436-1445; Bibl. 24 ref.</SO><LA>Anglais</LA><EA>OBJECTIVE-To describe trends of primary efficacy and safety outcomes of islet transplantation in type 1 diabetes recipients with severe hypoglycemia from the Collaborative Islet Transplant Registry (CITR) from 1999 to 2010. RESEARCH DESIGN AND METHODS-A total of 677 islet transplant-alone or islet-after-kidney recipients with type 1 diabetes in the CITR were analyzed for five primary efficacy outcomes and overall safety to identify any differences by early (1999-2002), mid (2003-2006), or recent (2007-2010) transplant era based on annual follow-up to 5 years. RESULTS-Insulin independence at 3 years after transplant improved from 27% in the early era (1999-2002, n = 214) to 37% in the mid (2003-2006, n = 255) and to 44% in the most recent era (2007-2010, n = 208; P = 0.006 for years-by-era; P = 0.01 for era alone). C-peptide ≥0.3 ng/mL, indicative of islet graft function, was retained longer in the most recent era (P < 0.001). Reduction of HbA<sub>1c</sub> and resolution of severe hypoglycemia exhibited enduring long-term effects. Fasting blood glucose stabilization also showed improvements in the most recent era. There were also modest reductions in the occurrence of adverse events. The islet reinfusion rate was lower: 48% by 1 year in 2007-2010 vs. 60-65% in 1999-2006 (P < 0.01). Recipients that ever achieved insulin-independence experienced longer duration of islet graft function (P < 0.001). CONCLUSIONS-The CITR shows improvement in primary efficacy and safety outcomes of islet transplantation in recipients who received transplants in 2007-2010 compared with those in 1999-2006, with fewer islet infusions and adverse events per recipient.</EA><CC>760L</CC><FD>Homogreffe; Amélioration; Pronostic; Greffe; Evolution; Ilot Langerhans; 1999; Santé publique; Endocrinologie; Maladie métabolique; Nutrition; Homme; 2010</FD><FG>Pancréas endocrine</FG><ED>Homograft; Improvement; Prognosis; Graft; Evolution; Langerhans islet; 1999; Public health; Endocrinology; Metabolic diseases; Nutrition; Human</ED><EG>Endocrine pancreas</EG><SD>Homoinjerto; Mejora; Pronóstico; Injerto; Evolución; Isla Langerhans; 1999; Salud pública; Endocrinología; Metabolismo patología; Nutrición; Hombre</SD><LO>INIST-18054.354000500818360080</LO><ID>12-0301714</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
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