Vandetanib in Patients With Locally Advanced or Metastatic Medullary Thyroid Cancer: A Randomized, Double-Blind Phase III Trial
Identifieur interne : 001584 ( PascalFrancis/Corpus ); précédent : 001583; suivant : 001585Vandetanib in Patients With Locally Advanced or Metastatic Medullary Thyroid Cancer: A Randomized, Double-Blind Phase III Trial
Auteurs : Samuel A. Jr Wells ; Bruce G. Robinson ; Robert F. Gagel ; Henning Dralle ; James A. Fagin ; Massimo Santoro ; Eric Baudin ; Rossella Elisei ; Barbara Jarzab ; James R. Vasselli ; Jessica Read ; Peter Langmuir ; Anderson J. Ryan ; Martin J. SchlumbergerSource :
- Journal of clinical oncology [ 0732-183X ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Purpose There is no effective therapy for patients with advanced medullary thyroid carcinoma (MTC). Vandetanib, a once-daily oral inhibitor of RET kinase, vascular endothelial growth factor receptor, and epidermal growth factor receptor signaling, has previously shown antitumor activity in a phase II study of patients with advanced hereditary MTC. Patients and Methods Patients with advanced MTC were randomly assigned in a 2:1 ratio to receive vandetanib 300 mg/d or placebo. On objective disease progression, patients could elect to receive open-label vandetanib. The primary end point was progression-free survival (PFS), determined by independent central Response Evaluation Criteria in Solid Tumors (RECIST) assessments. Results Between December 2006 and November 2007, 331 patients (mean age, 52 years; 90% sporadic; 95% metastatic) were randomly assigned to receive vandetanib (231) or placebo (100). At data cutoff (July 2009; median follow-up, 24 months), 37% of patients had progressed and 15% had died. The study met its primary objective of PFS prolongation with vandetanib versus placebo (hazard ratio [HR], 0.46; 95% CI, 0.31 to 0.69; P < .001). Statistically significant advantages for vandetanib were also seen for objective response rate (P < .001), disease control rate (P = .001), and biochemical response (P < .001). Overall survival data were immature at data cutoff (HR, 0.89; 95% CI, 0.48 to 1.65). A final survival analysis will take place when 50% of the patients have died. Common adverse events (any grade) occurred more frequently with vandetanib compared with placebo, including diarrhea (56% v 26%), rash (45% v 11%), nausea (33% v 16%), hypertension (32% v 5%), and headache (26% v 9%). Conclusion Vandetanib demonstrated therapeutic efficacy in a phase III trial of patients with advanced MTC.
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Format Inist (serveur)
NO : | PASCAL 12-0103079 INIST |
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ET : | Vandetanib in Patients With Locally Advanced or Metastatic Medullary Thyroid Cancer: A Randomized, Double-Blind Phase III Trial |
AU : | WELLS (Samuel A. JR); ROBINSON (Bruce G.); GAGEL (Robert F.); DRALLE (Henning); FAGIN (James A.); SANTORO (Massimo); BAUDIN (Eric); ELISEI (Rossella); JARZAB (Barbara); VASSELLI (James R.); READ (Jessica); LANGMUIR (Peter); RYAN (Anderson J.); SCHLUMBERGER (Martin J.) |
AF : | National Cancer Institute, National Institutes of Health/Bethesda, MD/Etats-Unis (1 aut.); Robinson, Kolling Institute of Medical Research, University of Sydney/Sydney/Australie (2 aut.); University of Texas MD Anderson Cancer Center/Houston, TX/Etats-Unis (3 aut.); Martin Luther University Halle-Wittenberg/Halle/Allemagne (4 aut.); Memorial Sloan-Kettering Cancer Center/New York, NY/Etats-Unis (5 aut.); Universita' di Napoli Federico II/Naples/Italie (6 aut.); Institut Gustave Roussy/Villejuif/France (7 aut., 14 aut.); University of Pisa/Pisa/Italie (8 aut.); Maria Sklodowska-Curie Memorial Cancer Center/Gliwice/Pologne (9 aut.); AstraZeneca/Wilmington, DE/Royaume-Uni (10 aut., 12 aut.); AstraZeneca/Macclesfield/Royaume-Uni (11 aut.); University of Oxford/Oxford/Royaume-Uni (13 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Journal of clinical oncology; ISSN 0732-183X; Etats-Unis; Da. 2012; Vol. 30; No. 2; Pp. 134-141; Bibl. 29 ref. |
LA : | Anglais |
EA : | Purpose There is no effective therapy for patients with advanced medullary thyroid carcinoma (MTC). Vandetanib, a once-daily oral inhibitor of RET kinase, vascular endothelial growth factor receptor, and epidermal growth factor receptor signaling, has previously shown antitumor activity in a phase II study of patients with advanced hereditary MTC. Patients and Methods Patients with advanced MTC were randomly assigned in a 2:1 ratio to receive vandetanib 300 mg/d or placebo. On objective disease progression, patients could elect to receive open-label vandetanib. The primary end point was progression-free survival (PFS), determined by independent central Response Evaluation Criteria in Solid Tumors (RECIST) assessments. Results Between December 2006 and November 2007, 331 patients (mean age, 52 years; 90% sporadic; 95% metastatic) were randomly assigned to receive vandetanib (231) or placebo (100). At data cutoff (July 2009; median follow-up, 24 months), 37% of patients had progressed and 15% had died. The study met its primary objective of PFS prolongation with vandetanib versus placebo (hazard ratio [HR], 0.46; 95% CI, 0.31 to 0.69; P < .001). Statistically significant advantages for vandetanib were also seen for objective response rate (P < .001), disease control rate (P = .001), and biochemical response (P < .001). Overall survival data were immature at data cutoff (HR, 0.89; 95% CI, 0.48 to 1.65). A final survival analysis will take place when 50% of the patients have died. Common adverse events (any grade) occurred more frequently with vandetanib compared with placebo, including diarrhea (56% v 26%), rash (45% v 11%), nausea (33% v 16%), hypertension (32% v 5%), and headache (26% v 9%). Conclusion Vandetanib demonstrated therapeutic efficacy in a phase III trial of patients with advanced MTC. |
CC : | 002B04; 002B21C02 |
FD : | Vandétanib; Homme; Stade avancé; Métastase; Essai clinique; Randomisation; Cancer de la thyroïde; Cancérologie; Essai clinique phase III; Chimiothérapie; Anticancéreux; Antiangiogénique; Stade localement avancé |
FG : | Traitement; Inhibiteur enzyme; Protein-tyrosine kinase; Transferases; Enzyme; Inhibiteur de la tyrosine kinase; Inhibiteur multikinase; Tumeur maligne; Cancer; Endocrinopathie; Pathologie de la thyroïde |
ED : | Vandetanib; Human; Advanced stage; Metastasis; Clinical trial; Randomization; Thyroid cancer; Cancerology; Phase III trial; Chemotherapy; Antineoplastic agent; Antiangiogenic agent; Locally advanced stage |
EG : | Treatment; Enzyme inhibitor; Protein-tyrosine kinase; Transferases; Enzyme; Tyrosine kinase inhibitor; Multikinase inhibitor; Malignant tumor; Cancer; Endocrinopathy; Thyroid diseases |
SD : | Vandetanib; Hombre; Estadio avanzado; Metástasis; Ensayo clínico; Aleatorización; Cáncer de la tiroides; Cancerología; Ensayo clínico fase III; Quimioterapia; Anticanceroso; Antiangiogenico; Estadio localmente avanzado |
LO : | INIST-20094.354000508873560070 |
ID : | 12-0103079 |
Links to Exploration step
Pascal:12-0103079Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Vandetanib in Patients With Locally Advanced or Metastatic Medullary Thyroid Cancer: A Randomized, Double-Blind Phase III Trial</title>
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<author><name sortKey="Gagel, Robert F" sort="Gagel, Robert F" uniqKey="Gagel R" first="Robert F." last="Gagel">Robert F. Gagel</name>
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<author><name sortKey="Baudin, Eric" sort="Baudin, Eric" uniqKey="Baudin E" first="Eric" last="Baudin">Eric Baudin</name>
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<author><name sortKey="Ryan, Anderson J" sort="Ryan, Anderson J" uniqKey="Ryan A" first="Anderson J." last="Ryan">Anderson J. Ryan</name>
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<author><name sortKey="Schlumberger, Martin J" sort="Schlumberger, Martin J" uniqKey="Schlumberger M" first="Martin J." last="Schlumberger">Martin J. Schlumberger</name>
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<series><title level="j" type="main">Journal of clinical oncology</title>
<title level="j" type="abbreviated">J. clin. oncol.</title>
<idno type="ISSN">0732-183X</idno>
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<seriesStmt><title level="j" type="main">Journal of clinical oncology</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Advanced stage</term>
<term>Antiangiogenic agent</term>
<term>Antineoplastic agent</term>
<term>Cancerology</term>
<term>Chemotherapy</term>
<term>Clinical trial</term>
<term>Human</term>
<term>Locally advanced stage</term>
<term>Metastasis</term>
<term>Phase III trial</term>
<term>Randomization</term>
<term>Thyroid cancer</term>
<term>Vandetanib</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Vandétanib</term>
<term>Homme</term>
<term>Stade avancé</term>
<term>Métastase</term>
<term>Essai clinique</term>
<term>Randomisation</term>
<term>Cancer de la thyroïde</term>
<term>Cancérologie</term>
<term>Essai clinique phase III</term>
<term>Chimiothérapie</term>
<term>Anticancéreux</term>
<term>Antiangiogénique</term>
<term>Stade localement avancé</term>
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<front><div type="abstract" xml:lang="en">Purpose There is no effective therapy for patients with advanced medullary thyroid carcinoma (MTC). Vandetanib, a once-daily oral inhibitor of RET kinase, vascular endothelial growth factor receptor, and epidermal growth factor receptor signaling, has previously shown antitumor activity in a phase II study of patients with advanced hereditary MTC. Patients and Methods Patients with advanced MTC were randomly assigned in a 2:1 ratio to receive vandetanib 300 mg/d or placebo. On objective disease progression, patients could elect to receive open-label vandetanib. The primary end point was progression-free survival (PFS), determined by independent central Response Evaluation Criteria in Solid Tumors (RECIST) assessments. Results Between December 2006 and November 2007, 331 patients (mean age, 52 years; 90% sporadic; 95% metastatic) were randomly assigned to receive vandetanib (231) or placebo (100). At data cutoff (July 2009; median follow-up, 24 months), 37% of patients had progressed and 15% had died. The study met its primary objective of PFS prolongation with vandetanib versus placebo (hazard ratio [HR], 0.46; 95% CI, 0.31 to 0.69; P < .001). Statistically significant advantages for vandetanib were also seen for objective response rate (P < .001), disease control rate (P = .001), and biochemical response (P < .001). Overall survival data were immature at data cutoff (HR, 0.89; 95% CI, 0.48 to 1.65). A final survival analysis will take place when 50% of the patients have died. Common adverse events (any grade) occurred more frequently with vandetanib compared with placebo, including diarrhea (56% v 26%), rash (45% v 11%), nausea (33% v 16%), hypertension (32% v 5%), and headache (26% v 9%). Conclusion Vandetanib demonstrated therapeutic efficacy in a phase III trial of patients with advanced MTC.</div>
</front>
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<fA11 i1="01" i2="1"><s1>WELLS (Samuel A. JR)</s1>
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<fA11 i1="02" i2="1"><s1>ROBINSON (Bruce G.)</s1>
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<fA11 i1="03" i2="1"><s1>GAGEL (Robert F.)</s1>
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<fA11 i1="09" i2="1"><s1>JARZAB (Barbara)</s1>
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<fA11 i1="12" i2="1"><s1>LANGMUIR (Peter)</s1>
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<fA11 i1="14" i2="1"><s1>SCHLUMBERGER (Martin J.)</s1>
</fA11>
<fA14 i1="01"><s1>National Cancer Institute, National Institutes of Health</s1>
<s2>Bethesda, MD</s2>
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<sZ>1 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Robinson, Kolling Institute of Medical Research, University of Sydney</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>2 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>University of Texas MD Anderson Cancer Center</s1>
<s2>Houston, TX</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Martin Luther University Halle-Wittenberg</s1>
<s2>Halle</s2>
<s3>DEU</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Memorial Sloan-Kettering Cancer Center</s1>
<s2>New York, NY</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Universita' di Napoli Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>Institut Gustave Roussy</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
<sZ>14 aut.</sZ>
</fA14>
<fA14 i1="08"><s1>University of Pisa</s1>
<s2>Pisa</s2>
<s3>ITA</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="09"><s1>Maria Sklodowska-Curie Memorial Cancer Center</s1>
<s2>Gliwice</s2>
<s3>POL</s3>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="10"><s1>AstraZeneca</s1>
<s2>Wilmington, DE</s2>
<s3>GBR</s3>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</fA14>
<fA14 i1="11"><s1>AstraZeneca</s1>
<s2>Macclesfield</s2>
<s3>GBR</s3>
<sZ>11 aut.</sZ>
</fA14>
<fA14 i1="12"><s1>University of Oxford</s1>
<s2>Oxford</s2>
<s3>GBR</s3>
<sZ>13 aut.</sZ>
</fA14>
<fA20><s1>134-141</s1>
</fA20>
<fA21><s1>2012</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>20094</s2>
<s5>354000508873560070</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2012 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>29 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>12-0103079</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Journal of clinical oncology</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Purpose There is no effective therapy for patients with advanced medullary thyroid carcinoma (MTC). Vandetanib, a once-daily oral inhibitor of RET kinase, vascular endothelial growth factor receptor, and epidermal growth factor receptor signaling, has previously shown antitumor activity in a phase II study of patients with advanced hereditary MTC. Patients and Methods Patients with advanced MTC were randomly assigned in a 2:1 ratio to receive vandetanib 300 mg/d or placebo. On objective disease progression, patients could elect to receive open-label vandetanib. The primary end point was progression-free survival (PFS), determined by independent central Response Evaluation Criteria in Solid Tumors (RECIST) assessments. Results Between December 2006 and November 2007, 331 patients (mean age, 52 years; 90% sporadic; 95% metastatic) were randomly assigned to receive vandetanib (231) or placebo (100). At data cutoff (July 2009; median follow-up, 24 months), 37% of patients had progressed and 15% had died. The study met its primary objective of PFS prolongation with vandetanib versus placebo (hazard ratio [HR], 0.46; 95% CI, 0.31 to 0.69; P < .001). Statistically significant advantages for vandetanib were also seen for objective response rate (P < .001), disease control rate (P = .001), and biochemical response (P < .001). Overall survival data were immature at data cutoff (HR, 0.89; 95% CI, 0.48 to 1.65). A final survival analysis will take place when 50% of the patients have died. Common adverse events (any grade) occurred more frequently with vandetanib compared with placebo, including diarrhea (56% v 26%), rash (45% v 11%), nausea (33% v 16%), hypertension (32% v 5%), and headache (26% v 9%). Conclusion Vandetanib demonstrated therapeutic efficacy in a phase III trial of patients with advanced MTC.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B04</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B21C02</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Vandétanib</s0>
<s2>FR</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Vandetanib</s0>
<s2>FR</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Vandetanib</s0>
<s2>FR</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Homme</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Human</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Hombre</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Stade avancé</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Advanced stage</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Estadio avanzado</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Métastase</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Metastasis</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Metástasis</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Essai clinique</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Clinical trial</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Ensayo clínico</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Randomisation</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Randomization</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Aleatorización</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Cancer de la thyroïde</s0>
<s2>NM</s2>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Thyroid cancer</s0>
<s2>NM</s2>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Cáncer de la tiroides</s0>
<s2>NM</s2>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Cancérologie</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Cancerology</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Cancerología</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Essai clinique phase III</s0>
<s5>10</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Phase III trial</s0>
<s5>10</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Ensayo clínico fase III</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Chimiothérapie</s0>
<s5>13</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Chemotherapy</s0>
<s5>13</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Quimioterapia</s0>
<s5>13</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Anticancéreux</s0>
<s5>25</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Antineoplastic agent</s0>
<s5>25</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Anticanceroso</s0>
<s5>25</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Antiangiogénique</s0>
<s2>FR</s2>
<s5>26</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Antiangiogenic agent</s0>
<s2>FR</s2>
<s5>26</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Antiangiogenico</s0>
<s2>FR</s2>
<s5>26</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Stade localement avancé</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Locally advanced stage</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Estadio localmente avanzado</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Traitement</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Treatment</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Tratamiento</s0>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Inhibiteur enzyme</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Enzyme inhibitor</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Inhibidor enzima</s0>
<s5>37</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Protein-tyrosine kinase</s0>
<s2>FE</s2>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Protein-tyrosine kinase</s0>
<s2>FE</s2>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Protein-tyrosine kinase</s0>
<s2>FE</s2>
<s5>38</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Transferases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Transferases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Transferases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Enzima</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Inhibiteur de la tyrosine kinase</s0>
<s5>39</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Tyrosine kinase inhibitor</s0>
<s5>39</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Inhibidor tyrosine kinase</s0>
<s5>39</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Inhibiteur multikinase</s0>
<s5>40</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Multikinase inhibitor</s0>
<s5>40</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>inhibidor multicinasa</s0>
<s5>40</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Tumeur maligne</s0>
<s2>NM</s2>
<s5>41</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Malignant tumor</s0>
<s2>NM</s2>
<s5>41</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Tumor maligno</s0>
<s2>NM</s2>
<s5>41</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Cancer</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Cancer</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Cáncer</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="10" i2="X" l="FRE"><s0>Endocrinopathie</s0>
<s5>42</s5>
</fC07>
<fC07 i1="10" i2="X" l="ENG"><s0>Endocrinopathy</s0>
<s5>42</s5>
</fC07>
<fC07 i1="10" i2="X" l="SPA"><s0>Endocrinopatía</s0>
<s5>42</s5>
</fC07>
<fC07 i1="11" i2="X" l="FRE"><s0>Pathologie de la thyroïde</s0>
<s5>43</s5>
</fC07>
<fC07 i1="11" i2="X" l="ENG"><s0>Thyroid diseases</s0>
<s5>43</s5>
</fC07>
<fC07 i1="11" i2="X" l="SPA"><s0>Tiroides patología</s0>
<s5>43</s5>
</fC07>
<fN21><s1>079</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 12-0103079 INIST</NO>
<ET>Vandetanib in Patients With Locally Advanced or Metastatic Medullary Thyroid Cancer: A Randomized, Double-Blind Phase III Trial</ET>
<AU>WELLS (Samuel A. JR); ROBINSON (Bruce G.); GAGEL (Robert F.); DRALLE (Henning); FAGIN (James A.); SANTORO (Massimo); BAUDIN (Eric); ELISEI (Rossella); JARZAB (Barbara); VASSELLI (James R.); READ (Jessica); LANGMUIR (Peter); RYAN (Anderson J.); SCHLUMBERGER (Martin J.)</AU>
<AF>National Cancer Institute, National Institutes of Health/Bethesda, MD/Etats-Unis (1 aut.); Robinson, Kolling Institute of Medical Research, University of Sydney/Sydney/Australie (2 aut.); University of Texas MD Anderson Cancer Center/Houston, TX/Etats-Unis (3 aut.); Martin Luther University Halle-Wittenberg/Halle/Allemagne (4 aut.); Memorial Sloan-Kettering Cancer Center/New York, NY/Etats-Unis (5 aut.); Universita' di Napoli Federico II/Naples/Italie (6 aut.); Institut Gustave Roussy/Villejuif/France (7 aut., 14 aut.); University of Pisa/Pisa/Italie (8 aut.); Maria Sklodowska-Curie Memorial Cancer Center/Gliwice/Pologne (9 aut.); AstraZeneca/Wilmington, DE/Royaume-Uni (10 aut., 12 aut.); AstraZeneca/Macclesfield/Royaume-Uni (11 aut.); University of Oxford/Oxford/Royaume-Uni (13 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Journal of clinical oncology; ISSN 0732-183X; Etats-Unis; Da. 2012; Vol. 30; No. 2; Pp. 134-141; Bibl. 29 ref.</SO>
<LA>Anglais</LA>
<EA>Purpose There is no effective therapy for patients with advanced medullary thyroid carcinoma (MTC). Vandetanib, a once-daily oral inhibitor of RET kinase, vascular endothelial growth factor receptor, and epidermal growth factor receptor signaling, has previously shown antitumor activity in a phase II study of patients with advanced hereditary MTC. Patients and Methods Patients with advanced MTC were randomly assigned in a 2:1 ratio to receive vandetanib 300 mg/d or placebo. On objective disease progression, patients could elect to receive open-label vandetanib. The primary end point was progression-free survival (PFS), determined by independent central Response Evaluation Criteria in Solid Tumors (RECIST) assessments. Results Between December 2006 and November 2007, 331 patients (mean age, 52 years; 90% sporadic; 95% metastatic) were randomly assigned to receive vandetanib (231) or placebo (100). At data cutoff (July 2009; median follow-up, 24 months), 37% of patients had progressed and 15% had died. The study met its primary objective of PFS prolongation with vandetanib versus placebo (hazard ratio [HR], 0.46; 95% CI, 0.31 to 0.69; P < .001). Statistically significant advantages for vandetanib were also seen for objective response rate (P < .001), disease control rate (P = .001), and biochemical response (P < .001). Overall survival data were immature at data cutoff (HR, 0.89; 95% CI, 0.48 to 1.65). A final survival analysis will take place when 50% of the patients have died. Common adverse events (any grade) occurred more frequently with vandetanib compared with placebo, including diarrhea (56% v 26%), rash (45% v 11%), nausea (33% v 16%), hypertension (32% v 5%), and headache (26% v 9%). Conclusion Vandetanib demonstrated therapeutic efficacy in a phase III trial of patients with advanced MTC.</EA>
<CC>002B04; 002B21C02</CC>
<FD>Vandétanib; Homme; Stade avancé; Métastase; Essai clinique; Randomisation; Cancer de la thyroïde; Cancérologie; Essai clinique phase III; Chimiothérapie; Anticancéreux; Antiangiogénique; Stade localement avancé</FD>
<FG>Traitement; Inhibiteur enzyme; Protein-tyrosine kinase; Transferases; Enzyme; Inhibiteur de la tyrosine kinase; Inhibiteur multikinase; Tumeur maligne; Cancer; Endocrinopathie; Pathologie de la thyroïde</FG>
<ED>Vandetanib; Human; Advanced stage; Metastasis; Clinical trial; Randomization; Thyroid cancer; Cancerology; Phase III trial; Chemotherapy; Antineoplastic agent; Antiangiogenic agent; Locally advanced stage</ED>
<EG>Treatment; Enzyme inhibitor; Protein-tyrosine kinase; Transferases; Enzyme; Tyrosine kinase inhibitor; Multikinase inhibitor; Malignant tumor; Cancer; Endocrinopathy; Thyroid diseases</EG>
<SD>Vandetanib; Hombre; Estadio avanzado; Metástasis; Ensayo clínico; Aleatorización; Cáncer de la tiroides; Cancerología; Ensayo clínico fase III; Quimioterapia; Anticanceroso; Antiangiogenico; Estadio localmente avanzado</SD>
<LO>INIST-20094.354000508873560070</LO>
<ID>12-0103079</ID>
</server>
</inist>
</record>
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