Previous Fractures at Multiple Sites Increase the Risk for Subsequent Fractures: The Global Longitudinal Study of Osteoporosis in Women
Identifieur interne : 001503 ( PascalFrancis/Corpus ); précédent : 001502; suivant : 001504Previous Fractures at Multiple Sites Increase the Risk for Subsequent Fractures: The Global Longitudinal Study of Osteoporosis in Women
Auteurs : Stephen Gehlbach ; Kenneth G. Saag ; Jonathan D. Adachi ; Fred H. Hooven ; Julie Flahive ; Steven Boonen ; Roland D. Chapurlat ; Juliet E. Compston ; Cyrus Cooper ; Adolfo Diez-Perez ; Susan L. Greenspan ; Andrea Z. Lacroix ; J. Coen Netelenbos ; Johannes Pfeilschifter ; Maurizio Rossini ; Christian Roux ; Philip N. Sambrook ; Stuart Silverman ; Ethel S. Siris ; Nelson B. Watts ; Robert LindsaySource :
- Journal of bone and mineral research : (Print) [ 0884-0431 ] ; 2012.
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English descriptors
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Abstract
Previous fractures of the hip, spine, or wrist are well-recognized predictors of future fracture, but the role of other fracture sites is less clear. We sought to assess the relationship between prior fracture at 10 skeletal locations and incident fracture. The Global Longitudinal Study of Osteoporosis in Women (GLOW) is an observational cohort study being conducted in 17 physician practices in 10 countries. Women aged ≥55 years answered questionnaires at baseline and at 1 and/or 2 years (fractures in previous year). Of 60,393 women enrolled, follow-up data were available for 51,762. Of these, 17.6%, 4.0%, and 1.6% had suffered 1, 2, or >3 fractures, respectively, since age 45 years. During the first 2 years of follow-up, 3149 women suffered 3683 incident fractures. Compared with women with no previous fractures, women with 1, 2, or ≥3 prior fractures were 1.8-, 3.0-, and 4.8-fold more likely to have any incident fracture; those with >3 prior fractures were 9.1-fold more likely to sustain a new vertebral fracture. Nine of 10 prior fracture locations were associated with an incident fracture. The strongest predictors of incident spine and hip fractures were prior spine fracture (hazard ratio [HR] = 7.3) and hip (HR = 3.5). Prior rib fractures were associated with a 2.3-fold risk of subsequent vertebral fracture, and previous upper leg fracture predicted a 2.2-fold increased risk of hip fracture. Women with a history of ankle fracture were at 1.8-fold risk of future fracture of a weight-bearing bone. Our findings suggest that a broad range of prior fracture sites are associated with an increased risk of incident fractures, with important implications for clinical assessments and risk model development.
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Format Inist (serveur)
| NO : | PASCAL 12-0152233 INIST |
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| ET : | Previous Fractures at Multiple Sites Increase the Risk for Subsequent Fractures: The Global Longitudinal Study of Osteoporosis in Women |
| AU : | GEHLBACH (Stephen); SAAG (Kenneth G.); ADACHI (Jonathan D.); HOOVEN (Fred H.); FLAHIVE (Julie); BOONEN (Steven); CHAPURLAT (Roland D.); COMPSTON (Juliet E.); COOPER (Cyrus); DIEZ-PEREZ (Adolfo); GREENSPAN (Susan L.); LACROIX (Andrea Z.); NETELENBOS (J. Coen); PFEILSCHIFTER (Johannes); ROSSINI (Maurizio); ROUX (Christian); SAMBROOK (Philip N.); SILVERMAN (Stuart); SIRIS (Ethel S.); WATTS (Nelson B.); LINDSAY (Robert) |
| AF : | Center for Outcomes Research, University of Massachusetts Medical School/Worcester, MA/Etats-Unis (1 aut., 4 aut., 5 aut.); Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham/Birmingham, AL/Etats-Unis (2 aut.); St. Joseph's Healthcare, McMaster University/Hamilton, ON/Canada (3 aut.); Universiteit Leuven/Leuven/Belgique (6 aut.); Division of Rheumatology, INSERM UMR 1033, Université de Lyon, Hospices Civils de Lyon, Hôpital E Herriot/Lyon/France (7 aut.); Cambridge University Hospitals NHS Foundation Trust/Cambridge/Royaume-Uni (8 aut.); MRC Lifecourse Epidemiology Unit, University of Southampton/Southampton/Royaume-Uni (9 aut.); Hospital del Mar-IMIM-Autonomous University of Barcelona/Barcelona/Espagne (10 aut.); RETICEF, ISCIII/Madrid/Espagne (10 aut.); University of Pittsburgh/Pittsburgh, PA/Etats-Unis (11 aut.); Fred Hutchinson Cancer Research Center/Seattle, WA/Etats-Unis (12 aut.); Department of Endocrinology, VU University Medical Center/Amsterdam/Pays-Bas (13 aut.); Department of Internal Medicine III, Alfried Krupp Krankenhaus/Essen/Allemagne (14 aut.); Department of Rheumatology, University of Verona, Ospedale/Verona, Valeggio/Italie (15 aut.); Paris Descartes University, Cochin Hospital/Paris/France (16 aut.); University of Sydney-Royal North Shore Hospital, St. Leonards/Sydney, NSW/Australie (17 aut.); Department of Rheumatology, Cedars-Sinai Medical Center/Los Angeles, CA/Etats-Unis (18 aut.); Columbia University Medical Center/New York, NY/Etats-Unis (19 aut.); Bone Health and Osteoporosis Center, University of Cincinnati/Cincinnati, OH/Etats-Unis (20 aut.); Regional Bone Center, Helen Hayes Hospital/West Haverstraw, NY/Etats-Unis (21 aut.) |
| DT : | Publication en série; Niveau analytique |
| SO : | Journal of bone and mineral research : (Print); ISSN 0884-0431; Coden JBMREJ; Etats-Unis; Da. 2012; Vol. 27; No. 3; Pp. 645-653; Bibl. 28 ref. |
| LA : | Anglais |
| EA : | Previous fractures of the hip, spine, or wrist are well-recognized predictors of future fracture, but the role of other fracture sites is less clear. We sought to assess the relationship between prior fracture at 10 skeletal locations and incident fracture. The Global Longitudinal Study of Osteoporosis in Women (GLOW) is an observational cohort study being conducted in 17 physician practices in 10 countries. Women aged ≥55 years answered questionnaires at baseline and at 1 and/or 2 years (fractures in previous year). Of 60,393 women enrolled, follow-up data were available for 51,762. Of these, 17.6%, 4.0%, and 1.6% had suffered 1, 2, or >3 fractures, respectively, since age 45 years. During the first 2 years of follow-up, 3149 women suffered 3683 incident fractures. Compared with women with no previous fractures, women with 1, 2, or ≥3 prior fractures were 1.8-, 3.0-, and 4.8-fold more likely to have any incident fracture; those with >3 prior fractures were 9.1-fold more likely to sustain a new vertebral fracture. Nine of 10 prior fracture locations were associated with an incident fracture. The strongest predictors of incident spine and hip fractures were prior spine fracture (hazard ratio [HR] = 7.3) and hip (HR = 3.5). Prior rib fractures were associated with a 2.3-fold risk of subsequent vertebral fracture, and previous upper leg fracture predicted a 2.2-fold increased risk of hip fracture. Women with a history of ankle fracture were at 1.8-fold risk of future fracture of a weight-bearing bone. Our findings suggest that a broad range of prior fracture sites are associated with an increased risk of incident fractures, with important implications for clinical assessments and risk model development. |
| CC : | 002A23A |
| FD : | Fracture; Site; Ostéoporose; Femelle; Mammalia; Système ostéoarticulaire |
| FG : | Vertebrata; Pathologie du système ostéoarticulaire; Traumatisme |
| ED : | Fracture; Site; Osteoporosis; Female; Mammalia; Osteoarticular system |
| EG : | Vertebrata; Diseases of the osteoarticular system; Trauma |
| SD : | Fractura; Sitio; Osteoporosis; Hembra; Mammalia; Sistema osteoarticular |
| LO : | INIST-21114.354000508401570150 |
| ID : | 12-0152233 |
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Pascal:12-0152233Le document en format XML
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Coen Netelenbos</name><affiliation><inist:fA14 i1="12"><s1>Department of Endocrinology, VU University Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>13 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Pfeilschifter, Johannes" sort="Pfeilschifter, Johannes" uniqKey="Pfeilschifter J" first="Johannes" last="Pfeilschifter">Johannes Pfeilschifter</name><affiliation><inist:fA14 i1="13"><s1>Department of Internal Medicine III, Alfried Krupp Krankenhaus</s1><s2>Essen</s2><s3>DEU</s3><sZ>14 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Rossini, Maurizio" sort="Rossini, Maurizio" uniqKey="Rossini M" first="Maurizio" last="Rossini">Maurizio Rossini</name><affiliation><inist:fA14 i1="14"><s1>Department of Rheumatology, University of Verona, Ospedale</s1><s2>Verona, Valeggio</s2><s3>ITA</s3><sZ>15 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Roux, Christian" sort="Roux, Christian" uniqKey="Roux C" first="Christian" last="Roux">Christian Roux</name><affiliation><inist:fA14 i1="15"><s1>Paris Descartes University, Cochin Hospital</s1><s2>Paris</s2><s3>FRA</s3><sZ>16 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Sambrook, Philip N" sort="Sambrook, Philip N" uniqKey="Sambrook P" first="Philip N." last="Sambrook">Philip N. Sambrook</name><affiliation><inist:fA14 i1="16"><s1>University of Sydney-Royal North Shore Hospital, St. Leonards</s1><s2>Sydney, NSW</s2><s3>AUS</s3><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Silverman, Stuart" sort="Silverman, Stuart" uniqKey="Silverman S" first="Stuart" last="Silverman">Stuart Silverman</name><affiliation><inist:fA14 i1="17"><s1>Department of Rheumatology, Cedars-Sinai Medical Center</s1><s2>Los Angeles, CA</s2><s3>USA</s3><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Siris, Ethel S" sort="Siris, Ethel S" uniqKey="Siris E" first="Ethel S." last="Siris">Ethel S. Siris</name><affiliation><inist:fA14 i1="18"><s1>Columbia University Medical Center</s1><s2>New York, NY</s2><s3>USA</s3><sZ>19 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Watts, Nelson B" sort="Watts, Nelson B" uniqKey="Watts N" first="Nelson B." last="Watts">Nelson B. Watts</name><affiliation><inist:fA14 i1="19"><s1>Bone Health and Osteoporosis Center, University of Cincinnati</s1><s2>Cincinnati, OH</s2><s3>USA</s3><sZ>20 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Lindsay, Robert" sort="Lindsay, Robert" uniqKey="Lindsay R" first="Robert" last="Lindsay">Robert Lindsay</name><affiliation><inist:fA14 i1="20"><s1>Regional Bone Center, Helen Hayes Hospital</s1><s2>West Haverstraw, NY</s2><s3>USA</s3><sZ>21 aut.</sZ></inist:fA14></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0152233</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0152233 INIST</idno><idno type="RBID">Pascal:12-0152233</idno><idno type="wicri:Area/PascalFrancis/Corpus">001503</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Previous Fractures at Multiple Sites Increase the Risk for Subsequent Fractures: The Global Longitudinal Study of Osteoporosis in Women</title><author><name sortKey="Gehlbach, Stephen" sort="Gehlbach, Stephen" uniqKey="Gehlbach S" first="Stephen" last="Gehlbach">Stephen Gehlbach</name><affiliation><inist:fA14 i1="01"><s1>Center for Outcomes Research, University of Massachusetts Medical School</s1><s2>Worcester, MA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Saag, Kenneth G" sort="Saag, Kenneth G" uniqKey="Saag K" first="Kenneth G." last="Saag">Kenneth G. Saag</name><affiliation><inist:fA14 i1="02"><s1>Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham</s1><s2>Birmingham, AL</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Adachi, Jonathan D" sort="Adachi, Jonathan D" uniqKey="Adachi J" first="Jonathan D." last="Adachi">Jonathan D. Adachi</name><affiliation><inist:fA14 i1="03"><s1>St. Joseph's Healthcare, McMaster University</s1><s2>Hamilton, ON</s2><s3>CAN</s3><sZ>3 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Hooven, Fred H" sort="Hooven, Fred H" uniqKey="Hooven F" first="Fred H." last="Hooven">Fred H. Hooven</name><affiliation><inist:fA14 i1="01"><s1>Center for Outcomes Research, University of Massachusetts Medical School</s1><s2>Worcester, MA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Flahive, Julie" sort="Flahive, Julie" uniqKey="Flahive J" first="Julie" last="Flahive">Julie Flahive</name><affiliation><inist:fA14 i1="01"><s1>Center for Outcomes Research, University of Massachusetts Medical School</s1><s2>Worcester, MA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Boonen, Steven" sort="Boonen, Steven" uniqKey="Boonen S" first="Steven" last="Boonen">Steven Boonen</name><affiliation><inist:fA14 i1="04"><s1>Universiteit Leuven</s1><s2>Leuven</s2><s3>BEL</s3><sZ>6 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Chapurlat, Roland D" sort="Chapurlat, Roland D" uniqKey="Chapurlat R" first="Roland D." last="Chapurlat">Roland D. Chapurlat</name><affiliation><inist:fA14 i1="05"><s1>Division of Rheumatology, INSERM UMR 1033, Université de Lyon, Hospices Civils de Lyon, Hôpital E Herriot</s1><s2>Lyon</s2><s3>FRA</s3><sZ>7 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Compston, Juliet E" sort="Compston, Juliet E" uniqKey="Compston J" first="Juliet E." last="Compston">Juliet E. Compston</name><affiliation><inist:fA14 i1="06"><s1>Cambridge University Hospitals NHS Foundation Trust</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>8 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Cooper, Cyrus" sort="Cooper, Cyrus" uniqKey="Cooper C" first="Cyrus" last="Cooper">Cyrus Cooper</name><affiliation><inist:fA14 i1="07"><s1>MRC Lifecourse Epidemiology Unit, University of Southampton</s1><s2>Southampton</s2><s3>GBR</s3><sZ>9 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Diez Perez, Adolfo" sort="Diez Perez, Adolfo" uniqKey="Diez Perez A" first="Adolfo" last="Diez-Perez">Adolfo Diez-Perez</name><affiliation><inist:fA14 i1="08"><s1>Hospital del Mar-IMIM-Autonomous University of Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>10 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="09"><s1>RETICEF, ISCIII</s1><s2>Madrid</s2><s3>ESP</s3><sZ>10 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Greenspan, Susan L" sort="Greenspan, Susan L" uniqKey="Greenspan S" first="Susan L." last="Greenspan">Susan L. Greenspan</name><affiliation><inist:fA14 i1="10"><s1>University of Pittsburgh</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Lacroix, Andrea Z" sort="Lacroix, Andrea Z" uniqKey="Lacroix A" first="Andrea Z." last="Lacroix">Andrea Z. Lacroix</name><affiliation><inist:fA14 i1="11"><s1>Fred Hutchinson Cancer Research Center</s1><s2>Seattle, WA</s2><s3>USA</s3><sZ>12 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Netelenbos, J Coen" sort="Netelenbos, J Coen" uniqKey="Netelenbos J" first="J. Coen" last="Netelenbos">J. Coen Netelenbos</name><affiliation><inist:fA14 i1="12"><s1>Department of Endocrinology, VU University Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>13 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Pfeilschifter, Johannes" sort="Pfeilschifter, Johannes" uniqKey="Pfeilschifter J" first="Johannes" last="Pfeilschifter">Johannes Pfeilschifter</name><affiliation><inist:fA14 i1="13"><s1>Department of Internal Medicine III, Alfried Krupp Krankenhaus</s1><s2>Essen</s2><s3>DEU</s3><sZ>14 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Rossini, Maurizio" sort="Rossini, Maurizio" uniqKey="Rossini M" first="Maurizio" last="Rossini">Maurizio Rossini</name><affiliation><inist:fA14 i1="14"><s1>Department of Rheumatology, University of Verona, Ospedale</s1><s2>Verona, Valeggio</s2><s3>ITA</s3><sZ>15 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Roux, Christian" sort="Roux, Christian" uniqKey="Roux C" first="Christian" last="Roux">Christian Roux</name><affiliation><inist:fA14 i1="15"><s1>Paris Descartes University, Cochin Hospital</s1><s2>Paris</s2><s3>FRA</s3><sZ>16 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Sambrook, Philip N" sort="Sambrook, Philip N" uniqKey="Sambrook P" first="Philip N." last="Sambrook">Philip N. Sambrook</name><affiliation><inist:fA14 i1="16"><s1>University of Sydney-Royal North Shore Hospital, St. Leonards</s1><s2>Sydney, NSW</s2><s3>AUS</s3><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Silverman, Stuart" sort="Silverman, Stuart" uniqKey="Silverman S" first="Stuart" last="Silverman">Stuart Silverman</name><affiliation><inist:fA14 i1="17"><s1>Department of Rheumatology, Cedars-Sinai Medical Center</s1><s2>Los Angeles, CA</s2><s3>USA</s3><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Siris, Ethel S" sort="Siris, Ethel S" uniqKey="Siris E" first="Ethel S." last="Siris">Ethel S. Siris</name><affiliation><inist:fA14 i1="18"><s1>Columbia University Medical Center</s1><s2>New York, NY</s2><s3>USA</s3><sZ>19 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Watts, Nelson B" sort="Watts, Nelson B" uniqKey="Watts N" first="Nelson B." last="Watts">Nelson B. Watts</name><affiliation><inist:fA14 i1="19"><s1>Bone Health and Osteoporosis Center, University of Cincinnati</s1><s2>Cincinnati, OH</s2><s3>USA</s3><sZ>20 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Lindsay, Robert" sort="Lindsay, Robert" uniqKey="Lindsay R" first="Robert" last="Lindsay">Robert Lindsay</name><affiliation><inist:fA14 i1="20"><s1>Regional Bone Center, Helen Hayes Hospital</s1><s2>West Haverstraw, NY</s2><s3>USA</s3><sZ>21 aut.</sZ></inist:fA14></affiliation></author></analytic><series><title level="j" type="main">Journal of bone and mineral research : (Print)</title><title level="j" type="abbreviated">J. bone miner. res. : (Print)</title><idno type="ISSN">0884-0431</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of bone and mineral research : (Print)</title><title level="j" type="abbreviated">J. bone miner. res. : (Print)</title><idno type="ISSN">0884-0431</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Female</term><term>Fracture</term><term>Mammalia</term><term>Osteoarticular system</term><term>Osteoporosis</term><term>Site</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Fracture</term><term>Site</term><term>Ostéoporose</term><term>Femelle</term><term>Mammalia</term><term>Système ostéoarticulaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Previous fractures of the hip, spine, or wrist are well-recognized predictors of future fracture, but the role of other fracture sites is less clear. We sought to assess the relationship between prior fracture at 10 skeletal locations and incident fracture. The Global Longitudinal Study of Osteoporosis in Women (GLOW) is an observational cohort study being conducted in 17 physician practices in 10 countries. Women aged ≥55 years answered questionnaires at baseline and at 1 and/or 2 years (fractures in previous year). Of 60,393 women enrolled, follow-up data were available for 51,762. Of these, 17.6%, 4.0%, and 1.6% had suffered 1, 2, or >3 fractures, respectively, since age 45 years. During the first 2 years of follow-up, 3149 women suffered 3683 incident fractures. Compared with women with no previous fractures, women with 1, 2, or ≥3 prior fractures were 1.8-, 3.0-, and 4.8-fold more likely to have any incident fracture; those with >3 prior fractures were 9.1-fold more likely to sustain a new vertebral fracture. Nine of 10 prior fracture locations were associated with an incident fracture. The strongest predictors of incident spine and hip fractures were prior spine fracture (hazard ratio [HR] = 7.3) and hip (HR = 3.5). Prior rib fractures were associated with a 2.3-fold risk of subsequent vertebral fracture, and previous upper leg fracture predicted a 2.2-fold increased risk of hip fracture. Women with a history of ankle fracture were at 1.8-fold risk of future fracture of a weight-bearing bone. Our findings suggest that a broad range of prior fracture sites are associated with an increased risk of incident fractures, with important implications for clinical assessments and risk model development.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0884-0431</s0></fA01><fA02 i1="01"><s0>JBMREJ</s0></fA02><fA03 i2="1"><s0>J. bone miner. res. : (Print)</s0></fA03><fA05><s2>27</s2></fA05><fA06><s2>3</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Previous Fractures at Multiple Sites Increase the Risk for Subsequent Fractures: The Global Longitudinal Study of Osteoporosis in Women</s1></fA08><fA11 i1="01" i2="1"><s1>GEHLBACH (Stephen)</s1></fA11><fA11 i1="02" i2="1"><s1>SAAG (Kenneth G.)</s1></fA11><fA11 i1="03" i2="1"><s1>ADACHI (Jonathan D.)</s1></fA11><fA11 i1="04" i2="1"><s1>HOOVEN (Fred H.)</s1></fA11><fA11 i1="05" i2="1"><s1>FLAHIVE (Julie)</s1></fA11><fA11 i1="06" i2="1"><s1>BOONEN (Steven)</s1></fA11><fA11 i1="07" i2="1"><s1>CHAPURLAT (Roland D.)</s1></fA11><fA11 i1="08" i2="1"><s1>COMPSTON (Juliet E.)</s1></fA11><fA11 i1="09" i2="1"><s1>COOPER (Cyrus)</s1></fA11><fA11 i1="10" i2="1"><s1>DIEZ-PEREZ (Adolfo)</s1></fA11><fA11 i1="11" i2="1"><s1>GREENSPAN (Susan L.)</s1></fA11><fA11 i1="12" i2="1"><s1>LACROIX (Andrea Z.)</s1></fA11><fA11 i1="13" i2="1"><s1>NETELENBOS (J. Coen)</s1></fA11><fA11 i1="14" i2="1"><s1>PFEILSCHIFTER (Johannes)</s1></fA11><fA11 i1="15" i2="1"><s1>ROSSINI (Maurizio)</s1></fA11><fA11 i1="16" i2="1"><s1>ROUX (Christian)</s1></fA11><fA11 i1="17" i2="1"><s1>SAMBROOK (Philip N.)</s1></fA11><fA11 i1="18" i2="1"><s1>SILVERMAN (Stuart)</s1></fA11><fA11 i1="19" i2="1"><s1>SIRIS (Ethel S.)</s1></fA11><fA11 i1="20" i2="1"><s1>WATTS (Nelson B.)</s1></fA11><fA11 i1="21" i2="1"><s1>LINDSAY (Robert)</s1></fA11><fA14 i1="01"><s1>Center for Outcomes Research, University of Massachusetts Medical School</s1><s2>Worcester, MA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></fA14><fA14 i1="02"><s1>Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham</s1><s2>Birmingham, AL</s2><s3>USA</s3><sZ>2 aut.</sZ></fA14><fA14 i1="03"><s1>St. Joseph's Healthcare, McMaster University</s1><s2>Hamilton, ON</s2><s3>CAN</s3><sZ>3 aut.</sZ></fA14><fA14 i1="04"><s1>Universiteit Leuven</s1><s2>Leuven</s2><s3>BEL</s3><sZ>6 aut.</sZ></fA14><fA14 i1="05"><s1>Division of Rheumatology, INSERM UMR 1033, Université de Lyon, Hospices Civils de Lyon, Hôpital E Herriot</s1><s2>Lyon</s2><s3>FRA</s3><sZ>7 aut.</sZ></fA14><fA14 i1="06"><s1>Cambridge University Hospitals NHS Foundation Trust</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>8 aut.</sZ></fA14><fA14 i1="07"><s1>MRC Lifecourse Epidemiology Unit, University of Southampton</s1><s2>Southampton</s2><s3>GBR</s3><sZ>9 aut.</sZ></fA14><fA14 i1="08"><s1>Hospital del Mar-IMIM-Autonomous University of Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>10 aut.</sZ></fA14><fA14 i1="09"><s1>RETICEF, ISCIII</s1><s2>Madrid</s2><s3>ESP</s3><sZ>10 aut.</sZ></fA14><fA14 i1="10"><s1>University of Pittsburgh</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>11 aut.</sZ></fA14><fA14 i1="11"><s1>Fred Hutchinson Cancer Research Center</s1><s2>Seattle, WA</s2><s3>USA</s3><sZ>12 aut.</sZ></fA14><fA14 i1="12"><s1>Department of Endocrinology, VU University Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>13 aut.</sZ></fA14><fA14 i1="13"><s1>Department of Internal Medicine III, Alfried Krupp Krankenhaus</s1><s2>Essen</s2><s3>DEU</s3><sZ>14 aut.</sZ></fA14><fA14 i1="14"><s1>Department of Rheumatology, University of Verona, Ospedale</s1><s2>Verona, Valeggio</s2><s3>ITA</s3><sZ>15 aut.</sZ></fA14><fA14 i1="15"><s1>Paris Descartes University, Cochin Hospital</s1><s2>Paris</s2><s3>FRA</s3><sZ>16 aut.</sZ></fA14><fA14 i1="16"><s1>University of Sydney-Royal North Shore Hospital, St. Leonards</s1><s2>Sydney, NSW</s2><s3>AUS</s3><sZ>17 aut.</sZ></fA14><fA14 i1="17"><s1>Department of Rheumatology, Cedars-Sinai Medical Center</s1><s2>Los Angeles, CA</s2><s3>USA</s3><sZ>18 aut.</sZ></fA14><fA14 i1="18"><s1>Columbia University Medical Center</s1><s2>New York, NY</s2><s3>USA</s3><sZ>19 aut.</sZ></fA14><fA14 i1="19"><s1>Bone Health and Osteoporosis Center, University of Cincinnati</s1><s2>Cincinnati, OH</s2><s3>USA</s3><sZ>20 aut.</sZ></fA14><fA14 i1="20"><s1>Regional Bone Center, Helen Hayes Hospital</s1><s2>West Haverstraw, NY</s2><s3>USA</s3><sZ>21 aut.</sZ></fA14><fA20><s1>645-653</s1></fA20><fA21><s1>2012</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>21114</s2><s5>354000508401570150</s5></fA43><fA44><s0>0000</s0><s1>© 2012 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>28 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>12-0152233</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Journal of bone and mineral research : (Print)</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Previous fractures of the hip, spine, or wrist are well-recognized predictors of future fracture, but the role of other fracture sites is less clear. We sought to assess the relationship between prior fracture at 10 skeletal locations and incident fracture. The Global Longitudinal Study of Osteoporosis in Women (GLOW) is an observational cohort study being conducted in 17 physician practices in 10 countries. Women aged ≥55 years answered questionnaires at baseline and at 1 and/or 2 years (fractures in previous year). Of 60,393 women enrolled, follow-up data were available for 51,762. Of these, 17.6%, 4.0%, and 1.6% had suffered 1, 2, or >3 fractures, respectively, since age 45 years. During the first 2 years of follow-up, 3149 women suffered 3683 incident fractures. Compared with women with no previous fractures, women with 1, 2, or ≥3 prior fractures were 1.8-, 3.0-, and 4.8-fold more likely to have any incident fracture; those with >3 prior fractures were 9.1-fold more likely to sustain a new vertebral fracture. Nine of 10 prior fracture locations were associated with an incident fracture. The strongest predictors of incident spine and hip fractures were prior spine fracture (hazard ratio [HR] = 7.3) and hip (HR = 3.5). Prior rib fractures were associated with a 2.3-fold risk of subsequent vertebral fracture, and previous upper leg fracture predicted a 2.2-fold increased risk of hip fracture. Women with a history of ankle fracture were at 1.8-fold risk of future fracture of a weight-bearing bone. Our findings suggest that a broad range of prior fracture sites are associated with an increased risk of incident fractures, with important implications for clinical assessments and risk model development.</s0></fC01><fC02 i1="01" i2="X"><s0>002A23A</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Fracture</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Fracture</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Fractura</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Site</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Site</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Sitio</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Ostéoporose</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Osteoporosis</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Osteoporosis</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Femelle</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Female</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Hembra</s0><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Mammalia</s0><s2>NS</s2><s5>05</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Mammalia</s0><s2>NS</s2><s5>05</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Mammalia</s0><s2>NS</s2><s5>05</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Système ostéoarticulaire</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Osteoarticular system</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Sistema osteoarticular</s0><s5>06</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Pathologie du système ostéoarticulaire</s0><s5>20</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Diseases of the osteoarticular system</s0><s5>20</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Sistema osteoarticular patología</s0><s5>20</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Traumatisme</s0><s5>21</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Trauma</s0><s5>21</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Traumatismo</s0><s5>21</s5></fC07><fN21><s1>114</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard><server><NO>PASCAL 12-0152233 INIST</NO><ET>Previous Fractures at Multiple Sites Increase the Risk for Subsequent Fractures: The Global Longitudinal Study of Osteoporosis in Women</ET><AU>GEHLBACH (Stephen); SAAG (Kenneth G.); ADACHI (Jonathan D.); HOOVEN (Fred H.); FLAHIVE (Julie); BOONEN (Steven); CHAPURLAT (Roland D.); COMPSTON (Juliet E.); COOPER (Cyrus); DIEZ-PEREZ (Adolfo); GREENSPAN (Susan L.); LACROIX (Andrea Z.); NETELENBOS (J. Coen); PFEILSCHIFTER (Johannes); ROSSINI (Maurizio); ROUX (Christian); SAMBROOK (Philip N.); SILVERMAN (Stuart); SIRIS (Ethel S.); WATTS (Nelson B.); LINDSAY (Robert)</AU><AF>Center for Outcomes Research, University of Massachusetts Medical School/Worcester, MA/Etats-Unis (1 aut., 4 aut., 5 aut.); Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham/Birmingham, AL/Etats-Unis (2 aut.); St. Joseph's Healthcare, McMaster University/Hamilton, ON/Canada (3 aut.); Universiteit Leuven/Leuven/Belgique (6 aut.); Division of Rheumatology, INSERM UMR 1033, Université de Lyon, Hospices Civils de Lyon, Hôpital E Herriot/Lyon/France (7 aut.); Cambridge University Hospitals NHS Foundation Trust/Cambridge/Royaume-Uni (8 aut.); MRC Lifecourse Epidemiology Unit, University of Southampton/Southampton/Royaume-Uni (9 aut.); Hospital del Mar-IMIM-Autonomous University of Barcelona/Barcelona/Espagne (10 aut.); RETICEF, ISCIII/Madrid/Espagne (10 aut.); University of Pittsburgh/Pittsburgh, PA/Etats-Unis (11 aut.); Fred Hutchinson Cancer Research Center/Seattle, WA/Etats-Unis (12 aut.); Department of Endocrinology, VU University Medical Center/Amsterdam/Pays-Bas (13 aut.); Department of Internal Medicine III, Alfried Krupp Krankenhaus/Essen/Allemagne (14 aut.); Department of Rheumatology, University of Verona, Ospedale/Verona, Valeggio/Italie (15 aut.); Paris Descartes University, Cochin Hospital/Paris/France (16 aut.); University of Sydney-Royal North Shore Hospital, St. Leonards/Sydney, NSW/Australie (17 aut.); Department of Rheumatology, Cedars-Sinai Medical Center/Los Angeles, CA/Etats-Unis (18 aut.); Columbia University Medical Center/New York, NY/Etats-Unis (19 aut.); Bone Health and Osteoporosis Center, University of Cincinnati/Cincinnati, OH/Etats-Unis (20 aut.); Regional Bone Center, Helen Hayes Hospital/West Haverstraw, NY/Etats-Unis (21 aut.)</AF><DT>Publication en série; Niveau analytique</DT><SO>Journal of bone and mineral research : (Print); ISSN 0884-0431; Coden JBMREJ; Etats-Unis; Da. 2012; Vol. 27; No. 3; Pp. 645-653; Bibl. 28 ref.</SO><LA>Anglais</LA><EA>Previous fractures of the hip, spine, or wrist are well-recognized predictors of future fracture, but the role of other fracture sites is less clear. We sought to assess the relationship between prior fracture at 10 skeletal locations and incident fracture. The Global Longitudinal Study of Osteoporosis in Women (GLOW) is an observational cohort study being conducted in 17 physician practices in 10 countries. Women aged ≥55 years answered questionnaires at baseline and at 1 and/or 2 years (fractures in previous year). Of 60,393 women enrolled, follow-up data were available for 51,762. Of these, 17.6%, 4.0%, and 1.6% had suffered 1, 2, or >3 fractures, respectively, since age 45 years. During the first 2 years of follow-up, 3149 women suffered 3683 incident fractures. Compared with women with no previous fractures, women with 1, 2, or ≥3 prior fractures were 1.8-, 3.0-, and 4.8-fold more likely to have any incident fracture; those with >3 prior fractures were 9.1-fold more likely to sustain a new vertebral fracture. Nine of 10 prior fracture locations were associated with an incident fracture. The strongest predictors of incident spine and hip fractures were prior spine fracture (hazard ratio [HR] = 7.3) and hip (HR = 3.5). Prior rib fractures were associated with a 2.3-fold risk of subsequent vertebral fracture, and previous upper leg fracture predicted a 2.2-fold increased risk of hip fracture. Women with a history of ankle fracture were at 1.8-fold risk of future fracture of a weight-bearing bone. Our findings suggest that a broad range of prior fracture sites are associated with an increased risk of incident fractures, with important implications for clinical assessments and risk model development.</EA><CC>002A23A</CC><FD>Fracture; Site; Ostéoporose; Femelle; Mammalia; Système ostéoarticulaire</FD><FG>Vertebrata; Pathologie du système ostéoarticulaire; Traumatisme</FG><ED>Fracture; Site; Osteoporosis; Female; Mammalia; Osteoarticular system</ED><EG>Vertebrata; Diseases of the osteoarticular system; Trauma</EG><SD>Fractura; Sitio; Osteoporosis; Hembra; Mammalia; Sistema osteoarticular</SD><LO>INIST-21114.354000508401570150</LO><ID>12-0152233</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
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