AustralieFrV1, PascalFrancis, Corpus, bibRecord, 000B09

Pharmacological blocking of the osteoclastic biocorrosion of surgical stainless steel in vitro

Identifieur interne : 000B09 ( PascalFrancis/Corpus ); précédent : 000B08; suivant : 000B10

Pharmacological blocking of the osteoclastic biocorrosion of surgical stainless steel in vitro

Auteurs : S. Lionetto ; A. Little ; G. Moriceau ; D. Heymann ; M. Decurtins ; M. Plecko ; L. Filgueira ; D. Cadosch

Source :

Journal of biomedical materials research. Part A [ 1549-3296 ] ; 2013.

RBID : Pascal:13-0158452

Descripteurs français

Pascal (Inist)
- Corrosion, Chirurgie, Acier inoxydable, In vitro, Ion métallique, Ostéoclaste, Bisphosphonates, Génie biomédical, Biomatériau, Traitement.

English descriptors

KwdEn :
- Biomaterial, Biomedical engineering, Bisphosphonates, Corrosion, In vitro, Metal ion, Osteoclast, Stainless steel, Surgery, Treatment.

Abstract

In vitro studies suggest that human osteoclasts (OC) are able to corrode surgical stainless steel 316L (SS). The aim of this study was to investigate whether osteoclastic biocorrosion can be blocked pharmacologically. Human OCs were generated in vitro from peripheral blood monocytic cells (PBMCs) in the presence of OC differentiation cytokines. The osteoclastic viability, differentiation, and resorptive function (on both bone and SS) were assessed using standard colorimetric cell viability assay 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenil)-2H-tetrazolium, inner salt (MTS), fluorescence microscopy, tartrate-resistant acid phosphatase expression (flow cytometry), and scanning electron microscopy. OCs cultured on SS were exposed to nontoxic concentrations of bafilomycin A1, amiloride hydrochloride, or zoledronic acid. The extent of biocorrosion was quantified using atomic emission spectrometry (to measure the concentration of metal ions released into the supernatant) and scanning electron microscopy. PBMCs differentiated into mature and functional OC in the presence of all the drugs used. Osteoclastic resorption of SS was noted with differences in the resorption pattern for all drug treatments. Under the drug treatments, single areas of osteoclastic resorption were larger in size but less abundant when compared with positive controls. None of the drugs used were able to inhibit osteoclastic biocorrosion of SS.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A03		`1`		`@0 J. biomed. mater. res., Part A`
A05				`@2 101`
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A08	`01`	`1`	`ENG`	`@1 Pharmacological blocking of the osteoclastic biocorrosion of surgical stainless steel in vitro`
A11	`01`	`1`		`@1 LIONETTO (S.)`
A11	`02`	`1`		`@1 LITTLE (A.)`
A11	`03`	`1`		`@1 MORICEAU (G.)`
A11	`04`	`1`		`@1 HEYMANN (D.)`
A11	`05`	`1`		`@1 DECURTINS (M.)`
A11	`06`	`1`		`@1 PLECKO (M.)`
A11	`07`	`1`		`@1 FILGUEIRA (L.)`
A11	`08`	`1`		`@1 CADOSCH (D.)`
A14	`01`			`@1 Department of Surgery, Spitalregion Fürstenland Toggenburg @3 CHE @Z 1 aut.`
A14	`02`			`@1 School of Anatomy and Human Biology, University of Western Australia @3 AUS @Z 2 aut. @Z 7 aut. @Z 8 aut.`
A14	`03`			`@1 Physiopathology of Bone Resorption Laboratory, University of Nantes @3 FRA @Z 3 aut. @Z 4 aut.`
A14	`04`			`@1 Department of Surgery, Kantonsspital Winterthur @3 CHE @Z 5 aut.`
A14	`05`			`@1 Clinic of Trauma Surgery, University Hospital Zurich, Ramistrasse 100 @2 8091 Zurich @3 CHE @Z 6 aut. @Z 8 aut.`
A20				`@1 991-997`
A21				`@1 2013`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 13764A @5 354000500656490090`
A44				`@0 0000 @1 © 2013 INIST-CNRS. All rights reserved.`
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C01	`01`		`ENG`	@0 In vitro studies suggest that human osteoclasts (OC) are able to corrode surgical stainless steel 316L (SS). The aim of this study was to investigate whether osteoclastic biocorrosion can be blocked pharmacologically. Human OCs were generated in vitro from peripheral blood monocytic cells (PBMCs) in the presence of OC differentiation cytokines. The osteoclastic viability, differentiation, and resorptive function (on both bone and SS) were assessed using standard colorimetric cell viability assay 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenil)-2H-tetrazolium, inner salt (MTS), fluorescence microscopy, tartrate-resistant acid phosphatase expression (flow cytometry), and scanning electron microscopy. OCs cultured on SS were exposed to nontoxic concentrations of bafilomycin A1, amiloride hydrochloride, or zoledronic acid. The extent of biocorrosion was quantified using atomic emission spectrometry (to measure the concentration of metal ions released into the supernatant) and scanning electron microscopy. PBMCs differentiated into mature and functional OC in the presence of all the drugs used. Osteoclastic resorption of SS was noted with differences in the resorption pattern for all drug treatments. Under the drug treatments, single areas of osteoclastic resorption were larger in size but less abundant when compared with positive controls. None of the drugs used were able to inhibit osteoclastic biocorrosion of SS.
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C02	`03`	`X`		`@0 002B02L`
C02	`04`	`X`		`@0 240`
C03	`01`	`X`	`FRE`	`@0 Corrosion @5 07`
C03	`01`	`X`	`ENG`	`@0 Corrosion @5 07`
C03	`01`	`X`	`GER`	`@0 Korrosion @5 07`
C03	`01`	`X`	`SPA`	`@0 Corrosión @5 07`
C03	`02`	`X`	`FRE`	`@0 Chirurgie @5 08`
C03	`02`	`X`	`ENG`	`@0 Surgery @5 08`
C03	`02`	`X`	`SPA`	`@0 Cirugía @5 08`
C03	`03`	`X`	`FRE`	`@0 Acier inoxydable @5 09`
C03	`03`	`X`	`ENG`	`@0 Stainless steel @5 09`
C03	`03`	`X`	`GER`	`@0 Nichtrostender Stahl @5 09`
C03	`03`	`X`	`SPA`	`@0 Acero inoxidable @5 09`
C03	`04`	`X`	`FRE`	`@0 In vitro @5 13`
C03	`04`	`X`	`ENG`	`@0 In vitro @5 13`
C03	`04`	`X`	`SPA`	`@0 In vitro @5 13`
C03	`05`	`X`	`FRE`	`@0 Ion métallique @5 14`
C03	`05`	`X`	`ENG`	`@0 Metal ion @5 14`
C03	`05`	`X`	`SPA`	`@0 Ión metálico @5 14`
C03	`06`	`X`	`FRE`	`@0 Ostéoclaste @5 15`
C03	`06`	`X`	`ENG`	`@0 Osteoclast @5 15`
C03	`06`	`X`	`SPA`	`@0 Osteoclasto @5 15`
C03	`07`	`X`	`FRE`	`@0 Bisphosphonates @5 16`
C03	`07`	`X`	`ENG`	`@0 Bisphosphonates @5 16`
C03	`07`	`X`	`SPA`	`@0 Bisfosfonatos @5 16`
C03	`08`	`X`	`FRE`	`@0 Génie biomédical @5 17`
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C03	`09`	`X`	`FRE`	`@0 Biomatériau @5 30`
C03	`09`	`X`	`ENG`	`@0 Biomaterial @5 30`
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C03	`10`	`X`	`FRE`	`@0 Traitement @5 31`
C03	`10`	`X`	`ENG`	`@0 Treatment @5 31`
C03	`10`	`X`	`GER`	`@0 Aufbereiten @5 31`
C03	`10`	`X`	`SPA`	`@0 Tratamiento @5 31`
C07	`01`	`X`	`FRE`	`@0 Os @5 37`
C07	`01`	`X`	`ENG`	`@0 Bone @5 37`
C07	`01`	`X`	`SPA`	`@0 Hueso @5 37`
C07	`02`	`X`	`FRE`	`@0 Système ostéoarticulaire @5 38`
C07	`02`	`X`	`ENG`	`@0 Osteoarticular system @5 38`
C07	`02`	`X`	`SPA`	`@0 Sistema osteoarticular @5 38`
N21				`@1 140`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 13-0158452 INIST
ET :	Pharmacological blocking of the osteoclastic biocorrosion of surgical stainless steel in vitro
AU :	LIONETTO (S.); LITTLE (A.); MORICEAU (G.); HEYMANN (D.); DECURTINS (M.); PLECKO (M.); FILGUEIRA (L.); CADOSCH (D.)
AF :	Department of Surgery, Spitalregion Fürstenland Toggenburg/Suisse (1 aut.); School of Anatomy and Human Biology, University of Western Australia/Australie (2 aut., 7 aut., 8 aut.); Physiopathology of Bone Resorption Laboratory, University of Nantes/France (3 aut., 4 aut.); Department of Surgery, Kantonsspital Winterthur/Suisse (5 aut.); Clinic of Trauma Surgery, University Hospital Zurich, Ramistrasse 100/8091 Zurich/Suisse (6 aut., 8 aut.)
DT :	Publication en série; Niveau analytique
SO :	Journal of biomedical materials research. Part A; ISSN 1549-3296; Etats-Unis; Da. 2013; Vol. 101; No. 4; Pp. 991-997; Bibl. 20 ref.
LA :	Anglais
EA :	In vitro studies suggest that human osteoclasts (OC) are able to corrode surgical stainless steel 316L (SS). The aim of this study was to investigate whether osteoclastic biocorrosion can be blocked pharmacologically. Human OCs were generated in vitro from peripheral blood monocytic cells (PBMCs) in the presence of OC differentiation cytokines. The osteoclastic viability, differentiation, and resorptive function (on both bone and SS) were assessed using standard colorimetric cell viability assay 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfopheni l)-2H-tetrazolium, inner salt (MTS), fluorescence microscopy, tartrate-resistant acid phosphatase expression (flow cytometry), and scanning electron microscopy. OCs cultured on SS were exposed to nontoxic concentrations of bafilomycin A1, amiloride hydrochloride, or zoledronic acid. The extent of biocorrosion was quantified using atomic emission spectrometry (to measure the concentration of metal ions released into the supernatant) and scanning electron microscopy. PBMCs differentiated into mature and functional OC in the presence of all the drugs used. Osteoclastic resorption of SS was noted with differences in the resorption pattern for all drug treatments. Under the drug treatments, single areas of osteoclastic resorption were larger in size but less abundant when compared with positive controls. None of the drugs used were able to inhibit osteoclastic biocorrosion of SS.
CC :	002B25M; 001D11E; 002B02L; 240
FD :	Corrosion; Chirurgie; Acier inoxydable; In vitro; Ion métallique; Ostéoclaste; Bisphosphonates; Génie biomédical; Biomatériau; Traitement
FG :	Os; Système ostéoarticulaire
ED :	Corrosion; Surgery; Stainless steel; In vitro; Metal ion; Osteoclast; Bisphosphonates; Biomedical engineering; Biomaterial; Treatment
EG :	Bone; Osteoarticular system
GD :	Korrosion; Nichtrostender Stahl; Aufbereiten
SD :	Corrosión; Cirugía; Acero inoxidable; In vitro; Ión metálico; Osteoclasto; Bisfosfonatos; Ingeniería biomédica; Biomaterial; Tratamiento
LO :	INIST-13764A.354000500656490090
ID :	13-0158452

Links to Exploration step

Pascal:13-0158452

Le document en format XML

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<front><div type="abstract" xml:lang="en">In vitro studies suggest that human osteoclasts (OC) are able to corrode surgical stainless steel 316L (SS). The aim of this study was to investigate whether osteoclastic biocorrosion can be blocked pharmacologically. Human OCs were generated in vitro from peripheral blood monocytic cells (PBMCs) in the presence of OC differentiation cytokines. The osteoclastic viability, differentiation, and resorptive function (on both bone and SS) were assessed using standard colorimetric cell viability assay 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenil)-2H-tetrazolium, inner salt (MTS), fluorescence microscopy, tartrate-resistant acid phosphatase expression (flow cytometry), and scanning electron microscopy. OCs cultured on SS were exposed to nontoxic concentrations of bafilomycin A1, amiloride hydrochloride, or zoledronic acid. The extent of biocorrosion was quantified using atomic emission spectrometry (to measure the concentration of metal ions released into the supernatant) and scanning electron microscopy. PBMCs differentiated into mature and functional OC in the presence of all the drugs used. Osteoclastic resorption of SS was noted with differences in the resorption pattern for all drug treatments. Under the drug treatments, single areas of osteoclastic resorption were larger in size but less abundant when compared with positive controls. None of the drugs used were able to inhibit osteoclastic biocorrosion of SS.</div>
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<fA14 i1="04"><s1>Department of Surgery, Kantonsspital Winterthur</s1>
<s3>CHE</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Clinic of Trauma Surgery, University Hospital Zurich, Ramistrasse 100</s1>
<s2>8091 Zurich</s2>
<s3>CHE</s3>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</fA14>
<fA20><s1>991-997</s1>
</fA20>
<fA21><s1>2013</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>13764A</s2>
<s5>354000500656490090</s5>
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<fA44><s0>0000</s0>
<s1>© 2013 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>20 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>13-0158452</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Journal of biomedical materials research. Part A</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>In vitro studies suggest that human osteoclasts (OC) are able to corrode surgical stainless steel 316L (SS). The aim of this study was to investigate whether osteoclastic biocorrosion can be blocked pharmacologically. Human OCs were generated in vitro from peripheral blood monocytic cells (PBMCs) in the presence of OC differentiation cytokines. The osteoclastic viability, differentiation, and resorptive function (on both bone and SS) were assessed using standard colorimetric cell viability assay 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenil)-2H-tetrazolium, inner salt (MTS), fluorescence microscopy, tartrate-resistant acid phosphatase expression (flow cytometry), and scanning electron microscopy. OCs cultured on SS were exposed to nontoxic concentrations of bafilomycin A1, amiloride hydrochloride, or zoledronic acid. The extent of biocorrosion was quantified using atomic emission spectrometry (to measure the concentration of metal ions released into the supernatant) and scanning electron microscopy. PBMCs differentiated into mature and functional OC in the presence of all the drugs used. Osteoclastic resorption of SS was noted with differences in the resorption pattern for all drug treatments. Under the drug treatments, single areas of osteoclastic resorption were larger in size but less abundant when compared with positive controls. None of the drugs used were able to inhibit osteoclastic biocorrosion of SS.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B25M</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>001D11E</s0>
</fC02>
<fC02 i1="03" i2="X"><s0>002B02L</s0>
</fC02>
<fC02 i1="04" i2="X"><s0>240</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Corrosion</s0>
<s5>07</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Corrosion</s0>
<s5>07</s5>
</fC03>
<fC03 i1="01" i2="X" l="GER"><s0>Korrosion</s0>
<s5>07</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Corrosión</s0>
<s5>07</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Chirurgie</s0>
<s5>08</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Surgery</s0>
<s5>08</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Cirugía</s0>
<s5>08</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Acier inoxydable</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Stainless steel</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="GER"><s0>Nichtrostender Stahl</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Acero inoxidable</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>In vitro</s0>
<s5>13</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>In vitro</s0>
<s5>13</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>In vitro</s0>
<s5>13</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Ion métallique</s0>
<s5>14</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Metal ion</s0>
<s5>14</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Ión metálico</s0>
<s5>14</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Ostéoclaste</s0>
<s5>15</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Osteoclast</s0>
<s5>15</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Osteoclasto</s0>
<s5>15</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Bisphosphonates</s0>
<s5>16</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Bisphosphonates</s0>
<s5>16</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Bisfosfonatos</s0>
<s5>16</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Génie biomédical</s0>
<s5>17</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Biomedical engineering</s0>
<s5>17</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Ingeniería biomédica</s0>
<s5>17</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Biomatériau</s0>
<s5>30</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Biomaterial</s0>
<s5>30</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Biomaterial</s0>
<s5>30</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Traitement</s0>
<s5>31</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Treatment</s0>
<s5>31</s5>
</fC03>
<fC03 i1="10" i2="X" l="GER"><s0>Aufbereiten</s0>
<s5>31</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Tratamiento</s0>
<s5>31</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Os</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Bone</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Hueso</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Système ostéoarticulaire</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Osteoarticular system</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Sistema osteoarticular</s0>
<s5>38</s5>
</fC07>
<fN21><s1>140</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
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<server><NO>PASCAL 13-0158452 INIST</NO>
<ET>Pharmacological blocking of the osteoclastic biocorrosion of surgical stainless steel in vitro</ET>
<AU>LIONETTO (S.); LITTLE (A.); MORICEAU (G.); HEYMANN (D.); DECURTINS (M.); PLECKO (M.); FILGUEIRA (L.); CADOSCH (D.)</AU>
<AF>Department of Surgery, Spitalregion Fürstenland Toggenburg/Suisse (1 aut.); School of Anatomy and Human Biology, University of Western Australia/Australie (2 aut., 7 aut., 8 aut.); Physiopathology of Bone Resorption Laboratory, University of Nantes/France (3 aut., 4 aut.); Department of Surgery, Kantonsspital Winterthur/Suisse (5 aut.); Clinic of Trauma Surgery, University Hospital Zurich, Ramistrasse 100/8091 Zurich/Suisse (6 aut., 8 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Journal of biomedical materials research. Part A; ISSN 1549-3296; Etats-Unis; Da. 2013; Vol. 101; No. 4; Pp. 991-997; Bibl. 20 ref.</SO>
<LA>Anglais</LA>
<EA>In vitro studies suggest that human osteoclasts (OC) are able to corrode surgical stainless steel 316L (SS). The aim of this study was to investigate whether osteoclastic biocorrosion can be blocked pharmacologically. Human OCs were generated in vitro from peripheral blood monocytic cells (PBMCs) in the presence of OC differentiation cytokines. The osteoclastic viability, differentiation, and resorptive function (on both bone and SS) were assessed using standard colorimetric cell viability assay 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfopheni l)-2H-tetrazolium, inner salt (MTS), fluorescence microscopy, tartrate-resistant acid phosphatase expression (flow cytometry), and scanning electron microscopy. OCs cultured on SS were exposed to nontoxic concentrations of bafilomycin A1, amiloride hydrochloride, or zoledronic acid. The extent of biocorrosion was quantified using atomic emission spectrometry (to measure the concentration of metal ions released into the supernatant) and scanning electron microscopy. PBMCs differentiated into mature and functional OC in the presence of all the drugs used. Osteoclastic resorption of SS was noted with differences in the resorption pattern for all drug treatments. Under the drug treatments, single areas of osteoclastic resorption were larger in size but less abundant when compared with positive controls. None of the drugs used were able to inhibit osteoclastic biocorrosion of SS.</EA>
<CC>002B25M; 001D11E; 002B02L; 240</CC>
<FD>Corrosion; Chirurgie; Acier inoxydable; In vitro; Ion métallique; Ostéoclaste; Bisphosphonates; Génie biomédical; Biomatériau; Traitement</FD>
<FG>Os; Système ostéoarticulaire</FG>
<ED>Corrosion; Surgery; Stainless steel; In vitro; Metal ion; Osteoclast; Bisphosphonates; Biomedical engineering; Biomaterial; Treatment</ED>
<EG>Bone; Osteoarticular system</EG>
<GD>Korrosion; Nichtrostender Stahl; Aufbereiten</GD>
<SD>Corrosión; Cirugía; Acero inoxidable; In vitro; Ión metálico; Osteoclasto; Bisfosfonatos; Ingeniería biomédica; Biomaterial; Tratamiento</SD>
<LO>INIST-13764A.354000500656490090</LO>
<ID>13-0158452</ID>
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Pharmacological blocking of the osteoclastic biocorrosion of surgical stainless steel in vitro

Pharmacological blocking of the osteoclastic biocorrosion of surgical stainless steel in vitro

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